Medicine Drotaverine - how to take it correctly, dosage

general description

Drotaverine is an effective antispasmodic that helps relieve spasms of various etiologies.
Prescribed to reduce pain in diseases of the biliary and urinary tract. The drug quickly reduces pain caused by smooth muscle spasms in cholecystitis, cholangitis, cystitis, urethritis and many other diseases. The drug is successfully used in pediatrics. Allowed for children over 3 years old. In obstetrics and gynecology, Drotaverine is prescribed to relieve the symptoms of dysmenorrhea (painful periods), reduce the tone of the uterus during pregnancy, and also to stop contractions during early labor.

The drug also helps to reduce the severity of headaches of spastic origin, to alleviate the patient’s condition with colic, biliary dyskinesia, and peptic ulcers of the stomach and intestines.

When prescribing Drotaverine together with other medications, caution must be exercised. The medication enhances the effect of antispasmodics of other groups

There was a sharp decrease in blood pressure when drotaverine was used together with antidepressants.

Drotaverine

Compound

The composition includes the active ingredient drotaverine hydrochloride.

1 tablet contains 40 or 80 mg of this substance. Additional elements: talc, potato starch, povidone, magnesium stearate, lactose monohydrate.

1 ml of injection solution contains 20 or 40 mg of active substance.

1 ml of solution for IV and IM contains 20 or 40 mg of active substance, as well as additional elements: injection water, sodium disulfite and ethanol.

Release form

Available in the form of tablets, solution for injection, as well as in ampoules for intravenous and intramuscular administration.

pharmachologic effect

What is Drotaverine? This is a myotropic antispasmodic. Has a vasodilating effect.

Pharmacodynamics and pharmacokinetics

Compared to papaverine, it has a longer and more pronounced effect, despite the similarity in pharmacological properties and chemical structure. The mechanism of action is aimed at reducing the flow of calcium into smooth muscle tissue. Drotaverine hydrochloride dilates blood vessels, reduces intestinal motility, and the tone of smooth muscle tissue of internal organs. The drug does not affect the functioning of the autonomic nervous system and does not pass through the blood-brain barrier. The drug is prescribed when it is impossible to use m-anticholinergic drugs. When administered intravenously, the effect develops after 4 minutes, the maximum is recorded after half an hour. It is excreted to a greater extent by the kidneys and to a lesser extent by bile.

Indications for use of Drotaverine

Drotaverine solution and tablets - what are they for? The drug is prescribed for the prevention and treatment of biliary dyskinesia, biliary colic, spasm of smooth muscle tissue, gallbladder dyskinesia, cholecystitis, pyelitis, postcholecystectomy syndrome, intestinal colic, pilospasm, proctitis, spastic colitis, spastic constipation, gastroduodenitis. Often used during menstruation.

What else does the medicine Drotaverine help with? Indications for use of the drug are also: vasospasm, endarteritis, postpartum contractions, prolonged opening of the pharynx, spasm of the pharynx during delivery, threatened miscarriage, algodismenorrhea, cholecystography.

Contraindications

Drotaverine is not prescribed for atrioventricular block, arterial hypertension, cardiogenic shock, failure of the renal and hepatic systems. During pregnancy, angle-closure glaucoma, total atherosclerosis, breastfeeding, prostatic hyperplasia, it is prescribed after consultation with specialists.

Side effects

Drotaverine can cause a feeling of heat, palpitations, dizziness, a drop in blood pressure, increased sweating, and allergic reactions. When administered intravenously, arrhythmia, atrioventricular block, collapse, and respiratory depression may develop.

Instructions for use of Drotaverine (Method and dosage)

Drotaverine tablets, instructions for use

The medicine is prescribed to adults three times a day orally, 40-80 mg. No more than 240 mg.

Drotaverine injections, instructions for use

40-80 mg is administered subcutaneously and intravenously 1-3 times a day. In order to relieve renal and hepatic colic, 40-80 mg is administered intravenously slowly. Intra-arterial administration is acceptable for peripheral vascular spasm.

For children

Children from 3 years to six years of age can be administered 10-20 mg at a time, no more than 120 mg per day. 2-3 doses per day are acceptable.

Overdose

An overdose is manifested by impaired atrioventricular conduction, paralysis of the respiratory center, cardiac arrest, and decreased excitability of the heart muscle.

Interaction

The drug can weaken the effect of antiparkinsonian drugs (for example, levodopa). The drug enhances the effectiveness of antispasmodics, bendazole, papaverine. When taking procainamide, tricyclic antidepressants, and quinidine simultaneously, a drop in blood pressure is recorded. Reduces the spasmogenic effect of morphine. Phenobarbital enhances the effect of the medication.

Terms of sale

No recipe needed.

Storage conditions

In a dark, dry place, out of reach of children, at a temperature of no more than 25 degrees Celsius.

Best before date

No more than 3 years.

special instructions

Drotaverine is combined with antiulcer drugs in the treatment of peptic ulcer of the digestive tract. Therapy involves avoiding complex activities and driving.

OKPD code 24.42.13.727

Recipe in Latin:

Rp.: Tab. Drotaverini 0.04 D. td N 20 in tabul. S.

Drotaverine during pregnancy

The drug is contraindicated during this period of life. However, doctors still prescribe medication when the potential benefits of using the drug are higher than the possible risk to the unborn baby.

What is Drotaverine used during pregnancy? The product is used to get rid of muscle spasms of internal organs, that is, for example, to relieve uterine tone. It should be remembered that these situations are exceptional, and you should not take this medicine uncontrollably.

Analogs

Analogs of the drug are Dolce, Drotaverine Hydrochloride, No-Shpa, Spazoverine.

What is better Drotaverine or No-shpa?

The drugs are generally similar, since they have a similar effect and the same active substance. So Drotaverine is No-shpa, essentially the same. However, No-shpa is a more expensive product, since it is of imported origin.

When choosing No-shpa or Drotaverine, you should also remember that the latter is not a patented medicine.

Reviews of Drotaverine

An excellent and effective substitute for No-shpa, an inexpensive medicine with a good analgesic effect.

Among the disadvantages, they note: the product does not always help, it tastes bitter, sometimes it can make the tongue go numb, and there are also contraindications.

Drotaverine price, where to buy

The price of Drotaverine in 40 mg tablets is 20 rubles per pack of 20 pieces.

Drotaverine Forte 80 mg costs 50 rubles per pack of 20 pieces.

10 ampoules of 2 ml each cost 60 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

WER.RU

• Drotaverine hydrochloride tablets 40 mg 100 pcs. Pharmproekt JSC
• Drotaverine tablets 40 mg 20 pcs. Irbit Chemical and Pharmaceutical Plant
• Drotaverine tablets 40 mg 20 pcs. Ozon LLC
• Drotaverine tablets 40 mg 20 pcs.
• Drotaverine tablets 40 mg 20 pcs.

ZdravZone

• Drotaverine forte 80 mg No. 20 tablets Moskhimfarmpreparaty named after N.A. Semashko OJSC
• Drotaverine 2% solution for injection 2ml No. 10 ampoules Vifitech JSC
• Drotaverine ms 40 mg No. 10 tablets
• Drotaverine 40 mg No. 100 tablets /Alsi Pharma/Alsi Pharma CJSC
• Drotaverine ubf 40 mg No. 10 tablets

Pharmacy IFC

• Drotaverine g/chloronovleniye ZAO PFK, Russia
• Drotaverine g/chl-TevaTeva FP/Adifarm EAD, Bulgaria

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Pharmacy24

• Drotaverine forte tab. 80mg No. 20OZ GNTsLS (Ukraine, Kharkov)
• DrotaverinKievmedpreparat (Ukraine, Kyiv)
• Drotaverine solution for injection 2% ampoule 2ml No. 5 Darnitsa (Ukraine, Kyiv)
• Drotaverine tablets 0.04g No. 10 Red Star (Ukraine, Kharkov)
• Drotaverine tablets 0.04g No. 20 Red Star (Ukraine, Kharkov)

PaniPharmacy

• Drotaverine solution d/in. 2% amp. 2ml No. 5OZ GNTsLS
• Drotaverine solution d/in. 2% amp. 2ml No. 5OZ GNTsLS
• Drotaverine solution d/in. 2% amp. 2ml No. 5OZ GNTsLS
• Drotaverine solution d/in. 2% amp. 2ml No. 5OZ GNTsLS
• Drotaverine solution d/in. 2% amp. 2ml No. 5OZ GNTsLS

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BIOSPHERE

• Drotaverine 40 mg No. 20 tablet Khimpharm (Kazakhstan)
• Drotaverine hydrochloride 40 mg No. 10 tablet. Borisov ZMP (Belarus)
• Drotaverine hydrochloride 40 mg No. 20 tablet. Irbit chemical plant (Russia)

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PAY ATTENTION! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Drotaverine, be sure to consult with your doctor.

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Drotaverine analogues

For various reasons, not every patient can try it on themselves and find out how Drotaverine works. For some, the remedy is contraindicated; for others, due to frequent use, it has become rather weak and no longer works properly. Such people have to look for alternative options. It’s good that Drotaverine has enough substitutes, and most of them work just as effectively. Among the most famous and effective analogues, a separate list includes the following:

• Spakovin;
• Spasmol;
• Biospa;
• No-Shpa;
• Spasmonet;
• No-H-Sha;
• Nispasm;
• Nispasm forte;
• Nokhshaverin;
• Dolce;
• Ple-spa;
• Spazoverine;
• Papaverine;
• Papaverine-Health.

One of the most famous analogues of Drotaverine is No-Shpa. These drugs are often even confused, considered to be the same drug, but in reality they are two different drugs. Which, it’s true, have a lot in common. The same properties include the following:

• one active ingredient;
• one dosage per tablet;
• the same dosage regimen;
• similar side effects;
• contraindications;
• form of production.

To say, Drotaverine or No-Shpa, which is better, will only be possible by testing the medications on yourself and evaluating the main differences

Among the latter, it is worth focusing on the following:

• number of pills in the pack;
• release options (Drotaverine has many of them);
• crospovidone in Drotaverine;
• price – No-Shpa is much more expensive, which is why it is not suitable for all patients.

Composition and release form

Drotaverine is available in two forms:

1. ampoules (injection solutions);
2. pills.

The active ingredient is drotaverine hydrochloride. Each of the forms is absolutely identical in the amount of active ingredient - 40 mg contains one tablet and ampoule.

Drotaverine is produced by many pharmaceutical companies, the purpose and use of which do not affect the quality of the drug itself, they simply indicate a difference in the company of release.

That’s why Drotaverine has many names:

• Drotaverine - Teva;
• Drotaverine - Ellara;
• Drotaverine – Forte;
• Drotaverine – FPO;
• Drotaverine;
• Vero - Drotaverine.

Photo:

When buying Drotaverine from Darnitsa or any other, you should not worry about the quality of the product, since in all companies it is selected and has the same qualities, so domestic or even foreign packaging will contain the same drug, which does not differ from each other.

Drotaverine during pregnancy

In some cases, the drug is used during pregnancy.
Drotaverine can be used in doses prescribed by a doctor; independent use can lead to the development of negative consequences. What does the drug help with during pregnancy? The woman's position does not affect the main indications of the medication. It is used to eliminate spasmodic pain.

During pregnancy, the product can be used to relieve uterine tone.

This allows you to avoid premature birth and prevent the threat of miscarriage. The permissible dose is 40-80 mg. The optimal dosage is prescribed by the doctor after examining the patient.

In many countries, Drotaverine, Duphaston and Curantil are not used during pregnancy. The effect of these drugs on child development has not been fully studied. Therefore, it is not recommended to risk the health of the unborn baby.

Modern medicine is increasingly resorting to the help of this drug. It treats many spasmodic pains and provides relief from colic. The product is truly effective and, when used correctly, cannot harm human health.

Drotaverine, like other drugs, has side effects. However, using it in the prescribed dose will avoid negative reactions from the body. Therefore, expectant mothers need to carefully monitor the dosage of the medication.

Instructions

The product is intended to eliminate pathological conditions caused by spastic contraction of tissues. This is a myotropic drug. It is characterized by a large number of properties: analgesic, hypotensive, etc. The capabilities of the drug are due to its ability to affect the tone of soft tissues and blood vessels. Thanks to the relaxing effect, the general condition of the body is normalized

Caution should be exercised during therapy, because

uncontrolled use of drugs in this group can lead to significant effects on the respiratory system.

What do Drotaverine tablets help with?

Drotaverine, what does this synthetic drug help with? The main purpose of the drug is to relieve pain due to spasms in the internal organs. It effectively reduces smooth muscle tone, thus relieving pain.

Composition and release form

The drug is produced in the form of tablets “Drotaverine”, which helps many patients. The medicine is also used in the form of a solution for intramuscular intravenous injection. The active ingredient is drotaverine hydrochloride. Auxiliary elements of the tablets are lactose monohydrate, magnesium stearate, povidone, starch, sodium disulfite, water and ethanol.

Pharmacological properties

"Drotaverine" - what do these tablets help with? Medicine thanks to the action of the active component:

• reduces the tone of the gastrointestinal tract;
• dilates blood vessels;
• reduces the tone of the biliary and genitourinary systems;
• reduces intestinal motility;
• has an antispasmodic effect;
• has analgesic properties.

The medication increases the flow of oxygen to cells. The active substance is evenly distributed in the organs, creating a vasodilating effect. Compared to Papaverine, which has a similar formula, the medicine is more effective and lasts longer. The maximum concentration in the body when using tablets is observed after an hour.

Medicine "Drotaverine": what helps

The drug is prescribed if the patient feels pain with:

• stomach and intestinal ulcers;
• gastroduodenitis;
• proctitis;
• biliary and intestinal colic;
• cholecystitis;
• pylorospasm;
• pyelite;
• spastic constipation;
• postcholecystectomy syndrome;
• tenesmus;
• renal colitis;
• gallbladder disorders.

The medication is often used in combination with other drugs to treat spasms of the stomach and intestines. “Drotaverine” gives a good result, which is why these tablets are popular among women, for pain during menstruation, for contractions after childbirth, to prevent miscarriage and premature birth of a child. Instructions for use of "Drotaverine" indicate the possibility of its use for headaches resulting from vascular spasms.

The drug "Drotaverin": instructions for use

The tablets are taken orally with water, regardless of diet. They should not be crushed or chewed. The duration of therapy is determined by a specialist individually for each person. The volume of medication is calculated depending on the age of the patients, while the maximum daily dosage should not exceed 240 mg:

1. Children 2-6 years old are given 15-20 mg up to 2 times a day.
2. Up to 12 years – 20 mg twice.
3. Adults and adolescents over 12 years of age are prescribed 40-80 mg up to three times a day.

How to use "Drotaverine" in solution

When administered intramuscularly, adults are prescribed 2 to 4 ml three times a day. For colic and spasms of the liver or kidneys, intravenous use of the solution is recommended, which must be administered slowly. In exceptional cases, in case of circulatory problems, the medicine is injected into the artery.

For women during childbirth, the solution is injected into the muscle in a volume of 2 ml. If necessary, repeat the procedure after two hours. For intestinal and stomach ulcers, the drug is used in conjunction with antiulcer medications.

Contraindications

Do not use the medicine if:

• kidney and liver dysfunction;
• cardiogenic shock;
• arterial hypertension;
• atrioventricular block.
• Treat with caution when:
• prostate hyperplasia;
• angle-closure glaucoma;
• atherosclerosis;
• pregnancy;
• lactation.

Side effect

In general, the medicine is well tolerated by patients. Negative reactions of the body to the action of the drug "Drotaverine" are observed in rare cases, with an overdose and individual failure to take the constituent components. Side effects include:

• allergic dermatitis;
• bronchospasm;
• fainting;
• increased sweating;
• I am rejected in the sleep-wake mode;
• skin rash;
• decrease in pressure;
• vomiting and nausea;
• arrhythmia;
• headache;
• tachycardia.

When using the solution, blood pressure may decrease and respiratory depression may occur. The medicine reduces the effectiveness of Morphine and increases the effect of antispasmodics. In combination with Phenobarbital, the antispasmodic properties of the drug Drotaverine are enhanced.

Price and analogues

Medicines “No-shpa”, “Dolce”, “Spazoverin” have a similar effect. You can buy Drotaverine tablets for 25-30 rubles per pack of 20 pieces of 40 mg each. The solution costs 60-80 rubles for 10 injections of 2 ml.

Reviews

Patients say that Drotaverine is no worse in action than No-shpa. At the same time, the price of the drug is significantly lower. A good analgesic result is noted after taking the tablets. Some patients say that after using the drug the pain did not go away. The bitter taste of the tablets, the presence of contraindications and numbness of the tongue are also noted.

otchegopomogaet.ru

pharmachologic effect

The drug is a myotropic antispasmodic. This means that the principle of its action is based on changing the ionic balance in cell membranes. The advantage of this drug is the absence of a negative effect on the autonomic nervous system and central nervous system. As a result, there is a suppression of the contractile function of cells, relaxation of the smooth muscles of internal organs and soft tissues. Due to this, a decrease in the intensity of a number of negative manifestations is achieved: pain, hypertension, etc.

The drug in question represents a group of non-selective antispasmodics. The main function of the drug is realized by inhibiting phosphodiesterase. At the same time, accumulation of cyclic adenosine monophosphate is noted. The result of these processes is a decrease in the rate of entry of ionized calcium into the cells of soft tissues and smooth muscles.

In this case, other pathological conditions should be taken into account, in which a significant decrease in vascular and soft tissue tone is fraught with complications. The level of the drug is determined by the concentration of PDE4 (this indicator varies in different tissues)

There is a relaxing effect of Drotaverine on the gastrointestinal tract, genitourinary system and biliary tract. Considering the selective effect of the substance on various types of PDE isoenzymes, it becomes clear why complications from the central nervous system and cardiovascular systems do not occur during therapy

The level of the drug is determined by the concentration of PDE4 (this indicator varies in different tissues). There is a relaxing effect of Drotaverine on the gastrointestinal tract, genitourinary system and biliary tract. Considering the selective effect of the substance on various types of PDE isoenzymes, it becomes clear why complications from the central nervous system and cardiovascular systems do not occur during therapy.

This is due to the fact that hydrolysis in the smooth muscles of the walls of blood vessels and the myocardium is carried out through PDE3. The drug has no effect on this isoenzyme.

Pharmacokinetics

The advantage of the antispasmodic is its immediate absorption. In this case, a significant dose of the active substance enters the blood - 65%.

The highest level of effectiveness is achieved within the first 40-60 minutes after taking the medicine. The drug has a high ability to bind to plasma proteins - up to 98%. Thanks to rapid absorption, the active component spreads throughout the body in a short period.

The process of transformation of the active substance occurs in the liver. The kidneys are responsible for its excretion, but some of it is removed through the intestines.

Moreover, the active component is not found unchanged, since it is completely metabolized.

Interaction with medications

What is Drotaverine? This is a myotropic antispasmodic. Has a vasodilating effect.

Drotaverine can cause a feeling of heat, palpitations, dizziness, a drop in blood pressure, increased sweating, and allergic reactions. When administered intravenously, arrhythmia, atrioventricular block, collapse, and respiratory depression may develop.

The drug can weaken the effect of antiparkinsonian drugs (for example, levodopa). The drug enhances the effectiveness of antispasmodics, bendazole, papaverine. When taking procainamide, tricyclic antidepressants, and quinidine simultaneously, a drop in blood pressure is recorded. Reduces the spasmogenic effect of morphine. Phenobarbital enhances the effect of the medication.

When using a myotropic antispasmodic, it is advisable to avoid taking other painkillers, in particular m-anticholinergics. The tablets also reduce the effectiveness of levodopa and morphine. The combination of Drotaverine hydrochloride with quinidine and tricyclic antidepressants leads to an enhanced antihypertensive effect.

When undergoing therapy with Drotaverine hydrochloride, approximately 3-4% of patients experience side effects in the form of stool disturbances, nausea, bronchospasms, allergic dermatitis, arterial hypotension and tachycardia. It is recommended to stop using painkillers if the above symptoms are detected.

Drug interactions and special instructions

When including Drotaverine in a complex treatment regimen, care must be taken, since the active component sometimes interacts with the active ingredients of other drugs:

1. The drug reduces the antiparkinsonian effect of levodopa.
2. Drotaverine can enhance the effect of taking bendazole, papaverine and other antispasmodics, including those belonging to the group of anticholinergics. A sharp drop in blood pressure is possible when taking the drug together with antidepressants, procainamide.
3. Drotaverine reduces the antispasmodic effect of morphine.
4. When taken simultaneously, phenobarbital increases the effect of drotaverine hydrochloride.

Caution is exercised when using the described drug for the treatment of hypotensive patients, patients with atherosclerosis of the heart vessels. If excessive sensitivity to sodium pyrosulfite is detected, drip administration of the drug should be avoided, since this treatment regimen easily leads to severe allergic reactions.

When treating ulcers in the digestive system, drotaverine is prescribed together with antiulcer drugs (De-Nol, Omeprazole). Since the tablets contain lactose, the drug is not recommended for patients with lactase deficiency or diagnosed problems with the absorption of galactose or glucose.

Release form

The drug is produced in the form of tablets, film-coated tablets and solution for injection.

Drotaverine tablets are round, beveled and scored, yellow-green in color. Each tablet contains 40 mg of active ingredient. Excipients: povidone (polyvinylpyrrolidone), potato starch, milk sugar, talc and magnesium stearate. 10 pieces in a blister, 1, 2, 3, 4 and 5 blisters in a cardboard box or 100 pieces in a polymer jar and cardboard box.

Drotaverine Forte tablets contain 80 mg of active ingredient. 10 pieces in a blister, 2 blisters in a cardboard box.

Injection. 1 ml of solution contains 20 mg of drotaverine hydrochloride. In ampoules of 2 ml, 5 ampoules in blister packs, 2 packs in a cardboard box.

Composition, release format, main action

The active component of the drug is drotaverine hydrochloride. The product is produced in three medicinal versions: tablets, coated dragees (Drotaverine Forte), injection solution:

1. Pills

   . They have a round shape, a dividing chamfer in the middle and a yellowish-green tint. In addition to the active ingredient - drotaverine hydrochloride 40 mg - the drug contains potato starch, talc, magnesium stearate, milk sugar, and povidone.

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2. Dragee

   . This drug contains 80 mg of the active ingredient.

3. Injection
   . The drug is produced in dark glass ampoules of 2 ml, packaged in plastic cells of 5 pcs. Two cells are placed in a box with instructions. 1 ml contains 20 mg of drotaverine.

The medicine in the form of injections and droppers is prescribed only for acute spastic pain. It is desirable that treatment in this case takes place in a hospital setting.

The action of drotaverine hydrochloride is aimed at reducing the tone of the renal and digestive systems. It helps dilate blood vessels, reduces intestinal motility, and has antispasmodic and analgesic properties. In addition, the medication improves the flow of oxygen to cells and has a vasodilating effect.

The highest concentration of the active component in the blood is recorded one hour after administration. The medication disperses evenly in the tissues of the organs. The main part is excreted by the renal system, the smaller part is excreted with bile.

Release form and composition

The basic element of the drug is Drotaverine hydrochloride.
This is an antispasmodic substance with a myotropic effect. In addition to reducing irritation of the smooth muscles of the biliary and genitourinary systems, as well as the gastrointestinal tract, Drotaverine hydrochloride promotes the flow of oxygen to the organs.

The therapeutic effect of Drotaverine and the chemical composition are similar to Papaverine, but in terms of duration of action it differs for the better. The drug is considered a synonym (absolute analogue) of the well-known drug No-shpa.

Drotaverine hydrochloride is produced in the form of round tablets with a chamfer and a score, yellow-green in color, containing 40 or 80 mg of the active substance. The secondary components included in the composition are:

• Talc.
• Povidone.
• Magnesium stearate.
• Lactose monohydrate.

Another form of the medicine is a solution for intravenous and intramuscular injections, in which the volume of Drotaverine hydrochloride is 20 or 40 mg.

Structurally, the elements of the drug include:

• Sodium disulfite.
• Ethanol.
• Injection water.

Drotaverine solution and tablets do not harm the autonomic nervous system, do not provoke a sedative effect, and do not penetrate the blood-brain barrier. Usually prescribed when it is impossible to use m-choline blockers.

The drug, administered intravenously, begins to act after 4 minutes, and reaches its maximum after half an hour. It is excreted from the body mainly by the kidneys, as well as with bile.

With kidney or liver failure

For patients with renal or liver failure, exceptions are made when using Drotaverine - with such severe pain syndromes, the drug can be administered intravenously (in small doses). However, the specialist should be very careful and monitor the patient’s condition, since there is a certain risk of collapse (decreased blood supply to tissues, as a result of which the functions of some systems and organs are disrupted). Therefore, such medical procedures should be carried out by the patient exclusively in a supine position.

Therapeutic properties

The analgesic drug has antispasmodic activity against the smooth muscle layer of blood and lymphatic vessels, as well as smooth muscles of the urogenital, digestive and biliary systems. The active components of the tablets stimulate muscle relaxation and dilation of blood vessels, thereby eliminating spastic pain and improving tissue trophism.

The principle of operation of Drotaverine hydrochloride is associated with the ability to reduce the permeability of cell membranes and change their potential. Metabolites of the drug inhibit the activity of phosphodiesterase, thereby increasing the concentration of cAMP and the rate of absorption of calcium ions by cellular structures.

A myotropic analgesic is characterized by a relatively low degree of binding to blood proteins. When taking tablets orally, the maximum serum concentration of the active substances is achieved within 50-55 minutes. The breakdown of medicinal components occurs in the liver. Their half-life from the body averages 21-22 hours.

Side effects

Drotaverine is usually well tolerated. In rare cases, some side effects may develop:

• Vomiting or nausea;
• Fainting, disturbance of sleep and wakefulness, development of excessive sweating, headache;
• Arrhythmia, tachycardia, decreased blood pressure or feeling hot;
• Bronchospasm and slight swelling of the nasal mucosa;
• Itching, angioedema, skin rash, allergic dermatitis.

With intravenous administration of Drotaverine, a decrease in blood pressure and respiratory depression is sometimes observed.

Drotaverine enhances the effect of bendazole, papaverine and other antispasmodics, and also reduces the spasmogenic activity of morphine. When used simultaneously with levodopa, it weakens the effect of the latter. In combination with phenobarbital, the antispasmodic effect of Drotaverine increases.

There is no data on drug overdose.

Some facts

Drotaverine hydrochloride is an analgesic drug that has antispasmodic, myotropic, vasodilating and antihypertensive effects.
Produced by the pharmaceutical plant Pharmproekt, which was founded in 2001 in St. Petersburg. The analgesic contains drotaverine, which was first synthesized in 1961 by specialists from the Hungarian pharmaceutical company Quinoin. In terms of its chemical structure and therapeutic properties, it is not much different from papaverine, but has a more pronounced antispasmodic effect.

special instructions

The drug in question is used with caution when relieving symptoms of exacerbation of hypertension. In this case, it is necessary to constantly monitor the patient’s condition

In this case, it is necessary to constantly monitor the patient’s condition.

The intravenous method of drug delivery is recommended less frequently than the intramuscular or subcutaneous route. It also requires monitoring the patient's condition.

During pregnancy and breastfeeding

During the period of bearing a child (early and late), it is permissible to use the drug in question, but only for health reasons, taking into account the effect of Drotaverine on the fetus.

This antispasmodic is used with caution during breastfeeding

In childhood

The drug in tablet form is prohibited for use in the treatment of children under 3 years of age. Drotaverine injections are not given to patients under 12 years of age.

Effect on concentration

If tablets are used, it is permissible to drive a car and engage in other activities that require increased alertness.

When using the solution, you should avoid driving, since in this case the active substance is delivered directly to the blood and soft tissues, which can speed up the effect of the medicine.

Use during pregnancy and lactation

Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe medication if the hypothetical benefit for the pregnant woman is higher than the potential threat to the child.

During breastfeeding, you should avoid taking Drotaverine, since it passes into mother's milk and, accordingly, is passed on to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.

Often, medicine can be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.

Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be under the constant supervision of the attending physician.

Indications for use

The scope of use of drotaverine for the treatment of pathologies is quite wide. It is prescribed for the elimination and prevention of pain syndromes caused by spasms of the smooth muscles of internal organs or blood vessels. Therefore, if Drotaverine is recommended to patients, why these tablets are used and how to take them, you need to know:

1. Biliary tract: cholangitis, gallstone surgery, cholecystitis, colic in the liver, dyskinesia.
2. Spasms of the digestive system: dysfunction of the pylorus, stomach and intestinal ulcers, proctitis, gastritis.
3. Spasms of the urinary organs: renal colic, pyelonephritis, cystitis.
4. Vasospasm: arteritis, narrowing of veins, cerebral arteries, pain syndrome of tension.
5. Dysmenorrhea, threat of early labor, incessant contractions at the end of labor.

Drotaverine is also prescribed before performing any medical research in which it is necessary to insert an instrument into the body. It can be used before cholecystography, gastroscopy, and some other manipulations.

Analogues of Drotaverine

Drotaverine is one of the most inexpensive medicines of its medicinal group (from ten rubles and more). However, if its use is impossible or difficult, the doctor may prescribe similar drugs. Among the most commonly used:

1. No-Shpa. The cost of the medication, produced in the form of injections for administration, starts from fifty rubles in Russian pharmacies. The active substance of the solution is drotaverine hydrochloride. The main purpose is to relieve smooth muscle tone, eliminate spasms and pain.
2. Papaverine. The average cost of the drug is twenty to thirty rubles. The main active component of the solution is papaverine hydrochloride. The medication relieves muscle excitation, eliminates spasms of smooth structures and reduces pain.
3. Spasmol. The cost of the product is from thirty rubles in pharmacies. The main substance of the composition is drotaverine hydrochloride. A high concentration solution has a similar effect to Drotaverine and can be used as an alternative in the absence of contraindications.

Pharmacological group

Drotaverine is a drug with an antispasmodic effect. Pharmacological group – myotropic antispasmodic. In terms of chemical structure and therapeutic properties, it is close to hydrochloride, while surpassing the drug in terms of duration and effectiveness of the pharmacological effect.

Pharmacodynamics

Drotaverine hydrochloride relaxes smooth muscle in internal organs, reduces the mobility of muscle fibers, slightly dilates small blood vessels and restores microcirculation in tissues. The antispasmodic myotropic effect occurs due to a slowdown in the flow of calcium into cells as a result of inhibition of the synthesis of the phosphodiesterase enzyme and the accumulation of cAMP in the cytoplasm of cells.

Pharmacokinetics

The drug is completely absorbed in the digestive tract. Peak concentrations in the blood occur 2 hours after taking the tablets orally. In peripheral blood, it is 98% bound to transport proteins. Accumulates mainly in the smooth muscle muscles of internal organs. Drotaverine does not penetrate the blood-brain barrier (BBB) ​​and the hematoplacental barrier. Does not affect brain function or intrauterine development of the fetus. Metabolized in the liver. It is excreted from the body mainly through urine; a small amount of the drug is contained in bile and excreted in feces.

Drotaverine: composition and pharmacological action

The drug is available in two dosage forms - a solution for intramuscular injection and tablets. The first includes:

• main component – ​​drotaverine hydrochloride;
• additional substances.

Tablets contain:

• drotaverine hydrochloride;
• lactose;
• additional components.

The drug is prescribed in tablet form more often than in injections.

After taking the drug, the active substance, which has antispasmodic activity, begins to affect the smooth muscles that are located in the genitourinary, biliary, cardiovascular and gastrointestinal systems. It significantly dilates the blood vessels, as a result of which oxygen begins to flow freely to the tissues and relieves spastic pain.

The components of the drug are capable of changing the permeability and potential of membranes in the tissue in a short period of time. They also reduce the activity of phosphodiesterase, a special enzyme.

After taking the tablet, the concentration of the active substance will reach its concentration in 50-60 minutes. Excreted from the body in urine, a small amount may be excreted in feces.

At the same time, the drug Drotaverine does not have any serious side effects in relation to the cardiovascular system, comparing favorably in this regard with many of its analogues. It is a drug with antispasmodic, vasodilating, myotropic and hypotensive effects.

Features of application

The use of the drug for hypotension requires increased caution. Drotaverine tablets contain 53 mg of lactose. When taken according to the recommended dosage, each dose contains up to 159 mg of lactose.

It may cause gastrointestinal distress in individuals who are lactose intolerant. This dosage form is not suitable for patients suffering from lactose deficiency, galactosemia or glucose/galactose malabsorption syndrome

Drotaverine tablets contain 53 mg of lactose. When taken according to the recommended dosage, each dose contains up to 159 mg of lactose. It may cause gastrointestinal distress in individuals who are lactose intolerant. This dosage form is not suitable for patients suffering from lactose deficiency, galactosemia or impaired glucose/galactose absorption syndrome.

Pregnancy and lactation

The use of drotaverine during pregnancy does not lead to teratogenic and embryotoxic effects

However, caution is required when prescribing the drug during pregnancy.

Due to the lack of necessary clinical data, it is not recommended to prescribe during lactation.

Impact on the ability to drive vehicles and operate machinery

Patients should be informed that if dizziness occurs, they should avoid potentially dangerous activities, such as driving or operating potentially dangerous machinery.

The drug Drotaverine hydrochloride

has antispasmodic activity against the smooth muscles of the gastrointestinal tract, biliary and urogenital systems, as well as against the smooth muscle layer of blood vessels.
The drug helps relax smooth muscles, eliminates spastic pain, and by expanding the lumen of blood vessels, improves the supply of oxygen to tissues. The mechanism of action of the drug is associated with its ability to change the potential of cell membranes and their permeability. The drug reduces the activity of the phosphodiesterase enzyme, promotes a consistent increase in the level of cAMP and an increase in the initial absorption of calcium ions by cells. The drug is characterized by a low degree of binding to plasma proteins (binds mainly to albumin, alpha and beta globulins). After oral administration, the peak concentration of the active substance in the blood plasma is reached within 45-60 minutes. Metabolized in the liver. The half-life is approximately 22 hours. It is excreted mainly in the urine in the form of metabolites; a certain amount of the drug is excreted in the feces. Drotaverine
penetrates the hematoplacental barrier.

Form of production and composition

Drotaverine hydrochloride is available in the form of flat yellow round tablets, which include:

• drotaverine (40.0 mg);
• octadecanoic acid;
• milk sugar;
• food additive E1414;
• emulsifier T553b.

The tablets are packaged in blisters of 10 pieces or in plastic bottles of 100 pieces. The cardboard box contains 20, 50 or 100 tablets along with instructions for use of the myotropic antispasmodic.

What are the indications for taking Drotaverine?

What kind of drug is “Drotaverine”? What are these pills for? The drug is aimed at reducing the tone of the smooth muscles of many internal organs and weakening the peristalsis of the intestinal tract. It can dilate blood vessels. Often the medicine is prescribed to eliminate spasmodic syndrome. Although the medication is not a painkiller, it affects the cause of the pain.

Thus, the following diseases and conditions may be indications for the use of the drug “Drotaverine”:

1. Exacerbation of stomach and duodenal ulcers.
2. Pylorospasm.
3. Intestinal colic, proctitis.
4. Spastic colitis, constipation, tenesmus.
5. Pain due to spasms of the vessels of the head, coronary arteries, endarteritis.
6. Pyelitis.
7. Biliary dyskinesia.
8. Biliary and renal colic.
9. Cholecystitis.
10. Threat of miscarriage or onset of premature labor.
11. If the dilation of the uterus is delayed during childbirth, as well as during postpartum contractions.
12. The medicine is prescribed during preparation for various procedures, for example, when installing a catheter in the ureters, or during cholecystography.
13. As part of complex therapy for diseases of the gastrointestinal tract.
14. Menses with severe pain.

In addition, sometimes a spastic headache can be relieved with the help of Drotaverine.

If the tablet form is prohibited for some reason, then the medicine can be used in the form of a solution.

It is prescribed to eliminate spasms of smooth muscles:

1. In the urinary system. For example, with nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesmus.
2. For diseases of the biliary tract. These include cholecystolithiasis, cholangiolithiasis, pericholecystitis, cholangitis, papillitis.

Thus, we can conclude that the medicine can be used for symptomatic treatment, when the main symptom of the disease is pain, during certain medical manipulations and procedures, in gynecology, and even for preventive purposes when there is a threat of the development of certain diseases. The scope of the medicine is wide.

Instructions for using the medicine

The medication in tablets is taken orally after meals. The medicine must be swallowed whole, without biting or chewing. The dragee should be drunk with a little water. How much you need to take the drug is indicated in the instructions for Drotaverine.

Tablets are prescribed according to the patient's age. Dosages are the same for any disease:

• For adults: 1-2 tablets twice a day. The maximum daily dose is 240 mg.
• For children 3−6 years old: 1 tablet per day. You can take no more than 120 mg per day.
• For children 6−12 years old: 1−2 tablets daily. The maximum dosage per day is no more than 200 mg.

The course of therapy is usually 7−15 days. If the first course does not help, the doctor may extend treatment with Drotaverine.

The solution is administered to patients intravenously for hepatic and renal colic, intra-arterially for spasms of peripheral vessels, and for other pathologies - intramuscularly or subcutaneously.

Medicine dosage:

• For persons over 12 years of age: 1-2 ampoules (40-80 mg) 1-3 times a day. The maximum dose per day is 240 mg.
• For children 6−12 years old: 20 mg daily. Take no more than 200 mg per day.
• For children under 6 years old: 10-20 mg 1-3 times a day. The dosage does not exceed 120 mg per day.

Indications

"Drotaverine" is prescribed both in the presence of pain and functional disorders in the functioning of internal organs due to spasms of smooth muscles, and in order to prevent such problems.

The medicine is used:

• For abdominal pain caused by spastic constipation, gastritis, pylorospasm, intestinal colic, enteritis, flatulence and other gastrointestinal lesions.
• For hepatic colic, biliary dyskinesia, cholangitis and other diseases of the biliary tract.
• For cystitis, bladder spasms, pyelitis, renal colic and other pathologies of the urinary system.
• For headaches.
• With vasospasm (at high temperature).
• For examinations during which a medical instrument is inserted into the body (for example, during gastroscopy).
• For severe dry cough caused by bronchospasm or laryngotracheitis. Although this indication is not noted in the official instructions, many doctors treat the bronchi, so they recommend taking the drug at night so that the child does not suffer from coughing and sleeps peacefully.

The injection form of the drug is prescribed in exceptional cases and only in acute conditions, in order to help the child as quickly as possible. As soon as the spasm is relieved, they switch to the use of tablets. In addition, Drotaverine injections are prescribed if it is impossible to give pills to a small patient.

What is drotaverine from?

If you are wondering what drotaverine does, it means you are suffering from spasmodic pain. Trouble can be helped - but first consult a doctor.

Drotaverine is an antispasmodic drug, a cheaper analogue of the well-known no-shpa. It is available without a prescription, but is taken only as prescribed by a doctor: if you have a stomach, headache or liver pain, first of all, you need to determine the cause of the pain, and then go to the pharmacy. This article is not medical, but for informational purposes, and in no way can serve as a guide to action. From it you will learn what drotaverine is used for, how and for what diseases it is taken, as well as contraindications and side effects of this drug.

What are Drotaverine tablets for?

It’s worth knowing what drotaverine tablets are for: it’s good if this information is not useful to you - but those who are aware will be able to deal with the problem.

Like no-shpu, drotaverine is taken for various pains caused by spasms, and also as a vasodilator. Under the influence of the drug, the smooth muscles of the cavities of the internal organs - the liver, kidneys, gastrointestinal tract, cardiovascular system - relax, and you feel better. However, the activity of intestinal motility also decreases, which can cause constipation - therefore, while taking drotaverine, it is recommended to eat more food rich in fiber.

For patients suffering from diseases of the cardiovascular system, this drug is also recommended with caution. In case of severe heart failure, as a rule, it is not prescribed at all: when the “engine” is already working at half capacity, it is better not to relax it with antispasmodic drugs. Even a relatively healthy person from a drotaverine tablet can experience increased heart rate, dizziness and weakness - even if the chance of side effects is not too great, it must be taken into account.

Indications for use of Drotaverine

Indications for the use of drotaverine are all kinds of diseases characterized by the occurrence of painful spasms.

The main indications for the use of drotaverine are renal, biliary and intestinal colic, cholelithiasis and nephrolithiasis, as well as diseases of the urinary tract associated with the occurrence of spasms. This drug is also prescribed for diseases of the gastrointestinal tract - stomach and duodenal ulcers, spastic constipation, colitis and others, as an analgesic and antispasmodic agent. Taking drotaverine is advisable for headaches and angina caused by vascular spasms.

During pathological childbirth, when spasm of the uterine pharynx prevents its opening, the woman in labor is given drotaverine once. The reception can be repeated if postpartum contractions occur. This drug is also prescribed to pregnant women during conservation if there is a possibility of miscarriage or premature birth.

Instructions for use of Drotaverine

Below are instructions for using drotaverine for adults and children. Strictly adhere to the indicated dosage!

The daily dose of the drug for adults and children over 12 years of age is 120-240 mg (1-2 tablets 2-3 times a day). When treating children 6-11 years old, a single dosage of 40 mg 2-5 times a day should be followed. Children under 6 years old - 40 mg no more than three times a day. Drotaverine is not prescribed to children under one year of age.

Instructions for use of drotaverine: tablets are taken orally after meals with water. In case of emergency assistance, drotaverine solution is administered intravenously. In this case, the dose and frequency of injections is determined by the doctor.

Drotaverine during pregnancy

Like almost any medicine, drotaverine should be used during pregnancy only if absolutely necessary, or replaced with a safer analogue.

It is not recommended to take drotaverine during pregnancy. This drug is not prescribed to women in the first trimester, and in the last two - with great caution, on the recommendation of a doctor and under his supervision. During lactation, taking drotaverine is prohibited.

Analogues of Drotaverine

Not everyone knows this, but there are analogues of drotaverine with less intense action. This drug is also produced under other trade names.

As mentioned above, drotaverine is the same no-spa. The reason for the price difference between these two drugs is that everyone knows the name of the second one. Everyone knows that you need to drink no-shpa for cramps, and they buy it, while the cheaper drotaverine remains gathering dust on the shelves. In fact, they are absolutely similar, so there is no point in overpaying. Other trade names of drotaverine are bespa, bioshpa, spasmol, spasmonet, spasmoverine, spakovin.

There are other analogues of drotaverine. Papaverine, mebeverine, hyoscine butyl bromide, otilonium bromide have the same effect on the human body, but weaker. They are prescribed for mild pain - and if relief does not occur, these drugs are replaced with drotaverine.

Weaker analogues are also prescribed if the doctor is afraid of side effects in the patient - for example, with renal failure or severe allergic reactions to the components of the drug, the patient may not survive treatment with drotaverine.

In some cases, drotraverine is recommended to be replaced with other antispasmodics, such as papazole and its analogues. Only a doctor can choose the right drug that has a maximum therapeutic effect and a minimum destructive effect on the patient’s body. Therefore, it is worth repeating, do not self-medicate!

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Side effects

Side effects are recorded extremely rarely, but before taking the drug it is worth familiarizing yourself with them. In rare cases, the use of the drug may cause the following side effects:

• nausea,
• vomit,
• fainting,
• sleep disorders,
• development of headache
• increased sweating,
• arrhythmia,
• lowering blood pressure,
• tachycardia,
• feeling of heat.

Sometimes allergic reactions may occur, such as rash, dermatitis, swelling of the nasal mucosa and bronchospasm, and in extremely rare cases, angioedema may occur. Intravenous administration sometimes causes a decrease in blood pressure.

Pharmacodynamics and pharmacokinetics

Compared to papaverine, it has a longer and more pronounced effect, despite the similarity in pharmacological properties and chemical structure. The mechanism of action is aimed at reducing the flow of calcium into smooth muscle tissue. Drotaverine hydrochloride dilates blood vessels, reduces intestinal motility, and the tone of smooth muscle tissue of internal organs.

The drug does not affect the functioning of the autonomic nervous system and does not pass through the blood-brain barrier. The drug is prescribed when it is impossible to use m-anticholinergic drugs. When administered intravenously, the effect develops after 4 minutes, the maximum is recorded after half an hour. It is excreted to a greater extent by the kidneys and to a lesser extent by bile.

What does Drotaverine tablets help with?

What Drotaverine is, what these tablets are for - this issue needs to be carefully understood before stocking up on the medicine. The medication has an antispasmodic, vasodilator, myotropic, hypotensive effect. Regardless of what drug Drotaverine is taken, it reduces the amount of active ionized calcium, which enters smooth muscle cells and is quickly absorbed in the gastrointestinal tract.

The great advantage of the drug is that Drotaverine, no matter what you take these tablets for, does not affect the autonomic and central nervous systems. That is, taking the drug does not disrupt the normal rhythm of life and does not dull reactions. In this case, the pills begin to act within about 12 minutes, after they enter the body and dissolve there.

Drotaverine for pain

This is the first answer that comes to mind: Drotaverine - what are these tablets for? From pain. The miraculous antispasmodic mechanism is directly related to the ability of the drug to change the potentials of cell membranes and their permeability. The same effect can be achieved with spasms of different origins - both nervous and muscle. You can take Drotaverine for headaches of any nature and expect a positive result.

Drotaverine on temperature

For many, this drug is purely an anesthetic, but in fact, Drotaverine hydrochloride can also be used instead of an antipyretic. Moreover, the medicine works no worse than the main remedies for fever. The secret is that the medicine has a vasodilating effect. Thanks to this, the temperature quickly “leaves” from the body, evaporates, to put it simply.

Drotaverine for blood pressure

The vasodilating effect makes it possible to use the drug Drotaverine during pressure surges. When the vessels narrow, the tissues and organs that feed through them begin to starve - they do not receive as much oxygen as they need. Drotaverine helps restore normal blood circulation and thereby put the whole body in order.

Drotaverine for cough

This is one of the most unexpected, but no less effective uses of the product. When remembering the medicine Drotaverine, what these tablets help with, cough is the last thing that comes to mind, but the drug actually helps with this problem. When spasms are painful and interfere with sleep. To get rid of them, you need the drug Drotaverine in the amount of two pills and one tablet of Suprastin. This composition will clear up your cough in a matter of minutes and restore restful sleep.

Drotaverine for nausea

Some people who are keen on self-medication are sure that one of the problems for which Drotaverine is prescribed is nausea, and this issue needs to be clarified. The fact is that it is dangerous to take any painkillers and Drotaverine, including for nausea and other gastrointestinal disorders. The reason is that poisoning is always accompanied by excessive gas formation. Antispasmodics relax smooth muscles, thereby making it even more difficult for gases to escape. That is, they not only do not help, but even worsen the condition and well-being.

What does Drotaverine help with - diseases and symptoms

What does drotaverine, an effective and often prescribed drug with an antispasmodic effect, help with? It has a beneficial effect on smooth muscle tissue of various body systems, eliminating spasms and pain of both nervous and muscular etiology.

No serious side effects were noted, however, the drug should be prescribed exclusively by a doctor and taken by the patient under the supervision of a specialist.

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Drotaverine: composition and pharmacological action

The drug is available in two dosage forms - a solution for intramuscular injection and tablets. The first includes:

• main component – ​​drotaverine hydrochloride;
• additional substances.

Tablets contain:

• drotaverine hydrochloride;
• lactose;
• additional components.

The drug is prescribed in tablet form more often than in injections.

After taking the drug, the active substance, which has antispasmodic activity, begins to affect the smooth muscles that are located in the genitourinary, biliary, cardiovascular and gastrointestinal systems. It significantly dilates the blood vessels, as a result of which oxygen begins to flow freely to the tissues and relieves spastic pain.

The components of the drug are capable of changing the permeability and potential of membranes in the tissue in a short period of time. They also reduce the activity of phosphodiesterase, a special enzyme.

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After taking the tablet, the concentration of the active substance will reach its concentration in 50-60 minutes. Excreted from the body in urine, a small amount may be excreted in feces.

At the same time, the drug Drotaverine does not have any serious side effects in relation to the cardiovascular system, comparing favorably in this regard with many of its analogues. It is a drug with antispasmodic, vasodilating, myotropic and hypotensive effects.

Indications for use

Why Drotaverine can be prescribed by a therapist - the specialist must exclude individual intolerance to the components of the drug. The main indication for its use is to relieve a person of spastic pain that can occur with a variety of ailments. The drug may be prescribed if one of the following diseases has been diagnosed:

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• frequent spasms with cholecystitis;
• stomach or duodenal ulcer;
• constipation, accompanied by spasms of smooth tissues that cause severe pain;
• colic due to gas retention;
• urethritis and cystitis;
• proctitis with pronounced pain;
• urethrolithiasis, pyelitis, nephrolithiasis - for these diseases, Drotaverine is prescribed as a local anesthetic drug, and it is part of a complex of medications.

Along with this, a medicine such as Drotaverine can be recommended for use during diagnostic procedures. For example, with cholecystography or similar.

Elimination of spasms is the main task of Drotaverine

Because the drug has a vasodilating effect, health care providers often prescribe it to relieve severe headaches that occur when cerebral vasospasms occur.

The use of Drotaverine in gynecology is widespread - it can help with spasms of the uterine pharynx or with prolonged dilatation. It is also prescribed for emergency childbirth if the specialist notes the risk of uterine spasms during the passage of the fetus.

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Taking Drotaverine

The tablets are taken orally and should be taken with plenty of water. The frequency of meals, as a rule, does not have any effect, so there is not much difference in taking Drotaverine before or after meals. You can even do it on an empty stomach if a person suffers from severe pain or colic. The only inconvenience in this case is that the impact on the source of discomfort may begin a little later.

If the patient is suffering from too much pain that he cannot bear, the doctor may prescribe injections. They act much faster because they are administered intramuscularly. However, there are exceptions for patients with hepatic or renal colic - in them the drug is administered intravenously (slowly and in small portions). At the same time, there is a small risk of collapse (decreased blood supply to tissues, resulting in dysfunction of certain organs), so such procedures should be carried out exclusively in a supine state.

Important: it is prohibited to independently determine the duration of the course; only a specialist can choose how to take Drotaverine.

In particularly emergency cases, when vasospasm occurs and peripheral circulation is disrupted, Drotaverine can even be injected into an artery. The dosage must be carefully calculated by the doctor, and the drug should be administered even more slowly than intravenously.

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Important: since the procedure is emergency, it should only be performed by a specialist. He will also be able to stop possible consequences (although, as a rule, they do not arise with the competent actions of a medical professional).

Compatibility of the drug with other drugs

If you use Drotaverine for the abdomen or in other cases in combination with other drugs that also have an antispasmodic effect, the effect of treatment may be enhanced, but such therapy should be carried out exclusively with the approval of the attending physician. Only a specialist will recommend medications that not only will not cancel the therapeutic effect of Drotaverine, but will also be able to make it more pronounced.

If you combine Drotaverine with tricyclic antidepressants, you should be prepared for the fact that arterial hypotension may increase many times over.

Patients who have been prescribed morphine should use Drotaverine with caution, as this drug greatly reduces the spasmogenic effect.

Overdose of Drotaverine

It is strictly forbidden to change the dosage prescribed by your doctor. An increase in the number of tablets or injections can provoke the development of atrioventricular block and lead to paralysis of the respiratory nerve, and the consequences of this can be extremely negative.

Possible side effects

Side effects from taking Drotaverine can occur in two cases: if it is taken for too long or if an allergic reaction to any component occurs. Such actions include the following manifestations:

• gastrointestinal tract - belching, constipation (or vice versa diarrhea), feeling of nausea, vomiting;
• central nervous system – fainting, severe headaches, disrupted daily routine, sleep disturbances;
• respiratory tract – swelling of the mucous membranes or bronchospasms;
• allergic reactions - Quincke's edema, dermatitis, rash, excessive sweating, itching;

All the described effects occur both when taking tablets and after injections, however, in the latter case, the patient may begin to develop depressed breathing, hypotension, or atrioventricular block (impaired conduction of electrical impulses from the atria to the ventricles).

It is important to follow the dosage of the drug, otherwise side effects may occur.

If you have headaches while taking Drotaverine or one of these side effects has been noted, and especially after injections, then the course of treatment should be stopped and you should consult your doctor. He will be able to either select analogues or prescribe additional medications to eliminate these actions.

Use during pregnancy and lactation

Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe medication if the hypothetical benefit for the pregnant woman is higher than the potential threat to the child.

During breastfeeding, you should avoid taking Drotaverine, since it passes into mother's milk and, accordingly, is passed on to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.

Often, medicine can be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.

Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be under the constant supervision of the attending physician.

Contraindications for use

As a rule, almost all medicines have certain contraindications, and Drotaverine is no exception. It should be used only after reading the instructions and according to the prescribed course of treatment. Contraindications are identical regardless of which form of the drug was chosen. These include:

• heart failure;
• cardiogenic shock;
• low blood pressure;
• atrioventricular block II or III degree;
• renal or liver failure;
• congenital lactase deficiency;
• malabsorption.

Advice: it is not recommended to use Drotaverine tablets for children under 12 years of age - exclusively in the form of injections.

The drug is prescribed with caution to those diagnosed with atherosclerosis of the coronary arteries, the same applies to the usual form of atherosclerosis. It is not recommended for people whose professional activities require increased concentration. If, nevertheless, taking Drotaverine is necessary, then after it you should avoid activities that require increased attention and concentration for 2-3 hours.

All information in the article is for reference only, so if you do not know what Drotaverine is and how to take it, consult a specialist. Only a doctor can make a correct diagnosis and assess how necessary it is to take this drug.

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Instructions for use

Like the bulk of Drotaverine tablets, it should be taken orally. The product is placed in the mouth and washed down with a sufficient amount of clean liquid, without the need to crush, dissolve or chew it.

The duration of the therapeutic course, as well as the required daily dose, is determined by the leading specialist after collecting data and examining the patient.

1. If it is necessary to relieve a spasmodic attack in an adult or teenager, it is recommended to take no more than 2 tablets (40 mg) per day. A maximum of 240 mg of Drotaverine can be taken in 24 hours.
2. For the treatment of children under adolescence, the dosage is determined exclusively by the doctor.
3. At the age of 6 to 12 years, you can take no more than 40 mg of the drug per day.

Administration is performed intramuscularly; in exceptional cases, for example, if the patient has liver or kidney dysfunction, it can be administered intravenously (very slowly, drip). To prevent collapse, if administration is carried out intravenously, the patient should be in a horizontal position.

1. Adults are administered no more than 4 ml of Drotaverine 1 to 3 times a day.
2. For the treatment of adolescents, 2 ml or less can normally be administered 1 to 3 times a day.

As for the duration of taking the drug, this decision should be made only by the attending physician. Independently determining the duration of treatment can lead to unpleasant complications. Only a qualified specialist is able to adequately assess all possible risks.

Side effects

Some undesirable reactions cannot be ruled out due to the use of Drotaverine in tablets and injections. The instructions for use contain the following information. The most common side effects of the drug are:

• disruption of the digestive process, consisting of dyspepsia and changes in stool;
• fainting;
• cephalgia;
• swelling of the mucous membrane;
• bronchospasm;
• Quincke's edema;
• sleep disturbance;
• dermatitis;
• increased sweating;
• decreased pressure in the arteries;
• depressed respiratory function;
• atrioventricular block;
• bradycardia;
• violation of impulse patency from the atrium to the ventricles.

Overdose

When using excessive doses of the drug, patients experience the development of atrioventricular block, cardiac arrest and paralysis of the respiratory center.

There is no specific antidote. In case of overdose, discontinuation of the drug and symptomatic therapy are indicated.

For atrioventricular block, atropine and isoprenaline are used intravenously; in case of cardiac arrest, the use of atropine or adrenaline intravenously and temporary cardiac stimulation are indicated; in case of respiratory arrest due to paralysis of the respiratory center, artificial ventilation is indicated.

Treatment of drug overdose should be carried out under the constant supervision of medical personnel.

Drug interactions

1. When used in combination, the drug may reduce the effectiveness of levodopa.
2. With the simultaneous use of drotaverine with other drugs that have antispasmodic activity, there is a mutual enhancement of therapeutic effects.
3. When using the drug simultaneously with tricyclic antidepressants, procainamide and quinidine, an increase in arterial hypotension caused by these drugs is observed.
4. Drotaverine helps reduce the spasmogenic effect of morphine.
5. When used simultaneously, phenobarbital enhances the antispasmodic effect of drotaverine.

Directions for use and dosage

Drotaverine tablets are taken orally; there is no need to crush or chew them. The moment of eating can be ignored.

The course lasts for the time prescribed by the doctor and depends on the individual characteristics of the patient. The dose is calculated taking into account age:

• children from 3 to 6 years old – 10-20 mg (a quarter or half a tablet) – 2-3 times a day. The maximum dose is 120 mg per day;
• from 6 to 12 years – 20-40 mg 2 to 5 times (half or whole tablet) per day. The usual dose used at this age is 200 mg (5 tablets);
• adolescents over 12 years old and adults – 40-80 mg (1-2 tablets) – 2-3 times a day. The optimal daily dose of 240 mg is not allowed to be exceeded.

The course for children and adults is the same and lasts about 1-2 weeks. If longer-term use is necessary, you should consult a specialist.

Liquid for injections is mainly administered intramuscularly. The time and dose are chosen personally.

Hepatic or renal colic is relieved by administering a solution through a dropper, intravenously. In advance, 2-4 ml of the product are diluted with 0.9 ml of sodium chloride solution.

If the patient's hemodynamics are impaired, Drotaverine injections are given into the artery. During physiological childbirth, mothers are shown Drotaverine, injections of which are given into the muscle when the cervix is ​​dilated. After 2 hours, the procedure can be repeated.

Taking into account the condition of adult patients and children over 12 years of age, the dosage of injections was also calculated. They are administered a solution in a volume of 40-80 mg (1-2 ampoules) 1-3 times a day.

The method of administration is chosen by the doctor. The maximum daily dosage cannot exceed 240 mg (equal to 6 ampoules).

Children, based on their age, are treated with Drotaverine hydrochloride, the instructions for which recommend administering the solution in the following dosage:

• from 1 to 6 years – 10-20 mg 1-3 times a day. It is allowed to administer no more than 3 ampoules (120 mg);
• from 6 to 12 days – 20 mg up to 3 times a day. Dose – 200 mg solution (5 ampoules).

When else is Drotaverine used, what does it cure? The medication is effective for treating ulcerative pathology of the stomach and duodenum, but therapy should be carried out in combination, with the involvement of other antiulcer drugs.

Although the medicine is not considered a painkiller, in many cases it, by eliminating the cause of pain, also reduces the pain itself.

Thus, the use of Drotaverine for headaches is guaranteed to alleviate the patient’s condition. The medicine is especially effective during headaches caused by stress, lack of sleep, and high blood pressure. In most cases, tablets are used.

In order to choose what to treat with, Papaverine or Drotaverine, you should keep in mind that the latter has a milder effect on blood pressure. In addition, using Drotaverine for headaches is also useful because it helps saturate the body with oxygen.

However, if side effects such as dizziness, sweating, and insomnia occur, the drug should be discontinued.

Additional Information. Drotaverine, whose indications extend to the treatment of headaches, relieves not only painful sensations, but also relieves vasospasm, eliminates ringing in the ears, and increases performance.

If you combine the drug with Analgin, you can get an effective antipyretic.

It is best to administer the drug intravenously in a supine position to avoid collapse. To dilute the ampoule, take a saline solution, approximately 10-20 mg, or a 5% glucose solution.

For subcutaneous and intramuscular injection, the medicine is not diluted.

Analogs

Instead of Drotaverine, you can use products with the same composition and substitutes that contain other active components, but are characterized by similar pharmacological effects. Common analogues:

1. No-shpa;
2. Papaverine;
3. direct substitutes for Drotaverine: Forte, Teva, Avexim.

The analogue of Drotaverine is the drug Papaverine.

The first option contains the component of the same name. The dosage in tablets is the same as that of the product in question. The ampoules contain a more concentrated solution - 40 mg of the drug in 2 ml of liquid preparation. For this reason, the dosage of No-shpa should be recalculated when prescribed in ampoules.

Papaverine contains the substance of the same name. Its amount in tablets and solution is the same as that of the drug in question: 40 and 20 mg, respectively.

The substance papaverine acts on a similar principle as Drotaverine. For this reason, the products that contain them are interchangeable.

Drotaverine Forte has a higher concentration of the main component and is 80 mg per tablet. The drug is prescribed when it is necessary to take increased doses of an antispasmodic. Drotaverin Teva and Avexim contain the same main active ingredient, and its dosage remains unchanged. These drugs are offered in tablet form.

Drotaverine belongs to the group of myotropic antispasmodics. In its structure and effect on smooth muscles, the drug is similar to papaverine, but has a more pronounced therapeutic effect.

Reduces the tone of smooth muscles of internal organs and intestinal motility, dilates blood vessels. Most often, the medication is prescribed for various spasmodic pains, although it is not an analgesic.

On this page you will find all the information about Drotaverine: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Drotaverine tablets. Would you like to leave your opinion? Please write in the comments.

Analogues of the drug

In some cases, the doctor may replace Drotaverine with another medicine. Analogs of medicines that have the same active substance: No-shpa, Droverin, Bioshpa, Spasmol.

According to the mechanism of action, substitutes are used in the form of Nikoverine, Papaverine, Papazole or Platiphylline. You cannot prescribe these medications yourself. Before use, be sure to consult a specialist.

Some people consider Drotaverine and No-shpu to be the same drug. Both medicines contain the same active ingredient, but there are differences between them. During the production of No-shpa, the active component is subjected to a high degree of purification from impurities. Thanks to this, the remedy is often more effective than Drotaverine. In addition, No-shpa rarely has negative consequences.

The active substance Drotaverine is purchased from chemical laboratories in India and China, and is not produced by the pharmaceutical factories themselves. Since its level of purification is lower than that of the main component of No-shpa, after using the drug, negative consequences appear more often.

Drotaverine contraindications for use

So far, pharmacists have not been able to make a drug that would suit everyone perfectly. And effective Drotaverine has certain contraindications. You should not use this remedy if:

• hypersensitivity to one or more components;
• cardiogenic shock;
• renal failure;
• severe liver failure;
• angle-closure glaucoma;
• arterial hypotension;
• prostate adenoma.

Medication treatment should be approached with caution by those who are familiar first-hand with such a diagnosis as severe atherosclerosis of the coronary arteries. Since Drotaverine contains milk sugar monohydrate, it is also contraindicated for:

• congenital lactose intolerance;
• glucose-galactose malabsorption;
• lactase deficiency.

Drotaverine should not be given to children under three years of age. At this age, the risk of side effects is highest. The medicine does not affect embryonic development in any way. At least the opposite has not been proven. However, Drotaverine during pregnancy is prescribed only in exceptional cases - when it is impossible to do without the drug. Doctors do not recommend it for nursing mothers either.

Contraindications

Common to both dosage forms:

1. Increased individual sensitivity to the components of the drug.
2. Severe heart failure, severe arterial hypotension, atrioventricular block II-III degree. The drug is also contraindicated in patients with cardiogenic shock.
3. The drug is contraindicated in patients suffering from severe renal and/or liver failure.
4. The drug in the form of tablets Drotaverine and Drotaverine Forte contains lactose, so it should not be used to treat patients with congenital lactase deficiency, as well as glucose-galactose malabsorption syndrome.
5. The drug in tablet form Drotaverine Forte is not used to treat children under 12 years of age.
6. The drug, regardless of the form of release, should be prescribed with caution to patients suffering from prostatic hyperplasia, angle-closure glaucoma and atherosclerosis of the coronary arteries, as well as patients with suspected atherosclerosis of the coronary arteries.
7. The drug should be prescribed with caution to women during pregnancy and lactation.
8. The drug is not recommended for use in patients whose work involves operating potentially dangerous machinery or driving a car. If it is necessary to prescribe the drug, you should refrain from work requiring increased attention for an hour after taking drotaverine.

During pregnancy: the drug penetrates the hematoplacental barrier, so its use during pregnancy is possible only if the expected benefit to the mother is higher than the potential risks to the fetus.

If it is necessary to use the drug during lactation, the issue of possible interruption of breastfeeding should be addressed.

Find out what your blood pressure should be during pregnancy.

Use of tablets

How to use Drotaverine tablets correctly? An overdose will not occur if you follow the doctor's prescription or instructions. The annotation states that children over 12 years of age and adult patients are prescribed 40-90 mg three times a day. One tablet contains 40 mg of drotaverine. This means that a single serving for an adult is from 1 to 2 tablets. The daily dose should not exceed 210 mg of the drug (5.5 tablets).

Children under 12 years of age can take 20 mg of the active substance at a time, which corresponds to half a tablet. The maximum daily portion for them will be 200 mg of the drug (5 tablets).

For children under 6 years of age, medication is prescribed according to body weight. But the instructions say that a single serving should not exceed 10-20 mg of the drug (1/4-1/2 tablet). The daily norm for children will be 120 mg of drotaverine (3 tablets).

The frequency of use of the medication in children is determined by the doctor in accordance with the indications. The instructions describe that you should not use the drug more than 1-2 times a day.

"Drotaverine": overdose

If you take the medicine in large quantities, it can lead to unpleasant symptoms. What are the signs that you are using Drotaverine medication incorrectly? Overdose has the following symptoms:

• feeling of nausea, fullness of the iliac region, vomiting;
• bowel dysfunction: abdominal discomfort, diarrhea, constipation;
• appearance of weakness: pale skin, dizziness, fainting;
• artioverticular blockade: failure of the heart, tachycardia, circulatory disorders;
• paralysis of the respiratory center and cardiac arrest.

If you discover the corresponding symptoms, you should immediately seek help from a doctor. Call an ambulance.

Drug interactions

When prescribing, you need to take into account the properties of the drug in question, which appear when combined with other drugs, thereby reducing the risk of complications.

With other drugs

The intensity of the effect of Levodopa on the body decreases, at the same time the antiparkinsonian effect is weakened.

The drug in question inhibits Morphine's ability to provoke spasms.

The antispasmodic effect of a number of drugs and substances is enhanced: M-choline blockers, Bendazole, etc.

A more pronounced decrease in blood pressure is observed when used simultaneously with tricyclic antidepressants, Procainamide, and Quinidine.

Under the influence of Phenobarbital, the effectiveness of Drotaverine increases.

Alcohol compatibility

There are no strict restrictions, which means that it is allowed to take the drug in question along with drinking alcoholic beverages. However, there is a risk of developing negative phenomena that are not described in the instructions for the product.

Infection Solution is a group of prescription medications.

How to take Drotaverine

The dosage is selected based on the patient’s age, the course of the disease and the severity of the pain syndrome. For acute pancreatitis, injections are given. The medicine is administered intramuscularly in 2 ml doses. The frequency of use is twice a day. The drug can be used intravenously. In this case, the liquid is mixed with saline in a ratio of 1:3.

For acute pancreatitis, the drug Drotaverine is administered intramuscularly, twice a day.

Before or after meals

It is not recommended to chew the tablet. It is better to swallow with plenty of water. The product should be taken 1-2 hours after eating.

If the patient has an acute course of pancreatitis, then taking the medicine should not exceed 3 days. In the chronic form of the disease, a single dose is enough to get rid of the pain.

For cramps, tablets can be given to children over 2 years of age. The dose of the drug depends on age:

• from 2 to 6 years – 10-20 mg twice a day;
• from 6 to 12 years – 20 mg up to 2 times a day;
• over 12 years old – 40 mg twice a day.

1-2 ml of medication is administered intramuscularly 1-3 times a day. IVs are not placed.

When is Drotaverine prescribed?

The drug relaxes the walls of blood vessels running in the bronchi and digestive organs. By inhibiting the enzyme phosphodiesterase, the entry of the active form of calcium into muscle cells is blocked. Thanks to this, the blood vessels dilate, their lumen increases, and oxygen more actively enters the tissues. Drotaverine reduces the synthesis of prostaglandins - substances that stimulate smooth muscle contraction.

The drug helps with pathologies:

• headache, migraine;
• high blood pressure;
• spasm of the gastric sphincters;
• algomenorrhea - painful menstruation;
• renal colic (urolithiasis);
• hepatic colic (gallbladder stones);
• for chronic cholecystitis with increased motility and the postoperative period after removal of the gallbladder;
• intestinal spasms of various origins, hypermotor colitis;
• intestinal colic;
• coronary (heart) and cerebral spasms.

Read how an overdose of Ketorol manifests itself: the consequences of poisoning.

Find out how Ibuprofen poisoning develops: symptoms, assistance to the victim.

Drotaverine is widely used by obstetricians for the threat of premature birth, postpartum contractions, and increased uterine tone during pregnancy. The drug helps relieve spasms and discomfort during instrumental studies, for example, during gastroscopy.

Side effects of Drotaverine most often develop with intravenous and intramuscular administration. Some patients experience hypotension, dizziness, arrhythmia, and tachycardia. With increased sensitivity, an allergy to the components of the product develops: dermatitis, skin rash, which is a contraindication for its use.

Note! The drug is prescribed with caution for bronchial asthma, since paralysis of the respiratory muscles may occur. Antispasmodic is contraindicated in glaucoma.

Side effects from Drotaverine

Negative reactions rarely develop with a properly selected treatment regimen.

One of the side effects of the drug is a decrease in blood pressure.

Possible side effects:

1. increase in heart rate;
2. decrease in pressure level;
3. deterioration in sleep quality;
4. headache;
5. dizziness;
6. difficulty passing stool;
7. nausea;
8. allergies accompanied by itching, Quincke's edema, rash;
9. Anaphylactic shock rarely develops; there is information about cases of death as a result of this.

Symptoms of Drotaverine poisoning

Since the drug is almost completely absorbed from the gastrointestinal tract, symptoms of overdose appear quite quickly. After 45–50 minutes, its concentration in the blood reaches its maximum. Drotaverine poisoning is manifested by symptoms:

• weakness;
• interruptions in the heart area;
• foggy consciousness, dizziness, fainting;
• vomiting and nausea;
• drop in blood pressure;
• muscle cramps.

A dangerous complication is atrioventricular block - a violation of the transmission of nerve impulses from the atria to the ventricles. In this case, the atria pump blood to the ventricles, but the latter are not able to deliver it to the brain and internal organs. The pulse rate slows down depending on the dose of the drug taken and can range from 20 to 40 beats per minute. A bluish color of the skin, pain in the heart, and shortness of breath appear. In severe cases, a person loses consciousness and experiences convulsions.

Important! If an overdose of Drotaverine occurs, death quickly occurs from paralysis of the respiratory center and cardiac arrest.

Indications for use

Before prescribing a drug, the specialist should make sure that the patient does not suffer from hypersensitivity to the drug. The main indication for its use is to eliminate spastic pain of various origins, which can be caused by the following types of diseases:

• cholecystitis;
• stomach and duodenal ulcers;
• constipation, which is accompanied by spasms of intestinal smooth muscles;
• intestinal colic with increased gas formation;
• urethritis, cystitis;
• proctitis with severe pain;
• urethrolithiasis, nephrolithiasis, pyelitis.

In case of the above pathological phenomena, the drug is prescribed, as a rule, as an anesthetic drug, which is part of the complex therapy of the underlying disease.

Drotaverine composition

The active ingredient is drotaverine hydrochloride. To form drug tablets, the composition includes fillers starch, talc, milk sugar, collidons, and magnesium stearate.

The medicine is used in conditions where a pronounced antispasmodic effect is needed. Relieving tension in the walls of the abdominal organs, gastrointestinal tract and blood vessels, it stops their activity and eliminates pain. Does not affect the cardiovascular system; the effect of the drug is not sufficiently pronounced.

What is the drug used for? It is needed to reduce tension and eliminate spasm of the muscles of the abdominal organs during:

• gallbladder diseases,
• ulcers of the stomach and duodenum,
• spasms of the stomach muscles:
• colitis,
• flatulence and associated colic,
• cystitis and urethritis,
• prostatitis,
• renal colic,
• in gynecology to stop threatened premature birth,
• for headaches,
• to facilitate the diagnostic process.

Indications for use of the drug for humans are symptomatic, distractive treatment to relieve the main symptoms and relieve pain.

Special instructions for use

When the solution is injected internally, to prevent collapse, the patient should be in a horizontal position. When using the drug, especially in solution form, people should limit their vigorous activity for 1 hour after administration of the drug. This applies to potentially dangerous actions that require concentration, rapid psychomotor actions, etc.

During the treatment of gastric and duodenal ulcers, the prescription of "Drotaverine" is combined with the use of antiulcer medications.

In addition, when taking the drug as part of complex therapy, you need to know about the compatibility of Drotaverine with other drugs. If the patient is administered Phenobarbital with Drotaverine at the same time, the antispasmodic effect of Drotaverine will increase.

In addition, the drug has the following effects in some situations:

1. The antiparkinsonian effect of levodopa becomes weaker.
2. The spasmogenic activity of morphine under the influence of Drotaverine is reduced.
3. Increases the effect of bendazole and other antispasmodics.

Rules for taking tablets and solution

The tablets should be taken orally with water. Do not chew or crush the medicine before taking it. An exception may be children who cannot swallow a whole tablet. In this case, you can grind the medicine into powder and dilute it in a small amount of water.

The instructions do not indicate when to take the product - before or after meals. But many doctors recommend taking the medicine after meals. If the meal was taken a long time ago, then before taking the Drotaverine tablet you can eat an apple, a banana, a small sandwich, etc. That is, there may be little food, the main thing is that the medicine is not taken on an empty stomach.

The duration of the therapeutic course is determined by the attending physician.

The dosage of "Drotaverine" for adults is as follows: 1-2 tablets three times a day, while the maximum dose per day should not exceed 240 mg.

For children:

1. From 3 to 6 years – 40-120 mg, divided into 2-3 doses. You can take a maximum of 120 mg per day, dividing this dose into several doses.
2. From 6 to 12 years - 2-5 tablets, which are also divided into several doses per day. The maximum dose per day is no more than 200 mg.

If we talk about the solution, it is administered subcutaneously or intramuscularly at 40-80 mg from one to three times a day. For each dose, 2-4 ml of medication is administered.

There are special instructions for the prevention of renal or hepatic colic. In this case, the solution should be administered slowly, 40-80 mg intravenously.

All treatment regimens outlined are considered conditional and formulaic. Only a doctor can determine at what dose the medicine is indicated for the patient, depending on the specific case.

Interaction with other drugs

Drotaverine enhances the therapeutic effect of papaverine and other antispasmodics, including m-anticholinergics. Reduces the pharmacological activity of morphine and levodopa. When taken simultaneously with phenobarbital, the latter enhances the effects of Drotaverine. Prescribing the drug with novocainomide, quinidine, tricyclic antidepressants can lead to a critical decrease in blood pressure.

Prescription of medication

To avoid an overdose of Drotaverine, you must read the instructions before using the product. Pay attention to the indications for which the drug is prescribed. Its correct use will prevent an overdose. What does medicine help with and in what cases is it necessary for a person?

• For spasms of the smooth muscles of the digestive tract (biliary, renal or intestinal colic).
• Cholecystitis, pyelitis, obstruction of the biliary tract.
• Spastic colitis and constipation, pylorospasm and proctitis.
• Ulcer of the stomach or duodenum in the acute stage (used in complex therapy).
• Spasms of the coronary, peripheral and cerebral arteries and vessels; endarteritis.
• Algomenorrhea, premenstrual syndrome.
• Prolonged labor, threatened abortion, spasm of the uterus during childbirth, postpartum contractions.
• Before instrumental examinations in order to relax muscles and dilate blood vessels.
• In complex therapy for the treatment of febrile conditions (as part of a lytic mixture).

All of these cases should be reviewed by a doctor. The doctor also prescribes the drug after examination.

Overdose

If you do not take into account the recommendations for taking the drug and increase the amount of the drug at your discretion, the following symptoms may appear:

1. disturbance of atrioventricular conduction;
2. the ability of the heart muscle to contract is lost, which can lead to cardiac arrest;
3. paralysis of the respiratory system due to the intense relaxing effect of the drug.

An overdose of the drug provokes a loss of the heart muscle’s ability to contract, which can lead to cardiac arrest.

The main therapeutic measure is aimed at removing excess Drotaverine - gastric lavage (if tablets were used). The functions of organs whose functioning has been disrupted are artificially supported.

What you need to know about intoxication?

In case of drug poisoning, symptoms begin to develop after 30 minutes. One of the basic causes of drotaverine poisoning is accidental or intentional significant excess of the dose.

However, when taking other drugs together, for example, phenobarbital and drotaverine, an overdose is likely due to the increased therapeutic effect of the latter.

Dosage regimen

When taking, consider compatibility with other drugs

When taken orally, the tablets should be swallowed whole, without chewing, and washed down with plenty of water. The timing of meals does not affect the therapeutic effect of the drug.

The dosage of drotaverine indicated in the instructions is as follows:

• adults and children over 12 years old - 1-2 tablets (40 mg or 80 mg of active ingredient) 2-3 times a day;
• children aged 6 to 12 years - 1/2 tablet no more than 2 times a day;
• children aged 2 to 6 years - 1/4 tablet no more than 2 times a day.

The maximum daily intake for adults should not exceed 6 tablets.

When administered intramuscularly, the patient should be in a lying position to avoid the development of collapse. The introduction itself should be done slowly. In doing so, comply with the following standards:

• adults and children over 12 years old - 2-4 milliliters, no more than 3 times a day;
• patients with renal and/or liver failure - 2-4 ml, dissolved in 5-10 milliliters of 0.9% sodium chloride solution.

Intra-arterial administration is indicated for patients with peripheral circulatory disorders caused by spasms of the vascular layer of smooth muscle tissue.

It is important to know how many tablets can cause death.

Some medical sources contain information based on real cases and indicate a lethal dose of 40-60 tablets (40 mg each). Death occurred within 2-3 hours, which is due to the high absorption and bioavailability of the drug.

The negative consequences of combining drotaverine with alcohol are associated with the muscle relaxant effect of both drugs on muscles. In this case, the consequences will be expressed in the fact that the person will not be able to move independently. The only advantage in this situation is that the drug reduces the absorption of alcohol and its antidepressant effect.

However, the consequences can be much more serious, leading to death.

Symptoms of toxemia

Although an overdose of drotaverine is a very rare phenomenon, it is still possible. In this case, the following signs appear:

hypotension;

Dizziness and loss of balance in movement due to overdose

In especially severe cases, respiratory and cardiac activity may stop.

Consequences of an overdose of Drotaverine

If an overdose of Drotaverine occurs, the consequences depend on the amount of the drug taken and the reserve capabilities of the patient. When a person deliberately took a large number of pills and was not given first aid, the result can be sad - death. The development of heart failure, chronic kidney and liver pathology is possible.

The drug has a pronounced antispasmodic, hypotensive and vasodilating effect and is used to treat many diseases. If you follow your doctor's recommendations, it rarely causes side effects. To avoid serious consequences, be sure to read the instructions before using it.

Instructions for use of Drotaverine (Method and dosage)

The medicine is prescribed to adults three times a day orally, 40-80 mg. No more than 240 mg.

40-80 mg is administered subcutaneously and intravenously 1-3 times a day. In order to relieve renal and hepatic colic, 40-80 mg is administered intravenously slowly. Intra-arterial administration is acceptable for peripheral vascular spasm.

Children from 3 years to six years of age can be administered 10-20 mg at a time, no more than 120 mg per day. 2-3 doses per day are acceptable.

An overdose is manifested by impaired atrioventricular conduction, paralysis of the respiratory center, cardiac arrest, and decreased excitability of the heart muscle.

The tablets are intended for oral administration, regardless of food intake. It is recommended to take the tablets with 200 ml of boiled or still mineral water. The dosage depends on the severity of pain and the age of the patient:

• children from 2 to 6 years old - 1/4 tablet no more than 2 times a day;
• children under 12 years old - ½ tablet 1-2 times a day;
• adults and adolescents - 1-2 tablets no more than 3 times a day.

The maximum daily dose of the drug for adults is 240 mg, i.e. no more than 6 tablets per day. The course of treatment is determined by the dynamics of the disease and averages 10-15 days.

Taking overdoses of an antispasmodic is fraught with impaired myocardial contractile function, paralysis of the respiratory centers and a decrease in atrioventricular contractility. The most pronounced signs of overdose include:

• shallow breathing;
• tachycardia;
• chest pain;
• loss of consciousness;
• mydriasis

If atrioventricular block develops, the patient is prescribed isoprenaline and atropine. In case of cardiac arrest, intravenous administration of adrenaline is indicated to stimulate myocardial contraction.

Orally, adults: 40–80 mg 3 times a day. Children: up to 6 years old - 10-20 mg 1-2 times a day, 6-12 years old - 20 mg 1-2 times a day.

Signs of overdose

Symptoms of poisoning appear within half an hour after taking an excessive amount of medicine.

The victim’s blood pressure decreases, tachycardia is observed - the heartbeat increases to three hundred beats per minute.

The patient feels dizzy, his vision becomes dark, and his coordination is impaired. The speed of the psychomotor reaction decreases.

The poisoned person may also suffer from convulsions or tremors of the limbs. He lacks air, his general condition is weakened. In addition, a person’s sleep is disturbed - he is either overcome by drowsiness or suffers from insomnia.

There is a dry mouth. The functioning of the gastrointestinal tract is disrupted: the patient feels sick and vomits. There are constipations.

Allergic reactions to the drug taken, such as fever, itching, and rash, may also occur.

In the most severe case of poisoning, the heart stops beating, breathing stops, and death occurs.

Video: Drotaverine.

Composition of the drug "Drotaverine"

Drotaverine hydrochloride is the main component of this medication; each tablet contains 40 mg of this substance. Auxiliary components include:

• lactose;
• potato starch;
• povidone;
• talc;
• magnesium sterate.

Drotaverine is also produced in the form of an injection solution. In this case, the amount of drotaverine hydrochloride in each ampoule is 20 mg.

The injection solution is available in the form of ampoules, each of which contains 20 ml of the main substance. In the form of yellow tablets with a greenish tint - each tablet contains 40 mg of drotaverine hydrochloride.

Reviews about the drug

The medicine is widely used in clinical medical practice, as well as in a variety of diagnostic and therapeutic measures. Due to its high effectiveness, this remedy is used when pain of severe intensity occurs.

Reviews from specialists and ordinary consumers contain information that this medication helps to quickly eliminate pain of various origins. Patients are especially pleased with the effects of the dosage form of this drug in the form of intramuscular injections, through which they can stop any spasm and get rid of pain. Doctors often use Drotaverine to relieve pain after surgery.

The use of this medication has also been described in the event of pain symptoms occurring after various injuries, but given its impact, in such situations its effect was minimal, since Drotaverine is used mainly for pain of spasmogenic origin. Many people don’t know what these pills are for.

As for the side effects of this medicine, patient reviews note that the drug almost never causes symptoms of nausea, dizziness, psycho-emotional disorders, or problems with stool. In some rare cases, such manifestations did occur, but patients noted that the negative reactions were quite mild and did not cause them much discomfort. The use of the drug simultaneously with other medications has also been described in numerous reviews, and patients experienced a slight increase in blood pressure.

In general, we can say about the drug that it is a very high-quality and effective medicine, which at the present stage of development of medicine is widely used not only at home, but also in hospitals.

The article reviewed the instructions for use of Drotaverine tablets.

How long does it last?

After taking the tablets, the effect is observed within 20-30 minutes. The maximum concentration is reached after 45-60 minutes. If the medicine is administered intravenously or intramuscularly, a positive result is observed after 5-10 minutes.

The action of Drotaverine begins 20-30 minutes after taking the tablets.

The therapeutic effect is observed within 2-4 hours. 95% binds to blood proteins. Excreted in urine and bile.