Mezim

Category: Published 10/10/2016 · Comments: · Reading time: 5 min · Views: 2,941

“Mezim”, what does this enzyme medicine help with? The drug improves digestion processes. The instructions for use recommend taking Mezim tablets for flatulence, dyspepsia, and problems with digesting food. In the world the medicine is known as “Pancreatin”; in Russia its variety “Mezim Forte” is popular.

What is Mezim forte

This medicine belongs to a group of enzyme preparations designed to improve food digestion processes. Doctors recommend using Mezim for diseases associated with pancreatic insufficiency and dysfunction of the gastrointestinal tract. Release form of the drug:

Mezim forte 10000: pink-coated pellets of a flat, cylindrical shape with beveled edges. They are produced in blister packs of 10 pieces, packaged in 20 or 50 pills;
Mezim forte 20000: tablets coated with a smooth white or grayish shell with possible internal brown inclusions, have a pronounced odor. Packed in a blister - 10 pieces, available in packages of 10, 20 or 50 pieces.

Composition release form

Mezim forte 20000 includes the following components:

Pancreatin.
Lipase-3500 units.
Amylase-4200 units.
Protease-250 units.

Additional items:

Cellulose.
Silica.
Sodium carboxymethyl starch.
Magnesium stearate.

The drug shell includes:

Simethicone emulsion.
Talc.
Azorubic varnish.
Titanium dioxide.
Macrogol 6000.

Mezim Forte 10000 consists of the following substances:

Pancreatin-137.5 milligrams.
Lipase-10000 units.
Amylase-7500 units.
Protease-375 units.

Mezim is offered in the form of tablets with a special coating (resistant to the acidity of gastric juice). Thanks to this, the tablets do not immediately dissolve under the influence of hydrochloric acid.

The medication easily penetrates the intestinal cavity and promotes the natural process of breakdown of proteins, fats and carbohydrates in the body.

Benefits and harms of Mezim

The medication is prescribed for digestive disorders, both severe and minor. It is important to remember that regardless of the effectiveness of the medication, course therapy is carried out only with the permission of the doctor. If all rules are followed, the drug has a beneficial effect on the body. By supporting the functioning of the pancreas, Mezim Forte helps to normalize the digestion of carbohydrates, proteins and fats, increase the absorption of valuable substances in the small intestine, and relieve the feeling of heaviness when overeating.

Self-medication, accompanied by an uncontrolled number of tablets, can cause significant harm to patients if Mezim is taken if there are contraindications. Having a powerful effect, in case of overdose the medicine increases the severity of symptoms and leads to poisoning. There are conditions in which drinking pills is strictly prohibited. These include, for example, acute pancreatitis, intolerance to components.

Indications for the use of enzyme tablets

Mezim is a medicine intended both for the treatment of various pathologies and for the prevention of digestive disorders. Gastroenterologists recommend taking the drug before an upcoming celebration, where food that is heavy for the stomach is expected. Mezim will help quickly break down fats and carbohydrates and avoid indigestion. But the main area of use of the drug is to alleviate the human condition with diseases of the digestive tract. These include:

death of beneficial intestinal microflora, causing dyspeptic symptoms;
chronic pancreatitis and cholecystitis;
intestinal dyskinesia;
impaired motility of the digestive tract;
cystic fibrosis;
flatulence.

Mezim is also used for constipation or diarrhea, but only if these symptoms of peristalsis disorders accompany a serious illness. The drug does not have fixative or laxative properties. Only a doctor should treat diarrhea or constipation after determining the cause of its occurrence. Mezim forte is prescribed to patients who are undergoing endoscopic examination or surgery. The drug will help to quickly cleanse the gastrointestinal tract of undigested food residues.

Use in children

Digestive disorders are often diagnosed in young children. Natural curiosity and restlessness help them explore the world, and for parents they become a source of anxiety and worry. Unwashed fruits straight from the tree, berries freshly picked from the bush are put into the mouth by hands that recently petted a stray cat or dog. It is not surprising that after a couple of days the child develops an intestinal infection. Children suffer from the following symptoms:

bloating, rumbling and bubbling;
diarrhea or constipation;
nausea, vomiting;
lack of appetite, weight loss;
reduced motor activity.

The use of a pharmacological drug helps to normalize the functioning of the gastrointestinal tract when taken simultaneously with medications that destroy pathogens of intestinal infections. Mezim for bloating in young children is also prescribed after eating fatty and fried foods.

Advice: “Parents should take into account one feature - when giving a child a tablet, it cannot be divided or dissolved in water. The active substance must penetrate the intestines, so the drug shell cannot be damaged.”

Digestive disorders can be treated with Mezim during pregnancy only if you follow a gentle diet.

Compound

If a doctor has prescribed Mezim, the composition of the tablet will help you find out what this drug is and what its principle of operation is. The medicine contains active and auxiliary elements. The main active ingredient is pancreatin, a multienzyme component designed to compensate for the deficiency of exocrine function. Additional ingredients include pancreatin enzymes:

lipase;
amylase;
protease;
trypsin;
chymotrypsin.

The drug Mezim 10000 differs from Mezim 20000 in that the latter includes twice as many active components that can cope with the symptoms faster and more effectively. Mezim 10000 is relevant for the treatment of diseases associated with the function of the gastrointestinal tract; it is used for intestinal infections, stool disorders, and also as an emergency remedy to help digest fatty foods. Mezim 20000 is indicated for chronic pancreatitis and other diseases of the stomach that have entered the chronic stage.

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Composition and action

The drug is produced in tablet form and has three variants. The numbers 10000 and 20000 can be added to the main name. This indicates how many units of lipase are contained in one tablet. The dosage must be prescribed by a doctor, although the medicine is sold in pharmacies without a prescription.

Mezim Forte contains enzymes for the functioning of the pancreas - protease, lipase, amylase. Pancreatin is an active substance of natural origin. They are necessary for better digestion and rapid breakdown of carbohydrates, fats and proteins. The analgesic effect of the drug is due to trypsin, which is also one of the enzymes. It reduces the super-strong secretion of the gland.

By the way! Pancreatin contained in Mezima tablets is protected by a coating that protects the active substance from the aggressive effects of gastric juice. As a result, it reaches the small intestine, where it is released.

When using the drug, improvement occurs within 5-10 minutes. Maximum activity begins half an hour or 45 minutes after consuming the product.

pharmachologic effect

Pancreatin is obtained by extracting pork pancreas. This substance helps digest proteins, fats, and carbohydrates. In this case, the absorption of the digestive enzymes themselves does not occur - they are excreted naturally through the intestines. After taking Mezim forte, the absorption of microelements improves, which allows you to increase important indicators of blood composition. Amylase is effective in the treatment of cystic fibrosis. The enteric coating protects enzymes from the effects of gastric juice, ensuring the lipolytic activity of the drug.

Side effects of Mezim

Despite the high efficiency and safety, if used incorrectly or neglecting precautions, side effects occur:

Allergy.
Nausea.
Changes in the consistency of stool.
Pain and tightness in the epigastric region.

Long-term use of Mezim Forte can cause the following phenomena:

Increased level of urea in the urine (hyperuricosuria).
Increased levels of blood and acid in the urine (hyperuricemia).
When treating cystic fibrosis, the patient often exhibits symptoms of narrowing of the intestinal lumen.

What does it help with?

Mezim Forte is a good remedy that helps the body cope with heavy food during its consumption. The drug compensates for the lack of enzymes, facilitates the absorption of food, and prevents the development of complications due to poor nutrition. The main indications for the use of the drug are:

chronic pancreatitis;
inflammation in the gallbladder, liver and stomach;
cystic fibrosis;
secretory pancreatic insufficiency;
intestinal infectious diseases;
flatulence;
disruption of the digestion process;
problems with stool (diarrhea, constipation).

Composition of the drug

The main active substance in Mezim is pancreatin, which is an enzyme isolated from the pancreas of pigs. The minimum enzyme activity of a medicinal product is:

Amylase - 4.3 thousand euros. pharm. units.
Lipase - 3.5 thousand euros. pharm. units.
Protease - 250 euros. pharm. units.

Auxiliary components in Mezim are:

Sodium starch glycolate.
Colloidal anhydrous silicon dioxide.
Hypromellose.
Talc.
Magnesium stearate.
Azorubic varnish.
Titanium dioxide.
Simethicone emulsion.
Macrogol.
Polyacrylate dispersion.

Instructions for use Mezim forte

The medicine is dispensed without a prescription, however, with long-term use, the dose is determined by the doctor individually. Before taking Mezim, it is recommended that you carefully read the leaflet. The treatment regimen depends on the type and severity of the disease, the number of symptoms. Standard therapy involves:

adults: 1-2 tablets 1-3 times a day;
children aged 12-18 no more than 20,000 IU of lipase per 1 kg of body weight;
for a child under 12 years old – up to 1500 IU per 1 kg of weight.

The tablets are taken orally before meals or during meals. The medicine is drunk whole, without chewing, accompanied by a large volume of water, so as not to destroy the acid-resistant top layer. The treatment course can last from 1 day to several months. If, when diagnosing digestive pathologies, a specialist prescribed replacement therapy with Mezim, the method of administration involves its constant use in accordance with the doses specified by the doctor.

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Directions for use and recommended dosage

Before taking the drug, it is necessary to find out the exact cause of problems with intestinal function; any medication prescription should be performed only by the attending physician.

Instructions for use "Mezim Forte 10000"

Mezim Forte 1000 helps with the following disorders:

Pathological processes in the stomach , dystrophic and inflammatory processes in the soft tissues of the stomach.
Helps treat indigestion , flatulence, loose stools.
Unbalanced diet (diet, overeating, fasting), as well as consumption of fatty or overly spicy foods.
Mezim Forte helps to absorb food after removal of part of the intestine.
For severe pain due to intestinal poisoning, it helps relieve symptoms of obstruction and the development of intestinal infection. Mezim helps cope with pain and bloating.
Before a planned feast , in case of excessive overeating, to facilitate digestion and absorption of solid and heavy foods.
Mezim helps nutrients be absorbed into the intestines.
For heartburn and diarrhea, it compensates for the weakness of secretory function, eliminating the causes of loose stools.
For constipation, Mezim helps produce the necessary components for digesting food. The drug is often prescribed to infants.

Dosage:

If there are no additional doctor's instructions , take 1-2 tablets for difficult-to-digest foods and related problems.
For pathological processes, ulcers, colitis, obstruction, 3-4 tablets once. If necessary, the dose can be increased after consulting with a gastroenterologist.
In this case, the daily dose of lipase in the composition of the medication should not be more than 15,000–20,000 OD.E.F. per kg body weight.

Take mezim during meals, do not chew, do not put under the tongue, swallow whole with a glass of warm water.

Method of use of the drug "Mezim 20000"

The use of the drug is prescribed on a case-by-case basis by the attending physician; it helps in the following cases:

With excessive secretion of the pancreas , dysfunction of the gastrointestinal tract.
Helps relieve disorders of the digestive system during severe pain due to chemotherapy or radiation therapy. Take 2 tablets 2 times a day.
As preparatory measures before an ultrasound scan of the peritoneal and pelvic organs. Take 3 tablets at a time 2-3 hours before the procedure.
Dyspepsia, accompanied by flatulence, nausea, aching pain. Take 1-2 tablets until the symptoms of the disorders stop.
Helps with chronic pancreatitis , Mezim Forte effectively helps relieve symptoms, is used constantly.
For cystic fibrosis, Mezim Forte is an additional therapy drug.
Mezim Forte helps to cope with stagnant processes in the intestines . Take 2 tablets 2 times a day until the unpleasant and uncomfortable symptoms disappear.
Helps effectively with malfunction of the mucous membrane and the development of gastritis. Take 3 tablets per day.

Swallow the medicine whole with plenty of water. Do not exceed the dose; the daily lipase level should be no more than 15,000–20,000 OD.E.F. per 1 kg of body weight. Continue therapy as recommended by a doctor, from 3–5 days to several years for complex diseases.

Instructions for use for children

Mezim is prescribed to a child as a supportive agent for gastrointestinal disorders. A single dose of the medication helps eliminate the consequences of accidental overeating, poisoning or errors in the diet. It is effective for treating children suffering from pancreatitis, diseases of the biliary tract and duodenum. Capsules are prescribed to children according to the following scheme:

1-7 years – ¼ -1 tablet no more than 3 times a day;
7-12 years – 1-2 tablets up to 3 times a day;
12-18 years – up to 20,000 IU of lipase per 1 kg of weight.

The duration of therapy depends on the state of health and ranges from 4 to 30 days. To avoid a decrease in the drug effect, it is better to swallow the capsule whole with a sufficient amount of liquid. Small children can be given the product crushed in water using a plastic syringe. It is not recommended to use enzymes for newborns and babies under 1 year of age.

Patient reviews of this drug

As patients note, the drug is very good and effective. When the first symptoms of dysfunction of the stomach or intestines appear, you can take it once in a therapeutic dose, which helps to quickly eliminate these phenomena. Those who take Mezim systematically also speak very positively about this medication - the drug is accessible, inexpensive and very effective, which are its main characteristics. There are no negative reviews.

True, there are those who tried to replace the product with a cheaper analogue. Patients claim that “Pancreatin” acts in the same way, there is not much difference. Therefore, why overpay for a similar drug?

What Mezim helps with is now known.

During pregnancy and breastfeeding

The instructions for use developed for the drug Mezim allow the medication to be taken during pregnancy. However, doctors advise resorting to treatment only in extreme cases, when the benefits to the mother are higher than the possible risks to the gestating fetus. If side effects occur, you should immediately stop using enzymes. While breastfeeding, drinking enzymes is not prohibited.

Overdose

The symptoms of a drug overdose are unknown and, based on the characteristics of its composition, are unlikely. It can manifest itself exclusively in the form of increased side effects.

It was found that when treated with high doses of drugs whose main active ingredient is pancreatin, patients experienced the development of hyperuricosuria and hyperuricemia. Treatment of overdose symptoms is symptomatic.

What can you combine Mezim tablets with?

Analogs

The pharmaceutical market offers a wide range of enzyme supplements. They are similar in composition, differing only in the amount of amylase and excipients. Medicines in this group are intended to restore digestive processes and maintain the function of the gastrointestinal tract of people leading a sedentary lifestyle, so they should always be in the home medicine cabinet. The main analogues of Mezim include:

Pancreatin;
Festal forte;
Creon 10000;
Gastenorm forte;
Enzistal;
Panzinorm;
Vestal.

Components of the drug Mezim forte and their effect

From the list of enzyme preparations, we need to talk separately about the pancreatin group. And the most famous among them is Mezim Forte. Every person has at least once seen or heard an advertisement about how bad it is to have heaviness in the stomach and about the presence of a magical remedy that makes it possible to digest a whole elephant, at a minimum.

Mezim Forte is an indispensable remedy that helps when the pancreas is not able to cope on its own. This is possible even if there are problems with the pancreas and if the diet is too rich.

Mezim forte 10000 are pink tablets, their color is due to their coating, one tablet contains: Pancreatin with low enzyme intensity:

Lipases – 10,000 units. Ph.Eur . Pancreatic lipase is formed in the pancreas and is also contained in pancreatic juice, then moves to the duodenum. Lipase consists of two components - hydrophobic and hydrophilic and works exclusively at the water-fat interface. It reacts in the cavity of the small intestine - decomposition of food fats, triglycerides into glycerol and higher fatty acids.
Amylase – 7500 U.Ph.Eur. Alfa-amylase is produced in the salivary glands and pancreas. Diastase is produced in the pancreas. This enzyme helps in the process of breaking down starch and various carbohydrates in the duodenum. Amylase is excreted through the kidneys along with urine.
Proteases - 375 IU.Eur. Proteolytic enzymes (i.e. proteases) are proteins, peptide hydrolases, enzymes of the hydrolase class that cleave amide bonds between organic amphoteric compounds in proteins and peptides. Protease plays a very important role in the breakdown of protein foods in our stomach and in the human intestines.

Is Mezim an analogue of the drug Pancreatin and what does the latter consist of? Indeed, it is. Pancreatin is an enzyme digestive medicine that is actually an extract of the contents of the pancreas. It consists of the following enzymes: lipase, amylase, protease.

It is these enzymes that take an active part in the decomposition of fats, carbohydrates and proteins. From time to time, a slight activity of its own enzymes occurs in the stomach; pancreatin compensates for this deficiency, thereby helping to improve the functioning of the gastrointestinal tract.

Price

The drug is an affordable remedy that is effective in the treatment of diseases of the stomach and pancreas. The price of tablets depends on the form of release and the manufacturer.

Mezim release form	forte	10000	20000
10 tab.	95,00
20 tab.	80,00	177,00	340,00
80 tab.	280,00

How to take Mezim

If you take mezim regularly, you can improve the digestion process. This is achieved by increasing and stabilizing the insufficient amount of its own enzymes in the human body.

The medicine is taken before or during meals, one or two tablets. The daily course is two, maybe three times. The tablet must be swallowed with regular still water. An interval of three to four hours should be maintained between doses.

The daily dosage for an adult should be no more than eight tablets (130/150 thousand units); for a child - no more than three tablets, the amount depends on the age of the child. It is not recommended to give the tablet to a child in parts; a one-time dose of one whole tablet is allowed.

The duration of the course depends on the form of the disease and can vary from three to five days to four months.

Analogues of the drug

In case of urgent need (for example, in case of intolerance to the components of the drug), Mezim can be replaced with one of the following analogues:

Creon are enteric capsules that improve digestion processes. Active ingredient: pancreatin. The dosage and course of treatment are selected individually.
Ermital - capsules with medicinal contents, the product replenishes the deficiency of pancreatic enzymes, improves the functions of the gastrointestinal tract, and normalizes digestion processes. Active ingredient: pancreatin.
Pangrol is a gelatin capsule that quickly dissolves in the stomach; the drug promotes the breakdown of proteins, fats and carbohydrates that enter the body with food, thereby improving the functions of the gastrointestinal tract. The active substance is pancreatin.

Mezim is a necessary remedy for children over three years of age with digestive disorders. But to achieve positive results, before using the drug, you must consult a doctor and not exceed the permissible dosage (including taking into account contraindications). This will help avoid side effects and deterioration of the condition in case of existing problems with the gastrointestinal tract.

Is it possible to give Mezim to children? The instructions say that the drug is “used as prescribed by a doctor.” There are no special instructions for young patients. Doctors use the description of the product and the accumulated experience of their colleagues, as well as advice received during advanced training courses.

Mezim is produced from Germany. Its international and trade name is “Mezim Forte”. The drug belongs to the group of enzymatic agents, substitutes for the exocrine properties of the pancreas.

"Mezim" dosage

The medication is available exclusively in tablet form. We can only describe the average dose of this drug, since for each disease the dose is adjusted individually and requires consultation with a specialist
For chronic diseases in adults, the drug is prescribed before each meal, that is, on average up to 4 times a day in an amount of 1 to 3 tablets
When taking the drug, the tablet should not be chewed, but should be washed down with warm water. After taking the tablet, do not take a horizontal position for 5 minutes
If you are taking more than 2 medications at the same time, you should maintain an interval between medications of at least 15 minutes.

Storage and analogues

As analogues of Mezim, you can use products that also contain pancreatin:

The drug "Pangrol" has proven itself quite well. It contains pig pancreatic enzymes. This product is available in capsule form and is contained in a convenient plastic package. “Pangrol” is contraindicated for those people who are allergic to pork meat. Take the capsules whole with plenty of water. Due to the fact that they are quite large in size, children can pour the powder into a spoon and swallow it as quickly as possible, also with water. The product can be stored for twenty-four months at a temperature of about twenty degrees.
The drug "Panzinorm" also contains pork pancreatin. In addition, talc, sorbic acid, polysorbate and gelatin are present as additional components. It is used, just like Mezim, for chronic inflammation of the pancreas, to improve digestion after surgery on the gastrointestinal tract, as well as after acute poisoning.
The fairly well-known drug “Pancreatin”, in addition to the main component of the same name, contains sodium chloride, cellulose, titanium dioxide and propylene glycol. It is taken like Mezim - before or after meals, in the amount of one or two tablets. In case of overdose, diarrhea or intestinal obstruction may occur. Some patients experience nausea accompanied by vomiting. For most patients, Pancreatin is prescribed individually depending on the nature of their disease.

The drug "Mezim" is stored for three years out of the reach of small children and pets. Storage temperature should not exceed twenty-five degrees and fall below ten.

Rules for treating children with Mezim: regimens and dosages by age

Treatment rules differ little from those for adult patients. A more detailed explanation of the conditions will help parents organize therapy together with diet and nutrition.

Effective results from using Mezim Forte can only be expected if the baby knows how to swallow tablets. The doctor counts on this when prescribing the drug to children two to three years old. If the mother manages to lose the situation with the child, then all the contents, thanks to the presence of a protective shell, will certainly enter the intestines and manifest their properties.

The drug should be taken before meals, during meals. With this method of use, enzymes reach the site of action without delay, along with undigested food, and begin restorative work within 2-3 hours.

It is best to take the tablet with warm water, but you can use compote or juice. Do not use milk or hot drinks for drinking.

How long to continue the course of treatment will be determined by the baby’s clinical recovery, cessation of diarrhea and pain, and normalization of stool. After suffering an acute illness, a gradual expansion of the diet usually takes 1-3 months.

The dosage will be prescribed by the doctor. Practice has developed a rule for calculating the weight and age of children.

After administration, the child is recommended to maintain an upright position; the baby should be held in your arms for 5-7 minutes. If you put it in bed, progress through the esophagus and stomach will be delayed, and regurgitation is possible.

For newborns

Let us remind you that by dividing the Mezim tablet into parts, turning it into powder, we destroy the protective shell. How many enzymes will reach the small intestine under such conditions is unknown. At the same time, a dangerous concentration of pancreatin is created in the oral cavity. There is a risk of inflammation and ulcers.

There are no special instructions for treating newborns with Mezim Forte. By allowing a powder to be prepared from a quarter of a tablet and diluted in water, and then injected into the baby’s mouth with a syringe without a needle (if it is not possible to use a teaspoon), the doctor takes responsibility.

Parents should understand that the manufacturer, apparently for good reason, does not produce the drug in drops and does not give direct permission for the treatment of children with the drug.

Children of primary and school age

When using Mezim 10000, the upper standard daily dose for children under 12 years of age is 1500 units. per kg of body weight, at 12-18 years old - 2000 units/kg.

Mezim 20000 is prescribed in a dosage of 1000 units. per kg.

Standard dose of Mezim from 1 year to 7 years: 1 tablet three times a day.

First aid for overeating

If you have an unbalanced diet, Mezim is needed to quickly eliminate discomfort in the solar plexus area.

This problem can be solved in two ways:

Take 1 tablet of Mezim forte on the eve of the feast, and the second during it.
When the feast is already in full swing, and unpleasant symptoms appear, immediately take 1-2 tablets.
If relief does not occur, the total dose can be increased to 4 tablets.

Note! If there is an error in food, 3500 units will be enough.

Pregnancy and breastfeeding period

Pregnant women and mothers breastfeeding their babies should take mezim with caution and only under the supervision of a doctor. Your doctor will give you recommendations for your appointment.

The peculiarity is that if used incorrectly, mezim can immediately affect a newborn baby.

In cases of breastfeeding, you should adhere to a certain diet and rules. Then mezim will be effective for the mother and safe for the child.

You shouldn’t just take mezim unless there are compelling reasons. For example, if a pregnant or lactating woman has cystic fibrosis and inflammatory diseases of the gastrointestinal tract, the doctor will prescribe medicine.

Other cases must be considered separately.

Are there any health risks with uncontrolled use of an enzyme preparation: doctor’s answer

When the drug is taken uncontrolled, negative properties often appear. These include:

allergic reactions to components in the form of itchy rashes, asymmetrical swelling of the face, runny nose, nausea and vomiting, suffocation;
malabsorption of the essential vitamin folic acid.

Hypovitaminosis occurs more often with prolonged use of enzymes. It is expressed:

depressed mood, apathy;
insomnia;
loss of ability to concentrate, memory impairment;
dry skin;
losing weight.

There is an increase in the concentration of uric acid in the blood. The formation of salt stones - urates - is possible in the urine. Allergies require urgent medical attention and discontinuation of the drug.

Harm to the pancreas during long-term treatment with Mezim: fact or fiction?

In enzymology (the science of enzymes) there are scientists who are opposed to the long-term use of any enzyme preparations. They put forward the theory of “lazy pancreas syndrome.” Presumably the condition is caused by suppression of the organ’s own activity with a constant supply of necessary enzymes with medications. The effect is also called “habituation”.

The opinion is justified by the natural need of the organs to independently produce secretions. When replacing medications after some time, all signs of the disease worsen, and an increase in dosage is required. Proponents of the theory believe that artificial enzymes can be used for no longer than a month. At the same time, herbal enzyme preparations are actively promoted as a natural remedy. Among them:

Bromelain - found in pineapples, a natural fat burner, catalyzes carbohydrate and protein metabolism. Covers the lack of pepsin in gastric juice. Prevents excess accumulation of body weight. Recommended to take with meals. Activates peristalsis and elimination of toxins. Supports intestinal microflora.
Papain is an extract of the melon tree (papaya). Contains lysozyme (proteolytic enzyme), capable of destroying toxins and harmful microorganisms. Proteins from food are more easily absorbed in the intestines.

Gastroenterologists do not support the theory; they consider it unproven, and the presence of glandular enzyme deficiency is confirmed by tests. Mezim, like other enzyme preparations, replace temporarily absent biological substances. Without them, impaired digestion turns into negative biochemical processes in vital organs.

The goal of treatment is to achieve stable remission, after which it is proven that the independent functions of the pancreas in producing enzymes are restored. There is no “addictive effect” observed.

What is Mezim used for?

The drug Mezim, given its composition, should be taken for:

condition after resection of the intestine and stomach;
diarrhea;
feeling of discomfort after eating;
bloating;
intestinal infection;
preparation of the gastrointestinal tract for radiological examinations and ultrasound.

It is important to remember that for all indications, the drug should be taken only after consultation with a specialist.

The harm caused by alcohol after using Mezim is obvious. The enzymes contained in the drug break down not only food, but also alcohol. For this reason, a person is unable to feel intoxicated and continues to drink. The “benefits” for the liver are obvious. The result of a person drinking alcohol together with the drug can be the liver working at its limit, and even its failure. The harm that alcohol causes to the body is undeniable. Those taking Mezim simply cannot stop and continue to poison themselves.

Features of the diet during treatment with enzymes

Digestive enzymes help absorb substances in food. For the full therapeutic effect, a diet is required, because even additional enzymes may not be enough if you eat everything. In case of exacerbation, complete fasting is prescribed for 2 days, then liquid mucous porridge. Mezim helps withstand the expansion of the diet.

People with pancreatic diseases need to constantly monitor their diet, cooking methods and amount of food eaten. The number of feedings in small portions should be 5-6 per day; it is forbidden to overeat at night. The diet limits the amount of fats and simple carbohydrates. Everything is prepared only by stewing and boiling.

Here are examples of products harmful to the gland:

carbonated waters (sweet and mineral);
advertised fast food products (convenience foods, chips, French fries);
ice cream and chocolate;
margarine (contains synthetic fats, is included in dough and confectionery products);
strong coffee (especially on an empty stomach);
alcohol in any form;
spices, garlic;
hot sauces, mayonnaise;
sausages;
fatty fish (trout), pork, lamb, duck, including jellied meat, rich broths, jellied dishes;
mushrooms and cabbage in any form.

There are enough healthy foods to formulate a diet. If you drink Mezim as a means of relief, but refuse proper nutrition, a positive result in treatment cannot be achieved.

Indications for use in children

Mezim is prescribed for the treatment of diseases of the digestive tract accompanied by insufficient enzymatic activity of the pancreas. In children, primary and secondary deficiency of pancreatic enzymes are distinguished.

Primary pancreatic insufficiency is caused by congenital pathology of the organ.

Diseases that provoke a complete lack of enzymatic activity or insufficient production of substances include:

aplasia, hypoplasia;
tumors;
lactase deficiency;
cysts;
deformation and congenital anomalies;
fibrosis or sclerosis of tissues;
celiac disease;
genetic defects of the enzymatic apparatus;
cystic fibrosis.

One of the severe pathologies that necessitates the constant use of enzyme replacement therapy is cystic fibrosis. This is a congenital genetic disease, which is accompanied by insufficiency and severe damage to the digestive and respiratory systems.

Every newborn undergoes neonatal screening while still in the maternity hospital, which includes a capillary blood test for cystic fibrosis. Once the diagnosis is confirmed, the baby is prescribed high doses of pancreatin for life. The dosage regimen, the drug, its discontinuation or replacement are determined only by a specialist.

Mezima Forte tablets are also indicated for the development of secondary pancreatic insufficiency, which is accompanied by a temporary deficiency of digestive enzymes.

Such diseases include:

chronic pancreatitis of various origins;
failure of neuroendocrine regulation of the rhythm of production of pancreatic enzymes;
diabetes;
inflammation of the duodenum - duodenitis;
formation of stones in the gland ducts;
irritable bowel syndrome;
diseases of the gallbladder and its ducts;
intestinal infections;
tuberculosis.

The most common cause of the development of symptoms of pancreatic insufficiency (nausea, feeling of heaviness, bowel dysfunction, flatulence) is errors in diet. When consuming fatty, salty, refined foods, adaptive mechanisms are disrupted, leading to disruption of the digestive function of the gland.

Mezim is used for diarrhea in a child, bloating, nausea and vomiting, which are caused by overeating or eating low-quality foods.

Food addiction

Many patients are interested in: when to take Mezim? Before or after food? In fact, there are no strict recommendations. And it’s better to discuss this issue with your doctor. But unlike most drugs that suppress the concentration of hydrochloric acid released into the stomach, Mezim has natural enzymes of animal origin that are involved in the process of digesting food. That is why it is taken before meals so that it can promote the breakdown of fats and carbohydrates.

In the event that there is an acute deficiency in natural enzymes, which happens after surgery on the pancreas or with pathological changes in its tissue, then you simply cannot do without a drug like Mezim. In this case, the daily norm can reach up to fifteen tablets per day. According to the instructions for use, Mezim is consumed both during and before meals. Thus, the drug shell has time to dissolve and release the enzymes located under the shell.

If after eating you feel heaviness in the stomach, then the body should be helped and take another tablet of the drug. That is, you can take Mezim before or after meals, following the recommended dosage, which is no more than two tablets at a time. However, you should not get carried away. In the future, the stomach should completely restore its function.

special instructions

There are no special instructions for the use of Mezim Forte.

Precautionary measures for Mezim Forte 10000 and Mezim 20000

Intestinal obstruction is a known complication in patients with cystic fibrosis , so if symptoms reminiscent of this condition appear, you should be aware of possible intestinal strictures .

The drug contains active enzymes that can damage the oral mucosa, even to the point of ulceration, so the tablets must be swallowed whole without chewing.

Patients with congenital galactose intolerance , lactase deficiency and or impaired absorption of glucose/galactose are contraindicated to take the drug.

There is no need to limit activities related to driving a car or dangerous machinery.

Contraindications

There are not many contraindications to taking this drug. This is an acute form of pancreatitis, hypersensitivity to one of the components of the drug or intestinal obstruction. In acute pancreatitis, the pancreas' own enzymes are released, while their release into the intestinal lumen is difficult. If you still take the enzyme drug, you can get pancreatic necrosis - a life-threatening condition. If severe acute pain occurs in the epigastric region, you should immediately consult a doctor and take only those tablets that are prescribed.

According to the instructions for use of the product, side effects from taking Mezim Forte occur extremely rarely. These are usually allergic reactions. With long-term use, increased excretion of uric acid was occasionally observed.

Contraindications and side effects

There are few contraindications for the use of Mezim by children, but they exist:

pancreatitis in the acute stage;
exacerbation of chronic pancreatitis;
constipation associated with obstructive intestinal obstruction (when there is a mechanical obstruction in the lumen);
hypersensitivity to the food additive E122 and porcine pancreatin.

For pancreatitis, occasional use of Mezim Forte is allowed if the child goes through the stage of restorative dietary nutrition.

The instructions for its use also warn about the side effects of Mezim. For example, the digestive system may experience nausea, abdominal pain, diarrhea, and changes in stool character. Immediate reactions indicating hypersensitivity of the child's body sometimes include rashes on the body, sneezing, bronchospasm, and lacrimation.

Features of taking Mezim (before meals or after, what to drink with it)

In mezim, the active components are hidden in an enteric coating. It was invented for the correct and effective action of mezim enzymes. The shell will begin to dissolve directly in the small intestine, evenly distributing the amount of active enzymes throughout it.

The intestine is the place where the breakdown and digestion of incoming food occurs, and the active absorption of beneficial elements and vitamins through the mucous membrane of the wall. Therefore, the effect of mezim will begin in half an hour.

Mezim of any kind should be taken with meals, swallowed, and washed down with plain water at room temperature in sufficient quantities.

You cannot chew the medicine, otherwise the enzymes will begin to dissolve under the action of salivary lipase directly in the oral cavity. This will lead to the formation of mouth ulcers. Then you will have to treat them.

Storage conditions

To purchase Mezima Forte at a pharmacy, you do not need to take a prescription from a doctor, but the use of such a medicine in childhood should only be done after consulting a specialist. The average price of 20 tablets is about 70 rubles. They should be kept at home at temperatures up to 30 degrees - in a place where the drug cannot be reached by a small child. The shelf life of the medicine is 3 years.

The drug can be stored in a dark and dry place. The temperature should not be more than 25 degrees. Shelf life – 3 years.

Before giving Mezim to children, you should definitely consult a pediatrician. The specialist will conduct an appropriate examination and select the optimal regimen for using the medication. Only in this case will it be possible to cope with violations and prevent negative consequences for health.

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Mezim is an enzyme drug that helps improve digestion. It contains pancreatin with active substances. Doctors prescribe medicine when the patient suffers from insufficiency of the exocrine pancreas, infectious processes in the intestines, and diseases of the gastrointestinal tract.

Also, in preparation for x-rays of the abdominal organs and in the period after radiation therapy, the drug is prescribed. Mezim is also taken for digestive disorders associated with overeating.

Most often, Mezim is taken with meals, with a sufficient amount of liquid.