Medicines and drugs for headaches – Tempalgin

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Review of the headache painkiller Tempalgin (tablets). Video on the topic and a full description of the painkiller - how to use it, what is the dose, can it be used during pregnancy, what is the price of the tablets, and reviews about the medicine. Let's take a look below.

Tempalgin is a non-narcotic pain reliever, one tablet of which contains 2 components:

• metamizole sodium at a dosage of 500 mg,
• tempidone at a dose of 20 mg.

The drug is produced in the form of tablets, the appearance of which is familiar to many patients. Tempalgin is popularly called simply “green pills.” Sold in cardboard boxes in blisters of 10 pieces. One package can contain 10, 20 and 100 tablets for oral administration.

Tempalgin is manufactured by Sopharma, which is one of the leaders in the pharmaceutical industry in Bulgaria.

(Tempalgin is an effective remedy for headaches)

Contraindications

The drug should not be used in the following cases:

• hypersensitivity,
• severe renal/liver failure,
• CHF,
• glucose-6-phosphate dehydrogenase deficiency,
• “aspirin” asthma,
• pregnancy (first trimester and last 6 weeks),
• lactation period,
• children's age (up to 14 years);
• severe renal/liver failure,
• arterial hypotension (systolic blood pressure below 100 mm Hg),
• inhibition of hematopoiesis (granulocytopenia, leukopenia, agranulocytosis, cytostatic or infectious neutropenia).

Prescribed with caution for kidney diseases (pyelonephritis, glomerulonephritis, including a history), liver/renal failure of moderate severity, bronchial asthma, predisposition to the development of arterial hypotension, and long-term alcohol abuse

Tempalgin is able to eliminate various pains not associated with cranial and brain injuries.

In addition to headaches, the drug is prescribed for:

1. Toothaches;
2. Post-traumatic conditions;
3. Muscle, joint and bone pain;
4. Pain from burns;
5. Body temperature more than 38.5°C;
6. Menstrual syndrome.

Tablets are prohibited for:

1. ulcerative formations in the gastrointestinal tract;
2. renal and liver failure;
3. low blood pressure;
4. blood diseases;
5. heart failure;
6. allergic reactions to the composition and individual intolerance;
7. deficiency of glucose-6-phosphate dehydrogenase enzymes.

The drug is used with caution in the diagnosis of bronchial and aspirin-induced asthma, diseases of the gastrointestinal tract, liver and kidneys. The most common side effects are redness of the skin, swelling of the larynx, difficulty breathing, hallucinations, low blood pressure, lethargy and loss of consciousness.

The most common side effects are redness of the skin, swelling of the larynx, difficulty breathing, hallucinations, low blood pressure, lethargy and loss of consciousness.

A drug

— Pain syndrome (headache, neuralgia, toothache, migraine, myalgia, algodismenorrhea, arthralgia);

- visceral pain (renal, intestinal, hepatic colic) to potentiate the effect of antispasmodics;

- mild or moderate pain after diagnostic or surgical interventions.

Accept

— Arterial hypotension;

- severe renal or liver failure;

- deficiency of glucose-6-phosphate dehydrogenase;

- inhibition of hematopoiesis (neutropenia, leukopenia, agranulocytosis);

- pregnancy;

- aspirin asthma;

- childhood;

- lactation period;

- hypersensitivity.

How long does it take for the drug to work?

Another feature of the use of Tempalgin is the level of individual susceptibility of the components of the drug by the body of a patient suffering from toothache. One person can literally get rid of such a serious condition within 25 - 30 minutes; for another person, pills will not help at all.

How long does it take for the drug to work? The effect occurs no less than 20 minutes after taking the tablet . How long does it last? Depending on the individual characteristics of the human body, the effect can last up to 6.5 – 8 hours.

Mechanism of action of the anesthetic drug

Metamizole sodium in its action belongs to the group of non-narcotic analgesics and non-steroidal anti-inflammatory drugs. This substance has a powerful analgesic effect and moderate anti-inflammatory effect. Its good antipyretic properties are also known (it perfectly reduces body temperature during fever).

Tempidone is classified as a tranquilizer or anxiolytic. It relieves anxiety, eliminates agitation, including motor, anxiety, fear

Tempidone also helps to slightly reduce blood pressure, so people prone to hypotension should use the drug with caution

Both substances potentiate each other's action. The drug is quickly absorbed into the systemic bloodstream of the gastrointestinal tract and begins to act after 15-20 minutes. The maximum concentration is observed 2 hours after administration. The medicine is excreted by the liver and urine.

Metamizole sodium in its action belongs to the group of non-narcotic analgesics and non-steroidal anti-inflammatory drugs. This substance has a powerful analgesic effect and moderate anti-inflammatory effect. Its good antipyretic properties are also known (it perfectly reduces body temperature during fever).

Pharmacodynamics and pharmacokinetics

https://www.youtube.com/watch?v=https:l9Tt15e7zzQ

This drug is a painkiller and sedative. Its action is determined by the substances included in its composition.

Metamizole sodium has an analgesic and moderate anti-inflammatory effect, which is achieved by inhibiting cyclooxygenases type 1 and 2.

Tempidone helps eliminate anxiety, get rid of fear, reduce motor agitation and slightly reduce blood pressure. These substances are capable of potentiating each other's effects.

The drug is characterized by rapid absorption from the gastrointestinal tract. Its effect manifests itself after 30 minutes, and the maximum concentration in the blood is detected after 1-2 hours. The substance is metabilized in the liver. The drug is excreted from the body in the form of metabolites and partly in unchanged form along with bile and urine.

Pharmacological properties

The medicinal drug Tempalgin is a combination drug, the action of which is mainly aimed at eliminating pain and lowering body temperature. The drug is also capable of producing an anti-inflammatory effect on the patient’s body. In addition, there is a positive effect of the drug on the general psycho-emotional state of the patient, which improves due to the suppression of feelings of anxiety and restlessness.

The metamizole sodium component inhibits the synthesis of lipid elements, thereby non-selectively blocking the substances prostaglandin-endoperoxide synthase-1 and prostaglandin-endoperoxide synthase-2, which in turn makes it possible to stabilize the plasma membrane and prevent the formation of infectious pathogens.

The triacetonamine component has a pronounced calming effect. Through its effect on the patient’s body, it is possible to eliminate the feeling of fear, relieve tension and reduce psychomotor agitation. It also affects the speed and duration of the analgesic effect, which automatically increases several times.

The bioavailability of the drug is at the level of one hundred percent. Absorption of the active component occurs from the gastrointestinal tract. It reaches its maximum content in blood plasma one hour after application. The breakdown of the drug occurs in the liver, elimination is carried out by the kidneys.

What does the medicine contain?

Pharmacies offer the drug in tablet form. The package may contain several blisters of 10 units. Components:

1. Metamizole sodium.
2. Triacetonamine-4-toluenesulfonate.
3. Traditional additional components.

Mechanism of action of the drug

The active components of tempalgin act in several directions:

• As an antipyretic.
• As an analgesic.
• As an anti-inflammatory agent.
• As an anxiolytic.

Elimination of pain and inflammation is achieved through inhibition of cyclooxygenases due to the action of metamizole sodium. And tempidon helps fight anxiety, groundless fears and increased excitability.

Once in the gastrointestinal tract, the medicine is quickly absorbed, so a positive effect is observed within half an hour after taking tempalgin. After 2 hours, the concentration of the drug in the blood will be maximum. The process of metabolizing the drug occurs in the liver, and it is excreted from the body with urine and bile.

The medicine is suitable for use in the following diseases:

1. Myalgia and neuralgia.
2. Migraine.
3. Algodismenorrhea.
4. Toothache and headache.
5. For colic in various organs of the body.
6. To relieve pain after surgery.
7. At elevated body temperature.

( Video : "Tempalgin")

Application method and features

Dosage - adults can take no more than 3 tablets per day, at intervals of several hours. Children over 15 years of age: 2 tablets per day are allowed. Do not chew the tablets, take them with plenty of water. The permissible duration of treatment is 5 days.

To relieve pain that occurs after dental surgery, you need to take 1 tablet of the drug half an hour before the procedure.

In the presence of pathological processes in the liver: it is allowed to take 1 Tempalgin tablet per day.

Prescription of the drug in case of kidney disorders: 1 tablet per 24 hours.

The tablets are taken orally, swallowed whole and washed down with water, during or after meals.

The dose depends on individual sensitivity to the drug and the severity of the pain syndrome.

Recommended dosage:

• adults: 1 pc. 1–3 times a day. A single dose should not exceed 1 piece, the maximum daily dose should not exceed 4 pieces;
• children over 15 years old: 1 pc. per day, if necessary to achieve a therapeutic effect, the maximum permissible daily dose is allowed - 2 pcs.

To relieve pain during dental procedures, take 1 Tempalgin tablet 0.5 hours before the procedure.

Elderly patients do not require dose reduction.

For moderate or severe liver dysfunction and functional kidney damage in adult patients, it is recommended to use a daily dose of the drug in an amount of no more than two tablets.

Do not exceed the recommended dosage or treatment period without consulting a physician.

The normal regimen for using this drug is to take one tablet in the morning, lunch and evening. The dosage can be reduced to one tablet every twenty-four hours or increased to six as prescribed by the attending physician. It is not recommended to use the medicine for more than five days in a row.

Instructions for use

The tablets should be prescribed by a doctor based on the symptoms of the disease. The doctor can finally establish the required dosage only after diagnosis. If the patient suffers from constant pain, then resorting to self-medication is quite unsafe.

If discomfort rarely occurs, you can use this remedy without visiting a doctor. However, we should not forget that this is only permissible if the pain is not systematic and the contraindications are fully taken into account. In this case, it is very important to use Tempalgin tablets correctly.

The use of this product, according to the instructions, is as follows:

1. The tablets should be taken after meals. The pills are not intended to be chewed. They should be swallowed whole with a glass of water.
2. Adults and children over 14 years old are recommended to take 1 tablet 2-3 times a day.
3. For severe pain, you can increase the above dosage by 2 times. But such an appointment must be agreed with a doctor.
4. The maximum daily dose of this medicine should not exceed 6 pills.
5. You should not take Tempalgin tablets for more than 5 days. This is especially true if the patient takes an increased dose. For a longer period, only a doctor can prescribe pills.

special instructions

During the period of use of Tempalgin, colloidal blood substitutes, radiocontrast agents and penicillin should not be prescribed.

Alcohol consumption is contraindicated.

With concomitant cytostatic therapy, the patient should be under regular medical supervision.

Due to the risk of developing agranulocytosis, immediate discontinuation of the drug is required if conditions of unknown origin appear: chills, fever, sore throat, stomatitis, difficulty swallowing, development of proctitis or vaginitis.

If it is necessary to take the drug for a long time (more than 7 days), the patient should ensure regular monitoring of the functional state of the liver and blood count.

It is strictly forbidden to take Tempalgin tablets for acute abdominal pain until their clinical cause is determined.

During therapy with this drug, it is important to be aware of the following recommendations:

1. The drug should not be used for abdominal pain of unknown nature.
2. It is strictly forbidden to combine tablets with ethanol.
3. It is advisable to refrain from driving and operating dangerous machinery for the duration of treatment.

In addition, try to always consult a doctor before taking medications. This will not only effectively treat the disease, but will also protect you from negative side effects.

"Tempalgin", what does this analgesic - antipyretic - help with? The medicine has antipyretic and analgesic properties. Tempalgin is good for headaches and toothaches.

Reviews

Nikita, 43 years old (Stavropol): “Due to the specifics of my work (I’m an accountant), I often get headaches. I always save myself with Tempalgin - this is one of the few painkillers that really helps me. The good news is that the effect comes quite quickly - literally after 20 minutes the pain dulls, and if it is not too strong, it goes away completely. I always keep Tempalgin’s record in my desk drawer.”

Irina, 23 years old (Samara): “I have suffered from migraines since my student years. I drank so many painkillers that I can’t even count all the names of the pills. About six months ago, a friend advised me to try Tempalgin, saying that it copes well with severe toothache, and maybe it can also cope with migraines. I bought pills and took 2 of them at once. It helped, now it’s the only way I can save myself.”

Veronika Tarasova, dentist: “As a premedication for patients who are about to undergo an intervention to remove a tooth or open an abscess on the gum, I prescribe Tempalgin tablets. In addition to being an anesthetic, it also has a sedative effect. This is especially good for boys and girls aged 15 or older. The drug acts quickly, and its effect lasts for 5 hours or more.”

The use of Tempalgin for various types of pain is completely justified. Many patients claim that the drug, despite a large list of adverse reactions, did not cause them any ailments. However, these are only subjective opinions and should not be relied upon under any circumstances. And although this medicine is freely available in pharmacies, it is advisable to consult a doctor before taking it.

Numerous reviews of Tempalgin indicate that it is often quite effective. The tablets are good for menstruation, toothache and headaches. At the same time, patients often discuss Tempalgin tablets, what do they help best with?

It should be noted that this drug affects everyone differently. For example, for some, in addition to eliminating pain syndromes, it also lowers or increases blood pressure, while others do not feel any effect at all. As a rule, the reason for this lies not in the intensity of pain, but in the causes they cause.

Sometimes there are reports that patients take this medicine for a long time as a pain reliever. As a result, they begin to ask on forums how Tempalgin works, what it helps with, and what it is usually prescribed for? There are cases where people reduced pain with the help of these tablets, which led to the development of chronic forms of the disease.

Of course, there are times when taking painkillers is necessary. However, if the pain does not go away, then you need to consult a doctor. It is important to know when taking Tempalgin what it helps with and what it can lead to. The development of pathological processes and difficulty in making an accurate diagnosis cannot be ruled out.

Use during pregnancy and lactation

No negative effects on fertility have been established.

Tempalgin at

prescribed with caution. During the I and III trimester, the drug is contraindicated, because

the tranquilizing component (triacetomine) included in its composition can easily penetrate the placental barrier into the blood and

fetus This substance can cause irreparable damage to the brain of the unborn baby.

Tempalgin should not be taken by pregnant women (it has a negative effect on the development of the fetus), regardless of the stage of pregnancy, and by nursing mothers, since both substances are excreted into breast milk.

Tempalgin is strictly prohibited during pregnancy

(Tempalgin is strictly prohibited during pregnancy)

If the recommended doses are exceeded, the patient may experience nausea with vomiting, abdominal pain, decreased blood pressure, general weakness, rapid heartbeat, shortness of breath, drowsiness, and convulsions.

First aid includes the following activities:

• gastric lavage,
• taking sorbents and laxatives.

In severe cases, emergency hemodialysis and symptomatic therapy are resorted to.

Compound

active ingredients: metamizole sodium monohydrate, Tempidone (Triacetonamine-4-toluene sulfonate)

1 film-coated tablet contains metamizole sodium monohydrate 500 mg Tempidone (Triacetonamine-4-toluene sulfonate) 20 mg

excipients: wheat starch, microcrystalline cellulose (type 101), povidone K 25, talc, magnesium stearate

film coating: Opadry II 85 F21526 green (partially hydrolyzed polyvinyl alcohol, macrogol 3350, talc, titanium dioxide (E 171), quinoline yellow (E 104), brilliant blue FCF (E 133)).

Having gained an idea of ​​the drug “Tempalgin”, what the medication helps with, let’s consider what determines its effectiveness. As mentioned above, the product is a combination drug. It contains sedative and analgesic components.

The main substances that provide a beneficial effect are:

1. Metamizole sodium. This component is a powerful analgesic. It is able to eliminate small inflammatory processes occurring in the body.
2. Tempidon. This substance eliminates the patient's feeling of fear, anxiety, and restlessness. It reduces motor excitability. Lowers blood pressure slightly.

However, the effectiveness of the product lies precisely in the combination of these substances. Because they enhance each other's impact. It is thanks to such a successful combination that most people know very well when it comes to the drug Tempalgin what this remedy helps with, and if necessary, use it.

Tempalgin belongs to the class of combined painkillers. It contains 2 active substances - metamizole sodium and tempidone. The medicine is produced in Bulgaria.

Due to its color, the drug is popularly called “green pills.” The average price for Tempalgin in Russia ranges from 129 to 412 rubles.

As already noted, the drug contains 2 active ingredients, each of which has its own characteristics of influence on the body during headaches:

1. Metamizole sodium. This substance belongs to the group of non-narcotic analgesics. At the same time, it has an anti-inflammatory effect, but the analgesic effect is much more pronounced. It can also be used as an antipyretic, but with a slight increase in body temperature.

   Metamizole sodium

2. Tempidone is a tranquilizer and anxiolytic. Helps eliminate increased psycho-emotional agitation, feelings of anxiety or restlessness. Another therapeutic effect is hypotonic, so people with low blood pressure are not recommended to take Tempalgin as an analgesic during an attack of hypotension.

Despite the striking contrast of these substances, they complement each other perfectly. In addition, each component enhances the effectiveness of the other.

Tempalgin tablets are quickly absorbed into the gastrointestinal tract. The therapeutic (analgesic and antipyretic) effect is achieved 15-25 minutes after taking the medicine. Remains of the medication are excreted by the kidneys (during urination) and also by the liver.

Interaction with other drugs

Concomitant use of phenothiazine derivatives can provoke hyperthermia. The analgesic effect of Tempalgin is enhanced by tranquilizers and sedatives. The risk of leukopenia increases when prescribed simultaneously with cytostatics and thiamazole. Metamizole sodium causes a decrease in plasma concentrations of cyclosporine.

Strengthens the effect of GCS, indirect anticoagulants, hypoglycemic drugs, indomethacin. The effect of metamizole sodium is weakened by inducers of liver enzymes (phenylbutazone, barbiturates). The toxic effects of simultaneous administration of metamizole sodium and NSAIDs, oral contraceptives, tricyclic antidepressants, and allopurinol are mutually reinforcing. The elimination of metamizole sodium is slowed down by propranolol, codeine, and H2 receptor blockers.

Overdose symptoms

Taking Tempalgin in dosages exceeding the maximum allowable - that is, more than two tablets at a time and more than six per day - can provoke certain problems with well-being:

• pain in the epigastric region, nausea and vomiting;
• decreased blood pressure;
• tachycardia;
• the occurrence of tinnitus;
• shortness of breath;
• feeling tired and drowsy;
• convulsive muscle spasms;
• some confusion.

If any of the listed symptoms of an overdose of this medicine occur, it is necessary to perform gastric lavage as quickly as possible and take activated charcoal or another drug with a highly absorbent effect.

Synonyms of nosological groups

Temperature no higher than 25 degrees Celsius, exclude exposure to light and moisture.

The drug "Tempalgin": indications for use

The medicinal properties of the main components of this medicine are widely used in modern medicine. And probably many have heard about exactly in which cases it is recommended to use the drug Tempalgin. Indications for use are pain of various origins. For example, tablets help get rid of severe headaches and toothaches. In addition, the drug is used to relieve pain in myalgia, neuralgia, algodisminorrhea and migraines. The drug "Tempalgin" is used during menstruation - women confirm that it helps to quickly get rid of unpleasant pulling sensations in the lower abdomen. This remedy also copes with joint pain due to arthritis. Indications for use are also mild pain that occurs after surgery or diagnostic procedures. In combination with antispasmodics, this pain reliever is taken for hepatic, renal and intestinal colic.

Description of the medicine

So, what is “Tempalgin” for? The medication has a complex effect on the human body.

It has the following properties:

• analgesic;
• antipyretic;
• sedative.

Most people know what Tempalgin helps with and, if necessary, resort to this medication. The product quite effectively eliminates pain syndromes provoked by a variety of factors. This medicine is often used for severe migraines. This medication is used for toothache and many other pathologies that cause unpleasant discomfort in a person.

The medicine is an antipyretic. Therefore, you should know what Tempalgin can get rid of. The medication is used for febrile conditions and high temperatures. Often this remedy is included in complex therapy for acute respiratory viral infections and influenza.

In addition, the medicine can have a calming effect on the nervous system. The drug can eliminate such negative manifestations as fear, motor agitation, and anxiety. Taking the medicine helps lower blood pressure.

The product has a quick effect on the body. After taking the medication, the sedative effect will appear within half an hour. Analgesic effects can be expected within 1-2 hours.

Indications for use

The list of things that Tempalgin tablets help with includes the following pathologies and conditions:

1. Pain syndrome in moderate or weak form. The drug effectively eliminates toothache, migraine, neuralgia, headache, myalgia, radicular syndrome, arthralgia, and algodismenorrhea. It perfectly relieves even those people who have increased excitability from such conditions.
2. Pain of visceral origin, mild. Tablets are included in therapy, in combination with antispasmodics, for intestinal, renal, and hepatic colic.
3. Pain caused by surgical or diagnostic interventions. The drug acts as an adjuvant.
4. Hyperthermia for colds and various infectious and inflammatory diseases.

However, patients should understand what Tempalgin tablets can really help with. This medicine is not a narcotic drug. Therefore, it cannot be classified as a powerful medicine. Tempalgin tablets are significantly inferior in analgesic effect to those drugs that contain a narcotic component. Consequently, this remedy simply cannot eliminate severe headaches and migraines.

Such patients will need a stronger medicine than Tempalgin.

Release form and composition

The drug belongs to a special group of combined non-narcotic analgesics. This remedy also has a moderate sedative effect and is used to eliminate various types of pain.

International nonproprietary name is the name of the active substance that determines the effect of the drug. This medicine contains more than one active ingredient. Therefore, it is classified as a combination drug. INN Tempalgina - metamizole in combination with tempidone.

Action of non-narcotic analgesics

It is used in various fields of medicine. The drug is used to relieve pain of various localizations (pain in the teeth, stomach, head, back, etc.).

This product is produced in the form of tablets for internal use. These tablets are greenish in color and have a round, convex shape. Their diameter is 1.3 cm. They are packaged in foil blisters of 10 pieces. In total, a cardboard box contains 10, 20, 100 or 300 tablets.

You can purchase medicine by placing an online order at an online pharmacy. At the same time, its cost is practically the same (sometimes even cheaper). In addition, such stores provide fast delivery directly to your home.

Components

Tempalgin contains two active components. One tablet contains:

• metamizole sodium salt (500 mg);
• tempidone (20 mg).

Pharmacodynamic properties are provided by the active components of the drug:

• Metamizole sodium is classified as a pyrazolone derivative (non-steroidal anti-inflammatory drug). Its action is based on suppressing the activity of cyclooxygenase, which produces prostaglandins. This component provides:
• analgesic;

weak anti-inflammatory;

• antipyretic effect. Metamizole also has a membrane-stabilizing effect and inhibits the formation of endogenous pyrogens.

  The effects of analgesics on the body

Metamizole is rapidly hydrolyzed in the digestive tract. Its highest level in the blood is observed two hours after administration. The transformation of active components occurs in the liver with the formation of active metabolites. They are excreted by the urinary system. In cases of impaired hepatic or renal function of the kidneys or liver, the half-life is significantly prolonged.

Tempidone is absorbed primarily in the stomach. Moreover, its maximum concentration is observed within an hour after application. It is excreted unchanged by the kidneys.

Dosage form – coated tablets: round, biconvex, green (10 pieces in a blister, 2 or 10 blisters in a cardboard box or 30 blisters in a box).

1 tablet contains:

• active ingredients: metamizole sodium – 0.5 g, tempidone (triacetonamine-4-toluene sulfonate) – 0.02 g;
• auxiliary components: wheat starch, microcrystalline cellulose, magnesium stearate, collidon K25 (crospovidone), titanium dioxide, castor oil, polyethylene glycol 400, dibutyl phthalate, glycerol, acetone (eudragit L-12.5), talc, green dye.

Tempalgin is produced in film-coated tablets, packaged in blisters of 10 pieces, 2, 10 and 30 blisters per pack.

The tablets contain active ingredients: metamizole sodium and triacetonamine-4-toluenesulfonate.

Tempalgin price, where to buy

The price of Tempalgin tablets varies between 103-400 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Tempalgin tab. p.o n100Sopharma AD
• Tempalgin tab. p.o n20Sopharma AD

Pharmacy Dialogue

• Tempalgin (tablet no. 20)

Europharm* 4% discount using promo code medside11

• Tempalgin n20 tabSopharma JSC
• Tempalgin No. 100 tabSopharma JSC
• Tempalgin No. 10 tabSopharma JSC

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Pharmacy24

• Tempalgin No. 10 tablets AT "Sopharma", Bulgaria
• Tempalgin N20 tablets AT "Sopharma", Bulgaria

PaniPharmacy

• Tempalgin tablets Tempalgin tablets. p/o No. 10 Bulgaria, Sopharma
• Tempalgin tablets Tempalgin tablets. p/o No. 20 Bulgaria, Sopharma

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Side effects

Almost all medications can cause undesirable symptoms in the patient. The drug Tempalgin is no exception. The use of this drug, extremely rarely, can cause side effects. Such a clinic is most often observed as a result of long-term use or use of maximum doses. Sometimes negative reactions are triggered by taking several medications at the same time. In addition, individual intolerance cannot be ruled out.

Side effects may include symptoms:

1. Digestive system. Burning sensation in the epigastric zone, dry mouth, increased activity of liver transaminases, cholestasis, jaundice, hyperbilirubinemia.
2. CNS. Headache, dizziness, and sometimes hallucinations occur.
3. Cardiac and vascular systems. Tachycardia, changes in pressure (increase, decrease), cyanosis.
4. Urinary system. If the drug is taken in large doses, kidney disorders may occur, such as oliguria, interstitial nephritis, anuria, proteinuria. Sometimes red colored urine is observed.
5. Hematopoietic system. Leukopenia, thrombocytopenia or agranulocytosis.
6. Allergic reactions. Itching, skin rash, urticaria, Quincke's edema, exudative erythema, bronchospasm, toxic epidermal necrolysis, anaphylactic shock.

Side effects

When taking Tempalgin M tablets, side effects may develop: headaches, dizziness, hallucinations, jaundice, cholestasis, hyperfermentemia, hyperbilirubinemia, epigastric pain, vomiting, nausea, pressure disturbances, tachycardia, cyanosis, leukopenia, thrombocytopenia, agranulocytosis, proteinuria, oliguria, etc. Further.

In addition, the development of allergic effects in the form of urticaria, Quincke's edema, skin itching, exudative erythema, bronchospasm, and anaphylactic shock is possible.

Long-term use of Tempalgin or a violation of the dosage can cause side symptoms:

1. Circulatory system: leukopenia, anemia.
2. Immune reaction: rash on the skin, itching and peeling, shortness of breath, swelling of soft tissues.
3. Metabolism: lack of appetite.
4. Central nervous system: attacks of dizziness, intense and prolonged headaches.
5. Organs of the digestive system: nausea and vomiting, abdominal pain.
6. Kidneys: anuria, impaired renal function.

If the medicine is taken for more than 7 days, a person may experience pathological conditions such as bleeding gums and a temporary increase in body temperature.

Physiology of the effects of alcohol on the body and its consequences

The main substance that is part of alcohol is ethanol. It is this substance, together with water or other components, that forms alcoholic drinks and is responsible for the state of intoxication. When entering the digestive system, ethanol molecules are absorbed into the walls of the stomach, enter the blood and spread throughout the body. Penetration into the brain provokes a lack of oxygen in the cells and causes partial asphyxia of the nervous tissue.

Under the influence of toxic effects, the functionality of the brain sharply decreases, and the state accompanying this process is perceived by a person as intoxication. As a result of lack of oxygen, some nerve cells die and are no longer restored. Systematic intake of alcohol can lead to partial necrosis of nervous tissue and the formation of problems with blood supply to the brain. In addition, spreading throughout the body along with the blood, ethanol penetrates almost all human organs and tissues. The first to take the hit is the stomach, directly into which the alcohol enters. At the same time, the removal of most of it from the body is ensured by the liver and kidneys, which also suffer quite severely.

Alcohol can have a positive effect on a person, but only when it is consumed moderately and quite rarely. In this case, drinking alcohol makes it possible to relieve tension from the nervous system, reduce excitability and relax muscles.

Drug analogues

The only drug that has a similar composition to the drug Tempalgin is the drug Tempanginol.

However, there are many drugs that have similar effects on the human body.

Among them are drugs:

• "Betalok";
• "Askofen";
• "Analgin";
• "Novigan";
• "Pentalgin";
• "Solpadeine";
• "MIG 400";
• "Nurofen".

Tempalgin can be replaced with analogues that have the same effect on the body: Andifen, Tempimet, Sedal-M, Tetralgin.

The drug has the following analogue agents with similar spectrum of action: Tempanal, Tempimed, Tempaldol, Tempanginol.

Analogs (synonyms) of Tempalgin, which contain the same active components, are:

• Tempaldol;
• Tempanal;
• Tempanginol;
• Tempimed;
• Metamizole sodium Triacytonamine-4-tolusulfonate.

Interaction of Tempalgin with drugs

It may be prescribed in combination with other drugs, with which it may behave differently. Here are the most common combinations and their interactions.

Tempalgin reviews

Marina, 23 years old: Since my youth, I started having terrible PMS pain. I have tried the effects of many tablets on myself, but for the past year I have been saving myself with Tempalgin. He copes perfectly, as soon as “this” day looms on the calendar, I take a pill of medicine in the morning and for all four days I feel great, nothing bothers me.

Tatyana, 43 years old: I used Tempalgin for a long time for toothache and headaches, until one day I injured my leg, I overdid it and took two tablets rather than the prescribed one. I repeated this course for a week, as a result I began to fall asleep right on the go, probably the medicine had a cumulative effect, but I didn’t take this into account. The pain went away, but the aches and drowsiness persisted for a couple of days after I stopped taking the pills.

Briefly about the drug

The drug is classified as a non-narcotic. The painkiller is available and effective. It can be found in almost every pharmacy. When using Tempalgin, you should understand that the medicine can mask existing diseases.

The analgesic contains:

• metamizole sodium;
• microcrystalline cellulose;
• dibudyl phthalate;
• talc;
• glycerol;
• tempidon;
• titanium dioxide;
• magnesium stearate;
• wheat starch;
• Castor oil;
• povidone.

Metamizole sodium and tempidone help achieve sedative and analgesic effects. The first is capable of inhibiting the production of cyclooxygenase. This enzyme takes part in the synthesis of prostanoids (lipid physiologically active substances).

Tempidon helps cope with psycho-emotional changes. It eliminates anxiety, fear, panic and depression. The drug is prescribed for motor agitation and muscle hypertonicity.

The main active components of the drug enhance the therapeutic effect of each other. After oral (swallowing) administration, the effect of the analgesic can be felt after 120 minutes. The drug is excreted in urine and feces.

The medicine is used in the form of pills. Before using it, you should consult a specialist. Contraindications and adverse reactions should be taken into account when using an analgesic.

Drug price

With simultaneous use of Tempalgin:

• phenothiazine derivatives, including chlorpromazine, increase the risk of developing severe hyperthermia;
• ethanol enhances its effect;
• sedatives, tranquilizers increase the analgesic effect of the drug;
• thiamazole, cytostatics increase the likelihood of developing leukopenia;
• glucocorticosteroids, oral hypoglycemic drugs, indomethacin, indirect anticoagulants are displaced from protein binding and increase their effect;
• inducers of microsomal liver enzymes, including phenylbutazone, barbiturates reduce the effect of metamizole sodium;
• cyclosporine reduces its concentration in blood plasma;
• tricyclic antidepressants, other non-opioid analgesics, oral contraceptives, allopurinol may cause mutually reinforcing toxic effects;
• codeine, propranolol, histamine H2 receptor blockers enhance the effect of the drug.

Keep away from children.

Store in a place protected from light and moisture at temperatures up to 25 °C.

Shelf life – 4 years.

Reviews of Tempalgin indicate that this non-narcotic analgesic is well tolerated by patients, effectively eliminates pain and has an antipyretic effect in most cases. Many patients also point to the positive sedative effect of this drug, which helps eliminate

and nervousness.

In rare cases, patients who took Tempalgin other than as prescribed by a doctor experienced side effects of the drug. There are no patient reviews of cases of overdose. Hypersensitivity to the components of Tempalgin has been observed rarely.

Most patients assess the cost of Tempalgin as “acceptable”.

The price of Tempalgin depends on the number of tablets in the package and the pharmacy selling the drug. This drug can be purchased without a doctor's prescription both in regular pharmacies and on online pharmacy websites.

• 10 tablets in a cardboard package – from 30 to 36 rubles;
• 20 tablets in a cardboard package – from 59 to 87 rubles;
• 100 tablets in a cardboard package - from 227 to 281 rubles.

Psychotropic and sedatives may enhance the analgesic effect of metamizole sodium.

The use of methimazole and antitumor drugs affects the accelerated decrease in the level of leukocytes in the blood

Combined use with medications made on the basis of 10H-phenothiazine can lead to a significant increase in body temperature.

Medicines that have a depressant effect on the central nervous system neutralize the positive effect of the active component metamizole sodium.

The use of the drug in combination with non-narcotic painkillers and psychotropic drugs with a tricyclic structure can increase the toxicity of these drugs.

In pharmacies, medications are sold without necessarily having a prescription from the attending physician.

Patient reviews of this drug are predominantly positive. Many note its speed and effectiveness for headaches, joint pain, and toothaches. Some patients call Tempalgin a universal remedy that relieves various types of pain, and always keep it in their home medicine cabinet.

The average price of a pack of Tempalgin (20 tablets) is 120-130 rubles. The drug belongs to the over-the-counter group of drugs and is sold freely.

“Actually, I’m not a fan of taking medications, but sometimes you just can’t do without them. It was at such a moment that I became acquainted with Tempalgin tablets. About a year ago, while preparing a quarterly report at work, I got a severe headache. Self-massage did not help this time, and I went around the office to look for another remedy.

“I take Tempalgin regularly, about 1-2 tablets per month, to eliminate women’s pain during menstrual periods. Always helps, has never let me down yet. True, it has many side effects, but I have never experienced anything like it.”

“Headaches have been bothering me often since my school years. I tried many medications, among which was Tempalgin. These pills relieve pain well, but my stomach hurts after them, so I try not to drink often, and if I have to, I try to put something in my mouth and only then take the pill, so as not to go on an empty stomach.”

The drug Tempalgin

Tempalgin is a combination drug that includes:

• metamizole sodium – 500 mg;
• triacetomine – 20 mg;
• excipients (wheat starch, microcrystalline cellulose, magnesium stearate, etc.).

This drug, which belongs to the group of non-narcotic analgesics, has a pronounced and long-lasting analgesic and antipyretic effect. In addition to them, Tempalgin has a mild anti-inflammatory and mild sedative (calming) effect. Due to the presence of triacetomine in the tablet, the effect of the analgesic component - the drug metamizole - is enhanced and prolonged.

Due to its effectiveness and many additional effects, this non-narcotic pain reliever is very popular among consumers. Tempalgin is available only for oral administration in the form of biconvex round tablets coated with a rich green enteric coating. The tablets are packaged in blisters of 10 pieces - 10, 20, 100 and 300 tablets in a cardboard package.

Instructions for use of TempalginIndications for use

• Pain syndrome in patients with increased excitability of the nervous system (migraine, pain during menstruation, toothache, headache, neuritis, neuralgia, pain in joints and muscles, pain from injuries, wounds, burns, etc.);
• renal, hepatic or intestinal colic (in combination with antispasmodics);
• pain relief before dental procedures;
• pain in the postoperative period;
• pain after invasive diagnostic procedures;
• increased body temperature in viral and infectious-inflammatory diseases.

Contraindications

• Decrease in blood pressure below 100 mm. Hg Art.;
• severe liver and kidney diseases;
• acute hepatic porphyria;
• “aspirin” asthma and tendency to bronchospasm;
• aplastic anemia;
• agranulocytosis;
• leukopenia;
• periods: pregnancy (especially the first and third trimesters), lactation;
• age up to 15 years;
• hypersensitivity to any component of the drug.

Side effects

Side effects when taking Tempalgin are rare, but still possible:

• cardiovascular system – tachycardia, decreased blood pressure, cyanosis, palpitations;
• nervous system – dizziness, headache;
• hematopoietic system – leukopenia, thrombocytopenia, aplastic anemia, agranulocytosis, hemolytic anemia;
• respiratory system – breathing disorders, bronchospasm (if there is a predisposition);
• digestive system - discomfort and pain in the abdomen, nausea, vomiting, cholestasis, increased levels of bilirubin, ALT and AST, the appearance of ulcers and bleeding;
• skin – necrotic processes in the mouth, ears, nose, genitals;
• immune system – skin itching, urticaria, angioedema, anaphylaxis.

How to take Tempalgin?

1. Tempalgin tablets should be taken during or after meals, without chewing and washed down with the delivery amount

2. You should not take this drug with long-term alcohol abuse and take alcohol at the same time as Tempalgin.

3. Cannot be taken during treatment with colloidal blood substitutes,

penicillin antibiotics

and the introduction of radiocontrast agents into the body.

4. Should not be used to treat abdominal pain if its cause is unclear.

5. With long-term use, it is necessary to monitor blood composition and liver functions.

6. Children and adolescents under 18 years of age can take the drug only under medical supervision and for no more than 5 days.

7. After taking the drug, you should not drive a vehicle or complex machinery, or engage in activities that require increased concentration.

8. The patient should not be alarmed when urine turns red after taking Tempalgin.

9. When taking Tempalgin for a long time, it is recommended to simultaneously take drugs that protect the gastric mucosa (

Ranitidine

or others).

Tempalgin dosage

• 1 tablet 1-3 times a day;
• if ineffective, you can take 1 more tablet (maximum single dose - 2 tablets).

The frequency of taking Tempalgin depends on the severity of the pain syndrome, but the maximum daily dose should not exceed 6 tablets. It is not recommended to take this drug for more than 5 days. Increasing the duration of use can only be done under the supervision of a physician. Overdose

An overdose of Tempalgin can occur if the recommendations set out in the instructions are not followed, if the doctor’s recommendations are not followed, and if there are suicide attempts. Expression and combination

symptoms

in case of overdose depends on the condition

health

, the dose of the drug and the time of its effect on the body.

Overdose symptoms:

• nausea or vomiting;
• blood in stool;
• noise in ears;
• breathing problems or apnea;
• hemorrhagic diathesis;
• oliguria or anuria (decreased amount of urine);
• toxic-allergic shock;
• abnormalities in the blood picture.

At the first signs of overdose you should:

• rinse the stomach;
• take a saline laxative;
• take sorbents;
• consult a doctor.

In severe cases, resuscitation measures may be necessary. Tempalgin: instructions for use - video Tempalgin for children

Tempalgin is not recommended for the treatment of pain and fever in children under 15 years of age. Also, this drug is not used to treat children over 15 years of age for more than 5 days, because with long-term use, it can contribute to a disruption of the blood picture and the development

What does Tempalgin help with?

Tempalgin for headaches

Tempalgin for toothache

Tempalgin during menstruation

Tempalgin can be used to treat pain that accompanies menstruation. This drug, in addition to the analgesic effect, eliminates the signs of nervousness and tearfulness that often accompany painful menstruation due to hormonal imbalance.

For pain during menstruation, the doctor may recommend the use of antispasmodic drugs (for example, No-shpa) in parallel with Tempalgin.

Tempalgin and blood pressure

Compatibility of Tempalgin and alcohol

The instructions do not say anything about the compatibility of alcohol and the drug. The main substance of alcoholic drinks, ethanol, creates the effect of intoxication. Penetrating into the brain, it causes oxygen deficiency and slight asphyxia of the nerve material, so some neurons die completely. Regular consumption of alcoholic beverages leads to partial necrosis of the nerve material and the creation of difficulties with the blood supply.

The first hit of ethanol goes to the stomach, but the removal of waste products is carried out by the liver and kidneys, which also suffer.

Alcohol is a kind of antipsychotic and relieves mental stress, reduces nervousness and relaxes muscle tissue. But sometimes people abuse alcohol. This leads to the development of diseases, the first symptom of which is pain. Therefore, using Tempalgin and alcohol together is not uncommon.

The instructions do not talk about the effect of ethanol, but list an increase in possible reactions:

• rash and redness on the skin;
• decreased blood pressure;
• disruption of the cardiac and vascular system;
• loss of appetite;
• asthmatic attacks;
• lightheadedness, disgust and vomiting.

Both substances are excreted through the urinary system and liver. In this case, the activity of two organs is aimed at removing toxins. Therefore, the processing of the active substances of the drug is delayed and entails negative consequences of Tempalgin with alcohol:

• destabilization of the functions of the urinary system;
• decreased liver performance;
• allergies;
• disorder of the cardiac and vascular system.

Ethanol increases the effect of Tempalgin substances on bone marrow material and blood cells, which are injured and destroyed. The result is the development of the following diseases: leukopenia, aplastic anemia, and agranulocytosis.

Tempalgin after alcohol, how long after can you drink it? The removal of ethanol from the body depends on the norm and weight of the person, but is generally carried out within 6-8 hours. The best time is 12 hours after drinking alcohol, you can take an analgesic tablet.

Be healthy!

Source: zdravoline.info

Is Tempalgin compatible with alcohol?

The use of the drug helps to cope with muscle pain and migraines that occur with colds and other ailments. Some people, hoping to enhance the effect of drug therapy, use alcohol for treatment. The annotation does not contain information about whether Tempalgin can be taken after alcohol.

The medication itself can cause the following negative reactions:

• rashes on the skin and mucous membranes;
• decreased blood pressure (blood pressure);
• problems with appetite;
• nausea;
• redness on the skin;
• vomiting;
• disturbances in the functioning of the heart muscle;
• asthma attacks;
• dizziness.

Any side effect may be worsened if you drink alcohol with the tablet. In combination with medication, a strong drink will provoke a worsening of the condition. Both components are excreted by the kidneys and liver.

Organs perform a filtration function. Their main task is to remove toxic substances. When taken together, the load on the liver and kidneys will increase significantly. As a result, the detoxification process will proceed at a slower pace.

conclusions

Tempalgin is a combination drug that combines sedative and analgesic properties. The simultaneous use of strong drinks is not recommended, since with regular and long-term use it harms the hematopoietic system, has a strong inhibitory effect on the central nervous system, and also contributes to disruption of the liver, kidneys, blood vessels and heart. In addition, ethanol significantly increases the manifestation of side effects and increases the concentration of Tempalgin in the blood, which undoubtedly leads to an overdose of the drug. In any case, whether to drink or not to drink is up to you, but you should think about whether the game is worth the candle?

Use for alcoholism

A person suffering from chronic alcoholism has seriously impaired liver and renal function. The active substances are broken down in the liver. With systematic ethanol poisoning, the organ cannot process the medicine in a timely manner.

The efforts of hepatocytes (liver cells) are aimed at ridding the body of alcohol toxins. The medication doubles the load on hepatocytes, causing toxic liver damage.

Weakened kidneys are exposed to identical effects. The kidney glomeruli cannot efficiently filter the blood to remove toxins from the body.

Chronic alcohol effects on the nervous system and brain cause neuropsychiatric disorders. Tempidone, as part of the drug, aggravates the state of alcoholism and causes dysfunction of neurons (brain cells).

Therapy is permitted in case of prolonged absence of ethanol in the blood in the stage of stable alcoholic remission.

How to use Tempalgin correctly for high blood pressure?

Considering the fact that the sedative effect of the drug dilates the blood vessels, the level of blood pressure automatically decreases. Therefore, this medicine can be taken by hypertensive patients. If you have hypotension, it is better not to use this medication, but it is permissible to use it only if your blood pressure is very slightly reduced.

There are certain rules for taking Tempalgin for blood pressure that must be strictly adhered to:

• the drug is taken orally during a meal or immediately after a meal;
• It is recommended to drink plenty of water;
• It is not recommended to use Tempalgin along with alcoholic beverages;
• if you adhere to antibacterial therapy or use colloidal blood substitutes, discard Tempalgin, as it does not interact with such substances, which will only worsen the situation;
• You should not take Tempalgin if you were administered contrast agents during diagnostic procedures;
• if you take the drug for a long time, be sure to monitor your liver function and blood fluid composition;
• in childhood and adolescence, the duration of “tempalgin” therapy should not exceed 5 days;
• when consuming Tempalgin, drowsiness occurs, concentration of attention decreases, so you should not drive a car or operate machinery;

Organs affected by the toxin

The combined use of pharmacological agents and alcohol has a toxic effect on the internal organs and environments of the body. Alcohol, entering into a chemical reaction with a medicine, leads to poisoning, disrupts physiological processes, enhances or weakens the healing properties of drugs.

The liver suffers more than other organs. She gets hit twice. Many medications have a side effect - hepatotoxicity, destroy cells, and disrupt the physiology of the organ. In the liver, alcohol breaks down to ethanal, a substance 20-30 times more toxic than ethanol, which causes the death of hepatocytes.

Dangerous groups of drugs for the organ in combination with alcohol:

• anti-inflammatory;
• hormonal;
• antibacterial;
• antifungal;
• glucose control agents for diabetes mellitus;
• anti-tuberculosis;
• cytostatics (chemotherapy drugs);
• tranquilizers (anti-epileptic, psychotropic).

In second place among the internal organs exposed to the harmful effects of alcohol together with medications are the heart and vascular system. Strong drinks during drug therapy constrict blood vessels and increase blood pressure. The simultaneous intake of alcohol and chemical substances leads to failure of the myocardium and increases the risk of developing an attack of angina pectoris and a heart attack.

A mixture of ethanol and pharmaceuticals disrupts the quality of the blood and reduces clotting. This is dangerous due to internal bleeding and strokes.

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