Ibuprofen instructions and cheaper analogues for adults and children

Indications for use

Indications for prescribing the drug are:

• Moderate or mild pain syndrome of various origins (including migraine, headache, myalgia of non-rheumatic and rheumatic origin, toothache, post-operative pain, neuralgia, primary algodismenorrhea, sore throat and ear pain, post-traumatic pain).
• Inflammatory diseases of the spine and joints (including rheumatoid and rheumatoid arthritis, deforming osteoarthritis, ankylosing spondylitis, gouty arthritis).
• Feverish syndrome in infectious and “cold” diseases.

Additionally for suppositories: pain syndrome of moderate or mild intensity (including pain in the throat and ears, pain due to ligament damage, etc.), acute respiratory diseases, post-vaccination reactions, childhood infections, influenza and other infectious and inflammatory pathologies accompanied by increased body temperature.

Additionally for the suspension: articular syndrome with exacerbation of gout, bursitis, tendonitis, radiculitis, psoriatic arthritis, traumatic inflammation of the musculoskeletal system and soft tissues, pain syndrome with adnexitis.

Additionally for the gel: humeroscapular periarthritis, sciatica, osteochondrosis with radicular syndrome, lumbago, tendovaginitis, injuries without compromising the integrity of soft tissues (including post-traumatic swelling, bruises).

Ibuprofen for children

Children under 6 years of age cannot be treated with ibuprofen tablets. There are also certain weight restrictions. It is allowed to treat with the drug if the child’s weight after 6 years is more than 20 kg. Otherwise, contraindications to taking ibuprofen, which are confirmed by the instructions, are extended until the child reaches 12 years of age.

It is very important not to exceed the maximum permissible daily dosage. Children under 12 years of age should take no more than 4 tablets per day in four divided doses. The break between doses should be at least 4 hours.

In any case, even if you follow doctor’s recommendations, it is necessary to monitor the child’s condition while using ibuprofen. As confirmed in practice, side effects occur very often. Sometimes headaches and insomnia occur, which worsens the baby’s general condition. The digestive system often reacts negatively to taking medication. This is expressed by abdominal pain and various dyspeptic disorders. If you are predisposed to allergic reactions, skin rash, irritation and itching may appear during treatment. If any unpleasant symptoms are detected, you should stop using the drug and consult a doctor.

pharmachologic effect

The clinical and pharmacological effect of Ibuprofen tablets is due to a decrease in the synthesis of the main mediator of the inflammatory reaction, prostaglandin, which is responsible for the development of pain, tissue swelling and increased body temperature. A decrease in the concentration of prostaglandins occurs due to ibuprofen blocking the enzyme cycloxygenase (COX 1 and 2), which catalyzes the reaction of converting arachidonic acid into prostaglandins during the development of the inflammatory reaction.

After taking Ibuprofen tablets orally, the active substance is quickly and almost completely absorbed into the systemic circulation from the lumen of the small intestine. Ibuprofen reaches its maximum concentration in the blood after 2 hours. It is almost evenly distributed in all tissues of the body. Penetrates through the blood-brain barrier into the structures of the central nervous system, and can also enter the body of the developing fetus during pregnancy and breast milk during lactation. Ibuprofen is metabolized in the liver to form inactive breakdown products, which are excreted from the body in the urine.

Operating principle

Once in the child’s body, ibuprofen affects the process of prostaglandin synthesis, the inhibition of which is responsible for the analgesic and anti-inflammatory effect of the suspension.
The drug also has an antipyretic effect and the ability to suppress platelet aggregation. After oral administration, the active compound is absorbed from the stomach quite well. The drug begins to act 20-30 minutes after swallowing, and its therapeutic effect lasts up to 3-4 hours. The medicine is excreted mainly by the kidneys, completely leaving the body after a single dose within 24 hours.

Once in the child’s body, ibuprofen affects the formation of substances called prostaglandins. They are responsible for the development of the inflammatory process and the conduction of pain impulses, therefore the main effects of the drug are reducing the activity of inflammation and pain relief.

The effect of the medicine develops 20-40 minutes after its use, and the duration of the therapeutic effect depends on the form used, dosage and age of the patient. For example, rectal suppositories have a very long-lasting effect (up to 8 hours), and the antipyretic effect of tablets or capsules lasts up to 3-4 hours.

Indications for use

Ibuprofen - syrup and other forms of the drug - is often used in complex therapy. However, the medicine can also be used as an independent remedy. Indications for use, which are prescribed in the instructions, are the following situations:

• various diseases of the joints and bones (arthritis, arthrosis, articular gout, etc.);
• neurological problems (as symptomatic therapy);
• fever of various origins, also after vaccination;
• colds, flu, viral diseases and bacterial ailments (to relieve symptoms).

The drug copes excellently with pain. This is exactly what reviews say about the drug Ibuprofen. Therefore, it is often prescribed by doctors for the treatment of ENT organs (tonsillitis, otitis, eustachitis, etc.) simultaneously with other medications. The medication can also be used for gynecological problems and abdominal pain. However, this use is permitted only after consultation with a doctor, since independent use can give a blurred clinical picture and lead to the inability to make a correct diagnosis. This picture is fraught with complications.

Reviews

Reviews of the medicine are mostly positive. According to mothers, in most cases the suspension helps reduce fever or relieve pain, and children rarely protest against its sweet taste. One of the advantages of the medicine is its affordable price (compared to analogues).

Side effects after taking syrup are rare, but sometimes babies do not like the smell or taste of such a medicine. The disadvantages include the fact that the bottle is glass, and the lid opens very easily (there is no child protection).

What effect can Ibuprofen suspension achieve? Instructions for use for children of this drug contain a description of its pharmacological effects. The syrup helps to reduce body temperature and reduce pain. Many parents confirm that in the acute stage of colds and infectious diseases, Ibuprofen helps alleviate the condition of young patients.

However, there are a number of cases when the use of the drug is not recommended. So, for example, in case of acute abdominal pain, Ibuprofen can blur the picture of the disease, and then diagnosis will take much longer. In any case, the drug should be given to the child only as directed by the attending physician.

Reviews of the use of Ibuprofen are mostly positive. Mothers confirm that this medicine effectively relieves pain and lowers temperature. Side effects of Ibuprofen, according to parents, are quite rare and are often represented by negative gastrointestinal symptoms, headaches or allergies.

Doctors also note that the medication is effective and approved for children. Dr. Komarovsky calls it one of the drugs of choice for fever in a small child, along with paracetamol.

Suppositories are often chosen for infants and this form is praised for the absence of additional harmful chemical components. In addition, suppositories last longer than the suspension, the bitter-sweet aftertaste of which is sometimes not liked by the small patient.

However, the suspension is also very popular, since this form of Ibuprofen is easy to give even to an infant. Its only disadvantage is the packaging, since the glass bottle can be broken, and such a drug often does not have child protection on the lid.

Useful video about Ibuprofen

https://youtube.com/watch?v=QwhRIjCzIw4

List of sources:

• Simmons DL Variants of cyclooxygenase-1 and their roles in medicine. Thromb Res 2003; 110 (5-6): 265-268.
• Rao P., Knaus EE Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): Cyclooxygenase (COX) inhibition and beyond. J Pharm & Pharm Sci 2008; 11: 81s—110s.
• Herndon CM, Hutchison RW, Berdine HJ et al. Management of Chronic Nonmalignant Pain with Nonsteroidal Antiinflammatory Drugs Joint Opinion Statement of the Ambulatory Care, Cardiology, and Pain and Palliative Care Practice and Research Networks of the American College of Clinical Pharmacy. Pharmacotherapy 2008; 28 (6): 788–805.
• Henry D., Lim LL-Y., Rodriguez LG et al. Variability in risk of gastrointestinal complications with individual NSAIDs: results of a collaborative meta-analysis. Br Med J 1996; 312: 1563–1566.

Analogs

If necessary, Ibuprofen ointment can be replaced with other agents that have a similar effect. But you cannot make such a decision on your own: before changing the drug, you must consult your doctor.

Among the analogues of Ibuprofen are:

• Deep Relief;
• Nurofen;
• Diclofenac;
• Ibuprom;
• Solpaflex;
• ArthroCam;
• Faspik.

Ibuprofen is a very effective and inexpensive drug that can quickly eliminate inflammation and pain. However, you should be aware of contraindications and side effects that may occur with uncontrolled use of the medicine.

Instructions for use

Each dosage form of Ibuprofen requires proper use and compliance with certain dosages. Only in this case will the medicine be as effective as possible and quickly help cope with the existing illness.

In tablet form

In this form, Ibuprofen is taken after meals. The only exception is the first dose of the drug, taken before breakfast. The tablet should be swallowed whole and washed down with plenty of water warmed to room temperature. It is prohibited to crush the medicine in any way, as this may reduce its effectiveness.

Instructions for use of Ibuprofen tablets for adults (over 12 years of age) provide for daily use of the medicine in the amount of 3 or 4 tablets. The maximum daily dose is 1.2 grams (6 tablets). The entire daily norm is evenly distributed over the entire waking period. The break between tablets should be at least 4 hours. After achieving positive dynamics, it is necessary to gradually reduce the amount of Ibuprofen used.

The duration of the course of treatment is determined by the doctor. In most cases, it is limited to 5 days, but in the absence of any side effects it can be extended. The maximum duration of taking Ibuprofen tablets is 2 weeks. Over the next month, it is prohibited to use not only this drug, but also any other non-steroidal anti-inflammatory drug.

Since Ibuprofen is considered a weak medicine, it can also be taken by children. In this case, the daily dose is limited to 2 or 3 tablets. It is prohibited to use the product to treat children whose body weight is less than 20 kg. The break between doses of the medicine should be at least 6 hours.

Ointment or gel

Ointment or gel

The procedure for applying the gel and ointment requires additional steps that will help increase the effectiveness of the drug and cure the patient as soon as possible. Patients over 12 years of age need to squeeze a strip of gel up to 10 centimeters long onto the affected area. After this, you should gently rub it into the skin. This can be done using simple low-intensity rotational movements.

In childhood, a halved dose of medication should be used. It can be used no more than 3 times a day. The duration of treatment for all age categories is the same and is approximately 3 weeks. If repeated therapy is necessary, a pause of 2 months should be maintained.

As a suspension

In most cases, this pharmaceutical form is used to treat children. It has a pleasant taste, which greatly simplifies the intake process. In standard situations, you should give the child 5 to 10 grams of the drug per kilogram of weight. The calculated dosage is divided into 3 doses and drunk by the patient after meals.

It is best to give Ibuprofen syrup to babies under 1 year of age only after consultation with a pediatrician. During the entire period of use, it is necessary to monitor changes and vary the dosage. The maximum daily dose of the drug for young patients is 10 milliliters per day. It is divided into 4 servings and given to the baby throughout the day.

Rectal suppositories

This form of medication is used quite rarely, but it helps to effectively resist fever and pain of various origins. The dosage is prescribed by the attending physician and is selected based on the following criteria:

• patient's age;
• body mass;
• pain intensity;
• degree of complexity of the disease.

In one procedure, you can use up to 10 milligrams of the drug per kilogram of weight. The frequency of use is 3 times a day, and the maximum daily dose is 300 mg/kg.

Amount of drug for treating children:

1. With a weight of 5.5 to 8 kg and an age of up to 9 months. For this category of patients, 1 suppository should be administered every 8 hours.
2. From 8 to 12.5 kilograms and up to 2 years of age. These children need to be administered 1 suppository 4 times a day.
3. Body weight more than 12.5 kg and age over 2 years. They should use 2 suppositories 3 times a day.

At what age is it allowed to take it?

In case of acute respiratory viral infection, pediatricians recommend using Ibuprofen syrup for children to relieve fever and pain. Instructions for use prescribe this drug for patients aged 3 to 12 years. In some cases, for joint, muscle and toothache, the medicine is given to children over 3 months old. Patients over 6 years of age can take the drug with the same active ingredients, but in the form of granules for the preparation of tablets and syrup.

Ibuprofen in tablet form is not prescribed to children under 6 years of age. If a child has reached the age of six, but weighs less than 20 kg, a drug with a dosage of 200 mg of active ingredient per tablet is also not prescribed.

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The suspension is not prescribed to infants under 3 months of age, and to children 3-6 months old it can only be given after consulting a doctor (most often at this age the drug is prescribed for post-vaccination fever). The annotation for the medicine also states that it is prescribed only up to 12 years of age, and for adolescents over 12 years of age it is better to give analogues with a higher dosage.

Ibuprofen is contraindicated in children under 3 months of age. For three-month-old toddlers, the medicine is prescribed in the form of suppositories or suspension. In this case, it is recommended to use suppositories up to 2 years of age, and suspensions up to 12 years of age. In addition, the prescription of medication to babies 3-6 months old must be supervised by a pediatrician.

The solid form is not used in children under 6 years of age or in older children weighing less than 20 kg. Such restrictions apply to tablets and capsules containing ibuprofen at a dose of 200 mg. The drug with a dosage of 400 mg per tablet is prescribed to adolescents 12 years of age and older. The use of 5% gel is recommended from the age of 6, and 5% ointment - only from the age of 12.

Nurofen

The first analogue of Ibuprofen is Nurofen. The cost of the drug is within 200 rubles.

The product contains the same active substance – ibuprofen. Nurofen also contains various auxiliary components, which may differ depending on the form of release. For example, the tablets contain substances such as stearic acid, croscarmellose sodium, sucrose, sodium lauryl sulfate and others.

Nurofen is available in the following forms:

• pills;
• syrup;
• rectal suppositories;
• capsules;
• gel.

This analogue of Ibuprofen can also be used to treat children (Nurofen suspension). There are also special forms of the drug that have a shorter duration of action and an increased level of effectiveness - “Nurofen Express” and “Nurofen Express Neo”.

Indications for use of the Ibuprofen analogue are the same as for the main drug.

"Brufen"

The drug is available in the form of tablets and syrup. Its main active ingredient is ibuprofen.

"Brufen" has a wide spectrum of action and is used for:

• rheumatoid arthritis;
• osteoarthritis;
• rheumatism;
• pain due to damage to ligaments, soft tissues, tendons;
• muscle pain;
• menstrual pain in women;
• toothache;
• migraines;
• fever;
• various inflammatory processes.

Not used to treat children weighing up to 7 kilograms and pregnant women.

Release form and composition

Ibuprofen is sold in the form of tablets, rectal suppositories, suspension and gel.

The tablets are produced in blister packs (10 tablets each), placed in cardboard packs of 2 or 5 pieces.

Rectal suppositories are produced in blister packs (5 suppositories each), placed in cardboard packs of 2 pcs.

The gel is produced in aluminum tubes (20, 30, 50 or 100 g of the drug), placed in cardboard packages of 1 pc.

The oral suspension for children is available in polymer or glass bottles (100 ml of the drug each), placed in cardboard packages of 1 pc. The set includes a measuring cup or spoon.

100 ml of oral suspension for children contains 2 g of ibuprofen and excipients: polysorbate, sodium saccharinate, citric acid monohydrate, glycerol, sorbitol (sorbitol), xanthan gum, sodium chloride, methyl parahydroxybenzoate, propyl parahydroxybenzoate, orange flavor, purified water.

Composition, physical and chemical characteristics, price

Ibuprofen is available in several dosage forms, which are intended for oral, cutaneous and rectal administration.

Ibuprofen gel analogues

The medicine in the form of a gel has proven itself in the treatment of pain and inflammatory processes in soft tissues and joints. Ibuprofen and its analogues are prescribed for bursitis and arthritis. The big advantage of the gel over tablets is that it enters the bloodstream, bypassing the gastrointestinal tract.

Dolgit

Dolgit is produced in two dosage forms: a gel with ibuprofen and a cream for external use. The concentration of ibuprofen in these forms is the same, the difference lies in the additional components that are used to make the gel and cream. Thanks to the external method of use, Dolgit gel helps reduce pain in the affected area, as well as reduce tissue swelling, and prevent further development of the inflammatory process. Ibuprofen gels are most often used for one-time or seasonal relief of rheumatic pain.

With its help, it is possible to quickly reduce pain at the site of application for gout, radiculitis, sciatica, lumbago, osteoarthritis, periarthritis, arthritis and other pathologies of the musculoskeletal system. In addition, the product can be used to relieve pain from various household injuries, sports or industrial injuries to soft tissues.

The cost of Dolgit gel is 150 rubles. average.

Nurofen

Nurofen contains ibuprofen, so the drug is a complete substitute for the original product. An ibuprofen ointment called Nurofen can have the same effects as the original substance. With local application, the substance is evenly and quickly distributed in the area of ​​inflammation. This reduces pain and swelling, as well as a feeling of stiffness in the joints.

Nurofen in gel form has fewer side effects. The drug is well tolerated

It is important to remember that the product should not be used by children under 12 years of age and patients prone to allergies.

The cost of Nurofen gel is 150–350 rubles.

Ketonal

A substitute for Ibuprofen, which contains the active substance called ketoprofen. With the help of this component, pain, inflammation and swelling in the affected area are reduced. According to the instructions and description of pharmacotherapeutic properties, ketoprofen is not able to have a negative effect on the condition of articular cartilage.

Ketonal is indicated for rheumatoid arthritis, myalgia, neuralgia, bursitis, radiculitis and injuries of the musculoskeletal system. Not recommended for children under 12 years of age and pregnant women. The drug is non-toxic, but it should not be used by people with allergies.

The cost of the product is 270 rubles.

Terms of sale and storage

Ibuprofen suspension is an over-the-counter medication and is therefore sold without a prescription, but it is still advisable to consult a pediatrician before using this product on a child (especially those under 2 years of age). The average price of a 100-ml bottle is 60-70 rubles.

It is recommended to store the sealed drug at home at room temperature throughout the entire shelf life (3 years) - in a dry place where the product cannot be reached by small children. If the package is opened, it should be used within 6 months.

All versions of Ibuprofen are products sold in pharmacies without a prescription. The price of the medicine depends on both the manufacturer and the form of the drug. For example, 10 suppositories or 100 ml of suspension costs an average of 60-70 rubles, and the price of tablets is much lower and often amounts to about 20 rubles for 20 pieces.

It is recommended to keep any form of Ibuprofen at home in a place hidden from small children, away from moisture and sunlight. Storing the drug in tablets, capsules, suppositories, gel or suspension is allowed at room temperature, and the ointment should be kept in a cool place (at a temperature below 15 degrees). The shelf life of tablets is 3 years, all other forms are 2 years. Once opened, the suspension should be stored for no longer than six months.

Pharmacodynamics and pharmacokinetics

Pharmacological properties

Pharmacodynamics. It has an analgesic, anti-inflammatory and moderate antipyretic effect due to inhibition of prostaglandin biosynthesis by inhibiting the enzyme cyclooxygenase. Suppresses platelet aggregation. Does not affect blood clotting factors. Bleeding time increases slightly. Relieves pain, incl. joint pain at rest and with movement; reduces morning stiffness and swelling of joints, promotes increased range of motion.

Pharmacokinetics. Well absorbed from the digestive tract when administered orally (80%). Simultaneous food intake slows down absorption, but does not affect its volume. The maximum concentration in blood plasma is 1-2 hours, in synovial fluid - 3 hours. In children, the maximum concentration in the blood is reached after 2-4 hours, and the hypothermic effect develops 1 hour after administration. Half-life (T ½) is 2-4 hours, binding to plasma proteins is 90-99%. Slowly penetrates into the joint cavity, lingers in the synovial tissue, in which it forms concentrations higher than in plasma. To achieve the full anti-inflammatory effect, it takes from several days to 2 weeks of systematic use of ibuprofen. Biological activity is associated with S-enantiomir. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized and excreted in the urine (no more than 1% unchanged) and, to a lesser extent, in bile. Not found in breast milk. It is completely eliminated from the body within 24 hours.

Restrictions on taking the drug and complete contraindications

The medication "Ibuprofen" for pain and fever is not prescribed if there is hypersensitivity to the components. Also, the medicine is not recommended for use for certain diseases of the intestines and stomach, in particular ulcers and colitis. However, it is worth noting that this limitation applies only to the form of suspension and tablets. In addition, any form of medication is not used for certain eye diseases and visual impairment, during exacerbation of kidney and liver diseases. The medicine is not prescribed to patients with impaired blood pressure and heart function. If non-steroidal anti-inflammatory drugs cause bronchospasm and provoke asthma, then this drug is also prohibited for use.

The composition is prescribed with extreme caution during pregnancy and lactation. In these situations, the period of fetal development, as well as the age of the born baby, is taken into account.

Reviews about the drug "Ibuprofen" say that in such cases it is worth using the children's dosage. Medicine in tablets is not recommended for children under 12 years of age. Advantage should be given to the suspension. Also, many diseases of the digestive tract in the anamnesis may become a reason for particularly careful monitoring of the patient’s health when treated with Ibuprofen.

Other medicines

However, Ibuprofen has the ability to interfere with many other medications, such as glucocorticoids, other pain medications, diuretics, or anticoagulants. Therefore, such a drug should be prescribed together with any other drugs with caution. You should combine Ibuprofen with other antipyretics or alternate them only after consulting your doctor.

The use of Ibuprofen may interfere with the treatment of many other drugs, including other non-steroidal drugs, diuretics, insulin, vasodilators, antacids and anticoagulants. If your child is taking any additional medications, you should consult your doctor before taking the suspension.

Ibuprofen should be used with extreme caution with other non-steroidal anti-inflammatory drugs. Also, you should not combine it with hormonal drugs, as this may increase the risk of internal bleeding. Doctors do not recommend using Ibuprofen together with cardiac glycosides and aspirin.

In addition, the drug in question can reduce the diuretic effect of drugs such as Furosemide. In turn, diuretics increase the nephrotoxicity of non-steroidal anti-inflammatory drugs. If you take Ibuprofen together with thrombolytic drugs, their effect will be enhanced.

• It is not recommended to take ibuprofen with simultaneous treatment with other NSAIDs;
• When prescribed with anticoagulants, the risk of bleeding increases;
• When interacting with serotonin reuptake blockers, the risk of bleeding from the gastrointestinal tract increases;
• With simultaneous treatment with cephalosporins, the frequency of hypoprothrombinemia increases and the risk of nephro- and hepatotoxic effects increases;
• When treated with inducers of microsomal oxidation, the risk of intoxication increases;
• Barbiturates and drugs with ethanol increase the concentration of ibuprofen in the blood plasma;
• Reduces the effect of vasodilators, furosemide and hydrochlorothiazide;
• Increases the activity of antiplatelet agents, indirect anticoagulants, fibrinolytics, hypoglycemic drugs and insulin, sulfonylurea derivatives;
• Cholestyramine and antacids reduce the absorption of ibuprofen;
• Caffeine enhances the pain-relieving effect of ibuprofen.

Check with your doctor or pharmacist before using any other product, including vitamins and herbal products.

Some medications may interact with ibuprofen.

In particular, it is recommended to refrain from taking:

• lithium
• methotrexate
• anticoagulants (warfarin) and antiplatelet agents (acetylsalicylic acid)
• corticosteroids
• diuretics
• antihypertensive drugs (ACE inhibitors)

It is not recommended to use other NSAIDs at the same time without your doctor's consent. Examples of other NSAIDs are aspirin, diclofenac, naproxen.

You should not drink alcohol while taking the drug because it may increase the risk of stomach bleeding.

All children's single medications based on Ibuprofen are similar in release forms, dosages and rules of administration. But there may be nuances, so you need to carefully read the instructions every time.

https://www.youtube.com/watch?v=ytadvertiseen-GB

The child’s body has two watchdogs – temperature and pain. Ibuprofen calms these two angry dogs. But who then will warn us about the danger? If a child does not feel well or has any alarming symptoms, there is no need to suppress all this with the maximum permissible doses of an antipyretic.

Remember that this is not a treatment, but only an auxiliary symptomatic therapy. Ibuprofen does not affect the cause of the disease. If with a viral infection there is no particular need to influence this cause, then with a bacterial infection, “silencing” the signs of the disease with ibuprofen can lead to a state of such neglect of the pathology that the child will have to be rescued in intensive care.

What is better Ibuprofen or analogues

It is impossible to give an exact answer to this question. On the one hand, the cost of Ibuprofen is much lower in comparison with other drugs with the same active substance or a similar type of action. At the same time, the product is highly effective and has a fairly wide spectrum of action, quite rarely causes side effects, and is available in several forms.

But, on the other hand, in some cases it may still be necessary to find an alternative option. For example, analogues of Ibuprofen are used when the desired effect does not occur after using the original drug. They also look for a replacement in cases where a certain form of medicine is needed (syrup, gel, suppositories, etc.) or the medicine is simply not available in the pharmacy.

You should not rely on other people’s experience in trying to find the answer to the question: “Which drug is better?” After all, each person has his own unique body, and medications also affect him differently. That is why Ibuprofen is a great help for some, while others are forced to buy more expensive imported medicines. Be that as it may, the selection of non-steroidal anti-inflammatory drugs should be done by a doctor.

Do not self-medicate and be healthy!

Action and composition of the drug

The drug contains one active ingredient - ibuprofen. Liquid for internal use, approved from six months of age, contains 100 mg of the active substance, Ibuprofen-Akrikhin suspension (approved from 3 months of age) contains 200 mg.

The additional components of both types of suspension are the same, but their concentrations are different. Additional substances of the drug:

• solution of sodium hydroxide and hydrochloric acid;
• lemon acid;
• xanthan gum;
• sodium saccharin;
• polysorbate;
• orange flavor;
• methyl parahydroxybenzoate;
• glycerol;
• purified water;
• propyl parahydroxybenzoate.

Children's suspension belongs to the group of non-steroidal anti-inflammatory drugs. The active ingredient ibuprofen is a derivative of propionic acid. It has anti-inflammatory, antipyretic, analgesic effects. It inhibits COX-1, COX-2 and prostaglandin synthesis. The effect of the drug occurs after 45 minutes when taken on an empty stomach, or after 1.5–2 hours when taken with food. Ibuprofen is well absorbed from the gastrointestinal tract.

Contraindications

• erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
• renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease;
• confirmed hyperkalemia;
• hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
• in the period after coronary artery bypass surgery;
• pregnancy (III trimester);
• inflammatory bowel diseases in the acute phase, incl. ulcerative colitis;
• anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or another non-steroidal anti-inflammatory drug (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
• liver failure or active liver disease;
• children's age: up to 6 years and from 6 to 12 years (with body weight less than 20 kg) - for tablets 200 mg; up to 12 years – for tablets 400 mg;
• hypersensitivity to any of the ingredients included in the drug.

With caution: elderly age, congestive heart failure, cerebrovascular disease, arterial hypertension, coronary heart disease, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, nephrotic syndrome, CC less than 30-60 ml/min, hyperbilirubinemia, gastric and duodenal ulcers intestines (history), presence of Helicobacter pylori infections, gastritis, enteritis, colitis, long-term use of NSAIDs, blood diseases of unknown etiology (leukopenia and anemia), pregnancy (I-II) trimester, lactation period, smoking, frequent alcohol consumption (alcoholism) , severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid; clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline )

Use during pregnancy and breastfeeding

The annotation for the drug states that it is not recommended to treat women during breastfeeding and pregnancy with Ibuprofen, but doctors still sometimes prescribe this drug in some trimesters of pregnancy and for nursing mothers. What is the reason for this ambiguity? The fact is that a gynecologist can give permission to use the drug if the risk to the health of the mother and child does not exceed the expected benefit from using Ibuprofen. For example, during breastfeeding and in the third trimester of pregnancy, the doctor may prescribe a one-time dose of medication if the body temperature rises and acute pain develops. At the same time, we must not forget that the active substances of the drug can penetrate into milk and, therefore, enter the baby’s body, causing significant harm and side effects. It has been proven that the drug can provoke negative manifestations in children under 6 years of age and negatively affect the child’s body, therefore, if possible, it is better to avoid taking Ibuprofen during lactation.

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In addition, the instructions for use indicate that a woman should not be treated if there is a threat of miscarriage. At the same time, it is necessary to bring down the temperature and reduce pain using alternative means. You can use drugs that are approved for pregnant women in all trimesters.

special instructions

Before you start taking Ibuprofen tablets, you must carefully read the instructions for the drug.

There are a few special instructions that you should pay attention to before using it, these include:

• Treatment must be carried out in the minimum effective dose and in a short course, which should not exceed 5 days.
• In case of long-term use of Ibuprofen tablets, periodic laboratory monitoring of the functional activity of the liver, kidneys, and blood clotting is necessary.
• Concomitant use with other drugs from the pharmacological group of non-steroidal anti-inflammatory drugs is not recommended.
• If laboratory determination of the level of ketosteroids in the blood is necessary, 48 hours before the test, the drug is discontinued, since its use may affect the reliability of the results.
• For children aged 6 to 12 years, the drug can only be used under the supervision of a doctor.
• While taking the drug, it is recommended to refrain from activities that require increased concentration and speed of psychomotor reactions.

Interaction with other drugs

Concomitant use of Ibuprofen CAPS with acetylsalicylic acid (aspirin) is not recommended unless low-dose aspirin (not exceeding 75 mg per day) is recommended by your doctor, as it increases the risk of adverse side effects. When taken concomitantly, ibuprofen may inhibit the effect of low-dose aspirin on platelet aggregation.

You should also avoid taking two or more NSAIDs at the same time, including selective cyclooxygenase-2 inhibitors, as this may increase the risk of side effects.

When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia.

Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an increased risk of nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

NSAIDs should not be used for 8 to 12 days after taking mifepristone because NSAIDs may reduce the effect of mifepristone.

Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.

When NSAIDs and zidovudine are taken concomitantly, the risk of hematological toxicity increases.

Patients taking NSAIDs and quinolones have an increased risk of seizures.

Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity.

Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.

Increases the side effects of mineralcorticosteroids, glucocorticosteroids, estrogens, ethanol.

Enhances the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin. Antacids and cholestyramine reduce absorption.

Increases the blood concentration of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Side effects

If you use Ibuprofen incorrectly and do not follow the dosage, you may experience various side effects. They will not only complicate the treatment process, but will also entail additional financial costs.

Mistakes in using Ibuprofen can lead to the following consequences:

1. Digestive system. The gastrointestinal tract suffers most from taking pills. Because of them, gastropathy may develop, accompanied by pain in the stomach, attacks of nausea and vomiting. In addition, appetite decreases, dry mouth, heartburn, and severe diarrhea appear. In the most severe cases, ulcers may begin to form on the stomach lining, leading to bleeding.
2. Nervous system. Due to improper medication use, severe headaches, dizziness, and drowsiness are observed. In addition, depression occurs, irritability increases, hallucinations and confusion.
3. The cardiovascular system. Excessive dosages of Ibuprofen can lead to the development of heart failure, tachycardia, and an increase in blood pressure.
4. Sense organs. Some patients who took Ibuprofen complained of tinnitus, decreased hearing and vision, and swelling of the eyelids. In addition, doctors diagnosed conjunctivitis, diplopia and toxic damage to the optic nerve.
5. Circulatory system. Sometimes anemia (decreased number of red blood cells) and thrombocytopenia (decreased concentration of platelets in the blood) may occur.
6. Urinary system. The main side effect is the possibility of developing kidney failure. Other problems include cystitis, polyuria, allergic nephritis, and nephrotic syndrome.
7. Allergic reactions. Due to the incorrect dosage of Ibuprofen, a rash may appear on the surface of the skin, accompanied by severe itching. In addition, angioedema, urticaria, anaphylactic shock and bronchial asthma occur. In severe cases, doctors record the formation of Lyell and Stevens-Johnson syndrome.

Side effects

• Gastrointestinal tract: gastropathy phenomena, expressed by abdominal pain, dry mouth, heartburn, nausea, vomiting, loss of appetite, diarrhea, flatulence, constipation. Occasionally, ulcerations of the mucous membrane of the stomach and intestines occur, with possible, extremely rare complications in the form of bleeding and perforation, as well as pancreatitis (these reactions are most likely with long-term treatment). On the part of the liver, hepatitis may develop.
• Respiratory organs: bronchospasm, shortness of breath.
• Sense organs: decreased hearing, ringing or noise in the ears, blurred vision, double vision, dry cornea, swelling of the eyelids and conjunctiva.
• Central and peripheral nervous system: dizziness, headache, sleep disturbance, irritability, confusion, depression, psychomotor agitation. In rare cases, people with autoimmune pathologies develop aseptic meningitis.
• Cardiovascular system: hypertension, heart failure, tachycardia.
• Excretory system: allergic type nephritis, acute renal failure, edema, cystitis, polyuria.
• Allergic reactions, which are also typical for external forms: skin rash such as erythema and urticaria, tingling, Quincke's edema, itching of the skin. Rarely - anaphylactic shock, exudative erythema multiforme, bronchospasm, allergic rhinitis, eosinophilia.
• Hematopoietic system: anemia, agranulocytosis, thrombocytopenic purpura, thrombocytopenia and leukopenia.
• Other reactions – increased sweating.

Laboratory indicators:

• Increased: bleeding time, serum creatinine concentration, liver transaminase activity.
• Decrease in: concentrations of glucose, hemoglobin, hematocrit, creatinine clearance.

Overdose

When the dose of the drug for internal use is significantly exceeded, the following symptoms develop: epigastric pain, drowsiness, vomiting, headache, tinnitus, metabolic acidosis, coma, drop in blood pressure, tachycardia, atrial fibrillation. Treatment is inpatient.

Instructions for use Ibuprofen method and dosage

Pills

Taken orally. Prescribed to children over 12 years of age and to adult patients orally, 3-4 times a day. To obtain a rapid therapeutic effect, the dose of the drug can be increased to 400 mg (2 tablets) 3 times a day. Next, the daily dose of Ibuprofen is reduced to 600-800 mg. It is recommended to take the morning dose before meals with water (for faster absorption of the drug). The remaining doses are taken during the day after meals.

The maximum permissible daily dose is 1200 mg (no more than 6 tablets in 24 hours). A repeat dose should be taken no more often than after 4 hours. The duration of use of the tablets is no more than 5 days.

Children from 6 to 12 years old are prescribed 1 tablet. no more than 4 times a day. Ibuprofen can only be used if the child's body weight is more than 20 kg. The break between taking the drug should be at least 6 hours (daily dose no more than 30 mg/kg).

Rectal suppositories

The dosage depends on the age and body weight of the child. A single dose of Ibuprofen is 5-10 mg/kg body weight 3-4 times a day. The maximum daily dose should not exceed 30 mg/kg body weight per day.

Children aged 3-9 months (with body weight from 5.5 kg to 8.0 kg) are prescribed 1 supp. (60 mg) 3 times a day, with an interval of 6-8 hours. The maximum dose is no more than 180 mg per day.

Children aged 9 months to 2 years (with body weight from 8.0 kg to 12.5 kg) are prescribed 1 supp. (60 mg) 4 times a day, with an interval of 6 hours. The maximum dose of the drug is no more than 240 mg per day.

For post-immunization fever, children under 1 year of age are prescribed 1 suppository, after 1 year - an additional suppository after 6 hours. The duration of therapy depends on the purpose of use of the drug.

Oral suspension

The dosage regimen is set individually, depending on the severity of the clinical manifestations of the disease. For adult patients, a single oral dose is 200-800 mg, with a frequency of 3-4 times a day. The maximum daily dose is 2.4 g.

For children - 20-40 mg/kg body weight per day in several doses. The duration of external use of the drug is 2-3 weeks.

Gel

For children over 12 years of age and adult patients, a strip of gel 4-10 cm long is applied to the affected area and rubbed in with light movements until absorbed. Repeated use of Ibuprofen is possible only after 4 hours and no more than 4 times a day. For children from 6 to 12 years old, a strip of gel 2-4 cm long is applied to the affected area (no more than 3 times a day). Duration of therapy is 2-3 weeks.

Mode of application

Ibuprofen in tablet and capsule form

Tablets and capsules are taken orally with the required amount of liquid during meals or in the first 15-30 minutes after meals. Depending on the severity of the signs of the disease and the presence of concomitant conditions, as well as the patient’s weight, Ibuprofen can be prescribed in a dosage of 200 to 800 mg 1-4 times a day. The course of treatment is prescribed individually, and can vary from a single dose for short-term and mild pain, to 7-10 days for pronounced exacerbations of chronic diseases.

Ibuprofen in suspension form

Ibuprofen suspensions are conveniently administered to children during meals or within 15-30 minutes after meals. The calculation of the drug depends on the child’s weight: 5-10 mg per kg of weight per dose. The maximum daily dosage is 20-30 mg per kg of patient weight. According to average calculations, at the age of 3-6 months it is recommended to give 2.5 ml per dose, up to 3 times a day; at 6 months – 1 year – 2.5 ml, up to 4 times a day; in 1-3 years – 5 ml per dose, up to 3 times a day; at 4-6 years old – 7.5 ml up to 3 times a day; at 7-9 years old – 10 ml up to 3 times a day; at 10-12 years old – 15 ml up to 3 times a day. After 12 years and in adulthood - 20-40 ml per dose, up to 3-4 times a day. The course of treatment ranges from a single dose to 10 days, on average 5-7 days.

Ibuprofen in gel or ointment form

Ibuprofen gel or ointment is applied externally to the skin, in the projection area of ​​the affected area of ​​the spine, in a thin layer, rubbing in a little, 3-4 times a day. After the intensity of symptoms decreases, the frequency of application can be reduced to 2 times a day. The duration of the course of therapy is on average 10-30 days.

Ibuprofen tablets instructions for use dosage for adults

Appearance of Ibuprofen tablets

The daily dose of the drug depends on the disease:

• For osteoarthritis, algodismenorrhea, psoriatic arthritis and ankylosing spondylitis, adults are prescribed 400-600 mg 3-4 times a day;
• For rheumatoid arthritis, take an increased dose, 800 mg 3 times a day;
• For soft tissue injuries and sprains, long-acting Ibuprofen tablets are used - 1600-2400 mg once a day, preferably before bedtime;
• For moderate pain, take 1200 mg per day;
• For febrile syndrome that occurs after immunization, use 50 mg; if necessary, the dose can be repeated after 6 hours, but not more than 100 mg per day.

For febrile conditions in children over 12 years of age, to reduce body temperature, the dose of Ibuprofen is calculated:

• Above 39.2 degrees C – 10 mg per 1 kg of weight per day;
• Below 39.2 degrees C – 5 mg per 1 kg of weight per day.

Ibuprofen lozenges are used to treat ENT diseases by dissolving in the mouth under the tongue. Children over 12 years of age and adults are prescribed 200–400 mg 2–3 times a day.

Oral suspension is usually prescribed to children. The average single dose when taken 3 times a day is:

• From 1 to 3 years – 100 mg;
• From 4 to 6 years – 150 mg;
• From 7 to 9 years – 200 mg;
• From 10 to 12 years – 300 mg.

Apply Ibuprofen gel or cream externally, applying and rubbing it until completely absorbed onto the affected area 3-4 times a day. Treatment can be carried out for 2-3 weeks.

Dosage

Taking medication in doses above the maximum permissible is characterized by:

• abdominal pain;
• nausea, vomiting;
• headache;
• tinnitus;
• bradycardia;
• tachycardia;
• acute renal failure;
• stopping breathing.

In case of overdose it is recommended:

• perform gastric lavage (only during the first hour after taking the medicine);
• take activated carbon at the rate of 1 tablet per 10 kg of body weight;
• alkaline drink (alkaline mineral water - Essentuki, Borjomi, weak soda solution - take 10 grams of baking soda for 1 liter of drinking water).

Overdose

Children who take more than 400 mg/kg may experience overdose symptoms. In adults, the dose-response relationship is less clear. The half-life in case of overdose is 1.5 - 3 hours.

Symptoms: in most patients: nausea, vomiting, epigastric pain, less often diarrhea. Tinnitus, headache and gastrointestinal bleeding may occur.

In more serious poisonings, toxicity to the central nervous system occurs in the form of drowsiness, sometimes agitation and disorientation or coma. Sometimes patients develop seizures.

In severe cases, metabolic acidosis may occur and prothrombin time increases, which is likely due to interference with circulating coagulation factors. Acute renal failure and liver damage, exacerbation of asthma in asthmatics, may occur.

Treatment: should be symptomatic and supportive. Includes maintaining the airway and monitoring cardiac and vital signs until stabilization. During the first hour after taking the drug, gastric lavage and intake of activated charcoal. In case of frequent and prolonged seizures, it is necessary to use anticonvulsants (diazepam or lorazepam); for asthmatics, bronchodilators.

Dosage and use of the drug

The gel is used only externally for application to the skin. It is recommended to apply a small amount of gel from 5 to 10 cm to the inflamed area and rub it in until it is completely absorbed. You need to reapply the product no earlier than 4 hours and no more than 4 times a day.

The amount of gel depends on the size of the affected area:

• rheumatoid arthritis 700 mg gel three times a day;
• spondylitis and osteoarthritis 500 – 700 mg Ibuprofen three or four times a day;
• for injuries 600 mg gel twice a day;
• for severe pain 500 mg.

The dosage of the gel per day is 2.4 grams and no more.

Features of Ibuprofen gel:

• the active substance penetrates deeper into the tissue;
• the effect occurs twice as fast;
• does not cause harm to the body;
• has a double cooling effect;
• is a hygienic product.

Side effects:

• nausea;
• vomiting reflex;
• constipation;
• intestinal disorder;
• bloating;
• migraine;
• sleep disturbance;
• allergies;
• decreased vision;
• stomach bleeding;
• bronchospasm;
• edema;
• burning of the skin.

Interaction

Anti-inflammatory, antipyretic, analgesic.

The annotation for dosage forms for oral use and rectal suppositories lists the following side effects:

• NSAID gastropathy, dryness, irritation and/or ulceration of the oral mucosa, pain in the mouth, pancreatitis, aphthous stomatitis;
• hepatitis;
• bronchospasm, shortness of breath;
• noise/ringing in the ears, hearing loss;
• double vision or decreased clarity of visual images, irritation and dry eyes, toxic damage to the optic nerve, scotoma, swelling of the eyelids, swelling of the conjunctiva;
• nervousness, headache, anxiety, confusion, insomnia/drowsiness, dizziness, mental and motor agitation, hallucinations, depression, aseptic meningitis (rare and mainly in patients with autoimmune diseases);
• decreased contractility of the heart muscle, increased blood pressure, tachycardia; acute renal failure, polyuria, nephrotic syndrome, allergic nephritis, cystitis;
• hypersensitivity reactions;
• anemia, thrombocyto- and leukopenia, Werlhof's disease, agranulocytosis;
• increased sweating.

The likelihood of visual impairment, development of gastric/intestinal bleeding and ulceration of the walls of the digestive canal increases with long-term use of high doses of Ibuprofen.

The drug affects laboratory parameters, namely:

• increases bleeding time;
• reduces serum glucose concentration, Clcr, hematocrit number and hemoglobin level;
• increases the activity of liver transaminases;
• increases the concentration of creatinine in the blood serum.

Side effects when applied topically in gel/ointment form:

• tingling/burning sensation;
• skin hyperemia.

With long-term use of external therapy, the systemic effects inherent in all NSAIDs may develop.

Drugs that induce microsomal oxidation increase the production of hydroxylated active metabolic products and thus increase the risk of developing serious hepatotoxic reactions. Drugs that inhibit microsomal oxidation, on the contrary, reduce it.

Ibuprofen reduces the sodium and diuretic activity of hydrochlorothiazide and furosemide, the effectiveness of antihypertensive and uricosuric drugs (including ACE inhibitors and BMCC), and the antiplatelet and anti-inflammatory effects of ASA.

Potentiates the effect of antiplatelet agents, indirect anticoagulants, fibrinolytics, insulin and oral forms of hypoglycemic drugs, ulcerogenic effect with bleeding of GCS and MCS.

Absorption of the drug is reduced in combination with cholestyramine and antacids. Caffeine enhances the analgesic effect. In combination with thrombolytics and anticoagulants, it increases the risk of bleeding.

Cefotetan, Cefoperazone, Cefamandole, Plicamycin and valproic acid increase the incidence of prothrombin (clotting factor) deficiency in the blood.

Myelotoxic drugs enhance the hematotoxicity of Ibuprofen. The drugs Au and Cyclosporine enhance the effect of the drug on the synthesis of Pg in the kidneys, resulting in increased nephrotoxicity. In turn, Ibuprofen increases the concentration of cyclosporine in the blood plasma and its hepatotoxicity.

Drugs that block tubular secretion increase the concentration of ibuprofen in the blood plasma and reduce its excretion.

Ibuprofen is the drug of choice for pain and fever during pregnancy, since during this period of time it is safer for the woman’s body than most other analgesics and antipyretics.

In the first 2 trimesters of pregnancy, it does not have a negative effect on the development of the fetus, does not provoke bleeding (unlike aspirin) and does not create a threat of miscarriage.

In the last trimester of pregnancy, taking Ibuprofen is contraindicated.

Firstly, the drug inhibits the contraction of the uterine muscles. Secondly, its use can cause closure of the ductus Botallus and the development of pulmonary hypertension in a child. Thirdly, the medicine tends to block the hormones responsible for the birth process.

Ibuprofen during breastfeeding does not affect the quality and secretion of milk, therefore it can be used to treat nursing women.

If the medicine is used correctly, the dosage and frequency of administration prescribed by the doctor are followed, Ibuprofen rarely causes side effects. However, it is impossible to completely exclude the possibility of their occurrence. The following side effects are distinguished depending on the affected system:

1. From the digestive system: abdominal pain, nausea, vomiting, heartburn, loss of appetite, flatulence, diarrhea, gastrointestinal ulcers.
2. From the respiratory system: bronchospasm, shortness of breath.
3. Damage to the sense organs: hearing loss, visual impairment, periodic tinnitus, impaired visual perception, swelling of the eyelids and conjunctiva.
4. From the nervous system: headache, dizziness, insomnia, anxiety, depression, confusion.
5. Disorders of the cardiovascular system: heart failure, tachycardia, increased blood pressure.
6. Disorders of the urinary system: acute renal failure, allergic nephritis, edema, cystitis, polyuria.
7. Allergic reactions: skin rash, itching, angioedema, anaphylactic shock, bronchospasm or apnea.
8. Disturbance of the hematopoietic system: anemia, thrombocytopenia, agranulocytosis, leukopenia.

Is it allowed to take during lactation?

The use of Ibuprofen during feeding is allowed due to its mild effect. The only point is that it is allowed to use the medicine during lactation if there are no contraindications.

The medicine does not affect breast milk in any way. A minimal amount of the drug penetrates into it. There is no evidence that the active substance has a negative effect on the fetus. During lactation, Ibuprofen only acts to lower the temperature, block pain, inflammation, and not on the mother’s body.

The bioactive substance is completely absorbed after 1.5 hours. After 2 hours, the half-life of the main active ingredient begins. Therefore, it is better for a nursing mother to take the pill immediately after lactation.

It should be remembered that breastfeeding can be done even if a woman has a high temperature. The milk will not curdle or sour in the breast. The only thing is that it can be a little bitter if the temperature is high for a long time. But while taking Ibuprofen, the effect of those same prostaglandins will be controlled by the medicine, and the milk will remain sweet and tasty for the child. Therefore, if the mark on the thermometer reaches 380 while breastfeeding, it is recommended to take Ibuprofen so as not to torment yourself with illness and not starve the baby.

Conditions for dispensing from pharmacies

You can purchase the drug at any pharmacy without a prescription from a doctor. It is cheaper to buy online, but it is important to use only trusted resources and official pharmacy websites, because due to the popularity of Ibuprofen, cases of counterfeits have become more frequent. The drug should be stored at a temperature no higher than 25 °C, because the ointment melts when exposed to high temperatures.

It is also important to protect the drug from direct sunlight, because it loses its therapeutic properties. Do not use the ointment after the expiration date. Shelf life – 3 years from the production date, which is indicated on the packaging (on the box or on the tube).

Available without a prescription.

What can replace Ibuprofen gel?

If for some reason it is impossible to use Ibuprofen gel, it can be replaced with analogues in composition or therapeutic effect. The pharmaceutical industry offers many analogues of domestic or foreign production, but still, before using similar products, you need to familiarize yourself with their instructions, scope and other information. Ibuprofen analogues have different prices and compositions, but have identical principles of action. The closest analogues include the following drugs:

• Gel Nurofen 5%.
• Dolgit ointment or gel.
• Gel Brufen.
• Ibutop.
• Fastum gel.
• Nise gel.
• Diclofenac 5%.
• Emulgel Voltaren 1%.
• Indomethacin ointment 10%.

Analogs include other topical drugs from the group of non-steroidal anti-inflammatory drugs

However, any medicine must be used with caution and all recommendations and dosages must be followed.

Nurofen gel or Ibuprofen – which is better?

Nurofen, one of the most common analogues of Ibuprofen. Both drugs contain the same amount of active substance and are widely used in practice. The difference between the drugs is the country of origin. So Nurofen is produced in the UK, and Ibuprofen is a domestic drug. There is also a difference between medicines in price, since a foreign-made drug is several times more expensive than our domestic one. By and large, the difference between the drugs is small, but still many believe that Nurofen is more effective, acts much faster, and has a minimum of contraindications. Despite the cheapness of Ibuprofen gel, some patients support the domestic manufacturer, and when comparing the two drugs, they do not see a significant difference. The price for Nurofen is about 160 rubles per package of 50 mg.

Diclofenac or Ibuprofen - what is the difference?

You can replace Ibuprofen gel with Diclofenac, which is not a structural analogue of the drug, but has the same principle of action. The drug is available in the form of a 1% gel or ointment, it is a non-hormonal analgesic, quickly relieves pain, relieves inflammation in joint diseases and muscle pain. Unlike Ibuprofen, Diclofenac ointment or gel has a wider list of contraindications and is not allowed for use by children and pregnant women. However, in terms of potency, Diclofenac is a stronger drug and has a high degree of toxicity, which does not allow its use for a long time. Diclofenac, as well as Ibuprofen, are products of a domestic pharmaceutical company. The price of Diclofenac cream or gel is 50 rubles per package of 50 mg.

Dolgit or Ibuprofen gel – what to choose?

A structural analogue of Ibuprofen gel is Dolgit gel or cream, which contains 50 mg of ibuprofen. The drug relieves pain well, relieves inflammation, pain, and is often prescribed in the complex treatment of diseases of the joints and spine, which are accompanied by pain, tissue swelling, and inflammation. The use of cream or gel allows you to improve joint mobility and increase range of motion. The drug penetrates deeply into tissues, improves blood microcirculation and metabolic processes, but has only a local effect and does not affect systemic processes. During pregnancy, the use of the drug should be discontinued. It is not recommended to use the cream for more than 7 days. Unlike Ibuprofen, Dolgit has a higher cost, which is 95-250 rubles, depending on the volume of the tube.

Nimid or Ibuprofen – which is more effective?

For the treatment of joint diseases, Nimid is often used in the form of a gel, which is not a structural analogue of Ibuprofen, since it contains another active ingredient - nimesulide. Nimid gel is a fairly popular drug with a pronounced anti-inflammatory and analgesic effect. It has a quick effect, relieves pain well, reduces morning stiffness and joint swelling. Unlike Ibuprofen, nimesulide preparations are stronger. The drug is contraindicated for children and pregnant women. A distinctive feature of Nimid gel is that the use of the drug makes it possible to enhance corticosteroid receptors, thereby increasing anti-inflammatory activity several times. The price of Nimid gel in pharmacies does not exceed 155 rubles per 30 g tube.

Compound

It is produced in the form of a colorless gel with a specific odor for external use. The composition of the drug includes ibuprofen at a dose of 50 mg per gram of gel. The medicine is produced in tubes of 20, 30, 50, 100 grams.

Auxiliary components are:

• purified water;
• propylene glycol;
• lavender oil;
• carbomer;
• dimexide.

Analog drug Advil

Available in the following forms:

• dragee;
• drops;
• capsules;
• syrup;
• suspension;
• pills.

The main substance in the product is Ibuprofen. Refers to non-steroidal anti-inflammatory drugs.

Indications:

• inflammatory and degenerative diseases of the musculoskeletal system;
• osteochondrosis;
• arthritis;
• toothache;
• headache;
• radiculitis;
• postoperative syndrome;
• adnexitis.

Contraindications:

• gastric and duodenal ulcers in the acute stage;
• pathology of the hematopoietic system;
• pregnancy;
• lactation;
• liver and kidney diseases;
• high blood pressure.

Dosage

The drug is taken after meals in a dose of 400–600 mg 3–4 times a day. The dose may vary depending on the disease and its course.

Action:

• anti-inflammatory effect;
• analgesic;
• antipyretic.

What does ibuprofen help with?

The medicine Ibuprofen is a non-narcotic analgesic that belongs to the NSAID group. Has pronounced anti-inflammatory activity. These properties allow the drug to be used for fever and pain (mild to moderate intensity), polymyalgia rheumatica, and inflammatory and degenerative diseases of the musculoskeletal system. Ibuprofen is included in the WHO list of essential medicines.

Ibuprofen: what do these pills help with?

Tablets are prescribed for:

• inflammatory diseases of the spine and joints (ankylosing spondylitis, gouty and rheumatoid arthritis, osteoarthritis, etc.);
• moderate pain of various etiologies (the medicine helps with pain during menstruation, toothache, headache, migraine attack, myalgia, neuralgia, post-traumatic and postoperative pain, etc.);
• fever due to infectious or “cold” diseases.

Ibuprofen - what else are these tablets prescribed for?

It should be remembered that tablets (like other dosage forms) are intended for symptomatic therapy, reducing pain intensity and relieving inflammation; the medicine has no effect on the progression of pathology.

Indications for use of gel and ointment

• psoriatic, gouty and rheumatoid arthritis;
• humeroscapular periarthritis;
• osteoarthritis;
• radicular syndrome with osteochondrosis;
• Bekhterev's disease;
• bursitis;
• sciatica;
• lumbago;
• radiculitis;
• myalgia;
• tendovaginitis;
• tendinitis;
• worsened gout;
• injuries in which the integrity of soft tissues is not compromised (rupture/sprain of ligaments, dislocation, bruise, post-traumatic swelling, etc.).

Use of suppositories and syrup

Ibuprofen syrup and suppositories are dosage forms that were developed specifically for use in pediatric practice. They are prescribed to children for:

• reducing temperature during acute respiratory viral infections, childhood infections, influenza and other infectious and inflammatory diseases accompanied by hyperthermia;
• decrease in temperature during post-vaccination reactions;
• reducing the intensity of mild/moderate pain (the product can be used for toothache and headache, ear or throat pain, ligament damage, neuralgia, etc.).

Suppositories are intended for children 3-24 months, Ibuprofen syrup is used to treat children from 3 months to 12 years.

Indications and contraindications

These include:

• rheumatoid arthritis;
• arthrosis;
• Bekhterev's disease;
• neuritis;
• lumbar osteochondrosis in the acute stage;
• adnexitis in combination with other agents;
• proctitis in acute form;
• osteochondrosis;
• ENT pathologies together with other groups of drugs;
• migraine attack;
• tooth pain;
• gout in the acute period;
• sciatica.

Contraindications:

• various dermatoses;
• eczema;
• preschool age;
• bearing a fetus in the third trimester;
• lactation;
• injured surface;
• Be careful not to get the gel on the mucous membrane;
• stomach diseases in the acute stage;
• pathologies of the hematopoietic organs;
• optic nerve diseases;
• liver and kidney diseases with severe course.

Ibuprofen - composition of tablets

Ibuprofen is a non-steroidal anti-inflammatory tablet that has a triple effect on the body. When considering the drug Ibuprofen, it is impossible to clearly answer what these tablets are for. The medicine has several effects at once. It not only localizes the source of inflammation, but also perfectly relieves pain and normalizes body temperature. This effect is achieved thanks to its unique composition. Active substances can quickly inhibit inflammatory factors: they reduce the synthesis of cyclooxygenases and disrupt the metabolism of arachidonic acid.

As a result, there is a decrease in the synthesis of prostaglandins in healthy tissues and the site of inflammation, which suppresses the exudative phase of inflammation - pain sensitivity decreases. The antipyretic effect is due to a decrease in the excitability of thermoregulation centers located in the diencephalon. If we consider in detail the drug Ibuprofen itself and the composition of the tablet, it is necessary, in addition to the active substance, to highlight additional components:

• potato starch;
• magnesium stearate;
• povidone;
• calcium stearate.

Pharmacokinetics

When 5% Ibuprofen gel is applied externally, it is absorbed slightly and does not have a pronounced effect on the body.
It slowly penetrates into the joint cavity, but remains for a long period in the synovial tissue, creating a high concentration in it, greater than in plasma. Here the drug is metabolized and forms three main metabolites. The drug is excreted through the kidneys. The main substance in the gel quickly penetrates biological membranes, skin and mucous membranes. The drug belongs to non-steroidal anti-inflammatory drugs.

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Its mechanism of action is associated with the inhibition of COX. Cyclooxygenases are a group of enzymes that synthesize prostaglandins, thromboxanes and prostacyclins. Inhibition of COX reduces the intensity of inflammation and pain.

When applied externally, the drug is practically not absorbed; no more than 5% of the active substance enters the blood, which is excreted in the urine. Complete absorption of ibuprofen occurs when using rectal suppositories, injections or oral tablets.

When used locally, the components penetrate through the pores of the skin to the inflamed joint and are retained in small quantities in the synovial (interarticular) fluid.

How does the medicine work?

Ibuprofen is the name of a substance found in many dosage forms with the same name. This means that tablets, ointments, and syrups called “Ibuprofen” have similar properties, despite differences in the method of application.

Ibuprofen tablets have long been successfully used to eliminate the symptoms of many diseases that cause pain and discomfort. Now a new form has become available - Ibuprofen gel. What the medicine helps with is well known to athletes who use the medicine to relieve pain from sprains or injuries.

The main active ingredient in the drug has the ability to suppress the synthesis of enzymes that increase the sensation of pain. And the additional component of the drug, dimethyl sulfoxide, penetrates into tissues and eliminates inflammatory processes.

When should you use the gel?

Like other forms of the drug, Ibuprofen gel has an anti-inflammatory effect, but when used externally, when it is necessary to reduce or eliminate pain in certain areas of the body.

Most often, the need to use Ibuprofen gel occurs in diseases of the musculoskeletal system or traumatic injuries. The mentioned pathologies are based on inflammatory processes of various etiologies. Eliminating inflammation is one of the main tasks performed by Ibuprofen.

In addition, indications for the use of Ibuprofen gel are muscle and cartilage pain, sprains and hematomas, swelling and inflammation, pain syndromes of any localization. In some cases, the drug is used to reduce the stiffness of movement characteristic of certain spinal diseases.

The gel helps relieve pain in bone tissue lesions - penetrating deeply into the synovial tissue, the drug provides a local therapeutic effect and an anti-inflammatory effect, and the pain subsides.

Types of diseases indicated for use of the drug

As an external remedy, Ibuprofen gel helps with most manifestations of inflammatory processes:

• development of osteochondrosis;
• arthrosis;
• arthritis;
• gout;
• neuralgia;
• radiculitis;
• bursitis;
• Bekhterev's disease.

Due to its high efficiency, Ibuprofen in gel form is prescribed for providing first aid to injured people, to restore the functioning of the muscular-ligamentous system, as well as to stimulate the rehabilitation processes of postoperative patients.

Price in pharmacies in Moscow, St. Petersburg, regions

The ointment is popular not only due to its many therapeutic functions, but also due to its price - it is one of the most affordable drugs. The cost depends on packaging, manufacturer, and place of sale. Prices in the Russian Federation are approximately the same and in pharmacies you can buy Ibuprofen ointment in a 25 g tube at a price of 30 to 50 rubles.

Ibuprofen ointment is a drug that is used to reduce pain. Before use, be sure to read the instructions for use for indications, contraindications and dosage, so as not to provoke the occurrence of adverse reactions.

Article design: Oleg Lozinsky

Pharmacotherapeutic group

Nonsteroidal anti-inflammatory drug (NSAID), a derivative of phenylpropionic acid.

Analogue Nurofen gel

The drug is a non-steroidal drug that has an anti-inflammatory and analgesic effect. Available as a clear 5% gel with the scent of isopropyl alcohol. The main component is ibuprofen in a dose of 50 mg. Here we wrote about painkillers for back pain.

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Indications:

• pain in the spine;
• myalgia;
• arthritis, arthrosis;
• neuralgia;
• soft tissue injuries.

Read about the symptoms of neuralgia in adults here.

Contraindications:

• if the patient has a history of allergies to aspirin and other drugs that are non-steroidal drugs;
• violation of the integrity of the skin;
• children under 14 years of age;
• pregnancy in the 3rd trimester;
• bronchial asthma;
• individual intolerance to the components in the gel.

Application

Prescribed for children over 14 years of age and adults. Squeeze about 10 cm of gel onto the skin and gently rub it into the skin. The next dose should be applied only after 4 hours.

The maximum permissible dose per day is 3 or 4 times. The course of treatment is two or three weeks. The cost of the drug in the Russian Federation is about 100 rubles per 20 grams.

Storage conditions and shelf life

The shelf life of Ibuprofen is 3 years . It is forbidden to take expired medication, as this can lead to serious health problems.

Storage should take place in a place inaccessible to children. The medicine requires a dry place with a maximum temperature of +25 degrees .

You can find instructions for using Nurofen syrup for children, another effective antipyretic drug for children, in another informative review.

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An analogue of Ibuprofen is Ibufen children's syrup. Find out how to take it from this article:.