How to take De-Nol correctly according to the instructions for use of the drug?

Among gastrointestinal diseases, the most common ailment is gastritis and ulcerative lesions of the mucous membranes of the stomach and duodenum. Treatment of these pathological conditions should be carried out in combination.

The patient is recommended to go on a diet and, of course, is prescribed medications. One of the most popular remedies is De-Nol. Let's figure out what recommendations for taking De-Nol are given in the instructions for use, what contraindications there are and what side effects may arise during the treatment process.

Description of the product

The main active component is bismuth tripotassium dicitrart. Each tablet contains 304.6 mg. It is this that determines the therapeutic effect of De-Nol: the drug has an enveloping, anti-inflammatory and astringent effect. While taking the medicine, the integrity of the damaged mucosa is restored.

Available in the form of white tablets with a slight cream tint. May have a slight ammonia odor. The tablets are packaged in blisters made of aluminum foil. One package contains 56 or 112 pieces.

Composition and release form

First of all, it is worth getting acquainted with the release form and composition of the drug. It is available in the form of tablets for oral administration. The shape of the tablets is round, the color is white, possibly having a creamy tint. On one side there is a depressed image of a square with rounded edges. The smell is neutral.

The tablets are packaged in foil blisters; there are 8 pieces in one blister; there is a dividing strip that makes it easy to separate 4 tablets, that is, the daily dose of the drug.

Blisters are packaged in cardboard packs of 7 and 14 blisters per package. The small pack is designed for a two-week course of administration, the large pack for a course lasting 28 days.

In addition to blisters with tablets, the package contains an annotation. The active ingredient of the drug De-Nol is a complex bismuth salt, more precisely, bismuth tripotassium dicitrate.

The content of the active substance is indicated in the name; one tablet of De-Nol 120 mg contains, respectively, 120 mg of bismuth salt. The rest of the composition of the drug is represented by excipients, these are:

• corn starch;
• povidone K30;
• magnesium stearate;
• hydroxypropyl methylcellulose and other substances.

De-Nol tablets, according to the instructions for use, are intended for the treatment of ulcerative lesions of the organs of the upper gastrointestinal tract.

Indications for use

The use of "De-Nol" will be justified in the treatment regimen for the following gastrointestinal pathologies:

• ulcers of the stomach and duodenum;
• dyspeptic syndrome;
• irritable bowel syndrome;
• gastritis – the drug is also used for chronic damage to the gastric mucosa;
• Ellison-Zollinger syndrome.

The drug can also be used in the treatment of functional dyspepsia not associated with organic lesions of the gastrointestinal tract

Pharmacological effect

It is important for the patient to understand how the drug used for treatment works. De-Nol (or De-Nol, if the name is indicated in Latin in the recipe) is a drug used in the treatment of diseases of the stomach and duodenum. The action of the drug De-Nol is complex; it is a means of:

• antibacterial;
• antiulcer;
• gastroprotective.

Advice! Despite the fact that the product helps fight infection, De-Nol is not an antibiotic. In the Pharmacological Reference Book, the medicine is included in the section “andacids and adsorbents”.

But, nevertheless, the antibacterial effect of De-Nol has been confirmed by clinical trials. The mechanism of action of the medicine is as follows: complex bismuth salt has a detrimental effect on Helicobacter pylori.

The active substance inhibits the enzyme system of microorganisms. As a result, bacteria lose the ability to move and can no longer damage the walls of the digestive organs.

Advice! An important advantage of De-Nol is that pathogenic microorganisms cannot develop resistance to the action of bismuth salts.

In addition, De-Nol has the following effects:

• binds bile acids;
• enhances the protective properties of the gastric mucosa, as it stimulates the production of mucus, which provides natural protection to the stomach;
• reduces the degree of negative effects of excess hydrochloric acid;
• helps improve blood circulation, due to which metabolic processes accelerate and tissue healing occurs faster;

• the synthesis of the enzyme peptin, which causes irritation of the mucous membrane, is reduced;
• A protective film is formed over the affected areas, which prevents further irritation and growth of erosions.

Contraindications

When treating gastritis with De-Nol, it is necessary to take into account existing contraindications. The drug is completely prohibited for use in cases of diagnosed acute or chronic renal failure and gastritis with low acidity.

Relative contraindications include hypersensitivity to the component composition of the drug. Drinking De-Nol during exacerbation of gastritis during pregnancy is prohibited, since bismuth preparations have a pronounced teratogenic effect. During gestation, it is necessary to use other, safer medications.

Domestic substitutes

All De-Nol analogues are highly effective and have similar indications for use. In this case, the choice of drug must be agreed with the attending physician.

Vikair

This is a complex medication with a multi-faceted effect:

• antacid;
• antiseptic;
• antispasmodic;
• laxative.

The drug is available in pink tablets.
It contains a combination of active ingredients - extracts from calamus root and bismuth nitrate. It has the ability to influence the nerve endings of the gastrointestinal tract, while improving digestion and metabolism. Prescribed orally, one tablet three times a day after meals. The course of treatment lasts at least 3 months. Vikair is indicated for diseases of the digestive system of various etiologies, such as;

• stomach ulcer and duodenitis;
• bloating;
• dyspeptic disorders;
• gastritis.

It should be used with caution with other drugs containing bismuth, since in this case its concentration in the blood increases and the risk of developing encephalopathy increases. A peculiarity of using Vikair is the appearance of black stool after taking it, and increased frequency of stools.

Pregnancy and lactation are a direct contraindication for use.

Novobismol

The medication belongs to the group of intestinal antiseptic and astringent agents. Release form: tablets. The main active component is bismuth tripotassium dicitrate, which protects the mucous membrane of the digestive tract from destruction, maintaining its integrity. It has a pronounced bactericidal and anti-Helicobacter effect.

Features of the drug use

In the presence of erosions and ulcers, it forms films on their surface. In pediatric practice, it is indicated for children from 8 years of age. Prescribed 2 tablets twice a day. Contraindicated during pregnancy and breastfeeding. Compatible with most medications.

Ranitidine

The most famous medication from the group of H2-histamine receptor blockers. The mechanism of its action is based on the regulation of the production of hydrochloric acid in the stomach, as a result of which favorable conditions are created for the healing of ulcers and erosions. It is available not only in tablet form, but also in injection form. The main active ingredient is ranitidine hydrochloride. Taken in an average daily dose of 300 mg - 1 tablet 2 times a day.

Injections are prescribed in extremely severe conditions. Main indications: peptic ulcer and erosive gastritis. A contraindication to the use of Ranitidine is cancer.

Ventrisol

The main constituent substance is bismuth dipotassium dicitrate. Release form: round white tablets, 120 mg of active ingredient. It has a complex antispasmodic and antacid effect on the mucous membrane of the stomach and intestines.

A group of ulcerative lesions of the gastrointestinal tract is the main indication. Contraindicated in the first trimester of pregnancy and in children under 4 years of age. Before prescribing, a thorough examination of the urinary system is necessary.

Escape

Belongs to the pharmacological group of antiulcer drugs. It has an antiseptic, anti-inflammatory and astringent effect. The main effect of the medication is aimed at:

• destruction of the bacterium Helicobacter pylori;
• providing conditions in which it is difficult for a microorganism to develop.

A special feature of Escape is the presence in its composition of povidone, an enterosorbent that can absorb and remove toxins. The product is produced in the Russian Federation by the pharmaceutical concern Optisipharm. Widely used in therapeutic and gastroenterological practice.

Instructions for use

How to take De-Nol for gastritis? First of all, it should not be taken without a doctor’s prescription. The method of use and recommended dosages are indicated in the instructions for use.

The scheme is as follows:

How to cure gastritis with folk remedies?

• Children aged 4–8 years. The norm is calculated based on the patient’s weight: 8 mg per 1 kg. The resulting amount of the drug must be divided into 2 doses and given to the child in the morning and evening.
• Children aged 8–12 years. Dosage – 1 tablet twice a day.
• Children over 12 years of age and adult patients. Dosage – 1 tablet 4 times a day.

It is necessary to take De-Nol for gastritis with high acidity, in particular for erosive and atrophic gastritis, 30 minutes before meals. Take the tablet with plenty of clean water. How long should you drink De-Nol? The full course is 5–8 weeks, but the exact duration is determined by the attending physician.

After completion of treatment, it is prohibited to take bismuth preparations for two months.

Reception scheme

According to the instructions, the medication can be taken according to the following regimens: the tablet is always taken 30 minutes before meals, but the last one at night; 2 tablets before breakfast or before dinner. Chewing the pills is prohibited. You need to drink the product with clean water without gas.

Analogs

There are analogs of De-Nol produced by Russian and foreign manufacturers. Almost complete analogues, having the same composition and equal dosage of the active substance, are:

• Novobismol;
• Escape;
• Vitridinol.

Medicines that have a different composition but have a similar effect are:

• Vikair;
• Venter;
• Vikalin.

Possible side effects

During treatment with the drug, unpleasant symptoms may develop. These are attacks of nausea ending with vomiting, diarrhea or constipation, an allergic reaction - a rash like urticaria, itching, darkening of the stool.

Nausea is one of the likely side effects

Such conditions occur in rare cases and, as a rule, are mild. They disappear on their own and do not require discontinuation of the medication. The development of side symptoms does not affect the therapeutic effectiveness of De-Nol.

Preparations containing bismuth for gastritis and gastric ulcers

All bismuth preparations used in the treatment of these diseases lead to inhibition of the development of the bacterium Helicobacter pylori, protect the affected area from irritation by gastric juice by creating a film, increase the secretion of protective gastric mucus, and also stimulate blood supply to the gastric mucosa and increase its resistance to the influence of hydrochloric acid. A very important factor is that preparations containing bismuth do not cause changes in the properties of gastric juice.

Helicobacter pylori is resistant to some antibiotics, so when treating peptic ulcers caused by this bacterium, they have to be prescribed in combinations and in fairly high doses, which leads to all sorts of adverse reactions, and the desired effect is not always achieved. An alternative in the combined fight against this bacterium is bismuth-containing drugs, since together with antibiotics they suppress Helicobacter and protect the walls of the stomach.

These drugs are almost not absorbed into the systemic bloodstream, and, therefore, have a minor effect on the entire body, which allows them to be used for a relatively long time (but no more than 2 months in a row).

Containing bismuth tripotassium dicitrate, DeNol analogues are often prescribed as part of four-component intensive antibacterial therapy or to consolidate the results obtained, prevent relapses and accelerate the regeneration of damaged gastric or duodenal mucosa. They are used not only in the treatment of ulcers, but also for acute and chronic gastritis in adults and children from four years of age. The duration of the course of therapy, as well as the dosage of medications, is calculated by the attending physician for each patient individually, depending on the course of the process.

Among the most well-known and frequently used analogues of the original product are Novobismol, Ventrisol, Ulcavis. These drugs are not inferior to De-Nol in their properties and therapeutic effect, but at the same time have a lower cost, thanks to which many patients have access to a full course of treatment, which ensures the achievement of a lasting positive result.

Overdose

If the recommended daily doses are exceeded, an overdose cannot be ruled out. Its symptom is a disruption of the renal system. This condition is reversible. Restoration of kidney function occurs after discontinuation of the drug.

Treatment consists of gastric lavage, taking saline laxatives and drugs from the group of enterosorbents. In the future, symptomatic therapy is provided. If, against the background of impaired renal function, a rapid increase in the bismuth content in the blood plasma is recorded, then the patient should receive chelating agents. In some cases, hemodialysis may be required.

Operating principle

The medicine, once in the stomach, quickly dissolves under the influence of an acidic environment. Bismuth tripotassium dicitrate and organ tissue proteins combine to form a film that protects the mucous membrane from the irritating effects of gastric juice for several hours. This film does not cover the entire surface of the mucous membrane, but only those places where there is damage - ulcers and erosions. This effect of the drug does not interfere with the digestive process.

Thanks to the antimicrobial effect of the active component, the drug helps fight Helicobacter pylori. This bacterium often causes stomach diseases. Bismuth tripotassium dicitrate prevents the formation of a bacterial enzyme, which leads to the death of pathogenic microflora.

The drug has another useful property that can reduce heartburn: under the influence of the drug, the process of producing natural mucus is stimulated, which protects the mucous membrane from damage, and the acidity of the juice produced by the stomach is reduced.

De-Nol helps with heartburn only if the patient undergoes a course of treatment. Taking the medicine once will not solve the problem.

After completing the therapeutic course, the acid-base balance of the stomach is restored, blood circulation in this organ improves, and pepsin activity decreases. The result also affects other organs of the gastrointestinal tract - the mucous membranes are covered with a protective film. The medicine has a positive effect on the immune system, metabolic and recovery processes occurring in the body.

Interaction with other drugs

The effect of taking De-Nol may be reduced with the simultaneous use of drugs from the group of antacids, in particular Phosphalugel, as well as fruits, milk and juices. That is why you need to take tablets half an hour before or after meals or before taking any medications. Tetracycline antibiotics are incompatible with De-Nol, since they reduce the rate of their absorption.

"De-Nol" cannot be combined with alcohol intake

How to drink "De-nol" for gastritis

Instructions for use for gastritis stipulate at what age and how to take the drug. The use of "De-nol" is allowed for children over 14 years of age. In addition, in special cases this drug is prescribed to young children.

It is prohibited to give the drug to a child on your own without a doctor’s prescription, since bismuth is classified as a heavy metal, and it has a toxic effect if used incorrectly.

"De-nol" for gastritis is taken, as a rule, as part of complex therapy. Along with it, when prescribing therapy, proton pump inhibitors, antacids or drugs that improve motility are prescribed.

For concomitant diarrhea, antidiarrheal drugs are prescribed, and for constipation, medications that have a laxative effect are prescribed.

The presence of Helicobacter pylori means supplementing De-nol with one or more antibiotics that affect this microorganism.

For the most effective effect of the drug, you must adhere to the following rules and methods of administration:

1. Do not chew or crush the tablets;
2. It is allowed to take tablets only with settled, clean or boiled water;
3. while taking the drug or immediately after it, it is not recommended to consume milk, dairy and fermented milk products - this reduces the effectiveness of treatment with De-nol;
4. after taking the product, you should not eat food, drink fruit juices, compote, tea, coffee, or alcoholic beverages;
5. “De-nol” is consumed half an hour before meals; after consuming the drug, you should not take other medications for 30-40 minutes;
6. after completing the course of therapy, for several months you should not use other products containing bismuth as an active substance, in order to avoid its accumulation in the tissues of the body;
7. During treatment with De-nol, the daily doses of the drug prescribed by the treatment regimen should be followed so as not to provoke side effects.

The duration of the course of treatment is determined individually by the doctor, usually its duration is from one month to two.

The therapeutic dosage of the drug depends on the exact diagnosis, the patient’s age, and body weight (in children).

It is recommended to take one dose at night; for convenience, the daily dose can be divided into two doses (morning and evening). The average duration of the treatment course is 2-4 weeks.

Before starting to take the medicine, the doctor recommends changing your diet and daily routine: the patient should sleep 8 hours a day and eat at the same time strictly in accordance with the “Table No. 2” diet 4-5 times a day. At the same time, junk food, too hot or too cold dishes are prohibited.

Typically the following dosage is used:

• from 4 years old. The dosage is prescribed depending on the patient’s weight (8 mg/kg) and is taken in 2 doses, the child drinks 4 mg/kg at a time.
• from 8 years: take one tablet in the morning and evening.
• over 12 years old. Taking into account the stage of the disease and body weight, 3-4 tablets are prescribed. When prescribing 3 tablets, it is better to take them in the following way - drink 2 in the morning and 1 at night, when prescribing 4 tablets - distribute the dose evenly and drink 2 tablets at a time.
• adults - 1-2 tablets with each meal (half an hour before eating).

"De-Nol" - an antibiotic or not

The drug has antimicrobial properties, but it is not included in the group of antibiotics. Due to the presence of bismuth in De-Nol, it is actively included in the treatment regimen for Helicobacter pylori infection, which significantly increases its effectiveness.

The use of the medication helps protect the mucous membrane from the aggressive effects of gastric juice and accelerates its healing process. A similar effect is achieved by converting the drug into a colloidal solution. Its particles cover the ulcerated areas with a dense film, which not only stimulates the healing process, but also prevents the formation of a rough scar.

Composition of De-nol

If De-nol can be taken even by children, then what components are included in its composition and ensure safe treatment.

• colloidal bismuth subcitrate;
• corn starch;
• polacrinil potassium;
• povidone;
• macrogol;
• magnesium stearate;
• hypromelose.

So, I’ll tell you honestly that I didn’t understand anything. It is possible for people with medical education to interpret and understand the composition. It’s good that reviews from specialists were on the site and thanks to them you can understand whether this medicine is worth attention.

“ Unfortunately, gastritis and ulcers have become too common.
People self-medicate, thereby aggravating the disease. Do not forget that if treatment is not prescribed in time, the disease will progress and can lead to a disastrous outcome. The drug De-nol is one of the best currently available. I prescribe it to my patients and I am very pleased with the results. The advantage of this product is its bactericidal effect on the bacterium Helicobacter pylori, which causes disruption of the stomach. ” Anton Viktorovich, gastroenterologist, St. Petersburg.

Almost all the expert reviews that I found were in favor of De-nol. Doctors note a rapid improvement in his condition. Relief occurs after just a few doses, and a full course allows you to get rid of not only the symptoms, but also the cause of the disease.

Reviews

People's reviews of De-Nol are mostly positive. The drug copes well with the pathological symptoms of the disease.

Olga: I have suffered from gastritis since school. The disease became chronic. I took many different medications. The analysis showed that the cause of my gastritis was Helicobacter pylori. The gastroenterologist prescribed a different treatment regimen, which included De-Nol. The symptoms of the disease went away very soon, and the gastritis itself went into remission.

Evgeniy: I went to the doctor with stomach pain. It turned out that it was gastritis, and the culprit was Helicobacter pylori. The doctor prescribed De-Nol. I took the drug for two weeks. It helped a lot.

Svetlana: My gastritis was caused by Helicobacter pylori. The gastroenterologist prescribed several medications to take at once. Among them was “De-Nol”. Treatment with it helps a lot.

The medicine also received good reviews from doctors. The maximum effect is shown by the combination of De-Nol with Omeprozole, Trichopolum and an antibiotic (Clarithromycin or Amoxicillin). It is important to remember that the medication effectively treats gastritis caused by Helicobacter pylori infection.

Feedback from customers who took De-nol

After reading the ingredients and reviews from specialists, I realized that the medicine could really help me with my problem. But a certain amount of mistrust in the depths of my soul did not leave me, I just needed to hear reviews from people who took a course of the drug and could tell me whether it was worth buying it or whether it was just money down the drain.

Fortunately, you can find everything on the Internet; I read many opinions about De-nol on various forums. Some took it for two months, and others for three weeks, but in the end everyone had the same result - the medicine helped.

“I started having stomach problems when I was twenty, and since then I have suffered from terrible discomfort and pain. I tried many medications, there were some that relieved pain well, but after a while the spasms appeared again. My brother recommended De-nol to me, he says that it’s the only way he can be saved. I took the whole course and it really became much easier for me. My stomach stopped hurting and after a long diet, I was finally able to gradually try foods that I had not eaten for a long time. The price is not cheap, but it's worth it. It's like I was born again. Very pleased with the result! ”

And there are a lot of similar reviews. People praise the antispasmodic effect of the drug due to its enveloping effect. In addition, by taking De-nol in combination with other medications, many were finally able to get rid of the Helicobacter pylori bacterium and improve the functions of the digestive tract.

Indications

Instructions for use of De-Nol provide the following indications:

• acute, chronic form of gastritis, gastroduodenitis;
• peptic ulcer of the duodenum, stomach;
• functional dyspepsia syndrome;
• irritable bowel syndrome.

Despite the fact that the drug has virtually no contraindications, it can only be taken after consultation with a doctor. De-Nol is often used to prevent seasonal exacerbations and prevent infection with the Helicobacter pylori bacterium.

Fact! The drug combines well with penicillin and macrolide antibiotics, which are also effective for stomach ulcers and chronic gastritis associated with Helicobacter pylori infection.

It can also be used in the following cases:

• pulpitis;
• duodenitis;
• dyspeptic disorders;
• chronic diarrhea;
• malabsorption of nutrients.

De-nol for atrophic gastritis is considered one of the safest drugs. It is necessary for exacerbations of chronic diseases. A gastroenterologist can prescribe it for bacterial inflammations and erosions that appear after long-term treatment with other drugs.

De-Nol for gastritis

Treatment of gastritis should always be comprehensive: diet, normalization of lifestyle and regular use of medications. Before prescribing therapy, the doctor refers the patient to gastroscopy, which can be used to determine the form of gastritis and the level of acidity of gastric juice.

De-Nol is used for gastritis only if a pathogenic strain of Helicobacter pylori is detected in the stomach cavity, as well as a high concentration of hydrochloric acid. In this case, the drug will protect the inner wall of the stomach from the aggressive environment of digestive juice and suppress the growth of bacteria.

De-Nol can be taken in two ways:

1. 2 tablets in the evening and in the morning half an hour before eating.
2. One tablet three times a day, 30 minutes before meals and before bedtime.

Chronic inflammation of the stomach has several varieties, one of which is atrophic gastritis. De-Nol is sometimes included in his treatment. But one drug containing bismuth will not be enough for effective therapy.

The doctor may prescribe additional medications to the patient:

• Abomin;
• Acidin-pepsin;
• Limontar;
• Plantaglucid.

For stomach ulcers

Since in most cases the etiological factor of peptic ulcer is Helicobacter pylori infection, De-Nol is often included in eradication therapy (removing microbes from the body).

Together with other drugs (antibiotics, antisecretory agents), De-Nol treats infection, relieves pain and reduces signs of inflammation in the stomach or duodenum.

For stomach ulcers, the drug is prescribed in a standard dose (one tablet 4 times a day) for a period of 2 or 4 weeks. The duration of therapy can only be adjusted by a doctor.

For gastroduodenitis

Gastroduodenitis is a combined inflammation of the mucous lining of the stomach and duodenum. The disease is accompanied by symptoms similar to chronic gastritis. If H. Pylori was detected during gastroscopy, then tripotassium dicitrate can be added to the treatment.

For gastroduodenitis (during an exacerbation), the medicine should be taken half an hour before meals with a small amount of water. The optimal frequency is 4 times a day, one tablet or twice a day, 2 tablets.

For reflux esophagitis

Since De-Nol has a protective effect on the mucous membranes of the gastrointestinal tract, it is also successfully used for reflux esophagitis, when inflammation in the esophagus develops against the background of constant reflux of stomach contents.

The medication may be part of the treatment of frequently recurrent GERD, when antisecretory, sedative and prokinetic drugs are not effective. But heartburn is not a direct indication for the use of bismuth; such a decision can only be made by the attending physician.

In which cases the medicine is prohibited, it is recommended to read the instructions or article - contraindications to the use of De-Nol.

Mechanisms of therapeutic effects

In terms of composition, this medication is a single drug: the instructions for use accompanying De Nol name one active substance, however, it has multiple effects. This is a complex salt: bismuth subcitrate. Once in the stomach, the medicine goes into colloidal form (as opposed to simple salts). The dosage form of the drug De Nol is tablets: instructions for use indicate that each of them contains 304.6 mg of the active substance.

The effects of antibacterial therapy with De Nol have been well studied: analogues containing bismuth show a less pronounced eradication (bacteria-destroying) effect. The medicine directly binds to the membrane of the pathogenic bacterium and inhibits the enzyme system.

The bacterium becomes immobilized, loses its ability to penetrate the wall of the gastrointestinal tract, and then swells and undergoes cytolysis. The colloidal form of the drug allows it to penetrate the gastric mucus, pits, and also interact with the epithelial layer and enter the cells, destroying the pathogenic agents located there.

Unlike antibiotics, which are partially analogues of the drug De Nol, the formation of resistant bacterial strains does not occur to this drug. In addition, it prevents the emergence of drug-resistant microbes by reducing the level of spontaneous mutations in the bacterial genome.

The mechanism of the cytoprotective effect of the drug on the mucous membrane has been identified. Colloidal bismuth is capable of forming a protective “film” on the surface of erosive and ulcerative lesions by binding to the proteins of the submucosa. This film temporarily replaces the missing epithelium; the wound healing process occurs underneath it.

The active substance of the drug acts as an adsorbent, binding bile acids and inactivating gastric enzymes and proenzymes. The amount of mucus that protects epithelial growth factors (EFG, TFG), which accumulate in the ulcer area and promote regeneration, increases. Another mechanism is due to the fact that the drug is able to locally increase the synthesis of prostaglandin E2 (by 50%), the synthesis and secretion of bicarbonates and mucus.

The result of the drug's action

The result of the drug’s action is not only the regeneration of the epithelium, but also the restoration of microcirculation and stimulation of angiogenesis. The main cytoprotective effects are indicated in the “Pharmacodynamics” section of the instructions for use describing De Nol: analogues with a similar effect belong mainly to the group of antisecretory agents and are less effective.

After getting acquainted with the range of effects in the instructions for use accompanying De Nol, the price of the medicine, exceeding 900 rubles (for 112 tablets), seems quite reasonable.

Side effect

When taken correctly, side symptoms develop infrequently. The most common of these is black stool. This is not dangerous and will go away after completing the course of treatment without additional treatment.

But if taken incorrectly, signs of an overdose may appear; this condition is considered very dangerous and can cause serious consequences. Therefore, it is necessary to take the drug strictly according to the regimen given in the instructions or recommended by the doctor.

More information about the drug "De-nol"

“De-nol” is used for diagnosing chronic gastritis or gastric ulcers in the acute stage, for irritable bowel syndrome, prolonged diarrhea, dyspeptic disorders of various origins, for the prevention of gastrointestinal diseases.

The prescription of “De-nol” is made exclusively by a doctor, since the drug cannot be used for all types of gastritis, for example, the medicine is not prescribed for acute gastritis.

The drug "De-nol" is available in the form of film-coated tablets. The active ingredient in De-nol is bismuth tripotassium dicitrate. De-nol has a strong enveloping, anti-inflammatory, astringent, and antiseptic effect.

The high effectiveness of the drug lies in its ability to accelerate the recovery process. When using De-nol, the mucous membrane is quickly restored, and damaged areas acquire an almost original appearance.

What does the medicine affect? When taking the drug, many processes occur:

• compaction of the top layer of areas damaged by erosion;
• activation of the regeneration process;
• protection of the walls of the digestive tract from the negative influence of an aggressive environment (acid, bile, enzymes);
• reducing the acidity of gastric juice and regulating the production of hydrochloric acid;
• reduction of pain and inflammatory reaction in the damaged area;
• elimination of dyspeptic symptoms: heartburn, nausea and belching;
• reducing the number of relapses and exacerbations.

How does the mechanism of action occur? When the tablet enters the stomach, it begins to act - it reacts with gastric juice, and the process of precipitation of insoluble bismuth salts occurs, which interact with proteins and form foamy compounds on the surface layer of the organ mucosa.

A protective whitish film forms on damaged areas of the mucosa, which remains for several hours. This process prevents the negative effects of aggressive biological substances - hydrochloric acid, bile, enzymes - on the intestinal and gastric mucosa with increased acidity.

The drug stimulates the production of prostaglandids, which promotes the growth of the synthesis of mucin (mucus) and other compounds that improve the properties of gastric secretions. In places of erosion, restoration processes are stimulated. “De-nol” is resistant to the influence of hydrochloric acid, which means it reliably protects the body and does not require additional exposure.

In addition, the medicine has a very important property: antibacterial, which is very important provided that the causative agent of the disease is the bacterium Helicobacter pylori.

De-Nol for prevention: does it make sense?

The course of gastritis and peptic ulcer is chronic. Periods of exacerbation are followed by remission. A connection between the deterioration of the condition and the spring-autumn loss of immune defense and vitamin deficiency was revealed. Patients themselves feel increased pain during hard work, anxiety, or refusal to diet.

Prophylactic administration of De-Nol helps prevent another exacerbation. You can start drinking it without waiting for pain: in March and October, if you plan a stressful load in advance. Timely mechanical protection of the mucosa maintains the epithelium in a normal state. Moderate antacid effects reduce the negative effects of excess acid.

Dosages and regimen of use

De-Nol drink 1 tablet. 4 times a day - half an hour before main meals and in the evening before bed, without chewing, and with a sufficient volume of water (approximately 100 ml). The tablets should not be chewed. An alternative regimen involves taking 2 tablets. 2 times a day – in the morning and evening hours.

The medicine is intended for course therapy. Its duration is from 4 to 8 weeks. Longer use can cause the accumulation of bismuth in the body with the development of symptoms of chronic intoxication.

pharmachologic effect

The drug De-Nol is a gastroprotector that protects the intestines and stomach from the effects of Helicobacter and normalizes their activity, promoting the rapid healing of resulting wounds. The mechanism of action of the drug is based on the destruction of microbes and the protection of the mucous membrane of the intestines and stomach. In the table, you can consider in more detail the mechanisms by which this or that process occurs.

Nuances when using

There are some rules and nuances that are worth paying attention to. For example, Bismuth, which is the main ingredient in DeNol, causes stool to turn black.

In this case, you should urgently consult a doctor.

Within half an hour you must stop drinking milk and other medications. The problem is that De-Nol requires copious amounts of gastric juice.

In the presence of vegetative-vascular dystonia, it is necessary to limit the time of use of the drug. If you follow the rules for using medications, the likelihood of an overdose is very minimal.

Analogues of De-Nol

Taking the drug for two months is necessary to complete the course of treatment. But this drug is considered expensive, and it can be replaced with cheaper analogues.

For example, Novobismol, Ventrisol, Bismuth tripotassium dicitrate.

Conclusion

If you have diseases of the gastrointestinal tract, you should consult a gastroenterologist. An excellent option would be to take De-Nol.

But you must take it following the instructions. You should not take more than 4 tablets per day for adults and 2 tablets for children.

Application for children

For children over four years of age, the dosage is selected as follows: per 1 kg of child’s weight - 8 mg per day, that is, on average, 1.5 tablets per day are needed.

The dose should be calculated as accurately as possible in accordance with body weight. It is possible to divide the total daily dose into several doses, or a one-time dose.

Children over 9 years old are recommended to take one tablet twice a day. As in adults, in children the course of treatment should be no more than 7-8 weeks.

Price

You can order bismuth tripotassium dicitrate at a pharmacy or buy it at an online pharmacy. The price of a medicine depends on the policy of the point of sale, the manufacturer and place of residence. You can buy De-Nol without a prescription at an average cost of 390 to 470 rubles per pack of 56 tablets. The price of a box of 112 pieces will cost approximately 670 rubles. If you order a large package online using a photo, the purchase may be cheaper. Considering the fact that the course of treatment with De-Nol is long (up to two months), its price can be considered affordable.

How does this happen

Taking more of the drug than necessary may lead to symptoms of poisoning.

For example, dysfunction of the gastrointestinal tract may occur.

Additionally, rashes appear on the mucous membrane of the oral cavity and on the body. An inflammatory process also appears in the gastric mucosa.

But bismuth poisoning can be determined by signs such as the fact that the gums will turn black rather than red.

With prolonged overdose, renal dysfunction may occur, and these consequences may be irreparable.

Interaction of De-Nol with other drugs

The drug is not prescribed in parallel with other drugs containing bismuth (Bisal, Vikair, etc.).

The formation of a protective layer on the walls of the stomach can slow down the absorption of antibiotics from the group of tetracyclines and quinolones. The therapeutic effect of De-Nol decreases when taken simultaneously with antacids (Almagel, Phosphalugel, Maalox). A time interval of 1-2 hours should be maintained between taking the gastroprotector and other drugs.

Dosage of the drug

Depending on the age of the patient, a certain dosage is prescribed. Children are prescribed 2 tablets per day.

One tablet in the morning, second in the evening. It must be taken 30 minutes before meals.

Teenagers and adults should take no more than 4 tablets per day. At the pharmacy, De-Nol is sold in the form of blisters containing 8 tablets.

When eliminating the symptoms of gastritis, you must stop taking the drug. For some people this happens after 4 weeks, for others - after two months.

Afterwards you need to take a break for 8 weeks. During this time, you should avoid not only De-Nol, but also other drugs containing bismuth.