Tablets "Tsiprolet"

Category: Published 03/02/2016 · Comments: · Reading time: 4 min · Views: 4,916

"Tsiprolet" is an antibacterial medicine belonging to the group of fluoroquinolones. The agent is highly effective against pathogenic microorganisms. The antibiotic "Tsiprolet" instructions for use prescribes taking it against infectious and inflammatory pathologies that affect various systems of the body.

Composition and release form

The medicine is available in several forms, the optimal one is selected taking into account the type of disease and test results. You can buy at the pharmacy:

Pills. They have a biconvex shape with a film shell, the surface is smooth. The color of the core and outer layer is white, the package contains 1 or 2 blisters of 10 pcs. tablets.
Solution for infusion. Light yellow or colorless transparent liquid. Available with instructions in a cardboard box of 1 bottle of 100 ml.
Eye drops. Light yellow transparent or colorless liquid. Sold in a plastic dropper bottle of 5 ml.

Different dosage forms are designed to treat specific groups of pathologies. Their main medicinal component is ciprofloxacin, which has an antibacterial effect. The composition of the different forms of the medication is as follows:

Type of medicine	Main component	Auxiliary components	Shell composition
Pills	Ciprofloxacin hydrochloride (291.106/582.211 mg)	Magnesium stearate, talc, corn starch, croscarmellose sodium, microcrystalline cellulose, colloidal silicon dioxide.	polysorbate 80, hypromellose (6 cps), macrogol 6000, titanium dioxide, talc, dimethicone, sorbic acid.
Solution for infusion (1 ml)	Ciprofloxacin – 2 mg.	Citric acid monohydrate, sodium hydroxide, lactic acid, hydrochloric acid, sodium chloride disodium edetate, water for injection.
Drops (1 ml)	ciprofloxacin hydrochloride (3.49 mg)	50% solution of benzalkonium chloride, disodium edetate, sodium chloride, hydrochloric acid, water for injection

Pharmakinetics

Suction

Both ciprofloxacin and tinidazole are well absorbed from the gastrointestinal tract after oral administration. Eating slows down absorption, but does not change the maximum concentration or bioavailability.

Distribution

Tinidazole. Bioavailability - 100%, plasma protein binding - 12%, Tmax after oral administration - 2 hours, Cmax after oral administration of 500 mg - 47.7 mcg/ml.

Ciprofloxacin. Bioavailability - 50-85%, Vd - 2-3.5 l/kg, plasma protein binding - 20-40%, Tmax after oral administration - 60-90 min, Cmax after oral administration 500 mg - 0.2 mcg/ ml.

Metabolism and excretion

Tinidazole penetrates the cerebrospinal fluid in a concentration equal to that in plasma and is reabsorbed in the renal tubules. T1/2 - 12-14 hours. Tinidazole is metabolized in the liver with the participation of the cytochrome P450 (CYP3A4) enzyme system. About 50% is excreted in bile, 25% in the kidneys, and 12% in the form of metabolites. It is reabsorbed in the renal tubules.

Ciprofloxacin penetrates well into body fluids and tissues (excluding fat-rich tissue, such as nervous tissue). Concentrations in tissues are 2–12 times higher than in plasma. Therapeutic concentrations are achieved in saliva, tonsils, liver, gall bladder, bile, intestines, abdominal and pelvic organs, uterus, seminal fluid, prostate tissue, endometrium, fallopian tubes and ovaries, kidneys and urinary organs, lung tissue, bronchial secretions, bone tissue, muscles, synovial fluid and articular cartilage, peritoneal fluid, skin. It penetrates into the cerebrospinal fluid in a small amount, where its concentration, in the absence of inflammation of the meninges, is 6–10% of the serum value, and with inflammation - 14–37%. Ciprofloxacin also penetrates well into the ocular fluid, bronchial secretions, pleura, peritoneum, lymph, and through the placenta. The concentration of ciprofloxacin in blood neutrophils is 2–7 times higher than in blood plasma. Activity decreases slightly at pH values less than 6. Metabolized in the liver (15–30%) with the formation of low-active metabolites (diethylciprofloxacin, sulfociprofloxacin, oxociprofloxacin, formylciprofloxacin). T1/2 - about 4 hours. It is excreted mainly by the kidneys by tubular filtration and tubular secretion in unchanged form (40-50%) and in the form of metabolites (15%), the rest - through the gastrointestinal tract. A small amount is excreted in breast milk. Renal Cl - 3–5 ml/min/kg; total Cl - 8–10 ml/min/kg.

In special cases

The pharmacokinetic parameters of tinidazole in patients with chronic renal failure (creatinine Cl above 22 ml/min) do not differ from those in healthy people.

For ciprofloxacin in chronic renal failure, T1/2 increases to 12 hours. In chronic renal failure (creatinine clearance above 20 ml/min), the percentage of the drug excreted through the kidneys decreases, but accumulation in the body does not occur due to a compensatory increase in the metabolism of the drug and its excretion through the gastrointestinal tract.

Pharmacodynamics and pharmacokinetics

The instructions for the drug indicate that Tsiprolet is a broad-spectrum antibacterial medication. The active action is aimed at bacterial enzymes that are involved in DNA synthesis, the product completely suppresses them. The use of the drug is aimed at both bacteria at rest and during the reproduction period. The medicine is good and is quickly absorbed after administration. The percentage concentration approaches the maximum value one and a half hours after application and after 2 hours in the interstitial fluid. The medicine easily penetrates organs and tissues.

According to the instructions, Tsiprolet does not affect bacteria that are not sensitive to methicillin antibiotics. There is no medicinal effect on the pathogens of syphilis, ureaplasmosis, or pathogenic fungi. Microorganisms that are inactive to tetracycline drugs do not show resistance. According to the instructions for the drug, the pathogens are counteracted:

plague;
dysentery;
paratyphoid, typhus;
coli;
pneumonia;
acute intestinal infections;
gonorrhea;
tuberculosis;
brucellosis;
mycoplasmosis;
chlamydia.

pharmachologic effect

Tsiprolet, the instructions for use explains this, helps disrupt DNA synthesis, thereby preventing the growth and reproduction of bacteria.

The product is widely used in the treatment of diseases caused by gram-negative bacteria, including Klebsiella, Shigella, Salmonella, E. coli and others. Some gram-positive bacteria are sensitive to the action of the drug: staphylococci and streptococci.

Tsiprolet is used to treat diseases caused by intracellular organisms: tuberculosis microbacteria, chlamydia and others. The drug is effective against infectious diseases, the development of which was provoked by Pseudomonas aeruginosa.

The drug is not used to treat fungal and viral infections. It is characterized by fairly low activity against anaerobic bacteria and mycoplasmas.

Tsiprolet is well absorbed, due to which the drug is used in the treatment of diseases with intracellular localization of the pathogen. The maximum content of the active substance in the blood is observed after approximately 90 minutes from the moment of administration. The drug is eliminated through the kidneys. The half-life is usually 6-10 hours.

Indications for use of Tsiprolet

Doctors prescribe an infusion solution or tablets for the treatment of infectious and inflammatory pathologies that are caused by bacteria sensitive to ciprofloxacin. Instructions for use of Tsiprolet provide for the use of the drug for the treatment of the following infections:

gastrointestinal tract, jaws, mouth and teeth;
nose, throat, ear;
biliary tract and gallbladder;
respiratory tract;
genital organs (adnexitis, gonorrhea, prostatitis);
postpartum infections;
soft tissues, skin, mucous membranes;
musculoskeletal system;
urinary tract and kidneys;
treatment of peritonitis, sepsis.

The solution and tablets, according to the instructions for use, can be part of complex therapy with immunosuppressants for the treatment and prevention of infections in patients with reduced immunity. Eye drops according to the instructions are prescribed for the treatment of infectious and inflammatory diseases of the eyes and appendages due to damage by bacteria that are sensitive to the drug:

blepharitis, blepharoconjunctivitis;
acute, subacute conjunctivitis;
chronic form of dacryocystitis, meibomitis;
bacterial keratitis, keratoconjunctivitis;
corneal ulcers of bacterial etiology;
infectious complications after surgery;
entry of a foreign body into the eye, infectious complication after injury to the organs of vision;
drops are used for preoperative prophylaxis in ophthalmic surgery.

Instructions for use Tsiprolet 500 mg

The tablets can be taken by adults and children over 15 years of age. How much to prescribe, depending on the specific disease and severity, is indicated by the attending physician. The average dosage for diseases of the respiratory system, ENT organs, gynecological pathology (inflammation of the appendages), complicated infections of the urinary system is considered to be 500 mg twice a day. In severe cases, the dose may be increased to 1.5 g per day. Tablets of 500-700 mg twice a day are also prescribed for intra-abdominal infections. They can also treat the consequences of the flu. The average duration of treatment is 5-7 days. When taking it, you should drink enough water. It is typical that small dosages of the drug can cure cats, and they can be given tablets for kidney disease.

Dosage in adults for sore throat, colds, bronchitis, sinusitis

The average dosage for diseases of the ENT organs (sore throat, colds, sinusitis) in uncomplicated forms is 500-750 mg every 12 hours. Sinusitis can be treated with nasal drops. Initially, Amoxicillin (a group of penicillins) is most often prescribed for angina. For bronchitis, a dose of Tsiprolet is prescribed 250-500 mg per day. As an additional medicine, the antibiotic Amoxiclav, Azithromycin, Nolitsin (fluoroquinolone) can be added - which one to replace or add a second one, the amount - the doctor decides. In parallel, therapy may be prescribed with injections of other medications that prevent the development of complications. Infusion of the drug in question is possible.

During early pregnancy

Tsiprolet is prohibited for use at any stage of pregnancy, as it can provoke pathology of the fetal joints. It can be prescribed only for health reasons if the pregnant woman is in danger of life.

Tsiprolet eye drops instructions for use for children

Children under the age of 12 years can be prescribed in the form of ophthalmic drops, which are instilled into the affected eye, 1-2 drops with an interval of 4 hours. In severe cases, hourly instillation of drops is allowed. The course lasts until the symptoms disappear, on average 5-14 days. Children are also prescribed ear drops.

Directions for use and dosage

The medicine Tsiprolet is prescribed by the attending physician and writes a prescription for it. The dosage, regimen and duration of treatment depend on the type of infection, severity of the disease, body condition, body weight and age of the patient, and kidney function. There are recommendations for use in the instructions, but these are only general rules. Only a doctor will determine the exact course of treatment based on tests and examination results of the patient.

Tsiprolet tablets

According to the instructions, this form of medication is taken orally before meals on an empty stomach, washed down with plenty of liquid. The doctor prescribes individually the duration of treatment and dose based on clinical indications, taking into account the type of infection, age, weight of the patient and the severity of the condition. There is the following standardized dosage regimen according to the instructions for use:

for urinary tract and kidney infections: 2 times a day for uncomplicated form, 250 mg, severe form - 500 mg;
for gonorrhea, take 250 or 500 mg once;
infections of the lower respiratory tract: 2 times a day, 250 mg for moderate severity and 500 mg for severe;
complex course of gynecological infections, colitis, enteritis, prostatitis, osteomyelitis: 2 times 500 mg per day;
for diarrhea, take 250 mg 2 times a day.

On average, the course of treatment lasts 7-10 days until complete recovery, but after the signs of pathology disappear, you need to take the medicine for another 2-3 days. In the presence of severe renal dysfunction, the dosage of the drug is reduced by 2 times. The dose in case of chronic renal failure directly depends on CC (creatinine clearance):

above 50 ml/min – standard dose;
30-50 ml/min – 1 time 250-500 mg at 12 hours;
5-20 ml/min – once every 18 hours, 250-500 mg;
during dialysis, 250-500 mg is prescribed once every 24 hours.

Drops Tsiprolet

This form of medication is used for local treatment by instilling the medication into the conjunctival sac of the infected eye. The recommended dosage according to the instructions is as follows:

for moderately severe, mild infection: 1-2 potassium every 4 hours;
severe form of infection: 2 drops every hour, after the condition begins to improve, the frequency of use and dosage should be reduced;
for a bacterial corneal ulcer, 1 drop is dripped according to the following scheme: 1st day - every 15 minutes for 6 hours, then only during wakefulness every 30 minutes; 2nd day – every hour while awake; Days 3-14 – every 4 hours.

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Solution for infusion

The medicine is used intravenously - intravenous drip. According to the instructions, it is possible to mix Tsiprolete solution with 0.9% sodium chloride, 5%-10% dextrose, 10% fructose, Ringer's solution. When prescribing use, one must take into account the type of infection, clinical indications, weight, age, patient conditions, and concomitant diseases. The infusion duration is 30 minutes for 200 mg of the drug. The following dosages are used:

moderate infections - 200 mg 2 times a day for 7-14 days;
severe infections - 2 times a day, 400 mg for 7014 days;
acute gonorrhea – 100 mg once;
prevention of infections after surgery - 1 hour before surgery, 200-400 mg of Tsiprolet.

Tsiprolet or Amoxiclav

Both drugs are not analogues of each other. Tsiprolet is an antimicrobial drug of the fluoroquinolone group with the active substance - Ciprofloxacin. Release form: eye drops, solution for infusion, film-coated tablets. Amoxiclav is a combined antibiotic of the penicillin group (active ingredients: Amoxicillin and Clavulanic acid). Forms of release of the drug: tablets (coated or soluble), suspension for oral administration, solution for intravenous administration. Amoxiclav is indicated for the following diseases:

infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);
infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
urinary tract infections (eg, pyelonephritis);
gynecological infections;
skin and soft tissue infections, including human and animal bites;
infections of bone and connective tissue;
biliary tract infections (cholecystitis, cholangitis);
odontogenic infections.

For powder for preparing a solution for intravenous administration, additionally:

abdominal infections;
sexually transmitted infections (gonorrhea, chancroid);
prevention of infections after surgery.

Amoxiclav can be used from birth. Tsiprolet is prescribed only from the age of one year (for eye drops). The medications are prescribed by the doctor taking into account the diagnosis!

Amoxiclav is more expensive than Tsiprolet.

Tsiprolet or Amoxiclav. Photo: tempore.ru

special instructions

To avoid the appearance of possible negative reactions from the central nervous system, patients with a history of epilepsy, vascular pathologies, organic brain lesions, according to the instructions, can be prescribed Tsiprolet only for health reasons. If prolonged, severe diarrhea develops during treatment, pseudomembranous colitis should be excluded. If it is confirmed, then the use of the tablets must be immediately discontinued.

There is a risk of inflammation and tendon rupture due to the use of Tsiprolet (solution or tablets). At the first manifestations of pain, tenosynovitis, it is necessary to stop treatment. Parenteral and oral use of the drug must be accompanied by the consumption of a sufficient amount of fluid if normal diuresis is diagnosed. It is recommended to avoid direct sunlight during treatment.

You should not wear contact lenses while treating your eyes with drops. It is forbidden to drip the product subconjunctivally or into the anterior chamber of the eye. If there are other ophthalmic solutions in the treatment regimen, the break between procedures should be at least 5 minutes. During treatment using Tsiprolet, it is not recommended to drive vehicles or machinery.

Interaction

Effects due to tinidazole. Enhances the effect of indirect anticoagulants. To reduce the risk of bleeding, the dose of TsiproletA is reduced by 50%. Enhances the effect of ethanol (disulfiram-like reactions). Phenobarbital accelerates the metabolism of tinidazole. The drug Tsiprolet A is not recommended to be prescribed with ethionamide.

Effects due to ciprofloxacin. Due to a decrease in the activity of microsomal oxidation processes in hepatocytes, it increases the concentration and lengthens T1/2 of theophylline and other xanthines, incl. caffeine, oral hypoglycemic drugs, indirect anticoagulants, helps reduce the prothrombin index. It enhances the nephrotoxic effect of cyclosporine, there is an increase in serum creatinine; in such patients it is necessary to monitor this indicator 2 times a week. Oral administration together with iron-containing drugs, sucralfate and antacid drugs containing Mg2+, Ca2+, Al3+, didanosine leads to a decrease in the absorption of ciprofloxacin. Therefore, the drug CiproletA is prescribed 1–2 hours before or 4 hours after taking the above drugs. NSAIDs (excluding acetylsalicylic acid) increase the risk of seizures. Metoclopramide accelerates absorption, which leads to a decrease in Tmax. Co-administration of uricosuric drugs leads to a slower elimination (up to 50%) and an increase in plasma concentrations of ciprofloxacin. Increases Cmax by 7 times (from 4 to 21 times) and AUC of tizanidine, which increases the risk of a pronounced decrease in blood pressure and drowsiness.

The drug TsiproletA is compatible with sulfonamides and antibiotics (β-lactam antibiotics, aminoglycosides, erythromycin, rifampicin, cephalosporins), when combined with which synergism is usually observed.

Drug interactions

The treatment regimen is drawn up by the doctor, taking into account all factors, including compatibility with other medications. It should be taken into account that when taking Tsiprolet simultaneously:

The concentration of theophylline in the blood plasma may increase, increasing the risk of toxic effects;
didanosine reduces the absorption of cirpofloxacin;
drugs containing zinc, aluminum, magnesium, iron and antacids can reduce the absorption of ciprofloxacin; it is necessary to maintain a pause of 4 hours between doses of these drugs;
NSAIDs (except acetylsalicylic acid) increase the likelihood of seizures;
cyclosporine increases nephrotoxic effect;
other antimicrobial medications (metronidazole, clindamycin, beta-lactams, aminoglycosides) provoke synergistic action;
uricosuric drugs increase plasma concentrations of ciprofloxacin;
absorption of ciprofloxacin is accelerated by metoclopramide;
the effect is enhanced and the bleeding time of indirect anticoagulants increases.

To treat individual pathologies, combinations of agents that positively complement each other can be used, for example:

infections caused by Pseudomonas spp: ceftazidime, azlocillin;
staphylococcal pathologies: vancomycin, isoxazolylpenicillins;
streptococcal infections: beta-lactam antibiotics, azlocillin, mezlocillin;
anaerobic infections: clindamycin, metronidazole
.

Pharmadynamics

A combined drug whose effect is determined by the components included in its composition.

Tinidazole is an antiprotozoal and antimicrobial agent, an imidazole, effective against Trichomonas vaginalis, Entamoeba Histolytica, Lamblia, as well as pathogens of anaerobic infections (Clostridium spp., Bacteroides Fragilis, Bacteroides melaninogenicus. Eubacter spp., Fusobacterium spp., Peptococcus spp. And PeptostReptococcus spp.). Being a highly lipophilic drug, it penetrates into Trichomonas and anaerobic microorganisms, where it is reduced by nitroreductase, inhibits synthesis and damages the DNA structure.

Ciprofloxacin is a broad-spectrum antimicrobial agent, a fluoroquinolone derivative, that inhibits bacterial DNA gyrase (topoisomerases II and IV, responsible for the process of supercoiling of chromosomal DNA around nuclear RNA, which is necessary for reading genetic information), disrupts DNA synthesis, growth and division of bacteria; causes pronounced morphological changes (including cell wall and membranes) and rapid death of the bacterial cell.

It has a bactericidal effect on gram-negative organisms during the period of rest and division (since it affects not only DNA gyrase, but also causes lysis of the cell wall), on gram-positive microorganisms - only during the period of division. Low toxicity for the cells of the macroorganism is explained by the absence of DNA gyrase in them. While taking ciprofloxacin, there is no parallel development of resistance to other antibiotics that do not belong to the group of gyrase inhibitors, which makes it highly effective against bacteria resistant to aminoglycosides, penicillins, cephalosporins, tetracyclines and many other antibiotics.

Gram-negative aerobic bacteria are sensitive to ciprofloxacin: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp. , Morganella morganii, Vibrio spp., Yersinia spp.), other gram-negative bacteria (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), some intracellular pathogens (Legionella pneumophila, Brucella spp., Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii); gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).

Most staphylococci resistant to methicillin are also resistant to ciprofloxacin. Resistance develops extremely slowly, since, on the one hand, after the action of ciprofloxacin there are practically no persistent microorganisms left, and on the other hand, bacterial cells do not have enzymes that inactivate it. The following are resistant to the drug: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Ineffective against Treponema pallidum.

Side effects of Tsiprolet

If the rules of use according to the instructions, dosage and drug compatibility are violated, negative reactions may occur from different systems of the body. Solution for infusion, film-coated tablets may cause the following side effects:

Nervous system: tremor, increased fatigue, dizziness, headache, nightmares, anxiety, insomnia, increased intracranial pressure, sweating, peripheral paralgesia, hallucinations, confusion, depression and other psychotic reactions, cerebral artery thrombosis, migraine, fainting;
Sense organs: changes in color perception, impaired taste, smell, tinnitus, hearing loss, diplopia;
Digestive system: flatulence, diarrhea, vomiting, nausea, abdominal pain, hepatitis, anorexia, cholestatic jaundice (if there is a history of liver pathologies), increased activity of alkaline phosphatase, liver enzymes, hepatonecrosis;
Cardiovascular system: flushes of blood to the skin of the face, tachycardia, heart rhythm disturbances, decreased blood pressure;
Hematopoietic system: thrombocytosis, hemolytic anemia, leukocytosis, thrombocytopenia, granulocytopenia, leukopenia, anemia;
Urinary system: interstitial nephritis, polyuria, decreased nitrogen excretory function of the kidneys, urethral bleeding, dysuria, hematuria, albuminuria, glomerulonephritis, crystalluria, urinary retention.
Musculoskeletal system: tendon rupture, myalgia, tenosynovitis, arthralgia, arthritis.
Laboratory indicators: hyperglycemia, hypoprothrombinemia, hyperbilirubinemia, hypercreatininemia.
Allergic reactions: urticaria, shortness of breath, itching, swelling of the larynx and face, eosinophilia, fever, vasculitis, petechiae, increased photosensitivity, Stevens-Johnson syndrome, erythema nodosum, Lyell's syndrome, exudative erythema multiforme, the appearance of blisters with bleeding, the formation of nodules that form scabs .
Other: general weakness, superinfections (candidiasis, pseudomembranous colitis).

In addition to the above reactions, when using the solution for infusion, a burning sensation, pain at the injection site, and phlebitis may occur. The following side effects are possible when using eye drops:

Visual organs: itching, conjunctival hyperemia, mild pain, burning. Rarely, lacrimation, photophobia, foreign body sensation in the eyes, swelling of the eyelids, corneal infiltration, decreased visual acuity, keratopathy, and keratitis occur. In patients with corneal ulcers, a white crystalline precipitate may appear.
Other: allergic reaction, nausea, rarely develops a feeling of unpleasant taste in the mouth, superinfection.

Side effects

In certain cases, the following undesirable reactions of the body are noted:

tachycardia, migraine and fainting;
nausea, vomiting, diarrhea, dysfunction of the gastrointestinal tract, unbearable pain in the abdomen, bloating, lack of appetite;
dizziness, headache, insomnia, lack of sleep, sweating, lack of coordination, convulsions, persistent feelings of fear, nightmares at night, depression, hallucinations, visual disturbances and tinnitus;
thrombocytopenia, extremely rarely - leukocytosis, thrombocytosis, hemolytic anemia;
skin rashes, itching, anaphylactic shock, nephritis, hepatitis.

In case of particularly acute reactions of the body to the active substance of the drug, you should stop taking it. If this is not done, you may face more dangerous and unforeseen consequences.

Overdose

It is important to follow the rules for using the medication prescribed by your doctor or instructions. If adverse reactions develop due to exceeding the dosage, it is recommended to perform the following therapeutic actions:

ensure monitoring of the patient's condition;
perform gastric lavage;
carry out standard emergency measures;
ensure the supply of the required amount of fluid;
in the hospital, using peritoneal and hemodialysis, remove the remaining drug.

Analogues of Tsiprolet

Maxitrol drops
are a dual-action drug. It actively reduces swelling, eliminates redness syndrome and pain in the affected area, and has an antimicrobial effect. The drug is produced on the basis of three active ingredients (neomycin, dexamethasone, polymexin B), which makes it effective in the fight not only against microorganisms, but also against the original source of infection. Eye drops may have a minor effect on your ability to drive. After use, you must wait until your vision clears. Due to the lack of clinical data, it is not recommended to use Maxitrol during pregnancy and breastfeeding, and in children in the first year of life. Drops are dispensed in pharmacies only with a prescription from the attending physician.
Tobrex
is a drug with a combined effect that has an antibacterial and anti-inflammatory effect. The active ingredients are tobramycin and dexamethasone. The drops have no age limit; they can be used by children from birth. During pregnancy and during the lactation period, the use of the product is not recommended. If blurred vision appears after instillation, you must wait until it recovers. Tobrex does not affect the reaction speed, therefore it is allowed to drive vehicles. Dispensing in a pharmacy is only available with a doctor's prescription.
The medicinal solution " Tsipromed
" is used for diseases with inflammatory processes in the anterior eye chamber. The composition contains the active ingredient - ciprofloxacin, and other additional components that ensure long-term storage and effectiveness of treatment. During instillation of the drug, minor visual disturbances may occur. You must wait until it is restored, after which you are allowed to drive vehicles. The use of Tsipromed during pregnancy and lactation is not recommended. Children can use the product from the age of 1 year. Dispensing in a pharmacy is carried out only with a prescription from the attending physician.
Garazon
is an eye drop used in ophthalmology to treat bacterial infections of the eyes and ears. The drug contains gentamicin and betamethasone. An antibiotic in combination with a hormonal component has an antimicrobial and anti-inflammatory effect. Drops are used to treat diseases of the anterior segment of the eyes. Garazon is not recommended for use during pregnancy and lactation. Clinical data on the safety of use in children under 12 years of age have not been established. You can purchase the drug in a pharmacy only with a doctor's prescription.

Contraindications

It is necessary to prescribe Tsiprolet with caution in case of cerebral atherosclerosis, convulsive syndrome, and cerebrovascular accident. Absolute contraindications for any form of medication:

hypersensitivity to the components of the drug.
period of pregnancy, breastfeeding;
individual hypersensitivity to drugs of the fluoroquinolone group.

There are separate contraindications for different dosage forms of the drug. Film-coated tablets and solution for infusion are not prescribed:

patients under 18 years of age;
in the presence of pseudomembranous colitis.

The drug should be prescribed with caution to patients with mental pathologies, the elderly, those with severe liver or kidney failure, or epilepsy. Eye drops are contraindicated for:

viral keratitis;
under 1 year of age.

Compound

Ciprofloxacin hydrochloride in terms of ciprofloxacin 3 mg is the active ingredient of Tsiprolet drops. This is a compound related to fluoroquinolone derivative antibiotics.

Sodium chloride 9 mg, hydrochloric acid 0.000034 mg, disodium edetate 0.5 mg, benzalkonium chloride solution 50.0% are auxiliary components.

In order for the drug to maintain its effectiveness for a long time and not deteriorate, the composition includes excipients.

Analogs

If necessary, the doctor can prescribe a structural analogue of Tsiprolet. Popular options include the following medications:

Ciprofloxacin-AKOS;
Rocip;
Tsipromed;
Quintor;
Ciprobid;
Ificipro;
Ciprobay;
Cyprinol;
Tsifran;
Ciprofloxacin

Reviews

Olga:

“Tsiprolet is an effective antimicrobial agent with a wide spectrum of action. The advantages of the drug are its low cost, ease of use, and the absence of allergic reactions. The only disadvantage is the presence of contraindications. The drops helped me noticeably after just two days, the pain decreased and the redness went away a little. I took a course as prescribed by the doctor. For six months I have no longer been bothered by inflammatory processes in the eyes.”

Natalia:

“My daughter often has health problems due to attending kindergarten. And against the background of respiratory diseases, a complication in the form of conjunctivitis often occurs. Sharp pain and redness appears. After the doctor prescribed Tsiprolet drops, relief came on the second day. After a few days, the conjunctivitis went away. Now I always keep this product in my medicine cabinet. I was pleased with the low cost, which I consider a big advantage of the drug.”

Ksenia:

“In the winter season, health problems appear in our family. Due to the constant cold, colds often occur, which are accompanied by infectious eye diseases. Recently I have been experiencing pain and redness in my eyes. They were constantly watering, and tea leaves were no longer helping. After going to the doctor, I was prescribed the drug “Tsiprolet”. The doctor wrote out a prescription and sent it to the pharmacy. I was pleasantly pleased with its price. At the nearest pharmacy it was sold for 57 rubles. After a few days, relief came, the redness and pain noticeably went away. I didn't find any shortcomings. There were no allergies to components or blurred vision.”

Maria:

“My eyes started to water a lot. Later they turned red and there was a cutting pain. One eye had white crusts and an unpleasant foreign body sensation. At the pharmacy, on the doctor’s recommendation, I purchased Tsiprolet drops and began instilling them into both eyes at once. Improvement occurred immediately and symptoms eased. The product does not sting the eyes and helps well from the first days of the disease. All symptoms disappeared after 4 days. I was treated according to the regimen as prescribed by the doctor. After a month nothing bothers me. The drug has an antibacterial effect with a wide spectrum of action. At the pharmacy its cost was 80 rubles.”

Tsiprolet price

You can buy the product through an online pharmacy or at a regular dealership. The cost depends on the region of sale and the manufacturer. The approximate price for Tsiprolet in Moscow is as follows:

Place of sale	Release form	Cost, rubles
ZdravZona	Tsiprolet 250	46
WER.RU	Tsiprolet 500	112
ZdravZona	Tsiprolet A	177
"Dialogue"	eye drops 5 ml	45
"Dialogue"	Tsiprolet 500	78
"Dialogue"	Tsiprolet A	158

What is hidden behind the definition of antibiotics?

They have been known since the beginning of the last century, when Penicillin was first discovered and quite successfully used in practice.
It was from that very moment that the entire vast industry for the production of antibiotic drugs began to develop.

Around the mid-twentieth century, synthetic antimicrobial drugs in the quinolone category were created. In addition to a high degree of effectiveness, they had a large number of side effects.

A little later, around the mid-eighties of the last century, fluorine was added to the drug formula to reduce the large number of undesirable effects from their use and increase the range of effects. This is how fluoroquinolones were obtained, to which Tsiprolet is classified.

Drug Tsiprolet 500

It is important to be able to distinguish between such different concepts as antibiotics and antibacterial compounds. The latter is a generalized name for a group of medications that have antimicrobial activity, which also includes antibiotics and antimicrobial drugs

But as for substances that inhibit the growth of living organisms, they are exclusively of natural origin (like the well-known Penicillin). Drugs that are used to fight microbes are synthesized artificially from certain compounds and have no analogues in nature (for example, fluoroquinolones).

About the treatment of sinusitis

Treatment of sinusitis is prescribed depending on the nature of its occurrence and the degree of neglect of the process. In most cases, drug therapy is used. The treatment regimen is developed individually and depends on the type of sinusitis and the causes that caused it.

For example, sinusitis of viral etiology can be cured without antibiotic therapy.

In this case, antihistamines, immunomodulators and vasoconstrictors are used.

If a bacterial infection occurs, the use of antibiotics is required.

At the moment, there are more than enough of them for the treatment of sinusitis. One of them is Tsiprolet.

Before starting systemic treatment, it is necessary to make sure that the disease is of a bacteriological nature.

The main symptoms of the disease are accompanied by purulent inflammation, nasal discharge and fever. Many patients experience severe headaches accompanied by intoxication of the body. That is why the treatment of this type of pathology requires a thorough approach.

Interaction with other medications

If during the course of therapy it is necessary to use any other ophthalmic agents, then a mutual strengthening of the influence will occur.

This is especially true in parallel use with Azlocillin and Ceftazidime. A similar course is often prescribed in case of damage to the visual organs by streptococcus. When the causative agent of the disease is staphylococcus, then Tsiprolet is combined with Vancomycin and Isoxazolepenicillin. In case of eye damage with an anaerobic infection, the drug in question is prescribed together with Clindamycin and Metronidazole.

Analogues of Tsiprolet drops, their prices

Today there are more than a dozen names of drugs created on the basis of ciprofloxacin.

In addition, the pharmacological industry produces analogues: Levomecetin, Sulfacyl sodium, Tobrex, Normax, Oftaquix. These drugs have antimicrobial properties similar to those of Tsiprolet.

Jackson's corticosteroid eye drops cannot be classified as analogues of this drug. Since they have a different mechanism of action.

It should be noted that this drug is sold by pharmacies with a prescription, their average price is 65 rubles. This is the lower line of the average price category for drugs of this type.

Very important! Use the medicine as prescribed by the doctor. All bottles are packed in cardboard boxes

Instructions for use located inside are required reading.

All bottles are packed in cardboard boxes. Instructions for use located inside are required reading.

The content of all content presented on the site is for educational and informational purposes only, aimed at giving visitors to the resource a clearer idea of healthy vision, its acquisition and maintenance, diagnosis, prevention and treatment methods and techniques.

Main properties of the medicine

Ciprofloxacin is a broad-spectrum antibiotic. It is capable of inhibiting the activity of certain enzymes, thereby disrupting the processes of protein synthesis in the bacterial cell and, accordingly, making their further reproduction impossible. This medicine is active against most pathogenic bacterial microorganisms, including streptococci, chlamydia, E. coli, staphylococci, Proteus, Listeria, etc. But the medicine is not active against viral and fungal organisms. The antibiotic also does not act on Treponema pallidum, Clostridia and Ureaplasma.

Characteristics of Ciprofloxacin

The drug belongs to the category of antibacterial agents. It is a first generation drug and is considered a fluoroquinolone. The active ingredient is ciprofloxacin hydrochloride. Available in ear and eye drops, solution for infusion, tablets and ophthalmic ointment.

Exhibits a bactericidal effect. Used for hospital infections. The active substance penetrates cellular structures and tissues. The mechanism of action is the inhibition of the enzyme of bacterial cells with disruption of DNA synthesis, division and reproduction of microbes.

Effective for diseases that arise from the activation of staphylococci, enterococci, legionella, mycoplasma, chlamydia and mycobacteria. Characterized by activity against beta-lactamases.

Reviews from doctors about Tsifran and Tsiprolet

Alexey, dentist: “I prescribe Tsiprolet to patients who have inflammatory processes in the tooth (chronic periodontitis). The medicine has few contraindications and side effects, and practically does not cause allergic reactions.”

Dmitry, infectious disease specialist: “In my practice, I often prescribe Tsiprolet for bacterial eye diseases, since this drug has a wide spectrum of bactericidal effects. It rarely causes allergic reactions."

Oksana, dermatovenerologist: “I often prescribe the antibiotic Tsifran in my practice for the treatment of venereological and dermatological diseases. It effectively destroys many microorganisms and has a minimum of contraindications.”

Treatment of bacterial sinusitis

Since bacteria predominantly enter the sinuses by contact or aerosol methods, purulent sinusitis develops especially often in patients of the younger age category. Since the risk of foreign bodies getting into the sinuses in children (due to elementary curiosity) is much higher than in adults. Also, purulent maxillary sinusitis can develop due to pathological processes in the oral cavity, in particular periodontitis. In this case, odontogenic sinusitis is diagnosed.

It should be remembered that depending on the form of the disease, the symptoms of sinusitis can manifest themselves with varying degrees of intensity. In acute pathologies of the maxillary sinuses, the manifestations are pronounced, and the patient’s clinical picture worsens over a short period of time. With chronic purulent sinusitis, the symptoms may be blurred and not appear for a long period.

For this reason, the diagnosis of sinusitis should be carried out by a qualified otolaryngologist, based on a visual examination and laboratory testing of biomaterial from the paranasal sinuses. Only in this case can we guarantee effective treatment and prevent the development of possible complications, including: orbital abscesses, perforation of cartilage tissue, meningitis, and various systemic diseases.

Comparison of Ciprofloxacin and Ciprolet

Both medications are based on the same active substance, so their chemical composition is identical.

Similarities

Both drugs have the same effect on pathogenic microbes: they stop protein synthesis and block the cell division mechanism. The drugs are especially effective against the following pathogens:

staphylococci:
streptococci;
listeria;
coli;
enterobacteria;
chlamydia.

The list of contraindications for Ciprofloxacin and Ciprolet is the same.

The medications exhibit the same activity against the causative agent of tuberculosis and can be used when this disease is combined with other types of infection. If one of the drugs turns out to be ineffective against any microorganism, then there is no point in prescribing another drug in this case. The list of contraindications for the drugs is the same. With the exception of a negative reaction to the medication associated with individual intolerance, both drugs do not have a significant toxic effect on the body.

What is the difference?

The difference between the drugs lies in different manufacturing countries. Unlike the Russian product, the Indian Tsiprolet is better purified from impurities, so adverse events after its use are observed less frequently. When using Ciprofloxacin, increased heart rate, arrhythmia, drop in blood pressure, muscle pain, and tendon rupture are somewhat more common.

Which is cheaper?

The price of Russian-made Ciprofloxacin is 37-43 rubles (depending on the manufacturer) for 10 tablets of 500 mg, 19-20 rubles for 10 tablets of 250 mg. The cost of Indian Tsiprolet is 103 (500 mg) and 64 rubles (250 mg). The domestic drug costs almost 3 times less.

How to distinguish viral sinusitis from purulent maxillary sinusitis

Unlike the catarrhal form of pathology of the paranasal sinuses, bacterial sinusitis is dangerous due to multiple complications. Therefore, a timely and correct diagnosis is the key to short but effective treatment.

Both catarrhal and purulent sinusitis have a number of similar symptoms, including:

violation of nasal respiration;
the presence of pain in the projection of the maxillary sinuses;
temperature rise to febrile levels;
the presence of secretory mucous discharge (in the absence of obstruction of the paranasal sinus anastomosis);
swelling of the skin over the maxillary sinuses;
the presence of pain that loses its specific location;
decreased sense of smell and impaired phonation;
phenomena of general intoxication of the body (chills, aching joints, sleep disturbances, headaches, lack of appetite, and so on).

Given the similarity of symptoms of viral and bacterial sinusitis, only a qualified specialist can make a correct diagnosis. However, even with a visual examination of mucous secretions, preliminary conclusions can be drawn about the nature of the infectious agent. With viral infections of the paranasal sinuses, the discharge is clear, without any coloration. In purulent forms of maxillary sinusitis, the color of the secretory discharge varies from yellow to dark green.

Use for otitis media

What else does the Tsiprolet instruction tell us?

Ear drops are widely used in the practice of otolaryngologists for the treatment of otitis media. As a rule, they are prescribed if other antibacterial substances are ineffective. The solution for instillation is sterile, which allows it to be instilled into the ears as prescribed by a doctor. Tsiprolet ear drops are prescribed for the treatment of otitis media of the middle ear and external type, as well as complications of an inflammatory and infectious nature during the recovery period after surgery.

When prescribing a drug for the treatment of otitis, you should take into account the fact that Tsiprolet ear drops have certain contraindications. The dosage is determined by the doctor depending on the form and course of the pathological process

The duration of use is also prescribed by a specialist.

For mild otitis, 1-2 Tsiprolet ear drops are instilled into the affected ear, and the procedure is repeated every four hours. In the case of an acute course, the interval between instillation should be one hour until positive dynamics and improvement in the patient’s condition occur. Next, the treatment is adjusted. The duration of therapy is 7-10 days, but in exceptional cases the specialist may decide to prolong treatment up to one month.

In childhood, the dosage and frequency of use of Tsiprolet ear drops is also determined by the doctor depending on the nature and form of the pathological process. It is not recommended to complete treatment on your own, as this may affect the child’s immune system. The course must be completed in full, strictly as prescribed by the doctor.

Additional recommendations for using the product

According to the instructions, Tsiprolet drops are strictly contraindicated for administration to patients into the anterior ocular chamber. The drug is not suitable for injections under the mucous membrane of the eye and is intended only for local use. In cases where "Tsiprolet" is used in conjunction with any other medications, at least five to ten minutes must pass between instillation of different drugs.

During therapy, patients are not recommended to use contact lenses; the fact is that such optics can cause eye irritation. If, after the first use, patients experience excessive lacrimation, then under no circumstances should you stop the treatment course, because this is a temporary effect. Immediately after the instillation procedure, it is necessary to refrain from heavy physical activity for some time, and also not to engage in any activity that requires increased attention and concentration of vision (for example, we are talking about small work and activities at the computer).

During treatment with Tsiprolet, it is imperative to try to avoid direct contact of the tip of the medicinal bottle with various surfaces that may contain microorganisms that can provoke the occurrence of additional ophthalmological pathologies. The drug is dispensed in pharmacies strictly according to a doctor's prescription.

Reception scheme

Instructions for use contain recommendations for proper use and acceptable daily allowances. Rules to follow when taking antibiotics:

observe a 12-hour interval between taking pills;
take the antibiotic with plenty of drinking water;
Do not combine taking pills with meals;
give up dairy products, they reduce the effect of the medicine;
Do not go to the solarium or the beach; photosensitivity may develop in the sun.

Adults

For elderly people, Tsiprolet is prescribed with caution. This category of patients is more likely to have side effects. For moderate sinusitis, adult patients are prescribed tablets according to the regimen of 250 mg per day. Course duration is from 5 to 7 days. If the course of the disease is complicated, the doctor increases the daily dose to 500 mg. In this case, the patient takes tablets 2 times a day. The dose of medication for a single dose is 250 mg.

Tsiprolet is not prescribed to children and adolescents. The active substance included in the tablets can have a negative effect on the growing body, it can provoke tendon rupture. Doctors prescribe the medicine Tsiprolet for sinusitis in patients over 18 years of age.

Tsiprolet is not prescribed to women carrying a child. The stage of pregnancy does not matter. The placenta does not prevent the penetration of ciprofloxacin into the fetus, this can lead to serious consequences.

The concentration of the antibiotic in breast milk is high, so during the treatment of sinusitis in the mother, the child is weaned from breastfeeding. Resume feeding the baby with breast milk after completely clearing the body of ciprofloxacin. Cleaning takes at least 7 days.

Tsifran: analogues and comparative characteristics of drugs

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Amoxiclav or Tsifran: which is better?

It is worth understanding the following question: Amoxiclav or Cifran, which is better? Comparative characteristics of the therapeutic effect of Amoxiclav and Tsifran indicate that:

Amoxiclav is a combined antibacterial drug, available not only in the form of tablets, but also as a suspension. It contains clavulanic acid, so treatment with this drug is easier to tolerate by the patient’s body.
However, Cifran is the only oral drug with antipseudomonas activity. Therefore, it is more effective in treating acute forms of infectious diseases and advanced bacterial infections.
We also note that Cifran demonstrates high effectiveness for the treatment of elderly patients.

If you perform a comparative description of another analogue of Tsifran in terms of therapeutic effect, you can come to the following conclusions: Tsiprolet is available in the form of tablets, injection solution and eye drops.

Both drugs are antibiotics used to treat various types of infections, however, Tsiprolet belongs to the second generation antibiotics and is better tolerated by patients with gastrointestinal problems.

This drug is prescribed to combat infectious and bacterial diseases.

Cifran is best taken by those patients who suffer from gastrointestinal diseases. After all, Cifran ST has virtually no effect on the microflora in the human intestine, thereby not provoking bacterial candidiasis and vaginal vaginosis in representatives of the fairer sex of humanity.

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Dysbacteriosis does not develop while taking it, but the effectiveness of treatment is quite high. The effect lasts for 12 hours after taking the tablet.

Cifran and Ciprofloxacin have exactly the same effect on the human body. These drugs are interchangeable, that is, if it is impossible to get one of them, it can be replaced with an analogue. Both drugs are highly effective in combating many diseases. For example, they are used in the treatment of chronic sinusitis or sinusitis.

Both Cifran and Ciprofloxacin are used in the treatment of adult patients. They are not prescribed for children under 6 years of age; the course of treatment is selected individually for each specific patient and can be adjusted during the admission process.

Tsifran and Tsifran ST: differences in drugs in therapeutic action and composition

Tsifran ST is a combination drug made on the basis of tinidazole.

The product is characterized by antiprotozoal and antibacterial properties.

This is an antibiotic that effectively eliminates gram-positive and gram-negative anaerobic microorganisms.

Tsifran and Tsifran ST are very similar in composition and effect on the patient.

However, they also have their differences: the latter is used in cases of illness caused specifically by gram-negative bacteria and demonstrates a wider spectrum of action.

Medicines for ureaplasma are medications that treat opportunistic microorganisms in the reproductive system. Ureaplasmosis is often detected together with chlamydia or mycoplasmosis. Infection occurs during sexual intercourse or when the fetus passes through the birth canal. As treatment for infection, doctors will suggest the use of medications for ureaplasma such as antibiotics, suppositories, immunostimulating drugs and others.

When is it time to treat

Bacteria are divided into several subspecies; doctors count about seven of them, and only two of them negatively affect the body. They begin to actively reproduce at moments when a person is weakened (stress, the presence of diseases in the chronic stage; a course of hormone therapy; pregnancy; STDs; the presence of urethritis).

The clinical picture of ureaplasmosis is as follows:

Transparent discharge from the genitals;
Burning and cutting pain when urinating;
Dull pain in the lower abdomen;
Temperature increase.

Two partners need to be treated for its manifestations at once, and during the period of preparation for conception they should be tested for the presence or absence of these microorganisms. If you do not pay attention to the presence of the disease, this can lead to an ectopic pregnancy or the threat of miscarriage. What medications are used to treat men and women?

Treatment regimen

After all the tests have been carried out, the doctor prescribes medications with an antimicrobial effect. The next stage is the restoration of immunity with medications. If there are disturbances in the intestinal flora, then its normalization is necessary. The same must be done with the vaginal microflora.

During treatment, partners need a period of abstinence from sexual intercourse. For women, doctors recommend local treatment with suppositories. During treatment for ureaplasma, the patient must avoid alcoholic beverages.

Course of antibiotics

What means are used? Antibiotics are effective medicines for treating infection. Bacteria cannot be destroyed by medications of the penicillin or cephalosporin group.

How to treat ureaplasma? For therapy, drugs from the group of tetracycline, lincosamide, streptogramin, etc. are used. They relieve the inflammatory process, improve the body's defenses, and restore microflora. So, ureaplasma in men is treated.

Tsiprolet. This drug is not addictive. They do not destroy the microflora of the gastrointestinal tract and do not provoke the development of candidiasis. Prevents ureaplasma parvum and its other species from reproducing. Prohibited for nursing mothers; pregnant women; teenagers under 15 years of age. May cause dizziness, migraines, allergies. The patient feels hot flashes. Course of treatment: 5 days, 250 mg. If the amount of ureaplasma is critical, then the dosage can be doubled and the course of treatment lasts 10 days.
Azithromycin. This drug should be taken once every 24 hours. It can be combined with medications to boost immunity and probiotics. Course of treatment: 5 days, 1 thousand mg; break for five days; one day, take 1 thousand mg; break for five days. The course of treatment ends on the 16th day, the patient should take a dosage of 1 thousand mg. Do not take during pregnancy or lactation; if the patient has arrhythmia; allergic reactions. An overdose can lead to hearing problems, vomiting and nausea. Side effects: allergies, candidiasis, allergies, etc.

Doxycycline. A medicine that relieves inflammation of the mucous membranes. Release form: injections and capsules. Course of treatment: dose 200 mg, gradually reduced to 100 mg. Its duration varies from 1 to 2 weeks. Do not take if you have kidney disease, intolerance to tetracycline drugs, or during pregnancy and lactation. When consumed, blood pressure may decrease, vision and gastrointestinal problems may occur, heart palpitations may occur, and allergies may occur.

Auxiliary medications

If the patient has good immunity, then he practically does not suffer from ureaplasmosis. And if the body’s defenses are reduced, then microorganisms often multiply quickly. Therefore, treatment of ureaplasma in men should include taking immunostimulating drugs.

Immunomodulators are often used for treatment, for example, Ureaplasma Immunu. It should be injected intramuscularly to improve immunity several times a day. In men, treatment for infection should be comprehensive. If the patient is taking antibiotics, then his treatment should be combined with antifungal drugs, for example, Nystatin. It prevents fungi and other microorganisms from developing.

Candles

How to treat ureaplasma in women if antibiotics fail? Doctors recommend using suppositories. Their indications: colpitis, candidiasis, chlamydia, mycoplasmosis, ureaplasma parvum. In some cases, doctors prescribe suppositories instead of a course of antibiotics.

Terzhinan. This is a medicine for vaginal administration that relieves inflammation and kills bacteria. It has an antifungal effect. At the same time, these suppositories do not allow Candida fungi to multiply. Treatment of ureaplasma in women is 10 days; if necessary, the doctor can extend the treatment. They are not used to treat children under 16 years of age or people who are allergic to the active components of the drug. You cannot treat ureaplasma with suppositories at the beginning of pregnancy.

Hexicon. These suppositories are used for treatment and preventive measures. They can be used during pregnancy, they prevent the development of harmful microorganisms and reduce the inflammatory process. They do not eliminate the disease completely, but after treatment with them, the bacteria remain in the blood. Their number becomes smaller and the child is no longer infected. After childbirth, treatment can be continued. The course of treatment lasts from 10 to 14 days, the patient is given one suppository at night. If the inflammatory process is very strong, then two suppositories can be administered per day.
Polygynax. This is a universal drug that is prescribed to women for treatment of ureaplasma. It has a bactericidal effect, destroys fungus, eliminates itching and swelling of tissues. It is used during the second and third trimester of pregnancy, but only as prescribed by the attending physician. Course of treatment: 12 days. The patient administers one capsule before bedtime. It is prohibited to use the drug during lactation, in case of individual intolerance, or in early pregnancy.

Why is ureaplasma parvum dangerous?

The greatest danger from infection with microorganisms is during pregnancy. Therefore, gynecologists suggest either treating it during pregnancy or before conception. Ureaplasma parvum can provoke miscarriages and cause premature birth. In some cases, ureaplasma parvum during premature birth affects the uterine cavity, which negatively affects the fetus, infecting the child.

It is worth remembering that it is important to diagnose the disease in time by passing tests. After all, the mother may not show any signs of ureaplasma parvum, but she is often a carrier of the infection. Timely treatment will help not only save the child from infection, but also avoid complications after childbirth.

Properties

As the instructions for use for “Tsiprolet” (500 mg) indicate, the active component is ciprofloxacin, which is included in the category of fluoroquinolones. This substance has the following properties:

Detrimental effects on various types of microbes.
Easy penetration into tissues and cells in the human body.
No habituation of pathogenic bacteria even with long-term use.
No quantitative or qualitative harm to intestinal or vaginal microflora.

These are the main properties inherent in Tsiprolet. When the active substance penetrates the bacterial cell, it stops the production of enzymes that are involved in the process of reproduction of infectious agents, which ultimately leads to the death of microbes.

In accordance with the instructions for use, “Tsiprolet” has a wide spectrum of action, so it is prescribed for the treatment of a wide variety of diseases. Only a limited number of bacteria are capable of showing resistance to its active substance. In most cases, Tsiprolet is prescribed at the initial stage of the disease or if other drugs have not given the expected therapeutic effect.

Today there are four generations of fluoroquinolones, and Tsiprolet is part of the second of them. It fights pathogenic bacteria with a pronounced effect, namely staphylococci, E. coli, streptococci, etc. The drug is absorbed quite quickly and well in the intestines, then entering the bloodstream, then spreading through tissues, bones and organs.

The drug is excreted mainly in urine, and the remainder in bile and feces. The price of the drug is affordable, and it is quite effective, so it is often prescribed by patients independently. However, this is the wrong decision, since the infectious agent may be resistant to the active substance of Tsiprolet. In addition, the drug has a number of contraindications, so some groups of patients should not take it.

Natural methods to fight colds

For the disease to progress quickly and without complications, it is not necessary to take a large number of medications. It is enough to notice the malaise in time and help your body cope with it:

Runny nose child treatment

maintain bed rest,
regularly ventilate the room and humidify the air to 50–70%,
drink plenty of warm, but not hot, liquids,
eat foods that are easy to digest and rich in vitamins.

Effective remedies for runny nose and cough are inhalations based on essential oils or boiled potatoes. You can breathe beneficial vapors over the pan, covered with a towel, or use a special apparatus. The first option is contraindicated for people suffering from hypertension. To improve the condition, inhalations should be carried out 1-2 times a day for at least 5 minutes.

It is useful to consume foods containing phytoncides - onions, garlic, ginger root. They can also be cut up and simply placed in the patient’s room. The volatile substances of these products disinfect the air.

At the first symptoms of malaise, while the temperature is still within normal limits, you can carry out warming procedures - put on mustard plasters, steam your feet or take a bath, stick pepper plaster on your feet. To treat rhinitis, you should warm up your sinuses as often as possible.

You can fight a cold with the following folk remedies:

1. To reduce fever, use:

tea with lemon, ginger, raspberries or viburnum,
tea or milk with honey, preferably linden. Add a tablespoon of honey to one glass of liquid,
cranberry or lingonberry juice.

2. To treat cough:

For one glass of milk put one teaspoon of honey and butter,
brew the breast mixture,
decoction of licorice or plantain root,
radish juice and honey. To do this, you need to cut off half the vegetable, make a hole in it and put a tablespoon of honey there. The next day, drink the resulting mixture.

3. To relieve the inflammatory process, drink herbal decoctions:

Brew one tablespoon of chamomile in boiling water for an hour. Drink throughout the day
black elderberry extract,
make a mixture of black elderberry, mint and linden flowers in equal proportions. Pour one tablespoon of the mixture into 500 ml of boiling water and boil for 10 minutes. The decoction should be strained and drunk 1-2 cups warm before bedtime.
mix linden flowers with raspberries and pour 500 ml of boiling water over two tablespoons of the mixture, cook for 7 minutes. Drink the strained decoction at night,
Brew 1 teaspoon of dry basil in a glass of hot water, drink throughout the day,
take 20 rosehips in a glass of water, bring to a boil and boil for 10 minutes under the lid, leave for a day. Drink the strained solution throughout the day.

You should not drink alcohol tinctures during a flu or cold. Although the herbs in their composition can be beneficial for the body, alcohol only weakens a person’s defenses.

It is best to prepare for cold season in advance by strengthening your body in natural ways. To do this, you need to eat right, rest, exercise and practice hardening. If it was not possible to protect yourself from the disease, treatment should be started as early as possible.

When should you use Ciproflaxacin?

Tsiprolet eye drops are used to treat infectious inflammation caused by strains sensitive to the drug. So, among the indications there will be:

infectious inflammation of the conjunctiva in acute and subacute forms (conjunctivitis);
inflammation caused by infection of the edges of the eyelids (blepharitis);
inflammatory processes of the cornea (keratitis) resulting from infection;
corneal ulcers of infectious origin;
infectious inflammation in the lacrimal sac (dacryocystitis);
inflammation in the cartilage of the eyelid as a result of coccal infection (meibomitis)

The drug and its analogues are also used to prevent infection of eye structures during surgery:

before ophthalmic surgery;
after surgery in case of infection of the eye structures;
in the treatment of infected eye injuries;
for prevention in the first hours after injury or foreign body entry.

Methods of instillation and doses

Instructions for use prescribe dropping drops 4-8 times a day, 1-2 drops into the conjunctival sac. The individual dose can only be determined by a doctor after an examination.

You should not self-prescribe these eye drops. Since their uncontrolled use can lead to negative consequences and increased side effects.

How does Ciprolex interact with other antibiotics and antimicrobials?

When Ciproflaxacin is used in combination with other antimicrobial drugs, synergism (mutual enhancement of the therapeutic effect) is most often observed.

Tsiprolet is effective in cases where treatment with aminoglycosides and tetracyclines, β-lactam antibiotics is ineffective.

But it does not affect some fungi, a number of anaerobic microorganisms and staphylococci that are resistant (insensitive) to methicillin.

Taking Tsiprolet correctly

Under no circumstances should you use such a strong antibiotic on your own. Tsiprolet should only be prescribed by a doctor for certain bacterial infections. The doctor also determines the required dose of medication and duration of treatment. In this case, it will not be amiss to adhere to the following recommendations:

Before starting antibiotic therapy, carefully read the instructions for the drug, and if you have any questions, contact your doctor or pharmacist for clarification.
Stick to the doses prescribed by your doctor and do not exceed them.
A 12-hour break should be maintained between doses of the drug, taking the antibiotic at the same time every day. This is necessary to achieve a constant concentration of the drug in the body.
The duration of treatment is usually 5-10 days, and for some diseases it may be necessary to take Tsiprolet for 2 weeks.
The tablets should be taken with plenty of water. In addition, you should increase the amount of water you drink during antibiotic therapy to prevent the development of crystalluria.
The drug is taken regardless of food intake.
It is necessary to avoid taking the medication and consuming dairy products at the same time, as they may reduce the effectiveness of the antibiotic.
During treatment, exposure to direct sunlight should be avoided due to the risk of photosensitivity.

Patient reviews

Marina, 35 years old, Moscow: “After the removal of a wisdom tooth, the soft tissues swelled.
This was accompanied by severe pain. The doctor prescribed Tsifran, which I took 2 times a day, 1 tablet. The swelling decreased on the third day, and completely disappeared on the seventh.” Yana, 19 years old, Vologda: “I recently got sick with a sore throat. I gargled with a soda-salt solution, which relieved swelling, but the effect was short-lived. After some time, the discomfort in the throat returned. The doctor recommended Tsiprolet. The swelling decreased the very next day, breathing became easier, and other symptoms also alleviated. After 2 days the swelling was completely gone.”

Description of the drug

Tsiprolet eye drops are produced in India. The drug is produced in plastic bottles with a 5 ml pipette. The cost of one package varies about 50 rubles.

benzalkonium chloride (solution) - 0.0002 ml;

It is important to take into account which group of antibiotics the main active component of Tsiprolet belongs to.

Substances in this group are similar to antibiotics in their action, but differ in chemical formula and have no analogues in nature.

Fluoroquinolone drugs should only be used as prescribed by a doctor.

Tsiprolet is effective against gram-negative bacteria (gonococci, Escherichia coli, Pseudomonas aeruginosa, chlamydia) and game-positive bacteria (staphylococci, pneumococci). The drug is also used in the treatment of tuberculosis infection, due to its activity against mycobacteria. It is not recommended to use Tsiprolet against anaerobic infections.

It is quite difficult to unequivocally answer the question of whether it is an antibiotic. Disputes about classifying it as one or another group of drugs are still ongoing. “Tsiprolet” is a fluoroquinolone, the effect of which is to destroy the DNA of a harmful microorganism and its further death. Fluoroquinolones are active both against those bacteria that begin to actively reproduce and those that are dormant.

According to the instructions for use for Tsiprolet tablets, the spectrum of action of the active substances of the drug covers both gram-positive and gram-negative bacteria, which allows the drug to be used for various infectious diseases. This is the main similarity between fluoroquinolones and antibiotics.

These groups of substances differ in origin and chemical structure. Antibiotics are naturally occurring substances or synthesized analogues, while fluoroquinolones do not have similar natural substances.

Thus, it is a man-made antibacterial drug.

Which is better – Ciprofloxacin or Ciprolet

By comparing the drugs, you can decide which one is more preferable in terms of therapeutic effect and is safe for the body.

Compound

Both medicines are based on the same active ingredient with a broad-spectrum antibacterial effect. Therefore, in treatment, one of these medications can be replaced by another.

Therapeutic effect

Both antibacterial agents are effective in combating infectious processes, including chronic ones. Tsiprolet is considered more preferable in therapy, since it is purified from impurities and has fewer side effects.

Release form

Medicines are produced in identical dosage forms. Dosages, concentrations and volumes are also similar.

Contraindications

The range of contraindications are indicated in the accompanying instructions and are almost identical to each other.

Pricing policy and manufacturers

Ciprofloxacin is produced primarily in Russia, although there are tablets produced in the Netherlands on the market. Tsiprolet is manufactured in India. Prices for imported medicines are slightly higher than for domestic ones.

Tsiprolet tablets instructions

The drug Tsiprolet is used in medicine to treat infectious diseases of varying degrees of complexity and is prescribed to the patient only with a prescription from the attending physician. Information on its use is contained in the instructions below.

The drug is available in the form of round tablets with a snow-white and smooth surface. At the fracture site you can see a mass of yellowish tint.

The main substance in the tablet is ciprofloxacin hydrochloride, and additional components include:

corn starch;
croscarmellose sodium;
special talc.

The outer shell consists of hypromellose, dimethicone, macrogol, polysorbate, sorbic acid, purified talc, titanium dioxide.

A good cardboard box contains 10 tablets, each containing 250 mg of ciprofloxacin.

You can also find on sale the same tablets with an identical composition, only they contain a larger amount of ciprofloxacin, namely 500 mg.

Tsiprolet is valid for three years, starting from the date of issue. Store it in a place protected from children, where there is no excess light and humidity. The optimal temperature for preserving all medicinal properties is 25 degrees.

Pharmacology

Tsiprolet is prescribed when it is necessary to treat bacteria in the body. It is based on an active substance called ciprofloxacin, an antimicrobial substance of the fluoroquinolone group. It significantly affects the state of bacterial DNA gyrase, which helps get rid of negative reproduction of microbial DNA.

Ciprofloxacin does not affect the general condition of the natural intestinal microflora. It is active against resistant bacteria, such as antibiotics or tetracyclines.

After taking the medicine, ciprofloxacin is absorbed quite quickly and well. The ability of the drug to be absorbed in the body reaches a maximum of eighty-five percent, and its volume of distribution is two to three liters per kilogram of weight. It penetrates tissues and organs quite well, and a certain amount remains in the bones. Up to twenty to forty percent binds to blood plasma proteins.

The required concentration of this substance to fight bacteria remains in the human body for no more than twelve hours.

Ciprofloxacin leaves the body mostly unchanged through the work of the kidneys - more than fifty percent. After internal use of the drug, it should take three to five hours for partial release, and after injection - four hours. A significant dose of ciprofloxacin leaves the body through the intestines in the form of bile and feces.

Ciprolet can be used for quite a long time as prescribed by a doctor, since insensitivity to ciprofloxacin develops over a long period of time and resistance of plasmid origin is not observed.

Pharmacokinetics

After swallowing the tablet, its main component is absorbed from the gastrointestinal tract very quickly. In this case, bioavailability ranges from 50 to 85 percent.

The drug taken orally is distributed throughout the tissues and fluids in the body. But most of the substances are found in bile, kidneys, tonsils, and endometrium. In girls, it also settles in the uterus, fallopian tubes and ovaries, and in boys - in the seminal fluid and prostate.

Ciprofloxacin also penetrates to the same extent into the ocular fluid, saliva, epidermis, muscles, lymph, bones, peritoneum and bronchial secretions.

In patients with well-coordinated renal function, the drug leaves the body in no more than 5 hours. Although most of it falls on the kidneys, excretion also occurs to a certain extent through feces and urine.

Effect of the drug

The composition of Tsiprolet eye drops is unique, and the drug has a low level of toxicity.
This allows you to use the product for a long time without the risk of becoming addicted to antibiotics. Eye drops act locally. The active substance quickly penetrates the affected tissue. After three hours, the activity of the drug decreases. The drug does not enter the general and systemic circulation. Tsiprolet is excreted from the body by the kidneys, a small part - by the intestines.

As a result of the action of ciprofloxacin, the formation of protein molecules and the growth of cell walls of pathogenic microorganisms is disrupted, which causes their death.

Ciprofloxacin is active against gram-positive and gram-negative bacteria. It inhibits the reproduction and growth of staphylococci, enterobacteria, salmonella, mycobacteria, and pneumococci.

The active substance not only destroys pathogenic microflora, but also inhibits the development of antibiotic resistance. Resistance in bacteria develops extremely slowly, so the drug effectively copes with the infection.

Ciprofloxacin also destroys pathogenic microbes that are resistant to antibiotics of the tetracycline, penicillin, and cephalosporin groups.

What do Tsiprolet drops help with?

Drops are used to overcome eye infections and various inflammations of the tear ducts. Main indications:

conjunctivitis, both acute and chronic;
blepharitis;
blepharoconjunctivitis;
corneal lesions, which are in the nature of ulcers, which may be accompanied by a secondary infection;
keratitis - bacterial infection of the cornea;
also used for barley;
dacryocystitis and meibomitis - inflammatory processes of the tear ducts and eyelids;
injuries to the eyeballs and foreign bodies that provoke the appearance of an infectious process.

In order to prevent certain complications, it is advisable to use such drops in preparation for surgical interventions on the eyes.

Indications

The antibacterial drug Tsiprolet is recommended for use in various pathological processes that are infectious and inflammatory in nature. Typically, many doctors recommend taking this remedy for complications that develop after acute respiratory infectious processes of a viral nature.

Viruses cause an inflammatory process in the mucous membrane of the respiratory system, which leads to easy penetration of harmful microflora. It is the use of Tsiprolet that helps eliminate bronchitis and focal pneumonia.

Tsiprolet is prescribed not only for the flu; there are other indications that are indicated in the instructions:

Inflammation in the kidneys and bladder;
Pathologies of urological and gynecological nature;
The drug is highly effective in surgery. It is actively used to eliminate abscesses, boils, phlegmons, carbuncles, mastitis, and other pathologies in which suppuration is observed in different areas of the body;
For infections in the nasal cavity, throat, ear;
Helps with infections in joints and bones;
The product in the form of drops helps eliminate infectious processes in the organs of vision.