Instructions for use of “Polyoxidonium” for children: suppositories, tablets, nasal drops and injections to strengthen the immune system

The trade name “Polyoxidonium” hides the substance azoximer bromide, patented in Russia quite recently (in 1997). We are talking about a completely synthetic polymer, which is supposed to have pronounced immunomodulator properties. Due to little experience in using the drug, many of its properties have not yet been studied. That is why the instructions for using Polyoxidonium are still quite short and full of gaps.

However, the brevity of the instructions and the almost complete absence of contraindications for its use do not mean that Polyoxidonium is safer than other drugs. Like them, it has its own list of side effects, incompatibility with certain diseases and medications, and possible consequences of use. It’s just that at the moment they have not yet been recorded and/or studied in sufficient detail.

Other foreign analogues

Modern imported synonyms for polyoxidonium will tell you how to replace the indicated product.

• Immunal. The drug is prescribed for the prevention of acute respiratory viral infections and influenza, bacterial and viral diseases of the respiratory tract, after antibiotic therapy. Country of origin: Slovenia. The average price is 155–350 rubles.
• Dr. Theis Echinacea Tincture. An effective remedy for stimulating the body's immune response in respiratory diseases. The drug is produced in Germany. The average price is 150–280 rubles.
• Immunorm. Herbal tablets based on echinacea. Used to treat infectious diseases of the respiratory system and urinary tract. Country of origin: Germany. The average price is 143–200 rubles.
• Echinacea Ratiopharm. Active ingredient: Echinacea. The drug is produced in Germany. The average price is 240–280 rubles.

Please note that polyoxidonium is a drug that can be purchased at a pharmacy only with a doctor's prescription, with the exception of rectal suppositories.

Elements from the composition of the medicine can harm the body if used incorrectly or in the wrong dosage. The duration of the recommended course of treatment should not be exceeded. Do not be ill!

Vacation conditions and price

The average price of Polyoxidonium (12 mg tablets No. 10) in Moscow is 570 – 765 rubles. Vaginal and rectal suppositories 6 mg (10 pieces per package) can be purchased for 795–910 rubles, injections — 665–755 rubles. In Kyiv you can buy medicine for 16 hryvnia, in Kazakhstan - for 245 tenge.

In Minsk, pharmacies offer the drug for 2 bel. ruble Sold according to prescription. Tablets and suppositories are classified as over-the-counter drugs; a prescription is required to purchase the lyophilisate.

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How to prepare the product

On sale are ampoules containing powder intended for preparing a solution that is used for injections. The manufacturer explains in detail how to dilute Polyoxidonium in the instructions accompanying the medication. The contents of one ampoule must be dissolved in sodium chloride with a concentration of 0.9% or special purified water intended for injection. If you purchased a product with 3 mg of active compound in each ampoule, 1 ml of liquid is enough to dilute the drug; for a more concentrated version you need from one and a half to two milliliters. The solvent is introduced into the ampoule and the contents are allowed to swell - this takes up to three minutes. Then you need to carefully move the contents in a circular motion without shaking. If drip administration is necessary, the dose is transferred to a bag containing sodium chloride.

If you need to prepare a medication for local use, 3 mg must be dissolved in 1 ml of purified water, 6 mg in twice that volume. You can use boiled water. The liquid should be at room temperature. One drop of the finished medication will contain 150 mcg of the drug. The solution can be stored at room temperature for up to two days. The substance cannot be poured into other containers - it must be in the factory ampoule.

Features of lyophilization technology

Lyophilization technology is based on a phenomenon called sublimation. Water evaporates even when frozen, and low ambient pressure accelerates this process.

Cold drying takes place in four stages:

1. Pre-treatment of products before freezing consists of their concentration and modification of the composition. In addition, the surface area of ​​the raw material is increased and volatile solvents are removed.
2. Freezing is the main stage. In the laboratory, the prepared substance is placed in a flask rotating in a special cooling bath. Rotation allows you to significantly increase the area of ​​the product and speeds up the cryodesiccation process. Freeze dryers are used on an industrial scale. This stage is the most critical and any mistakes can easily spoil the final result.
3. Primary drying is carried out by reducing pressure and slight heating. Heat is supplied in minimal quantities so as not to destroy the beneficial properties. This process is aimed at complete sublimation of the ice; it is quite long and can last several days.
4. Secondary drying is needed to remove unfrozen water. The pressure drops even more and the temperature rises.

After all stages are completed, the pressure is normalized. The vacuum is filled with inert gases, after which the resulting substance is sealed. The water content of the finished product is quite low, ranging from 1 to 4 percent.

Due to the complexity and duration of the process, it is quite expensive. Typically, the price of lyophilisate is several times higher than products obtained using conventional spray drying.

Instructions for use

To make nasal drops from dry lyophilisate, you can add to the bottle:

• boiled water, which has been cooled to room temperature;
• saline;
• distilled water.

If a medicine containing azoximer bromide at a dose of 3 mg is used, then 1 ml of solvent is needed, and 2 ml of liquid is added to a bottle with 6 mg of the drug. As a result of this dilution, 20 and 40 drops are obtained, respectively, containing 0.15 mg of azoximer each.

For example, if the baby weighs 21 kg, then the daily dosage for him will be 21 drops. Since the product should be instilled into the nose three times a day with pauses of 1 to 2 hours, a single dose will be 7 drops.

The maximum dosage of medication per day is 40 drops. The duration of use of Polyoxidonium drops depends on the reason for the prescription. Most often, the medicine is dripped over a course of 10 days, but for the prevention of ARVI, the use can be longer (up to a month).

special instructions

You should not independently change the dosage of the drug and the duration of the course prescribed by a specialist.

There is no sufficient experience and statistical data on the use of suppositories by pregnant and lactating women, therefore, these conditions are listed in the contraindications section of the instructions.

For children

The use of Polyoxidonium suppositories is recommended from the age of 6 years.

The vaginal form is not used in pediatric practice.

Before you start using the drug, read the special instructions:

1. For children and adolescents aged 6 to 18 years, suppositories are administered only rectally.
2. If it is necessary to discontinue drug therapy, discontinuation can be carried out immediately.
3. If an allergic reaction develops, the patient should stop using the drug and consult a doctor.
4. The drug should not be used if there are visual signs of its unsuitability (defective packaging, discoloration of suppositories).
5. If you miss a single dose of the drug, you should take it as soon as possible, but if it is time to take the next dose, the dose should not be increased.

DETAILS: Dicloberl suppositories in urology

The use of the drug Polyoxidonium does not affect the ability to drive vehicles, maintain machinery and other types of work that require increased concentration and speed of psychomotor reactions.

Application nuances

The local use of Polyoxidonium powder for injections is recommended as an element of complex treatment of diseases of the ENT system. The manufacturer assures that this medication practice helps relieve unpleasant symptoms and shorten the duration of treatment. Polyoxidonium should be prescribed for acute rhinitis and sinusitis. Tests show that the use of the product helps reduce the likelihood of intracranial complications of diseases affecting the ENT system. It is believed that the use of the drug helps reduce the frequency of relapses of chronic pathologies and shorten the duration of each new episode.

In the instructions for use of Polyoxidonium accompanying the injection powder, the manufacturer mentions the fact that the qualities of the drug as an antioxidant, as well as its ability to cleanse the body of dangerous compounds, are features determined by the chemical structure of the main active compound. The drug is characterized by a high-molecular nature and a specific chemical structure of the ingredients. The molecules are such that under their influence typical immune reactions are not initiated.

Azoximer bromide is able to block toxic compounds, captures microscopic particles and optimizes the routes for their removal from the human body. This way you can cleanse your body of heavy metals and remove toxins. The drug inhibits peroxide reactions involving fatty molecules. Anti-inflammatory activity is explained not only by the antioxidant qualities of the active compound, but also by its ability to stabilize cell membranes and remove free radicals. As tests have shown, Polyoxidonium has chelating properties.

Why are Polyoxidonium suppositories prescribed?

Suppositories are often used as an element of complex therapy for acute and chronic diseases:

• viral, parasitic and fungal infections;
• acquired immunodeficiencies in HIV-infected people;
• infectious and inflammatory diseases with frequent relapses;
• pulmonary tuberculosis and its extrapulmonary forms;
• urological infections (cystitis, urethritis, pyelonephritis);
• acute and chronic forms of hemorrhoids and prostatitis;
• lesions of the herpes virus or HPV;
• allergic and autoimmune diseases;
• oncological diseases to reduce intoxication and reduce adverse reactions.

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In addition, the drug is prescribed in the following cases:

• after skin transplantation for extensive burn lesions;
• for recovery after severe injuries;
• in gynecology for the treatment of endometritis, colpitis, cervicitis or thrush.

Immunologists prescribe Polyoxidonium to elderly patients, as well as to children who are often and long-term ill (those who suffer from ARVI more than 5-6 times during the year.)

When and how much

As you can find out from the instructions for Polyoxidonium, injections are not the only way to administer the medication. The drug can also be used by injecting into the nasal cavity, under the tongue. The optimal option for use for a particular case is chosen by the doctor, focusing on the characteristics of the condition, diagnosis and individual specifics of the course of the disease. The doctor must select the frequency of use and duration of the course, and the dose size. The age group and weight of the patient are taken into account. For adults, Polyoxidonium is most often prescribed either drops into a vein or intramuscularly. Dosage per day – one or two ampoules, 6-12 mg of the drug. In some cases, it is recommended to administer the medicine every other day or a couple of times a week. The most unsaturated version of the program is the use of an immunostimulating agent once a week.

In case of acute bacterial infection, viral invasion affecting the ENT, respiratory, genitourinary systems, it is recommended to use Polyoxidonium for three days in a row in an amount of 6 mg per day, then continue the program with one injection every two days. Duration of the course – 10 procedures.

For infections and foci of inflammation in the form of a chronic disease, prone to relapses, with aggravated fungal invasion, infection with a virus or bacteria, the manufacturer recommends Polyoxidonium injections daily in the amount of 6 mg of the active compound. The duration of the first stage of the course is five introductions. The program is then continued with a dozen more procedures, administering the drug twice a week.

Use for genitourinary diseases in women

In gynecology, Polyoxidonium suppositories are used during the treatment of tumor, inflammatory, fungal, viral, and bacterial diseases of the urinary and reproductive systems. They are recommended to continue to be used during rehabilitation after surgery, chemotherapy, and radiation therapy.

In gynecology, Polyoxidonium suppositories are prescribed in case of development of:

• cystitis, urethritis, candidiasis;
• genitourinary infections of unspecified localization;
• urogenital syndrome;
• endometritis, endometriosis;
• pelvic periotonitis;
• inflammatory diseases of the vulva, vagina, uterus, ovaries, fallopian tubes;
• fibroids;
• tumors, neoplasms;
• frequent exacerbations of genital herpes;
• for fractures, thermal and other injuries in the pelvic organs in elderly women.

Polyoxidonium suppositories are included in the complex therapy regimen. In gynecology, they are prescribed together with antibiotics, systemic anti-inflammatory drugs and other drugs of general and local action. The use of suppositories alone for the treatment of sexually transmitted infections (STIs) and other pathologies of the reproductive system is ineffective. A doctor may recommend them as monotherapy only for the prevention of candidiasis or relapse of a chronic disease.

Vaginal use of suppositories

Polyoxidonium is used before bedtime after a sitz bath, shower, washing and/or douching. Girls over 18 years of age and women of all ages insert suppositories vaginally, in a lying position. The suppository should be moved closer to the cervix, like a tampon. After implantation, you should not get up immediately: it is recommended to lie down for at least half an hour.

Common schemes for using suppositories in gynecology:

• 1 suppository is inserted into the vagina daily for 10 days;
• A suppository is inserted vaginally for 3 days in a row, then once every 48 hours until the package of 20 suppositories is finished;
• A suppository is inserted into the vagina every day for 3 days, then twice a week for a month.

Girls and women during menstruation should not interrupt the course of treatment. They can administer suppositories rectally or use Polyoxidonium tablets according to the regimen recommended by the gynecologist.

Rectal use of suppositories

In gynecology, women and mature girls are prescribed the introduction of Polyoxidonium suppositories into the rectum during menstrual periods. This allows you not to interrupt the course of treatment during menstruation.

In pediatric gynecology, Polyoxidonium 6 mg suppositories are used only rectally. The active substance easily penetrates the wall of the rectum into the vagina and increases local cellular immunity.

Algorithm for rectal use of Polyoxidonium suppositories in gynecology:

• Suppositories are administered before bedtime after defecation or cleansing the rectum with a microenema.
• Before administration, wash your hands, take out a candle, and warm it in your palm.
• Lie on your side, bend your knees slightly.
• The suppository is inserted into the anus and advanced into the rectum to the length of the middle finger. If the suppository is administered to a child, the depth of insertion is checked with his finger.
• After inserting the suppository, you should not stand up for at least 30 minutes.

Suppositories are used once a day. In gynecology they are used daily, every 48 or 72 hours, once a week. During the course of treatment, 10, 15, 20 Polyoxidonium suppositories of 6 or 12 mg are administered. The doctor may prescribe a different treatment regimen.

Russian-made analogues

Cheap analogues of the drug polyoxidonium from a domestic manufacturer. The table will help you make your final choice.

Name of the drug	Average price in rubles	Characteristic
Immunomax	560–780	The immunostimulating agent is sold in the form of a solution for intramuscular administration. Applications include stimulation of weakened immunity, conditions associated with human papillomavirus.
Galavit	450–1200	The release form of the product is suppositories, tablets, injections for intramuscular administration. An immunomodulatory anti-inflammatory drug effective for infectious intestinal diseases, hepatitis, herpes, papilloma virus, burns, purulent lesions, ENT diseases and influenza.
Imunofan	480–900	The best immunomodulatory, hepatoprotective, detoxifying synonym for Russian-made polyoxidonium. It is used in the treatment of immunodeficiency conditions, infectious and inflammatory lesions, and toxic processes.
Estifan	80–120	The cheapest analogue of domestically produced polyoxidonium. The composition of the medicine includes echinacea, which is famous for its immunomodulatory properties.

Composition and effect of the drug

The main active ingredient of Polyoxidonium is ozoximer bromide. Depending on the release form, the amount of active substances and excipients differ. The maximum concentration of Polyoxidonium in the blood is achieved after 35-40 minutes. For rectal administration - after 1 hour.

Dosage form	Iosoximer bromide, mg	Excipients	Recommended patient age
Pills	12	Mannitol (E421 Mannit), povidone (Povidonum), potato starch (Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum)	from 12 years old
	6		from 3 years old
Suppositories	12	Mannitol (E421 Mannit), povidone (Povidonum), cocoa butter (Butyrum Cacao)	from 18 years old
	6		from 6 years old
Lyophilisate for injection	6	Mannitol (E421 Mannit), povidone (Povidonum), beta-carotene (Betacarotenum)	from 6 months
	3

The drug has immunomodulatory properties, helps the body fight and recover from infectious diseases of various types (bacteria, viruses, fungi), injuries, tumors, burns and autoimmune diseases. Polyoxidonium also works as an antioxidant and removes toxins.

During the disease, the virus, entering the body, multiplies at lightning speed, resulting in a local reaction. Then it spreads throughout the organs, causing a sharp deterioration in the condition and intoxication - headaches and body aches appear. The active substance Polyoxidonium blocks toxins and helps remove them as quickly as possible.

Polyoxidonium restores cells damaged during illness, saturating the body with antioxidants, improves well-being, reduces intoxication and improves immunity. The body activates self-defense, and all processes proceed naturally.

Polyoxidonium indications for use

The main purpose of using the drug is to increase the body's resistance to local and generalized infections of various natures and localizations. The mechanism of its effect is associated with the activation of the ability of leukocyte cells to phagocytose (destroy) pathogens, stimulating the production of substances that are essential for the immune system - cytokines, antibodies, lymphoid cells. In this case, the effect on the synthesis of cytokines through the drug occurs only at initially low and average levels, i.e. Polyoxidonium acts selectively.

As a result of taking the medicine, the entire immune system is activated, actively counteracting viral, bacterial and fungal infectious agents. In addition, Polyokidonium tablets have the following effects:

• antioxidant effect – binding of free radicals that damage cell membranes (including cells of the immune system);
• detoxification effect – improving the binding and removal of toxic substances and heavy metal salts from the body;
• membrane-stabilizing effect – protection and restoration of the structure and properties of cell membranes;
• hepatoprotective properties – limiting the load on the liver by binding toxins.

Due to such a wide spectrum of action in medical practice, Polyoxidonium, the indications of which are being considered, is recommended in the following cases:

• chronic and acute pathologies of an infectious-inflammatory nature, affecting the oral cavity, pharynx, tonsils, nasal appendages, auditory organs (tonsillitis, otitis media, sinusitis, etc.);
• diseases of the upper and lower respiratory tract (pneumonia, bronchitis, tracheitis, pleurisy, tuberculosis);
• allergic diseases complicated by infectious processes (including bronchial asthma, hay fever);
• recurrent herpetic infection;
• recurrent furunculosis;
• infectious diseases of the genitourinary tract (pyelonephritis, cystitis, salpingo-oophoritis, colpitis, endometritis, endocervicosis, etc.);
• prevention of post-infections in surgical patients;
• seasonal prevention of influenza and other acute respiratory viral diseases;
• HIV infection;
• congenital and secondary immunodeficiencies associated with aging or exposure to adverse factors.

The medicine is used both for prophylactic purposes and as part of complex or monotherapy for pathologies. It is worth noting that in oncology, Polyoxidonium tablets are not used, but an injectable form of the drug is used to increase resistance to infections and detoxification after chemotherapy. At the same time, this medicine has no effect on the course and prognosis of the cancer itself.

Drug interactions

Polyoxidonium is an immunomodulatory, anti-inflammatory and antioxidant agent. The active substance strengthens phagocyte cells and stimulates the formation of antibodies.

Azoximer bromide helps restore the immune system in conditions of secondary immunodeficiency that occur after infectious diseases, injuries, surgery, treatment with antibiotics and hormonal drugs, chemotherapy or irradiation of malignant tumors.

Due to the high-molecular structure of the substance, the drug has detoxifying properties (reduces the toxicity of the chemical, promotes the removal of toxins from the body and increases the stability of cell membranes).

Side effects are not described in the manufacturer's instructions, but patients sometimes complain of a feeling of bloating in the intestines when the suppositories are administered rectally and burning or itching when administered vaginally.

Polyoxidonium suppositories have a complex effect on the child’s body:

1. The antioxidant properties of the drug are due to its special structure, since due to its high-molecular nature, the azoximer intercepts free radicals.
2. The immunomodulatory effect of the drug is associated with the ability to increase the activity of natural killer cells and phagocytes, as well as stimulate the synthesis of interferons and antibodies.
3. Suppositories have a detoxifying effect, as they are able to block various toxins and activate their elimination.
4. The drug also has an anti-inflammatory effect, since it normalizes the ratio of cytokines.

Thanks to the use of suppositories, the body becomes more resistant to viral, bacterial, and fungal infections. In addition, the medication helps restore immunity in case of secondary immunodeficiencies caused by injury, surgery or infectious disease.

The drug is well tolerated by patients. In some cases, with increased sensitivity to the components of the drug, local reactions may develop:

1. Hyperemia of the vaginal mucous membranes;
2. Increased vaginal discharge;
3. Burning and itching;
4. Exacerbation of symptoms of a chronic disease in the first days of therapy.

These side effects are not dangerous and do not require discontinuation of drug treatment.

Pathologies and treatment when it will help

Intramuscularly "Polyoxidonium" is often prescribed to persons suffering from malignant diseases. The drug is used during chemotherapy and radiation, after such a course. The main objective of the program is to minimize the immunosuppressive effect and weaken the toxic effect of other elements of the program on the liver and hematopoietic system.

It is allowed to prescribe "Polyoxidonium" for infection caused by surgical intervention. The remedy is more often used in case of a systemic reaction or generalized infection. It is allowed to administer the medicine if the likelihood of infection is assessed as high - it is considered prophylactic. Ampoules of the drug containing 6 mg of Polyoxidonium are used in the treatment of patients with pulmonary tuberculosis - for this diagnosis, injections are recommended.

The drug can be used if it is necessary to activate regenerative processes against the background of a burn, injury or ulceration that does not heal for a long time. Finally, for adults, Polyoxidonium is prescribed for rheumatoid arthritis, if tests have shown infection, in a situation where the disease is caused by prolonged use of medications that suppress the immune system.

Storage conditions and shelf life

It is better to store suppositories in the refrigerator, the permissible temperature is 2... 15ºС. All medications should be kept out of the reach of children. The drug can be used for 2 years from the date of release.

Polyoxidonium suppositories can be purchased at a pharmacy with a doctor's prescription. The medicine should be stored in a cool, dark place out of the reach of children. The shelf life of the suppositories from the date of production is 2 years; after its expiration, the drug cannot be used.

Polyoxidonium tablet composition

The considered dosage form of the drug Polyoxidonium, the composition of which is represented by one active and several auxiliary ingredients, is a yellowish tablet with a scored line, without a shell. The main component is azoximer bromide, and one tablet contains 12 g of it. This is a synthetic water-soluble polymer compound that has unique properties that are confirmed by numerous studies. Auxiliary connections:

• starch;
• mannitol;
• polyvinylpyrrolidone;
• betacarotene;
• stearic acid;
• lactose monohydrate.

Release form

Polyoxidonium is produced in the form of suppositories, tablets, and injections. In gynecology, suppositories are used, which are used vaginally or rectally. The doctor will recommend how best to use it.

• Generally speaking, this is an immunomodulatory drug that helps activate the body's defenses. In addition to this function, he performs a number of other tasks that can significantly strengthen his weakened health;
• After use, women feel a surge of strength, vigor, and optimism. In other words, immunity increases and harmful substances are removed from the body. As a result, the state of health improves, and diseases do not bother you.

Polyoxidonium has three dosage forms:

• pills;
• rectal-vaginal suppositories;
• lyophilized powder.

The suppositories are torpedo-shaped, light yellow in color and have a specific smell of cocoa butter.

The tablets are flat-cylindrical, each of them has a chamfer. Their color can vary from yellowish-white to orange-yellow. The presence of slightly noticeable particles of more intense color is allowed in tablets.

Analogues of Polyoxidonium tablets

The drug in question has no substitutes for the active substance. Therefore, we list which analogues Polyoxidonium has in the form of tablets according to the therapeutic effect they provide:

• Immunal;
• Immunorm;
• Galavit;
• Arbidol;
• Esberitox;
• Cycloferon;
• Lykopid, etc.

WomanAdvice.ru

POLYOXIDONIUM - Latin name of the drug POLYOXIDONIUM

Owner of the registration certificate: NPO PETROVAX PHARM LLC

ATX code for POLYOXIDONIUM

L03AX (Other immunostimulants)

Analogs of the drug POLYOXIDONIUM according to ATC codes:

ACTINOLYSATE AMINODIHYDROPHTHALAZINDIONE SODIUM ANAFERON ANAFERON CHILDREN'S ARBIDOL ARGINIL-ALPHA-ASPARTYL-LYSIL-VALYL-TYROSYL-ARGININE ARPEFLUE AFFINOLEUKIN BESTIM BIOARON S BRONCHO-MUNAL VOBE-MUGOS E GALAVIT GALAV IT GALAVIT GALAVIT GALAVIT GEPON GLUTOXIM DIOXOMETHYLTETRAHYDROPYRIMIDINE IMMUNAL IMMUNEX IMMUNOMAX IMMUNORM IMUDON IMUNOFAN IMUNOFAN LYCOPIDE METHYLDIOXOTETRAHYDROPYRIMIDINE SULFONISONICOTINOIL SODIUM METHYLURACIL HYDRAZIDE NUCLEINATE NEOVIR SODIUM NUCLEINATE PYROGENAL POLYOXIDONIUM POLYOXIDONIUM POLUDANE REXOD RIBOMUNIL RIDOSTIN RUZAM STEMOKIN THYMUS THYMOGEN EXTRACT CYCLOFERON CYCLOFERON CYTOVIR-3 ENGIST OL ECHINACEA ECHINACEA COMPOSITUM CH All

Before using POLYOXIDONIUM you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

Immunomodulator analogues

There is only one azoximer bromide preparation on the domestic market - Polyoxidonium. This active substance is part of multicomponent drugs for the prevention of influenza.

In gynecology, doctors replace Polyoxidonium suppositories with drugs containing sodium aminodihydrophthalazindione, a combination of immunoglobulin B, M, A + interferon alpha-2b, glucosaminylmuramylpentapeptide, and other active ingredients. Good results are obtained from analogues of the immunomodulator Galavit, Tamerit, Kipbioferon, Liasten.

Analogs

A replacement for Polyoxidonium may be some other medication that has a similar effect, for example:

• . These nasal drops based on sodium deoxyribonucleinate can be used at any age. They are used both for the treatment of acute respiratory viral infections and for prophylactic purposes, since the medication activates cellular and humoral immunity, and also accelerates healing.
• IRS-19. This nasal spray contains lysates of several types of bacteria, due to which the drug stimulates local immunity. It is prescribed to babies over 3 months old for pharyngitis, rhinitis, tonsillitis and other diseases.
• Grippferon. This product, available in nasal and spray forms, contains interferon and can be used for the prevention and treatment of influenza in children from birth.

Dr. Komarovsky talks in detail about children's runny nose and medications for it.

Freeze drying in medicine

In pharmacology, lyophilisates are usually called powdered or porous forms of a medicinal product obtained by vacuum drying of liquid or soft raw materials. Before use, they are usually diluted with water to the desired consistency.

Most often, lyophilization of drugs is carried out from an aqueous solution. The use of other solvents, such as alcohol, can speed up the drying process and increase the stability of the finished extract.

Many immunostimulants are lyophilisates of certain bacterial cultures. The principle of action of such drugs is similar to vaccination. Harmful microorganisms are completely safe in small quantities. Once in the body, they force the immune system to produce new antibodies, thereby increasing its protective properties.

If a person becomes truly infected in the future, he will not get sick. A lyophilisate is often prepared to prepare a solution; it is used for intravenous and intramuscular injections. The most famous example is penicillin, which was supplied to pharmacies and medical institutions in sealed vials and diluted with water immediately before the injection.

Common lyophilisate preparations:

1. Heptor is a dry powder of ademetionine 1,4-butane disulfonate. Hepatoprotector with antidepressant activity, which is used in dissolved form for injection. Heptral is an analogue of this drug.
2. Posterisan contains inactivated Escherichia coli bacteria. Used in proctology. Helps in treating problems in the anorectal area, stimulates the immune system, reduces inflammation and promotes tissue regeneration.
3. Cortexin is a nootropic and psychostimulant. It is used for traumatic brain injuries, circulatory disorders in the brain, and epilepsy.
4. Polyoxidonium is an immunomodulator for intramuscular administration.
5. Bifidumbacterin is an immunostimulating bacterial preparation containing live bifidobacteria. Used for intestinal disorders.
6. Bronchomunal is a prophylactic agent for the prevention of respiratory diseases. Contains a mixture of lysates of several bacterial cultures, packaged in capsules.
7. Phosphogliv is a hepatoprotective agent.
8. Uro-vaxom is a bacterial lysate of 18 strains, which is used to prevent relapses if there is a chronic infection of the genitourinary system.
9. Floragin is a set of lactobacilli. It is used in gynecology to normalize vaginal microflora and prevent inflammatory processes and infections.
10. Herpetad is necessary for the treatment of primary genital herpes and its relapses. Available in the form of tablets, lyophilisate for infusion, and also in the form of a cream.
11. Xefocam is also introduced into the body by injection. This is a non-steroidal anti-inflammatory drug with an anesthetic effect. Xefocam is used to relieve moderate to mild acute pain.

This is only a tiny particle of all drugs for the production of which lyophilization technology is used. Despite the fact that the cold drying method has been around for more than a century, it has been successfully used to produce new medicines that improve the quality of life.

Foreign analogues

Popular foreign substitutes for Polyoxidonium include Wobenzym, Trimunal, Immunal. The drugs are used in various fields of medicine: gynecology, surgery, gastroenterology, pediatrics, therapy, neurology.

Wobenzym

Many patients prefer to take tablets from a German manufacturer instead of Polyoxidonium. They are time-tested and have numerous positive reviews. The medication contains components of animal and natural origin.

The tablets contain enzymatic substances:

• pancreatin,
• lipase,
• amylase,
• chymotrypsin,
• papain,
• routine,
• bromelain,
• trypsin.

The list of uses of the drug is wide. It is used in almost all areas of medicine and is a universal immunostimulant with anti-inflammatory effects.

Wobenzym copes well with infections during complex therapy. It can be replaced with Polyoxidonium in the treatment of sexually transmitted infections, HPV, and in maintenance therapy against HIV and AIDS. Wobenzym helps you recover as quickly as possible after surgery.

The medicine is contraindicated in patients:

• under 5 years of age;
• individual allergic reaction;
• hemodialysis;
• kidney pathologies;
• hemophilia.

The cost of packing Wobenzym tablets is 200 pcs. will cost the patient 1500-2000 rubles.

Trimunal

Manufacturer: Republic of Belarus. The analogue is included in the list of popular cheap substitutes for Polyoxidonium. The drug contains herbal ingredients:

• liquorice root;
• ginseng root,
• echinacea extract.

The product is used for:

• cerebrovascular accidents;
• asthenic syndrome;
• colds;
• memory disorders;
• immunodeficiency states.

Trimunal has a pronounced anti-inflammatory, immunomodulatory, and restorative effect.

Unlike other analogues, it has a wide list of contraindications:

• severe atherosclerosis;
• arterial hypertension;
• hypersensitivity to components;
• cardiac dysfunction;
• nervous excitability;
• insomnia;
• pregnancy;
• age up to 12 years;
• breastfeeding period.

The average cost of an analogue is 250 rubles.

Immunal

Slovenian drug with immunomodulatory action. Contains echinacea extract. Available in the form of injection solution and tablets. Suitable as an adjuvant in complex therapy with antibiotic drugs. It is used as an analogue of Polyoxidonium for the prevention of influenza, colds, and viral infections.

Contraindications for use:

• blood diseases;
• hypersensitivity to echinacea;
• progressive autoimmune and systemic diseases;
• STIs (sexually transmitted infections);
• lactation period;
• lactation;
• allergic diseases;
• age up to 12 years;
• deficiency, lactose intolerance.

Immunal should be taken with caution by patients with diabetes. The analogue has a wide list of adverse reactions that occur due to incorrect dosage, self-administration

Patients experience: nausea, dizziness, low blood pressure, skin rash, itching.

Sources:

Vidal: https://www.vidal.ru/drugs/polyoxidonium__6912 GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=5f06dd24-0404-4fd9-b8c8-0893254c128d&t=

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Use during pregnancy and lactation

All dosage forms of Polyoxidonium (injections, tablets and suppositories) are contraindicated during pregnancy and breastfeeding, since there is no objective data on the effect of the drug on the condition of the woman and the fetus. Also, an absolute contraindication to the use of Polyoxidonium in any form (injections, tablets or suppositories) is the presence of individual intolerance or hypersensitivity to the drug.

Polyoxidonium suppositories and injections cannot be used for children under six months of age, since there is no objective data on the effect of the drug on babies under 6 months. Polyoxidonium tablets are contraindicated for use before the age of 12.

A relative contraindication to the use of Polyoxidonium injections, suppositories or tablets is acute renal failure, in the presence of which the use of the drug is allowed, but under close medical supervision and monitoring of the person’s health status. Polyoxidonium tablets should also be used with caution in people suffering from lactose intolerance, lactase deficiency and malabsorption syndrome.

Russian analogues

Modern Russian-made analogues differ in cost and form of release. At the pharmacy you can purchase more than 3 time-tested drugs with properties similar to Polyoxidonium.

Immunomax

It is a popular analogue of the drug Polyoxidonium. The immunomodulator is widely used in the treatment of HPV - human papillomavirus, sexually transmitted infections, and viral pathologies. It can be used as a prophylactic against infectious diseases. It is used in the treatment of AIDS, HIV, as a means of supporting the immune system.

The composition of the drug includes:

• acidic peptidoglycan;
• sodium chloride.

Immunomax is produced by Russia. It has a single form of release - white powder for injection. Injections are given intramuscularly or IVs are placed.

The drug has contraindications:

• lactation period;
• age up to 12 years;
• allergic reaction to components.

Immunomax is not suitable for replacement when it comes to treating a child. The medication is used in the treatment of children of secondary school age. Polyoxidonium can be used in children from six months of age.

Among the adverse reactions of Immunomax are allergic reactions. They occur if the dosage prescribed by the doctor is not followed, or contraindications for use are violated.

To prepare injections, 1 ampoule of the drug is diluted in 1 ml of prepared liquid (saline). The course of treatment is no more than 10 days. It includes:

• the first 3 days – 1 injection per day;
• break of 4 days;
• For the remaining 3 days, injections are given in the same way as for the first 3 days.

The dosage and course of treatment may vary depending on the doctor’s indications, the patient’s condition, and the severity of the disease. The cost of the analog varies from 500 to 900 rubles, depending on the dosage.

Imunofan

An immunomodulator used not only in pediatrics and general practice, but also in veterinary medicine. The drug is designed to increase the body's defenses.

Indications for use are:

• diphtheria;
• psoriasis;
• sexually transmitted infectious diseases;
• bronchial obstruction syndrome;
• hepatitis B and C;
• as part of complex therapy for HIV/AIDS;
• HPV;
• prophylactic for children and adults;
• oncological diseases.

If we consider domestic analogues of Polyoxidonium suppositories, Imunofan is one of the popular and effective. The medicine is used in the treatment of children from 2 years of age. The main active ingredient is a synthetic derivative of thymopoietin.

Contraindications:

• patient age under 2 years;
• pregnancy and lactation period.

Among the adverse reactions, there is an allergic reaction that occurs from an overdose or hypersensitivity to the components of the drug. The average cost is 450 rubles.

Galavit

Modern Russian substitute for Polyoxidonium. Contains synthetic components aimed at restoring and maintaining the immune system. Available in the form of tablets, suppositories and powder for injection. In addition to immunomodulatory properties, the medication has an anti-inflammatory effect.

Contraindications for use:

• children under 6 years of age;
• lactation and pregnancy;
• individual intolerance to components.

Side effects occur more often when using injections. Adverse reactions occur due to overdose, incorrect treatment regimen, long-term therapy, or individual reaction. If a patient is looking for cheaper analogues of Polyoxidonium tablets, you can opt for the time-tested Galavit. Its cost does not exceed 350 rubles.

Contraindications

Not all patients can take this medicine. An absolute contraindication to the use of azoximer bromide is an allergy to any component of the drug. Possible intolerance to starch, stearic acid and substances included in the tablet shell. Before using tablets, injections or rectal suppositories, you should carefully study the instructions and composition.

Polyoxidonium in the form of suppositories

Other contraindications:

• Childbearing and lactation period.
• Severe renal failure.
• Congenital lactase deficiency.
• Glucose or galactose intolerance.
• Age up to 3 years.

If the patient suffers from mild or moderate renal failure, the doctor must select a safe dosage of the drug.

Viferon or Polyoxidonium which is better

The action of this drug, like most Polyoxidonium analogues, is also based on the production of interferon at the physiological level. The active substance of Viferon is recombinant human interferon, auxiliary components: ascorbic acid, tocopherol acetate, cocoa butter. Produced in the form of suppositories (rectal suppositories) by Russian pharmacological agents.

Viferon is an immunomodulator with a pronounced antiviral effect. It is used as part of complex therapy, including infectious and inflammatory therapy in premature and newborn babies.

Note! Possible use in children makes this drug stand out in the line of Polyoxidonium analogues.

Prescribed for the treatment of influenza, pneumonia, meningitis, viral hepatitis type B, C, D, herpetic infections of the mucous membrane and skin, as well as genitourinary diseases: ureplasmosis, chlamydia, cytomegallovirus, trichomoniasis, gardenerellosis, papilloma virus, bacterial vaginosis, mycoplasmosis, candidiasis.

Viferon can be combined with any medications and enhances the effect of antifungal and antimicrobial drugs. No contraindications other than individual intolerance have been identified. Viferon is available in pharmacies without a prescription.

Contraindications and side effects

Polyoxidonium belongs to the group of agents that have immunocorrective and detoxification effects.

Side effects of using tablets and suppositories are hypersensitivity reactions. When the drug is administered intramuscularly, some patients may experience redness and soreness at the injection site. After the first injections of Polyoxidonium, body temperature may increase.

Polyoxidonium can be used in combination with antibiotics, antiviral and antihistamines, antimycotics, cytostatic, glucocorticosteroid and bronchodilator drugs, β-adrenergic stimulants.

If it is necessary to administer the solution by drop method into a vein, it should not be diluted with infusion solutions that contain proteins.

Before using the drug, you need to find out whether it is right for you or not. Information about it is indicated in the annotation; all you have to do is apply it to yourself and discuss this situation with a gynecologist.

• There are no serious restrictions as such. The only point is individual intolerance to the components. If you are allergic to them, you should discuss this issue with your gynecologist;
• The use of candles does not affect the ability to drive a car or concentrate on important tasks. Therefore, you can freely engage in mental activity without fear for the result. The medicine will not affect her.

The medicine helps solve several problems at once, this certainly attracts patients. At the same time, one should not discount the fact that it is better to discuss the issue with the doctor a hundred times than to prescribe treatment for yourself in the hope of making it better. This approach often causes more trouble than it is worth.

Indications

Polyoxidonium drops are included in the treatment complex for:

• acute inflammatory processes in the nasopharynx and respiratory tract, caused by a viral, bacterial or fungal infection;
• acute allergic reaction accompanied by infection;
• exacerbation of chronic infectious diseases, for example, adenoiditis, sinusitis or rhinitis.

Polyoxidonium in drops is used on its own to prevent influenza and other acute respiratory infections caused by viruses.

In addition, the medicine can be dripped to prevent infectious complications in the postoperative period (after interventions in the area of ​​ENT organs).

Overdose

Suppositories are administered vaginally or rectally in accordance with the recommendations of the attending physician (daily, every other day or twice a week).

Preventive course - 10 suppositories of 6 mg or 12 mg every other day.

With a standard regimen of use, adult patients are prescribed 1 12 mg suppository once a day for 3 days, then 1 suppository is administered every other day (10, 15 or 20 suppositories per course). The dosage may be adjusted; The maintenance course of treatment (1-2 times a week) is sometimes extended to 3 months, and for cancer patients after radiation therapy or patients with immunosuppressive conditions (HIV-infected) - up to 1 year.

Children's dosage - 6 mg; course - 10 procedures.

Repeated courses of treatment can be carried out after 3-4 months, without reducing the effectiveness of the drug.

The procedure is best done at night; Before placing a suppository in the rectum, you must empty your bowels and wash your hands thoroughly.

In the treatment of gynecological diseases, depending on the degree of damage, Polyoxidonium can be administered intravaginally and rectally. Vaginal suppositories are not used during menstruation; during this period it is recommended to insert suppositories into the rectum.

Facts of complications after an overdose are not officially registered, but you should not violate the treatment regimen prescribed by your doctor.

The instructions for use indicate that Polyoxidonium is intended for rectal and intravaginal administration, 1 suppository 1 time per day. The method and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process. The drug can be used daily, every other day or 2 times a week.

1. Suppositories 12 mg are used rectally and intravaginally in adults.
2. Suppositories 6 mg are used in children over 6 years of age only rectally; in adults - rectally and intravaginally.

Rectally, suppositories are inserted into the rectum after cleansing the intestines. Intravaginally, suppositories are inserted into the vagina in a lying position, 1 time/day at night.

Standard application:

• 1 suppository 6 mg or 12 mg 1 time/day daily for 3 days, then every other day a course of 10-20 suppositories.
• If necessary, the course of treatment is repeated after 3-4 months. The need and frequency of subsequent courses of therapy are determined by the doctor; if the drug is re-prescribed, the effectiveness does not decrease.
• Patients with chronic immune deficiency (including those receiving immunosuppressive therapy for a long time, with cancer, HIV, and those exposed to radiation) are recommended to undergo long-term maintenance therapy with Polyoxidonium from 2-3 months to 1 year (adults 12 mg, children over 6 years old - 6 mg 1-2 times a week).

Options for recommended regimens of use as part of complex therapy:

• For acute infectious processes and to activate regenerative processes (fractures, burns, trophic ulcers) - 1 suppository daily. The course of treatment is 10-15 suppositories.
• For chronic infectious and inflammatory diseases in the acute stage - according to the standard regimen, in the remission stage - 1 suppository of 12 mg every 1-2 days, a total course of 10-15 suppositories.
• During chemotherapy and radiation therapy of tumors, 1 suppository is started to be administered daily 2-3 days before the start of the course of therapy. Further, the frequency of administration of suppositories is determined by the doctor depending on the nature and duration of chemotherapy and radiation therapy.
• For pulmonary tuberculosis, the drug is prescribed according to the standard regimen. The course of treatment is at least 15 suppositories, then it is possible to use maintenance therapy of 20 suppositories per week for up to 2-3 months.
• For rheumatoid arthritis - suppositories 12 mg (in adults) and 6 mg (in children), every other day. The course of treatment is 10 suppositories.
• For rehabilitation of frequent (more than 4-5 times a year) and long-term ill people and rheumatoid arthritis - 1 suppository every other day. The course of treatment is 10-15 suppositories.

DETAILS: Urological collection for prostatitis - Prostatitis

As monotherapy:

• To correct secondary immunodeficiencies, prevent influenza and acute respiratory infections, the drug is prescribed according to the standard regimen.
• For gynecological diseases, the drug is prescribed rectally and intravaginally according to the standard regimen.
• For seasonal prevention of exacerbations of chronic infectious diseases and for the prevention of recurrent herpetic infections, the drug is used every other day in adults, 6-12 mg, in children - 6 mg. Course - 10 suppositories.

If you miss a single dose of the drug, you should take it as soon as possible, but if it is time to take the next dose, the dose should not be increased.

There is no data on an overdose of Polyoxidonium in the form of tablets and suppositories. When using the solution in prescribed therapeutic doses, cases of overdose were also not recorded. Potentially increased side effects.

If signs of overdose appear, symptomatic therapy is recommended.

Description of the effect

The manufacturer indicates in the instructions for use accompanying the Polyoxidonium ampoule that azoximer bromide directly affects the cellular structures responsible for phagocytosis, and also corrects the work of natural killer cells. At the same time, the main ingredient of the drug activates the generation of antibodies in the human body. The azoximer compound affects the production reaction of alpha and gamma interferons, speeding it up and making it more effective. As a result, a pronounced antiviral effect appears. Thanks to this feature, “Polyoxidonium” can be recommended to people suffering from acute respiratory viral infections and influenza. The drug is often prescribed as a preventative when there is an increased likelihood of these diseases.

As can be concluded from the instructions for use accompanying the Polyoxidonium ampoule, the powder contained in the bottles can be used under the tongue and inside the nasal cavity, and not only as a base for preparing an injectable liquid. If you choose this format of application, you can quickly activate the body’s local ability to protect itself from an infectious agent. The substance activates neutrophils and macrophages, due to which the bactericidal qualities of blood become higher. At the same time, the cells’ ability to absorb bacteria is enhanced. Substances secreted by the salivary glands and mucous membranes of the nasal cavity become more active against pathological dangerous forms of life.

Description of the drug Bifidumbacterin

Bifidumbacterin is a typical representative of an immunobiological drug, for the production of which the lyophilization method is used. It represents dehydrated cultures of bifidobacteria.

In appearance, it is a beige crystalline mass with a grayish tint and a specific odor, which is a lyophilisate. The bacterial content in one dose of the drug is at least 10 million. When dissolved in water, it forms an opaque suspension.

The effect of the drug is based on the fact that when bifidobacteria enter the gastrointestinal tract, they suppress the growth of pathogenic microorganisms. The state of intestinal microflora is normalized, metabolism is improved and the occurrence of intestinal disorders is prevented.

Indications for use:

• acute intestinal infections;
• complex treatment of children with pneumonia, sepsis and purulent-inflammatory processes;
• acute and chronic inflammation of the large and small intestine, occurring against the background of a violation of the internal microflora;
• intestinal dysfunctions that occurred after undergoing antibacterial, chemical or radiation therapy;
• too early transition of newborns to artificial feeding;
• premature and weak children with anemia, rickets, diathesis and whooping cough;
• pregnant women who are at risk and have impaired vaginal secretion;
• bacterial colitis.

Before use, the dry lyophilisate is diluted with water at the rate of 1 dose per 1 teaspoon of boiled water at room temperature. Taken 20 minutes before meals, and given to infants immediately before feeding. It is worth noting that according to the instructions for use of Bifidumbacterin lyophilisate, the preparation of the medicine must be done immediately before administration. Storage of the finished solution is not allowed.

To treat the nipple and areola, the finished product is applied with a sterile swab 20 minutes before feeding. For intravaginal administration, a drug-impregnated tampon is placed in the vagina for 2 hours.

Before use, be sure to consult a doctor and carefully study the instructions for the drug. The price of the drug in the Russian Federation is about 150 rubles.

How to take Polyoxidonium tablets

After determining the diagnosis, severity and severity of the pathological process, the doctor can recommend how to take Polyoxidonium in each specific case. Taking pills is carried out in two ways:

• orally - by swallowing whole with water;
• sublingual - dissolution in the oral cavity under the tongue.

Is it possible to take Polyoxidonium during illness?

Polyoxidonium, the use of which is justified for a variety of infectious diseases, can be used both during the period of remission of chronic diseases and in the acute phase. Due to the use of this medicine, the degree of damage to healthy tissues is significantly reduced, toxic effects are reduced, and the duration of the disease is reduced. It is most effective when administered simultaneously with etiotropic drugs that eliminate causative pathological factors.

Is it possible to take Polyoxidonium with antibiotics?

When considering how to take Polyoxidonium correctly, many are interested in the possibility of taking these tablets in parallel with antibiotic drugs. The instructions for this medicine indicate that it is compatible with many medications, including antibiotics. Polyoxidonium can be prescribed both after and before taking antibacterial agents, which helps achieve more effective elimination of the pathogen from the body.

In addition, Polyoxidonium (tablets) can be used in complex therapy with antiviral drugs, antimycotics, antiallergic drugs, bronchodilators, beta-agonists, and hormone-containing drugs. In some cases, by taking the immunomodulator in question, it is possible to reduce the dose of one of the listed medications taken together several times or shorten the duration of therapy.

How often can you take Polyoxidonium?

When prescribing Polyoxidonium tablets, the dosage is selected taking into account several factors: the patient’s age, type of disease, severity and phase of the disease, individual characteristics of the body and concomitant pathologies. Often the drug is used daily in 1-3 doses of 1-2 tablets (12 mg or 24 mg). There are regimens in which tablets are taken every other day or twice a week. The dose is taken 20-30 minutes before a meal.

How long can you take Polyoxidonium?

Treatment regimens for the drug in tablet form include courses of continuous use lasting from 5 to 15 days. How much Polyoxidonium can be taken should be determined by the doctor who prescribes this medicine. If necessary, the course of treatment is repeated after three to four months, and the effectiveness of the application can be assessed using an immunogram.

Dosage forms and route of administration (dosage, frequency and duration of administration)

Polyoxidonium can be used without an immunogram. The grounds for prescribing a medication are clinical signs:

• colds more than six times a year;
• recurrence of herpes more than three times a year;
• frequent exacerbation of chronic inflammation;
• lack of effect from standard therapy.

When treated with the drug, hyperactivation of the immune system is impossible. It affects only low and high levels of immunity, without affecting those that are normal.

Rectal suppositories

Suppositories are available in dosages of 6 and 12 mg of the active substance. They are bullet-shaped and white or yellow-brown in color. Suppositories in the amount of 5 pieces are placed in a plastic package, in a cardboard box there are 2 blisters (10 suppositories).

Suppositories are the most convenient form of the drug for treating children. They can be used from six months of age, the dosage is calculated by the attending physician. The pediatric dose is considered to be 6 mg of the active substance, but 3 mg can be prescribed - in this case, the suppository must be divided into two parts. For children, the dosage can be calculated according to a simple scheme: 0.2 - 0.25 mg per 1 kg of child weight. The product is used rectally, the suppository is placed at night after bowel movements or a cleansing enema.

Typically, the treatment regimen looks like this: a suppository is administered once a day at the same time for 3 days, after which suppositories are placed every other day. The course of treatment is at least 10 suppositories. For patients suffering from chronic immune deficiency (including due to cancer), Polyoxidonium is prescribed as a maintenance medication twice a week for 2 to 12 months. For frequent colds, the medicine is used in courses of 10 suppositories 3 times a year.

The bullet-shaped form and oil in the composition make the administration of the suppository painless. In the rectum, the active substance is absorbed more actively than in the stomach, so the effect occurs faster.

Tablets for the prevention and treatment of RVI

The medication is available in the form of cylindrical, flattened tablets of white or yellowish color with orange inclusions. The dose of the active substance is 12 mg. Polyoxidonium in pill form is not recommended for use in children under 12 years of age. The dosage and duration of use for various diseases are as follows:

Type of disease	Number of tablets per day	Course duration (days)
Diseases of inflammatory origin in the oral cavity and pharynx	2	10–14
Viral, fungal, bacterial infections that are difficult to treat	3	15
Chronic otitis media and sinusitis	2	5–10
Chronic tonsillitis	3	10–15
Prevention of influenza and ARVI	2	10–15
Maintenance therapy for immunodeficiency, tuberculosis, cancer	2	up to 12 months

Depending on the child’s condition and the severity of the disease, the doctor can calculate the dosage of the medicine individually - approximately 100 mcg of the active substance is needed per 1 kg of body weight. The tablets, according to the instructions, should be taken half an hour before meals. They can be taken in two ways:

• orally, with plenty of water;
• sublingually, holding under the tongue until completely dissolved.

Lyophilisate for preparing a solution for injections and nasal drops

Lyophilisate is a dry substance that is intended for preparing a solution. Polyoxidonium is sold in glass ampoules containing white or yellow powder. There are 5 bottles in a cardboard box.

The lyophilisate is used for intramuscular and intravenous injections for adults and children over 12 years of age. The solution cannot be stored, so it is prepared immediately before use:

• For intramuscular injections, 1.5–2 ml of saline solution or distilled water is poured into the ampoule. To reduce pain during injection, the powder can be diluted in a similar proportion with novocaine or lidocaine. Typically, the dose of the drug for children is 6 mg of the active substance per day.
• For intravenous infusion, the contents of the bottle are diluted with four milliliters of hemodez and desktroza (2 ml of each substance). The solution is placed in a dropper, where 150–200 ml of saline solution is added to it.

The dosage and duration of use of the drug in injections are presented in the table:

Disease	Dosage	Treatment regimen
Acute inflammatory processes	0.1 mg per 1 kg of weight	the solution is administered every other day, 1 time per day, course – 5–7 injections
Chronic inflammatory diseases	0.15 mg per 1 kg of weight	the drug is injected every 3 days, the course of therapy is 10 injections
Complicated forms of allergic diseases	0.1 mg per 1 kg body weight intramuscularly	administration of the solution – every 1–2 days, course – 5 injections
Recurrent herpes	6 mg	1 time per day, course – 10 injections
Urogenital pathologies	6 mg	once every two days, 10 injections in total
Chemotherapy for cancer	6 – 12 mg	every other day, at least 10 times in total
Tuberculosis	6 – 12 mg	twice a week, course 10–20 injections

The drug is often used as nasal drops or used for instillation under the tongue of children. Nasal drops are especially effective for prevention as they stimulate local immunity.

The mucous membrane begins to actively produce class A immunoglobulin - these are antibodies that are the first to respond to pathogenic viruses and bacteria penetrating from the external environment.

To prepare a solution for nasal instillation or sublingual use, add 1 ml of boiled water or 9% sodium chloride to the ampoule with the drug. The medicine should be shaken thoroughly and then poured into a sterile syringe - this makes it more convenient to drop it into the nose or under the tongue. It can be stored in the refrigerator for a week. Before intranasal use, the substance should be warmed in your hands.

The solution is administered to children in both nasal passages, 1–3 drops, and the procedure is repeated every 3 hours. The duration of therapy depends on the disease:

• bacterial and fungal diseases, herpes infection – 10–15 days;
• chronic inflammatory processes in the nose and pharynx – 7–10 days;
• influenza or acute respiratory viral infection – 7 days.

Usually, improvement when using the drug occurs on the 4th day. It is recommended to adhere to the treatment period specified in the instructions in order to achieve a lasting effect. With repeated use, the effectiveness of the medication does not decrease. It does not cause allergies and has virtually no side effects.

Ingavirin or Polyoxidonium

The drug is produced in Russia and is not inferior in effectiveness to Polyoxidonium. The main substance of the drug is vitaglutam (pentanedioic acid imidazolylethanamide), auxiliary components: lactose monohydrate, silicon dioxide, magnesium stearate, potato starch.

Vitaglutam-based drugs no longer exist in neighboring countries. Polyoxidonium and Ingavirin are the only drugs of their kind with a pronounced antiviral effect, which has been confirmed by scientific research.

An antiviral effect is observed in relation to influenza A viruses, which include a variety of “swine” flu, Ingavirin is also active against influenza B viruses, adenovirus and rhinovirus infections, and parainfluenza.

The action of Ingavirin is based on the following mechanisms:

• the drug enhances the production of interferon by leukocytes to a physiological level;
• promotes the formation of cytotoxic lymphocytes;
• suppresses the production of active pro-inflammatory substances.

Thanks to these mechanisms, the severity of viral intoxication decreases in patients taking Ingavirin:

• weakness,
• headache,
• feverish conditions, rhinitis, pain in the nasopharynx.

The drug is available only in the form of capsules with a red shell of 30 mg and 90 mg. Contraindications include age under 18 years, pregnancy, lactation, since studies have not been conducted on children, pregnant and lactating women.

On a note! Despite the age limit, Ingavirin, along with Polyoxidonium, remains the most popular antiviral drug among the population.

Analogues of the drug Polyoxidonium

Analogues of the drug by mechanism of action:

1. Broncho-Vaxom.
2. Affinoleukin.
3. Arpeflu.
4. Neuroferon.
5. Actinolysate.
6. Florexil.
7. Glutaxim.
8. Wilosen.
9. Anaferon.
10. Ribomunyl.
11. Engystol.
12. Immunofan.
13. Immunal.
14. Ismigen.
15. Cycloferon.
16. Taktivin.
17. Gerbion.
18. Cytovir-3.
19. Gepon.
20. Bioaron.
21. Polymuramyl.
22. Bestin.
23. Isophone.
24. Arpetolide.

What the manufacturer says about the drug

Produced for injection by injection, “Polyoxidonium” is a drug manufactured using azoximer bromide, which does not have a polyclonal effect. Tests did not reveal the presence of mitogenic, antigenic effects. It is believed that Polyoxidonium does not provoke allergies and cannot cause mutations. The substance is considered non-toxic for the gestating fetus, embryo. It does not have the qualities of a carcinogen or teratogen.

The active component that ensures the effectiveness of the medicine does not smell or taste. It does not have an irritating effect when used topically, so applying the medication to the mucous membranes of the ENT organs and ophthalmological system is completely safe and does not cause discomfort.

Pharmacodynamics and pharmacokinetics

Polyoxidonium (or azoximer bromide) helps increase the body's resistance to infections caused by viruses, bacteria or fungi.

The mechanism of its action is associated with the substance’s ability to influence phagocytic cells and NK cells (natural or natural killer cells), as well as stimulate the process of antibody formation.

The drug helps restore the immune status in secondary immunodeficiency conditions, which are caused by various types of infections, injuries, burns, malignant tumors, complications after surgical interventions, treatment with chemotherapy drugs, including cytostatic agents and steroid hormones.

Along with the immunocorrective effect of azoximer, bromide also has a pronounced detoxifying effect, which is due to the structure and high-molecular nature of this substance.

The result of its effect on the body is an increase in the resistance of cell membranes to the cytotoxic (causing damage to cells up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

Prescribing Polyoxidonium in combination with other drugs significantly increases the effectiveness of therapy, shortens its duration, allows you to reduce doses or completely avoid the use of antibiotics, bronchodilators and glucocorticosteroids, and helps to increase the period of remission (that is, the period of weakening or complete disappearance of the symptoms of the disease).

Polyoxidonium is well tolerated by patients, does not exhibit mitogenic or polyclonal activity, does not have antigenic properties, does not provoke the development of allergies, mutations and other defects in fetal development, does not have a teratogenic effect on the developing fetus, and has no carcinogenic or embryotoxic properties.

Azoximer bromide is characterized by a high bioavailability, which is about 89 percent. When administered intramuscularly, Cmax in blood plasma is observed 40 minutes after injection.

The substance is distributed fairly quickly in tissues. In the body, azoximer bromide is biotransformed. Its elimination is carried out mainly by the kidneys.

Indications for use

Pills

Prescribed for infectious and inflammatory diseases (fungal, bacterial and viral origin) that cannot be treated with standard methods, in adolescents over 12 years of age and adults, both in remission and in the acute stage.

As part of complex therapy, it is used for diseases such as:

• infectious and inflammatory diseases of the inner and middle ear, oropharynx, upper respiratory tract, paranasal sinuses;
• for allergic pathologies complicated by recurrent viral, fungal and bacterial infections (including bronchial asthma, hay fever).

The drug is used for the rehabilitation of long-term and frequently (more than 4-5 times a year) ill patients.

As monotherapy, it is prescribed for the purpose of: preventing recurrent herpetic infections and exacerbations of chronic foci of infections of the paranasal sinuses, oropharynx, inner and middle ear, and upper respiratory tract. The drug is also indicated for immunocompromised individuals for the correction of secondary immunodeficiencies that develop as a result of exposure to adverse factors or aging, and for the prevention of acute respiratory viral infections and influenza in the pre-epidemic period.

Suppositories

Suppositories are used as part of complex therapy to correct immune deficiency in children over 6 years of age and adults:

• for acute fungal, bacterial and viral infections;
• for chronic recurrent infectious diseases that are not amenable to standard treatment, both in the stage of remission and in the stage of exacerbation;
• for inflammatory pathologies of the urogenital tract, including cystitis, urethritis, prostatitis, pyelonephritis, endomyometritis, salpingo-oophoritis, cervicosis, cervicitis, colpitis, bacterial vaginosis (including viral origin).

Also, indications for use are various forms of tuberculosis, rheumatoid arthritis (complicated by acute respiratory viral infections, acute respiratory infections or long-term treatment with immunosuppressants), allergic diseases complicated by viral, fungal and bacterial infections (including atopic dermatitis, bronchial asthma, hay fever), activation of regenerative processes (including trophic ulcers, burns, fractures), rehabilitation of long-term and frequent (4-5 times a year) ill persons, reduction of both hepato- and nephrotoxic effects of drugs, the period after radiation and chemotherapy of tumors.

As monotherapy, it is prescribed for the purpose of: prevention of recurrent herpetic infections, exacerbations of chronic foci of infections, for the correction of secondary immunodeficiencies that appear due to the influence of adverse factors or aging, for the prevention of acute respiratory infections and influenza in the pre-epidemic period.

Instructions for using Polyoxidonium

The drug is distributed freely, but it is recommended to treat infectious and immunological pathologies with this drug after undergoing a medical examination. The specialist will assess the severity of the patient’s condition and select a drug therapy regimen. Typically, azoximer bromide is used as an adjuvant. If a bacterial infection is present, the patient may require antibiotics. Compliance with the rules for using Polyoxidonium reduces the risk of complications.

Methods of administration

• The tablets should be swallowed and washed down with a small amount of water. It is recommended to take the product 30 minutes before eating.
• Rectal suppositories are inserted into the anus. The drug is gradually absorbed.
• The dry substance (lyophilisate) is dissolved in water or saline. After stirring, you need to wait 2-3 minutes. The solution is used for intramuscular or intravenous injections.

The choice of method of drug administration depends on the purpose of treatment. Resorption of the tablet in the oral cavity is suitable for the treatment of inflammatory diseases of the upper respiratory tract. Oral administration is used to treat systemic infections and immune pathologies. The injection form is used if the drug is poorly absorbed by other means.

Dosage regimens

• Drug therapy for acute respiratory infection: 1 tablet twice a day for a week.
• Treatment of infectious and inflammatory diseases of the upper respiratory tract: 1 tablet twice a day for 7-10 days.
• Treatment of complicated immunological pathologies, such as bronchial asthma. Take 1 tablet twice a day for 7-10 days.
• Prevention of the development of ARVI during the cold season: 1 tablet every day for 10 days.
• Prevention of relapse of herpes: 1 tablet twice a day for 10 days.
• Reducing the risk of exacerbation of infectious processes: 1 tablet every day for 10 days.
• Prevention of immunodeficiency due to chronic stress: 1 tablet daily for 10 days.

Important! Treatment of children aged 3 to 10 years requires reducing the daily dosage by half.

If a child requires medication, it is recommended to first consult a pediatrician. It is possible to prescribe an individual treatment regimen, including the use of other medications.

additional information

• Azoximer bromide does not interact with other medications. You can use this remedy together with antibiotics, anti-inflammatory drugs and other medications as prescribed by your doctor.
• An allergic reaction is possible, manifested by redness of the integumentary tissue, skin rashes and other characteristic symptoms. If you have an allergy, you should stop taking the medication and consult your doctor.
• Missing a daily dose is not a reason to increase the dosage the next day. The patient should continue to follow the treatment regimen.
• The drug does not affect the speed of psychomotor reactions. You can drive a car during treatment.

It is recommended to check with your physician for the use of injections and rectal suppositories.

Polyoxidonium or Viferon

Viferon is another analogue, the main active ingredient of which is recombined interferon. Available in the form of gel, ointment and suppositories.

Indications

The drug is used locally to eliminate the following problems:

• prevention of ARVI;
• flu treatment;
• herpes;
• pneumonia.

To prevent viral diseases, it is recommended to lubricate children’s noses before going to school or kindergarten.

Side effect

Such symptoms are rare, but an allergic rash and itching are possible. Usually the problems disappear after stopping use.

About the medicine

Children's Polyoxidonium is an immunostimulating drug.

The medicine is available in:

• candlelight;
• tablets;
• solution.

The liquid form is used for intravenous administration, used as drops in the nose. Thanks to the different forms of release, the medication is easily used in children of different ages. The active ingredient of the drug is azoximer bromide, the content of which differs in different dosage forms.

The content of azoximer bromide in suppositories is 6 mg. Suppositories have a conical shape, yellowish in color with a specific odor of cocoa. The drug is available without a prescription. Suppositories are packaged in paper packages of 10 pieces, and instructions for use are also included. Polyoxidonium suppositories are prescribed to children from the age of six.

The tablets contain 12 mg of the active drug. They are cylindrical, flat, and light yellow to orange in color. They have a notch and are not uniform in color because they have darker dots. Tablets are packed in 10 pieces per pack along with instructions. The medicine is sold without a prescription.

There is a third form of drug release - lyophilisate. This is a powdery substance intended for preparing a solution. The product is available in bottles containing 6 mg of polyoxidonium.

Method of drug administration:

• intramuscularly with saline;
• intravenous drip;
• in the form of nasal drops.

The drug is packaged in clear glass bottles of 6 mg. The package contains 5 bottles and instructions. Available in pharmacies only with a prescription.

Composition and release form of Polyoxidonium drops

The drug is sold in three dosage forms:

• tablet form for oral use;
• suppositories for vaginal and rectal use;
• powder form (lyophilisate) for intramuscular injection, and also most often for use under the tongue and in the nasal passages.

The lyophilisate for the preparation of drops looks like a hygroscopic and photosensitive porous substance from yellow to white with a yellow color.

As in other forms of the drug, the active ingredient in drops is azoximer bromide, with a dosage of 3 mg or 6 mg per bottle. It is this substance that is a highly effective immune modulator, thanks to which the body increases its ability to resist bacterial acting organisms at a young age.

Auxiliary components are povidone, betacarotene, mannitol.

The lyophilisate is produced in bottles of 3 mg or 6 mg.

Action of the medicine

Polyoxidonium is a polymer that activates the protective functions of the child’s body. If Polyoxidonium is dripped into a child’s nose, the nasopharyngeal mucosa begins to intensively produce immunoglobulin. These are antibodies that actively fight viruses and other virulent microorganisms that enter the child’s respiratory tract. In this way, the process of spreading infection throughout the body is inhibited . In addition to the immunostimulating effect, Polyoxidonium has an antitoxic effect, that is, it blocks the reproduction of viruses and removes them.

Polyoxidonium helps restore tissue cells damaged during illness , since it acts as an antioxidant and activates metabolic processes at the cellular level. At the same time, the child’s general immunity increases and his well-being improves. The medicine makes the body work and activates its self-defense. The use of Polyoxidonium in combination with other medications increases their therapeutic effect.

After oral administration, the medicine is quickly absorbed by the gastrointestinal tract and begins to act after 35-45 minutes. The drug is highly bioavailable, so after administration it reaches all tissues of the body within 40 minutes. The drug is excreted primarily in the urine.

When is it prescribed?

Indicated for use in children over 6 months of age together with other drugs for:

• recurring infectious diseases;
• treatment of acute and protracted pathologies, stimulated; bacterial, fungal, and viral infections;
• emergency manifestations of allergies: eczema, asthma, hay fever, atopic dermatitis;
• tuberculosis;
• oncology (during chemotherapy and radiation therapy and after it, in order to reduce the immunosuppressive, hepato- and nephrotoxic effects of drugs);
• rehabilitation for frequent and long-term illnesses.

Mode of application

Polyoxidonium injections can be administered deep into muscle tissue, or into a vein by drip, or the intranasal method is also acceptable.

If it is necessary to treat an acute stage of inflammatory disease, then the drug is administered every day for three days, the dosage is 6 milligrams of the drug. Subsequent procedures are performed with a break of one day. On average, the duration of treatment is 5-10 days.

In the treatment of chronic inflammatory processes, as well as for rheumatoid arthritis, treatment for the first 5 days involves administering the drug twice a day, every other day. Follow-up therapy consists of two injections every 7 days. The daily or single dosage should not exceed six milligrams of the drug. The duration of therapy is at least 10 injections according to the given scheme.

If tuberculosis is detected, patients are prescribed the drug twice a week in a volume of 6 milligrams per procedure. The duration of therapy is 10-20 injections.

To eliminate urogenital diseases, injections are given at intervals of one day. A total of about 10 injections at a dosage of six milligrams will be required. Additionally, antibiotics and uroseptics are introduced into the complex.

Similar treatment tactics are also practiced in patients who suffer from chronic herpes. For more effective treatment, Polyoxidonium is combined with stimulants for the production of endogenous interferon, as well as drugs against viruses, and Interferon preparations.

If you need to get rid of allergic diseases, it is recommended to take five injections of the drug in a volume of 6 milligrams. The first two injections are given every day, then therapy is continued every other day.

If there are allergies or toxic-allergic lesions, it is necessary to administer the drug by drip into a vein. The dosage, depending on the patient’s condition, ranges from 6 to 12 milligrams. Therapy is supplemented with antiallergic drugs and Clemastine.

For patients who have recently completed a course of chemotherapy treatment or are undergoing it, Polyoxidonium is prescribed in a dosage of 6-12 milligrams to reduce adverse reactions. To achieve the optimal effect, 10 injections are indicated, with an interval of one day.

If it is necessary to correct the state of immunodeficiency that occurs after undergoing radiation or chemotherapy, as well as after removal of tumor formations by surgery, patients are advised to administer 6 milligrams of the drug 1-2 times every 7 days. The duration of therapy is long, ranging from 2-3 months to one year.

As indicated in the instructions for use of the drug, patients with a history of renal failure are allowed to administer Polyoxidonium no more than twice a week.

To prepare an injection solution that will be injected deep into the muscle tissue of patients, the contents of one bottle in a volume of 6 milligrams should be dissolved with two milliliters of saline or water for injection.

If there is an indication to inject Polyoxidonium intravenously, then it is necessary to mix the contents of one ampoule with three milliliters of saline solution, hemodez, plasma replacement drug rheopolyglucin or 5% glucose.

After this, the solution, being sure to observe sterility conditions, is transferred to a bottle with one of the indicated products, with a volume of 0.2-0.4 liters. The prepared parenteral solution is used immediately after mixing. It is strictly forbidden to store it.

If a patient is diagnosed with acute or chronic ENT diseases, when it is necessary to speed up the process of restoring damaged mucous membranes, as well as to prevent the likelihood of complications or relapses, Polyoxidonium is administered intranasally for the prevention of influenza and acute respiratory infections.

You can prepare a solution of this type using 6 milligrams of lyophilisate mixed with twenty drops of one of the presented substances: saline solution or boiled water. It is important to observe the temperature regime, in which the liquid should be at room temperature.

The prepared solution should be injected into each nasal passage at least three times a day. The interval between instillations is from two to three hours. You need to administer 1 to 3 drops at a time. The duration of therapy is 5-10 days.

After the solution has been prepared, it can be stored without loss of therapeutic effect for one day. After the expiration of time, the product must not be used.

In pediatrics

In most cases, patients in the pediatric age group are prescribed Polyoxidonium in the form of tablets or suppositories; injections are prescribed much less frequently. If there was an appointment, then for injection it is necessary to use the drug in a dosage of 3 milligrams.

To prepare the solution, you need to mix the contents of the ampoule with one milliliter of saline solution or distilled water. If it is necessary to administer the drug intravenously (drip), the contents of the bottle are mixed with one of the substances: Hemodez-N, saline solution or Reopoliglucin in a volume of two milliliters. After this, the prepared mixture must be shaken thoroughly and then added to the dropper, the volume of which is 150 milliliters.

Polyoxidonium can be prescribed by pediatricians to children aged six months and older. The daily dosage calculation is based on the child's weight. The instructions indicate that per kilogram of body weight there should be no more than 100-150 micrograms of the drug.

Each bottle, the volume of which is equal to three milligrams, contains three micrograms of the product, which is important to consider before the injection. It is also worth knowing that the Polyoxidonium injections themselves are quite painful. The drug is administered intramuscularly to children as slowly as possible.

If the child is not allergic to novocaine, then it is added to the ampoule in a volume of 1 milliliter (concentration 0.25%). If the patient has an acute inflammatory disease, then the procedures are indicated at intervals of one day. The duration of therapy is from 5 to 7 injections. When chronic infections worsen, injections are given twice a week (a total of 10 procedures are indicated). If there is an acute allergic condition, then the medicine is administered by drip into a vein, and it is supplemented with antihistamines.

In gynecology

Polyoxidonium can be used to treat gynecological diseases of an inflammatory nature. Most often it is included in complex therapy when a woman is diagnosed with the following pathologies: pelvic peritonitis, salpingitis, oophoritis. Most often, such conditions do not have pronounced symptoms and are chronic.

It often happens that the use of antibacterial agents does not provide the necessary therapeutic effect. This reaction of the body is due to a decrease in the sensitivity of the infectious agent to prescribed medications.

Against the background of such conditions, patients usually begin to develop immunodeficiency, and the long-term presence of the pathogen in the body provokes constant relapses or the development of complications. Considering all the described conditions, it is very important to include an immunomodulator such as Polyoxidonium in the treatment complex.

Thanks to medical research, it was found that the use of the drug promotes:

• Normalization of menstrual, secretory and reproductive functions;
• A significant reduction in the number of infectious agents already from the second day of therapy;
• Improvement of indications for;
• Reducing the duration of treatment by an average of a week;
• Reducing the previously prescribed dosage of antibiotics to the minimum that provides a therapeutic effect;
• Eliminating the likelihood of complications or relapses.

After a woman undergoes a course of treatment, during a control study, indicators of previously identified inflammatory processes are no longer detected. , the symptoms of the disease completely disappear. It is also noted that after six months of treatment for inflammatory pathologies of the pelvic organs, relapses practically do not occur.

The duration of therapy and the form of the drug are prescribed by the attending physician, based on the patient’s condition, as well as the established diagnosis.

Pharmacological properties

The drug Polyoxidonium in injection form is a medication that effectively eliminates secondary immunodeficiency in the body. It is thanks to this action that the drug is indicated for the treatment of diseases that have a chronic or recurrent course.

Polyoxidonium is almost always part of complex therapy. This drug helps restore the ability to regenerate.

Injections are indicated for patients in the postoperative period, especially with the development of complications.

A special feature of Polyoxidonium is its ability to reduce the toxicity of other medications, as well as other substances of chemical origin. Thanks to this, the body's cells become more resistant to aggressive influences and their membranes are not destroyed.

If the drug is prescribed as part of complex therapy, then positive dynamics occur earlier. The duration of treatment is significantly reduced. When taking Polyoxidonium, patients reduce the dose of antibiotics, glucocorticosteroids, antispasmodics or even cancel them completely. The period of remission for chronic diseases increases.

The drug is well tolerated by the body not only in adults, but also in children. The DNA structure remains unchanged, and allergic reactions do not develop. The likelihood of cancer does not increase. As for pregnant women, they can take the drug, but only after consultation with their gynecologist. Polyoxidonium does not have a negative effect on the fetus; therefore, it is not the cause of mutation or abnormal development.

The bioavailability of azoximer bromide is quite high and corresponds to 89%. If the drug is administered into the body intramuscularly, then after 40 minutes its maximum concentration can be observed in the blood plasma. The substance is distributed and biotransformed in tissues quickly. Excretion is carried out by the kidneys.

pharmachologic effect

Immunomodulatory drug. Increases the body's resistance to local and generalized infections. The basis of the mechanism of immunomodulatory action of Polyoxidonium is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation.

Restores immune responses in secondary immunodeficiency conditions caused by various infections, injuries, burns, malignant neoplasms, complications after surgery, the use of chemotherapeutic agents, incl. cytostatics, steroid hormones.

Along with the immunomodulatory effect, Polyoxidonium has pronounced detoxifying activity. Increases the resistance of cell membranes to the cytotoxic effects of drugs and chemicals, reduces their toxicity. These properties of the drug are determined by the structure and high-molecular nature of the drug.

The use of Polyoxidonium as part of complex therapy for cancer patients reduces intoxication during chemotherapy and radiation therapy, allows treatment without changing the standard therapy regimen due to the development of side effects (including cytopenia, vomiting, diarrhea, cystitis, colitis).

The use of Polyoxidonium can increase the efficiency and shorten the duration of treatment, significantly reduce the need for antibiotics, bronchodilators, corticosteroids, and increase the period of remission.

The drug does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Also find out what types of tablets for the papilloma virus are available and whether they are effective.

Why is the drug prescribed?

Polyoxidonium lyophilisate is prescribed after diagnosing diseases and pathological processes such as:

• benign neoplasms of viral etiology (warts, papillomas);
• allergic dermatitis;
• chronic infectious and inflammatory diseases;
• rheumatoid arthritis;
• intestinal dysbiosis;
• bronchial asthma;
• oncology;
• tuberculosis;
• radiation dermatitis;
• fractures, ulcers or burns.

Important!

The drug is recommended for use for the prevention of postoperative infectious complications, activation of regenerative processes, prevention of influenza and acute respiratory infections.

Lyophilization devices

We have developed special devices to produce lyophilisate. Instructions for using such devices require special technical knowledge and skills. The systems for lyophilization of the French production “Usifroy”, the German “Hohvakumm”, the English “Edward”, and the American “Stoke” have proven themselves. In Russia, the most common device is the Czech-made Frigera.

Operating principle

The main benefits and principle of action of Polyoxidonium are:

• activation of the human immune system;
• reducing the body's sensitivity to infectious pathogens;
• providing a detoxifying effect, absorbing a dangerous pathogen and removing it from the body;
• accelerating the regeneration of damaged tissues.

In addition, the drug increases the resistance of cell membranes to the action of chemicals on them, that is, it reduces their toxicity.

How to use (dosage, course of treatment)

The dosage regimen for children over 6 years of age is as follows: a suppository is used at a dose of 6 mg, one suppository per day.

In the next 10-20 days, the medicine is used every other day . During the period of autumn and winter prevention, the course is carried out one suppository every other day.

The general course is 10 days. If necessary, the described course of treatment is repeated after 3-4 months. Depending on the diagnosis made by the doctor, you can take it once a day, every other day or twice a week.

For tuberculosis, the drug is administered according to the standard regimen for fifteen days. If there is a need to maintain the result, then suppositories are additionally used twice a week.

For acute infectious processes, ulcers and burns, use 1 suppository for 10-15 days.

For chronic inflammation, administration is carried out according to the standard regimen . After the onset of remission, the course is repeated, one suppository every 1-2 days.

For seasonal prevention of viral diseases, one suppository is administered for ten days. To prevent acute respiratory infections, it is taken according to the standard prescription.

Forms of release and dosage of the drug

Polyoxidonium is a modern immunostimulant. It improves the functioning of the immune system, reduces the risk of developing viral, fungal and bacterial diseases. The main component is azoximer bromide, its dosage depends on the form of the drug.

Release form:

1. Tablets are pale yellow, pale orange in color with a dividing strip on one of the surfaces. The amount of the main substance is 12 mg. The tablets are packaged in blisters of 10 pieces, the average price is 790-820 rubles.
2. Rectal-vaginal suppositories are pale yellow in color with a distinct cocoa odor, contain 6 or 12 mg of the main ingredient, packaged in blisters of 10 suppositories. The average cost is 900-950 rubles.
3. Lyophilisate is a powder for the preparation of injection solutions for local use, containing 3 or 6 mg of the main substance. The medicine is packaged in glass containers, the package contains 5 units of the drug, the average price is 760-1100 rubles.

Important! Polyoxidonium is effective not only for immunity. The drug quickly eliminates the manifestations of intoxication due to poisoning with drugs and chemicals.

Nasal use of the drug in adults

Diluted Polyoxidonium lyophilisate can be used nasally in the form of drops. This method allows you to act directly on the area of ​​the inflammatory process, increasing cellular immunity. If the doctor prescribes Polyoxidonium instillation into the nose, you need to buy the lyophilisate of the specified dosage.

When is it accepted?

Nasal use is necessary when an inflammatory process has been occurring in the nose for a long period, especially if other medications do not help.

Indications for use:

1. Treatment and prevention of rhinitis - drops increase local immunity and prevent pathogenic microorganisms from growing and multiplying in the tissues of the nose. In case of illness, the drug promotes a speedy recovery and prevents the development of complications.

2. Radiation and chemotherapy - after such treatment, the body becomes more susceptible to viral and bacterial infections, therefore Polyoxidonium is prescribed to prevent the development of diseases of the upper respiratory tract.

3. Nasal polyposis - the drug is needed to prevent further tissue growth, relieve the inflammatory process and prevent infection.
4. Atrophic rhinitis - the solution helps to moisturize the nasal mucosa and accelerate the secretion of immunoglobulins, which helps normalize the condition of the affected tissues and prevent infection.
5. Chronic sinusitis – Polyoxidonium helps eliminate the source of infection and prevent exacerbation. In most cases, the drug not only prolongs the period of remission, but also completely leads to recovery.
6. Allergies - the use of Polyoxidonium helps remove foreign agents and their toxins, relieve swelling and inflammation.
7. Preparation before operations in the nasopharynx and prevention of complications after surgery.

The drug can be used nasally for other diseases, but this use best helps to cope with the source of inflammation at the local level.

When administered nasally, the production of immunoglobulin A improves, which most quickly responds to the penetration of foreign microorganisms into the nasal cavity. This helps local immunity to work in full force and prevent the growth and reproduction of viruses, bacteria and fungi.

Dosage

But even if pathogenic microorganisms have overcome cellular defenses, humoral immunity begins to fight against them, which Polyoxidonium can also affect. The drug has high bioavailability and is very quickly distributed throughout all tissues. It is able to penetrate the blood and the maximum concentration in plasma is detected 30-40 minutes after use. It is excreted from the body by the kidneys after 1.5 days.

Humoral immunity

For nasal use in adult patients, lyophilisate is prescribed at a dosage of 6 mg. It is diluted with 1 ml of saline, distilled or boiled water at room temperature. You need to drip the drug three times a day into each nasal passage, 3 drops, for 10 days. The prepared solution can be stored in the refrigerator for no more than 1 week, but for better results it is recommended to use a freshly prepared solution.

Maria writes: “An excellent product, we use it with the whole family. After just 1-2 days of use, the symptoms of the disease are eliminated, headaches go away, chills and the nose begins to breathe.”

Efficiency

Polyoxidonium is the latest development, which has recently been introduced to the pharmaceutical market. Thanks to it, you can quickly cope with infectious diseases of various etiologies: viral, bacterial, fungal. Symptoms begin to disappear fairly quickly.

The main effects of the drug are relieving inflammation, removing toxins, increasing the body's defenses and resistance. The main active ingredient here is azoximer bromide.

Nowadays, pharmacies offer a wide range of immunomodulatory drugs, but Polyoxidonium has a number of significant advantages. Let's take a closer look at them.

Rapid onset of therapeutic effect. A person begins to feel the effect stated in the instructions several hours after the injection of the product. This effectiveness is due to the unique structure of the product. The drug molecule consists of certain active groups, the activity of which is aimed at absorbing pathogenic microparticles, while it is quickly eliminated from the patient’s body.

The drug is a safe medicine due to the fact that it does not contain dangerous or potentially dangerous antigens, as well as substances of plant origin, against which people may develop allergic reactions.

Polyoxidonium is also distinguished by its versatility. It can be prescribed for various diseases and pathological conditions that provoke depression of the immune system in the body.

A wide range of dosage forms is another advantage of the drug over other drugs. The medication is available in the form of injections, tablets, and suppositories. Thanks to this, each patient will be able to choose the best option for himself.

It is worth noting that the effectiveness and safety of the drug was tested in Russia and is not recognized by the global medical community.

Side effects and contraindications

The experiments carried out showed the rarity of adverse reactions.
However, its complete absence cannot be denied. Therefore, itching and swelling may occur. Any drug has special restrictions; in this situation the drug is contraindicated:

• pregnant women;
• persons suffering from renal failure;
• with individual intolerance;
• lactation period;
• children under 6 years old.

People with kidney problems should use the tablets with caution.

Polyoxidonium for children

In tablets, the drug is used in therapy to treat children over 3 years of age, in the form of a solution - from 6 months, in suppositories 6 mg rectally only - from 6 years. The duration of treatment and rules of administration for a child are identical to the treatment of adult patients, only the dosage differs.

Dosages for children:

• tablets - 6 mg twice a day for children aged 3-10 years; after 10 years, adult dosages of the drug are prescribed;
• intravenously, intramuscularly – 0.1 mg/kg in a course of 10 injections;
• drops under the tongue or in the nose – 1 drop/kg, but not more than 40 drops, divide the dose into 2-3 doses;
• 1 suppository every 24 hours after bowel cleansing.

Important! How often can Polyoxidonium be used? If necessary, therapeutic or preventive courses can be carried out with a break of 3-4 months. For cancer patients and patients with positive HIV status, the doctor may prescribe long-term maintenance therapy for 2-12 months. The medicine is taken 1-2 times a week.

Application of bacterial lysates

Bacterial lysates dried by lyophilization are used as immunostimulants. The mechanism of action is similar to the effect of a vaccine. Once in the body, the virus causes a response from the human immune system, producing protective antibodies. Thus, if a person is further infected with a pathogenic microorganism, the immune system will respond very differently than during the initial infection. The presence in the body of protective antibodies, which were developed as a result of the fact that a person took a lyophilisate of bacteria for preventive purposes, will significantly reduce the likelihood of infection or a severe course of the disease. Most often, these drugs are used to prevent respiratory viral diseases.

Analogs and price

The drug Polyoxidonium has no structural analogues for the active substance. But at the same time, it is possible to distinguish medications that have a similar effect and therapeutic effect, but have a different composition and active component:

• Actinolysate;
• Gepon;
• Glutoxim;
• Deoxynate;
• Imunorik s;
• Imunofan;
• Molixan;
• Copaxone-Teva;
• Affinoleukin;
• Wilosen;
• Zadaxin;
• Imuron-vac;
• Uro-BZ medak;
• Stimforte;
• Timalin;
• Cycloferon.

Price of ampoules 6 mg - from 950 rubles

Instructions for using injections, how to dilute the solution, how to inject intramuscularly?

The drug must be used strictly according to the instructions, which indicate the exact dosages for adults and small patients.

For adults (ampoules, 6 mg)

For intramuscular administration, dissolve the lyophilisate (6 mg) in 2 ml of 0.9% sodium chloride solution or distilled water, then leave the mixture for 2-3 minutes and mix with rotational movements. There is no need to shake the solution.

Important!

The duration of the course of treatment, the location of injections and the number of injections are determined by the doctor and depend on the established diagnosis, the severity of the disease, as well as the individual characteristics of the patient’s body.

For children

To prepare a medicinal solution, dissolve 3 mg of powder in 1 ml of distilled water or sodium chloride. Leave the mixture for a few minutes and mix thoroughly.

During pregnancy and lactation

No teratogenic or embryotoxic effects of the drug were detected during the experiments, however, the instructions indicate that it is not advisable for pregnant and lactating women to use the drug.