Jess for endometriosis: effective or not?

When choosing a method of treating endometriosis in women with drugs, the doctor is faced with a difficult task - how to stop the disease without causing harm. The reason for this predicament is that endometriosis is a mysterious disease, many issues of etiology and pathogenesis of which are unclear.

• 5 Non-hormonal drugs 5.1 Anti-inflammatory drugs (NSAIDs)
• 5.2 Antibacterial drugs

What is endometriosis?

Endometriosis is a purely female disease that can occur in the uterus and ovaries. Associated with excessive growth of the endometrium lining the surface of the uterus. This is a special layer that helps the egg to latch onto during fertilization. Usually, after the egg is firmly anchored in the endometrium, the formation of vessels responsible for the development of the fetus occurs. If the pregnancy is interrupted, the layer of the uterine mucosa peels off and comes out along with the blood. A woman is about to menstruate.

There are two types of endometriosis:

• Endometriosis genital. This pathology affects the uterus and its cervix, vagina, and ovaries. This type of disease can be found in 85% of cases.
• Extra-genital endometriosis. With this type of disease, damage occurs to internal organs, the bladder, intestines and postoperative scars. This is a rare form of the disease. Occurs due to blood clots entering the abdominal cavity. This type of pathology is treated surgically.

Endometriosis provokes inflammation in the peritoneum. Disturbs the functioning of internal organs. It affects the walls of the uterus. Causes the formation of adhesions and nodes. This disease causes infertility.

The most common causes of this disease include:

• hormonal disorders;
• immune failures;
• heredity;
• stress;
• various neuropsychological disorders.

Symptoms of the disease do not appear immediately, but only at a late stage of development:

• The uterus increases in size until six weeks of pregnancy. Takes on a round shape.
• Heaviness appears in the lower abdomen.
• I am worried about pain in the abdomen. They are felt both during menstruation and during urination, defecation, and also during sexual intercourse.
• Infertility occurs.
• The menstrual cycle is disrupted.

The disease progresses differently in all women. An experienced gynecologist, based on the test results, will easily make an accurate diagnosis and prescribe appropriate treatment, prescribe a medicine for endometriosis, which will prevent relapses.

Methods of treating pathology

What medications are used to treat endometriosis? This question is difficult to answer. Most doctors agree that the treatment of pathology should be comprehensive. It is not just one individual organ that should be treated, but the entire body as a whole.

Before prescribing a medicine for endometriosis, the doctor takes into account the advanced state of the disease, the patient’s immunity, the characteristics of the disease, complications, localization and spread of the process.

Endometriosis is treated in three main ways:

• combination therapy;
• surgical intervention;
• conservative method of treatment.

Endometriosis can be cured without surgery only in rare cases. Conservative therapy is used only when:

• infertility;
• asymptomatic course of the disease;
• women's reproductive age;
• adenomyosis.

In all other cases, gynecologists recommend surgical treatment. Depending on the severity of the disease, the uterus will be preserved or completely removed.

With the conservative-surgical method, damaged areas are surgically removed, and non-pigmented, hard-to-reach and microscopic lesions are treated with medication. After treatment for endometriosis, patients successfully become pregnant, carry a child to term, and give birth.

Medicines used in the treatment of pathology

The gynecologist selects a medicine for endometriosis based on the severity of the disease. The drugs used are:

• to reduce the production of sex hormones;
• from uterine bleeding;
• to eliminate pain symptoms and other negative manifestations;
• before surgery;
• during the rehabilitation period, after surgery.

Medicines for endometriosis should be taken only according to the regimen prescribed by a doctor. You should strictly adhere to the recommended course duration, since many medications, with longer use, can cause many side effects.

What medications are used to treat endometriosis? This question is often asked by women who have discovered this pathology. As a rule, several groups of drugs are used in the treatment of this disease, these are:

• Gonadotropin-releasing hormone agonists. The medications are hormonal. Reduce the amount of estrogen production. Can be used both in tablet form and as injections. The body is put into artificial menopause. Menstruation stops coming due to lack of estrogen. Against this background, the endometrium also stops growing. The lesions regress. Such drugs should be treated for about six months. Longer therapy can lead the body to early menopause. The best drugs for endometriosis in this group are the drugs Zoladex, Diferelin, Buserelin.
• Antigestagens, inhibitors of gonadotropic hormone production. Drugs in this category inhibit the production of luteinizing and follicle-stimulating hormones. Suppress progesterone production. The drugs are available in the form of tablets and capsules. Medicines have significant side effects. The most popular medications are Mifepristone and Danazol.
• Gestagens. Another group of medications used in the treatment of endometriosis. Progesterone tablets stabilize the menstrual cycle, lengthening the second phase. The most effective drugs in this category include Norkolut, Duphaston, and Utrozhestan. Medicines can be prescribed not only in the form of tablets, but also in the form of injections.
• Combined oral contraceptives. They contain estrogens and gestagens. Stimulates the production of female sex hormones. Stabilize development and prevent endometrial growth. Drugs in this category are taken for about six months. Popular: “Janine”, “Klaira”, “Diane-35”, “Jess” and “Yarina”.

Intrauterine devices can be used to treat the disease. The most popular is Mirena. Sometimes medications containing male hormones and androgens are used. One of these drugs is Methyltestosterone. In addition to these medications, non-hormonal medications can also be used in the treatment of endometriosis.

Treatment of endometriosis is complex and long-term, at least six months. To achieve a good result, you must follow all doctor's instructions. Do not violate the treatment regimen. The disease is very serious and can progress, so self-medication in this situation should be excluded.

Hormonal treatment of endometriosis

The role of hormonal treatment for endometriosis is enormous; it is quite effective and is used after surgery to prevent the appearance of new lesions. When treating endometriosis with hormonal drugs, two strategies are used: temporarily “turning off” all ovarian functions, or exposing the lesion to progestogens.

Birth control pills

Combined oral contraceptives or COCs for endometriosis are prescribed by gynecologists primarily for women who want to exclude pregnancy and at the same time relieve pain from this disease. The positive aspects of treating endometriosis with birth control pills are as follows: COCs are relatively inexpensive and have few side effects, so it is possible to take them for a long time.

They fight pain during menstruation quite well.

The disadvantages of treating endometriosis with birth control pills are:

• Despite their widespread use, there is not enough research to confirm their effectiveness and safety.
• If a relapse of the disease occurs, it is useless to take contraceptives.
• The influence of the estrogenic component of COCs on the development of the disease has been poorly studied; it is quite possible that it stimulates the growth of endometroid formations.
• They do not reduce chronic pelvic pain or pain during intercourse.
• An ethical question - today, almost no COC drug can guarantee complete suppression of ovulation, so conception may still occur, but the embryo will not be able to attach to the walls of the uterus.

Janine

Janine contains ethinyl estradiol and dienogest; the effect in the treatment of endometriosis is achieved due to the presence of dienogest, which is a progestogen. Janine is taken from the first day of the menstrual cycle, the treatment regimen for endometriosis is 21 days, taking pills, 7 days, break.

Yarina

The main components of Yarina are ethinyl estradiol and drospirenone. Drospirenone is a gestagen that has a therapeutic effect on foci of endometriosis. The drug is taken according to a similar scheme to Janine. According to reviews, after discontinuation of the drug, the symptoms of the disease return.

Progestogens

Progestogens remain the main hormonal drugs for the treatment of early stage endometriosis. They affect the hypothalamus-pituitary gland and ovaries, reducing the production of estrogen, and have a direct effect on the endometrium - when taking progestogens without interruption, it atrophies and the foci of endometriosis, respectively, too. Under their action, estradiols are converted into estrogens (they are less active), and the production of prostaglandins, which have a beneficial effect on the synthesis of estrogens, slows down.

The course of hormonal therapy using progestogens should be long and high-dose, it should lead to a complete cessation of menstruation (artificial menopause). The onset of “false menopause” prevents the appearance of new lesions, relieves pain, and reduces existing pathological lesions.

The disadvantage of these hormonal drugs is long-term use and large doses - this does not meet modern requirements: “minimum dose - maximum effect,” but at the same time they have additional therapeutic effects (antiandrogenic and others). With continuous use, there is a high probability of breakthrough bleeding, but with further use of the drugs, the risk of this adverse event decreases.

Dienogest (trade name Visanne)

Dienogestil, the drug Visanne, for endometriosis is used in the lowest dose - 2 mg per day (for comparison, dydrogesterone, 40-60 mg per day). It belongs to the fourth generation progestogens, which were obtained by combining synthetic progesterone derivatives: 19-nortestosterone and 17-hydroxyprogesterone. As a result of this, dienogest began to have an antiandrogenic effect, which was absent in earlier “versions” of gestagens.

The advantages of dienogest are its strong progestogenic activity, due to which it has a positive effect on the endometrium (it does not grow), due to its rapid elimination, it almost does not accumulate in the body, so it can be taken for quite a long time. It does not have a destructive effect on metabolic processes in the liver and does not cause a critical decrease in estrogen levels, copes well with the painful manifestations of endometriosis and is relatively safe compared to other hormonal drugs for endometriosis.

Dydrogesterone (trade name - Duphaston)

It is prescribed for a lack of progesterone and has a beneficial effect on the endometrium, reducing the risk of its growth. It is necessary to take Duphaston continuously, due to the ineffectiveness of cyclic dosing. The drug Duphaston is often prescribed for infertility due to endometriosis, but it is important to understand that its use is only relevant in cases of confirmed progesterone deficiency.

Utrozhestan

The drug Utrozhestan is an analogue of Duphaston, but its instructions for use do not include endometriosis in the indications section. The advantages of Utrozhestan are that the progesterone contained in it is obtained from plant components, so it is considered a more natural preparation. In addition, it is possible not only to take it orally, but in the form of vaginal suppositories.

Important! Taking Visanne, Duphaston, Utrozhestan does not exclude the possibility of conception; to exclude unwanted pregnancy, you need to use a condom.

Depo-Provera

Depo-Provera is available as an injection for endometriosis and is also used as a contraceptive. The main active ingredient in this drug is medroxyprogesterone in the form of acetate, hence the non-trade name for medroxyprogesterone acetate depot (DMPA). The analgesic effect of DMPA is comparable to gonadotropin-releasing hormone agonists (GnRH), but the number of side effects is also significant. One of the serious consequences for the patient is the occurrence of prolonged, uncontrolled breakthrough bleeding.

It is ideal to prescribe Depo-Provera for the treatment of residual endometriosis after hysterectomy, in which case there is no possibility of uterine bleeding. To ensure that bone mineral density is not significantly affected, it is best to use intrauterine DMPA.

Levonorgestrel-releasing intrauterine system (Mirena device)

The Mirena intrauterine device is used in the treatment of endometriosis; in addition, it is a contraceptive. Compared to other progestogens used in the treatment of endometriosis, the daily dose of levonorgestrel, which goes directly into the uterus - 20 mg - is insignificant. It does not suppress ovulation, and some patients develop amenorrhea or absence of menstruation. It copes well with pain, but after removal there is a high probability of relapse of the disease.

Antigonadotropins

Antigonadotropins prevent the pituitary gland from producing gonadotropins: follitropin or follicle-stimulating hormone (FSH), lutropin or luteinizing hormone (LH). Under the combined action of these hormones, estrogens are produced, and thanks to their blockade, the secretion of estrogens is suspended and, accordingly, the endometrium does not grow.

The main representatives of antigonadotropins are danazol and gestrinone.

Danazol (Danocrine, Danoval, Danogar, Cyclomen)

Previously, danazol was actively used in hormonal therapy for endometriosis, but nowadays it is rarely used due to the large number of side effects. During the first two months of treatment, menstruation should stop, the maximum duration of the course is 6 months, a month after the end of menstruation they should resume.

Very common side effects during treatment with danazol: excess weight, the appearance of “extra” hair, deepening of the voice, tachycardia, strong libido, and more.

Gestrinone (Nemestran)

The drug is taken without interruption from the first day of the menstrual cycle - 2 times a week, it also introduces the patient into an artificial menopause, after 4 months of treatment - pain associated with menstruation and intimate relationships disappears in almost 100% of patients, but after 1-1, After 5 years, more than 50% of women experience a return of all symptoms.

If you have endometriosis, you cannot take these pills for a longer period of time due to severe side effects (weight gain, shrinkage of mammary glands, deepening of the voice, etc.)

Gonadotropin-releasing hormone agonists (GnRH agonists)

These hormones for endometriosis are considered the most “powerful” both in terms of their effect and the number of adverse reactions. It is advisable to use them for the treatment of severe forms of the disease. They can be in the form of tablets, intramuscular injections, subcutaneous implants and intranasal sprays. The group of these drugs includes zoladex (goserelin), buserelin, diferelin and others.

The mechanism of action of GnRH is as follows: gonadotropins are blocked, which in turn causes a pronounced estrogen deficiency, while foci of endometriosis begin to decrease in size, and almost all pain symptoms of the disease disappear. But when treated with GnRH, the disease can recur; according to statistics, 5 years after a course of treatment in severe forms of the disease, relapses occur in more than 50% of cases.

The patient should know that when treated with GnRH, she will encounter all the manifestations of “artificial” menopause: hot flashes, vaginal dryness, decreased libido, breast reduction, mood swings. In addition, bone mineral density will decrease rapidly, which threatens the development of osteoporosis. In some cases, even recurrent hormonal therapy, which is aimed at restoring estrogen balance, does not help.

The maximum duration of treatment with GnRH agonist is 6 months; in combination with recurrent hormonal therapy, the duration of administration can be increased.

With a long course of treatment, there is a real threat of a decrease in the supply of eggs, which means that young women may begin menopause, so more serious hormone replacement therapy (HRT) is prescribed to replace estrogen levels.

To restore the balance of estrogen, oral contraceptives should not be used; HRT drugs (Divina, Klimen, Klimonorm) are better suited for this purpose. When taking GnRH agonists together with HRT drugs, it is necessary to monitor biochemical blood parameters (take regular blood tests) and bone mineral density.

Aromatase inhibitors

Aromatase inhibitors are substances that inhibit the action of the aromatase enzyme. Aromatase converts androgens into estrogens; as is known, estrogens provoke the development of this disease, but the main producer of estrogens before menopause is the ovaries, so the effect of aromatase is noticeable after menopause, because During this period, the ovaries “turn off” and aromatase becomes the main producer of estrogen.

In the treatment of severe, constantly recurrent forms of endometriosis, aromatase inhibitors are used. These include Arimidex, Anastrozole, Exemestane and others. The difficulties in using these drugs are as follows:

• They should be prescribed only to women in menopause; if they are used to treat young patients, then the ovaries must be “artificially” switched off, otherwise large cysts will form on them.
• With long-term use, bone density decreases; in order to reduce this side effect, COCs or progestogens are prescribed in parallel; in this case, treatment becomes expensive and is inaccessible to most women.

The results of the study showed that after 6 months of taking aromatase inhibitors in parallel with COCs in high doses, it led to a significant, but not absolute, reduction in all pain (while previously prescribed treatment did not help the patients), bone mineral density did not decrease with this course duration. But there are few studies confirming the safety of aromatase inhibitors, so they are currently not used for most patients.

Contraindications to hormone treatment

When prescribing hormone therapy for endometriosis, a doctor must also prescribe certain clinical studies to determine whether the patient has any contraindications to a particular drug.

It is also advisable for the patient to read the instructions (contraindications section) that come with each hormonal drug.

General contraindications for taking hormones:

• Individual intolerance to the drug.
• Cardiovascular diseases, in which the risk of stroke, heart attack (thrombophlebitis, etc.) is increased.
• Serious liver diseases (cirrhosis, failure).
• Oncological diseases.
• Pregnancy (but not always, for example, Duphaston is used during pregnancy) and lactation period.
• Smoking.

Combined oral contraceptives

Low-dose oral contraceptives are widely used in the treatment of endometriosis in young women. They minimize the effects of male hormones. When women take the pills, the greasiness of their skin and hair decreases, and the amount of acne is noticeably reduced. This therapy is often carried out in combination with surgery. If the operation is not performed, then the medicine for uterine endometriosis is taken for 6-9 months.

The following medications are considered the most effective:

• "Silhouette". These are hormonal tablets of a combined type. They have antiandrogenic and anti-inflammatory properties. Active ingredient: ethinyl estradiol. The medicine “Silhouette” for endometriosis is taken daily, one tablet per day. The therapeutic course is at least three weeks. The cost of the drug is about 700 rubles.
• "Norkolut." The medication is very quickly absorbed into the gastrointestinal tract. Effective two hours after administration. Contains the active component – ​​norethisterone. The drug is taken from the fifth to the fifteenth day of the menstrual cycle. Daily norm: 5 ml. The duration of the course is six months. Price 350 rubles.
• "Yarina." The medicine has antiandrogenic properties. Reduces the activity of the sebaceous glands. Reduces the amount of acne. The medicine for endometriosis is taken every day for three weeks. The duration of treatment is regulated by the doctor. The drug costs about 500 rubles.
• "Regulon". It is a contraceptive multiphase drug. Contains two active ingredients: ethinyl estradiol and desogestrel. The tablets activate the secretion of sex hormones. They are drunk daily. The course is 21 days. The price of the medicine is about 300 rubles.
• "Klayra." Combination type contraceptive drug. Its action is based on the properties of two active ingredients: dienogest and estradiol valerate. The medicine changes the quality of the cervical fluid, which suppresses the ovulation process. Course - 28 days. The drug costs around one thousand rubles.
• "Novaring". The drug is presented in the form of a special ring for the vagina. Contains two active components - etonogestrel and ethinyl estradiol. The medication is inserted into the vagina for 21 days. Price 380 rubles.
• "Jess." Characterized by antiandrogenic properties. Active ingredients: drospirenone and ethinyl estradiol. Taken orally. The duration of treatment is 28 days. The tablets cost around 1000 rubles.
• "Novinet." Suppresses ovulation. Stabilizes the quality of cervical mucus. Contains ethinyl estradiol with desogestrel. The medicine is taken for three weeks, then a 7-day break is taken. After which the course of treatment is continued. Price 600 rubles.
• "Logest". Contains ethinyl estradiol in combination with gestodene. Suppresses ovulation processes. Normalizes the condition of cervical mucus. The tablets are taken orally for 21 days. Then they take a break for a week. If necessary, treatment is continued.

These drugs should be taken at the same time. If the medicine is prescribed without a seven-day break, then menstruation does not come.

Treatment and prevention

Hormone therapy is the best treatment option for endometriosis. Not only are the unpleasant symptoms of the pathology eliminated, but also, unlike surgical intervention, the function of childbearing is preserved.

Contraceptives include synthetic analogues of sex hormones - estrogen and progesterone. Contraception for endometriosis not only protects against conception, but also has a therapeutic effect in the treatment of gynecological diseases.

After a thorough examination and based on test results, the gynecologist selects the remedy that is most suitable for the woman.

Hormonal therapy helps in the treatment of endometriosis only in the initial stages of the development of the pathology.

These are drugs similar to progesterone. Their main function is to suppress the growth of the uterine mucosa.

The main drugs in this series are as follows:

1. Duphaston. Available in tablet form. It must be taken from the 5th to the 25th day of the menstrual cycle.
2. Byzanne. Take 1 tablet daily. It begins to act after the growth of the endometrium stops, the ovaries stop functioning, and menstruation stops.
3. Orgametril. Indicated to prevent the development of new foci of pathology and reduce the size of existing ones. It is recommended to take 1 tablet every day from days 14 to 25 of the cycle.

Medicines can be prescribed in tablet form or by injection.

Gonadotropin-releasing antagonists

Representative of the class of hormones of the hypothalamus. The use of this remedy does not completely cure, but only stops the progression of the disease. This is necessary so that the woman’s body can prepare for pregnancy, gestation and childbirth. Prescribed in cases where surgical intervention is contraindicated.

Buserelin is usually used. It causes a condition similar to menopause in the body. The product is highly effective, but when used for three months it often leads to the development of osteoporosis.

It is recommended to take hormonal medications only as prescribed by a gynecologist. Self-medication can lead to negative consequences.

Antiprogestins

The drugs Danazol and Mifepristone have a suppressive effect on female hormones. Menstruation stops, which is subsequently restored. They are considered effective means, although they have disadvantages.

"Janine" for endometriosis

"Janine" is the most popular medicine for uterine endometriosis. In patients who took this medication, the disease regressed over a long period of time. My health has noticeably improved.

"Zhanine" belongs to the latest generation of drugs. It is a low-dose hormonal medicine. Contains dienogest in combination with ethinyl estradiol. It is quickly absorbed and begins to act immediately. Inhibits the production of hormones, resulting in a reduction in the amount of estrogen. The pills prevent the onset of ovulation. You cannot get pregnant when using them. The drug also reduces the contractility of the fallopian tubes. Makes it difficult for the egg to move forward.

Gynecologists prescribe “Zhanine” to prevent the growth and development of the disease focus. To suppress pain and inflammation.

This medicine for endometriosis has only positive reviews. Ladies note that while taking this product, their pain disappeared, the condition of their nails and hair improved, and their skin became clearer. The drug also helped women with hirsutism. Representatives of the fairer sex recommend these pills to those who have an excessive amount of androgens in the body.

"Janine", like other similar contraceptives, is indicated for endometriosis at the initial stage of development. The drug can be prescribed before surgery and after surgery to prevent relapses.

To achieve results, you should drink “Janine” for at least nine months, continuously. The drug is prescribed strictly according to indications and after a detailed examination of the woman. The medicine has contraindications and can cause side effects, so you should not take it without a doctor's prescription. The cost of “Zhanina” varies between 800 rubles.

In order to reduce the negative impact of hormonal drugs for endometriosis, hepatoprotectors, such as Karsil or Essentiale, are additionally prescribed. Enzymes (Pancreatin, Creon) may be prescribed. To protect the stomach, sea buckthorn oil, Gastal, Methyluracil and others are recommended.

Non-hormonal drugs

Many women dream of curing endometriosis without hormones, but today non-hormonal treatment is considered ineffective. Non-hormonal drugs that are used in the treatment of endometriosis include non-steroidal anti-inflammatory drugs (NSAIDs), drugs based on natural, herbal ingredients, and suppositories. As a rule, they only have an analgesic effect and have little or no therapeutic effect on the foci of endometriosis.

Anti-inflammatory drugs (NSAIDs)

For a long time, anti-inflammatory pills for endometriosis were used to relieve premenstrual and chronic pain. However, there was little research on their effectiveness; over time, it was discovered that with prolonged use and at high doses, they cause significant harm to the cardiovascular system (the risk of stroke and heart attack increases).

NSAIDs include ibuprofen, diclofenac, rofecoxib and others.

Anti-inflammatory drugs for uterine endometriosis make sense to use for short-term pain relief, especially when awaiting surgical treatment or in the case of the first month of taking GnRH agonists (in this case, a short-term increase in pain during menstruation may occur due to the initial effect on the hypothalamus-pituitary-ovaries ).

Antibacterial drugs

Antibiotics for endometriosis are not prescribed for its treatment; they are used only if any inflammatory process occurs (is detected) that occurs in conjunction with it. Endometriosis is not a contraindication for the use of antibacterial drugs.

They are appointed if:

• Inflammatory diseases occur in the uterus - endometritis, endocervicitis.
• Infectious processes develop in the genitourinary system (cystitis, urinary tract infections, urethritis, etc.).
• Fungal infections appear.

Gestagens

What medications are prescribed for endometriosis? In the treatment of this disease, a variety of drugs can be used, including gestagens. We have already mentioned these drugs, but it is worth considering this group of drugs in more detail. These medications are substitutes for progesterone, a female hormone produced by the corpus luteum of the ovary. This substance is synthesized at the site of the burst follicle, after the ovulation process. It has a positive effect on hormonal levels and improves the structure of the endometrium.

The best drugs for endometriosis in this group include the following drugs:

• "Duphaston". The drug is prescribed to be taken from days 5 to 25 of the menstrual cycle. Then they take a week's break and resume taking the medication. Daily dose 10-20 mg.
• "Norethisterone." The treatment regimen is similar to Duphaston. The maximum permissible daily intake is 5 mg.
• "Mirena". Intrauterine device. The active substance is levonorgestrel.
• "Utrozhestan". The drug is prescribed from the 16th to the 25th day of the menstrual cycle. The treatment course can last up to 9 months. Judging by the reviews, it helps to cope with pathology.

The medicine for endometriosis, Visanne, deserves special attention. It is used most often. The drug showed simply excellent results in the treatment of this disease. The medication is taken one tablet a day for about a year.

The drug reduces the lesions and reduces the number of vessels that provoke the appearance of endometriosis, which significantly reduces the trophism of the disease. Side effects when taking Visanne are rare. As a rule, this is a disorder of the gastrointestinal tract, pain in the abdomen, headache, skin rashes and depression.

Spiral "Mirena"

What medications treat endometriosis effectively? These are the drugs that were described above. Not least among them is the Mirena intrauterine device.

The therapeutic system suppresses endometrial growth. Contains levonorgestrel, a substance that is an analogue of the female hormone progesterone.

The spiral affects the woman’s body locally, as a result of which less hormones enter the body than when using tablet drugs.

Mirena normalizes the menstrual cycle, reduces the duration of menstruation and the amount of bleeding. Removes pain.

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Endometriosis in a mild stage of development can be easily cured with this medication. At the beginning of using the spiral, spotting may be observed. But, after some time, the situation changes dramatically. The cycle is leveling out. And your periods become shorter and less abundant. For some women, after installing the IUD, menstruation stops altogether. This is a positive thing for endometriosis.

Antigonadotropic drugs

A gynecologist talks about what medications to take for endometriosis. As a rule, if the disease is not advanced, then to treat it, medications are prescribed that stop the production of pituitary hormones. After all, they actively stimulate the work of the ovaries. They inhibit the synthesis of LH and FSH.

We have already mentioned the list of the most popular drugs in this group, but it is worth going over them in more detail. When using these drugs, the patient experiences artificial menopause and estrogen production is reduced to a minimum level.

The best medicines in this group include:

• "Buserelin." Available in spray form. Used for about 4-6 months. Three instillations are administered daily into each nasal passage.
• "Buserelin Depot". Available in ampoules. Used as injections. The drug is administered once a month, intramuscularly.
• Zoladex. The medicine is produced in the form of subcutaneous capsules. Injected under the skin every 28 days.
• "Danazol". Produced in capsules for oral administration. Refers to antigonadotropins. It is characterized by a slight anabolic effect. Slows down the growth of the endometrium. Prevents the onset of ovulation. Blocks the synthesis of sex hormones. Daily dose 400 mg. Judging by the reviews, this is a fairly effective drug.

This group of drugs is prescribed before and after surgery to prevent the growth of lesions. The drugs are difficult to tolerate by patients and can cause a number of negative effects. The duration of their use is 6-9 months.

Your doctor will tell you which medications are best to take for endometriosis. It will be based on the symptoms of the disease and the severity of the pathology.

Reviews

I suffered from terrible pain, I went to see a gynecologist and was diagnosed with endometriosis. Initially I took Norkolut (progetsagen) and it didn’t help at all, then I put on the Mirena coil for 5 years and forgot about the pain, I calmed down, but as soon as I removed it the problems started getting even worse , a month later uterine bleeding began, then numerous new lesions were discovered, in general one problem, now I hope for surgery.

After laparoscopy, they discovered multiple endometriotic lesions, prescribed me treatment with injections of buserelin (GnRH) for 6 months, I was very afraid of side effects, but surprisingly everything was quiet and calm, after 2 months menstruation disappeared, hair and skin remained the same, there was no depression, on the contrary I became calmer and more confident, after 5 months I had a repeat laparoscopy and did not find a single focus of endometriosis.

For a long time I dreamed of becoming a mother, but everything was unsuccessful, I went to doctors and only after 3 years a good doctor discovered that I had an endometroid cyst. The first drug I started taking was Duphaston, it didn’t help, on the contrary, the cyst got bigger. The doctor suggested taking 6 injections of diferelen (once a month). After the injection, the sensations were terrible - ebbs and flows, a terrible mood, and the cost of the drug was very high, but after 3 months the doctor stopped the course and said that I could get pregnant and after six months everything worked out for me. I don’t know how my drug helped endometriosis, because pregnancy and breastfeeding are the best treatment for her, now I am a mother of two children.

Non-hormonal treatment for endometriosis

In addition to hormonal drugs, non-hormonal drugs can also be used in the treatment of endometriosis, these are:

• Immunomodulators. Such as: “Levamisole”, “Polyoxidonium”, “T-activin”, “Licopid”, drugs with interferon and others.
• Non-steroidal anti-inflammatory drugs. They relieve inflammation and relieve pain. The most effective are Diclofenac, Naproxen, Ibuprofen, Indomethacin. They are used five days before the onset of menstruation.
• Natural herbal remedies. These medications for ovarian endometriosis cause fewer side effects than hormonal medications, but they are less effective. It takes much longer to achieve the desired effect. Despite their naturalness, they should not be used without a doctor’s prescription. Most often, Cyclodinone and Gynecol are used for endometriosis.
• Dietary supplements. These products do not cure endometriosis and have not been fully tested in clinical trials, but their use may improve the outcome. The most common are Indole Forte and Ovariamin.

If there are certain indications, antibiotics may be prescribed to treat endometriosis. But these medications are rarely used, as they stimulate the development of the disease and provoke endometrial growth.

Can endometriosis be cured with medications?

Today, endometriosis is recognized as a chronic disease. None of the methods of treating endometriosis guarantees complete recovery and the disease can recur at any time.

The main objectives of surgical and drug treatment of endometriosis are:

• Reduction and removal of existing lesions.
• Reducing the severity of pain symptoms.
• Prevention of the emergence of new lesions.
• Getting rid of infertility.

In addition, taking medications for uterine endometriosis allows you to avoid surgical treatment in some cases.

Herbs for endometriosis

Medicinal plants are indispensable assistants in the treatment of pathology. Reviews from women say that with constant use, herbs can provide lasting results. So, plants that are used for endometriosis include:

• hog uterus;
• red brush;
• nettle;
• collections with elderberries, raspberries and blackberries;
• celandine.

From herbs you can prepare decoctions, make alcohol tinctures and douches.

Do not forget to consult a doctor before using medicinal plants. And you should not replace therapy prescribed by a gynecologist with herbs. This can completely trigger the disease and provoke complications and serious health problems.

Question: How to choose contraceptives for endometriosis?

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

What contraceptives should you take if you have endometriosis?

Endometriosis

is a hormonal-dependent disease that occurs in women of childbearing age.
This disease is characterized by the fact that endometrial cells ( the mucous layer of the uterus
) grow to form benign tissue that can spread within the uterus (
genital endometriosis
) and beyond (
extragenital endometriosis
).

Very often, endometriosis is asymptomatic, but in most cases the main symptom with which many women turn to a gynecologist is the inability to conceive a child ( infertility

).

Also, with endometriosis, a woman may experience the following symptoms:

• pain in the lower abdomen;
• bleeding during menstruation becomes longer and more abundant;
• pain during sexual intercourse;
• pain when urinating;
• pain during bowel movements;
• infertility.

Hormonal contraceptives.

Hormonal contraceptives contain analogues of female sex hormones - estrogen and progesterone. These contraceptives

provide not only a reliable contraceptive effect, but also have a healing effect on the body. Hormonal contraceptives are used in the treatment of diseases such as endometriosis, uterine fibroids, endometrial polyps, etc.

The mechanism of action of these hormonal contraceptives is as follows:

• inhibit ovulation;
• thicken cervical mucus in the cervical area;
• block the growth of the uterine mucosa;
• block endometrial metastasis in endometriosis.

In addition, hormonal contraceptives are used to prevent endometriosis and also reduce the likelihood of relapse ( recurrence

) diseases.

Who can and who can't

In any case, COC continues to be a medicinal procedure. Oral contraception has its own indications, contraindications and features.

Advantages

The advantages of this therapy are:

• Reducing the development of endometriosis or stopping the growth of a benign tumor (before a planned pregnancy, before surgery).
• The presence of a contraceptive effect (but the drug does not protect against HIV infection, AIDS, sexually transmitted diseases).
• Relative availability and different price range. Much depends on the dose of hormones in each tablet; sometimes the cost is affected by the popularity of the manufacturer.
• A small list of side effects (often individual rejection). Headaches and nervousness are possible.
• Habitual sensations during intimacy.
• Sometimes weight correction is observed, and the condition of hair and skin improves.
• Convenient use (just take a tablet).

Contraindications

But sometimes COCs may be contraindicated for a number of medical reasons:

1. If endometriosis spreads outside the uterus, questions may arise about the advisability of such treatment.
2. Presence of diseases of the endocrine system (in particular diabetes).
3. Kidney and liver diseases.
4. Ailments affecting the cardiovascular system (tendency to blood clots, high blood pressure, heart pathologies).
5. Pregnancy and breastfeeding.

Such contraindications are due to the broad effect of hormones on the body, not only on the reproductive system.

If there is a disease in other organs, the doctor should, together with the COC (or before use), also suggest those drugs that will provide a supporting function, for example, the kidneys or liver.

For varicose veins, therapy is also carried out, since COCs provoke thrombus formation.