The drug "Odeston": indications for use, instructions, composition, analogues, reviews

Gallbladder diseases are not uncommon these days. A huge number of people hear diagnoses of “cholecystitis” and “biliary dyskinesia” addressed to them. The causes of these diseases may be different, but treatment for such ailments should be aimed at strengthening and timely removal of bile. It is for these purposes that doctors very often prescribe the drug "Odeston", reviews of which show that the drug copes with these tasks really well, but independent use of this drug is unacceptable. Only a doctor who will monitor the patient’s condition throughout the course of treatment has the right to prescribe such therapy.

The effect of the drug "Odeston"

Reviews from doctors about this choleretic drug indicate that the active component of the medication helps reduce bile stagnation, enhances its formation and ensures excretion. In addition, the effect of the drug is aimed at preventing the crystallization of cholesterol. The drug also has an antispasmodic effect on the bile ducts. The composition of the drug does not reduce blood pressure and, which is quite important for such diseases, does not affect intestinal motility. When tablets are taken orally, the drug is well absorbed from the gastrointestinal tract, the maximum concentration of the active component is observed in the blood serum 2-3 hours after administration. The medicine is excreted through the kidneys in the form of glucoronate - 93%, sulfonate - 1.4%, and unchanged only 0.3% of a single dose.

Why is Odeston prescribed?

It is recommended to take the medicine for the following pathologies:

1. Dyskinesia of the sphincter of Oddi and bile ducts, leading to congestion.
2. Chronic non-calculous cholecystitis is inflammation of the gallbladder without the presence of stones.
3. Cholelithiasis, cholangitis.
4. Decreased appetite, nausea and vomiting caused by hypersecretion of bile.

Prescribed after surgical interventions, for example, after removal of the gallbladder, and during the recovery period.

Doctors often recommend taking medicine for gastritis, which is accompanied by weakness of the sphincter of Oddi. In this case, a large amount of bile is thrown into the stomach, which irritates the walls of the organ, provoking an attack of the disease.

For hemorrhoids

The instructions for use do not mention the possibility of use for this disease. However, stagnation of bile has a direct impact on the digestive process.

As a result of reduced functionality of the gastrointestinal tract, a person often develops chronic constipation, which becomes a provocateur of hemorrhoids. Therefore, the medicine is often prescribed as an additional therapy if the disease occurs against the background of pathologies of the gallbladder and ducts.

For hemorrhoids, the medicine is prescribed as an additional therapy if the disease occurs against the background of pathologies of the gallbladder and ducts.

For pancreatitis

Inflammation of the pancreas is often accompanied by pathologies of the liver, bile ducts, and bladder. Often, bile stagnation or cholecystitis is diagnosed simultaneously with pancreatitis.

Composition of the drug, release form and cost

One Odeston tablet, which has a flat-cylindrical shape with a chamfer on one side and engraved Ch on the other and can be white or yellowish in color, includes 200 mg of the active component hymecromone and excipients such as potato starch, gelatin, texapone K12 and magnesium stearate. The tablet form of the drug is available both in a blister and in bottles in both forms of 50 pcs. The cost of the drug, depending on the pharmacy chain and packaging, ranges from 308 to 480 rubles.

The most popular analogues

When choosing a substitute for Odeston, you need to consult a doctor. There are many choleretic agents on the pharmaceutical market, differing both in composition and mechanism of action. However, there is no complete analogue of Odeston, which would have hymecromone as an active substance. That is why you cannot do without the help of a doctor. The doctor must choose the most appropriate drug, taking into account:

• type of disease;
• severity of symptoms;
• the presence of concomitant pathologies;
• age and characteristics of the patient’s body.

In what cases is it prescribed

As a rule, this drug is sold in pharmacies without a prescription, but independent use is highly undesirable. It is the doctor who can prescribe the necessary examinations to the patient, which will confirm or refute this or that diagnosis for which the drug Odeston is prescribed. Reviews about this medication confirm the fact that treatment is effective only when recommended by a qualified specialist. The drug is prescribed for the following diagnoses:

• biliary dyskinesia;
• dyskinesia of the sphincter of Oddi of the hyperkinetic type;
• as therapy after surgical treatment of the biliary tract and gallbladder;
• nausea, vomiting, constipation and loss of appetite resulting from bile hyposecretion.

Advantages and disadvantages

When choosing what is best, you need to proceed from the specific situation and age category of the patient. Odeston has a selective antispasmodic effect on the sphincter of Oddi and the sphincter of the neck of the gallbladder. At the same time, while removing the “barrier” to the movement of bile into the intestines, it does not stimulate the contractile function of the bladder itself. The opponent simply acts by stimulating the contractions of the gallbladder, while not having antispasmodic activity, and therefore should be prescribed as part of complex therapy. If a child needs a choleretic drug, then the choice is Allochol or another drug prescribed by the doctor, because Odeston is only allowed for adults.

Differences in contraindications and costs

Contraindications

The cost of Allochol is low, 50 tablets cost approximately 50 rubles (may vary depending on numerous manufacturers). A package of Odeston with the same number of tablets will cost almost an order of magnitude more - around 500 rubles.

Cases in which the drug is prohibited

Like all medicines, Odeston also has contraindications. Instructions for use, reviews of which say that the list of side effects from using this medication has a fairly impressive number of items, and indeed has a lot of contraindications. Among them, individual intolerance to the constituent components, the period of pregnancy and lactation are primarily noted. In pediatrics, the use of the drug “Odeston” is also unacceptable, reviews of which indicate that it is very difficult to tolerate, and an immature body is not able to withstand such a drug load. This list also contains a list of ailments for which the use of the drug is strictly prohibited:

• obstruction of the biliary tract;
• liver and kidney failure;
• hemophilia;
• ulcer of the duodenum and stomach;
• Crohn's disease;
• ulcerative colitis.

Contraindications

The medication is not suitable for treatment in the following cases:

1. Due to hypersensitivity to the ingredients of the drug that are part of it.
2. The presence of obstruction of the bile ducts.
3. Kidney or liver failure, as well as ulcerative colitis.
4. The presence of Crohn's disease or ulcerative pathology of the digestive system.
5. The presence of hemophilia in the patient, as well as childhood under eighteen.

Contraindications for Odeston must be strictly observed. There is no data on the safe use of this pharmaceutical during pregnancy and lactation. The use of the medicine during this period is allowed only in situations where the benefit to the woman outweighs the possible risk to her child.

Side effects of the drug

Almost every drug of chemical origin has side effects, and Odeston is no exception. Reviews from patients indicate that when taking these pills, undesirable consequences may occur, which once again confirm that it is unsafe to self-medicate, since the consequences of such therapy can be very serious. When using this medication, you may develop diarrhea with its inherent flatulence and cramping, ulceration of the mucous membrane of the digestive organs or other places where ulcers form, abdominal pain or (as they are also called) “hunger” pain of a constant nature, as well as allergic skin rashes and sudden headache attacks pain. All these symptoms can appear either individually or all together.

pharmachologic effect

The drug has the international name "Gimecromon", although it is not patented. This drug increases the production of bile and facilitates its outflow from the liver. Further removal is ensured due to the fact that the drug in question perfectly relieves spasms, which allows it to be used effectively for hyperkinetic dyskinesia of the bile ducts.

Not everyone knows why Odeston is prescribed. The action of the described medicine also makes it possible to relieve spasms of the common bile duct. This remedy has a relaxing effect on the entire biliary system, its smooth muscles and the sphincter of Oddi. Thanks to its therapeutic effect, bile does not encounter any obstacles on its way from the liver, just as it does not encounter any obstacles during its further movement into the intestines.

Hypermotor dyskinesia manifests itself as periodic pain of varying intensity in the area of ​​the right hypochondrium. Sometimes the manifestations are not very strong, but are permanent, causing severe discomfort in the patient. Such an unpleasant symptom occurs when there are spasms of the bladder or biliary tract system, and the use of Odeston allows you to eliminate them and eliminate pain.

In addition, this drug can have a similar effect on the pancreatic ducts, as a result of which the secretion produced by it freely penetrates the intestines.

This is very important for the proper functioning of the digestive system, because stagnation of biomaterial in this internal organ can provoke acute pancreatitis, as a result of which its tissues begin to be digested, which in turn is accompanied by a very severe pain syndrome, which can be relieved by this medication

Rules for taking the drug

For treatment to be effective, you should follow all recommendations regarding the use of Odeston. Indications for use, reviews of taking this medicine say that when taking the drug, special attention should be paid to the time interval between taking these tablets. This rule is very important to follow in order not to exceed the concentration of the active substance in the body, which can lead to an overdose, increasing the side effects of the drug. As a rule, the daily dose, the maximum amount of which can be 1200 mg, is divided into 3 doses. The tablet should be taken half an hour before meals, and should not be washed down with hot tea or coffee. Only water is suitable for this purpose. One dose, depending on the patient’s condition, can contain from 200 to 400 mg of the drug. On average, the duration of treatment is about two weeks. However, the doctor may prescribe another regimen for taking the drug for a longer period.

Indications for use of the drug "Odeston"

This pharmaceutical drug is prescribed to patients if they suffer from the following conditions and diseases:

1. Development of dyskinesia of the bile ducts and sphincter.
2. The presence of non-calculous chronic cholecystitis, cholangitis, cholelithiasis. What else is Odeston prescribed for?
3. Conditions after surgical interventions on the gallbladder and its ducts.
4. If a person experiences a decrease in appetite along with vomiting, nausea, constipation due to bile hyposecretion, and so on.

Indications for use of the drug "Odeston" are described in detail in the instructions.

special instructions

Regarding driving vehicles and working in enterprises associated with hazardous activities where increased concentration of attention is required, when taking the drug "Odeston", reviews and instructions warn that the active component of the drug does not affect psychomotor reactions in any way.

This drug does not require special storage conditions, however, standard recommendations for humidity and temperature up to 25 degrees should not be neglected. If the conditions are met, the medicine can be stored for 3 years.

Interaction with other drugs

Due to the fact that morphine promotes the formation of spasms of the sphincter of Oddi, its simultaneous use with Odeston leads to a weakening of the antispasmodic effect of the latter.

The drug enhances the activity and therapeutic effectiveness of indirect anticoagulants.

The combination of Odeston with metoclopramide or its derivatives leads to a mutual weakening of drug effectiveness.

Odeston enhances the effects of indirect anticoagulants. Morphine weakens the effect of hymecromone. When taken together with metoclopramide, a weakening of the effect of both drugs is observed. Odeston is produced in Poland and is available without a prescription. The medicine does not reduce the ability to concentrate and does not affect the speed of psychomotor reactions.

Morphine weakens the effect of hymecromone.

When taken together with metoclopramide, the effect of both drugs is weakened.

Enhances the effects of indirect anticoagulants.

Morphine and its analogues reduce the effectiveness of the drug. Some antiemetics in combination with medications tend to mutually weaken the effect. The product also increases the effectiveness of some anticoagulants.

Alcohol and medicine "Odeston"

Instructions, reviews, price of the drug - this is quite important information for the patient, but it is also worth paying attention to those issues that are often not discussed, which are taken for granted. But nevertheless, many do not take it into account, which leads to a deterioration in the patient’s condition. We are talking about drinking alcohol during therapy. Experts note that drinking alcohol with any type of medication is extremely undesirable. Since alcohol is processed directly by the liver, which is already under stress from illness and from the effects of medication, the addition of alcohols can cause a lot of undesirable and even threatening consequences. Therefore, you should not take such risks when taking this medication. And the absence of this item in the special instructions in the instructions for the drug does not mean at all that such a combination is welcome. You can purchase the medicine “Odeston” for an average of 420-450 rubles, but in some cases prices can range from 375 to 505 rubles.

Diseases of the gallbladder and liver affect the digestion process and metabolism. The pharmaceutical market offers a variety of drugs to treat diseases. One of the original drugs used in hepatology and gastroenterology is Odeston, a choleretic medicine in tablet form.

Vacation conditions and price

The cost of Odeston is on average 561 rubles. Prices range from 301 to 1160 rubles.

The price of medicines largely depends on the region and pharmacy chain, as well as on the manufacturer. Thus, Odeston in Russia can be purchased in the range from 250 to 450 rubles, and in Ukraine the price will be higher and can reach up to 250 hryvnia.

The average price of ODESTON in pharmacies (Moscow) is 335 rubles.

The average cost of Odeston (200 mg tablets No. 20) in Moscow is 415 rubles. Available without a prescription.

Store out of reach of children at temperatures up to 25 C. Shelf life – 3 years.

Instructions for use of tablets 200 mg

Odeston combines choleretic and selective antispasmodic effects, which is why in many cases it is the drug of choice.

Compound

Gimecromone is the active substance, the concentration in one Odeston tablet is 200 mg.

Additional components of the composition:

• starch;
• gelatin;
• sodium lauryl sulfate;
• Magnesium stearate.

Yellow-white tablets with a score line, engraved “Ch” on one side.

Packaging No. 20, 50 or 100 pcs. Available without a prescription.

Manufacturer

The drug is produced at the Pabyanitsky pharmaceutical plant. The Odeston manufacturer is located in Poland.

What is it prescribed for?

Gimecromone belongs to the pharmaceutical group of choleretic drugs that relieve spasm of the bile outflow tract, sphincter of Oddi. Thus, the excretion of bile secretion improves, stagnation and the formation of stones are prevented, digestion is stabilized, for which Odeston is prescribed.

Composition and description

One Odeston tablet contains:

• hymecromone 200 mg – active ingredient;
• potato starch, gelatin, sodium lauryl sulfate, magnesium stearate – excipients.

Odeston tablets are round, white to white with a yellowish tint, flat-cylindrical, chamfered and engraved on one side with the letters “Ch”.

The drug is produced in the form of tablets. Packaged in packs of up to 50 pieces. The active ingredient is hymecromone (200 mg in one tablet). Excipients include gelatin, potato starch, magnesium stearate and lauryl sulfate.

Review Reviews

On average, 9 out of 10 taking the medicine note good tolerability and a rapid decrease in symptoms in the form of nausea, bitterness in the mouth, and discomfort in the right hypochondrium.

Some patients report a strong feeling of hunger after taking the pill, leading to overeating.

There are reviews of Odeston indicating the appearance of diarrhea and headache after taking the drug.

Rarely, a two-week course is not enough for the complete disappearance of symptoms; more often this is due to a violation of the diet and diet.

Pharmacodynamics and pharmacokinetics

Odeston has a choleretic effect, increasing the formation and secretion of bile fluid.
It also exhibits a selective effect on the elements of the fibers of the biliary and excretory sphincter. At the same time, there is no decrease in blood pressure and contractile function of the gastrointestinal system. When taking the medicine orally, the active substance is absorbed quite effectively from the digestive tract and does not come into sufficiently strong contact with serum proteins. The maximum concentration of the main component of the drug in the blood plasma is reached after two to three hours. The half-life is approximately 1 hour. Hymecromone is eliminated through the urinary system.

Side effects

The list of side effects of the drug is small.

Side effects encountered while taking Odeston:

• individual allergic reactions to drug components;
• pain and discomfort in the abdomen;
• increased gas formation, increased intestinal motility;
• loose stools;
• headache;
• formation of defects in the mucous membrane of the gastrointestinal tract in the form of ulcers.

Side effects

Allergic reactions, ulceration of the mucous membrane of the digestive tract, diarrhea, flatulence, abdominal pain of various types, headache.

Manifestations of individual intolerance and hypersensitivity to substances in Odeston, according to reviews, are the following symptoms:

1. From the digestive system: bloating, diarrhea, vomiting, cramps, increased flatulence, abdominal pain and bloating.
2. Allergic reactions: hives, rash, etc.
3. From the central nervous system: insomnia, headaches, irritability, etc.

If you notice the development of these symptoms while taking it, you should stop the drug and consult a specialist. In most cases, reducing the dosage of the drug helps get rid of side effects.

Analogs and which one is better

Among the drugs, a distinction is made between drugs with a direct choleretic effect and drugs whose effect on the production of bile and its excretion is additional. Odeston analogues in tablets may have additional properties, which determines the subtleties of their purpose.

Allohol

Choleretic drug of animal and plant origin. Allochol is multi-component: cattle bile, activated carbon, garlic, nettle leaf. Garlic enhances peristalsis of the gastrointestinal tract. Nettle has anti-inflammatory and choleretic effects.

Odeston, compared to Allochol, has a more pronounced choleretic effect, which is better for active forms of the disease. In addition, when treating with hymecromone, the use of additional antispasmodics is not required.

Hofitol

A herbal preparation based on field artichoke leaves.

When using Odeston or Hofitol, the functioning of the biliary tract is stabilized, which is better for the functioning of the entire digestive tract. The choleretic effect of hymecromone is higher.

Hofitol, in addition to being a choleretic agent, has hepatoprotective properties, a diuretic effect, and enhances the excretion of urea.

Ursosan

The medicine lowers blood cholesterol levels and has immunomodulatory activity. In many cases, when choosing between Ursosan or Odeston, preference is given to the first drug, as it is complex, more effective, and has a hepatoprotective effect.

Ursofalk

The active substance is ursodeoxycholic acid, also a hepatoprotector with a choleretic effect. Indications for treatment are the same as for Ursosan. When choosing which is better - Odeston or Ursofalk, as a rule, preference is given to the second drug as more effective, although this largely depends on the diagnosis.

Duspatalin

The active ingredient is mebeverine, relieves gastrointestinal spasms and normalizes peristalsis. The drug is a symptomatic remedy used for irritable bowel syndrome, approved for long-term use.

Duspatalin or Odeston have antispasmodic activity, which is better expressed in mebeverine.

Gepabene

A choleretic preparation based on extracts of fume and milk thistle leaves, which has hepatoprotective, antioxidant and membrane-stabilizing effects. Odeston or Gepabene are indicated to relieve symptoms of dyspepsia, while the choleretic effect of gimecromone is higher, which is better detected during administration.

Analogs

The range of analogues of the drug in question (choleretic drugs) is currently represented quite widely on the Russian pharmaceutical market. Each product has certain properties, including indications, contraindications and side effects. Analogs of "Odeston" that enhance bile secretion are divided into the following groups:

1. Medicines that are made on the basis of bile acids. They are also called true choleretics.
2. Medicines of chemical synthesis.
3. Herbal remedies.

Bile secretion can be increased due to the water component that hydrocholeretics have. Accordingly, mineral water, sodium salicylate, and valerian-based preparations should be considered substitutes for Odeston.

Choleretic medicines of animal nature contain natural bile or an oxidation product in the form of dehydrocholic acid. Among them it is worth mentioning “Hologon” along with “Allohol” and “Holenzim”.

Synthetic choleretics favor significant production of bile secretions, surpassing acid salts in their activity. It is worth noting that all such drugs are low-toxic. Pharmaceuticals in this group include medications in the form of Nicodine, Oxafenamide and Cyclone.

Alcohol compatibility

The official instructions for the drug do not contain data on the compatibility of Odeston and alcohol. Since alcohol increases the excretion of bile, therefore, combined use with alcohol is not recommended.

Odeston : 6 reviews from doctors, 2 reviews from patients, instructions for use, analogues, infographics, 1 release form.

Synonyms of nosological groups

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Reviews from doctors about odeston

The drug has a choleretic and antispasmodic effect, can be prescribed for biliary dyskinesia, cholecystitis, postcholecystectomy with pain syndrome, the course of treatment is not burdensome, and has virtually no side effects.

The drug is not cheap.

A drug with a real positive effect!

“Odeston” has proven itself well in gastroenterology for chronic cholecystitis, it has antispasmodic and choleretic effects in cases of biliary system disorders. The duration of the course is three months, twice a year, depending on the stage of the disease.

The price is high, the quality is good.

It must be taken in combination with Ursofalk, the effect is softer and more correct. Side effects are possible; consultation with a specialist is necessary.

The drug is effective for problems of the biliary system.

I don’t recommend it on my own, because... I generally don’t take part in recommendations.

No side problems were identified. The drug is used as a choleretic and antispasmodic. Often recommended by gastroenterologists.

The drug promotes contraction of the gallbladder while simultaneously effectively relaxing the sphincters. A good effect where choleretic therapy is indicated. Epigastric pain may occur with concomitant duodenogastric reflux.

Experience in using the drug in the presence of stones larger than 1 cm with a positive result.

The drug works well for problems of the biliary system.

The price tag for the drug could have been lower.

The drug has two actions, as a choleretic and an antispasmodic. It is excellent to use for disorders of the biliary system accompanied by pain. Approved for use in pediatrics. I did not observe any side effects.

The drug "Odeston" is indispensable in the treatment of patients with dysfunction of the sphincter of Oddi after cholecystectomy. In addition, hymecromone has a positive effect on gallbladder dysfunction with hypomotor function of the bladder and spasm of the sphincter of Oddi.

In the last message at the gastroweek in Moscow, recommendations were given for taking Odeston even in the presence of stones in the gall bladder, which was not previously recommended.

Allohol and Odeston - what's the difference?

Allohol is a complex product based on products of animal and plant origin, containing:

• dry bile - 0.080 g;
• garlic extract - 0.040 g;
• nettle extract - 0.040 g;
• activated carbon - 0.025 g.

According to the manufacturers, Allochol normalizes bile formation by stimulating the gallbladder and improving liver function, and reduces the likelihood of the formation of calculi (stones) in the cavity of the gallbladder. Under the influence of Allochol, intestinal motor activity is also weakly stimulated, due to which fermentation processes are inhibited, and, therefore, the frequency of constipation and gas formation is reduced. However, you will not find the results of serious clinical studies confirming all these beneficial properties. Garlic may have a slight choleretic effect, but “reducing the likelihood of stone formation” is unlikely.

The drug is available in the form of film-coated tablets, packaged in packs of 10, 24 or 50 pieces. Country of origin: Russia (Dalkhimpharm, Vifitech and others) or Belarus (Belmedpreparaty).

50 tab.

The difference between Odeston is that it is a synthetic drug containing hymecromone

. Its amount in one tablet is 0.2 g.

This compound activates the production of bile and promotes its release into the intestines. This mechanism of action is explained by the fact that the substance selectively eliminates spasm from the sphincter of Oddi and smooth muscle tissue of the biliary tract. Odeston does not affect the peristalsis of vascular walls. Hymecromone eliminates cholestasis (stagnation of bile) and increases its quantity, and the concentration of bile acids and cholesterol in it increases, which improves the breakdown of the fatty fraction of foods.

The drug is produced in the form of white flat-cylindrical tablets, packaged in boxes of 20 or 50 pieces. Country of origin: Poland, .

50 tab. (200 mg)

There is also a difference regarding the use depending on the meal. Odeston is taken half an hour before meals so that its antispasmodic effect has time to work. Allochol, on the contrary, should be taken immediately after meals, as it contains ready-made bile, which helps in digestion.

Both are used for the following conditions:

1. Biliary dyskinesia.
2. Cholecystitis, as well as cholangitis in the chronic stage.
3. Condition after surgical manipulation of the gallbladder or bile ducts.
4. Constipation, nausea, loss of appetite due to decreased bile production.

Allochol can be prescribed to children under seven years of age in a reduced amount (the dosage is determined by the doctor), and starting from the age of seven in a dosage for adults. Women during pregnancy can also use it as prescribed by a doctor, but, of course, this drug should not be abused.

Patient reviews about odeston

I found out about this medicine when I was admitted to the hospital with terrible pain in the abdomen. I have had problems with my pancreas since childhood. So, I ended up in the hospital, they kept me there for three days, they did an ultrasound, tests, pierced me, gave me eye drops and kept me on water, but at the same time they said that everything was fine. And then, after the operation, a girl of about 15 was brought in, her gall bladder was removed, and she said that “Odeston” helped her as long as it was possible! I waited until the evening for the doctors to tell me, and oops - everything is fine again. I wrote a refusal and left. I went to the pharmacy and bought Odeston! In fact, it helped a lot, now when pain occurs, I drink it.

For pain in the right side and constant nausea, a diagnosis of biliary dyskinesia was made, and the gastroenterologist prescribed Odeston. After the first dose, the pain went away. I took it for 21 days and felt great. When the course was completed, after 2-3 days the pain reappeared. Repeated again for 2 weeks. It happened again with Fr. After completing the course, everything returned to normal.

Pharmacological group

The medicinal drug Odeston belongs to the group of choleretic drugs that have a selective (selective) antispasmodic effect. The active substance of the drug, represented by hymecromone, is a coumarin derivative.

Against the background of the influence of the active element of the drug, there is an increase in the synthesis and evacuation of bile into the intestinal lumen. Stimulation of the rate of bile synthesis is created due to the selective relief of spasm from the smooth muscles of the bile ducts and the sphincter of Oddi.

Also, the medicine Odeston does not allow cholesterol to crystallize and helps eliminate cholestasis. Under the influence of hymecromone, the degree of activity of the lipase enzyme increases, which makes it possible to create conditions for complete emulsification and resorption of lipids.

The drug Odeston does not have a direct effect on the tone of the smooth muscles of the vascular walls and intestinal motility.

The drug is easily absorbed from the gastrointestinal tract after oral administration. The degree of binding to serum proteins is weak. Maximum plasma concentrations are achieved on average 2–3 hours after oral administration.

The half-life ranges from 30 to 60 minutes. Approximately 93% of the substance is excreted by the kidneys in the form of glucoronate. The rest of the substance is excreted in the form of sulfonate (1.4%) and unchanged (0.3%).

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Signs of pathology

Symptoms of gallbladder diseases are quite similar, regardless of the cause of occurrence, the nature of the pathology and the pattern of development. The main sign of problems in this organ is constant aching pain in the area of ​​the right hypochondrium. The pain syndrome is not relieved by painkillers and, as a rule, appears after fried, fatty or spicy foods. If a stone comes out of the gallbladder, the pain takes on a cutting, sharp form. This process is also characterized by:

1. Increased body temperature.
2. Nausea, belching, vomiting and other signs of dyspepsia.
3. Constipation, diarrhea and other intestinal disorders.
4. Increased flatulence and bloating.
5. Loss of appetite and unreasonable weight loss.
6. Dry mouth and bitter feeling.
7. Rash on the body, accompanied by itching.
8. Yellowing of the skin.
9. The color of the urine becomes intensely yellow, and the feces may become discolored.
10. Irritability and insomnia.

Jaundice syndrome on the skin and sclera of the eyes is an obvious sign of a pathological process in the liver. In this case, there is a high risk of complications such as cirrhosis, liver failure, bleeding of internal organs, etc.

Reviews

Reviews about Odeston are mostly positive. The symptoms of the disease and its severity were relieved by taking the drug and following a special diet. Experts prescribe it to those who have reduced immunity during the postoperative period. This helps restore patients' appetite and normalize the digestion process. Many reviews note that the feeling of bitterness and dryness in the mouth, heaviness and bloating quickly disappeared. Some patients prefer to use it prophylactically to avoid the return of the treated disease.

There are, however, also negative reviews. Among them are complaints that the drug is prohibited from taking during pregnancy and lactation. Several reviews mention the overpriced. There is also information about cases where the drug had no effect or caused severe side effects.

In general, if you focus on the reviews, you can conclude that the drug is quite effective. It is advisable to prescribe it for pathologies of the gallbladder, and in the vast majority of cases the therapy will give a positive result.

We reviewed the instructions for Odeston, reviews and analogues.

Choleretic drugs are a specific group of medications, without which people with bile duct diseases cannot imagine a normal life. Odeston is one of the most famous representatives of his group. The drug acts quickly and very effectively. But despite its many advantages, the medication is not suitable for everyone. Fortunately, there are quite a lot of analogues of Odeston, so everyone can choose the most effective and suitable medicine for themselves.

What is better - Hofitol, Ursosan, Allohol or Odeston?

All these drugs are well-known choleretic agents, which are simply crazy popular in certain circles. Each medication has its own characteristics, so before choosing a truly effective replacement for Odeston, you will have to consult a specialist.

Odeston is an excellent choleretic agent. In addition to increasing the formation and secretion of bile, the medication can have a selective antispasmodic effect on the sphincter of Oddi and bile ducts. The active components of Odeston prevent the deposition of cholesterol crystals, but do not reduce the motility of the gastrointestinal tract and do not in any way affect blood pressure.

The main difference between one of the most popular analogues of Odeston Allochol tablets is its composition. The main active ingredient in Odeston is hymecromone. Allochol contains activated carbon, nettle leaves, garlic, and bile.

As practice has shown, Ursosan and Odeston are best taken in parallel - the drugs complement each other remarkably. And Hofitol can be a very useful substitute for Odeston during the period of prophylaxis.

Indications for the use of all the drugs described above and their other analogues are approximately the same:

• biliary dyskinesia;
• problems associated with decreased bile secretion (frequent constipation, nausea, vomiting);
• chronic forms of cholangitis and cholecystitis;
• lack of appetite;
• simple form of cholelithiasis;
• dyspepsia;
• chronic hepatitis.

Many experts prescribe Odeston and its analogues to restore the body after operations on the gallbladder and biliary tract.

Odeston price, where to buy

In pharmacies in Moscow and Russian regions, the price of Odeston, a package of 50 tablets, varies from 390 to 490 rubles.

In Ukraine, Odeston can be purchased at a price of 209-259 UAH.

• Online pharmacies in RussiaRussia
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• Odeston tab. 200mg n20Polfa Pabianice
• Odeston tab. 200mg n50Polfa Pabianice
• Odeston tab. 200mg n100Polfa Pabianice

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• Odeston (200 mg tablet No. 20)
• Odeston tablets 200 mg No. 50
• Odeston tablets 200 mg No. 100

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• Odeston 200 mg n50 tablet Pabyanitsky pharmaceutical plant Polfa
• Odeston 200 mg No. 20 tabPabyanits.f.z. Polfa

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Odeston's analogues

The drug has no analogues, the price and composition of which do not differ from the original. Each drug has its own characteristics, so replacing Odeston with another drug on your own without consulting a specialist is not recommended.

The price of Odeston in a dosage of 200 mg in Moscow starts from 415 rubles, and in St. Petersburg - from 522 rubles. The cost of the drug in the regions depends on the manufacturer and pharmacy.

List of drug analogues:

1. Hepel.
2. Allohol.
3. Ursosan.
4. Cynarix.
5. Glutargin.
6. Artichol.
7. Riabal.
8. Gepabene.
9. Olimethine.
10. Bonjigar.
11. Papaverine.
12. Holagol.
13. No-Shpa.
14. Holosas.
15. Febichol.
16. Tanacehol.
17. Hepaphytol.
18. Holenzim.
19. Holiver.
20. Hofitol.

Side effects

The list of negative effects after using the medicine is quite extensive. But it is worth noting that with a correctly formed course of treatment, any side effects on the body are practically eliminated. The most common side effects are:

1. Hypersensitivity reactions.
2. Digestive system disorders.
3. Bloating.
4. Pain in the abdominal cavity.
5. Formation of ulcerative defects on the mucous membrane.
6. Migraine.

Abdominal pain is one of the undesirable consequences.
Skin itching often occurs during the use of the drug. Urticaria may occur as a result of taking the medication.

Method and features of use

The medication is intended for the treatment of gallbladder diseases. The use of Odeston is necessary if the patient has the following objective medical indications:

• violation of peristalsis of the gallbladder canals and sphincter;
• cholecystitis in chronic non-calculous form;
• angiocholitis;
• cholelithiasis;
• surgical interventions on the functioning of the gallbladder (in history);
• loss of appetite;
• nausea and vomiting (with increased bile secretion);
• chronic intestinal obstruction.

It is necessary to first consult a doctor regarding the appropriateness and effectiveness of such treatment, taking into account the individual characteristics and medical history of the patient.

The medication is intended for oral use at least half an hour before meals three times a day. A single dose ranges from 200 to 400 milligrams, but not more than 1.2 grams per day. The duration of the course of therapy is up to 14 days.

The instructions prohibit the use of a double amount in place of a missed dose of medication. In this case, therapy should be continued as usual.

Permissible doses

To avoid negative effects on the body when using Odeston, you should avoid alcohol during the entire treatment process. On average, therapy takes two weeks. However, the attending physician can change the dosage regimen and prolong the use of the medication. It all depends on the course of the disease.

If the drug is used as a course, the doctor may allow you to drink alcohol-containing drinks only after 3-30 days, depending on the advanced stage of the disease. You should also avoid drinking before and after therapy for a specified period of time:

• for women 14 hours before taking the drug;
• for men 8 hours before taking the drug;
• for women within 24 hours after finishing treatment;
• for men within 18 hours after the end of the dose.

Odeston should not be combined with alcohol during pregnancy or lactation.

If the prescribed dose of ethanol is violated, you must drink as much liquid as possible over the next 4 hours and stop further drinking alcohol.

The drug has no analogues in composition, but has drugs similar in their effects on the body (Allohol, Gepabene, Bonjigar, Holagol, Hofitol, Kholosas, Tanacehol, No-Shpa, Papaverine, Hepel, Febichol, Olimethine and others). The possibility of replacing one drug with another and simultaneous use with alcohol must be agreed with your doctor.

Problems in the functioning of the gallbladder are caused by pain and a feeling of bloating in the right hypochondrium. There are many reasons for the occurrence of diseases: genetic predisposition, untimely and unbalanced nutrition, age-related changes, environmental conditions. The drug Odeston will help improve digestion and the functioning of the stomach and gallbladder, and neutralize heartburn. This is a potent choleretic medicine for the treatment of diseases of the gastrointestinal tract.

Characteristics of Odeston

The drug is produced by a Polish pharmaceutical company in tablet form. Each tablet contains 200 mg of the active substance - hymecromone. In addition to this, the drug contains auxiliary components.

Under the influence of hymecromone, bile production is enhanced and its release into the intestines is improved. The substance also selectively relieves spasm of the smooth muscle muscles of the biliary tract and sphincter of Oddi. At the same time, the drug does not reduce the motility of the digestive organs and does not affect blood pressure. Thanks to the complex action of Odeston, bile stagnation decreases, its volume increases and the breakdown of fats in the intestines is normalized. The product eliminates cholestasis and prevents cholesterol crystallization.

Indications for use of the drug are:

• biliary dyskinesia;
• chronic cholangitis;
• hyperkinesia of the sphincter of Oddi;
• constipation caused by bile hyposecretion;
• noncalculous cholecystitis;
• dyspepsia and lack of appetite due to insufficient bile secretion;
• postoperative condition after interventions on the liver and gall bladder.

With the standard treatment regimen, Odeston should be taken 1 tablet three times a day for a 2-week course.

The use of the medicine is prohibited for:

• Crohn's disease;
• ulcerative colitis;
• intolerance to the components of the product;
• stomach and duodenal ulcers;
• obstructive gallbladder diseases;
• serious dysfunction of the liver and kidneys;
• under the age of 18;
• women while breastfeeding.

The medicine may cause the development of undesirable effects:

• allergy;
• epigastric pain;
• headache;
• flatulence;
• ulcerative lesions of the stomach;
• diarrhea.

"Odeston": instructions, reviews

The medicine is prescribed 30 minutes before meals. As a rule, adults are recommended to use 200-400 mg of Odeston 2 times a day. Thus, the daily dosage should not exceed 1200 mg. The medicine is not intended for long-term use - the course of therapy is usually 2 weeks. Before taking, you should definitely consult with your doctor, who will select an individual dosage based on the patient’s condition.

The drug has mostly positive reviews. It helps improve the condition of patients with gastrointestinal diseases, while preventing the occurrence of severe complications. Patients note improved digestion and a reduction in symptoms such as nausea and vomiting.

The influence of Odeston on the formation and excretion of bile

Digestion is a complex chemical conveyor belt in which several organs are directly involved. Bile is involved in food processing, helping the body digest fats contained in foods. Its source is hepatocyte cells, grouped inside the liver into hexagonal lobules. Inside each, a narrow tube opens - the bile duct. The liver is penetrated by a whole system of bile ducts. Eventually all the bile is collected in the common hepatic duct. However, it is spent as needed. When food enters the duodenum from the stomach, bile, which until that moment was stored in the gallbladder, is sent there.

The biliary tract includes the hepatic and cystic ducts

The drug Odeston has a choleretic effect. First, the muscles of the bile ducts are targeted. Secondly, the drug affects the functioning of the sphincter of Oddi - the place where bile is thrown into the duodenum. A spasm often occurs here, causing problems with bile secretion. Thirdly, Odeston promotes the synchronous functioning of the muscles of the entire gastrointestinal tract, preventing nausea, vomiting and the appearance of a bitter taste in the mouth due to the reflux of bile into the esophagus.

The biliary tract contains special smooth muscle

Terms and conditions of storage

Optimal storage conditions are a dark, dry place, protected from children and a temperature below 25 °C.

The medication should be stored at room temperature in a dry, dark place, protected from pets and children. Shelf life 36 months. The use of tablets after this time is strictly prohibited, regardless of how much the shelf life has been exceeded.

Store out of reach of children, at a temperature not exceeding 25 °C

Shelf life – 3 years.

Duration of therapy

Let's find out how long you can take Odeston. This drug must be used orally half an hour before meals. Adults are usually prescribed 200 to 400 milligrams three times a day. The daily dosage is a maximum of 1200 milligrams. The course of treatment is fourteen days. It is not advisable to take the described medication for longer than the specified period.

The choleretic “Odeston” is prescribed for children starting from the age of 7 years. They are prescribed 200 milligrams of medication (which corresponds to one tablet) one to three times. The daily volume should not exceed 600 milligrams, and the total course of treatment is two weeks.

If you miss a dose, take the medication as soon as possible. If the time for your next dose is approaching, then you should not take the missed tablet. You should not take a double dose of medication to compensate for a missed dose.

Hofitol

The drug is herbal - it is based on an extract from field artichoke. The medicine not only has a choleretic effect, it also promotes the restoration of liver cells and has a mild diuretic effect. Also, thanks to Hofitol, the production of liver enzymes is normalized, which improves the metabolism of cholesterol and fats. It contains vitamins B1, B2 and C, which further stimulates metabolism. Herbal origin allows the drug to be used at any age. Contraindications to this medicine include hypersensitivity, obstruction of the duct by a stone or tumor, as well as acute forms of liver, gallbladder, and kidney diseases.

Hofitol should be prescribed with caution to people with renal and liver failure. Some analogues of Odeston have a lower cost

So the price for 60 tablets of “Hofitol” is 220-300 rubles.

Price

Odeston can be purchased inexpensively in an online store from a catalog or ordered through pharmacies without presenting a prescription. Check out the approximate prices for medicine in Moscow in the table:

Allohol

This medicine, like the previous one, contains herbal ingredients. Its composition is animal dry bile, nettle and garlic extracts and activated carbon. The drug has a pronounced choleretic effect, normalizes bile production and prevents the formation of stones. In addition, there is stimulation of the secretion of other organs of the digestive system. The drug is also used for chronic hepatitis, uncomplicated cholelithiasis, initial cirrhosis of the liver, after removal of the gallbladder. Unlike the drug "Odeston", the price is 30-50 rubles for 24 tablets.

Choleretic drugs are necessary when there is a violation of the outflow of bile. However, they are contraindicated in the complete absence of bile excretion due to obstruction. In this case, another treatment is required. Any pathology of the digestive and other systems requires medical intervention, so therapy should be agreed with a specialist.

Odeston - composition, how to take a choleretic drug, compatibility with alcohol and contraindications

Problems in the functioning of the gallbladder are caused by pain and a feeling of bloating in the right hypochondrium.

There are many reasons for the occurrence of diseases: genetic predisposition, untimely and unbalanced nutrition, age-related changes, environmental conditions.

The drug Odeston will help improve digestion and the functioning of the stomach and gallbladder, and neutralize heartburn. This is a potent choleretic medicine for the treatment of diseases of the gastrointestinal tract.

According to the international drug classification system, tablets with the active substance gimecromone belong to the group of drugs with the code ATC A05AX02 - choleretic agents.

Bitterness in the mouth, nausea that often repeats for no reason, a feeling of heaviness, and discomfort may be symptoms indicating the need to undergo an examination to prescribe treatment.

The instructions for use of the drug are not a recommendation for self-medication, but serve to ensure correct administration and consideration of the characteristics of the drug.

The complete package consists of a cardboard box with five blisters or a plastic jar. The main active ingredient of the medicine is 7-hydroxy-4-methylcoumarin (hymecromone substance).

Odeston tablets belong to the group of choleretic drugs. Taking them increases the formation of bile, does not reduce gastrointestinal motility, and does not change blood pressure.

The drug has a mild antispasmodic effect on the bile ducts and sphincter of Oddi. The course of treatment reduces bile stagnation. This reduces the crystallization of cholesterol and the risk of cholelithiasis.