Omez clarithromycin amoxicillin how to take

We continue the series of articles about such a dangerous microorganism as the bacterium Helicobacter pylori. The article is devoted to the topic: Helicobacter pylori symptoms and treatment. It shows the eradication of Helicobacter according to Maastricht V, presents modern methods of anti-Helicobacter therapy - first, second and third lines, describes which drugs are best used in regimens and why, how to avoid unpleasant side effects. Also, what tests to take to determine the success of therapy.

Symptoms of infection are described in detail in the previous article (link just above). Here we will pay full attention to treatment standards, especially drug regimens with antibiotics for Helicobacter.

Therapy with traditional methods has always been questioned and is only possible as an additional remedy - in parallel with Helicobacter therapy during remission of gastritis or ulcers. Acute conditions are treated only with antibiotics. Which antibiotics are effective are described in generally accepted regimens.

There will be a separate article on nutrition (diet) and traditional methods of therapy. I plan to provide a video of a doctor who uses dietary supplements to eradicate Helicobacter and some folk recipes - when it is not possible to prescribe antibiotics for a number of reasons.

What antibiotics should you take for gastritis?

Nonsteroidal anti-inflammatory drugs NSAIDs are one of the most popular groups of drugs. With regular use of these drugs, damage to the upper gastrointestinal tract often develops - erosive and ulcerative lesions, perforation of the stomach and duodenum, gastric bleeding.

Omez, when taking NSAIDs, prevents the development of gastropathy. In the presence of two or more risk factors, the frequency of complications of NSAID therapy increases. In this case, doctors at the Yusupov Hospital simultaneously use two preventive tactics: selective COX-2 inhibitors and proton pump inhibitors.

A serious problem is the use of non-steroidal anti-inflammatory drugs in patients with risk factors for damage to the upper gastrointestinal tract. Reflux esophagitis, exacerbation of peptic ulcer disease, erosive gastroduodenitis are contraindications to the use of NSAIDs. However, the severity of the pain syndrome often forces anti-inflammatory therapy to be carried out in such patients.

If there are risk factors, professors and doctors of the highest category at the Yusupov Hospital discuss patient management tactics at a meeting of the expert council. NSAIDs are prescribed only after a comprehensive examination of the patient using modern diagnostic equipment from leading European, Japanese and American companies. Non-steroidal anti-inflammatory drugs are changed for patients. In the presence of risk factors for the development of gastropathy, selective inhibitors of COX cyclooxygenase are used. This isoenzyme accumulates only in the site of inflammation, while the COX-1 isoenzyme is present in many tissues and provides protection to the cells of the mucous membrane of the digestive tract.

Treatment with COX-2 inhibitors does not completely eliminate the possibility of side effects from the stomach and duodenum. Misoprostol has protective properties against the gastrointestinal tract. When prescribing the drug in combination with a non-selective NSAID, the risk of ulcerative complications is reduced by 2 times.

Doctors carry out preventive treatment of gastropathy with proton pump inhibitors, which include Omez. The main active ingredient reduces the secretion of gastric juice. Omez is a specific proton pump inhibitor. Omeprazole is a weak base that is concentrated and converted to its active form in the acidic environment of the intracellular tubules of the stomach cells that produce hydrochloric acid. It inhibits the acid pump, thereby inhibiting the secretion of hydrochloric acid.

When taking 20 mg of omeprazole, there is a rapid and effective suppression of daytime and nighttime gastric juice production. Omez is taken orally once a day with a small amount of water. Taking the drug simultaneously with food does not affect its effectiveness. In patients with severe liver failure, Omez is prescribed in a daily dose not exceeding 20 mg. The duration of taking the course dose should be at least four weeks, and for large sizes and localization of ulcers in the stomach - from 8 to 12 weeks.

Patients taking the drug Omez may experience headache, dizziness, agitation, drowsiness or insomnia, paresthesia, tingling in the limbs, depression or hallucinations. From the musculoskeletal system, muscle weakness, myalgia, and joint pain are observed. Omez affects the hematopoietic system.

Skin reactions may occur: itching, photosensitivity, erythema multiforme, baldness and allergic manifestations of urticaria, bronchospasm, angioedema, interstitial nephritis and anaphylactic shock. Adverse reactions occur rarely and are reversible. Contraindications to the use of Omez include pregnancy and lactation, childhood, and hypersensitivity to the drug.

A side effect of NSAIDs is the damaging effect of the drugs on the digestive organs, which can lead to serious complications. NSAID gastropathy is an erosive and ulcerative lesion of the gastroduodenal region that occurs when using non-steroidal anti-inflammatory drugs and has a characteristic clinical and endoscopic picture. They have the following features:. Changes in the mucous membrane of the stomach and duodenum are often recurrent.

They are accompanied by minimal subjective sensations or occur with a complete absence of clinical manifestations. In this case, doctors at the Yusupov Hospital find endoscopic signs of damage to the digestive organs during preventive esophagogastroduodenoscopy.

In the formation of NSAID gastropathy, an imbalance between the factors of aggression and protection of the gastric mucosa is essential. At the same time, NSAIDs affect all levels of the protective intestinal barrier - preepithelial, epithelial and postepithelial. The reason for the development of NSAID gastropathy is:.

In the mechanism of ulcer-forming action of NSAIDs, an important role is played by damage to the hydrophobic layer on the surface of the gastric mucosa, depletion of the composition of phospholipids and a decrease in the secretion of gastric mucus components. When taking NSAIDs, blood circulation in the submucosal layer of the gastrointestinal tract is disrupted and an additional risk of damage to the mucous membrane of the stomach and duodenum is created. Changing the balance of protective and aggressive gastric environments leads to the formation of ulcers and the development of complications.

The likelihood of developing ulcers and erosions of the digestive organs increases in patients infected with Helicobacter pylori. For this reason, doctors at the Yusupov Hospital, before starting to take NSAIDs, prescribe drugs that destroy this microorganism to patients who have been diagnosed with this microorganism, and during treatment, proton pump inhibitors Omez. To prevent damage to the digestive tract caused by NSAIDs, doctors at the Yusupov Hospital prescribe prophylactic treatment to all patients with previously confirmed peptic ulcers while taking NSAIDs.

In the presence of two risk factors other than a history of peptic ulcer, prophylactic therapy is given to all patients. If patients take non-selective NSAIDs, prophylactic treatment is carried out in the presence of one risk factor. In patients with low relative risk indicators, before starting NSAID therapy, preference is given to selective COX-2 inhibitors, and testing for the presence of Helicobacter Pylori infection is performed using a rapid urease test, a breath test, a morphological method, or determination of Helicobacter Pylori antibodies in the blood.

If the test results are positive, a proton pump blocker, clarithromycin, amoxicillin is prescribed, or quadruple therapy regimens with a proton pump blocker, bismuth preparations, tetracycline, and metronidazole are used. If the presence of infection is confirmed, therapy is carried out aimed at destroying Helicobacter pylori, followed by taking a proton pump blocker - Omez for the entire duration of NSAID use. If this is possible, then after transferring the patient to selective COX-2 inhibitors, Omez proton pump blockers are prescribed in standard doses for a course of 4 to 8 weeks.

If it is not possible to discontinue aspirin and non-selective NSAIDs, treatment of erosive and ulcerative lesions is carried out against the background of their continued use. In this case, continuous maintenance therapy is prescribed with standard or double doses of proton pump blockers; if an infection is detected, therapy is carried out aimed at destroying Helicobacter pylori.

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Home Articles Neurology. Omez when taking NSAIDs. Alexey Vladimirovich Vasiliev. Nazarenko, A. Moscow, Clinical laboratory analytics. Fundamentals of clinical laboratory analysis V. V. Menshikov, Our specialists. Vladimir Vladimirovich Kvasovka. Deputy General Director for Medical Affairs, general practitioner, gastroenterologist, candidate of medical sciences.

Make an appointment. Alexey Sergeevich Smychkov. Doctor of functional diagnostics, candidate of medical sciences.

Ilya Andreevich Gudkov. Anesthesiologist-resuscitator, cardiologist, functional diagnostics doctor. Valeria Vladimirovna Borzetsovskaya.

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Features of taking medications

In order for the treatment of gastritis, ulcers, and other gastrointestinal pathologies to be effective, you must comply with the conditions for using medications. This way, substances from different medications will not negatively affect the action of the combined medications.

Features of bismuth treatment

De-nol is consumed half an hour before meals. 120 mg tablets are taken twice or 4 times a day with the same time interval. Take 75 ml of water.

At the same time as De-Nol, as well as within half an hour before/after taking it, you should not consume:

Phosphalugel and other anacids;
fruit juices;
milk;
alkaline waters;
some antibiotics.

Adults and adolescents over 12 years of age are allowed to consume 480 mg of bismuth per day (4 De-Nol tablets). For younger children, a gastroenterologist selects an individual norm. The drug is used continuously for 28–56 days. The course can be repeated after 2 months.

Taking penicillins

Penicillins include Amoxicillin, Amosin, Ospamox, Flemoxin, Hiconcil and other single-component antibiotics with the active ingredient amoxicillin. This drug enhances the effect of metronidazole, rifampicin and other bactericidal drugs.

Antibiotic dosage regimen for adults or children heavier than 40 kg:

the maximum dosage of amoxicillin is 3 g/day;
Amoxicillin is taken 3 times a day, 0.25-1 g, with equal 8-hour intervals between doses for 7-10 days.

Amoxillin is well absorbed from the gastrointestinal tract, regardless of the presence or absence of food in the stomach, but it is not recommended to take De-Nol together with an antibiotic. The bismuth preparation is drunk according to the instructions before meals, and amoxicillin products are taken a couple of hours after meals.

Taking macrolides

Macrolides include single-component antibiotics containing clarithromycin or azithromycin. The list of drugs containing clarithromycin includes Bacticap, Kispar, Klabax, Klacid and other drugs. Products containing azithromycin include Azithromycin, Azibiot, Azitrox, Zi-factor, Sumamed, Hemomycin, and other single-component antibiotics.

De-Nol is consumed according to the instructions, and macrolides are drunk on an empty stomach 1-2 times a day: 60 minutes before or 2 hours after consuming food and anacids. The daily dosage of azithromycin for patients heavier than 45 kg and over 12 years of age is 500 mg. For clarithromycin, the daily dose is 1-2 g.

Approximate drug combination scheme for adults:

De-Nol - half an hour before breakfast and dinner, 240 mg of bismuth (480 mg/day);
Azithromycin - after lunch 2 hours later (1 r./day) or Clarithromycin 120 minutes after breakfast, dinner (2 r./day).

Macrolide therapy lasts 3–14 days. The patient’s attending physician must clarify the sequence of medication consumption and course duration.

Taking tetracyclines

Tetracyclines include single-component antibiotics with the active ingredient tetracycline. The absorption of drugs is affected by food and anacid medications. De-Nol should not be taken with antibiotics of this group, since the gastroprotector reduces their absorption. For 1-2 weeks, tetracycline should be taken a couple of hours after consuming food and antacids. The break with the bismuth preparation should be at least 150 minutes.

Taking metronidazole

Preparations containing the substance metronidazole are not antibiotics, but they are active against Helicobacter bacteria and have antiulcer and antiprotozoal properties. The De-Nol substance enhances their antimicrobial effect.

Metronidazole is taken for 1-1.5 weeks with or after food. Adults take 500 mg three times a day. De-Nol is drunk according to the instructions in the instructions.

Is it possible to take Clarithromycin and Amoxicillin at the same time? It's worth finding out!

Currently, the pharmaceutical market provides a wide range of drugs designed to treat various forms of gastritis. However, not all such drugs are highly effective and safe means for the treatment of diseases of the gastrointestinal tract. Today, many patients, having tried a lot of different medications, choose Omez. This is due, first of all, to the fact that Omez for gastritis allows you to quickly relieve all the main symptoms of this disease.

I started taking clarithromycin + amoxosocialin + omez + linex for Helicobacter therapy. On the first day of admission, diarrhea began, I think from barium (I did an x-ray of the stomach). Possibly. But on the second day there was a slight bitterness in the mouth, chapped lips, dry mucous membranes.

Clarithromycin against microbe

Clarithromycin is one of the most common medications used to treat gastritis and other diseases with Helicobacter pylori. It is usually prescribed as part of three-component eradication therapy. The advantage of the bactericidal agent is its low toxicity. Only 2% of patients experienced adverse reactions, such as:

nausea;
indigestion;
vomit;
stomatitis (very rare).

Clarithromycin is combined with antisecretory drugs from the PPI group. They are included together in eradication therapy to enhance the effect. It is not recommended to use clarithromycin if the body is intolerant of its components, under the age of 6 months, in the first trimester of pregnancy, with liver and kidney failure.

Amoxicillin and clarithromycin how to take together

Diseases of the digestive system are widespread everywhere. They require a long period of treatment and lifestyle adjustments. Omez and De-Nol occupy a key place in basic therapy. They belong to different pharmacological groups and influence individual parts of the pathogenesis of gastrointestinal diseases. To understand the effect of taking these drugs together, it is necessary to understand what each drug is individually. Omez is a well-known representative of the group of proton pump inhibitors. Its main effect - reducing the acidity of gastric juice - is due to its ability to reduce the production of hydrochloric acid. Note! According to modern data, Omez can be prescribed in childhood.

How to reduce adverse reactions during treatment

With any treatment regimen, deterioration of health, weakness, tachycardia, nausea, vomiting, and diarrhea are possible. In case of diarrhea, we add Loperamide or Enterol; in case of severe headaches, we add analgesics.

What can be done to make the treatment process less difficult? There is only one answer: do not save on the price of drugs. There are expensive and cheaper antibiotics. It all depends on the manufacturer. When purchasing more expensive brand name tablets, there are far fewer adverse reactions. Sometimes they may be completely absent.

Thus, it is better to buy Josamycin as Vilprafen® Solutab produced by ASTELLAS PHARMA EUROPE BV (Netherlands).

It is better to buy amoxicillin as Flemoxin Solutab® produced by ASTELLAS PHARMA EUROPE BV (Netherlands). It is better to dissolve Flemoxin in a small volume of water, the form allows it. More is said about it above.

De-Nol - buy DE-NOL® produced by ASTELLAS PHARMA EUROPE. If tolerance is poor, De-Nol can be divided into 4 doses of 1 tablet each. Take 20 minutes before meals - this is how long the drug needs to contact the gastric mucosa and form a protective film.

High-quality clarithromycin is CLACID® tablets, manufacturer: ABBOTT LABORATORIES GmbH (Germany). Pay attention that there is no CP - this is a prolonged form, you need the regular one.

High-quality nifuratel - Macmiror® Manufacturer: POLICHEM SrL (Italy).

Tablets from the listed manufacturers have better tolerability and bioavailability, cause fewer side effects, which will make it possible to withstand 14-day therapy.

Tolerability of medications also depends on the distribution of their intake throughout the day . The optimal distribution is as follows: PPI and solutabs (Vilprafen and Flemoxin) both in the morning before meals half an hour and before dinner half an hour, and De-Nol - at lunch before meals and before bed.

How to take Amoxicillin for stomach ulcers?

Excipients: mannitol - mg, crospovidone - 18 mg, poloxamer - 5 mg, hypromellose - 8 mg, meglumine - 3 mg. Coating composition: povidone K - Enteric coating composition: methacrylic acid-ethyl acrylate copolymer methacrylic acid copolymer [type C] - 72 mg, triethyl acetate - 7. Capsule cap composition: iron dye yellow oxide E, titanium dioxide E, sodium lauryl sulfate, water, gelatin . Omeprazole is a racemic mixture of two enantiomers that reduces the secretion of hydrochloric acid due to specific inhibition of the proton pump of gastric parietal cells.

Description of Flemoxin Solutab

The drug Flemoxin Solutab is available only in tablet form. The active ingredient is amoxicillin. Produced by Astellas Pharma Europe, the Netherlands and ORTAT, Russia.

This is an antibacterial drug with bactericidal action. It is active against many pathogenic microorganisms, including Helicobacter pylori, streptococci, staphylococci, shigella, clostridia.

Research and effectiveness

Flemoxin Solutab is especially valued in pediatric practice. Its effectiveness and bioavailability do not differ depending on the route of administration. It has minimal irritating effect on the gastrointestinal tract. Flemoxin is preferred in the treatment of bronchitis and other recurrent bronchopulmonary diseases.

The effectiveness and safety of the drug was studied in the Department of Pulmonology and Microbiology of the Scientific Center for Diagnostics of the Russian Academy of Medical Sciences. 95 children were under observation. As a result, the drug was well tolerated without significant side effects. Flemoxin shows high clinical and bacterial effectiveness in acute and chronic diseases of the lungs and bronchi in children.

Source: Clinical and bacteriological effectiveness of the innovative form Flemoxin Solutab for respiratory diseases in children. Sereda E.V. Difficult patient. 2010.

Contraindications

Flemoxin is contraindicated in case of intolerance to amoxicillin and other beta-lactam antibiotics. Use with caution for mononucleosis, ulcerative lesions of the gastrointestinal tract, and renal failure.

During pregnancy, the medicine is prescribed because the benefits significantly outweigh the possible risks. This also applies to the period of breastfeeding.

How to take amoxicillin and clarithromycin at the same time

Given the infectious nature of the pathology, doctors use antibiotic drugs to combat the disease. The need to take Amoxicillin and Clarithromycin together is usually caused by an exacerbation of ulcerative lesions. Clarithromycin is also an antibiotic drug, but from the Macrolide group. Antibiotics of the Macrolide group have antimicrobial, anti-inflammatory and bacteriostatic properties. Moreover, Clarithromycin is able to suppress the synthesis of proteins necessary for the life of pathogenic microorganisms, and thereby prevent their development and reproduction. Thus, both drugs are capable of affecting only microorganisms related to bacteria.

Amoxicillin against bacteria

Treatment of bacteria with amoxicillin is quite common. This medication is included in various eradication therapy regimens, not only in the first line, but also in the second line. This is a semi-synthetic penicillin with a bactericidal effect. Its activity manifests itself only on microorganisms that are at the reproduction stage. Thus, the drug is not used simultaneously with drugs that inhibit the division of microbes.

Amoxicillin contraindications:

increased sensitivity of the body to penicillins;
mononucleosis of infectious nature;
predisposition to leukemoid reactions.

During pregnancy and kidney disease, the antibacterial agent is used with caution.

OMEZ for heartburn and other troubles

VIDEO ON THE TOPIC: Clarithromycin tablets - indications (video instructions) description, reviews
A common medicine for the treatment of peptic ulcers and other gastric pathologies is Omez in various forms of release. The prescription of the drug must be carried out in compliance with a number of important recommendations contained in the instructions for use. The prices given in this article, as well as reviews from patients and doctors, registered analogues of Omez in Russia will help each patient make a rational choice. The active ingredient in the medical drug Omez, international name in Latin - Omez, is Omeprazole. The amount of active ingredient differs in different release forms. Manufacturer Dr.

Amoxicillin, Clarithromycin and Omeprazole are the active components of a combination drug that is used in the treatment of gastric and duodenal ulcers. Its effectiveness has also been proven in the fight against Helicobacter pylori infection.

Indications and contraindications

Therapy including Omeprazole, Clarithromycin and Amoxicillin is used to treat:

Helicobacter pylori infections;
peptic ulcers of the duodenum and stomach;
reflux esophagitis.

For these indications, the drug is prescribed by a doctor, who also discusses the dose and time of administration. The treatment takes a long time, one tablet will not help. For example, for peptic ulcers, the drug is taken for up to 8 weeks, and the dose of the drug is up to 40 mg/day.

It is not recommended to take the drugs together:

people with drug intolerance;
pregnant and lactating women;
simultaneously with other drugs from this group of drugs;
patients with impaired liver function.

As side effects with long-term use of the drug, people may experience headache, constipation, flatulence, diarrhea, abdominal pain and colic, vomiting and nausea. Adverse reactions occur infrequently, mainly in people who take three drugs at the same time (not counting the complex).

Omez when taking NSAIDs

When your stomach hurts and there is heartburn, you want to quickly take an effective medicine. But how to take Omeprazole to restore gastrointestinal and intestinal function, who is indicated and contraindicated, what side effects does it have and can it be replaced with other analogues? It's worth looking at in more detail. The medicine affects the enzyme in the stomach as part of hydrochloric acid, suppresses secretion, accelerates the exchange of hydrogen ions in the mucus of the epithelium, thereby blocking the production of hydrochloric acid products. The release form of the medicine is hard capsules 10, 20, 40 mg. Packaging - cellular, contour. Pack - cardboard or polymer cans 10, 20 mg.

Omez is an antiulcer drug that has an inhibitory effect on stimulating gastric acid secretion. The effect of the drug appears an hour after administration, reaches its maximum after about two hours and persists throughout the day. A single dose turns out to be quite effective, as it completely suppresses the increased secretion of hydrochloric acid.

About the drug Omeprazole

One of the modern antisecretory drugs, Omeprazole, is widely used to treat gastric ulcers and other erosive and inflammatory disorders of the upper digestive tract. Its mechanism of action is based on the inhibitory properties of the biologically active substance omeprazole. It can suppress the formation of HCl in the stomach and reduce its activity.

Omeprazole exhibits its properties only in the acidic environment of the stomach. Here it penetrates the parietal cells, which are responsible for the production of hydrochloric acid. Accumulating in cellular structures, omeprazole controls the formation of gastric juice and the enzyme pepsin.

In addition, Omeprazole kills Helicobacter pylori. This bacterium is the main cause of gastritis.

Omeprazole helps normalize the acidity of gastric juice and significantly reduces the risk of developing reflux disease of the esophagus and erosive esophagitis. It significantly improves the condition of patients, but also leads to a reduction in the development of various complications.

It should be noted that the effect begins within one hour after administration and lasts about 24 hours. Just one dose per day can provide rapid and effective extinction of gastric secretion, and reaches a maximum 4 days after the start of treatment. After stopping the medication, the secretory activity of the stomach is completely restored in less than a week.

Indications for simultaneous use

Both antibiotics act only on bacterial microorganisms and, when combined in pairs, enhance each other’s effect. In combination they are prescribed for the following pathologies:

Gastrointestinal diseases of a bacteriological nature: stomach ulcers, chronic gastritis, stomach cancer;
infections of the upper and lower respiratory organs;
tuberculosis;
skin bacterial lesions.

Such complex therapy is also indicated for chronic diseases that cannot be treated with a single antibiotic.

What determines the ineffectiveness of eradication?

Sometimes, during deep therapy of helibacteriosis, it is not possible to destroy pathogenic microorganisms. This is a consequence of the following errors:

the use of medications that are not included in the developed treatment regimens or the prescription of incorrect doses;
short therapeutic course;
lack of laboratory control.

If you do not follow the prescribed dosages and do not adhere to bacteria eradication regimens, the risk of side effects increases. If you refuse to take medications, severe complications cannot be ruled out. Therefore, it is necessary to strictly follow all the instructions of the attending physician in order to get rid of unpleasant symptoms and avoid serious consequences.

Brief description of Clarithromycin

Clarithromycin belongs to the group of semisynthetic macrolides. Blocks the work of ribosomes in bacteria, which leads to their death. The characteristics of the chemical formula of the antibiotic provide resistance to the action of gastric juice.

Used as a first-line antibacterial drug in the treatment of peptic ulcers.

It is also destructive for staphylococci, streptococci, various types of Neisseria, chlamydia, ureaplasma, etc. It is widely used in therapeutic, urological and gynecological practices.