Pressure cord - rules of application. Drug review

Lozap. I have never suffered from problems with blood pressure. I joked that as an astronaut it’s always 120 to 80. And it was like that until I was 40 years old. But six months ago I began to experience a strong deterioration in my health due to the weather. If a cataclysm was expected in nature, headaches and heaviness in the back of the head began. It got so bad it was almost nauseating.

At first I asked my colleagues for headache pills. Then I started a permanent record of analgin at work. However, I did not consider weather-related pain to be something serious - many people experience worsening of their condition during weather changes. They even came up with a name for this ailment - weather dependence. It develops more often in those who move little and sit a lot in a stuffy room. And since I work as an accountant, the chair and the enclosed space are definitely for me.

Soon a friend noticed that my face turned red when pain appeared and suggested that I measure my blood pressure. There is no blood pressure monitor at home, there was never a need, but one of the colleagues in the neighboring department suffered from hypertension and kept the machine in her desk. When she took a measurement, it turned out that my blood pressure was 160/100.

I took the pill and went home. And the next day I made an appointment with a cardiologist. I started measuring my blood pressure every day and bought a tonometer. But neither as a result of the following measurements at work, nor when I went to the doctor, did I no longer have elevated readings. Until the next natural disaster happened.

The doctor said that as long as hypertension occurs in attacks, I don’t need to start taking serious blood pressure medications on a regular basis. It is enough to use Lozap to maintain balance, and only if the numbers rise high, take tablets in addition to this drug.

Since then I have been using the prescribed remedy. I want to say that the drug helps me a lot. Thanks to the technique, there are no longer such strong jumps.

Today I’ll tell you a little about the indications for this drug and the recommendations of doctors regarding it.

Release form and composition of "Lozap" from pressure

"Lozap" is a medicine for blood pressure with a pronounced antihypertensive effect. Belongs to a group of drugs that affect the functioning of the cardiovascular and renin-angiotensin systems, regulating the level of arterial parameters. It is used mainly in cardiology and therapy of patients of different age groups.

The drug is produced by a Slovak pharmaceutical company in tablet form. The package may contain 30, 60 or 90 tablets, packaged in blisters. In appearance, they are white, oval-shaped, film-coated tablets. Stored in a dry and dark place, at a temperature of no more than 30 °C, for 2 years. Available in pharmacy chains on a prescription basis.

The medicine lozap is a new generation of drugs with antihypertensive properties

"Lozap" is a monocomponent product based on one active substance. It includes:

• losartan potassium - active ingredient in concentrations of 12.5, 50 or 100 mg;
• magnesium stearate;
• microcrystalline cellulose;
• beckons;
• macrogol;
• titanium dioxide;
• dye
• silicon dioxide;
• povidone;
• talc.

Lozap

Doctors often say that the most dangerous human diseases are related to the functioning of the heart.
Indeed, if the “main engine” of the body begins to malfunction, then the risk of death increases significantly. I know this firsthand – I have been suffering from arterial hypertension for several years. I am saving myself with the drug Lozap. An excellent, inexpensive remedy that helps avoid complications of vascular diseases. For some reason I couldn’t find a detailed review about this drug on the Internet. Honestly, this is strange, considering that the pills help many people. I will try to leave my review and describe the effectiveness, instructions for use and side effects of the medicine.

Therapeutic effect of "Lozap" - blood pressure tablets

"Lozap" is a specific angiotensin receptor blocker. Its action is based on the regulation of physiological processes in the myocardium and systemic circulation.

A highly effective drug can be classified as a receptor suppressor for the key causative agent of arterial hypertension.

A positive therapeutic effect is achieved through several important mechanisms:

• reduction of total vascular peripheral resistance;
• a decrease in the level of adrenaline and aldosterone in the blood;
• a gradual drop in blood counts;
• normalization of pressure in the pulmonary circulation;
• preventing hypertrophy (enlargement) of the left ventricle;
• diuretic (diuretic) effect;
• increasing endurance to physical activity.

As a result, the level of diastolic and systolic pressure gradually decreases, and the risk of heart attack, stroke, and death due to heart failure is significantly reduced.

Lozap tablets are well absorbed into the bloodstream, reaching maximum concentration within an hour. The hypotensive effect is observed within 6 hours after the first dose. A lasting effect is achieved with long-term use (3-6 weeks), so the course of treatment should be prolonged.

Interaction with other drugs

Medicines can enhance or weaken the effect of the components included in Lozap.
The combination of the drug with Rifampicin and Fluconazole can cause a decrease in the concentration of the active substance in the blood plasma.

At the same time, the drug itself is able to enhance the effect of other drugs that have antihypertensive properties: ACE inhibitors, adrenergic blockers and diuretics. Lozap should be taken with caution with potassium-sparing diuretics. Otherwise, hyperkalemia may develop.

Medicines classified as NSAIDs can weaken the effect of Lozap, as a result of which after taking the tablets, the pressure may either remain elevated or decrease slightly.

Main indications

At what pressure should you take Lozap? – many hypertensive patients are interested. "Lozap" is used in antihypertensive therapy for patients suffering from high blood pressure. The main indication is essential hypertension in adults.

Lozap has a distinctive feature - it smoothly and physiologically reduces blood pressure to normal levels, prevents strokes, heart attacks and other negative factors

"Lozap" is also used to treat patients suffering from:

Therapeutic properties

Indications for the use of the drug "Lozap" are different. The drug will allow:

1. Reduce blood pressure and keep it normal.
2. Reduce the load on the heart.
3. Reduce the amount of aldosterone and adrenaline in the blood.
4. Increase tolerance to physical and emotional stress in people with cardiovascular diseases.
5. Improve cardiac circulation and renal blood flow intensity.

A moderate diuretic effect is also possible from taking the drug.

Within a few hours you can notice the first positive effect from taking the capsule. It will keep throughout the day. For a sustained reduction in blood pressure, the therapeutic course should be 1 month.

The drug is particularly effective in treating those with malignant arterial hypertension.

“Lozap Plus”, in addition to the described therapeutic actions, produces additional:

1. Helps reduce the concentration of potassium in the blood.
2. Activates the production of the hormone renin.
3. Reduces the concentration of uric acid and accelerates its elimination.

The active substances of the drugs are perfectly absorbed by the body and quickly enter the bloodstream from the gastrointestinal tract.

Method of dosing "Lozap" - a drug for blood pressure

Lozap tablets are intended for oral administration. Take once a day with a sufficient amount of plain water. Food does not affect the absorption of the drug, so the time of administration does not depend on it. It is advisable to drink the pills in the morning. Dosage depends on individual indications.

The drug is taken orally once a day

Recommended therapeutic regimen for different clinical cases:

• for hypertension – 50 mg (1 tablet) per day, if necessary, the daily dose can be increased to 100 mg;
• with reduced circulating blood volume – 25 mg per day;
• for chronic heart failure - 12.5 mg per day with a gradual increase to 50 mg;
• for diabetes mellitus – standard daily dosage of 50 mg;
• in case of liver dysfunction, the dosage is adjusted individually;
• in case of renal failure and in adulthood, no change in the treatment regimen is required.

The drug is used on a long-term basis. On average, the course of therapy is 1–1.5 months. The optimal treatment regimen is selected by the doctor based on the diagnosis and condition of the patient.

Who can the pills help?

To begin with, I will describe my personal experience with the drug Lozap. I am 38 years old, but heart problems have already appeared. At first I did not pay any attention to the unpleasant symptoms. I thought that headaches, tinnitus and blurred vision were associated with rush jobs at work, but over time I began to notice that migraine attacks often occur on vacation and depend more on weather changes than on mental stress.

This discovery scared me a little, and I went to the hospital. The doctor listened to my complaints and immediately diagnosed arterial hypertension.

For those who do not understand what I mean, I will write that by this term, specialized specialists understand a persistent increase in pressure to levels above 140 mm Hg. And this despite the fact that I lead a relatively healthy lifestyle (I don’t drink or smoke).

“Unfortunately, heart and vascular diseases are often inherited.
The fact that you don’t have bad habits is very good. This means that the risk of having a heart attack or stroke is minimal, but you should not relax. I recommend taking courses of the drug Lozap several times a year. Such preventive treatment will support overall health and eliminate unpleasant symptoms...” Elena Vasilievna, cardiologist, arrhythmologist, Novokuznetsk

By the way, looking ahead a little, I will write that there were quite a lot of such reviews from doctors. Doctors advised Lozap to people suffering not only from arterial hypertension, but also from chronic heart failure and diabetic nephropathy.

Contraindications to the drug

“Lozap” are tablets for high blood pressure; they are strictly prohibited for use in cases of hypotension (low blood pressure). Strict contraindications are also:

• individual intolerance to losartan and auxiliary components;

It is not recommended to take Lozap in the first trimester of pregnancy, and it is contraindicated in the second and third.

• severe liver pathologies;
• period of pregnancy and breastfeeding;
• childhood.

People's responses

As the great Roman playwright Terence wrote, there are so many people, so many opinions. This clever idea also applies to the drug described in this article - Lozap tablets. Reviews from patients who have used this remedy are varied. There are patients for whom this medicine did not suit: they developed a cough, tachycardia, increased sweating, etc. In this case, you cannot continue taking the pills; they should be urgently replaced with some other remedy.

But there are a considerable number of positive responses from people regarding treatment with Lozap pills. Reviews of an approving nature boil down to one thing: patients’ blood pressure decreases, the heart begins to work properly, sleep normalizes, and dizziness disappears. True, despite the fact that people speak well of these pills, they still write that they would like to not take them so often. After all, if you forget and don’t take pills for 1 day, your condition may worsen. In general, patients who have taken the drug note its excellent effect and quite reasonable price.

Possible adverse reactions

Most patients tolerate long-term drug therapy well. Undesirable effects while taking Lozap are rarely recorded, mainly due to the presence of concomitant pathologies or as a temporary reaction of addiction.

Side effects on the nervous system - anxiety, insomnia or, conversely, drowsiness, memory impairment

Most often, patients complain about:

• dizziness;
• allergic skin rashes;
• significant decrease in pressure;
• weakness and asthenic syndrome;
• dyspeptic symptoms;
• drowsiness or insomnia;
• cardiopalmus;
• cough and shortness of breath;
• migraine headaches;
• disturbance of visual and taste reactions;
• decreased libido and potency.

Long-term therapy with the drug may lead to changes in laboratory parameters (increased levels of potassium, ALT, creatinine, decreased hemoglobin). Usually, after stopping treatment, unpleasant symptoms go away on their own.

If the dosage is significantly exceeded, bradycardia, tachycardia, a sharp drop in pressure, and general signs of intoxication may be observed. In this case, symptomatic therapy and correction of the Lozap dosage regimen are carried out. The decision on the need to discontinue or replace the drug is made by the attending physician.

A number of pharmacological studies have revealed certain negative consequences from taking the drug

Special instructions for the use of the drug Lozap

Therapy with Lozap is not prescribed to patients with a deficiency of intravascular fluid volume (for example, patients receiving diuretics in high doses). If you have a history of liver disease, you should consider using the drug at a lower dose. In the presence of acute or chronic renal failure, the drug may lead to deterioration of renal function with or without hyperkalemia. Lozap should be used with caution in patients with bilateral renal artery stenosis or renal artery stenosis of a solitary kidney. Clinical studies have not revealed age-related differences regarding the effectiveness or safety of the drug. The use of the drug may negatively affect activities that require a high speed of mental and physical reactions (for example, when driving vehicles, servicing machines and mechanisms, working at heights, etc.).

Use during pregnancy and lactation

The use of angiotensin II blockers, which includes losartan, is contraindicated during pregnancy. When planning conception, it is necessary to switch to alternative treatment options with a studied safety profile. If pregnancy is diagnosed during therapy with Lozap Plus, the drug should be stopped immediately and another drug should be chosen.

Studies have shown that the use of angiotensin blockers in the second and third trimesters of pregnancy leads to toxicity to the newborn (hyperkalemia, arterial hypotension, impaired renal function), as well as to a fetotoxic effect (delayed ossification of the skull, oligohydramnios, decreased renal function). When treating Lozap plus in the second and/or third trimester, it is necessary to conduct an ultrasound examination of the skull and kidneys of the fetus.

Limited experience with the use of hydrochlorothiazide during pregnancy, especially during the first trimester, has shown that the substance can penetrate the placental barrier and into the umbilical cord blood. Hydrochlorothiazide can lead to a deterioration in fetoplacental blood flow and to pathologies in the fetus and newborn, namely: jaundice, electrolyte imbalance and thrombocytopenia.

Newborns born to women who took Lozap plus during pregnancy should be closely monitored for the occurrence of arterial hypotension.

There is no information on the use of the drug during lactation. Thiazide diuretics promote increased diuresis and a possible decrease in milk production. Hydrochlorothiazide passes into breast milk. Therefore, the use of Lozap plus during breastfeeding is prohibited. It is recommended to choose alternative medicines with an established safety profile.

Reviews

Each drug has its pros and cons. Reviews about the drug Lozap are not entirely clear. Most patients talk about the effectiveness of the drug. It quickly normalizes blood pressure, significantly improving the well-being of patients. However, the medicine does not help everyone. The following disadvantages of Lozap are noted:

• after taking a drug containing losartan potassium, patients develop a dry cough;
• the presence of tachycardia was recorded;
• there was noise in the ears;
• some types of hypertension require more than one dose;
• there were cases of lack of the required effect, which required dose adjustment or replacement of the drug;
• addiction may develop.

Drawing a conclusion about the effectiveness of the drug, it can be noted that it is not suitable for everyone. That is why the selection of an antihypertensive drug must be carried out together with the attending physician. You should not choose such medications on your own, since instead of the expected benefits, you can only cause harm to your body.

Relative and absolute contraindications

Despite the high effectiveness of the drug in the treatment of hypertension, there are a number of cases when taking Lizap is strictly prohibited, such contraindications include:

Lozap is not used in the following conditions: pregnancy

• Age up to 18 years;
• Pregnancy;
• Breastfeeding period;
• In severe renal failure due to diabetes mellitus, in which creatinine clearance is less than 60 ml per minute;
• Liver failure, obstruction of the biliary tract and other disorders in the functioning of the liver and gall bladder, since the highest concentration of the main active substance is concentrated in the liver;
• Allergic reactions or individual intolerance to medicinal raw materials.

Experts also identify a number of relative contraindications, in which the use of Lozap is allowed only under the constant strict supervision of a doctor and only when the benefits of the drug outweigh the risks of side effects.

Relative contraindications include the following violations:

• low blood pressure (hypotension);
• high levels of potassium in the blood;
• heart failure complicated by renal failure;
• ischemic disorders, characterized by insufficient blood supply to certain parts of the body and low blood volume during circulation;
• stenotic changes (narrowing) of the mitral and aortic valves of the heart;
• renal artery stenosis;
• liver diseases;
• old age (after 75).

Common features

Common features of the two medications:

• Providing a hypotensive effect.
• Suitable if ACE inhibitors do not give the desired result.
• They protect the heart and are prescribed for hypertrophied left ventricle.
• Available in one form - tablets.
• Easy to use - just take a capsule once a day to maintain normal well-being.
• Large list of side effects and contraindications.
• The presence of potassium as the active component of losartan.
• Good absorption by the body.
• Cumulative effect during treatment.
• Similar operating principle.
• Can be used from 18 years of age.
• Smooth decrease in blood pressure.
• Affordable price.
• Good reviews from doctors and patients.
• Suitable for treating elderly people.

Doctors' opinion

Alexander, 44 years old, cardiologist, Samara

Lozap is a good remedy for blood pressure control. It is well tolerated and, unlike ACE inhibitors, does not provoke a cough. Lozap plus is enhanced with a diuretic, so it lowers blood pressure more strongly and maintains it better. If the effect of a tablet taken in the morning is not enough, you should take Lozap in the evening without a diuretic supplement.

Yuri, 39 years old, general practitioner, Perm

Losartan drugs work better than members of the ACE inhibitor group and are often used as their substitutes. Lozap is weak in many cases and is not always suitable for monotherapy of hypertension. The combined drug gives a more powerful effect, but it intensively removes glucose, which is fraught with hypoglycemia and sometimes leads to anorexia.

What's better?

The medicine has many analogues or similar drugs with the same effect, including cheap analogues of Lozap. But their instructions have their differences, and only a doctor can determine what to replace Lozap with.

Losartan

When comparing the drugs Losartan and Lozap, which is better is a frequently asked question. According to the instructions for use, both medications are indicated for the correction of hypertension. They are angiotensin receptor antagonists.

Lozap and Losartan are one and the same, since the active substance of both drugs is the same. Both drugs are equally effective for arterial hypertension, but this is not a reason to thoughtlessly replace taking one with the other. Only a doctor should give appropriate recommendations.

Lorista

If we talk about medications Lozap or Lorista, which one is better, there is no significant difference. They differ only in manufacturers and cost. Lozap is more affordable, but otherwise the instructions for use are similar.

Valsartan

Before determining Valsartan or Lozap which is better, you should understand their advantages. The advantage of Valsartan is its active dosage form; it is mainly excreted unchanged through the intestines - 83%, and 13% by the kidneys. In this regard, it is often prescribed for diseases of the liver and kidneys, since it does not additionally burden these organs.

Valsacor

According to the instructions for use, the drug is intended to dilate blood vessels and arteries. This way it normalizes and maintains blood pressure. To choose Valsacor or Lozap - which is better, you need to know the differences between these drugs: Valsacor is a direct analogue of Valsartan, which means it acts on the same principle, without affecting the liver and almost without affecting the kidneys. Also, its hypotensive effect is several units higher.

Valz

Due to the more expensive price of this remedy, patients are interested in which is better: Valz or Lozap. So, Valz is an antihypertensive drug, an angiotensin II AT1 receptor blocker. According to the instructions, it has no contraindications for interaction with other drugs, and its hypotensive effect has been studied in more detail; taking the drug has a positive effect on the prognosis of the disease.

Enalapril

Antihypertensive drug, ACE inhibitor. When answering the question of which is better, Lozap or Enalapril, you need to clarify that the second drug reduces blood pressure faster and more significantly. The price of Enalapril, on the contrary, is more affordable. But it should be borne in mind that, like all ACE inhibitors, it quite often causes side cough.

Enap

This is an antihypertensive drug that, according to the instructions, reduces high blood pressure without greatly increasing the heart rate. Despite the fairly high price of Enap, doctors, when answering the question of which is better, Enap or Lozap, recommend taking the first one.

Lisinopril

This is a drug from the group of ACE inhibitors. Which is better, Lozap or Lisinopril, is a frequently asked question among patients. Both drugs for hypertension act similarly, but according to the instructions, a cough is a side effect of Lisinopril. The cost is approximately the same.

Diroton

This is a potent drug, an ACE inhibitor; according to the instructions, the duration of the effect lasts for 24 hours. The main active ingredient of Diroton is lisinopril, and the effect of both drugs is the same. That is why, in order to understand Diroton or Lozap, which is better, you need to know that doctors replace Diroton with Lozap only when intolerance to lisinopril occurs.

Prestarium

To understand which is better - Lozap or Prestarium, you need to understand their differences. Prestarium is an ACE inhibitor; according to the instructions, it is used for severe forms of hypertension, for serious disorders of the blood vessels and heart, as it reduces blood pressure smoothly. Its price is lower. But Lozap does not have a common side effect characteristic of the ACE inhibitor group - dry cough.

Noliprel

Noliprel is a combination drug. It contains 2 active components, perindopril and indapamide, which affect the body simultaneously, which is why it works more effectively.

A persistent clinical effect is observed after a month of use and is not accompanied by an increase in heart rate. In this regard, the answer to the question of which is better is obvious: Lozap or Noliprel.

Concor

It’s impossible to say for sure whether Concor or Lozap is better. They are often prescribed to be drunk simultaneously in combination. Concor is a beta-blocker that not only reduces blood pressure, but also normalizes heart rate. According to the instructions, Lozap is taken in the morning, and Concor - in the evening. The doctor selects a specific combination in accordance with the condition and individual characteristics of the patient’s body.

Equator

Equator is a combined antihypertensive drug. To answer the question Equator or Lozap - which is better, the following should be noted: compared to Equator Lozap, it has fewer contraindications according to the instructions for use.

Lozap AM

The drug Lozap AM is characterized by a stronger effect, since it contains 2 active components: losartan potassium and amlodipine. This is a more effective remedy and its use according to the instructions is indicated in difficult cases when Lozap does not help or has already caused addiction in the body.

Lozap plus

This is a combination product with a wider spectrum of coverage than Lozap. The main difference is that there are 2 active substances in the composition. Lozap plus also costs about twice as much.

What is it needed for

The medicine is used to achieve the following purposes:

• elimination of diabetic type nephropathy, which occurs against the background of the development of type 2 diabetes mellitus with high blood pressure;
• reducing the likelihood of developing cardiovascular diseases;
• elimination of chronic heart failure;
• treatment of essential hypertension.

pharmachologic effect

Lozap N is an antihypertensive drug. Its effect is based on preventing the binding of angiotensin 2 to AT1 receptors. As a result, a number of AT2 effects are leveled out:

• arterial hypertension;
• release of renin and aldosterone, vasopressin, catecholamines;
• development of left ventricular hypertrophy.

Under the influence of the drug, the angiotensin-converting enzyme is not blocked, so bradykinin does not accumulate and the kinin system is not affected.

The active metabolite Lozap is formed during biotransformation and has an antihypertensive effect on the body. Therefore, the drug is a prodrug.

The drug has the same effect on patients, regardless of their age, race and gender.

Overdose

Symptoms of a drug overdose include the following:

• pronounced decrease in blood pressure;
• tachycardia;
• bradycardia;
• dehydration and loss of electrolytes.

If the drug was taken very recently, emergency gastric lavage will help. If the case is advanced and rinsing does not help, correction of water and electrolyte disturbances is required. The active components of the drug are not so easy to remove from the body, since they cannot be removed by hemodialysis.

Pharmacokinetics

Suction

Losartan is well absorbed when taken orally, and during the “first pass” through the liver it is metabolized by carboxylation with the participation of the cytochrome CYP2C9 isoenzyme with the formation of an active metabolite.

Bioavailability of losartan (systemic) is about 33%. In the blood serum, Cmax of losartan and its active metabolite are detected after an hour and 3-4 hours after oral administration, respectively. The bioavailability of losartan is not affected by food intake.

Distribution

Binding to plasma proteins is >99%, predominantly to albumin. Vd - 34 l. Losartan almost does not penetrate the BBB.

Metabolism

Approximately 14% of losartan taken orally or intravenously is converted into an active metabolite.

Removal

The clearance of losartan (plasma) is 600 ml/min, and 50 ml/min for the active metabolite.

Renal clearance of the active ingredient and its active metabolite is 74 ml/min and 26 ml/min, respectively. About 4% of the oral dose is excreted unchanged through the kidneys and about 6% through the kidneys in the form of an active metabolite.

Losartan and its active metabolite are characterized by linear pharmacokinetics when administered orally in doses up to 200 mg. Concentrations of losartan (plasma) and its active metabolite from the moment of oral administration decrease polyexponentially, with the final half-life of losartan being 2 hours and its immediate active metabolite being 6-9 hours.

In plasma, neither losartan nor the active metabolite practically accumulates at a dose of 100 mg/day Lozapa. Losartan and its metabolites are eliminated from the body through the intestines and kidneys.

Pharmacokinetics in certain cases

The concentration of losartan in moderate and mild alcoholic cirrhosis of the liver was 5 times higher, and the active metabolite was 1.7 times higher, compared with healthy male volunteers. In blood plasma, the concentration of losartan with CC >10 ml/min is identical to that with normal renal function. The AUC is twice as high in individuals requiring hemodialysis than in individuals with normal renal function.

Neither losartan nor carboxylic acid (E-3174), which is its main active metabolite, is removed from the body during hemodialysis.

In the blood plasma, the concentrations of losartan and its immediate active metabolite in men with hypertension, both elderly and young, do not differ significantly.

Plasma concentrations of losartan in women with hypertension are twice as high as in men with hypertension.

Concentrations of the active metabolite do not differ between men and women.

What to replace if Lozap does not hold pressure?

How to replace Lozap if it does not hold pressure is a common question when the product ceases to perform its functions. Specialists replace it with other medications with the same indications according to the instructions for use.

This often happens because hypertension constantly progresses and medications become ineffective over time. There are three tactics to solve this problem:

• increasing the dose;
• prescribing combination therapy, that is, adding additional medications;
• replacement of the product used.

A list of them is given above. In accordance with the individual course of the patient’s disease and the instructions for the medicine, the doctor chooses treatment tactics and carefully monitors its effectiveness in a particular situation.

Compound

One tablet contains two active ingredients:

• Losartan potassium (50 mg). This is an angiotensin II hormone receptor blocker (AT1 subtype). It does not inhibit kinase II, an enzyme that breaks down bradykinin. The blocker reduces peripheral vascular resistance, afterload, aldosterone and adrenaline levels. Prevents the development of myocardial hypertrophy. Helps patients with heart failure increase exercise tolerance. Losartan is absorbed into the blood from the intestinal tract and is broken down in the liver, releasing an active metabolite. It reacts with blood plasma protein. The maximum concentration of the substance in the blood is observed 60 minutes after administration. Metabolism occurs within 3-4 hours. The component is excreted after 2 hours: with urine – 34%, and from the intestines – 66%.
• Hydrochlorothiazide (12.5 mg). This is a thiazide diuretic that reduces sodium absorption. Helps remove potassium, phosphate and bicarbonate from the body unchanged in the urine for 6-14 hours after taking the drug. Helps lower blood pressure because it changes the reactivity of vessel walls, reduces the volume of circulating blood and increases depressor pressure. The component dissolves in the stomach and enters the blood, slowing down the removal of potassium ions from the body. Almost 61% of the substance is excreted unchanged by the kidneys.

The excipients are:

• microcrystalline cellulose (MCC) (210 mg);
• mannitol (89 mg);
• povidone (7 mg);
• magnesium stearate (3.5 mg);
• croscarmellose sodium (18 mg).

Shell composition:

• hypromellose 2910/5 (6.8597 mg);
• macrogol 6000 (0.8 mg);
• talc (1.9 mg);
• simethicone emulsion (0.3 mg);
• titanium dioxide (0.1288 mg);
• quinoline yellow dye (E104) (0.011 mg);
• crimson dye (E124) (0.0005 mg).

Approximate price in Russia

Depending on the size of the Lozap package, its dosage, as well as the manufacturer, its price can vary between 230-300 rubles per pack. Cheaper analogues should only be selected together with a doctor.

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Still have questions? Ask them in the comments! Cardiologist Mariam Harutyunyan will answer them.

Ivan Grekhov

Graduated from the Ural State Medical University with a degree in General Medicine. General practitioner

Analogs

If necessary, you can replace the product with analogues. Such medications include:

1. Lorista is a drug with antihypertensive effects.
2. Enap is a medicine containing enalapril. Helps lower blood pressure.
3. Indapamide is a medicine in which the active substance is indapamide hemihydrate. Refers to antihypertensive and diuretic medications.
4. Micardis is a drug aimed at suppressing angiotensin 2 receptors, which leads to vasodilation and normalization of blood pressure.
5. Telmisartan is a drug with the same active ingredient. The medicine is used during the treatment of arterial hypertension.
6. Candesartan is a drug produced in Russia and Switzerland.
7. Lozap Plus is a product containing losartan. Additionally, it contains hydrochlorothiazide, a substance with a diuretic effect.

Losartan

It is a receptor blocker for a substance in the body that provokes an increase in blood pressure and the release of a kidney hormone, which in excess affects an increase in blood pressure.

The medicine has a preventive vasoconstrictor effect. It “works” in the body for 24 hours, its high efficiency is due to the formation of its active metabolite.

By reducing aldosterone in the blood, which controls electrolyte balance, it has a protective effect on the kidneys in people with type 2 diabetes. Helps remove sodium and water from the body, preventing their retention.

Main effects in the body:

1. Blocks angiotensin 2 receptors in the kidneys, brain, liver, blood vessels and heart.
2. Reduces pressure in peripheral vessels and the aorta.
3. Prevents myocardial hypertrophy.
4. Improves physical endurance in patients with heart failure
5. Does not block ion channels important for heart function.
6. Does not change heart rate.