Grandaxin: what is it prescribed for, patient reviews of its use, analogues

The drug "Grandaxin" is classified as a daytime tranquilizer. In Russia, the product began to be actively used only a few years ago, but has already established itself as an effective remedy. It is used to combat anxiety and suppress signs of depression. The medication is available without a prescription, but it is recommended to start taking it only on the recommendation of a specialist. If for some reason Grandaxin is not suitable for the patient, the doctor should also select analogues for replacement. Pharmacies offer several options for equivalent replacement, each of which has its own positive aspects.

I am depressed! — Take Grandaxin. - And what is it?

As a rule, the reason for getting acquainted with Grandaxin is the experience of stress or, in the case of women, the onset of postmenopause. Why is it prescribed and what group of medications does it belong to? This is a tranquilizer that eliminates autonomic disorders and provides a moderate stimulating effect. Unlike other drugs of the same spectrum, it does not provoke addiction, withdrawal syndrome and does not produce a sedative effect (does not cause drowsiness), but, on the contrary, activates the nervous system. Therefore, it is advisable to take it during the day. This will allow you to do everyday activities (including driving a car), while maintaining vigor and good mood.

It is available in tablets containing 50 mg of tofisopam. It is this active substance from the benzodiazepine family that differs favorably from similar components in that it does not suppress the nervous system. Each tablet contains standard fillers: cellulose, starch, lactose, stearic acid, magnesium stearate, gelatin.

Grandaxin will help you cope with a stressful or shock situation and overcome depression if you start taking it at the first sign of it. If a person is diagnosed with neuropsychic exhaustion of the last degree, then it will no longer produce the desired effect and may even worsen the condition. Therefore, you should drink it only on the recommendation of a doctor.

Grandaxin tablets instructions for use

Grandaxin, also has the international name Tofizopam, in Latin Grandaxin (INN - Tofizopam) is available in the form of flat tablets of 50 mg, with a clear score on one side.

The tablets are white or light gray in color and have virtually no odor. The photo shows that the blisters are packed in a white cardboard box with a blue stripe.

Similar in action can be called: Atarax, Adaptol, Afobazol, Bisoprolol, Betaserc, Gidazepam, Tezepam, Neurol, Relanium, Phenazepam, Stresam, etc.

Sonapax, a stronger one, is prescribed for schizophrenia, reactive psychoses, psychopathological agitation and behavioral disorders, and increased aggressiveness.

When taken together with the drug Teraligen, the pharmacological properties of tranquilizers are enhanced.

When is this tranquilizer prescribed?

Clinical trials and practice have confirmed that indications for the use of Grandaxin are various neurotic disorders. It is prescribed in the following cases:

• for the treatment of prolonged neuroses and mental disorders, which are manifested by symptoms such as depression, anxiety, apathy, obsessive feelings, lethargy;
• with VSD, if it is associated with mental disorders and somatic pathologies, which is accompanied by damage to the nervous system;
• to eliminate withdrawal symptoms (as one of the drugs for the treatment of alcohol and drug addiction), which is manifested by trembling of the limbs, a feeling of fear, impaired coordination of movements, chills, and anxiety;
• for the correction of sensory disturbances that arose after trauma, hormonal imbalance, neurotic diseases;
• for the treatment of heart pain associated with damage to the heart vessels;
• to alleviate the condition of PMS and menopause. If, during hormonal changes, a woman develops emotional and mental disorders: increased tearfulness, irritability, sleep disturbances, memory impairment, decreased concentration and attention;
• if one of the following diseases is detected: somatogenic neurosis, myopathy, myasthenia gravis, neurogenic muscular atrophy.

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Pharmacodynamics and pharmacokinetics

The therapeutic effect on the nervous system begins soon after taking the drug. It is quickly absorbed by the mucous membrane of the digestive organs, and after 2 hours its concentration in the blood reaches its peak. The medicine effectively copes with the manifestations of autonomic disorders and exhibits moderate stimulating activity.

Due to the specifics of the formula, taking Grandaxin has the following advantages:

• when maintaining medicinal dosages, it does not enhance the properties of ethanol;
• does not cause addiction of a physiological or psychological nature;
• after the end of long-term therapy does not provoke withdrawal syndrome in any of its forms;
• can be used to treat patients with myopathy, myasthenia gravis.

The product is completely eliminated from the body, without being deposited or accumulating in the tissues. The half-life of the product is 6-8 hours. Up to 70% is excreted in the urine; the remaining metabolites are excreted in feces.

How and who can it harm?

Contraindications to the use of this tranquilizer apply to:

• children under 14 years of age;
• pregnant women (in the first trimester);
• nursing;
• those suffering from respiratory failure in the stage of decompensation;
• persons who have had attacks of apnea (stopping breathing during sleep);
• those who are hypersensitive to the components of the drug.

In the most exceptional cases, it is prescribed to patients with epilepsy, angle-closure glaucoma, and chronic respiratory distress syndrome.

You must be prepared for the fact that taking the medicine may be accompanied by unwanted reactions:

• skin rashes;
• headache or muscle pain;
• insomnia;
• psychomotor overexcitation;
• nausea;
• bloating, constipation;
• lack of appetite;
• feeling of dryness in the mouth;
• Confusion and respiratory depression occur less frequently.

Important! It is forbidden to use Grandaxin together with Tacrolimus, Cyclosporine, Sirolimus; caution must be taken while simultaneously being treated with analgesics, sleeping pills, other antidepressants, antifungals (Ketonazole, Itraconazole). If you are being treated with this drug, it is not recommended to drink alcohol in any doses, as this reduces the feeling of intoxication and can lead to suffocation and death.

Application and dosage

For adults

The drug is prescribed 50-100 mg 1-3 times a day. Tablets are taken in the first half of the day (before 16:00) to prevent insomnia. The maximum daily dose does not exceed 300 mg. For elderly and senile patients, patients with chronic renal and liver failure, the daily dosage of the drug is reduced by 2 times.

For children

Grandaxin is not prescribed in childhood. According to individual indications, the drug is included in the treatment of neuroses for children over 14 years of age in a daily dosage not exceeding 200 mg.

For pregnant women and during lactation

In the 2nd and 3rd trimester of pregnancy, the drug is prescribed in individual dosages depending on the specifics of the disease, age, and concomitant pathology. When including a drug in therapy, the risk of toxic effects on the fetus is taken into account. Minimum effective daily doses are prescribed in short therapeutic courses according to strict indications.

“The blues are gone!”: reviews from ordinary people and specialists

Grandaxin has earned many positive reviews from patients. People write that it literally normalizes sleep in a matter of days, calms the nerves, relieves symptoms of VSD, but at the same time does not turn a person into a “turtle”. When taken, normal performance is maintained. It helps many women solve their specific problems (postpartum depression and the difficulties of the menopause). But some thought its effect was “weak,” while others were dissatisfied with the “side effects” (most often dry mouth and shortness of breath). Psychiatrists also stand in solidarity with patients. They highly appreciate the therapeutic qualities of Grandaxin.

Some patients call the cost of the drug acceptable, others do not think so. After all, for a package of 20 tablets you will have to pay at least 350 rubles, but adults are prescribed 1-2 tablets. 1-2 r. per day (but not more than 6 tablets per day). That is, a course of treatment will cost approximately 3,150 rubles.

Compound

Tofisopam is the active ingredient of the drug - a benzodiazepine derivative. Its properties differ from other representatives of the group, therefore it is considered atypical. The drug "Grandaxin" 50 contains 50 mg of the main component. Additional substances include lactose, potato starch, gelatin, MCC, talc, stearic acid and magnesium stearate.

What can be used as a replacement?

A synonym for Grandaxin (analogue in composition) is Tofisopam, which is produced in the form of powder or tablets. After consultation with a doctor, you can replace these medications with tranquilizers, which have similar indications but have a different active substance. This is Gidazepam (a daytime anxiolytic medication). It is based on gidazepam, costs less (from 190 rubles for 20 tablets), but can cause lethargy and addiction.

Another analogue is Tazepam; The active ingredient is oxazepam. Its price is from 120 rubles. The medicine can also cause drowsiness and withdrawal symptoms. In addition, it lowers blood pressure, so it is not suitable for those who suffer from hypotension.

Another tranquilizer that helps restore mental balance is Phenibut. It contains gamma-amino-beta-phenylbutyric acid and is available by prescription only. For 20 tablets you will have to pay 130-219 rubles if it was made in Russia, or 315-466 rubles if it was released in Latvia. Doctors warn that it is addictive. It reduces the speed of reactions and causes slowness.

Grandaxin is a good, proven remedy for restoring “nervous health.” This is not an advertised dummy based on herbs and vitamins. But drinking it just like that, at your own peril and risk, is an extremely reckless decision, since the medicine can cause quite severe side reactions. And one more thing: Grandaxin, of course, will temporarily create a state of artificial rest, but will not solve the problem and will not make you stress-resistant. Therefore, learn to respond correctly to life’s difficulties.

Interaction with other drugs

Grandaxin is not prescribed in parallel with cyclosporine, tacrolimus, sirolimus, which leads to an increase in the concentration of tofizopam in the blood and an overdose of the drug. The drug enhances the pharmacological effects of antidepressants, hypnotics, anesthetics, analgesics, and antipsychotics.

Barbiturates, anticonvulsants, alcohol, antacids, cimetidine, and oral contraceptives reduce the activity of tofisopam. Antihypertensive drugs from the group of calcium channel blockers reduce the pharmacological effect of Grandaxin on the body. Benzodiazepine derivatives enhance the anticoagulant effect of warfarin. The inhibitory effect of alcoholic beverages on the brain is reduced when taking the drug.

Restrictions on use

The manufacturer warns in the instructions about existing restrictions on the use of the drug.

The use of an anxiolytic should be avoided if the following factors are present:

• causeless outbursts of aggression, motor restlessness in varying severity, depressive state;
• allergy to the components of the composition;
• disruption of the respiratory system (decompensated type);
• sleep apnea syndrome;
• 1st trimester of pregnancy, while breastfeeding;
• malabsorption of glucose-galactose.

The developers of the drug have identified pathologies for which prescriptions are carried out with caution .

Among the main ones:

• angle-closure glaucoma;
• severe inflammatory damage to the lungs;
• a complex of disorders associated with pathological changes in brain tissue;
• dysfunction of the external respiratory apparatus;
• epilepsy.

Clinical trials

Grandaxin is a unique CNS-active drug that has undergone many clinical trials. The drug does not have a sedative or muscle relaxant effect, and does not impair intellectual and psychomotor activity, unlike other benzodiazepines.

The drug has a mild cognitive-stimulating effect, a powerful drug that is prescribed to reduce autonomic disorders that accompany psychotic and nervous conditions.

Tofisopam does not have an anticonvulsant effect and even in a subtoxic dose does not cause sedation. Subtoxic dosages are potentiated only by barbiturates and ethanol.

The use of a dosage of the active substance in excess of 200 mg/kg in animals caused an effect similar to antipsychotics. When a dose of 10 mg/kg was administered, a normalizing effect on the temporary organization of animal behavior and the prevention of stress dysrhythmia was revealed.

The effectiveness of the drug in neurological practice was revealed during a multicenter study in which clinics from 11 Russian cities took part. The results of the study were based on observation data of 220 patients aged 18-55 years with psychovegetative syndrome (PVS).

The effectiveness of taking Grandaxin in psychovegetative syndrome

The main group of patients (140 people) took Grandaxin tablets in addition to traditional treatment. The control group (80 people) was prescribed standard treatment with vascular and metabolic drugs without the participation of drugs.

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Similar dynamics were observed in the fourth week of therapy. If at the beginning of the course both groups did not differ in the level of anxiety, then by the end of the second and especially the fourth week the degree of anxiety decreased much more than in the control group (they did not take Tofisopam).

The degree of vegetative-vascular dystonia was assessed through a questionnaire, during which subjective and objective disorders in patients were identified. The average indicators of the severity of autonomic disorders in both groups at the beginning of treatment did not differ.

By the end of the second and especially the fourth week, the scores in the first group were much lower than in the control group.

Thus, the use of Grandaxin has significantly improved the condition of patients, normalized autonomic imbalance and improved the quality of life.

To study the sedative and hypnotic properties of the drug, a study was conducted in which 60 conscripts aged 19-25 years with a minimum driving experience of one year participated. The first group of participants took Tofisopam, the second took pills with a placebo effect of a similar appearance, then the groups changed.

During the entire study period, not a single minor accident or accident occurred. Twelve individuals noted that while driving a truck they did not feel any stress and were able to cope with difficulties much more easily.

The study proved that the drug does not have a hypnotic effect, does not affect concentration and reaction, and does not dull reflexes. At the same time, the authors are inclined to the point of view that ideally, driving a car should be done without taking any medications.

Limitations and adverse reactions

The main effect of the drug is manifested in the anxiolytic effect. It helps eliminate feelings of anxiety and fear, reduce emotional stress, anxiety and agitation, both mental and motor.

Tofizopam exhibits vegetative stabilizing properties to a high degree. With him it is expressed to the greatest extent compared to other tranquilizers:

• normalizes sleep - eliminates insomnia, promotes rapid falling asleep;
• restores blood pressure;
• stabilizes heart rate;
• reduces sweating;
• improves the functioning of the gastrointestinal tract, eliminates constipation.

The vegetative stabilizing effect is achieved by establishing a balance between the sympathetic and parasympathetic systems.

The stress-protective effect of Grandaxin protects the central nervous system from the effects of a destructive factor. It gives the patient a state of psychological comfort and provides an adequate assessment of what is happening. Protects against the development of unwanted vegetative-vascular reactions: tachycardia, vascular spasms, destruction of the gastrointestinal mucosa. Eliminates excitement.

Tofizopam has a coronary effect to some extent:

• improves coronary circulation;
• reduces the need for oxygen in the heart muscle;
• normalizes metabolism in cardiac tissues;
• increases the amount of oxygen delivered to the heart.

This ability of Tofizopam is widely used in the treatment of coronary heart disease. The drug stabilizes the functioning of both parts of the autonomic nervous system, and thereby improves the electrical conductivity of the heart muscle.

The psychostimulating effect of the drug helps restore the patient’s mental and physical activity. Helps improve cognitive functions, restores thinking abilities, improves mood. Strengthens the ability to resist the effects of unwanted environmental factors.

Grandaxin is recommended to be included in complex therapy as:

• enhancing the effect of antidepressants;
• to eliminate anxiety and panic attacks that can be triggered by starting to take antidepressant medications;
• in cases where the dosage of antidepressants is insufficient, and increasing it is impossible due to the risk of adverse reactions.

The use of the drug as monotherapy is undesirable.

Contraindications to the use of the drug are:

• severe forms of depression - with them there is a high probability of suicidal thoughts and actions;
• phobias, obsessions - possible increase in aggression;
• allergic reactions;
• uncompensated respiratory failure.

The drug is prescribed with caution to elderly people due to their increased susceptibility to it. It is not recommended to use it at this age for too long a time.

The drug is contraindicated for children under 18 years of age. It can be taken only in rare cases after carefully weighing the need and risks. In this case, therapy should be short-term.

Taking the drug in the 1st trimester of pregnancy is contraindicated. It easily crosses the placental barrier and can cause developmental defects in the child. Grandaxin can pass into breast milk, so you should avoid breastfeeding while treating with the drug.

Otherwise, when it enters the child’s body, it accumulates and causes a sedative effect. The newborn's sucking reflex decreases, he cannot suck out milk fully, and loses weight.

Despite the mild effect of the drug, it still exhibits some side effects:

• headaches, agitation and aggressiveness;
• sleep problems;
• confusion;
• increased frequency of seizures in epileptic patients;
• breathing disorders;
• poor appetite, thirst, digestive problems;
• jaundice;
• muscle hypertonicity, muscle pain;
• allergic manifestations.

In such cases, taking the drug is canceled.

Since tofisopam is a rather specific drug, it, like any tranquilizers, is not without side effects. Considering that the contraindications to Grandaxin are insignificant, negative manifestations are most often associated with violation of the rules for taking the medication. Possible side effects may include the following:

• Headache.
• The appearance of irritability.
• Sleep problems.
• Excessive nervous excitability.
• The appearance of confusion.
• Lack of appetite.
• Dyspeptic disorders.
• Feeling of dry mouth.
• Depression of respiratory function.
• Muscle tension, pain.
• Classic manifestations of allergies are itching, rash, and urticaria.

An overdose of the drug is manifested by disturbances in the activity of the central nervous system. Since women during menopause are especially vulnerable to various kinds of external influences, an overdose can provoke such serious disorders as confusion, breathing problems, vomiting and coma.

Since the drug does not accumulate in the body, such manifestations can occur when taking a large dose of tofisopam at once (more than 50 mg per 1 kilogram of weight). To ensure that the absorption of the drug occurs slowly, activated charcoal is prescribed. And in terminal conditions - the introduction of dopamine, norepinephrine and artificial ventilation.

Reviews from patients who took the drug

With the onset of menopause, life seemed to collapse. Increased irritability and menopausal symptoms made it difficult to do usual activities.

I had to see a doctor. After 2 months of therapy using Grandaxin, I was able to return to my favorite job and improve my general condition (emotional and physical).

Together with my wife we ​​are raising a grandson. After his parents left, he became uncontrollable.

But the most difficult time came when the child reached adolescence. Anxiety disorders prevented him from not only studying, sleeping normally, and performing his duties.

The neurologist prescribed therapy with Grandaxin. It took more than one month to restore the psycho-emotional background of the grandson. But the drug coped with the task.

Efficiency and safety

The therapeutic effect is manifested in eliminating feelings of anxiety and fear, increasing attention, and normalizing sleep.

It should be noted that the latter effect is achieved due to a general improvement in the psycho-emotional state and is not associated with a sedative or hypnotic effect.

Treatment of patients with psychovegetative syndrome according to standard regimens with the addition of vascular and metabolic drugs improves indicators of emotional status (elimination of anxiety and depression). Grandaxin also relieves symptoms of autonomic disorders in severe VSD.

Features of taking the drug

It is worth noting that there is no addiction to the drug: it does not affect reaction speed and attention, so female drivers can take it without fear. To avoid insomnia, it is best to take the tablets in the morning. The specialist will prescribe how long to take the drug based on the patient’s testimony. However, menopause is not a reason to change standard prescriptions, and even vice versa: the doctor can even prolong the use of the medication if necessary.

On average, the daily dose of the drug is 1-2 tablets.

The maximum prescribed dose per day is 300 mg, that is, you can take 6 tablets, however, such doses are prescribed only for severe neuroses of menopausal origin in women. Taking the drug is not associated with eating food, so Grandaxin can be taken even in the morning, before meals, but doctors still advise taking the medication with juice or eating a light breakfast to avoid nausea. If the course of menopause is complicated by alcohol syndrome, tofisopam is prescribed for a long time - for about a month and a half.

Some women note: I forget to take a pill and take two the next day. This is extremely undesirable and even dangerous. If you cannot take the pill in the morning, you should delay taking it rather than take a double dose the next day.

The use of Grandaxin excludes the simultaneous use of alcoholic beverages and other tranquilizers. This can provoke negative consequences and severe reactions of the body: fainting, shortness of breath, serious allergic reactions. If a woman drank alcoholic beverages, the medication increases their toxic effect on the liver, and the effectiveness of Grandaxin is significantly reduced.

Antifungal drugs such as Itraconazole and Ketoconazole enhance the effect of Grandaxin.

The presence of nervous disorders in women during menopause requires immediate treatment. They cannot be ignored, as they can provoke both somatic pathologies and psychological problems. Grandaxin is the mildest drug that can be prescribed at the initial stage of the manifestation of neuroses during menopause.

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Reviews about "Grandaxin"

The response of patients to the drug is in most cases positive. People note a pronounced effect of the medicine in situations where valerian or other herbal products do not bring the desired result. Consumers are also attracted by the rapid appearance of the first signs of favorable dynamics - on average, they appear on the 2-4th day of therapy. As an additional advantage, respondents indicate the ability to continue driving a car without making changes to their usual schedule. Particularly noteworthy are the positive reviews from women who use the product to combat neuroses due to PMS during menopause.

Doctors' attitude towards the drug is also mostly positive. They note that in situations where patients adhere to the regimen chosen personally for them and observe the duration of therapy, a positive effect occurs in 85-90% of cases.

Analogues of "Grandaxin"

The main analogue of the drug is considered to be its synonym under the international non-proprietary name “Tofisopam”. These drugs contain the same active substance and are similar in structure. Among products of the same type of action, doctors distinguish Afobazol, Relanium, Tazepam, Diazepam and a number of other names. It is strictly forbidden to replace them with each other yourself.

Most often, Grandaxin is compared with Afobazol. The products have the same list of indications and fight similar conditions and symptoms. In terms of cost, they are in the same category. At the same time, their active substances are different, which causes a number of differences. In particular, Grandaxin has a milder effect, so it is allowed to be used in the 2-3 trimesters of pregnancy and old age. According to reviews, Afobazole is better tolerated by patients and less likely to cause adverse reactions.

When to use the drug?

The main indication for the use of Grandaxin is neuroses of various origins, including neuroses during menopause. The drug is recommended for the following disorders:

• fears;
• feeling of anxiety;
• nervous tension;
• panic attacks;
• depression;
• alcohol syndrome;
• irritability;
• indifference to what is happening, apathy;
• lethargy, emotional decline;
• post-stress adaptation disorder;
• cases of psychopathy;
• premenstrual syndrome;
• climacteric neuroses;
• neurotic conditions provoked by other pathologies.

The broad capabilities of Grandaxin made it possible to conduct diverse observations of patients during menopause and evaluate its effect on the body.

Alcohol and Grandaxin

Like many tranquilizers, it is not recommended to combine the medication with alcohol. Even a small dose of a low-strength alcoholic drink in combination with a medicine can have negative consequences for the body. The possible adverse effects of these components separately when used in parallel are greatly enhanced. The results can be the most unexpected - from changes in behavior to loss of consciousness or stopping breathing.

Intersecting in the human body, alcohol and the drug can provoke persistent headaches, irritability, insomnia, and allergic manifestations. Such experiments are especially dangerous for people with liver disease and chronic alcoholism. Some people suffering from alcohol addiction try to enhance the “antidepressive” effects of alcohol with the help of tranquilizers. "Grandaxin" is not suitable for obtaining such an effect. Its sedative properties are dulled by ethyl alcohol, leaving only a depressant effect on the nervous system. The result is a worsening depression.

Overdose

The presence of only one dosage form of the drug in a unique concentration, as well as a simple method of administering the drug, minimize the risk of errors during therapy. Even a significant excess of the permissible one-time or daily volume of the drug rarely threatens an overdose. The danger arises when consuming the product in extremely high doses - 50-150 mg per kg of body weight. In this case, the victim vomits, respiratory function is depressed, signs of clouding of consciousness appear, and convulsive seizures are likely. The patient may fall into a coma due to a sharp drop in blood pressure.

Help with this condition should be provided by professionals. Before doctors arrive or if symptoms are mild, it is recommended to rinse the victim’s stomach and give an absorbent to slow down the absorption of the active component of the product into the blood. Most often, activated carbon is used in a volume of 1 tablet for every 10 kg of body weight. Flumazenil, a benzodiazepine antagonist, is used in extreme cases. Its effect on the body in such situations has not been fully studied.

Treatment for an overdose of Grandaxin is symptomatic. Health care workers monitor the patient’s physiological indicators and respond to emerging symptoms. In case of breathing problems, artificial ventilation is performed. To combat hypotension, the patient is placed in the Trendelenburg position and given fluid resuscitation. If the blood pressure does not rise quickly enough or there is no reaction, Dopamine and norepinephrine are used.

How to recognize depression

As already mentioned, the drug helps get rid of depression, but not all of its forms. Grandaxin is taken only for mild to moderate disease with moderately severe symptoms.

During the course of the disease, several syndromes are distinguished:

1. Emotional disorders: low mood, melancholy, anxiety and internal tension, pessimistic attitude; self-flagellation, lack of interest in the world around us, inability to have fun.
2. Behavioral reactions: solitude, reduced activity; bad habits;
3. Cognitive functions: inability to concentrate, slow thinking, decreased memory and perception; pessimistic thoughts, thoughts of suicide, low self-esteem.
4. Autonomic disorders: poor sleep, appetite distortion, weakness and malaise, intestinal dysfunction; discomfort in the heart and other organs, headaches.

A specific indication for the use of the drug is reactive depression. It develops in response to the action of some traumatic factor. The condition is characterized by a consistently reduced emotional background and fixation on the problem.

The patient reproaches and blames himself for what happened, his conversations are aimed only at the problem. And, constantly analyzing it, he seeks support from those around him.

A person is worried about insomnia. And he is fully aware of his condition.

Attacks of despair and demonstrative hysterics are possible. Excitement reaches a state called “melancholic raptus.” At the same time, the person rushes about aimlessly, sobs, screams, and suicide attempts are not ruled out.

This state can be replaced by a depressive stupor, when the patient “freezes” in one position, not reacting to what is happening.

Pharmacological effect

Grandaxin is a benzodiazepine tranquilizer. The main effect is anxiolytic (sedative). Unlike other benzodiazepine tranquilizers, it does not have sedative, hypnotic, muscle relaxant, or anticonvulsant effects.

The medication regulates psycho-vegetatives and relieves various autonomic disorders. Has a moderate stimulating effect. These pharmacological properties determine that the drug belongs to the group of daytime anxiolytics. Due to the lack of a muscle-relaxing effect, the drug can be taken by patients with myasthenia gravis and myopathy.

The atypicality of the chemical formula of Tofisopam, which is very different from the structure of classical benzodiazepine anxiolytics, gives the drug a number of advantages:

• in a therapeutic dose does not enhance the effect of ethanol;
• does not cause withdrawal syndrome;
• does not cause mental or physiological addiction.

The mechanism of action is associated with a stimulating effect on benzodiazepine receptors in the brain. Their excitation leads to an increase in the sensitivity of GABA receptors to the neurotransmitter. As a result, chlorine channels begin to work more efficiently, hyperpolarization of nerve cell membranes increases, and neuronal activity is weakened.

special instructions

Before starting to take the medicine, it is recommended that you read the attached leaflet. One-time or systematic use of the drug is accompanied by a number of special provisions, on compliance with which the effectiveness of treatment and patient safety depend.

Features of using the medication:

• the product cannot be combined with drinking alcoholic beverages in any volume;
• The tablets contain lactose, so if you are intolerant to the substance, it is better to choose an adequate analogue;
• with a history of epilepsy, the active substance of the drug can increase the threshold of the convulsive response;
• old age, kidney or liver disease, mental retardation - points that increase the risk of adverse reactions;
• in case of organic brain lesions and/or signs of depersonalization of the patient, therapy should be carried out with increased caution;
• obsessive states, psychoses, phobias are unofficial contraindications to the use of the medicine. Taking pills against their background helps to increase the level of aggression and provokes the likelihood of developing suicidal tendencies.

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Compliance with the rules for taking medication does not affect the speed of reaction, level of attention, or clarity of the thought process. Carrying out therapy using the product does not impose any restrictions on the patient’s daily life.

Side effects

If dosages and special instructions are followed during therapy, a negative response from the body rarely develops. In most cases, the treatment is well tolerated by patients. If any reactions occur, they usually do not require refusal to continue the course.

The list of possible side effects of Grandaxin includes:

• neurological - sleep disturbance, headache, confusion, increased psychomotor agitation or irritability. Patients with a history of epilepsy are at increased risk of developing seizures;
• dyspeptic – loss of appetite, nausea, dry mouth, flatulence, constipation. In isolated cases, cholestatic jaundice is determined;
• immune - an allergic response in the form of skin itching or rashes;
• respiratory – respiratory depression;
• other side effects are muscle pain, increased tone of individual fibers and their overstrain.

Due to the pharmacological properties of the main component, the product does not provoke drowsiness or lethargy. It can be used by people whose work requires quick reactions. The medicine does not affect the quality of attention and can be taken while driving.

Storage conditions and shelf life

Grandaxin is stored at room temperature; access to the storage area should be limited to children. Shelf life: 5 years.

Tranquilizer Grandaxin - tips and recommendations on News4Health.ru

Life in the modern world is replete with many factors that negatively affect human health. The main ones are poor ecology, questionable quality of food, contaminated drinking water, poor quality medical care, as well as stressful situations and bad habits. Therefore, it is so important to pay attention to regular healing of the body using various methods and means. Be sure to consult a specialist so as not to harm your health!