What does Lincomycin help with? instructions for use

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Many dental diseases require treatment with antibacterial agents.

Depending on the characteristics of the inflammatory process, drugs of various groups are prescribed. One of the commonly used drugs is Lincomycin.

Due to its wide spectrum of action, Lincomycin is used for drug therapy for pathologies whose development was provoked by gram-positive flora.

By changing the dosage, it is possible to ensure that the drug is present in the body in the concentration necessary to achieve a certain clinical effect.

Description and composition

The gelatin capsules are white and contain a white powder inside that can compact, but should disintegrate when pressed with a glass rod.

Each capsule contains:

• active ingredient: 250 mg lincomycin;
• auxiliary components: potato starch, granulated sugar, E 572.

The shell consists of the following components:

• gelatin;
• glycerol;
• titanium oxide;
• purified water;
• sodium lauryl sulfate.

The injection solution is a colorless liquid.

1 ampoule contains:

• active ingredient: 300 mg lincomycin;
• additional components: Trilon B, caustic soda, water for injection.

The ointment is a homogeneous mass of white or yellowish color.

As an active substance, 15 g of the drug contains 300 mg of lincomycin.

It also includes the following auxiliary components:

• potato starch;
• petrolatum;
• zinc oxide;
• petroleum paraffin solid.

The drug Clindamycin

This is a semi-synthetic analogue of Lincomycin. Clindamycin is the second representative of the lincosamide group. It is available in the form of capsules, granules for suspension and solution for injection. "Clindamycin" can be purchased under the following names: "Dalacin", "Klimitsin", "Clindafer", "Klinoxin". These are newer drugs from the lincosamide group, without some disadvantages:

• they are more active against bacteria;
• better and faster absorbed from the gastrointestinal tract;
• their effectiveness does not depend on food intake;
• They are active against protozoa, so they are often used in the treatment of chlamydia and other vaginal infections.

But Clindamycin often causes side effects such as pseudomebranous colitis. In addition, it costs much more - 130-150 rubles.

This page provides a list of all Lincomycin analogues by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Lincomycin:
• The most popular analogue of Lincomycin:
• ATC classification:
  Lincomycin
• Active ingredients/composition:
  lincomycin

Pharmacological group

The active substance inhibits protein biosynthesis in bacterial cells.

Lincomycin is mainly active against gram-positive bacteria:

• staphylococci, including strains that produce penicillinase;
• streptococci;
• clostridia;
• bacteroides;
• diphtheria bacillus;
• mycoplasma.

The antibiotic is not effective against most gram-negative bacteria. It is also not active against fungi, viruses, or protozoa.

Cross-resistance has been observed between lincomycin and clindamycin.

After oral administration, 30-40% is absorbed from the gastrointestinal tract. If you take an antibiotic with food, the rate and extent of drug absorption slows down. Lincomycin crosses the placenta, part of it is metabolized in the liver. Excreted through the kidneys and intestines. The half-life is 5 hours.

Precautions for the substance Lincomycin

Should not be combined with muscle relaxants. For severe infections, lincomycin is combined with aminoglycosides or other antibiotics that act on gram-negative bacteria. Prescription to patients with liver failure is permissible only for health reasons. With long-term use, systematic monitoring of renal and liver function is necessary. If pseudomembranous colitis develops, discontinue treatment and administer vancomycin or bacitracin. Rapid intravenous administration should be avoided. When applied topically, caution should be exercised in case of dermatomycosis.

Indications for use

for adults

Lincomycin is prescribed for infections caused by bacteria sensitive to it:

• inflammation and abscess of the lung;
• blood poisoning;
• osteomyelitis;
• infective endocarditis;
• infections of soft tissues and skin (when penicillin antibiotics are contraindicated);
• wound infection.

The ointment is prescribed for purulent-inflammatory skin diseases.

for children

Lincomycin can be prescribed for the above infections in children older than 1 month.

for pregnant women and during lactation

The antibiotic penetrates the placenta and into breast milk. Therefore, it should not be taken during pregnancy. When transferring a child to artificial feeding, the drug can be taken for the diseases listed above.

Local antibiotics

To speed up the recovery process, adults and children are prescribed local antibiotics. With this treatment, you can gargle with solutions of medications, inhalations, or treat the tonsils.

When treating tonsillitis locally with antibiotics, penicillin solutions are used. It is used to wash inflamed lacunae. Perform manipulations for 7-10 days. To perform them, you need to use a syringe and the drug Tonsilor.

On video, antibiotics for acute tonsillitis in an adult:

Even when treating angina in adults and children, antibacterial drugs can be administered intratonsillar or paratonsillar. Thanks to them, it is possible to eliminate pus and bacteria that are concentrated in the depths. Drugs from a number of penicillins are injected into the tissue of the palatine tonsils.

Applications and dosages

for adults

The drug is prescribed in capsules at 500 mg 3-4 times a day. They should be swallowed whole with water before or after meals.

The antibiotic is administered intramuscularly in a single dosage of 600 mg 1 or 2 times a day.

The drug is administered intravenously by drip, having previously diluted 600 mg of lincomycin in 250 ml of saline and a solution of 5% glucose.

The ointment is applied in a thin layer to the affected areas.

The average duration of therapy is 10 days.

For kidney or liver diseases, the dosage is reduced by ½-1/3 and the interval between taking the medication is increased.

for children

The treatment regimen is selected individually depending on the severity of the infection.

The drug is prescribed orally for children aged 1 month to 14 years in a daily dosage of 30 to 60 mg per kg of weight.

Children of this age are given intravenous antibiotic drips at a dosage of 10 to 20 mg per kg; the drip should be placed every 8-12 hours.

For children over 14 years of age, the drug is prescribed in the same dosages as for adults.

The ointment is applied in a thin layer to the infected areas of the skin.

For pathologies of the liver and kidneys, the dosage is reduced by 1/3-½ and the interval between doses is increased.

for pregnant women and during lactation

Lincomycin is not prescribed to pregnant patients. After transferring the child to formula, the drug can be taken as usual during lactation.

Lincomycin instructions for use

Analogs of the drug have the same composition and mode of action.
They can be purchased under several names: “Tsilimicin”, “Neloren”, “Medoglycin”, “Linosin”, “Lincocin”. All of these drugs are equally effective against gram-positive bacteria. They are especially often used against streptococci, which are resistant to other antibiotics. These drugs are available in tablets or capsules, most often 500 mg. They should be taken several hours before meals, since any food greatly reduces the effectiveness of the action. Usually the medication is prescribed 3-4 times. The duration of treatment is 1-2 weeks. But for complex infections of the skin, soft tissues and skeletal system, it can be extended to 3 weeks. After all, resistance of microorganisms to Lincomycin, if developed, occurs very slowly.

Side effects

Lincomycin may cause the following side effects:

• nausea, vomiting, loose stools, stomach pain, inflammation of the tongue, stomatitis, transient increase in the activity of liver enzymes and bilirubin in the blood plasma, pseudomembranous colitis;
• decrease in the number of neutrophils, leukocytes and platelets;
• thrush;
• allergies: urticaria, angioedema, anaphylaxis, exfoliative dermatitis.

With intravenous use, phlebitis may develop; if the drug is administered quickly, the following may occur:

• drop in blood pressure;
• general weakness;
• vertigo;
• relaxation of skeletal muscles.

Price

The price of the medicine is set by the manufacturer and adjusted in city pharmacies. Currently, one package of twenty tablets costs 10 rubles.

Would you like to read the instructions for using Viburkol suppositories for children? Then you should follow the link and read the article. You can read what are the reasons for treating yellow plaque on the tongue in adults using the link provided.

And you can read about how to quickly cure herpes on the lip at home by following the link.

Interaction with other drugs

When prescribed with penicillin and cephalosporin antibiotics, chloramphenicol or erythromycin, antagonism of the antibacterial effect may be observed.

When combined with aminoglycosides, a synergistic antimicrobial effect is possible.

When used together with drugs for inhalation anesthesia or curare-like drugs, an increase in neuromuscular blockade is observed, which can cause respiratory arrest.

Taking antidiarrheals weakens the effect of lincomycin.

Lincomycin is pharmaceutically incompatible with ampicillin, magnesium sulfate, barbituric acid derivatives, theophylline, calcium gluconate, heparin.

The antibiotic solution cannot be mixed with kanamycin or novobiocin.

Dosage form of Lincomycin

Lincomycin is offered for use in the following dosage forms:

1. Capsules containing 250 mg of the active substance – Lincomycin hydrochloride. Components that provide auxiliary action are colloidal silicon dioxide, cellulose, calcium stearate. White crystalline powder with a bitter taste dissolves easily in water, but more difficult in an alcohol-based solution.
2. Each ampoule of injection solution contains 0.3 grams of lincomycin hydrochloride.
3. The ointment contains 300 milligrams of the active component lincomycin and auxiliary elements such as paraffin (hard petroleum and soft white), zinc oxide and potato starch (per 15 grams of ointment in a tube).

Note! The form of release of the drug differs depending on the desired concentration and speed of action on the body.

Analogs

The following medications can be used instead of Lincomycin:

1. Clindamycin is a substitute for Lincomycin in the clinical and pharmacological group. The drug is available in an injection solution, capsules for oral administration, vaginal suppositories and cream. The drug can be used in children over 3 years of age. It is not recommended for pregnant and breastfeeding patients.
2. Macropen is a substitute for Lincomycin in the therapeutic group. The medicine is produced in granules for making a suspension and tablets. The medicine can be used in patients in the first year of life, pregnant women. Antibiotic therapy is incompatible with breastfeeding.
3. Augmentin is a substitute for the drug Lincomycin in the pharmacological group. The antibiotic can be prescribed to children, including infants, pregnant and lactating women.
4. Hemomycin contains azithromycin as an active ingredient. It can be prescribed to children over 6 months of age and pregnant women. During antibiotic therapy, breastfeeding should be interrupted.

Features of the use of Lincomycin and its analogues

These drugs have been used in medicine for a long time. After all, some microorganisms are insensitive to penicillins and other groups of antibacterial drugs, in this case “Lincomycin” turns out to be effective. Analogues in tablets are used for sepsis, postoperative complications, osteomyelitis, purulent arthritis, furunculosis, pneumonia.

The drug has been used in dentistry for a long time. It is more effective than other antibiotics in treating periodontitis, gingivitis, and preventing the development of caries. The best analogue is the Diplen Denta L patch. It is glued to the affected area of ​​the gum for 6-8 hours, during which the active ingredients destroy bacteria.

Lincomycin should be taken only as prescribed by a doctor. Analogs of the drug, like itself, are incompatible with many other drugs, so you should not use them for treatment yourself. It is contraindicated to use Lincomycin in combination with cephalosporins, aminoglycosides, muscle relaxants, barbiturates, Theophylline and some other drugs.

Lincomycin®: reviews of tablets and injections

Most patients respond positively to the drug. First of all, its relatively low cost and mild side effects are noted. However, frequent repeated courses, judging by reviews, reduce the therapeutic effectiveness of the antibiotic and cause negative effects on the liver and kidneys.

However, proper use in full accordance with the intended purpose helps to get rid of many serious diseases. For example, most patients noted the exceptional effectiveness of the drug Lincomycin® for sinusitis, purulent skin lesions and inflammation of the respiratory tract. Thus, consulting a doctor and following his recommendations will make the treatment effective and help avoid negative consequences.

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Edited by A. Chernenko

Infectious disease doctor of the highest category with many years of experience. Specialist in the field of therapy of infectious diseases of various etiologies, methods of laboratory diagnostics of biomaterial.

What is Lincomycin?

Lincomycin in ampoules
Quite often, when the gums are damaged, pus begins to accumulate in the oral cavity or inflammation occurs. These situations necessarily require the use of drugs from the group of antibiotics.

In dentistry, the most advantageous remedy is Lincomycin, which, thanks to its composition, helps to quickly eliminate inflammation and suppress bacterial proliferation , since protein compounds simply do not reproduce.

This allows the drug to have a wide spectrum of action in the dental field. The ability to vary Lincomycin helps to cope with various aspects of the disease.

Composition of the drug

The main active substance in the drug is lincomycin hydrochloride. Since dentists primarily use capsules, sodium hydroxide and disodium edetate are added to create a normal injection solution.

There is no optimal content of it in one capsule, so the concentration and the composition itself may vary slightly depending on the manufacturer. There are also Lincomycin tablets and ointments, each of which has its own range of uses. The most common additional substances are calcium stearate, aerosil and microcrystalline cellulose.

Pharmacology

Lincomycin ointment
The drug Lincomycin, as an antibiotic, relies on its effect on suppressing microbes and having an antibacterial effect. By varying the dose of the drug, the dentist can solve the following problems in the inflamed oral cavity:

• a small or medium amount of Lincomycin does not destroy the infection, but only stops the ability of bacteria to reproduce. Inflammations become static and do not spread further;
• a high concentration of the administered drug destroys bacteria and emerging pathogenic flora.

Dental inflammation is caused by gram-positive microbes - these include streptococci, aerobic cocci and anaerobic bacteria. After using Lincomycin, the peptide bonds are broken, so all microorganisms become neutralized for quite a long time.

Bacteria have not yet acquired the ability to quickly get used to the action of Lincomycin. The drug acts as an effective preventative against the development of caries with constant rinsing.

The drug is quickly absorbed from the fatty acids and 50% of the received dose enters the bloodstream, combining with plasma proteins. The best effect occurs 3 hours after taking the drug, gradually being excreted unchanged through feces and urinary secretions.

Side effects and overdose

During therapy for dental diseases or as a result of an overdose, the patient may experience the following consequences:

• pain in the gastrointestinal tract;
• nausea and vomiting;
• anaphylactic shock or Quincke's edema due to an allergic reaction (in rare cases);
• diarrhea;
• dermatitis and other skin diseases;
• candidiasis of the mucous membrane;
• disturbance of intestinal microflora;
• decrease in platelet count.

Advantages of the drug

The main feature of Lincomycin in dentistry is that the active substance can accumulate in the bone tissue in the required quantity. There are other advantages of this antibiotic:

• It acts on most microorganisms, which most often cannot be destroyed with the help of other drugs.
• Bacteria do not develop resistance to this medicine, so it can be used more than once.
• Since lincomycin accumulates in bone tissue, it will inhibit the growth of pathogenic microorganisms for some time after stopping the medication.
• If you take lincomycin in minimal doses, it acts prophylactically, stopping the proliferation of bacteria.
• In case of acute infection, the doctor will prescribe the maximum dose of the drug, which will not only stop the growth of bacteria, but also destroy existing microorganisms.

Causes of inflammatory processes in the oral cavity

About 30 species of permanent bacteria and more than two hundred species of bacteria and fungi live in the mouth, which pass through in transit, coming from food and the environment. Thus, in the periodontal tissues and dental plaque there are a large number of staphylococci, Escherichia coli, Candida fungi, and viridans streptococcus.

But during stressful situations, illnesses and advanced dental conditions, the immune system weakens, which makes it possible for pathogens to quickly multiply in the oral cavity and periodontal tissues

At this point it is very important to start treatment and use antibiotics. For several decades, dentists have preferred Lincomycin.

In the article: first block

Lincomycin® in dentistry

In this area of ​​medicine, it is one of the most prescribed drugs due to its ability to accumulate in bone tissue. It is used for antibiotic therapy of gingivitis, stomatitis, periodontitis and other inflammatory processes accompanied by the formation of pus. It is usually prescribed in the form of an ointment (applied to the affected area three times a day) or capsules. However, in case of particularly severe periodontal pathologies, injections (including into the gums) can be used.

Can be used for injection in combination with the analgesic lidocaine. It is of great preventive value after tooth extraction, as it helps prevent the development of wound infections and other inflammatory complications.

Lincomycin® during pregnancy and breastfeeding

The drug is contraindicated in pregnant women, unless its use is justified for health reasons. In other cases, it is recommended to replace lincomycin with another antibiotic.

While taking lincomycin, breastfeeding is recommended to be temporarily suspended.

Action of the medication

The antibiotic that is part of the drug has a bacteriostatic effect. It inhibits the proliferation of pathogenic microbes by interacting with their ribosomes and destroying peptide bonds. The drug is active against many gram-positive microbes, but has no effect on fungi, enterococci, gram-negative microbes, viruses and protozoa.

According to the instructions for Lincomycin-Akos, pathogens slowly develop resistance to this antibiotic. The bactericidal effect of the drug is manifested when used in high dosages.

pharmachologic effect

The antibiotic Lincomycin has two main spectrums of action, one of which is anti-inflammatory and the other antimicrobial.

The active substance effectively fights bacteria that provoke the development of oral infections. The list of these microorganisms includes aerobic cocci and streptococci.

After using Lincomycin, its components accumulate in the tissues of the oral cavity and stop the inflammatory process. The active ingredients also prevent the proliferation of pathogenic bacteria and help accelerate recovery processes.

The drug begins active activity almost immediately, and 3 hours after administration, it blocks the development of bacteria.

However, Lincomycin hydrochloride monohydrate cannot combat viruses, gram-negative bacteria and fungi.

special instructions

If liver and/or kidney function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of kidney and liver functions is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and vancomycin or bacitracin should be prescribed.

Experimental determination of suitable drugs:

• CLINDAMYCIN
• TETRACYCLINE
• AMICACIN
• ERYTHROMYCIN
• SPIRAMYCIN
• AMPICILLIN
• AZITHROMYCIN
• ROXYTHROMYCIN
• CEFRADINE
• CEFTAZIDIME
• CARBENICILLIN
• PIPERACILLIN

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ATX codes for LINCOMYCIN

J01FF02 (Lincomycin) D06AX (Other antibiotics for external use)

Experimental determination of suitable drugs:

• CLINDAMYCIN Clinical and pharmacological groups 06.024 (Antibiotic of the lincosamide group) 29.052 (A drug with antibacterial action for the treatment of acne) 29.002…
• TETRACYCLINE Clinical and pharmacological groups 06.048 (Combined drug with antibacterial and antifungal action) 06.018 (Antibiotic of the tetracycline group) 26.022…
• AMICACIN 06.015 (Antibiotic of the aminoglycoside group) Semi-synthetic antibiotic of the aminoglycoside group of a wide spectrum…
• ERYTHROMYCIN Clinical and pharmacological groups 29.051 (Drug for the treatment of acne) 26.025 (Antiseptic for topical use in ophthalmology) 29.002…
• SPIRAMYCIN 06.020 (Macrolide antibiotic) Macrolide antibiotic. Has a bacteriostatic effect...
• AMPICILLIN Clinical and pharmacological groups 06.002 (Antibiotic of the broad-spectrum penicillin group, destroyed by penicillinase) 06.005 (Antibiotic of the…
• AZITHROMYCIN Clinical and pharmacological group 07.005 (Combined drug with antiprotozoal, antifungal and antibacterial action) 06.021 (Antibiotic of the…
• ROXITHROMYCIN 06.020 (Macrolide antibiotic) Semi-synthetic antibiotic of the macrolide group. Mechanism of action…
• CEFRADINE First generation cephalosporin antibiotic. Has a wide spectrum of antimicrobial action. Acts bactericidal. Active…
• CEFTAZIDIM 06.010 (III generation cephalosporin) III generation broad spectrum cephalosporin antibiotic…
• CARBENICILLIN Antibiotic of the group of semisynthetic penicillins with a broad spectrum of action. It has a bactericidal effect, suppressing...
• PIPERACILLIN Clinical and pharmacological groups 06.007 (Antibiotic of the broad-spectrum penicillin group with a beta-lactamase inhibitor) 06.003 (Antibiotic…