Physiotens - instructions for use, analogs, reviews and release forms tablets 0.2 mg, 0.3 mg and 0.4 mg medications for the treatment of hypertension and blood pressure reduction in adults, children and pregnancy

Composition and release form

Film-coated tablets	1 table
moxonidine	0.2 mg
excipients: lactose monohydrate - 95.8 mg; povidone - 0.7 mg; crospovidone - 3 mg; magnesium stearate - 0.3 mg; hypromellose - 1.3 mg; ethylcellulose - 4 mg; macrogol 6000 - 0.25 mg; talc - 0.9975 mg; iron oxide red (E172) - 0.0025 mg; titanium dioxide (E171) - 1.25 mg

14 pcs in blister; There are 1, 2 or 7 blisters in a box.

Film-coated tablets	1 table
moxonidine	0.3 mg
excipients: lactose monohydrate - 95.7 mg; povidone - 0.7 mg; crospovidone - 3 mg; magnesium stearate - 0.3 mg; hypromellose - 1.3 mg; ethylcellulose - 4 mg; macrogol 6000 - 0.25 mg; talc - 0.975 mg; iron oxide red (E172) - 0.025 mg; titanium dioxide (E171) - 1.25 mg

14 pcs in blister; There are 1, 2 or 7 blisters in a box.

Film-coated tablets	1 table
moxonidine	0.4 mg
excipients: lactose monohydrate - 95.6 mg; povidone - 0.7 mg; crospovidone - 3 mg; magnesium stearate - 0.3 mg; hypromellose - 1.3 mg; ethylcellulose - 4 mg; macrogol 6000 - 0.25 mg; talc - 0.875 mg; iron oxide red (E172) - 0.125 mg; titanium dioxide (E171) - 1.25 mg

14 pcs in blister; There are 1, 2 or 7 blisters in a box.

pharmachologic effect

The result is a decrease in peripheral symptomatic activity and blood pressure. Numerous studies (placebo-controlled, randomized, double-blind) prove the effectiveness of the drug "Physiotens".

Physiotens is a centrally acting antihypertensive drug.

In brain stem structures, moxonidine selectively stimulates receptors that are involved in the reflex and tonic regulation of the sympathetic nervous system, which leads to a decrease in peripheral sympathetic activity and blood pressure.

Moxonidine reduces systemic vascular resistance and blood pressure. Physiotens helps to increase the insulin sensitivity index.

Adverse reactions

When using the drug Physiotens, various side effects may occur. The mechanism of their manifestation is closely related to the particular characteristics of the body of a particular patient. Among the list of side effects are:

noise in ears;
a sharp decrease in blood pressure;
development of hypotension;
manifestation of pain in the temple area;
dizziness;
increased drowsiness;
feeling of dryness in the mouth;
insomnia;
decrease in heart rate;
disorders of the gastrointestinal tract;
allergic rashes on the skin.

Side effects that appear in the first 2-3 days of use are a natural reaction of the body. If such a manifestation does not lead to a significant deterioration in the patient’s well-being, dose adjustment and discontinuation of the drug is not required. If the described symptoms are intense, the drug Physiotens should be replaced with an analogue with another active ingredient. The prescription of a drug with another active ingredient should be carried out by a specialist.

Mechanism of action of the drug

The active ingredient of the pharmaceutical drug is moxonidine. This chemical compound is an irritant of specific imidazole receptors, which are most abundant in the rostral medulla oblongata. The effect of moxonidine on these sensory endings leads to the occurrence of inhibition processes in the sympathetic nervous system, which, in turn, leads to a drop in blood pressure. As a result, the tone of the arterial vascular wall is weakened and the heart rate decreases.

Although pharmacists classify this drug as a centrally acting drug, it does not have a significant sedative effect and is not addictive.

Contraindications Physiotensa

Physiotens in any dosage is contraindicated if there are:

individual intolerance to any component;
allergic reactions to the components of the drug;
hereditary lactose intolerance, lactase deficiency, galactose malabsorption syndrome;
pregnancy and lactation;
childhood;
severe bradycardia (heart rate less than 0 beats per minute);
sick sinus syndrome;
atrioventricular block II and III degrees;
heart failure (acute and chronic).

The drug should be used with caution if the patient:

Severe renal failure and end-stage renal failure.
Liver failure.
Severe atherosclerosis of the coronary arteries.
Unstable angina.

Contraindications to the use of the drug

There are also some contraindications to the use of the presented medication. It is worth noting that immediately before starting treatment, you should carefully study them, and in addition, consult with your doctor and, if in doubt, select analogues. Patients may need analogues in the following cases:

In the presence of sick sinus syndrome.
Against the background of bradycardia, when the heart rate does not exceed fifty beats per minute.
In case of acute heart failure.
Against the background of galactose intolerance by the patient. And also with lactase deficiency or malabsorption of galactose and glucose, which is genetically determined.
For some physiological conditions of the patient, as well as for age factors.
If there is an individual intolerance to the main or excipients of the presented medicinal product.

It should be emphasized that analogues have similar side effects and contraindications. Therefore, before abandoning Physiotens and starting to select analogues, it makes sense to adjust the dosage and minimize the factors that provoke side effects.

Analogues of Physiotens

Structural analogues of the active substance:

Attention: the use of analogues must be agreed with the attending physician. Average price of PHYSIOTENZ, tablets in pharmacies (Moscow) 286 rubles

The average price of PHYSIOTENZ, tablets in pharmacies (Moscow) is 286 rubles.

Physiotens is a medicine for hypertension, the active ingredient of which is moxonidine. These tablets belong to the group of centrally acting drugs. Many patients with hypertension believe that physiotens is a vasodilator, but this is not entirely accurate. In our article you will learn everything about how to take physiotens for blood pressure. This medicine has inexpensive analogues, the active ingredient of which is also moxonidine. They are listed below in a convenient table.

Pressure physiotens - everything you need to know:

Official instructions for use;
How to take Physiotens (moxonidine): dosages;
Indications, contraindications, side effects;
Inexpensive substitutes, analogues, including Russian ones;
Reviews from patients who are treated with these tablets;
How to stop a hypertensive crisis with physiotens.

Physiotens may help if you have hypertension combined with overweight (obesity) or type 2 diabetes. But if you are of a thin build, then it is better to switch to other tablets, as recommended by your doctor. Read more below. In any case, get examined to find the causes of hypertension. You need to be treated thoroughly, and not just hastily swallow pills just to lower your blood pressure and muffle other unpleasant symptoms.

During pregnancy and lactation

A sufficient number of studies have not been conducted that would give a clear answer to the question of the safety of Physiotens for a pregnant woman and a pregnant fetus or for a nursing child. Studies carried out on animals have shown the embryotoxic effects of the drug. The official instructions provide the following recommendations:

Do not use this drug to lower blood pressure in pregnant women without consulting your doctor.
During lactation, do not use Physiotens, since it is excreted in breast milk, or stop feeding for the duration of treatment (and another couple of days for complete elimination).

Indications for use

Indications for use of the drug Physiotens are arterial hypertension (hypertension). These tablets are especially suitable for patients whose hypertension is caused by metabolic syndrome (obesity) or whose condition is aggravated by type 2 diabetes. In the vast majority of cases, physiotens is prescribed along with other blood pressure pills to carry out combined treatment. This method gives the maximum chance that it will be possible to achieve the target blood pressure values of 140/90 mm Hg. Art. and below. And if you take moxonidine without other drugs for hypertension, the result is good in less than half of the patients.

Benefits of these tablets for treating hypertension

Physiotens (moxonidine) is a third-generation imidazoline receptor agonist, a centrally acting medicine for hypertension. It is the most popular drug of this group, both in Russian-speaking countries and abroad. To normalize blood pressure, tens of thousands of patients take these pills, and people write reviews that they are more or less satisfied with the results.

Benefits of physiotens for the treatment of hypertension:

Can be taken on an empty stomach or after meals. The effectiveness and speed of action of the medicine does not depend on food intake. The effect of lowering blood pressure continues for a whole day after taking the tablet. And this despite the fact that the active substance, moxonidine, is quickly eliminated from the body. Physiotens goes well with other blood pressure medications that belong to all major classes. It can also be taken together with cardiac glycosides and diabetes pills. This medicine not only lowers blood pressure, but also improves tissue sensitivity to insulin, i.e., weakens insulin resistance. Moxonidine is the only drug for hypertension for which this property has been officially proven

It is important for patients with hypertension aggravated by type 2 diabetes or metabolic syndrome.

Obese patients with hypertension while taking physiotensa lose weight slightly, by 1-4 kg within 6 months. As they say, it’s a small thing, but it’s nice. The results of blood tests for total, “good” and “bad” cholesterol, triglycerides and fasting glucose also improve.

Medicine Physiotens

High blood pressure occurs in many people, especially those at risk due to age and genetic predisposition. Physiotens tablets are recommended for patients suffering from second and third degree hypertension, especially if the disease is aggravated by obesity, erectile dysfunction in men, anorgasmia or cycle failure in women. Thanks to the administration of the drug, a decrease in insulin resistance is observed. The medicine not only reduces blood pressure, but also improves cerebral circulation.

Composition and release form

The main active ingredient is moxonidine. Additional components are lactose, cellulose ethyl ether, magnesium stearate, povidone, iron oxide, titanium dioxide, macrogol - these components improve the absorption of the base treatment compound and facilitate the excretion of metabolites. Physiotens blood pressure tablets are available in various dosages, depending on the recommended dose of moxonidine.

Pharmacodynamics and pharmacokinetics

The drug is part of the group of central antagonists of imidazoline receptors, which are responsible for the tonic, reflex regulation of the sympathetic nervous system, including hypertension due to the malfunction of these receptors. When entering the human body, the components bind to adrenergic receptors and reduce the activity of the secretion of the hormone adrenaline. As a result, the drug has the following positive effects:

Corrects arterial hypertension, having a pronounced hypotensive effect. Physiotens is considered the first choice drug for hypertensive crisis.
Normalizes the sympathetic activity of the nervous system.
During long-term use, it strengthens myocardial vessels, kidneys, and intestinal walls.
Helps lower blood sugar and improve overall health - relieves dizziness, angina, acts as a mild diuretic.
Does not have a sedative effect, does not cause drowsiness, or impaired concentration.

Absorption is up to 90%. Metabolites are excreted in the urine, 80% unchanged. The full withdrawal cycle is 24 hours. About one percent of metabolites are excreted in the feces. Residual substances do not accumulate in the body and do not produce long-term effects on organ systems. In elderly patients, minor variations may occur due to metabolic changes, but the variations are not considered clinically significant.

Indications for use

For a single episode of hypertension, doctors do not prescribe Physiotens - the instructions for its use imply that it should be taken only in case of pronounced changes in the body against the background of a chronic increase in pressure. The dose is determined by the attending physician; self-prescription of this medicine is unacceptable. The main indications are arterial hypertension of the second and third stages, obesity and diabetes mellitus as additional diseases. The drug is especially relevant if beta-blockers are ineffective.

Instructions for use

Physiotens comes with instructions for use. It is worth reading it carefully before you start taking the pills. The annotation contains the dosage, regimen, and duration of the course.

These data are approximate. The doctor may change the recommended dose and duration of therapy.

The treatment regimen is developed taking into account the patient’s well-being, weight and age, stage and form of hypertension, and the presence of concomitant pathologies.

Tablet dosage

The drug is started with small doses. This is done in order to check the body's reaction to the new medication. The optimal starting dosage is 0.2 mg. Further, according to indications, the daily amount of moxonidine is gradually increased. You are allowed to drink a maximum of 0.6 mg of the drug per day.

A single dose should not be more than 0.4 mg. If a person has renal failure and is on hemodialysis, then Physiotens in low concentration is indicated. The optimal dose in this case is 0.2 mg. If well tolerated, the dosage can be increased to 0.4 mg per day.

Mode of application

To enhance the effect of the medication, you need to put the tablet under your tongue.
Use the medicine 1-2 times a day, depending on the dosage. If the doctor prescribed 0.2-0.4 mg of moxonidine per day to the patient, then this dose is drunk at a time.

If the doctor recommended taking 0.6 mg, then take the tablets twice a day: morning and evening. It is recommended to use the drug at approximately the same time, without skipping. The medicine is effective for 24 hours. If you take the tablets every day, this will help maintain the optimal concentration of moxonidine in the blood, excluding sudden jumps.

Food intake does not affect the pharmacokinetics of Physiotens. Therefore, it is allowed to drink the product regardless of the time of eating. The duration of the course is determined by the doctor individually, based on the results of the examination and the patient’s well-being.

When using Physiotens, you need to take into account its interaction with other medications. For example, the drug does not combine well with beta-blockers.

Therefore, a few days before starting Physiotens, these medications are discontinued.

During therapy, it is important to constantly monitor blood pressure using a tonometer and pulse rate. It is also recommended to periodically do an electrocardiogram

Stop taking Physiotenza gradually.

Cautions

If the patient suffers from moderate or even severe renal failure or is on hemodialysis, then the initial dose should not exceed 200 mcg/day. Only in case of good tolerance and urgent need is it possible to increase the daily dose to 400 mcg.

It is not advisable to use the substance for persons who have been diagnosed with severe coronary artery disease, unstable angina, or heart failure.

An overdose of Moxarel is accompanied by the following symptoms:

powerful sedative effect;
headaches, severe drowsiness;
dizziness;
vomiting and asthenia;
sometimes the muscles of the back or neck hurt;
disturbances of consciousness (insomnia, nervousness) and respiratory depression;
in rare cases, ringing in the ears and allergic rashes are observed.

If these symptoms are detected, the patient should notify his or her physician.

Interaction of Moxonidine and Moxarel with other drugs

When taking a domestic drug, it is important to remember that it can enhance the effects of other drugs on the body, for example, sleeping pills, sedatives, tranquilizers or tricyclic antidepressants. Moxonidine may moderately improve impaired cognitive function in people taking Lorazepam

If you use Moxonidine together with drugs based on benzodiazepine derivatives, you can get a strong sedative effect.

The use of the drug in conjunction with beta-blockers in a patient will cause increased bradycardia. It has not been clinically confirmed that abrupt discontinuation of the drug Moxarel leads to an increase in blood pressure. But doctors recommend stopping use gradually, gradually reducing the dose over 14 days. It is advisable to carry out treatment with Moxarel with regular monitoring of heart rate and blood pressure; in addition, ECG checks are necessary.

Pregnancy and lactation

Since it has not been clinically established what specific effect it has on pregnant women, drugs from this group should be used carefully, with a careful assessment of the possible risks

It is important to remember that Moxonidine is easily passed on to the baby through breast milk. Doctors strongly recommend that you stop breastfeeding during treatment.

If this is not possible, be sure to stop taking the medication.

Manufacturers prohibit the use of the medicine by minors. This is due to the lack of clinical studies. In addition, it is not recommended to use the drug for elderly people (over 75 years old).

To maximize the effectiveness of treatment, it is important to conduct a comprehensive diagnosis and find out the root cause. Only after passing the entire range of examinations and consulting with a specialist should you begin treatment

Moxarel and similar drugs are not recommended for people with hypersensitivity to galactose and moxonidine.

Effect of physiotens

There are three types of so-called imidazoline receptors in the human brain:

I1 receptors are responsible for reducing the hyperactivity of the sympathetic nervous system and controlling blood pressure;
I2 receptors – regulate the release of the hormones norepinephrine and adrenaline;
I3 receptors control the production of insulin by beta cells of the pancreas.

Moxonidine, the active ingredient in physiotens tablets, affects all the receptors listed above. It has a complex effect on blood pressure and metabolism. Thanks to this, the patient’s blood pressure not only decreases, but also the results of blood tests for cholesterol, triglycerides and glucose improve

This is important for patients who have hypertension combined with overweight (obesity) or type 2 diabetes

An agonist is a chemical substance that, when interacting with a receptor, changes its state, leading to a biological response. Conventional agonists increase the receptor response, inverse agonists, on the contrary, reduce it, and antagonists block the action of the agonists. Moxonidine is an imidazoline receptor agonist. The drug physiotens has a positive effect on carbohydrate metabolism, including due to the fact that it increases the expression of the β-subunits of the insulin receptor in tissues. This leads to improved insulin signaling pathways in skeletal muscle and liver.

How does physiotens lower blood pressure?

helps remove more sodium (salt) and water from the body;
reduces renin activity by 20-40%, the concentration of norepinephrine and adrenaline in the blood - hormones that cause vasospasm and increase blood pressure;
increases the sensitivity of cells to insulin, due to which the body gets rid of excess fluid, blood vessels relax;
Perhaps there are some other mechanisms.

Blood pressure pills: questions and answers

How to normalize blood pressure, blood sugar and cholesterol at the same time
The blood pressure pills prescribed by the doctor used to help well, but now they have become less effective. Why?
What to do if even the strongest pills do not reduce blood pressure
What to do if hypertension medications lower your blood pressure too much
High blood pressure, hypertensive crisis - features of treatment in young, middle and old age

Drug treatment of hypertension

To localize the manifestations of arterial hypertension, the patient has to take medications on a regular basis, and not just during exacerbations. And this despite the fact that every medicine has side effects that, although in small quantities, still affect the body. One of the best drugs prescribed for hypertension in the post-Soviet space is the German drug Physiotens. It is based on a substance such as moxonidine (promotes the normalization of nervous regulation, dilates blood vessels). This drug is suitable for those who:

suffers from stage 2-3 hypertension;
has high blood pressure caused by excess weight, type 2 diabetes;
lives with a reduced metabolic rate.

One of the main advantages that Physiotens has is that it does not require strict adherence to the dosage schedule. That is, the patient can take the medicine whenever he wants, without reference to food intake. Most often, this drug is used in combination with other medications (does not affect the effectiveness of third-party medications).

Effect on internal organs

Physiotens stimulates the work of the heart, and due to this, special receptors are produced in the brain stem that are responsible for the reflex and tonic regulation of the nervous system. In addition, the substances produced reduce sympathetic activity, which affects the functioning of the heart and normalizes blood pressure. Physiotens is characterized by the absence of interaction with adrenergic receptors. This feature allows patients taking this medicine to forget about the sedative effect and dry mouth.

In patients after taking this medication, metabolism is normalized (quantitative indicators of triglycerides, cholesterol, blood glucose), and a decrease in vascular resistance is observed. The effectiveness of the drug has been repeatedly confirmed by clinical studies (several hundred of them were conducted). Even in insulin-dependent people and those who suffer from obesity, taking the drug lowered blood pressure; In addition, it is quickly eliminated from the body and is compatible with other drugs. The medicine is applicable both continuously as part of complex therapy, and once (on an empty stomach, before and after meals).

Side effects

Since Physiotens is primarily a centrally acting drug, it is not recommended for people who are underweight or have a fast metabolism. In addition, the drug is contraindicated in people who are hypersensitive to moxonidine and galactose.

In such patients, the medicine can cause fever, stomach upset, and severe itching. Physiotens is not recommended for women during lactation (there is a possibility that the active medicinal substances from the drug can enter the baby’s body through milk).

The components of Physiotens affect the kidneys and heart, so it should be taken only after the recommendation of an experienced doctor and under his strict supervision. Despite the safety of the drug, in some patients it may cause:

state of drowsiness (dangerous for drivers);
nausea and headaches;
sleep disturbance;
disruption of the digestive system (diarrhea, constipation).

Some patients taking the drug experienced fainting and heart problems.

https://youtube.com/watch?v=Pm75Hd0uIp8

Instructions for use Physiotens, dosages

Physiotens tablets are intended for oral administration, regardless of food. Take without chewing/dividing - wash down with clean water.

It is important to start with the lowest dosage of the drug and adjust it as necessary. The recommended starting dose is 0.2 mg per day

The maximum daily dose is 0.6 mg in 2 doses.

The maximum single dose is 0.4 mg.

Individual adjustment of the daily dose is necessary depending on the patient’s tolerance to the therapy.

For renal failure (creatinine clearance 30–60 ml/min) and in patients on hemodialysis, a single dose is Physiotens 0.2 mg, maximum daily dose is Physiotens 0.4 mg.

Today there is no evidence of the development of dependence on the drug or confirmation that stopping taking Physiotens leads to an increase in blood pressure. However, cardiologists do not recommend abruptly stopping the medication; it is better to gradually reduce the dosage over 10-14 days.

The combined use of Physiotens with other means to reduce blood pressure leads to an increase in their effect - the pressure may drop too much!

Side effects and contraindications

Main side effects of Physiotens:

headache, dizziness, drowsiness;
dry mouth;
bradycardia and weakness;
asthenia;
nervousness;
tinnitus;
backache;
neck pain;
skin allergies, urticaria.

The most common side effects observed in patients taking moxonidine are dry mouth, headache, dizziness, asthenia and drowsiness. After the first 14 days of taking the medication, the severity of symptoms decreases.

Physiotens increases the depressant effect on the central nervous system of anxiolytics, barbiturates and ethanol. The combined effect and addition of alpha-blockers to treatment is determined by their dose. Mutual enhancement of the effect when combined with other blood pressure-lowering drugs. Beta-blockers increase bradycardia and the severity of negative ino- and dromotropic effects.

If it is necessary to cancel concomitantly taken beta-blockers and Physiotens, beta-blockers are canceled first.

Contraindications

The instructions for use of Physiotens describe the following contraindications:

heart failure;
bradycardia;
children (under 18 years old);
individual sensitivity (allergy) to the components of the drug;
liver and kidney diseases;
sick sinus syndrome.

There is no confirmed data on the negative impact on pregnancy, but Physiotens should be prescribed during pregnancy with caution, only after a careful assessment by the doctor of the risks and benefits, when the benefit to the mother outweighs the potential risk to the fetus. Moxonidine passes into breast milk

During lactation it is necessary to discontinue the drug or stop breastfeeding

Moxonidine passes into breast milk. During lactation, it is necessary to discontinue the drug or stop breastfeeding.

Overdose

An overdose of Physiotens can cause drowsiness and headaches, as well as cause a severe decrease in blood pressure. Treatment is symptomatic, the patient is advised to administer fluids and dopamine.

Use during pregnancy and lactation

A biological study did not establish a negative effect on the body of adult animals and their young.
There is no clinical data on the mechanism of action and the effect on the human fetus. Therefore, experts are cautious about taking the medicine during pregnancy. Physiotens or Moxonidine are prescribed to pregnant women with extreme caution, after assessing the mother’s condition and possible risks.

The medicine is prescribed only when the benefit to the mother's body outweighs the possible risk of negative effects on the fetus.

During lactation it is not recommended to use the medicine, since the active substance passes into breast milk. When taking the drug, you must stop breastfeeding.

Drug interactions

Experts say that when Physiotens is combined with other antihypertensive drugs, an additive effect is observed: they reinforce each other, which helps to lower blood pressure faster, but also increases the severity and number of adverse reactions. The combination of Physiotens with thiazide diuretics and calcium channel blockers is considered the safest. This drug has a unilateral effect on:

tricyclic antidepressants;
ethanol-based preparations;
sedatives (calming agents);
sleeping pills;
benzodiazepine derivatives (increasing only sedative quality).

At the same time, the mentioned tricyclic antidepressants weaken the effect of all centrally acting antihypertensive drugs, so their combination in a long-term therapeutic course is not recommended. A few more points of drug interaction:

Concomitant use of beta-blockers with moxonidine leads to increased bradycardia.
No pharmacokinetic interaction has been recorded with Hydrochlorothiazide (their full compatibility is assumed), Digoxin, Glyburide.
Simultaneous use of Physiotens with Lorazepam can improve cognitive abilities weakened by the latter.
If you have to stop taking the drug and alpha-blockers at the same time, first stop taking the latter and wait a few days.
In order to enhance the antihypertensive effect, you can drink magnesium in combination with vitamin B6 along with Physiotens.

What to replace it with?

There are quite a lot of drugs with a similar composition and mechanism of action on the market for drugs to lower blood pressure. The most common analogues of Physiotens tablets are “Tsint”, “Moxonitex”, “Moxonidine”, “Moxogamma”. If the composition of the medication is not suitable for a person, then the doctor will be able to select an antihypertensive drug based on the mechanism of action, which has a different composition but the same effect.

Drug interactions

The combination of medications is not always given due importance. However, when taking two or more drugs, a weakening or strengthening of mutual effects may be observed. In the first case, the medicine will not give the expected result; in the second situation, there is a risk of overdose and even poisoning.

Thus, when using antihypertensive drugs (thiazide diuretics, calcium slow channel blockers) together with the drug “Physiotens” (reviews warn about this), an additive hypotensive effect may develop. The simultaneous use of tricyclic antidepressants reduces the effectiveness of central antipertensive drugs, so they should not be used together with the drug Physiotens.

In addition, the drug can improve cognitive impairment in patients taking the drug Lorazepam. Use together with benzodiazepines may cause increased sedation. When prescribed with the drugs Digoxin, Glibenclamide, Hydrochlorothiazide, there is no pharmacokinetic interaction.

Contraindications

Any medicine has its contraindications. If you take the drug when you are prohibited, this may negatively affect your well-being and lead to the development of side effects. You need to be especially careful when using cardiovascular medications.

Physiotens has the following contraindications:

intolerance to moxonidine and other components of the medication;
atrioventricular block of the second or third degree;
bradycardia (pulse less than 50 beats per minute);
age under 18 years;
sick sinus syndrome;
heart failure of any course.

special instructions

Post-marketing surveillance has documented cases of AV block of varying severity in patients taking moxonidine. A connection between taking Physiotens and slowing AV conduction cannot be completely excluded

Therefore, caution is advised when treating patients likely to develop AV block.

If it is necessary to discontinue beta-blockers and the drug Physiotens taken simultaneously, beta-blockers should first be discontinued and only after a few days Physiotens should be discontinued.

There is currently no evidence that discontinuation of Physiotens leads to an increase in blood pressure. However, it is not recommended to stop taking Physiotens suddenly; instead, you should gradually reduce the dose of the drug over 2 weeks.

Influence on the ability to drive vehicles and control machines and mechanisms

Studies of the effect of the drug on the ability to drive a car and other mechanisms have not been conducted. There are reports of drowsiness and dizziness during treatment with moxonidine, which should be taken into account in patients engaged in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Use during pregnancy

Various drugs have a negative effect on the fetus or embryo, leading in some cases to malformations of the child. Also, the components of medications taken with mother’s milk can enter the infant’s body and act on it.

Therefore, during pregnancy and lactation it is necessary to take medications with increased caution.

The drug “Physiotens” is no exception. Its use is permissible only after consultation with a specialist, having carefully weighed the possible benefits for the mother and harm to the child. Since the active ingredient passes into breast milk, it is necessary to stop using it or stop feeding the baby while feeding the baby.

Experimental studies conducted on animals did not reveal a direct or indirect effect of the drug on pregnancy, embryonic (fetal) or postnatal development.

Instructions for use

Physiotens blood pressure tablets are intended for oral administration, and there are 2 acceptable ways to use them. If you need to get a quick effect, you should put the tablet under the tongue and slowly dissolve - the active substance will immediately penetrate into the blood, which will reduce blood pressure in a short time. It is advisable to resort to this method only in emergency cases. According to the official instructions, the tablet is swallowed without chewing. It is advisable to drink it with water (room temperature) - this will make it easier to swallow. A few additional nuances:

The pharmacokinetics of moxonidine is not affected by food intake - the maximum concentration in the blood plasma will be diagnosed after 1 hour in any situation. If you have stomach problems, doctors do not recommend taking the medicine on an empty stomach.
The initial dosage is 200 mcg, the frequency of administration is 1 time per day. The maximum amount of moxonidine per day is 600 mcg (divided into 2 doses), and at a time - 400 mcg. If necessary, these figures are adjusted according to the patient's individual perception of the medicine.
In case of renal failure, the maximum dosage per day is reduced to 400 mcg, and at a time - to 200 mcg.

If arterial hypertension is constant (pressure increases daily, but not to critical values), long-term treatment is allowed, but this issue is resolved exclusively with a doctor. The drug withdrawal regimen after such a therapeutic course is also chosen by a specialist, this happens within 2 weeks. With long-term use, be sure to monitor your pulse, blood pressure, and do a cardiogram to monitor your heart function.

Hypertension in women after menopause

An international study of the effect of moxonidine on high blood pressure in women who have entered menopause showed the average effectiveness of this substance. Only 40% of the subjects reached the target values, and among women who still maintained menstrual function, the figure was significantly higher - 73%. Based on this, doctors conclude that drinking Physiotens for blood pressure after menopause is ineffective, since the indicators decrease:

systolic pressure – by 27 mmHg;
diastolic pressure – by 14 mmHg.

Relief of hypertensive crisis

Studies conducted by specialists to compare the effectiveness of Captopril (intended for emergency blood pressure reduction) and Physiotens showed that the rate of decrease in systolic (30 min.) and diastolic (60 min.) pressure is the same. The maximum reduction level is 25% of the original. For this reason, it is allowed to put Physiotens under the tongue (0.2-0.4 mg) during a hypertensive crisis instead of Captopril and its analogues. Wherein:

the effect lasts for 12 hours (versus 2 hours for Captopril);
The intensity of the headache is significantly reduced.

Pharmacodynamics and pharmacokinetics

After internal administration, the drug is 90 percent absorbed from the gastrointestinal system. The maximum concentration of the active substance in the blood plasma is observed after an hour. Food intake does not affect the pharmacokinetics of moxonidine.

The main metabolite of the active substance is dehydrogenated moxonidine, as well as guanidine derivatives. The half-life of moxonidine occurs within 2.5 hours, and after a day the element is 90% excreted by the kidneys and through the intestines.

In patients with arterial hypertension, compared with healthy people, no changes in the pharmacokinetics of moxonidine were observed. Kinetic parameters may change slightly in elderly patients, which is associated with a decrease in the intensity of metabolism of moxodinine, as well as its higher bioavailability.

Due to the lack of pharmacokinetic studies, the use of the drug in patients under adulthood is not recommended.

In case of overdose Physiotenza

The maximum dosage of Physiotens that was consumed by the patient is approximately 19 mg per day. However, it was not fatal.

If a person has exceeded the dosage recommended by the doctor, then the symptoms of malaise will be: headache, increased drowsiness, dizziness, body weakness, slow pulse, feeling of dryness in the mouth, spasmodic pain in the stomach.

In some clinical cases, with an overdose of physiotens, a person may feel tachycardia and experience a state of hyperglycemia.

In case of overdose, dopamine must be administered intravenously to the patient. If bradycardia is noted, then an injection of atropine is given.

Side effects and overdose

Physiotens is well tolerated by most patients. But some patients complain of a deterioration in their health since starting to take the drug.

Side effects are represented by the following symptoms:

swelling of the throat, face, tongue and lips, rashes on the epidermis and other manifestations of allergies;
dry mouth;
back pain;
lethargy;
dizziness;
darkening of urine;
yellowing of the skin;
headache;
weakness;
stomach upset;
sleep disturbance.

It is important to strictly follow the dose recommended by the doctor. If it is exceeded, an overdose may occur. This condition is quite dangerous.

Overdose is characterized by the following symptoms:

abdominal pain;
hypotension;
nausea;
vomit;
drowsiness;
bradycardia;
dry mouth.

If signs of adverse reactions or overdose occur, you must immediately stop taking the medication and seek medical help.

Analogs

List of the best analogues of the drug that help even with high blood pressure:

"Moxonidine LF". Belarusian analogue, the price of which is 400-600 rubles. Helps against hypertension, has an original composition.
Moxonitex. German analogue, price about 200-300 rubles. Does not affect heart rate, normalizes myocardial nutrition.
"Tensotran". Analogue, Iceland/Israel. Price 200-600 rubles.
"Moxarel". Russian analogue, cost about 300 rubles.
"Tsint." Spanish equivalent.

Cheap analogues

A good replacement for Physiotens can also be found among cheap analogues:

"Moxonidine." The price is about 150 rubles. Made in the Russian Federation;
"Ruanatin Health." The price is about 50 rubles. Made in Ukraine;
"Enalapril HL". The price is about 60 rubles. Made in Ukraine.

Drug analogues and manufacturing countries

Physiotens may not be suitable in terms of tolerability or may not be available in the pharmacy. For chronic hypertensive patients who need to take this drug daily, treatment is sometimes prohibitively expensive. In these cases, it is necessary to select an analogue.

Physiotens can be replaced with the following antihypertensive drugs:

Tenzotran (Iceland, ACTAVIS GROUP hf);
Kapoten (USA, pharmaceutical company BRISTOL-MYERS SQUIBB Company);
Onsart (Türkiye, ABDI IBRAHIM GLOBAL PHARM LLP);
Lozap (Czech Republic, pharmaceutical organization Zentiva a.s.);
Physiotech (Germany, Rottendorf company);
Felotenz (Russia, Canonpharma Production CJSC);
Physionorm (Germany, pharmaceutical company Solvay Pharmaceuticals GmbH).

Domestic analogues are cheaper. Foreign substitutes are considered to be of higher quality and, according to pharmaceutical manufacturers, are better tolerated. A doctor should select an analogue.

Physiotens is a German drug produced by the pharmaceutical company Abbott Laboratories.

Metabolism, excretion from the body

About 90% of the dose of the drug taken is absorbed, and food intake does not affect the absorption of moxonidine. The maximum concentration of the active substance in the blood plasma is 60 minutes after taking the tablet. Moxonidine is quickly eliminated from the body within a few hours, but blood pressure remains low for a long time, for about a day. This drug is excreted mainly by the kidneys, more than 90%

This should be taken into account if you plan to prescribe physiotens to a patient with renal failure.

Use for renal failure

More than 90% of the dose taken is excreted by the kidneys. If the kidneys are not working well, excretion slows down and the maximum concentration of the drug in the blood increases. A glomerular filtration rate (creatinine clearance) of 30–60 ml/min is a moderate impairment of renal function. With it, the concentration of moxonidine in the blood increases by 2 times, and excretion slows down by 1.5 times, compared with patients with hypertension whose renal function is not impaired.

If renal failure is at an advanced stage (creatinine clearance

Physiotens is an antihypertensive drug (lowering blood pressure) of central action. The effectiveness of the drug has been proven in many clinical studies: double-blind, randomized and placebo-controlled.

The active substance – Moxonidine – is a selective agonist of imidazoline receptors involved in the tonic and reflex regulation of the human sympathetic nervous system. The effect on imidazoline receptors reduces peripheral sympathetic activity and, as a consequence, blood pressure.

The active substance Physiotens differs from other sympatholytic drugs for reducing blood pressure by its lower affinity for α2-adrenergic receptors - this reduces the likelihood of sedation and dry mouth.

Selectively interacting with imidazoline I1 receptors located in the brain stem, it normalizes sympathetic activity. As a result of the drug's action, the resistance of the vascular walls and total blood pressure systemically decrease.

Physiotens tablets 0.2 mg, photo

The active ingredient Physiotens increases the insulin sensitivity index by 21.2% (in a placebo-controlled study) in patients with increased body weight, insulin resistance and moderate hypertension.

Available only in film-coated tablets with a dosage of 0.2 - 0.4 mg. Packages of 14, 28 and 98 pieces (14 in one blister).

Domestic inexpensive analogues

It is financially difficult for hypertensive patients, especially the elderly, to constantly buy Physiotens - domestically produced analogues are much cheaper, and some are even safer.

Usually, pharmacists and pharmacists select a drug from pharmacies based on the active ingredient - for Physiotens it is Moxonidine. However, you should not rely entirely on the pharmacy worker. It is better to listen to your doctor, especially since analogues may have completely different purification from excipients during production or be supplemented with specific components that are contraindicated for the patient.

The most popular Russian analogue of the European Physiotens is Moxarel. It is also a selective imidazoline receptor agonist. Its cost is lower than the German drug, but it has a similar composition. The second popular medicine is an analogue of Physiotenza, the drug Moxonidine Canon, which received the same active ingredient (moxonidine) in a dosage of 0.2-0.4 mg. This selective imidazoline receptor agonist regulates the sympathetic nervous system tonically and reflexively.

Features of hypertension

Many people are susceptible to heart and vascular diseases. However, in women these deviations develop later than in men. But their course is much more complicated and is characterized by increased blood pressure and more pronounced painful symptoms. Hypertension often develops together with other pathologies: obesity, diabetes mellitus, abnormalities in the liver and kidneys, and failure of lipid metabolism.

Along with an increase in body weight, the functioning of the SNS is disrupted, which is the main cause of high blood pressure and the formation of hypertension. Hormones secreted by the symptomatic nervous system contribute to the narrowing of the lumen of blood vessels, as a result of which the heart has to push blood with effort, under high pressure, to deliver oxygen to tissues and organs, thus developing hypertension, which has to be treated with medication. One of the medications that can curb high blood pressure is Physiotens.

Physiotens medicine for blood pressure

“Physiotens” is a special selective antagonist of imidazoline receptors, which are responsible for reflex as well as tonic control of the functioning of the sympathetic nervous system, localized in the medulla oblongata.

This drug helps to quickly and effectively lower blood pressure.

It should be noted that long-term use of this drug significantly weakens left ventricular myocardial hypertrophy and reduces peripheral vascular resistance, relieves the patient from signs of myocardial fibrosis and manifestations of microarteriopathy.

Physiotens significantly reduces vascular resistance in the lungs.

The action of the drug, in particular, is aimed at intensive restoration of capillary blood supply to the myocardium.

In addition, the medication has many other properties that have a beneficial effect on the general condition of a person and help improve the functioning of the cardiovascular system.

The effect of the tablets in most cases lasts about twelve hours , because its active substance is removed quite slowly from the central nervous system.

The drug "Physiotens" is considered a very effective remedy that can be used to treat arterial hypertension.

It should be taken only if it was prescribed by a doctor after examining the patient.

For adults, the starting dose of Physiotensa is usually 0.2 mg once a day. In this case, the maximum permissible dosage does not exceed 0.6 mg, which must be divided into two doses. The maximum recommended single dose is 0.4 mg.

The dosage must be selected individually depending on the patient’s body’s response to the administered drug. Physiotens can be taken regardless of meal time.

People who suffer from moderate or severe renal failure, as well as patients undergoing hemodialysis, are prescribed an initial dose of the drug in the amount of 0.2 mg per day.

If necessary, as if the drug is quite well tolerated, it is recommended to increase the dosage to 0.4 mg daily. For people on hemodialysis, the first dose of this medication should be no more than 0.2 mg per day, but over time the dosage can be increased to 0.4 mg per day.

This drug is available in the form of small round tablets, which are coated with a special film coating.

The medication contains the following components:

The active substance is moxonidine.
Additional substances - talc, titanium dioxide, povidone, crospovidone, lactose monohydrate, magnesium stearate, macrogol 6000, red iron oxide, ethylcellulose, hypromellose.

Very often the patient requires combination therapy. When Physiotensa is combined with other drugs, the following body reactions may occur:

The combined use of Physiotens with ethanol, as well as birbiturates or various anxiolytics, significantly enhances their inhibitory effect on the central nervous system.
The resulting effect when a drug is combined with alpha-blockers is determined by the dosage of these medications.
Simultaneous treatment with tablets with any of the antihypertensive drugs causes mutual enhancement of their effectiveness.
Beta-blockers in combination with the drug Physiotens cause a clinically significant increase in the development of bradycardia symptoms, and also lead to a negative ino- or dromotropic effect.
The use of Physiotens together with thiazide diuretic medications and all kinds of slow calcium channel blockers is considered completely safe for patients.
The simultaneous use of tablets with antihypertensive drugs gives a noticeable additive effect.
Tricyclic antidepressants can sharply weaken the effectiveness of antihypertensive medications, which differ in their central action, so it is better to avoid prescribing these drugs together with Physiotens.
No pharmacokinetic interaction of the drug with Moclobemide was detected.
The active substance moderately increases the manifestation of signs of cognitive impairment in people taking Lorazepam, which leads to increased sedation.

In some cases, taking the drug is either strictly prohibited, or it is allowed to be used, but only as a last resort and under the constant supervision of the treating doctor:

Manifestation of SSSU.
Individual hypersensitivity to any components of these tablets.
Obvious bradycardia.
Signs of unstable angina.
Chronic heart failure of decompensated form.
Severe liver failure.
CRF.

In addition, there are diagnoses for which patients are advised to take the medicine with extreme caution . These include the following:

Severe form of Parkinson's disease.
Development of glaucoma.
Severe epilepsy.
Patient's depression.
The so-called “intermittent” claudication.
Development of Raynaud's disease.
Pregnancy and lactation period.
Patients under eighteen years of age.

Women while pregnant should take pills only as a last resort, if the benefit to the mother significantly outweighs the possible existing risk to the health and normal development of the fetus.

It is recommended to replace Physiotens with a more gentle analogue.

During lactation, it is better to avoid breastfeeding, because the active ingredient of the drug can be excreted along with milk, entering the child’s body.

Patients may complain of a number of side effects:

Feeling of dryness in the mouth.
Headache with dizziness.
Increased fatigue of the body.
Formation of noticeable peripheral edema.
Feeling of weakness in the lower extremities.
Constant sleepiness.
A sharp decrease in blood pressure.

As recommended by manufacturers, Physiotens should be stored in a dark place with good ventilation and at moderate air temperatures.

The medicine should be kept out of the reach of small children.

The shelf life of the medicine is two years.

After the expiration date, Physiotens should not be taken!

In a Russian pharmacy, Physiotens can be purchased for about 240-500 rubles.

In a Ukrainian pharmacy such a drug will be offered for 80-170 hryvnia.

The most popular analogues of this drug include the following medications:

"Tsint";
"Moxarel";
"Tensotran";
"Moxonidine-SZ";
"Moxonidine";
"Moxonidine Canon";
"Moxogamma".

You should not change medications on your own, because this can lead to irreversible consequences.

Alexey: “Arterial hypertension gave me no rest. I tried a lot of medications, but nothing really helped. The new doctor advised me to take Physiotens. The effect appeared immediately and now high blood pressure does not scare me.”

Arseny: “This drug helped a lot. I felt dizzy for a couple of days, but then it went away. I recommend".

At the end of this article you can read other reviews, as well as leave your own.

Physiotens is a general antihypertensive drug based on moxonidine. The general effect implies that the active substance does not affect the smooth muscles of the vascular walls or the mode of operation of the myocardium, but selectively affects the nerve centers located in the brainstem and controlling the muscle tone of the blood vessels.

In addition to the active substance, the tablet contains auxiliary components: lactose monohydrate, povidone, crospovidone, hypromellose, ethylcellulose, red dye based on iron oxide, dye based on titanium dioxide and magnesium stearate. Tablets are available in three “weight categories” - containing the active ingredient 0.2, 0.3 and 0.4 mg. The 0.2 mg dosage form is pale pink, 0.4 mg is pink, and 0.5 mg is red. Regardless of the weight, the tablets are packaged in aluminum or plastic blisters of 14 pieces. 1, 2 or 7 blisters are packed in a cardboard box.

The tablet for high blood pressure Physiotens has a biconvex shape with an engraving on the side indicating the content of the active substance in milligrams. When broken, two layers of content are clearly visible.

Physiotens is taken orally regardless of food intake. It is very well absorbed in the upper gastrointestinal tract. The bioavailability of the drug is 88%. An hour after administration, the maximum content in the blood plasma is reached. A small amount of the drug binds to blood proteins (7%). The rest circulates in the bloodstream, including penetrating the blood-brain barrier into the brain stem.

Part of moxonidine is converted into a metabolite - dehydrogenated moxonidine and guanidine derivatives, which also have therapeutic antihypertensive activity.

The half-life is relatively short - 2.5 for moxonidine and 5 hours for metabolites. The drug does not accumulate in the body, so to achieve a sustainable effect it must be taken daily.

The bulk of the drug is excreted unchanged by the kidneys. The rate of elimination may be affected by the presence of chronic renal failure. If it is moderate (creatinine clearance 30 - 60 mmol/liter), the excretion rate decreases by 1.5 - 2 times and accumulation of moxonidine in tissues is observed. In severe and end-stage renal failure, physiotens is prescribed only in exceptional cases. The drug is partially eliminated from the body during hemodialysis.

In elderly patients, the natural elimination of moxonidine and its metabolites may be slowed down, but this does not cause any special consequences if the kidneys are functioning normally.

Moxonidine and its derivatives selectively interact with imidazoline receptors in the brainstem and reduce sympathetic activity. In this case, the decrease in blood pressure occurs solely due to a sympathetic decrease in the tone of the vascular walls, without in any way affecting the frequency and rhythm of heart contractions and the volume of cardiac output.

The drug has a slight effect on alpha-adrenergic receptors, which causes side effects such as dry mouth and drowsiness after taking the drug.

Moxonidine reduces cell resistance to insulin, which must be taken into account when prescribing physiotens to patients with diabetes.

At what pressure is it recommended to use Physiotens in the instructions for use? Specific indications should be established by an experienced cardiologist, but in general there is no clear definition of the boundaries of tonometer readings at which the drug is most effective. It is not an “ambulance” used for sudden increases in blood pressure and hypertensive crisis. Physiotens is usually prescribed for long-term complex therapy in combination with other antihypertensive drugs. It can also be used as a single drug.

Since it has a central effect and affects the complex mechanism of the sympathetic nervous system, treatment should not be stopped too abruptly, nor should treatment be started with the maximum dose.

The standard starting dose is one small tablet of 0.2 mg once a day. The maximum single dose is 0.4 mg, the maximum daily dose is 0.6 mg in two doses. The release of Physiotens in three weight forms allows you to apply the desired dosage in the most convenient mode.

In cases of renal failure, doses are selected individually and do not exceed 0.4 mg per day.

Physiotens combines well with alpha-blockers, thiazide diuretics, calcium channel blockers and ACE inhibitors. Upon completion of a simultaneous course of beta-blockers and Physiotens, first cancel the former, and then Physiotens.

Co-administration with tricyclic antidepressants is not recommended.

Physiotens enhances the effect of sedatives and hypnotics, so when taken once daily, it is better to drink it at night. If the drug is taken twice a day, it is better to refrain from driving vehicles and dangerous machinery.

The main contraindications are individual intolerance to the components of the drug and severe renal failure. There are no contraindications for liver diseases.

Physiotens tablets should not be prescribed to patients with galactose intolerance (a rare hereditary disease) and impaired absorption of galactose and glucose.

Use during pregnancy and breastfeeding is not recommended. Moxonidine passes into breast milk and may cause a decrease in blood pressure in the baby.

The use of Physiotens can cause:

headache, dizziness, drowsiness, nightmares, sleep disturbances;
orthostatic hypotension (artificial excessive decrease in blood pressure);
dry mouth, increased sensitivity of the tongue;
nausea, vomiting;
skin rashes, itching, local swelling;
asthenia.

Side effects are relatively rare and do not manifest themselves in life-threatening forms.

If you accidentally take large doses of the drug, headache, nausea, vomiting, abdominal pain, and a sharp decrease in blood pressure occur. Unexpected pressure surges (paradoxical hypertension) are possible. In the first two hours, it is necessary to perform gastric lavage. Then massive infusions of saline and dopamine are administered. Bradycardia is eliminated with atropine. There is no antidote; hemodialysis can only partially remove moxonidine. After the kidneys successfully reduce the concentration of moxonidine in the blood, the patient's condition stabilizes.

The owner of the trademark is the German company Solvay Pharmaceuticals. The drug is produced under license by Abbott Products GmbH, also from Germany.

Packages of 0.2 mg tablets indicate a shelf life of two years, and packages of 0.3 and 0.4 mg tablets indicate a shelf life of two or three years. Given this discrepancy, we can only recommend not to use the drug two years after purchase.

The drug should be stored at a temperature not exceeding 25°C.

The cost of Physiotens tablets depends on the mass of the active substance contained in the tablets and the number of blisters in a cardboard box. The minimum price for 0.2 mg tablets/1 blister is 232 rubles, the maximum is 280 rubles (17/20 rubles per tablet). In large packs and with 0.3 and 0.4 mg grams, the ratio does not change significantly. Moxonidine 0.3 mg tablets are more difficult to find in pharmacies than 0.2 and 0.4 mg tablets.

Physiotens is available with a doctor's prescription, although it can be purchased without a prescription in most pharmacies. Self-medication with centrally acting drugs, especially in combination with other antihypertensive drugs, is strictly not recommended!

An effective antihypertensive drug, a selective agonist of imidazoline receptors, is the drug “Physiotens”. Reviews from patients say that the product helps reduce blood pressure for diabetics and people with increased body weight.

The medicine is produced in the form of film-coated tablets. The main active ingredient is moxonindine. Auxiliary components include magnesium stearate, crospovidone, povidone, lactose monohydrate.

The active substance of the drug has a central hypotensive effect. Moxonidine in brain stem cells selectively stimulates sensitive receptors that take part in the reflex and tonic regulation of the nervous symptomatic system. The result is a decrease in peripheral symptomatic activity and blood pressure. Numerous studies (placebo-controlled, randomized, double-blind) prove the effectiveness of the drug "Physiotens". Reviews from patients confirm that the medication differs from other antihypertensive sympatholytic drugs in that it does not cause dry mouth, and there is no sedation when used.

Reviews from patients say that the tablets must be taken orally, regardless of food consumption. Typically, the drug is used in an initial daily dosage of 200 mcg. The maximum single volume of the drug should not exceed 400 mcg, the daily amount divided into two doses is 600 mcg. Patients with moderate to severe heart failure on hemodialysis are recommended to take up to 200 mcg of the drug per day. If well tolerated, the volume of the drug can be doubled.

Excessive use of the drug may cause various negative symptoms. Thus, anti-pressure tablets “Physiotens” (reviews indicate this) can cause headaches, drowsiness, and sedation. If the dosage is exceeded, blood pressure may drop significantly, pain in the epigastric region may develop, dry mouth, bradycardia, vomiting, asthenia, increased fatigue, and dizziness may occur. In addition, patients may be concerned about hyperglycemia, tachycardia, and short-term increases in blood pressure.

No specific antidotes have been developed to treat signs of overdose. In case of arterial hypotension, it is necessary to introduce dopamine and increase the fluid content in the body. Symptoms of bradycardia can be relieved with atropine. In case of overdose, it is recommended to reduce or eliminate paradoxical arterial hypertension by using alpha-adrenergic receptor antagonists.

Various drugs have a negative effect on the fetus or embryo, leading in some cases to malformations of the child. Also, the components of medications taken with mother's milk can enter the infant's body and act on it. Therefore, during pregnancy and lactation it is necessary to take medications with increased caution.

Experimental studies conducted on animals did not reveal a direct or indirect effect of the drug on pregnancy, embryonic (fetal) or postnatal development.

Like most medications, Physiotens tablets (reviews indicate this) cause negative reactions from the body. This usually occurs when using the product in maximum quantities, for a long period, or with individual intolerance to the active component.

The nervous system reacts to the use of the drug with headache, drowsiness or insomnia, dizziness. These symptoms are observed quite often. Negative reactions from the cardiac and vascular system occur in rare cases and are manifested by a sharp drop in pressure and orthostatic hypotension. In addition, after taking the medicine, patients experience dry mouth, nausea, and they may experience dermatological reactions in the form of angioedema, itching or skin rash. If there are side effects, the medication should not be discontinued; negative symptoms usually disappear after three weeks of use. However, it is still necessary to contact a specialist.

Not in all cases you can take the medicine "Physiotens". Reviews from doctors say that it is not recommended to take the medication if:

severe bradycardia (pulse rate less than 50 beats per minute);
SSSU;
hereditary intolerance or malabsorption of galactose (glucose)
lactase deficiency;
hypersensitivity to the components of the product;
children and adolescents up to adulthood.

The drug is prescribed with caution in terminal stage or severe renal failure, patients on hemodialysis, and severe liver failure.

The main diagnosis for which doctors prescribe medication is arterial hypertension. It should be borne in mind that during therapy it is necessary to systematically monitor the conditions of blood pressure, ECG and heart rate. If you need to stop taking medication, this should be done gradually.

The product does not adversely affect the ability to operate machinery and transport. However, the drug "Physiotens" (patient reviews indicate this) must be taken with caution, as it can cause dizziness and drowsiness. This fact must be taken into account by people engaged in hazardous activities that require constant concentration.

Tablets must be kept in a place where children cannot reach. If storage rules are observed (temperature up to 25 degrees C, dark, dry place), the medicine will not lose its pharmacological properties for two years. You can purchase the medication “Physiotens” (reviews confirm this) with a prescription in pharmacies. The price of a package of tablets (0.2 mg) is 275 rubles. If for some reason there is no medicine in the pharmacy, then you need to look at analogues: “Tsint”, “Moxonitex”, “Moxonidine”, “Moxogamma”.

Many patients speak of this medicine as a high-quality, effective remedy. People say that they have been taking it for many years, the drug lowers blood pressure well, and there are no side effects. Some consider the high cost of Physiotens tablets to be a disadvantage. Reviews indicate good compatibility of the drug with other hypertensive drugs.

In this article you can read the instructions for use of the drug Physiotens . Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Physiotens in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Physiotens in the presence of existing structural analogues. Use for the treatment of arterial hypertension and blood pressure reduction in adults, children, as well as during pregnancy and lactation.

Physiotens is a centrally acting antihypertensive drug.

Moxonidine (the active ingredient of Physiotens) is an antihypertensive drug with a central mechanism of action. In the brain stem structures (rostral layer of the lateral ventricles), moxonidine selectively stimulates imidazoline-sensitive receptors that take part in the tonic and reflex regulation of the sympathetic nervous system. Stimulation of imidazoline receptors reduces peripheral sympathetic activity and blood pressure.

Physiotens differs from other sympatholytic antihypertensive drugs in its lower affinity for alpha2-adrenergic receptors, which explains the lower likelihood of developing sedation and dry mouth.

Taking moxonidine leads to a decrease in systemic vascular resistance and blood pressure. The hypotensive effect of moxonidine has been confirmed in double-blind, placebo-controlled, randomized studies.

Physiotens improves the insulin sensitivity index by 21% (compared to placebo) in patients with obesity, insulin resistance and moderate arterial hypertension.

Compound

Moxonidine + excipients.

Pharmacokinetics

After oral administration, Physiotens is quickly and almost completely absorbed in the upper gastrointestinal tract. Food intake does not affect the pharmacokinetics of the drug. The main metabolite of moxonidine is dehydrogenated moxonidine and guanidine derivatives. The pharmacodynamic activity of dehydrogenated moxonidine is about 10% compared to moxonidine. Within 24 hours, more than 90% of moxonidine is excreted by the kidneys (about 78% unchanged and 13% as dehydriromoxonidine, other metabolites in the urine do not exceed 8% of the dose taken). Less than 1% of the dose is excreted through the intestines.

Pharmacokinetics in special clinical situations

Compared with healthy volunteers, patients with arterial hypertension show no changes in the pharmacokinetics of moxonidine.

Clinically insignificant changes in the pharmacokinetic parameters of moxonidine were noted in elderly patients, probably due to a decrease in the intensity of its metabolism and/or slightly higher bioavailability.

Moxonidine is not recommended for use in patients under the age of 18 years, and therefore pharmacokinetic studies have not been conducted in this group.

Indications

arterial hypertension.

Release forms

Film-coated tablets 0.2 mg, 0.3 mg and 0.4 mg.

Instructions for use and dosage regimen

The tablets are taken orally, regardless of meals.

In most cases, the initial dose of Physiotens is 200 mcg per day. The maximum single dose is 400 mcg. The maximum daily dose, which should be divided into 2 doses, is 600 mcg.

Individual adjustment of the daily dose is necessary depending on the patient’s tolerance to the therapy.

No dose adjustment is required for patients with hepatic impairment.

The initial dose for patients with moderate or severe renal failure, as well as those on hemodialysis, is 200 mcg per day. If necessary and if well tolerated, the daily dose can be increased to a maximum of 400 mcg.

Side effect

dry mouth;
dizziness;
asthenia and drowsiness;
headache;
dizziness (vertigo);
drowsiness;
fainting;
pronounced decrease in blood pressure;
orthostatic hypotension;
bradycardia;
diarrhea;
nausea, vomiting;
dyspepsia;
skin rash;
itching;
angioedema;
nervousness;
tinnitus;
backache;
neck pain;
peripheral edema.

Contraindications

sick sinus syndrome;
severe bradycardia (resting heart rate less than 50 beats/min);
2nd or 3rd degree AV block;
acute and chronic heart failure;
lactation period;
age under 18 years (due to lack of data on safety and effectiveness);
hereditary galactose intolerance, lactase deficiency or glucose/galactose malabsorption;
hypersensitivity to the active substance and other components of the drug.

Use during pregnancy and breastfeeding

Pregnancy

There are no clinical data on the use of Physiotens in pregnant women.

In animal studies, the embryotoxic effect of the drug was established.

Physiotens should be prescribed to pregnant women only after a careful assessment of the risk-benefit ratio, when the benefit to the mother outweighs the potential risk to the fetus.

Lactation period

Moxonidine passes into breast milk and therefore should not be administered during breastfeeding. If it is necessary to use Physiotens during lactation, breastfeeding must be stopped.

special instructions

Influence on the ability to drive vehicles and control machines and mechanisms

Drug interactions

The combined use of moxonidine with other antihypertensive drugs leads to an additive effect.

Tricyclic antidepressants may reduce the effectiveness of centrally acting antihypertensive drugs, and therefore their use together with moxonidine is not recommended.

Physiotens can enhance the effect of tricyclic antidepressants, tranquilizers, ethanol (alcohol), sedatives and hypnotics.

Moxonidine may moderately improve impaired cognitive function in patients receiving lorazepam.

Moxonidine may enhance the sedative effect of benzodiazepine derivatives when administered simultaneously.

Moxonidine is released by tubular secretion. Therefore, its interaction with other drugs released by tubular secretion is not excluded.

Analogues of the drug Physiotens

Structural analogues of the active substance:

Moxogamma;
Moxonidine;
Moxonitex;
Tenzotran;
Cint.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

What feedback has Physiotens received from cardiologists and patients?

Reviews from patients who have taken the drug prove that the drug is effective for the indications for which it is prescribed by cardiologists. If you believe the reviews, lowering blood pressure is a guaranteed result for any patient. However, reviews recommend starting treatment with small doses, because taking it can significantly reduce the pulse. In addition, it is not recommended to do physical work after taking it. Also in reviews, people express the opinion that even with such effectiveness, the cost of the drug is high. Due to the high price, many patients are looking for analogues.

Physiotens is a blood pressure lowering drug. In addition to hypertension, it is prescribed for various cardiovascular pathologies.

The main active ingredient in the drug is moxonidine, which explains the effectiveness and safety of the drug.

In addition to moxonidine, the tablets contain: hypromellose, povidone, magnesium stearate, ethylcellulose, titanium dioxide, lactose monohydrate, crospovidone, macrogol 6000, talc. The manufacturer offers a detailed composition for your reference in order to exclude the presence of an allergy to any of the ingredients.

Depending on the concentration of the active substance, the drug is available in different colors. For example, pale pink pills contain 0.2 mg of moxonidine, light red pills contain 0.3 mg, and if the medicine contains 0.4 mg of the component, the capsules will be red.

Thanks to this approach to dosage differentiation, patients are not confused about taking the right dose of medication and overdose is avoided. You can buy tablets in packs of 14, 28 and 96 pieces. The box contains a certain number of blisters of 14 tablets. For those who plan to start taking physiotens, instructions for use at what pressure will indicate at what time, for how long, etc.

The drug selectively acts on imidazoline receptors, which are located in the medulla oblongata. Receptors are responsible for reflexes and tonic functions of the sympathetic parts of the nervous system. Against the background of the action of moxonidine, the resistance of peripheral vessels decreases, and along with this the pressure. Unlike other drugs that are similar to alpha-adrenergic receptors, physiotens tablets do not cause drowsiness or severe drying of the mucous membrane in the throat. In addition to stabilizing blood pressure, blood pressure pills increase insulin sensitivity by 21% in overweight citizens prone to obesity and insulin resistance.

After a certain time from administration, the medicine dissolves in the upper gastrointestinal tract, then is well absorbed by the mucous membrane, penetrating into the bloodstream. The drug does not in any way affect the rate of food absorption. Over the next 24 hours, 90% of monoxidine will be excreted by the kidneys, and up to 1% will be excreted in the feces.

Physiotens works as follows:

promotes the removal of water and salt from the body;
reduces by up to 40% the activity of hormonal substances - norepinephrine, adrenaline and renin - they are the culprits of vasospasm and increased blood pressure;
increases sensitivity to insulin, as a result, the body is relieved of swelling, and the blood vessels relax.

Physiotens is a third generation drug, considered an effective representative of its group in the CIS countries and abroad. Most patients with problematic blood pressure chose this particular medicine for themselves and continue to actively take it to improve their quality of life. Among its main advantages are the following:

The use of tablets is permitted both on an empty stomach and after food. You don’t have to worry that your stomach will hurt or that food will prevent the substance from dissolving in time;
despite the fact that moxonidine does not leave the body for a long time, its effect lasts for about a day after taking the pill;
the drug can be combined with other medications for hypertension, heart pills, and diabetes;
In addition to lowering blood pressure, physiotens increases insulin sensitivity. It is considered a unique medicine for hypertension, the ability of which to reduce insulin resistance has already been proven. This is necessary for people who are overweight, have diabetes, or have metabolic disorders;
people who are overweight while using physiotensa soon noticeably lost weight - they usually manage to lose up to 4 kg in 6 months;
If you take the medicine for a long time, blood tests regarding cholesterol levels improve, the same applies to tests for the percentage of glucose and triglycerides.

The proclamation attached to the blister of tablets clearly indicates the scheme according to which physiotens should be taken. As stated, intake does not depend on food. The dosage is as follows:

at the beginning – 200 mcg per 24 hours;
one-time – maximum 400 mcg;
maximum per day – 600 mcg in 2 doses.

When prescribing physiotens, the cardiologist can adjust the dosage taking into account the reaction of the patient’s body and the effect of the pills. According to reviews, the drug is prescribed to be taken even by patients with renal failure, and it is well tolerated. The effect on patients under 18 years of age has not been studied; it is better for them to select other medications.

Like other blood pressure medications, Physiotens causes certain reactions, most of which will disappear as soon as the body gets used to the active substance. At first, you may experience the following symptoms:

drowsiness and dizziness, headaches;
a sharp decrease in blood pressure;
faintness, asthenia;
bradycardia;
nausea to the point of vomiting;
skin rash, itching;
ringing in the ears, nervousness;
pain in the neck, lower back, back;
swelling of the arms and legs.

As for contraindications, the doctor must make sure that the patient can take the pills. Prescription of the drug is excluded for the following conditions:

bradycardia, in which the heart rate is no more than 50 per minute;
weakness of the sinus node;
AV block;
acute or chronic heart failure;
drop in lactose levels in the body, galactose intolerance;
allergy to any of the components of the medicine.

As for physiotens analogues, they have approximately the same contraindications and side effects; before choosing an analogue, it makes sense to try to adjust the dosage of moxonidine and get rid of the causes that provoke the adverse reaction.

Concomitant use with alcoholic beverages and medications with a sedative effect can cause poisoning and other adverse reactions. It is definitely impossible to combine physiotens and tricyclic antidepressants, as well as tranquilizers with benzodiazepines. You should not take other blood pressure pills at the same time.

In the case when physiotens tablets are not suitable for any reason, and you plan to select another drug for blood pressure, you can evaluate the effect of the following analogues: moxogama, clonidine, estupik, moxonitex, tenoxum, albarel, tonsotran. Just don’t choose a replacement for physiotens on your own; the doctor must select the drug and dosage.

The price of physiotens depends on the size of the package, the dosage of the active substance and the region where the blood pressure medicine is sold. You can find out the cost in online pharmacies. In the end, a larger package will cost less, and if the drug is planned to be taken for a long time, this choice is completely justified. Moreover, it is not recommended to frequently change blood pressure medications - this is not very enthusiastically accepted by the body; it is better to choose only the tablets that are suitable and buy them.

Physiotens is available by prescription, like others in the group of potent antihypertensive medications. If the packaging is stored correctly, the validity period is 2 years.

Reviews about physiotens are mostly positive, this applies to both the opinions of doctors and the feelings of patients from long-term and one-time use of tablets. The medicine is normally tolerated by the body, quickly gives the expected effect, and on a regular basis allows you to achieve a stable condition without pressure surges.

Among the complaints of patients, headaches and dry mouth mucosa mainly predominate, but such reactions are usually caused by all drugs for hypertension, so it is not advisable to stop taking them. It is better to wait about 2 weeks, during which time the adverse symptoms will completely disappear or weaken and will not be too annoying. If after a while the symptoms of side effects do not go away, another medicine is selected.

It is important to know that you cannot suddenly stop taking physiotens; regular use causes an addictive effect. Therefore, you need to strictly follow the recommended dosage regimen, and if you have to stop treatment with it, act as directed by your doctor, gradually reducing the dose. This usually takes about 2 weeks. There is no official data on whether blood pressure will increase after stopping physiotension.

Take the tablets under the tongue, dissolving until dissolved. If a hypertensive crisis occurs or the pressure is excessively increased, you can take 1 tablet of the drug with water, and dissolve the second under the tongue so that the effect occurs faster.

However, there is no fundamentally big difference between oral administration and resorption. Therefore, you can take the drug in a way that is convenient for you.

Approximately 90% of cases of hypertension occur in people who are overweight and have type 2 diabetes. Physiotens and analogues can be especially useful for such categories of patients. It is prescribed in combination with other medications to immediately obtain a complex effect. More often, patients note weight loss as the most “pleasant” bonus from taking physiotens. And this is justified - the power of the main component on metabolism can only be compared with the effectiveness of diabetes medications (metamorphine, glucophage). In particular, the effect of weight loss is due, according to doctors, to the ability of physiotens to increase the sensitivity of tissues to insulin.

The characteristics of the drug listed in the article will help you understand the principle of its action and consider whether it is suitable for reducing blood pressure in a particular case. But the final decision must be made in tandem with the doctor, who takes responsibility for the well-being of the patient.

No matter how good the pills are, you should not rely only on their effect. You need to figure out why the pressure is rising and try to eliminate it. In addition, it is worth reconsidering your habits, daily routine, activity, and diet.

It is advisable to eliminate all factors that can complicate life once and for all. Such factors will be well-known: smoking and alcohol, fast food, fatty foods and soda, sweets, stress, physical inactivity. By eliminating as many of these factors as possible, you can significantly improve your health and life.

If you are a “lucky” owner of hypertension, then you should be prepared for a hypertensive crisis. Do not be afraid of it, because fear will not help you, but on the contrary, it will only worsen your condition. You need to clearly know what emergency care is needed for a hypertensive crisis at home before the ambulance arrives.

What is a hypertensive crisis? A hypertensive crisis is a sudden exacerbation of existing hypertension, which occurs for a short time. At the same time, blood pressure rises sharply. The patient begins to feel a severe headache, often in the back of the head and crown of the head, palpitations, pain in the heart, and dizziness. There is a disturbance in gait, spots in the eyes, drowsiness, nausea, and vomiting. There may be a feeling of lack of air, sometimes a disturbance of consciousness. It is not necessary that all of the listed signs be present; only some of them may be present. And you need to know that hypertensive diseases can occur at any stage of hypertension.

• increased physical activity,

• disruption of the blood pressure regulation center located in the brain.

Before emergency medical services arrive, you must:

1. Place 1 tablet of captopril (25-50 mg) or clonidine (up to 0.15 mg), or enalapril (up to 10 mg) under the tongue, which normalize blood pressure and heart rate. The medicine, which was usually previously taken by patients with hypertension, is ineffective during a crisis. If after 30-40 minutes the blood pressure does not decrease, then take another one or half tablet. You should not suddenly reduce the pressure. If the pressure has decreased by 40-60 mm Hg. Art. then we need to stop there.

If the tablets on hand do not help, I use an intramuscular injection of furosemide, a diuretic that effectively quickly reduces blood pressure. But it is often impossible to use it, since microelements such as calcium, potassium, magnesium, etc. are washed out.

Other drugs such as no-spa or dibazol are also recommended. silt and corinthos. or cordiamine. or uropidil. Uropidil is a new antihypertensive drug that has a complex effect on the body and is especially good for relieving crises in older people. Which of all these above-mentioned drugs to keep at home, as an ambulance, should be recommended to you by your attending physician.

Emergency physician, assistant at the Department of Outpatient and Emergency Care of Volgograd State Medical University Anatoly Ivanovich Bezoglazov offers physiotens and cytoflavin for hypertensive crisis. Take one Physiotens tablet orally and take one under the tongue. Below you can watch a short video with his recommendations.

2. Take a semi-sitting position and maximum peace.

3. Drink 30-40 drops of Valocordin or Corvalol. If burning pain in the chest and shortness of breath occur, which are not relieved by validol, then a nitroglycerin tablet should be placed under the tongue. If after 5 minutes the pain has not gone away, take another one.

4. Place mustard plasters on your calves and the back of your neck, and put ice on your head.

5. Place heating pads on your feet and legs or take a hot foot or hand bath (30-40 degrees) for 10-15 minutes.

6. Restore your breathing by taking a deep breath, hold it and then exhale slowly. Repeat this several times. Then relax as much as possible, do not breathe deeply and do not move actively. Breathing should be shallow.

7. Do not create panic, because fear and panic accompany an even greater increase in blood pressure. You took a medicine that will lower your blood pressure and called a doctor. The process is completely manageable and there is no need to worry.

8. From the arsenal of oriental medicine - pull with force the middle finger of first the left hand, and then the right.

Don't be afraid of nosebleeds. For hypertensive patients, this is life-saving.

If you managed to stop the crisis or it dragged on, it is recommended to completely eliminate salt from your diet for 3-4 days and control your fluid intake. You should not sharply reduce the amount of fluid consumed, since the less fluid in the body, the more it is retained by the cells and this does not lead to a decrease in edema. The rate of fluid intake should be 1.5 - 2 liters per day and there is no need to artificially reduce this volume.

the emergency care described above , it is best to regularly take preventive measures to maintain normal blood pressure. Don’t forget to monitor your blood pressure every day and follow all the doctor’s recommendations and those recommendations that you pick up by reading further articles on my blog with tips on lowering blood pressure and maintaining it at normal levels.

Continuing the topic with published articles “Blood pressure”. “Causes of hypertension.” “How to measure blood pressure correctly” and “Emergency care for a hypertensive crisis”, articles on how to lower blood pressure will be published in the coming days. If this is interesting to you, then subscribe to site updates so as not to miss them.

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Analysis of efficacy and safety of moxonidine in patients with hypertension and hypertensive crises

Arterial hypertension (AH) is the most common disease in the Russian Federation. At the same time, in our country there remains a steady trend of a steady increase in the number of emergency medical calls for hypertensive crises, which are the most serious complication of hypertension (1, 2, 3). Thus, in the Russian Federation as a whole, in recent years the number of calls from emergency medical teams for hypertensive crises (HC) has increased on average by 1.5 times, accounting for up to 20% of all reasons for calls (4.5%), and the total number of calls per year reaches 50 million (6.7).

Thus, providing effective and, at the same time, safe emergency therapy to patients with hypertensive crises remains an urgent problem that requires constant analysis and improvement. In connection with the emergence of new antihypertensive drugs and the results of randomized multicenter studies, their introduction into practice will undoubtedly help improve the prognosis and quality of life of patients with hypertension.

Unfortunately, a number of antihypertensive drugs, while effectively lowering blood pressure, can have an unfavorable metabolic effect, thereby neutralizing the positive qualities of the drugs. Thus, beta-blockers, which successfully stop the hyperactivity of the sympathetic nervous system, can worsen carbohydrate metabolism, provoking hyperglycemia (up to the development of hyperglycemic coma in patients with diabetes mellitus (8). By provoking bronchospasm, beta-blockers can worsen the course of bronchial asthma and chronic obstructive diseases .

Due to the leading role of sympathetic hyperactivity in the development of arterial hypertension and hypertensive crises, new generation sympatholytics, such as moxonidine and rilmenidine, have recently been actively introduced into clinical practice.

Sympatholytics reduce blood pressure by exerting a selective effect on the vasomotor centers of the medulla oblongata, which provide regulation of sympathetic tone (11, 12, 13). This pharmacological group originates from methyldopa and clonidine, later moxonidine (physiotens) and rilmenidine were synthesized. Due to differences in the points of application and pharmacological effects, sympathomimetics are usually divided into drugs of the first generation or “old” and drugs of the second generation or “new”.

As can be seen from table. 1 and fig. 1, methyldopa affects exclusively alpha2-adrenergic receptors located on the neurons of the nuclei of the solitary tract of the medulla oblongata. Clonidine is a mixed agonist, since, along with alpha2 - adrenergic receptors, it also has the ability to stimulate I1 - imidazoline receptors located in the ventrolateral parts of the medulla oblongata (14).

Points of application of the effects of sympatholytics

Pressure physiotens - everything you need to know:

Official instructions for use;
How to take Physiotens (moxonidine): dosages;
Indications, contraindications, side effects;
Inexpensive substitutes, analogues, including Russian ones;
Reviews from patients who are treated with these tablets;
How to stop a hypertensive crisis with physiotens.

The drug Physiotens belongs to the pharmacological group of antihypertensive drugs with a central mechanism of action. It is used to reduce systemic blood pressure in various pathologies of the cardiovascular system.

The drug Physiotens is available in the dosage form of enteric-coated tablets intended for oral administration. They are round in shape, biconvex, pale pink (200 mg dosage), pale red (300 mg dosage) or dull red (400 mg dosage) in color. The main active ingredient of the drug is moxonidine; its content in one tablet can be 200, 300 or 400 mg. It also includes auxiliary components, which include:

Macrogol 6000.
Magnesium stearate.
Lactose monohydrate.
Hypromellose.
Crospovidone.
Titanium dioxide.
Talc.
Povidone.
Iron oxide is red.
Ethylcellulose.

Physiotens tablets are packaged in blister packs of 14 pieces. A cardboard pack contains 1, 2 or 7 blisters of tablets, as well as instructions for use of the drug.

The main active component of Physiotens tablets, moxonidine, selectively has an inhibitory effect on imidazoline L1 receptors, due to which the sympathetic activity of the brain decreases, arterial vessels dilate and the level of systemic blood pressure decreases. To a small extent, the drug affects alpha2-adrenergic receptors, as a result of which it can cause the development of dry mouth and a sedative (calming) effect. Physiotens tablets do not affect the frequency and strength of heart contractions.

After taking Physiotens tablets orally, the active substance is quickly and almost completely absorbed into the systemic bloodstream. It is evenly distributed in tissues and penetrates through the blood-brain barrier into the structures of the central nervous system. Moxonidine is metabolized in the liver to form inactive breakdown products, which are excreted primarily in the urine. The half-life (the time during which half of the entire dose of the drug is eliminated from the body) is about 5 hours.

The main medical indication for the use of Physiotens tablets is arterial hypertension - a pathological condition characterized by an increase in systemic blood pressure above normal values.

There are a number of pathological and physiological conditions of the body in which taking Physiotens tablets is contraindicated, these include:

Individual intolerance to the main active ingredient or excipients of the drug.
Sick sinus syndrome, accompanied by a significant decrease in heart rate (bradycardia).
Age up to 18 years, since the safety and effectiveness of the drug for this category of patients remain unknown.

This medication should be used with caution when there is concomitant severe insufficiency of the functional activity of the kidneys or liver, during the use of hemodialysis (hardware blood purification). Before starting to use Physiotens tablets, you should exclude the presence of contraindications.

Physiotens tablets are intended for oral administration, regardless of food. Do not chew them and wash them down with plenty of water. The initial therapeutic dosage is 200 mg per day. If necessary, it is increased to 600 mg per day, while the dose is divided into 2 times. The maximum single dose should not exceed 400 mg. The duration of the course of therapy is determined by the attending physician individually for each patient.

While taking Physiotens tablets, it is possible to develop negative reactions from various organs and systems:

Digestive system – periodic nausea, dry mouth.
Cardiovascular system - excessive decrease in systemic blood pressure (arterial hypotension), decrease in blood pressure during a change in body position from horizontal to vertical (orthostatic hypotension).
Nervous system – headache, periodic dizziness, sleep disturbances with insomnia at night and drowsiness during the day, general weakness (asthenia).
Allergic reactions developing on the skin - rash, itching, characteristic swelling and rash resembling a nettle burn (urticaria), severe swelling of soft tissues with a predominant localization in the face and external genitalia (angioedema).

Manifestations of negative pathological side reactions may gradually disappear during the first week after starting to take Physiotens tablets. If such phenomena increase, you should stop taking the drug and consult a medical specialist.

Before prescribing Physiotens tablets to a patient, the doctor carefully reads the instructions and pays attention to several features of the correct use of the drug, which include:

During the course of therapy, periodic monitoring of the level of systemic blood pressure, frequency and rhythm of heart contractions is mandatory.
Before prescribing the drug, as well as periodically during the course of therapy, a cardiac electrocardiogram (ECG) should be performed.
Discontinuation of the drug should be carried out gradually, since sudden cessation of taking the tablets may lead to an increase in blood pressure.
The drug should be taken with extreme caution by patients with concomitant disorders of the breakdown and absorption of carbohydrates in the structures of the digestive system (glucose-galactose malabsorption, lactase deficiency, lactose intolerance), since it contains the carbohydrate lactose.
If it is necessary to simultaneously discontinue the drug and beta blockers, it is canceled first.
If necessary, it is possible to combine the drug with antihypertensive drugs of pharmacological groups: thiazide diuretics, beta blockers, calcium channel blockers.
The drug may interact with some medications of other pharmacological groups (tricyclic antidepressants, lorazepam), so you should warn your doctor about their possible use.
The possibility of using the drug for pregnant and breastfeeding women is determined by the attending physician individually according to strict medical indications. There is currently no data on the direct negative impact of this drug on the body of a developing fetus or infant.
Since the use of this drug may develop negative reactions from the nervous system in the form of dizziness or drowsiness, it is not recommended to perform potentially dangerous work that requires sufficient concentration and speed of psychomotor reactions.

In the pharmacy chain, Physiotens tablets are dispensed with a doctor's prescription. To avoid complications or negative health consequences, it is not recommended to take them independently without prior prescription from a medical specialist.

When the recommended therapeutic dose of Physiotens tablets is significantly exceeded, the level of systemic blood pressure decreases below normal values, a headache appears, drowsiness develops, dry mouth, a feeling of fatigue, pain in the stomach, and general weakness. Treatment is pathogenetic. It involves the administration of dopamine and restoration of circulating blood volume in a medical hospital setting.

Similar in composition and therapeutic effects to Physiotens tablets are the drugs Moxonidine, Moxonitex, Moxarell, Tenzotran.

The shelf life of Physiotens is 2 years for tablets with a dosage of 200 mg, 3 years for tablets with a dosage of 300 and 400 mg. The drug should be stored in its original original packaging, in a dark, dry place, out of reach of children, at an air temperature not exceeding +25° C.

The average price of Physiotens tablets in Moscow pharmacies depends on their quantity in the package and the dosage of the main active ingredient:

200 mg, 14 tablets – 262-277 rubles.
200 mg, 28 tablets – 501-508 rubles.
400 mg, 14 tablets – 435-483 rubles.
400 mg, 28 tablets – 726-807 rubles.

Sources: https://03-med.info/lekarstva/fiziotenz-instrukciya-pokazaniya-k-pri.html https://davleniya.info/fiziotenz-pod-yazyk-ili-zapivat/

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Contraindications and side effects

Before you start taking the drug, be sure to familiarize yourself with the contraindications for its use. This is necessary in order to protect yourself from unwanted complications and inadequate reactions to the therapy received.

So, the described drug should not be taken in the presence of the following pathologies and diseases:

Hypersensitivity to any components of the drug and the presence of allergies to it. These points should be clarified by the attending physician when collecting an allergy history (presence of episodes of intolerance to Physiotens in the past).
The presence of individual arrhythmias (syndrome of weak automatism of the sinus pacemaker and a tendency to bradycardia - reduced heart rate).
Children and teenagers up to 18 years of age.
Severe chronic dysfunction of the renal and hepatic parenchyma. In these cases, special caution is required when prescribing this medication, because studies that would study the utilization and excretion from the body in such pathologies have not been conducted.
Carrying out hemodialysis for patients to cleanse the blood of metabolic products.

Even with the correct prescription of this pharmaceutical, a number of patients who are predisposed to this may experience various complications and adverse reactions.

Side effects that may occur when using the antihypertensive drug Physiotens:

On the part of the brain, disorders can manifest themselves in the form of cephalgia, increased daytime sleepiness and sleep disturbances.
From the heart and blood vessels, hypotension, syncope and orthostatic collapse may be observed.
From the digestive tract, the patient may complain of dry mucous membranes in the oral cavity and periodic feelings of nausea.
Allergic reactions can have varying degrees of severity and manifest themselves differently in different patients. The mildest forms of hypersensitivity are considered to be rash and itchy skin. And the most severe allergies are characterized by the development of such life-threatening conditions as angioedema and anaphylactic shock.

Reviews

This pharmacological drug is quite widely used to treat patients with cardiac pathology, so you can easily find many reviews from patients who have used this medicine to correct blood pressure numbers.

Most of the responses are positive, but there are reviews that describe the drug as completely ineffective. You should not be blindly guided by the opinions of other people, since the effectiveness of the drug in each specific case depends on individual susceptibility to its components.

The final decision on starting treatment with Physiotens should be made only together with your treating doctor, who knows all the features of your clinical case.

Doctors

Ekaterina Anatolyevna, cardiologist, specialist in ultrasound examination of the heart. Physiotens is a good drug that can quickly stabilize a patient’s blood pressure. Sometimes difficulties arise in selecting the required dosages, but this has more to do with the individual characteristics of the patient, and not with the medicine itself. Several times I observed a side effect in the form of increased drowsiness, but these symptoms went away on their own and did not require any correction.
Gennady Dmitrievich, cardiologist with 15 years of experience, associate professor. The range of application of this drug is very narrow, but it works very well against arterial hypertension. Most often I prescribe these tablets as monotherapy.

Patients

Galina, 49 years old. 5 years ago I was diagnosed with hypertension, and since then I have been constantly taking pills to keep my blood pressure within normal limits. Medicines have to be changed quite often because after some time they stop working. I’ve been taking Physiotens for the last six months, and so far I’m very pleased with it. Blood pressure does not rise above 135/100, and my health is also consistently good. No headaches.
Evgeniy, 61 years old. I switched to Physiotens quite recently because the previous blood pressure pills had side effects. Now the pressure does not go above 140, even after I work in the garden. I'm happy with these tablets!

How does alcohol interact with Physiotens?

Due to its constituents, alcohol is characterized by excellent dissolution in lipid tissues at the cellular level. Alcohol tends to thin the blood and reduce the viscosity of liposomes. As a result, there is a change in the functions of the liver and kidneys. The combined use of Physiotens with alcohol is prohibited. When this medication is mixed with the latter, a negative effect occurs on the ventrolateral region in the medulla oblongata, which is responsible for respiratory function and blood flow.

When taking Physiotens and alcohol together, the following consequences are possible:

heart rate slows down or increases;
heart rate decreases;
blood pressure decreases greatly;
the heartbeat may stop;
dizziness and lethargy appear;
the central nervous system is suppressed.

When treated with Physiotens, regular alcohol consumption negatively affects the digestive system and kidney function. This occurs due to the effect of alcohol on the production of secretions in the adrenal glands. Excessive amounts of alcohol in the bloodstream interfere with the synthesis of tropic hormones by the pituitary gland in the brain. And the medicine itself leads to a decrease in the bloodstream of hormones such as adrenaline and norepinephrine. Thanks to moxonidine in the drug, the body's adaptation to insulin is reduced. In this regard, the drug is indicated for the treatment of hypertension in patients who suffer from diabetes. When drinking alcohol, the situation worsens, the endings in the pancreas are affected, which leads to a decrease in the therapeutic effect of the drug.

conclusions

The moxonidine molecule is very effective in hypertensive crises and chronic hypertension. The drug also helps normalize blood glucose levels, which is especially important since diabetes mellitus often accompanies arterial hypertension.

Long-term use of the drug is not addictive, does not lead to tachyphylaxis and does not have a negative effect on the body systems. Due to its low cost and high efficiency, the product has gained wide popularity and recognition from both doctors and patients.

Originally posted 2018-02-20 17:08:45.

Overdose

Exceeding the prescribed dosage of the drug often leads to an overdose, accompanied by the following symptoms:

abdominal pain;
headache;
difficulty breathing;
nausea;
dizziness;
impotence;
decrease in blood pressure;
urge to vomit.

Sometimes hypertension, tachycardia, and hyperglycemia additionally develop. A severe overdose can lead to death.

According to the symptoms of this condition, the patient is prescribed Atropine, Dolamine, and alpha-adrenergic receptor antagonists.

Analogues of physiotens. Tablets containing moxonidine as the active ingredient

Physiotens is a medicine that lowers blood pressure and also increases the sensitivity of cells to insulin. The instructions for use indicate that moxonidine reduces insulin resistance. This property is important for obese patients with hypertension and people suffering from type 2 diabetes.

In 2008, a large-scale long-term international study, MERSY (Moxonidine Efficacy on blood pressure reduction revealed in a metabolic syndrome population), was completed. This was a study of the effectiveness of moxonidine in lowering blood pressure in patients with metabolic syndrome, including postmenopausal women. The study involved 5864 patients, of which 272 were from Russia.

Let us remember that metabolic syndrome is when a patient with hypertension is overweight and has poor blood tests for cholesterol and triglycerides. This situation means that the risk of sudden heart attack or stroke is increased by at least 5-7 times compared to thin people with normal blood pressure.

And if there are also bad sugar tests, it means that metabolic syndrome has turned into type 2 diabetes. This is really bad. Common complications of diabetes are gangrene and leg amputation, blindness, and kidney failure.

All participants in the MERSY study were treated with physiotens, mostly in combination with other blood pressure pills. Doctors observed each patient for 6 months. They noted the effect of treatment and, if necessary, increased the dose of tablets.

According to the results of the study, it turned out that moxonidine not only lowers blood pressure, but also has a positive effect on body weight (minor weight loss), and also improves the results of blood tests for cholesterol, triglycerides and glucose.

Physiotens for blood pressure is usually prescribed in combination with other medications.

Systolic “upper” blood pressure in patients decreased by 24.5±14.3 mmHg. Art., and diastolic “lower” pressure - by 12.6±9.1 mmHg. Art. Pulse pressure decreased on average by 11.8±12.8 mm Hg. Art.

, and the pulse rate - by 5.7±8.2 beats/min. 41.3% of patients achieved target blood pressure values at the final visit to the doctor after 6 months. The dynamics of other indicators are in the table below.

Results of 6 months of treatment with moxonidine

Indicators	At first	After 6 months of treatment with physiotens
Fasting plasma glucose, mmol/l	6,8±2,1	6,2±1,6
Triglycerides in blood, mmol/l	2,4±1,1	2,0±0,9
Total cholesterol, mmol/l	5,8±1,1	5,2±0,9
“Good” HDL cholesterol, mmol/l	1,2±0,5	1,3±0,5
“Bad” LDL cholesterol, mmol/l	3,5±1,1	3,0±0,9
Creatinine in blood, mmol/l	0,09±0,06	0,10±0,07
Urine albumin, mmol/l	92,7±191,6	83,3±205,5
Body weight, kg	92,0±15,6	90,0±15,3

We suggest you read: Picamilon increases blood pressure or not

How did patients rate the tolerability of their treatment:

excellent - 44.4%;
good - 48.3%;
tolerable - 6.4%;
bad - 0.9%.

The ability of moxonidine to lower blood pressure was assessed as comparable to other first-line hypertension medications. We emphasize that the vast majority of participants in the MERSY study received a combination of several drugs for hypertension, and not physiotens alone.

Metformin, sold under the names Siofor and Glucophage, is the most popular medicine for type 2 diabetes. It increases tissue sensitivity to insulin and reduces insulin resistance. Thanks to this, the metabolism of patients with metabolic syndrome and type 2 diabetes improves.

The results of blood tests for glucose, cholesterol and triglycerides shift towards the normal range. The concentration of insulin in the blood also decreases, which was initially increased several times. Patients, although slightly, lose weight thanks to these pills, without changing their lifestyle.

Monoxidine has an effect that approaches the effect of metformin, plus it also lowers blood pressure. This was first confirmed by the results of the Russian study ALMAZ. which ended in 2006.

Physiotens and its analogues are not a cure for diabetes! It practically does not lower blood sugar. If you have type 2 diabetes, then read

this article

The ALMAZ study was conducted in 11 Russian medical centers in Moscow, St. Petersburg and Chelyabinsk. Almost 200 patients took part in it. Half of them were prescribed metformin at a dose of 500 mg 2 times a day, the other half were prescribed moxonidine at a dose of 0.2 mg 2 times a day.

Patients with hypertension and metabolic syndrome in both groups did not differ statistically in age, male to female ratio, body mass index, fasting blood sugar, glycated hemoglobin, upper and lower blood pressure.

It turned out that although both drugs lower blood sugar, metformin does it better. There is nothing surprising here. Manufacturers of physiotens and its analogues have never claimed that this drug helps against diabetes.

The difference between groups in fasting plasma glucose was statistically significant and equaled 0.35 mmol/l in favor of metformin. This was despite the fact that baseline levels of insulin resistance were similar in both groups.

In people in the moxonidine group, plasma insulin concentrations decreased slightly only 2 hours after the glucose load. After 1 and 3 hours, there was no decrease in insulin in the blood of the patients. Indicators of glycated hemoglobin initially, as already noted, were approximately the same in both groups.

Among patients treated with physiotens tablets, the HbA1C level did not change significantly. Metformin showed the best results. Its intake significantly reduced glycated hemoglobin from 6.25±0.62% to 6.05±0.62%.

The authors of the ALMAZ study indicated that neither physiotens nor metformin significantly improved cholesterol and triglyceride levels in study participants. Although, according to numerous data from other authors, taking metformin improves lipid metabolism in patients with type 2 diabetes and metabolic syndrome.

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Comparison of the hypotensive effect of physiotens and metformin

Arterial pressure	Physiotens		Metformin
Arterial pressure	At first	After treatment	At first	After treatment
Systolic “upper”, mm Hg. Art.	143±7,9	137±14,8	141±7,9	136±14,9
Diastolic “lower”, mm Hg. Art.	86±7,3	83±8,6	85±6,7	82±9,6

There was no difference between the two drug regimens in the effect on blood pressure. This is likely because the patients included in the study had only slightly elevated blood pressure. Metformin (Siofor, Glucophage) should not be considered a real cure for hypertension.

Body mass index significantly decreased both when prescribing moxonidine (from 33.6±4.7 to 33.0±4.42 kg/m2) and when taking metformin - from 34.3±6.24 to 33.3 ±5.7 kg/m2. At the same time, metformin caused more pronounced weight loss in patients who took it.

Conclusions:

Both physiotens and metformin statistically significantly increase tissue sensitivity to insulin. Metformin - mainly due to lowering blood sugar, moxonidine - mainly due to lowering insulin concentrations.
Both drugs lower blood pressure to approximately the same extent
Physiotens, like metformin, significantly reduces body mass index, i.e. patients lose weight slightly.
Metformin significantly reduces the level of glycated hemoglobin. Moxonidine, unfortunately, cannot boast of such an effect.
Taking Physiotens or Siofor (Glucophage) tablets cannot replace measures to transition to a healthy lifestyle. If you have diabetes, then follow the type 2 diabetes treatment program, without fasting and insulin injections. If hypertension is overweight, but without diabetes, then use this technique.
Both drugs are well tolerated, as confirmed by patient reviews. When prescribing moxonidine, side effects sometimes occur - headache and dry mouth. When using metformin - diarrhea, nausea and headache.

In the MERSY study, described above, postmenopausal women were divided into a separate subgroup, 3588 people. They initially had slightly higher “upper” and “lower” blood pressure, higher heart rate and total blood cholesterol than the younger women who also participated.

What results were obtained in a group of women after menopause during treatment with physiotens and other blood pressure pills:

systolic “upper” pressure decreased by an average of 27.6±13.3 mmHg. Art., from 161.5±15.5 to 133.9±12.1 mm Hg. Art.;
diastolic “lower” pressure decreased by 14.5±9.5 mm Hg. Art., from 96.6±8.1 to 82.1±7.7 mmHg. Art.;
heart rate decreased by 7.2±8.4 beats/min.

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Only 40.9% of postmenopausal women reached their target blood pressure level at the end of the study. Among women with preserved menstrual function, this figure was significantly higher – 73%. Obviously, the older the patient, the more severe the hypertension and the more difficult it is to get the blood pressure under control.

It is assumed that in older women, a lack of estrogen in the body exacerbated the severity of the disease. However, the use of hormone replacement therapy is controversial due to side effects.

Russian specialists compared physiotens and captopril for the treatment of uncomplicated hypertensive crises. The study analyzed clinical cases of 225 patients. Of these, 113 people took a physiotens tablet at a dosage of 0.4 mg to relieve a hypertensive crisis, and 112 patients took captopril at a dosage of 25 mg.

Patients were specially selected so that clinical and demographic indicators did not differ significantly. Patients in both groups had almost the same average age, height, weight, body mass, history of hypertension, baseline blood pressure, etc.

Uncomplicated hypertensive crisis:

occurs with subjective and objective symptoms of moderate severity;
pressure rises to 180/100 mm Hg. Art. or by 30% of the patient’s usual indicators;
not accompanied by acute development of target organ damage;
requires lowering blood pressure over several hours, but not immediately.

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Causes of pathology

Hypotensive conditions are always multifactorial. Normally, pressure interacts very closely with the brain: with normal blood pressure, tissues and organs are provided with a sufficient amount of nutrients and oxygen, vascular tone is normal. In addition, thanks to blood circulation, recycled waste (metabolic products) are removed in a sufficient volume, which are released by cells into the blood. When blood pressure drops, all these points are turned off, the brain starves without oxygen, cell nutrition is disrupted, metabolic products are retained in the bloodstream, and they are cause a picture of intoxication with a decrease in blood pressure. The brain regulates the process by turning on baroreceptors, which constrict blood vessels, and adrenaline is released. If the functioning of the central nervous system malfunctions (for example, prolonged stress), compensatory mechanisms can quickly become depleted, blood pressure constantly decreases, and the development of a state of fainting is possible.

Certain types of infections and their pathogens, when releasing toxins, can damage baroreceptors. In such cases, the vessels stop responding to adrenaline. Arterial hypotension can be caused by:

heart failure;
decreased vascular tone during blood loss;
various types of shock (anaphylactic, cardiogenic, painful) - with them a hypotensive effect also develops;
a rapid and significant decrease in circulating blood volume (CBV) during burns and bleeding;
the hypotensive effect can be caused by injuries to the brain and blood vessels;
excess doses of antihypertensive drugs;
poisoning with fly agarics and toadstool;
hypotensive conditions in mountain and extreme sports athletes;
for infections with complications;
endocrine pathologies;
under stress, a hypotensive effect is also observed;
hypovitaminosis;
congenital pathologies of blood vessels and organs.

Separately, we can note the change in climate, seasons, radiation, magnetic storms, and heavy physical activity.

Classification of the disease

What is hypotension? It can be acute and permanent, chronic, primary and secondary, physiological and pathological.

Primary or idiopathic - is chronic in nature, is a separate form of NCD (neurocirculatory dystonia occurs in 80% of patients, when the work of the autonomic nervous system is disrupted, and it ceases to regulate the tone of the arteries) - this is a hypotensive disease. The modern interpretation of this phenomenon is neurosis due to stress and trauma of a psycho-emotional nature of the vasomotor centers of the brain. The primary type also includes idiopathic orthostatic hypotension. In translation, this is the occurrence of collapses suddenly, without reason. Provoking factors are lack of sleep, chronic fatigue, depression, all vegetative crises (adynamia, hypothermia, bradycardia, sweating, nausea, abdominal pain, vomiting and difficulty breathing).

Secondary or symptomatic hypotension, as a symptom, appears in the following diseases:

Spinal cord injuries, hypothyroidism, diabetes mellitus, hypotensive syndrome in TBI, ICP.
Osteochondrosis of the cervical spine, gastric ulcer, arrhythmias, tumors, infections, with hypofunction of the adrenal cortex, collapse, shock, pathology of the cardiovascular system - narrowing of the mitral valve, aorta.
Blood diseases (thrombocytopenic purpura, anemia), chronic long-term infections, shaking paralysis, increased uncontrolled dose of antihypertensive drugs.
Hepatitis and cirrhosis of the liver, chronic intoxication of various origins, kidney disease and the resulting chronic renal failure, hypovitaminosis of group B, limited insufficient intake (drinking) of water, subluxation of the cervical vertebrae during somersaults).

Hypotension may occur in the following cases:

during pregnancy (due to low arterial tone - hypotensive syndrome);
in young women, adolescents with an asthenic constitution;
in athletes;
in older people, blood pressure may decrease due to atherosclerosis;
during fasting;
in children with mental fatigue, physical inactivity.

Physiological pathology can be hereditary; a hypotensive effect for residents of the north, highlands, and tropics is a normal phenomenon. In athletes, the pathology is chronic, all organs and systems have already adapted and adapted to it, it develops gradually, so there are no circulatory disorders.

There is also the concept of managed hypotension (controlled), which consists of deliberately lowering blood pressure with the help of medications. The need for its creation was dictated by large-scale surgical operations being carried out to reduce blood loss. Controlled hypotension was attractive because a lot of clinical and experimental observations showed that with a decrease in blood pressure, wound bleeding decreases - this was the prerequisite for the creation of a method first used in 1948.

Currently, controlled hypotension is widely used in neurosurgery for the removal of brain tumors, cardiology, tracheal intubation, hip replacement, and awakening after operations. The indication for its implementation is the threat of significant blood loss during traumatic and simply complex operations. Controlled hypotension has long been achieved by using ganglion blockers. Today other drugs are also used. The main requirements for them are the ability to quickly effectively lower blood pressure for a short time and without dire consequences. Controlled hypotension is also used to reduce the risk of rupture of cerebral aneurysms, arteriovenous malformations, when there is practically no capillary network, etc. They are achieved by influencing various pathways of blood pressure regulation.

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The acute symptomatic form of hypotension develops suddenly, quickly, simultaneously. It is observed in cases of blood loss, collapse, poisoning, anaphylactic and septic shock, cardiogenic shock, MI, blockades, myocarditis, thrombosis, dehydration as a result of diarrhea, vomiting, sepsis (in an organism unadapted to this, blood flow is disrupted). Antihypertensive therapy is used not only for hypertension, it is used for liver disorders, kidney diseases, rhythm disturbances, etc. Only the acute form of the disease has consequences for the body, when there are signs of bleeding and hypoxia of tissues and organs, in all other cases there are no The pathology does not pose a threat to life.

Symptomatic manifestations

Symptoms include:

lethargy, especially in the morning;
weakness, fatigue, decreased performance;
absent-mindedness, memory loss;
dull pain in the temples and frontal part of the head, dizziness, tinnitus;
pale skin;
weather sensitivity (especially to heat), signs of impaired thermoregulation - wet, cold extremities (arms and legs) at any time of the year;
increased sweating;
bradycardia;
drowsiness, fainting;
inability to tolerate travel by transport due to a tendency to motion sickness.

Hypotensive conditions require longer sleep - 10-12 hours - to restore normal well-being. And yet in the morning such people wake up sluggish. They often have a tendency to flatulence, constipation, belching air, and causeless aching pain in the abdomen. Prolonged hypotension in young women can cause menstrual irregularities.

First aid for fainting and collapse

Fainting (a short-term loss of consciousness due to insufficient blood flow to the brain) can go away on its own, but collapse requires medical intervention. With cardiac arrhythmias, dehydration, anemia, hypoglycemia, severe shocks, prolonged standing, or increased stress, hypotensive patients also develop acute hypotension, which leads to fainting. Precursors include tinnitus, dizziness, darkening of the eyes, severe weakness, and shallow breathing.

Muscle tone decreases, and the person slowly sinks to the floor. There is profuse sweating, nausea, and paleness. As a result, loss of consciousness occurs. At the same time, blood pressure drops, the skin acquires a gray tint. Fainting lasts for several seconds. The first aid in this case is to give the body a horizontal position with the leg end raised. If a person wakes up, you should not immediately sit him down, otherwise another fainting spell will follow. But if a person does not regain consciousness for more than 10 minutes, an ambulance must be called.

Unlike fainting, collapse is an acute vascular insufficiency in which vascular tone drops sharply. The main causes are myocardial infarction, thromboembolism, major blood loss, toxic shock, poisoning and infections (for example, severe influenza), and sometimes antihypertensive therapy. Patients complain of weakness, ringing in the ears, dizziness, shortness of breath, chills. The face is pale, the skin is covered with sticky cold sweat, blood pressure is low.

The difference between collapse is that the patient is conscious, but apathetic. There may also be orthostatic hypotension (develops after prolonged lying, squatting and subsequent sudden rise), its symptoms are similar to fainting, and there may be a disturbance of consciousness. In case of collapse, an ambulance is called, the patient lies with his legs raised, he must be warmed up, covered with a blanket, given a piece of chocolate if possible, and cordiamine dripped.

Diagnostic measures

To carry out diagnostics, an anamnesis is collected to identify the causes of hypotension and how long ago it appeared. To correctly assess blood pressure levels, it is required to measure it three times with an interval of 5 minutes. It is also monitored daily with blood pressure measured every 3-4 hours. The work and condition of the cardiovascular system, endocrine and nervous systems are examined. Electrolytes, glucose, cholesterol are determined in the blood, and an ECG, echocardiogram, and EEG are prescribed.

How to treat hypotension?

In case of secondary hypotension, the underlying disease must be treated. The combination of medications and other methods is a complex treatment, practiced primarily because there are not so many medications for treatment, and they do not always give the desired effect, and they cannot be taken constantly.

Non-drug methods include:

psychotherapy, normalization of sleep and rest;
massage of the collar area;
aromatherapy;
water procedures, first of all, these are various types of showers, hydromassage, balneotherapy (turpentine, pearl, radon, mineral baths);
acupuncture, physiotherapy - cryotherapy, ultraviolet irradiation, electrophoresis with caffeine and mesatone, magnesium sulfate, electrosleep;
Exercise therapy.

The following antihypertensive drugs are widely used:

Anticholinergics - Scopolamine, Sarrazin, Platiphylline.
Cerebroprotectors - Sermion, Cavinton, Solcoseryl, Actovegin, Phenibut.
Nootropics - Pantogam, Cerebrolysin, amino acid Glycine, Thiocetam. They have properties to improve blood circulation in the cerebral cortex.
Vitamins and antioxidants, tranquilizers are used.
Herbal adaptogen-stimulants - tincture of Schisandra, Eleutherococcus, Zamanikha, Ginseng, Aralia, Rhodiola rosea.
Preparations containing caffeine - Citramon, Pentalgin, Citrapar, Algon, Perdolan. The dose and duration are determined by the doctor.

Acute hypotensive conditions with a drop in blood pressure are well relieved with cardiotonics - Cordiamin, vasoconstrictors - Mezaton, Dopamine, Caffeine, Midodrine, Fludrocortisone, Ephedra, glucocorticoids, saline and colloid solutions.

Prevention of pathological condition

Prevention of hypotension includes:

Hardening of blood vessels - the walls of the arteries are strengthened, which helps maintain their elasticity.
Maintaining a daily routine, exercise in the morning.
Playing sports (tennis, parkour, skydiving, boxing are not recommended), avoiding stress, staying in the fresh air for at least 2 hours daily.
Performing massages, douches, contrast showers - these procedures cause blood flow to certain areas of the body, due to this the overall blood pressure increases.
Herbal stimulants (normotimics) - tinctures of eleutherococcus, ginseng, lemongrass have a general mild tonic effect. These drugs do not increase blood pressure above normal. They are harmless and are indicated even for pregnant women, but they cannot be taken uncontrollably, because... exhaustion of the nervous system may occur. Everything needs moderation.
Maintaining the necessary hydration - preferably green tea, medicinal infusions from bearberry, birch buds and lingonberry leaves, chamomile, lemon balm, wormwood, rose hips, angelica, tartar. You should be careful with herbs that have a hypotensive effect - motherwort, valerian, astragalus, mint.
If there is no circulatory failure, you can slightly increase your salt intake. Adequate rest and sleep of at least 10-12 hours is necessary.

If you have arterial hypotension, it is not recommended to abuse coffee - it is not something that will heal you, it becomes addictive. After a sharp narrowing of blood vessels, it causes a persistent vasodilator effect and leads to thinning of the arteriolar wall. Nicotine has a similar effect, so you should stop smoking. Patients with hypotension should always have a blood pressure monitor with them, see a cardiologist, and prevent heart pathologies. If hypotension does not cause deterioration in well-being, then treatment is not required.

How the action of the active substance is realized in the body

The active substance that provides the necessary therapeutic effect of the drug is moxonidine. It is this molecule that can influence specific imidazoline receptors responsible for the tone of the sympathetic nervous system and blood pressure levels.

In addition to the main active ingredient, the drug contains:

lactose;
povidone;
magnesium stearate;
red iron oxide;
crospovidone;
titanium dioxide.

The drug Physiotens belongs to the pharmacological group of antihypertensive drugs with a central mechanism of action.
After taking the drug, it is absorbed into the bloodstream through the mucous membrane of the proximal digestive tract. Next, having contacted blood proteins, it is delivered to the structures of the medulla oblongata, where it affects the receptors of the vasomotor center. As a result, the tone of the muscular lining of the vascular wall of the peripheral arteries decreases, and blood pressure levels drop.

There is no effect on the functioning of the heart muscle. Numerous clinical studies have confirmed the effectiveness of the drug when compared with placebo.

In addition to influencing tonometry data, the active substance can significantly improve the index of sensitivity of body tissues to insulin in the presence of insulin resistance in patients with moderate hypertension and obesity.

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Features of the drug’s effect on the body

The presented drug has no analogues among foreign or domestic drugs. It was developed by Russian doctors and began to be used at the beginning of the twenty-first century in the treatment of various pathological conditions.

The main unique properties of the drug, which determine the characteristics of its effect on the body, are:

protection of tissues of internal organs from oxidation by harmful substances;
reducing the feeling of anxiety, restlessness that arises against the background of constant worries, participation in stressful situations;
improvement of blood circulation processes in the brain;
activation of brain activity;
improvement of mnestic processes, concentration;
relieving convulsive syndrome;
improving the process of supplying oxygen to the cells of internal organs and tissues;
relief of insomnia, restoration of night sleep, lack of drowsiness during the day.

The main form of release of the drug is tablet and injection. Usually, a specialist decides what to prescribe - tablets or injections, based on the identified disorders in the body.

Taking such a remedy on your own is strictly prohibited. Moreover, it is worth studying in detail the issue of compatibility of Mexidol and alcohol.

Alcohol compatibility

The fact that Mexidol is used as a medicine for alcoholism misleads many people suffering from addiction into thinking that drinking alcohol is not prohibited. They explain this by the fact that the drug has a beneficial effect on the body, protecting it from harmful substances obtained with alcohol.

However, specialists of a narrow profile argue with these statements, proving that such a proximity of these substances in the body is extremely undesirable:

Do not forget that medicine is a synthetically produced substance, which is primarily responsible for the restoration of tissues and cells, and only then for their protection. It can be a salvation in situations such as a severe hangover or the onset of withdrawal symptoms, but it cannot completely protect against harmful substances and their absorption into the genetic material. It is impossible to predict what the body’s reaction will be when absolutely opposite substances, such as Mexidol and alcohol, are combined in it.
The main reason for refusing to drink alcohol in combination with this drug is the fact that the brain does not work fully. This is especially true in cases of traumatic brain injury or even disruption of blood flow in this area. In such situations, it is not only difficult to determine what is actually happening to the patient, but it is also impossible to provide him with medical assistance, since most of the drugs are not compatible with alcoholic beverages.

You can support the body with special drugs as much as you like, but sooner or later even they will cease to support the normal functioning of the liver, stomach and other internal organs.

Use of the drug in the treatment of alcoholism

Due to its unique properties at the treatment level, Mexidol interacts well with alcohol. More precisely, the instability of the patient’s emotional background decreases, mnestic functions improve, and with them the quality of life, which suppresses the alcoholic’s desire to drink.

The main indications for the use of the drug in the treatment of alcoholism are:

severe form of alcohol withdrawal;
alcoholic encephalopathy;
the occurrence of epileptic seizures;
the occurrence of damage to the nervous system, especially its peripheral part;
pathological conditions of the brain;
severe form of poisoning with ethanol and other harmful substances contained in alcohol;
the appearance of panic attacks and anxiety due to an unstable emotional background.

When taking the medicine, the process of relieving the patient’s serious condition that occurs when abruptly quitting alcohol begins. The drug helps to cope with the lack of oxygen cells that occurs against the background of hypoxia. It is extremely important that the product allows you to reduce the amount of other medications used at the time of treatment. This means that there will be much less side effects and their negative effects on the body.

Many specialists note that the effect on the body with the help of this drug gives faster results than the common traditional treatment.

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Contraindications and side effects and rules for using the drug

However, like every drug, the drug has contraindications and side effects.

Usually their role is played by:

allergic reactions;
individual intolerance to the components of the drug.

As for people suffering from alcohol addiction, they almost never experience side effects. However, there are pathological conditions in which the use of the drug is prohibited.

These include:

Kidney failure.
Liver failure.
Pregnancy.

The main side effects that appear after taking the first tablet or injection of the drug are dry mouth, nausea, and minor digestive problems, but they all disappear after a while. You should not be afraid to take medicine for fear of becoming dependent on it. Clinical trials have shown that the product is not addictive, which is why its widespread use is allowed.

There are no specific rules for taking the drug, however, there are general recommendations regarding the organization of this process.

The main ones are:

in case of severe hangover, the drug is supposed to be used in the morning after waking up;
The course of treatment is fourteen days. During this period, the use of strong drinks is not recommended, however, cases confirming the adverse interaction of the drug with them have not yet been registered.

After a patient is brought out of binge drinking with the help of medication, naturally the question arises whether he can drink. Specialists of a narrow profile are categorical about such issues.

And yet, we should not forget that only a person’s desire can help him get rid of his addiction. Not a single specialist, not a single remedy developed by doctors, no matter how wonderful it may be, will cause a complete refusal to drink stronger drinks. However, it is quite simple to reduce the state of “withdrawal” that occurs after abruptly giving up recreational drinks: it is enough to correctly use the drug, introduced a couple of decades ago.

If we are talking about the treatment of other pathological conditions, and not alcohol addiction, we should not forget that the body’s reaction to the combination of these substances has not been fully studied. The body may not react in any way, or something irreparable may happen, leading to disability or death. In any case, you should refrain from drinking alcohol, even in small quantities, until the treatment is over.

At what pressure can you take Physiotens?

For arterial hypertension, various drugs can be used to lower blood pressure with different mechanisms of action. It is worth considering Physiotens, instructions for its use, as well as at what pressure this drug should be used and what contraindications it has.

What does it help with?
At what pressure is it taken?
In hypertensive crisis
How to use
Under the tongue or with water?
Can I take it constantly?
How long does it take for it to start working?
Physiotens and alcohol: compatibility
Contraindications and side effects
Analogs
Moxonidine or Physiotens – which is better?
Physiotens or Kapoten - which is better?
Tenzotran or Physiotens – which is better?

How to take Papazol and at what pressure

Instructions for use of Valerian tablets

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Physiotens belongs to the group of centrally acting antihypertensive drugs, the main active ingredient in the composition is moxonidine. Excipients also include lactose, which should be taken into account by people with lactose intolerance. Moxonidine is an imidazoline receptor antagonist. By acting in this way, the substance helps lower blood pressure in a fairly quick time.

The drug has an extremely rapid effect on blood pressure - the maximum concentration in the blood of the main active substance is achieved in an hour or even less. At the same time, Physiotens is a product with high bioavailability. It doesn’t matter whether you take it with food or not. It will still have an effective effect on the body.

The average price of the drug is 300–400 rubles per package. Physiotens is a common representative of its category of antihypertensive drugs - you can find slightly cheaper or more expensive analogues.

What does it help with?

The official instructions for the drug say that the indications for the use of Physiotens are essential and secondary hypertension. Both cases of hypertension are quite common: essential hypertension usually develops independently, secondary - against the background of other pathologies in the body that can affect blood pressure levels.

At what pressure is it taken?

This drug should be taken if there is a constant, stable increase in blood pressure, at which point hypertension can be diagnosed. Isolated cases of increase due to physical and mental overexertion or stress are not considered in this case.

Typically, Physiotens is used for hypertensive crises, when pressure begins to increase extremely quickly, and there is a danger to human life. Since this drug begins to act within an hour after administration, in this condition it will very quickly help blood pressure levels return to normal.

In hypertensive crisis

The official instructions for use for this product do not specify whether the drug can be used for hypertensive crises, but quite a lot of people use Physiotens in this way. When stopping crises with the help of the drug, it is important to follow the daily dosages indicated in the instructions.

It is also worth remembering: if the condition of arterial hypertension is so severe that crises develop, it is important to consult a doctor as quickly as possible. A hypertensive crisis can lead to heart attack, stroke, and many other serious consequences. Sometimes it is better to call a doctor or an ambulance to stop such an attack.

How to use

The official instructions for use indicate that Physiotens is taken at 0.2 mg per day as an initial dosage, then it is increased to 0.6 mg, and they begin to divide it into two doses. The use of the medicine does not depend on meals or time of day. If the dose is large, it is better to take one part in the morning, the other in the evening, so that the intervals between them are the same.

Under the tongue or with water?

It is correct to take this drug orally with water. The tablet can be placed under the tongue only in emergency cases, when it is necessary for the effect to occur as quickly as possible.

It is worth remembering that Physiotens was not originally intended as an “ambulance” under the tongue!

Can I take it constantly?

The instructions for use for the medicine do not indicate what the duration of administration should be. The course of treatment is usually prescribed by the attending physician - each case of hypertension is individual, so it is impossible to provide the same treatment for all patients.

How long does it take for it to start working?

Since the maximum concentration of the drug in the blood is reached an hour after administration, it is after this period that Physiotens begins to act. When used under the tongue, the effect of the drug occurs faster, since the active substance enters the blood faster through the oral mucosa.

Physiotens and alcohol: compatibility

Since this drug has a significant negative effect on the liver and kidneys, you should completely abstain from alcoholic beverages during the entire treatment of hypertension. In any case, in case of such cardiovascular pathologies, it is better to completely abstain from them. It is worth remembering that alcoholic drinks can provoke deterioration in diseases of the heart and blood vessels, so you should not drink them in case of such pathologies.

Contraindications and side effects

Physiotens has several quite serious contraindications. This drug should not be used in the following cases:

For children under eighteen years of age, since there is no information about its safety.
With severe bradycardia, if the pulse is below 50–60 beats per minute, with acute and chronic heart failure.
In case of hypersensitivity to the main active ingredient of the drug or other components of the composition.
During pregnancy and breastfeeding. If it is necessary to take the medication while breastfeeding, you must interrupt lactation when you start using the drug.

Physiotens can lead to a number of side effects, but if taken correctly and in the absence of contraindications, their occurrence is extremely unlikely. Basically, this drug suppresses the nervous system and can lead to an excessive decrease in blood pressure, decreased pulse, and other similar disorders of the nervous and cardiovascular system.

Various allergic reactions, itching and skin rashes may also occur. In addition, Physiotens can lead to various muscle pain and swelling, but such side effects do not occur so often.

Analogs

The main analogues of Physiotens are other drugs based on moxonidine, for example, Moxonidine or Moxarel. Most of these analogues are slightly cheaper than this drug. It is worth remembering that, despite the similar effects, the effects of other agents on the body may differ, so you must always read the instructions for use.

Moxonidine or Physiotens – which is better?

Moxonidine is a direct analogue of this drug; it is based on the same active substance. There is no fundamental difference between the two drugs; Moxonidine is slightly cheaper than Physiotens.

Physiotens or Kapoten - which is better?

Capoten is an ACE inhibitor. This drug belongs to a different group of antihypertensive drugs, its effect differs from the effect of Physiotens. However, Kapoten is also sometimes used to relieve hypertensive crises. Only the attending physician can say which remedy is more suitable and will be better.

Possible side effects from using the drug

Like all medicines, Physiotens can cause side effects, although not everyone gets them.

Difficulty breathing, swelling of the face, lips, throat or tongue, skin rash. You may experience an allergic reaction to the medicine.
Liver problems, dark urine, pale stools, yellowing of the skin or whitening of the eyes.

These are serious side effects from Physiotens. You need urgent medical care. service!

In descending order of frequency, other side effects may include:
Dryness in the mouth area.
Headache
Feeling dizzy
Backache
Abnormal thinking
Insomnia/drowsiness
Rash/itching
Stomach upset, dyspepsia, constipation, diarrhea, vomiting
Redness
Weakness (asthenia).

Medication regimen for problem blood pressure

How to take Physiotens tablets is decided in each specific case by a cardiologist and writes an appropriate prescription. The medicine should be taken strictly as prescribed - amateur activities can harm the body.

The instructions describe the general treatment regimen:

At the beginning of therapy, the smallest dose is usually prescribed - 0.2 milligrams. If treatment does not produce results over several days, the dosage can be increased to 0.4 mg per day. If changing the dosage does not help, the doctor prescribes 0.6 milligram pills.
It is allowed to take no more than 0.4 mg of the drug at a time.
The maximum amount of the drug per day is 0.6 mg.
Patients with renal failure should be prescribed the smallest amount of the drug. The maximum amount of daily intake in these people cannot exceed 0.4 mg.

During the studies, no jumps were noted after abrupt cessation of use. Despite this, it is recommended to stop taking pills slowly, reducing their number over the course of half a month.

Throughout therapy, you need to constantly monitor your blood pressure and pulse values.

Interaction with food and alcohol

Physiotens and alcohol are not compatible. Alcohol impairs his performance and has a detrimental effect on the condition of a hypertensive patient.

You can take the medicine regardless of food intake - food does not affect the effectiveness of the components of the medicine. The pills should be taken with a small amount of water or placed under the tongue.

Interaction with other drugs

Compatibility with other tools has the following features:

Drug groups	Interaction
Antihypertensive	The hypotensive work is doubled.
Tricyclic antidepressants Anti-anxiety drugs Benzodiazepines	Physiotens doubles their sedative effect.
Lorazepam	The combination leads to impaired cognitive functions.

The product can be combined with Amlodipine, Concor. However, these drugs should be combined with caution, as they enhance each other's effects. It is necessary to select the correct dosage so that simultaneous use of medications does not lead to a strong decrease in blood pressure.

There are no data regarding the features of combining Physiotens with antibiotics. The medicine is combined with antibacterial agents. Before starting combination therapy, you need to look at the description of the antibiotic to ensure there are no contraindications or restrictions regarding Physiotens.

Interactions with other pharmacological agents

During certification of the drug, it was discovered that there was an interaction with drugs from the beta blocker group. Simultaneous use can lead to the development of severe hypotension, and therefore dynamic monitoring of heart rate and blood pressure is required.

The drug should not be prescribed simultaneously with drugs of the benzodiazepine group. Combination with medications used in the treatment of type 2 diabetes mellitus can significantly enhance the effect and reduce the dose to normalize glucose levels.

Vacation conditions and price

The average cost of Physiotens (0.2 mg tablets No. 14) in Moscow is 307 rubles. In the pharmacy chain, Physiotens tablets are dispensed with a doctor's prescription. To avoid complications or negative health consequences, it is not recommended to take them independently without prior prescription from a medical specialist.

The shelf life of Physiotens is 2 years for tablets with a dosage of 200 mg, 3 years for tablets with a dosage of 300 and 400 mg. The drug should be stored in the original original packaging, in a dark, dry place, out of reach of children, at an air temperature not exceeding +25 C.

Is it possible to drink alcohol if you have hypertension?

This question haunts the minds of all patients. Often the traditions of our country make non-drinkers social outcasts. But fortunately, hypertension is not a pathology that requires strict abstinence from alcohol.

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Alcohol and blood pressure medications - is it dangerous to mix?

An increase or decrease in blood pressure can be caused by many reasons - overwork, stress, temperature changes, magnetic storms, alcohol consumption. In the case of alcohol, the change in pressure occurs due to a sharp dilation of blood vessels.

The main danger of mixing alcohol and drugs

Blood pressure medications will help bring blood pressure into order in case of normal high blood pressure or chronic hypertension. But there is an important question: is it possible to take such drugs if your blood pressure has jumped after drinking alcohol? Situations also arise when the pill has already been taken: can you drink alcohol after that or not? Medicines for hypertension and alcohol have the same effect on the blood vessels of the body - when taken simultaneously, the effect of one component enhances the effect of the other.

Alcohol for hypertension increases the effect of the pills - but not the positive effect of the drug, but its side effects. The ethanol contained in alcoholic beverages is to blame for this, as it increases the toxicity of any medicine. Depending on the body's adverse reactions to blood pressure pills, their compatibility with alcohol can lead to serious or fatal consequences. Hypertensive drugs are divided into several classes with a specific principle of action and composition. Alcohol affects drugs in each class differently.

What specific problems will arise when mixing alcohol and medication? It all depends on the class of the hypertensive drug and the side effects related to the specific class:

Diuretics (Torasemide, Bumetonide, Priretanide). A class of diuretics that helps blood vessels constrict by removing fluid. With a mild degree of toxicity, dizziness, dry mouth, and lethargy will appear. In more severe cases, tachycardia may develop.
Beta blockers (Atram, Acridilol, Carvidil). Reduce heart rate, returning blood pressure to normal. An increase in the effect of blockers leads to severe contraction of blood vessels or complete loss of pulse.
Calcium antagonists (Amlodipine, Cardil). They relax and constrict the walls of blood vessels to normalize pressure. The negative effect on the body provokes severe dizziness and an excessive increase in heart rate.
ACE inhibitors (Lotensin, Hortil, Zocardis). Aimed at reducing the hormone that constricts blood vessels. The consequences of increased toxicity cause severe coughing and a rapid decrease in blood pressure.
Angiotensin-2 antagonists. They act as an analogue of ACE inhibitors and do not allow dilating substances into the vascular network. Undesirable effects include allergies and severe nausea.

These side effects on the body are enhanced when taken simultaneously with alcoholic beverages, so doctors and specialists urge you to avoid such mixing.

High blood pressure due to alcohol - what to do?

Strong alcohol and anti-hypertension pills should not be mixed, as this will most likely lead to undesirable consequences. How to normalize blood pressure after drinking alcohol? There are several solutions - their choice is determined by the degree of pressure increase.

When blood pressure increases by 20–25% of the original level, doctors advise using magnesium sulfate. This substance is safe for the body, but is ineffective in severe conditions. It is taken orally in the form of a suspension or administered intravenously by preparing a special solution. Magnesium will also combat hangovers and general toxicity of the body, which is why it is considered a universal cure for alcohol poisoning. The closest analogue of magnesium sulfate is Furosemide, a special antihypertensive drug that can be combined with alcohol as much as possible.

To normalize blood pressure after drinking alcohol, it is not necessary to use chemicals and pills. For a slight increase, home remedies are suitable - herbal preparations, juice or pulp of certain vegetables, prepared according to special recipes. Natural products contain many active substances that are beneficial to the body, easily digestible and do not cause allergic reactions.

If the pressure level rises sharply above 30%, you need to seek the help of specialists and call an ambulance. Otherwise, the condition may become critical and life-threatening.

Medicines to improve blood circulation

Peripheral circulation is a continuous process of blood circulation in small veins and arteries, capillaries, as well as arterioles and venules. A variety of factors lead to impaired blood circulation, including: tumors, injuries, heart and vascular diseases, kidney diseases, metabolic disorders, etc.

Signs of poor circulation may include: pain in the legs, swelling, discoloration of the limbs, headaches, hearing problems, imbalance, numbness in the limbs, etc.

Treatment of poor circulation

When blood circulation is impaired, the following diseases occur:

arterial and venous hyperemia
thrombosis
ischemia
stasis
embolism
varicose veins
Raynaud's disease

For treatment, it is necessary to accurately determine the cause and, depending on it, prescribe medication. For acute problems, surgery may be required. In addition, treatment must be combined with proper nutrition (eating foods low in fat and salt), giving up bad habits (smoking and alcohol) and undergoing special procedures to improve blood flow (vibration therapy, electromagnetic therapy, etc.).

Medicines to improve blood circulation

The following groups of drugs are used to improve blood circulation:

1) Drugs that improve microcirculation - this group of drugs acts on the vessels of the microcirculation. As a result, the vessels dilate and the blood becomes less viscous. As a rule, drugs of this group are used for circulatory disorders due to various diseases (diabetes mellitus, atherosclerosis):

radomin
chime
pentoxifylline
trental
Vasonite

2) Prostaglandin E1 drugs - drugs in this group have a positive effect on microcirculation and blood flow, and also have a hypotensive effect: vazaprostan

3) Calcium channel blockers are mainly used to improve blood circulation in the brain. Helps improve vascular microcirculation and limit damage to brain tissue. These include:

cinnarizine
logmax
nafadil
nimotop
cinnasan
brainal
norwax
arifon
cordipin
phoridon
Nifecard
cordafen

4) Low molecular weight dextran preparations - drugs of this group have a positive effect on blood fluidity by attracting additional volumes of blood from the intercellular space. These include:

rheomacrodex
hemostabil
rheopolyglucin

5) Myotropic antispasmodics - this group of drugs dilates blood vessels and relaxes smooth muscles. Myotropic antispasmodics show high effectiveness in cerebral vascular spasms:

spasmol
halidor
mydocalm

6) Herbal medicines are preparations that are created on the basis of plant materials. Herbal medicines show high effectiveness in cerebrovascular diseases, as well as in obliterating atherosclerosis and endarteritis. These include:

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bilobil
tanakan

7) Alpha adrenergic blockers - drugs of this group contribute to better blood supply to peripheral tissues. These include:

phentolamine
prazosin
sermion

Ganglion blockers - these drugs improve blood circulation in the lower extremities and also have a pronounced hypotensive effect (lower blood pressure):

pyrylene
Temekhin
dimecoline
pachycarpine

9) Bioflavonoids are substances of plant origin that increase blood flow and improve the condition of blood vessels:

venoruton
antoxide

10) Dopamine receptor stimulants - this group of drugs acts on dopamine receptors, which, in turn, leads to vasodilation. Improves blood circulation in the lower extremities - pronoran.