Diclofenac suppositories - what are they prescribed for, and how to use them correctly?

Diclofenac suppositories are one of six dosage forms of a non-steroidal anti-inflammatory drug. Rectal suppositories are actively used in urology, gynecology, and rheumatology to reduce the severity of pain. Diclofenac suppositories effectively relieve acute and chronic inflammatory processes by suppressing the synthesis of prostaglandins. The drug is included in the therapeutic regimens of patients diagnosed with musculoskeletal disorders to eliminate symptoms and prevent the development of further destructive and degenerative changes. The medicine has a wide list of contraindications and exhibits various side effects. Before using the drug, you should consult with your doctor about the advisability and safety of using rectal suppositories.

Analogs and price

Among the most effective and common analogues of Olfen, doctors identify the following drugs:

• Arthrex;
• Veral;
• Voltaren;
• Voltaren Emulgel;
• Diklak;
• Lipogel;
• Diklo F;
• Diclobene;
• Dicloberl;
• Diclovit;
• Diclogen;
• Diclomax;
• Diclomelan;
• Diclonac;
• Diclonate P;
• Dicloran;
• Diclorium;
• Diclofen;
• Diclofenac;
• Diclofenac potassium;
• Diclofenac sodium;
• Diclofenac retard;
• Diclofenaclong;
• Diclofenacol;
• Diphen;
• Dorosan;
• Naklof;
• Naklofen;
• Naklofen Duo;
• Olfen Depocaps;
• Olfen Rectocaps;
• Ortofen;
• Orthofer;
• Orthoflex;
• Rapten Duo;
• Rapten Rapid;
• Revmavec;
• Revodina retard;
• Remetan;
• Sanfinak;
• SwissJet;
• TabukDi;
• Feloran;
• Feloran retard;
• Flotak.

You can purchase Olfen in Russia in the form of a solution for injection at an average cost of 690 rubles for 5 ampoules.

Analogs

You can replace suppositories with other drugs made on the basis of diclofenac. Analogues include:

• Diclovit;
• Voltaren;
• Dicloberl;
• Dicklosafe.

The doctor may prescribe other NSAIDs made from indomethacin, diclofenac potassium and other substances.

What is better than Voltaren or Diclofenac suppositories?

Voltaren is an original drug, the effectiveness of which has been confirmed by numerous studies. Many patients claim that Voltaren is a more effective medication compared to Diclofenac.

Which is better than Indomethacin or Diclofenac suppositories?

According to doctors and patients, Indomethacin is weaker than Diclofenac, and side effects when using it appear more often. The use of Indomethacin is recommended in cases where Diclofenac is contraindicated.

Description and instructions for the drug Olfen

Olfen is another in a long line of non-steroidal anti-inflammatory drugs. It would take a long time to list analogs of Olfen - these are Voltaren, Ortofen, Dikloberl, Diklak. But it’s easier to name the active component of the drug – diclofenac. This drug is intended for the treatment of inflammatory lesions of the musculoskeletal system, relieving not only inflammation, but also pain.

Olfen is used for:

• Arthrosis;
• Rheumatism;
• Gout;
• Lumbago;
• Edema that occurs after surgical procedures;
• Pain of various types - migraines, colic, algodismenorrhea, and so on;
• Acute infectious processes in ENT practice.

There are many forms of release of Olfen - these are not only tablets, capsules or injection solution, but also rectal capsules that are inserted into the rectum, a patch, and a gel. Oral forms (tablets and capsules) of Olfen should be taken generously and swallowed whole - without dividing or chewing. The instructions for the drug specify that you should drink it before meals - then it will cause less harm to your digestion. The introduction of rectal capsules is no different from the use of suppositories. The only thing is that you can moisten the capsule a little to make it easier to administer. To dissolve the capsule, you need to lie horizontally for about half an hour.

Olfen is contraindicated for:

• Intolerance;
• Diseases of the digestive tract - ulcers, colitis, hepatitis and so on;
• Diseases of the cardiovascular system - bleeding disorders, hemorrhoids, heart failure and so on;
• Pregnancy (especially in the third trimester) and lactation.

Side effects and overdose of Olfen

The active substance of this drug acts systemically, so undesirable effects can occur from any system. Digestion most often suffers, and the condition of the liver may worsen. Bleeding is possible - both internal and external. Sometimes the nervous system suffers.

Patients should periodically check the condition of their blood, monitor the functioning of the heart, kidneys, and so on. If your health deteriorates (other than the underlying disease) during Olfen therapy, consult your doctor.

You cannot overdose on such drugs - this will cause poisoning and dyspepsia. But it can also lead to the development of various unwanted ones. The patient needs gastric lavage and symptomatic therapy.

When a gynecologist prescribes Diclofenac suppositories

In gynecology, diclofenac is prescribed for painful conditions when it is necessary:

• eliminate pain and associated muscle spasms;
• reduce tissue swelling in the inflamed area;
• prevent a general or local increase in body temperature;
• limit the penetration of infection into organs adjacent to inflammation.

Such a “female ambulance” is needed:

1. with painful periods – dysmenorrhea;
2. with inflammation of the ovaries - adnexitis;
3. with cystitis;
4. for hemorrhoids;
5. with cysts of the ovaries, fallopian tubes and other organs;
6. with postoperative pain syndrome;
7. during rehabilitation after a miscarriage or abortion;
8. when there is a threat of formation of adhesions in the appendages.

The pain in such cases is sudden and painful; gynecologists do not recommend enduring it. If there are no contraindications, Diclofenac suppositories quickly and effectively cope with pain and inflammation.

During pregnancy, for pain in the lower back and joints, the drug is prescribed in a minimum dosage only in the second trimester. It must be used with caution, since its reduced blood clotting carries the risk of bleeding and miscarriage or premature birth.

In critical cases, if the danger of the inflammatory process for the mother exceeds the possible harm to the baby, diclofenac is used at a later date.

Breast milk is not protected from the penetration of the drug, so breastfeeding can be continued only with small doses of diclofenac - 50 mg/8 hours, taken orally. If injections or stronger doses are necessary, stop breastfeeding.

We must not forget that diclofenac does not treat gynecological disease. Its use in the case of infections and allergies is justified only as an accompaniment to the main treatment, otherwise the problem threatens to quickly develop or become chronic.

Pharmacological properties

NSAID, phenylacetic acid derivative. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits proteoglycan synthesis in cartilage.

For rheumatic diseases, it reduces pain in the joints at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase range of motion.

For post-traumatic and postoperative inflammation, it helps to quickly relieve spontaneous pain and pain during movement, and also reduces inflammatory swelling.

The drug exhibits an analgesic effect for moderate and severe pain of non-rheumatic origin.

In case of primary dysmenorrhea, Olfen-100 Rektocaps has an analgesic effect.

After administration of Olfen-100 into the rectum, Rectocaps dissolves within a few minutes, absorption occurs more slowly than with other forms of Olfen. Cmax in plasma is achieved 1 hour after administration.

Plasma protein binding is 99.7%. Does not accumulate. Penetrates into synovial fluid. Cmax in synovial fluid is observed 2-4 hours later than in plasma.

Metabolism and excretion

Hydroxyl glucuronide and sulfate metabolites have virtually no biological activity and only about 1% of these substances are excreted unchanged by the kidneys. Biological half-life in plasma occurs within 2 hours and is independent of renal failure. T1/2 from synovial fluid. Systemic clearance of the active substance is approximately 263 ml/min.

Pharmacokinetics in special clinical situations

Pharmacokinetics does not change depending on the age of the patient.

In patients with severe renal dysfunction (creatinine clearance less than 10 ml/min), the proportion of metabolites excreted in bile increases, so no increase in their concentration in the blood is observed.

Pharmacological effect

Diclofenac sodium has a good anti-inflammatory effect, is an excellent analgesic and quickly reduces fever in patients. In addition, Diclofenac helps thin the blood, which reduces the risk of thrombosis. The effect of the drug is due to the inhibition and suppression of the enzyme cyclooxygenase, which is involved in the synthesis of prostanoids. Diclofenac helps reduce the level of mediators of pain and inflammation, significantly reduces the formation of kinins, and has a positive effect on lysosome membranes.

Diclofenac suppositories promote blood flow to the problem area, increase the permeability of the vessel walls, due to which plasma leaves the cells, and the patient’s swelling disappears. For rheumatism, the drug can significantly reduce pain, both at rest and in motion, relieves morning swelling, improves the functioning of joints, combating their stiffness. Diclofenac is also prescribed for migraines to relieve attacks of the disease.

Directions for use and doses

The initial daily dose is 100 mg.

For mild to moderate pain and long-term therapy, a dose of 200 mg/day is usually sufficient. To prevent pain at night and morning stiffness, taking Olfen-100 Rectocaps before bed can be combined with taking Olfen-50 Lactab (up to a maximum daily dose of 150 mg). The course of treatment usually lasts 5-6 weeks.

For primary dysmenorrhea, the daily dose, selected individually, is 200 mg; The initial dose should be 100 mg and, if necessary, can be increased over several menstrual cycles to a maximum of 200 mg. Therapy should begin when the first symptoms appear and continue for several more days, depending on the patient's condition.

Olfen-100 Rectocaps capsules must be administered rectally with a blunt end. To facilitate insertion, they are treated with a lubricant. If necessary, the capsule can be moistened with water before administration. After administration of the drug, the patient should remain in bed for minutes.

"DICLOFENAC": reviews

I became acquainted with this drug during my illness. I was diagnosed with ovarian inflammation and it was accompanied by incredible pain. Treatment began with suppositories, and soon I felt relief. The most important thing is without pain, and the effect came almost immediately. I had to ask for help. I would like to note that it helped me even after the operation, I already took it in tablets. I recommend it.

This drug relieves pain well, and what is especially important, fights its root cause – inflammation. Different forms of release make it possible to choose the appropriate one, depending on the problem - acute pain or the need for course treatment. The extensive base that proves its effectiveness inspires confidence. But you need to be careful, long-term use negatively affects the functioning of the gastrointestinal tract.

In what cases is it prescribed

Diclofenac in the form of suppositories is used for symptomatic therapy. This dosage form is indicated for children and adults in the treatment of diseases in which the temperature rises, the inflammatory process and pain develop in different localizations.

This remedy does not affect the root cause of the disease, so it is not included in etiotropic treatment regimens. Diclofenac suppositories are prescribed for therapeutic purposes when:

• ankylosing spondylitis;
• thrombophlebitis, venous insufficiency;
• tumors of a benign and malignant nature (to relieve acute pain, prevent the progression of metastases);
• post-traumatic, juvenile, psoriatic, gouty and infectious arthritis;
• radiculitis;
• tenosynovitis;
• osteoarthritis;
• bursitis;
• gout

This drug is also prescribed to people during the rehabilitation period after treatment with chemotherapy drugs, after surgery. Candles help reduce the severity of pain and stop the development of inflammation. The medication is prescribed by traumatologists for sprained tendons and ligamentous tissue to relieve swelling.

A non-steroidal anti-inflammatory drug is indicated for viral and bacterial respiratory infections, accompanied by intense pain, if analgesics or other NSAIDs are ineffective.

Suppositories for rectal administration are used in the treatment of migraines. For such pathology, Diclofenac is used only in this dosage form.

Compared to other dosage forms, suppositories do not cause negative reactions to a large extent. The medicine is used for therapeutic purposes in myositis, to stop the inflammatory process in the striated muscles of the musculoskeletal system. The medication is also effective for intercostal neuralgia, hernia, and pinched nerve endings.

Diclofenac suppositories are prescribed to patients for the complex treatment of biliary and renal colic caused by problems with the outflow of biological fluids. This helps to quickly cope with acute pain syndrome.

Use of Diclofenac during pregnancy and lactation

To date, insufficient data have been collected on the possibility of using Diclofenac in pregnant women. The drug is prescribed in the first and second trimesters of pregnancy very rarely, only in situations where a woman cannot do without this drug and the risks to the fetus are negligible. Like any inhibitors of prostaglandin synthesis, Diclofenac is absolutely contraindicated in the third trimester of pregnancy. Taking the drug by a woman during this period of pregnancy can cause the uterus to contract and close the ductus arteriosus in the fetus.

It is not recommended to take Diclofenac while breastfeeding. If a woman needs to be prescribed the drug, she must stop feeding the baby.

Diclofenac, like other non-steroidal anti-inflammatory drugs, should not be taken in preparation for pregnancy. Diclofenac is strictly contraindicated for women who are being treated for infertility.

Restrictions on use and negative reactions

When the suppository is inserted into the anus, the active substance enters the blood without having a negative effect on the intestinal mucosa. Thanks to these properties, Diclofenac in suppositories is prescribed to people with gastritis in remission. However, for some diseases this remedy is contraindicated.

It is not recommended to use this drug if you have:

• bronchial asthma;
• problems with hematopoietic function;
• poor blood clotting, including hemophilia;
• acute peptic ulcer in the stomach and duodenum;
• erosive gastritis.

During lactation, the use of the medicine is strictly prohibited, as it has the ability to overcome biological barriers. The same applies to pregnant women, as well as patients diagnosed with kidney and liver failure, and children under 16 years of age.

If you do not follow medical recommendations, as well as in the presence of intolerance, the following negative reactions may occur:

• nausea;
• paroxysmal vomiting;
• chronic problems with stool in the form of constipation or diarrhea;
• local allergic reaction;
• dizziness.

"DICLOFENAC" (suppositories): analogues

You can replace the medicine with similar drugs based on the same active substance. These include:

Also, according to indications and principle of action, you can purchase diclofenac analogues in suppositories belonging to the same pharmaceutical group:

Instructions for use Olfen Method and dosage

The gel is applied depending on the surface area of ​​the area to be treated. Typically apply 2-4 g of gel (approximately 1-2 cm) per 400-800 square meters. cm skin. The product is applied 3-4 times during the day. Apply to the affected area, but do not rub in. The daily dosage is no more than 15 g. The instructions for Olfen in the form of a gel indicate that it can be used simultaneously with other forms of this drug.

The course of use depends on individual indications and reasons for therapy. Experts recommend checking the feasibility of continuing it after two weeks.

But you cannot use the gel for more than 14 days in a row if there is damage to soft tissues or the presence of rheumatic diseases of soft tissues. For pain caused by arthritis, the course is no longer than 21 days, unless a specialist prescribes otherwise.

If after a week the condition has not improved, it is advisable to stop using the gel and consult a doctor.

If you use the Olfen patch, the instructions for use indicate that it should be applied to the affected area 1-2 times a day. The skin where the product is used must be clean and dry. You cannot pre-lubricate it with cream. You need to apply the patch without stretching it. When used in the area of ​​movable joints, for example, on the elbows, it is advisable to strengthen it with a mesh bandage.

Before hygiene procedures, the patch can be removed and then re-applied.

For children 6–12 years old, it is better to use the medicine in the form of 25 mg tablets with a usual duration of action. Daily dosage – 2 mg/kg. In the presence of juvenile rheumatoid arthritis, it can be increased by another 1 mg/kg. The tablets are taken whole, before meals, without chewing, washed down with water.

Extended-release tablets are taken 100 mg once a day. In the presence of dysmenorrhea and migraine attacks, up to 200 mg per day is prescribed.

In the form intended for internal administration, the maximum daily dosage of the drug is 150 mg. Before administration, you need to dilute the product with 0.9% salt solution or 5% dextrose solution, before adding sodium bicarbonate solution 1 ml of 4.2% solution or 0.5 ml of 8.4%. Depending on the pain, the infusion is carried out over minutes. To prevent postoperative pain, the medicine is administered within minutes at a dosage of mg. Subsequently, the infusion is carried out at a rate of 5 mg/hour until the maximum daily dosage is reached (150 mg).

Intramuscular administration of the drug (single dose of 150 mg) is also acceptable for the treatment of acute conditions or to prevent the exacerbation of a chronic disease. Treatment is then continued with Olfen in forms intended for oral use. The maximum daily dosage is still 150 mg.

Olfen suppositories are used rectally in a dosage of 100 mg at the initial signs of a migraine attack. If necessary, administer the same dose again.

DICLOFENAC suppositories: indications for use

Rectal suppositories are prescribed for:

• inflammatory, degenerative-dystrophic processes in joints and surrounding tissues;
• injuries and after operations;
• polyarthritis;
• Bekhterev's disease;
• atroses;
• spondyloarthrosis;
• neuritis;
• neuralgia (lumbago, sciatica and others);
• gout

Contraindications

According to the instructions for use of diclofenac, rectal suppositories are contraindicated for such diagnoses as:

• erosions, acute and chronic ulcers of the gastrointestinal tract;
• inflammatory process in the intestines (for example, Crohn's disease);
• heart failure grades 3 and 4;

• severe insufficiency of kidney and liver function;
• intolerance to other drugs from the NSAID group, including aspirin, allergy to additional components of suppositories.

• hepatic porphyria;
• bleeding from any internal organ (special attention to those who have suffered a hemorrhagic stroke, bleeding into the membranes of the brain);
• heart failure, fluid retention;
• increased blood pressure that is difficult to respond to drug therapy;
• coronary artery bypass grafting;
• age up to 12 years.
• pregnancy and breastfeeding (exception – vital signs).

When prescribing the drug to a nursing mother, the baby must be weaned and transferred to artificial feeding. With long courses of treatment (more than two weeks), it is necessary to monitor the level of liver enzymes and the condition of the gastrointestinal mucosa.

Side effects

During treatment, regardless of the duration of the course, side effects may appear:

• nausea, vomiting, abdominal pain, digestive disorders;
• increased liver function tests;
• bleeding from the gastrointestinal tract, both from the upper and lower sections;
• dizziness, headaches;
• sleep disorders, sudden mood swings, seizures;
• disorders of perception: taste, vision;
• increased blood pressure, rapid heartbeat, heart pain;
• manifestations of allergies: skin, respiratory, others;
• swelling;
• inhibition of hematopoiesis;
• spasm of the bronchi and bronchioles.

It has been proven in clinical studies that the active component of the suppository increases the risk of myocardial infarction.

Side effects

Since the drug has a systemic effect, the following side effects are possible.

From the gastrointestinal tract:

1. Problems with stool, flatulence;
2. Vomit;
3. Nausea;
4. Stomatitis;
5. Digestive problems;
6. Pain in the abdomen, for example, cramping;
7. Pancreatitis;
8. Anorexia;

If bleeding occurs in the stomach or intestines, hemorrhagic or ulcerative colitis, diclofenac is immediately discontinued.
Liver:

• Increased activity of alanine aminotransferase and aspartate transaminase;
• Jaundice and hepatitis.

CNS:

• Dizziness;
• Paresthesia;
• Pain in the head;
• Problems with cerebral circulation;
• Emotional instability;
• Problems with orientation in space;
• Memory problems;
• Convulsions;
• Fatigue;
• Sleep disorders;

Slightly less common:

1. Problems with vision, hearing;
2. Psychotic reactions;

Kidneys and bladder:

1. Kidney failure;
2. Hematuria;
3. Fluid retention;

Heart, blood vessels:

• Cardalgia;
• Heart rhythm disturbances;
• High blood pressure;
• Agranulocytosis;
• Anemia.

You can also observe all kinds of allergic reactions, including itching, all kinds of rashes and hives, eczema, Quincke's edema, painful sensitivity to light, anaphylactic shock, baldness; Lyell and Stevens-Johnson syndrome.

It is also possible to develop vasculitis and pneumonia, hemorrhoids, abscesses and tissue necrosis (if the drug was administered intramuscularly).

Is there an overdose?

No cases of overdose have been recorded, but if you independently increase the dosage and frequency of administration of suppositories, classic side effects may occur: nausea, vomiting, dizziness, heartburn, tremor of the upper extremities, increased drowsiness. They are short-term in nature and disappear on their own within the first day after discontinuation of therapy.

Increased sleepiness

pharmachologic effect

Characterized by anti-inflammatory and analgesic properties. Diclofenac, part of Olfen 75, suppresses the synthesis of prostaglandins, which are responsible for the development of the inflammatory reaction. Suppresses platelet aggregation. Long-term use of diclofenac hydrochloride contributes to a pronounced sensitizing effect.

When administered orally, it begins to act within an hour. The maximum concentration in plasma is observed after 2 hours. When administered intravenously, the maximum concentration of the substance in plasma is achieved after 10 minutes.

The bioavailability of diclofenac averages 50%. It binds almost completely to proteins in plasma. Penetrates into all tissues and intra-articular fluid. In the synovial fluid, the concentration of the substance 4 hours after administration is higher than that in plasma and remains at a high level for 12 hours.

Diclofenac inhibits platelet aggregation.

About a third of the substance is excreted in metabolized form in the feces. The rest is processed in the tissues and cells of the liver and is excreted in this state through the kidneys. If used correctly in recommended doses, it does not accumulate in tissues.

The active components of the product reduce the pain and stiffness that occurs in the morning. Reduce edema and swelling of joints, improve their functioning. In terms of its anti-inflammatory activity, the drug is much superior to other non-steroidal drugs, for example Butadione, Ibuprofen, Aspirin. Better tolerated than Indomethacin.

Lidocaine has a strong local anesthetic effect. The mechanism of its influence is based on “switching off” the conduction of nerve impulses from pain receptors to the corresponding area of ​​the cerebral cortex. It undergoes hydrolysis in tissues, so its effect ranges from 60 minutes to one and a half hours. With tissue inflammation, the analgesic activity is slightly reduced.

Drug interactions

Before starting therapy with Diclofenac, it is necessary to take into account that the active substance:

• displaces other drugs that bind to blood proteins;
• increases the effectiveness of anticoagulants that are derivatives of coumarin;
• weakens the effect of diuretics and Aspirin.

The combination of other NSAIDs with Diclofenac increases the risk of developing gastrointestinal ulcers and gastrointestinal bleeding.

Diclofenac weakens the effect of diuretics and Aspirin.

Instructions for use

Voltaren rectal suppositories are recommended to be taken according to the following regimen:

• Suppositories 50 mg - twice a day.
• Dosage 100 mg - once a day.

Before administering the suppository, you should empty your intestines. It is recommended to use an enema with warm vegetable oil.

The maximum daily dose should not exceed 150 mg. You cannot use two suppositories at once and cut the suppositories into two halves.

Instructions for use of Voltaren suppositories (100 mg) indicate a prolonged effect of the drug at this dosage.

Before prescribing a drug to treat a patient, the doctor must take into account his weight and concomitant diseases, as well as existing allergic reactions. Treatment is usually prescribed in a course.

How to use suppositories with Voltaren:

• You need to lie on your left side and bend your right leg at the knee.
• The candle should be inserted with the rounded end into the anus.
• Using your finger, insert the candle into the anus with gentle pressure, push it as far as possible. It is recommended to use Vaseline or any fatty cream for easier administration of the suppository.
• You need to lie down for a few minutes. During this time, the candle should dissolve.
• Refrain from bowel movements for at least an hour.
• Wash your hands thoroughly with soap after the procedure.

Suppositories are intended for use in the rectum only.

When using a candle for a child, it is possible that he will have a bowel movement earlier than after 30 minutes. In such cases, it is recommended to introduce another suppository.

It is worth noting that suppositories are most effective at the initial stage of pain syndrome development, and not at an advanced stage. The use of the drug in this form should be as short as possible, as there is a risk of developing local toxicity.

When using Voltaren suppositories, indications for use must be discussed with your doctor.

Pay the specialist’s attention to concomitant diseases and what other medications you are taking. This must be done to avoid overdose or drug incompatibility.

Use in gynecology

Suppositories in gynecology are used when diagnosing inflammation in the pelvic organs in a patient, regardless of its severity, genesis and location. This pathology is almost always accompanied by pain, swelling and tissue hyperemia. A non-steroidal anti-inflammatory drug has a complex effect on the patient’s body, quickly eliminating all clinical manifestations. Rectal suppositories in gynecology are used as a symptomatic remedy for the treatment of the following diseases:

• formed adhesions in the appendages;
• primary and secondary dysmenorrhea (including to reduce the volume of separated blood);
• infectious pathologies provoked by pathogenic bacteria, viruses, pathogenic yeast fungi;
• polycystic disease of the female reproductive system;
• adnexitis.

Diclofenac suppositories are prescribed for ovarian cysts to reduce the intensity of pain caused by the proliferation of cavities with liquid contents. The drug is recommended after a miscarriage or abortion during the rehabilitation period. The instructions for the use of Diclofenac suppositories in gynecology indicate that the drug is prohibited for use during painful periods without prior diagnosis of the pathology. Such symptoms are characteristic of many diseases not related to the reproductive system. You can use NSAIDs after childbirth as prescribed by your doctor if you are not breastfeeding.

Reviews about the use of this dosage form of Diclofenac in gynecology are only positive. If you follow the doctor's dosage recommendations, the analgesic effect occurs within 40-50 minutes after the suppository is inserted into the rectum.

Pharmacodynamic features

The level of binding of the constituent components of Olfen and blood plasma proteins is close to 100%, and the product is also characterized by the ability to penetrate into the synovial fluid. After the patient has received the most effective therapeutic dose of the drug, within 2-4 hours the highest level of Olfen concentration in the blood can be observed. It takes about 5 hours for the half-life of substances to be eliminated from synovial fluid. The highest level of concentration of the main active component in the synovial fluid can be observed after 12 hours.

Partial metabolism of the drug occurs due to glucuronidation and methoxylation, after which active phenolic metabolites are formed. The half-life of the drug will take about 90 minutes. More than half of the components, namely 60%, are excreted from the body through the kidneys in the form of metabolites. Only 1% is excreted unchanged. Everything that remains is excreted during defecation and with bile (in the form of metabolites).

Mechanism of action of Diclofenac

This drug belongs to the non-steroidal group; the properties of the drug include pain relief.

Due to the powerful composition, arachidonic acid is destroyed and the level of synthesis in the mucous membrane and kidneys is reduced.

This drug is most effective for inflammation and rheumatic diseases. Diclofenac helps reduce painful and uncomfortable sensations, morning pain, and relieve swelling.

Suppositories are used in gynecology to eliminate swelling and inflammation of the genital organs; the drug eliminates itching and burning. In therapy, the drug has virtually no effect during the period of bleeding.

The advantage of the drug is that even with prolonged use, the drug does not lose its analgesic properties.

Release form, composition and packaging

Olfen has various release forms. The method of administration and dosage are prescribed by the attending physician depending on the course of the disease and the presence of disorders in the functioning of the thyroid gland. Often the drug is not included in complex therapy.

Patch

The product is produced in the form of a transdermal patch, which is supplied to pharmacies and medical institutions in special bags (5 pieces per pack of thick paper). The patch contains 140 mg of the working substance (diclofenac sodium) and auxiliary components (including menthol).

The product is produced in the form of a transdermal patch, which is supplied to pharmacies and medical institutions in special bags.

Gel

The gel is available in aluminum tubes (50 g each) or glass jars with a roller; it is white in color and has a mint smell. The ointment contains diclofenac and other components: lactic acid, isopropyl alcohol, sodium metabisulfite, hydroxyethylcellulose, di-isopropyl adipate, sterile water.

Candles

Suppositories or rectal capsules are white in color and elongated in shape. They are supplied to medical centers in cardboard packages, each of which contains 10 candles. 1 suppository includes 100 mg of the active ingredient (diclofenac sodium).

Suppositories or rectal capsules are white in color and elongated in shape.

Ampoules

Olfen 75 is most often prescribed for rheumatic diseases. The injection solution is available in dark ampoules, each of which contains 2 ml of clear medicinal liquid. 1 package contains 5 ampoules.

Excipients include acetylcysteine, sodium hydroxide, polyethylene glycol 400, propylene glycol and pure water for injections.

Pills

Tablets are supplied to pharmacies and medical institutions in cardboard packages. Each box contains blisters with 20 white tablets.

Capsules

Olfen 100 - capsules containing the working component, diclofenac sodium and additional components: gelatin, lactose, glycerol trimyristate, microcrystalline cellulose, erythrosine, titanium dioxide, triethyl acetate, silicon, black and red iron oxide, ammonium methacrylate copolymer.

Olfen 100 - capsules containing the working component, diclofenac sodium and additional components.

The capsules are oblong in shape, packaged in blisters and sold in boxes of 20 pieces.

How to use for thyroid disease?

Some endocrinologists prescribe Diclofenac tablets to their patients. For inflammation of the thyroid gland, suppositories are not used. Tablets are prescribed in a dosage of 75-100 mg in a course lasting 4-6 weeks.

To quickly relieve inflammation, you can apply compresses to the thyroid area using Diclofenac ointment.

It is applied in a thin layer. The top of the application area must be covered with film and cotton wool, and the neck should be wrapped in a woolen scarf. The duration of the first application should be 15 minutes. Then gradually increase the time to 1-2 hours. If no problems arise, you can leave the compress on overnight. The duration of such treatment is 8-10 days. To enhance the effect of Diclofenac, you can add Dimexide.

For inflammation of the thyroid gland, suppositories are not used; doctors prescribe Diclofenac tablets.

Composition, release form and packaging

In what form is Olfen produced? Instructions for use and reviews indicate that this product has many different forms. Let's look at them in more detail.

• Gel for external use. The active substance of this medication is diclofenac. It also contains additional components in the form of lactic acid, isopropyl alcohol, hydroxyethylcellulose, di-isopropyl adipate, purified water, sodium metabisulfite and hydroxypropylcellulose. The gel is sold in aluminum tubes or glass bottles with a roller and a protective cap.
• Solution for injection "Olfen 75". Instructions for use (injections are very often prescribed for rheumatic diseases) indicate that the active ingredients of this form are lidocaine hydrochloride and diclofenac sodium. Propylene glycol, acetylcysteine, sodium hydroxide, water for injection and polyethylene glycol 400 are used as additional substances. The solution is sold in dark ampoules of 2 ml.
• Transdermal patch "Olfen". The instructions for use state that the active component of this form is also diclofenac sodium. In addition, auxiliary ingredients are used as impregnation, including menthol. This medicine is sold in paper-aluminum-plastic bags.
• Olfen 100 capsules. The instructions for use indicate that the active ingredient of this product is diclofenac sodium. It also contains excipients in the form of glycerol trimyristate, lactose, gelatin, sodium carboxymethylcellulose microcrystalline cellulose, erythrosine, titanium dioxide, triethyl acetate, MCC, colloidal aqueous silica, ammonium methacrylate copolymer dispersion type B, black iron oxide and iron oxide red

It should also be said that the drug "Olfen", instructions for use of which are contained in a cardboard box along with the medicine, may have other forms of release (for example, suppositories, tablets, dragees and others).

DICLOFENAC": composition:

• The active component is a derivative of phenylacetic acid from the group of non-steroidal anti-inflammatory substances. Relieves pain, reduces the severity of the inflammatory process, lowers body temperature to normal during febrile conditions.
• Additional substances:
• Witepsol is an oil base in which the active substance dissolves well, is well tolerated by patients, melts quickly at body temperature, and perfectly preserves the active component;
• organic solvent propylene glycol, which allows you to mix the base with the active component into a homogeneous mass;
• Aerosil thickener.

Rectal suppositories are available in dosages of 50 or 100 mg. Candles are packaged in special plastic blisters of 10 pieces. The package contains instructions for using diclofenac in suppositories.

Side effect

In some cases, people with hypersensitivity to the components of non-steroidal anti-inflammatory drugs experience rashes on the skin, accompanied by dilation of capillaries, burning and itching.

In addition, the appearance and development of:

• contact dermatitis;
• expansion of capillaries;
• blisters;
• hives;
• Quincke's edema;
• prophylactic reactions (in rare cases).

When the drug is administered intramuscularly during a course of treatment, in some cases the following is observed:

• dizziness;
• discomfort in the esophagus;
• disruption of the functioning of the digestive system;
• nausea and vomiting;
• decreased leukocyte levels;
• anorexia;
• disorientation;
• insomnia and nightmares;
• irritability, aggressive states;
• sudden feeling of heat or cold;
• numbness of the limbs.

For patients suffering from bronchial asthma or allergies, the drug must be used under the strict supervision of the attending physician, since in some cases the treatment leads to the development of bronchospasm.

When using the transdermal patch for a long period, some patients experience side effects. These include kidney or gastrointestinal diseases. However, the risk of developing diseases increases when using the drug in tablet form.

Using capsules may lead to:

• gastritis;
• ulcer;
• lesions of the esophagus;
• constipation;
• bleeding and tarry stools;
• pancreatitis;
• tongue damage;
• narrowing of the opening of the colon;
• development of heart diseases.

Contraindications

The use of Diclofenac suppositories has a number of contraindications, which include:

• age up to 16 years;
• peptic ulcer in a state of exacerbation;
• bronchial asthma;
• the patient's individual intolerance to the active component of the drug or its excipients;
• period of coronary artery bypass surgery;
• renal, heart failure;
• poor blood clotting;
• damage to the mucosa, erosion of the upper digestive tract;
• hemorrhoids;
• gastrointestinal bleeding;
• proctitis;
• colitis;
• hyperkalemia.

The drug should be taken under special medical supervision if the patient suffers from:

1. liver diseases;
2. diabetes mellitus;
3. smoking and alcoholism;
4. coronary heart disease;
5. stomach ulcer;
6. hypertension;
7. Crohn's disease.

Diclofenac is prescribed with particular caution to elderly patients; patients with a weakened body or lack of body weight; patients with anemia and vascular diseases.

Taking Diclofenac is not recommended in combination with simultaneous use of serotonin reuptake inhibitors; non-steroidal anti-inflammatory drugs, glucocorticosteroids; anticoagulants and antiplatelet agents.

Possible side effects when treating prostate adenoma with diclofenac

When treating prostate adenoma with diclofenac, the following side effects may occur:

• dyspeptic: heartburn, flatulence, bloating, nausea, vomiting, short-term stool disorder;
• irritation of the anal skin;
• local bleeding (2-4%);
• bronchospasm;
• eczema, erythema, photosensitivity;
• increased irritability, anxiety, insomnia, fatigue.

To reduce the risk of affecting the gastrointestinal mucosa, the drug Omeprazole, a proton pump inhibitor, is prescribed; it reduces the likelihood of adverse reactions from the gastrointestinal tract. When taken orally, a slight increase in liver enzymes, or drug-induced hepatitis, exacerbation of gastritis or peptic ulcer, as well as blood dysfunction - a decrease in the number of leukocytes and platelets - may also occur.

Interaction with other drugs

Treatment without the supervision of a doctor is very risky, therefore, before using the drug, it is possible only after consultation with a gynecologist or proctologist (depending on the location of the disease).

Therefore, it is very important to take medications carefully:

1. Diclofenac suppositories should be taken with caution together with drugs that are highly hepatoxic.
   Diclofenac suppositories should be taken carefully with drugs that are highly hepatoxic. These drugs primarily include antibiotics and drugs used to treat epilepsy.
2. Plasma concentration increases in the blood when taking drugs together:
   Methotrexate;
3. Cyclosporine;
4. Digoxin, etc.
5. Taking diuretics increases the risk of developing hyperkalemia.
6. The combined use of anticoagulants (urinokinase, alteplase) increases the possibility of bleeding in the abdominal cavity.
7. Cyclosporine, Methotrexate reduces the level of exposure to sleeping pills and increases the likelihood of developing NSAIDs and GCS.
8. Taking acetylsalicylic acid and the active component of Diclofnac reduces the concentration and effectiveness of the latter.
9. Concomitant use of paracetamol increases the likelihood of nephrotoxic effects.
10. The simultaneous use of hypoglycemic drugs may develop hyperglycemia. In this case, strict control and monitoring of blood glucose levels is necessary.
11. Valproic acid, cefatetan and cefamandole increase the likelihood of hypoprothrombinemia.
12. Co-administration of selective inhibitors increases the level of serotonin in the blood and increases the likelihood of bleeding in the gastrointestinal tract.
13. Taking antibacterial drugs increases the likelihood of seizures.
14. Photosensitizing drugs stimulate the action of Diclofenac in UV rays.
15. The simultaneous use of colchicine and ethanol and preparations based on St. John's wort increases the risk of bleeding.
16. Medications, the principle of action of which is based on stopping tubular secretion, increase the level of plasma in the blood, which can increase the toxicity and side effects of Diclofenac.
17. Drugs such as cyclosporine stimulate greater activity of Diclofenac, which, in turn, increases the likelihood of nephrotoxicity.

How can you replace Diclofenac rectal suppositories - table

The price of Diclofenac suppositories is very affordable and varies within 30 rubles. But, if for some reason it is not possible to buy Diclofenac suppositories 50 and 100 mg, you can purchase analogues of the drug, which contain the same active ingredient.

The most popular substitutes: Naklofen, Diclak, Voltaren, Diclomelan.

If there are contraindications to the use of Diclofenac, the drug can be replaced with drugs from the NSAID group that are identical in action. Analogs of Diclofenac:

• Indomethacin;
• Ketonal;
• Buxopan;
• Flexen;
• Artrum;
• Ibuprofen.

Reviews of Diclofenac suppositories from patients are mostly positive. Some note a weak analgesic effect of the drug, but to a greater extent this depends on the chosen dosage. A high positive effect when using Diclofenac suppositories can be achieved only when the product is used according to the instructions and as prescribed by a specialist.

Recently, the pharmacological industry has been producing a large number of products with a similar effect on the human body with a minimum of side effects. In addition, such drugs can be much cheaper.

special instructions

1. When taking the drug for more than 2 weeks, monitoring of liver enzymes is necessary.
2. Chronic diseases may worsen during treatment.
3. In case of liver diseases, use is canceled.
4. The medicine negatively affects female fertility.
5. Elderly people need to choose the minimum effective dosage.
6. When taking all forms of the drug, except for the gel, you should avoid driving vehicles and operating machinery.
7. The gel should not be applied to open wounds, damaged skin, or under occlusive dressings. After using it, you should wash your hands thoroughly, avoid contact with eyes and mucous membranes, and do not be exposed to direct sunlight.

How to remove Diclofenac from the body

To remove Diclofenac from the body, you need to do a gastric lavage and take activated charcoal. To do this, you can artificially induce vomiting after taking a weakly concentrated solution of potassium permanganate. If the person is unconscious, then a probe is used and gastric contents are suctioned.

Sorbents, such as activated carbon, cause a decrease in gastric contents, which reduces the flow of the drug into the blood. But it is almost impossible to remove the medicine from plasma: Diclofenac binds to albumin, so forced diuresis and hemodialysis are ineffective.

Diclofenac in tablets and capsules: when and how to take?

Treatment of lumbar osteochondrosis with tablets is important in the early stages of the disease: for pain of mild or moderate intensity. Their use in the first stages of the development of the disease makes it possible to slow down its course and prevent the spread of degenerative processes to healthy tissue. In the later stages of osteochondrosis, Diclofenac tablets are prescribed to relieve its main symptoms.

During treatment with the drug, it is necessary to completely abandon bad habits (smoking, drinking alcohol). It is also recommended to refrain from driving a vehicle: Diclofenac reduces the level of attention and concentration, worsens motor reactions.

Since the drug irritates the gastrointestinal tract, it is taken half an hour before or after a meal (but no later than an hour), washed down with plenty of water. In order to prevent the formation of ulcers and bleeding, the doctor additionally prescribes taking medications that protect the gastric mucosa (Almagel, Omeprazole, Phosphalugel).

The dosage of Diclofenac depends on the age and well-being of the patient. Children from 6 to 11 years old are recommended to take one tablet per day, adults - twice as much. The optimal dose and frequency of administration are determined by the doctor based on the individual characteristics of the patient’s body, the stage of osteochondrosis and the likelihood of complications.

In general, for the treatment of the lumbar spine, tablets can be prescribed: fast or long-acting (contraindicated in children under 18 years of age). In the second case, the effect of taking the medicine occurs later, but lasts longer.

Diclofenac tablets help eliminate the symptoms of osteochondrosis, which interfere with complex therapeutic therapy. They relieve inflammation and swelling well and reduce pain. But compared to injections, tablets are less effective and can cause side effects (headaches, allergic reactions, upset stomach, drowsiness). Therefore, treating osteochondrosis with a non-steroidal anti-inflammatory drug in this form without consulting a doctor is unacceptable.

Analogues of the product and reviews

The medicine has analogues. Often doctors prescribe the drug Diclovit or Ortofen in the form of suppositories

.
The products have the same side effects, contraindications, and instructions for use
. The cardboard package includes 10 candles. They can be purchased for 70 rubles.

Diclofenac has a huge number of reviews. Patients consider this remedy effective, time-tested and affordable.

For inflammation of the appendages, my attending physician prescribed Diclofenac suppositories. They were part of complex therapy

.
Thanks to the use of suppositories, it was possible to relieve pain in a short time
.
After the first use, the discomfort disappeared
. Within a week I managed to overcome the illness.

Olga

I had pain in the lower abdomen, like during menstruation. However, my period ended a week ago

.
After the examination, it turned out that I had an inflammatory process in the appendages. The doctor prescribed Diclofenac
.
To my disappointment, it did not work and the desired effect did not occur
. I started using Naklofen suppositories, which got me back on my feet in a couple of days.

Elena

A week ago I started having pain in my lower abdomen. They were so strong that I simply could not straighten up. My gynecologist prescribed Diclofenac rectal suppositories

.
This product literally saved me. It relieved the inflammatory process and painful sensations
. The cost of the medicine is affordable, and the product is highly effective.

Yana

I started using these suppositories after surgery. I am very glad that they are able to relieve pain well

.
The effect of their use can be noticed after five minutes. Some of the side effects I experienced were nausea and stomach pain
. Their activity can be observed for 8 hours. Before using Diclofenac suppositories in gynecology, the instructions for use must be carefully studied.

Alice

Types of suppositories

A variety of candles are available for the back.

They are classified according to the nature of their impact as follows:

1. non-steroidal anti-inflammatory drugs;
2. painkillers;
3. hormonal;
4. chondroprotectors.

Each of them is presented in the pharmacy with its own names, of which there are quite a lot. Now do you understand why you can’t self-medicate? You may misunderstand this diversity and prescribe the wrong suppositories for yourself. By the way, what helped your relative may not be an effective remedy for you.

Detailed description

Diclofenac is a drug on the vital list.
Created in 1966, it has long been used to treat rheumatism. Having a pronounced anti-inflammatory effect and analgesic effect, it was widely prescribed to patients suffering from varieties of this disease. Today, in the instructions for use you can see indications for gynecology, neurology, surgery, oncology and other areas. The main active ingredient is diclofenac sodium. In addition to the above properties, it has antipyretic and analgesic effects. Having a number of positive qualities, it is not indicated for long-term use. A large number of side effects limit the duration of its use.

Terzhinan is a vaginal tablet that contains:

• ternidazole,
• neomycin,
• nystatin,
• sodium metasulfobenzoate,
• prednisolone.

Each component has a certain powerful anti-inflammatory, anti-allergic, and anti-exudative effect. Such vaginal tablets are prescribed for vaginitis of various natures, for vaginal trichomoniasis, and as a prophylaxis for urogenital infections. Use before bedtime.

Antifungal suppositories Polygynax are primarily used in the treatment of gynecological pathologies. Combined action drug. Includes:

• antibiotic polymyxin B;
• antibiotic neomycin.

The product destroys microbes, fungal infections, and pathogenic microflora. Localizes and paralyzes all activity of pathogenic microorganisms, while destroying their membrane. The suppositories themselves are light, soft in consistency, oval in shape with a beige tint.

Has a powerful disinfectant and antiseptic effect. Copes with viruses, fungal infections and other types of pathogens of pathological infections. After vaginal insertion of the suppository, the active substance is released; when it breaks down, iodine is released, which destroys all pathogens, viruses, and fungi. Iodine cells penetrate shallowly into tissues, but due to its slow release, the therapeutic effect lasts for quite a long time.

How to help yourself with back and joint pain

Articles (13525) - Karpov Vyacheslav, 06.09. G.

How can you help yourself with back and joint pain? What is a gentle regime for the spine, what types of painkillers are there, what are non-steroidal anti-inflammatory drugs (NSAIDs), what is better and of higher quality from NSAIDs, the subtleties of pain relief, what is encrypted on the packaging of the products. There are simple secrets that everyone who has been plagued by pain in life should know. With this knowledge, life will become easier, more joyful, and more things will be done.

Gentle regime for the spine:

• Back pain is increased by both frequent changes in body position (bend - straighten, sit - stand every 5-10 minutes), and prolonged stay (2 hours or more) in one position, sitting, lying, standing, etc. .;
• at your workplace, arrange a comfortable chair or armchair;
• clothes for every day should be fairly loose, soft and not restrict movement. Fatigue quickly sets in in tight and rigid clothing;
• alas, stiletto heels will have to be reserved for special occasions. For every day - comfortable shoes with low, stable heels, especially if you have to walk;
• Get a bag with wheels so you don’t have to carry weights on your long-suffering hump. Heavy briefcases and bags with a shoulder strap are the enemies of a sore spine. They create an uneven load on the spine and increase pain;
• You should leave only what you need in your handbag. In no case should it be a weight hanging on you;
• If you still had to drag a heavy bag, try to press it closer to your body, so the load is more evenly distributed along the spine.

Go away the pain, go away the disease

Three pillars of improving well-being, and with it the quality of life in diseases of the joints and spine: pain relief, reduction of inflammation and swelling. Nonsteroidal anti-inflammatory drugs (NSAIDs)

exactly what is needed in this case. In addition, NSAIDs are sold freely in pharmacies without a prescription and are not addictive. No wonder they are so popular. But there is a fly in the ointment. Not all NSAIDs are friendly to the gastrointestinal tract.

The champion in pain relief among all the variety of NSAIDs is ketans (ketorol, ketoralac). He is quite loyal to the stomach. Ketonal is not far behind it in terms of pain relief. However, you can take no more than two capsules or one injection per day. Average rating for pain relief for ibuprofen, nimesil (nimesulide), diclofenac (diclonate, dicloberl, voltaren, etc.). Indomethacin has a slightly lower rating. Ibuprofen is not a friend to the stomach, but it is not an enemy either. It is not particularly hostile to the stomach and does not mix. Aspirin has the least pain-relieving effect and it hits the stomach mercilessly.

In terms of anti-inflammatory effect, indomethacin and diclofenac

. Average rating for ibuprofen, for

they are followed by Ketanov, Nimesil. Aspirin is of little use in anti-inflammatory terms, but it relieves fever well.

Pills, injections, suppositories: which is better?

Intramuscular administration of NSAIDs allows you to quickly relieve pain within 10-20 minutes. When using tablets or capsules, you have to wait longer for pain relief, sometimes 1-2 hours. A more pronounced analgesic effect occurs if you take the tablet before meals. Suppositories can significantly reduce the negative effect of NSAIDs on the stomach and relieve pain within 20-30 minutes.

What is encrypted on the package?

The prefix to the name of the drug retard (Dicloberl retard) means that the analgesic effect lasts a long time and it is possible to take the drug once a day. But pain relief does not come so quickly.

Rapid attachment (Voltaren Rapid) - this form is convenient when you need to quickly relieve pain

. Pain relief occurs within 10-15 minutes after taking the tablet.

• For severe pain, take a pain reliever when the pain is not yet at its peak. The effectiveness of the pain reliever in this case will be higher;
• if severe pain is your obsessive companion, keep painkillers always at hand. If the pain takes you by surprise and gets worse, it can really unsettle you.

Prescription of Diclofenac

The variety of gynecological pathologies requires careful diagnosis. In each specific case, the use of additional means to help relieve pain is considered. A number of reasons contribute to the choice of Diclofenac suppositories in gynecology:

• The therapeutic effect occurs an hour after administration of the suppository;
• Side effects do not cause serious consequences, which does not apply to tablets and injections. For example, tablets are absorbed into the gastrointestinal tract quite quickly. But reaching the zone of inflammation, the active substance decreases in concentration, and the action is noticeably inhibited;
• Rectal suppositories completely deliver the active substance to the disease area.
• If it happens that you cannot take other medications with Diclofenac tablets, then you can with suppositories. This is a good replacement for Diclofenac injections and tablets.

Diclofenac is one of the available medications. There is no difficulty in purchasing it, because it is sold in pharmacies without a doctor’s prescription.

.
But it is wrong to carry out therapeutic therapy without first consulting a gynecologist. It is necessary to treat a specific pathology, which will be announced by the doctor based on the tests taken
. A drug of any dosage form is selected for it, and the dosage is recommended.

If we are talking about suppositories, then the daily dose should not exceed 150 mg of the active substance. The doctor will focus on the contraindications of Diclofenac, making sure that you do not have concomitant pathologies for which taking Diclofenac suppositories is prohibited

.
Rectal suppositories are not an independent medicine that can suppress the cause of the pathology and cure it
. They are used in a complex of therapeutic therapy.

Diclofenac rectal suppositories have the advantage of relieving pain in a short time. In addition, they enhance the protective function of the immune system.

Side effects of Diclofenac in the form of suppositories are less negative than in injections and tablets. It practically does not reach the liver, kidneys, stomach

. But he is not able to eliminate all side negatives. But, as we know, not all side effects occur in the patient.

Analogues of the drug

Diclofenac for prostatitis may not be allowed for all patients. In this case, the question of selecting a suitable replacement for it becomes relevant.

In pharmacies, suppositories for the treatment of prostatitis can be purchased for an average of 100 rubles. This is one of the budget funds that shows a good effect in combating inflammation in the prostate gland.

Diclofenac cannot be taken for a long time; moreover, it has a number of contraindications and side effects. For those for whom this product is not suitable, you can choose any of the analogues:

1. Maloxicam (injections);
2. Nimesulide tablets;
3. Movalis tablets.

If Diclofenac is not suitable, then other suppositories for prostate inflammation are selected. They may contain a similar active ingredient, or another component - in this case, the drugs are similar in their therapeutic effect.

Metamizole is an analogue of Diclofenac in terms of therapeutic results. It has analgesic, antipyretic and anti-inflammatory properties. The mechanism of action of the drug is similar to the effects of other anti-inflammatory drugs. Suppositories for prostatitis are prescribed in a dosage of 250 to 500 mg per day, the frequency of use is 2-3 times a day.

Indomethacin can replace Diclofenac against the background of prostatitis. The main active ingredient is the same name of the drug. Contraindications for use:

1. Bronchial asthma.
2. Acute rhinitis and a history of urticaria caused by NSAIDs.
3. Ulcerative lesions of the gastrointestinal tract.
4. Internal bleeding.
5. Blood clotting disorder.
6. Ulcerative colitis.
7. Organic drug intolerance.
8. Crohn's disease, etc.
9. Hemorrhoidal disease, bleeding from the rectum, rectal fissures.

To stop the inflammatory process, it is recommended to administer three suppositories per day - the total dosage is 150 mg. One-time use of the drug is allowed - a suppository with a dose of 100 mg is administered. You cannot combine the medicine with antacids, since the absorption of the active component is significantly reduced.

You can supplement the list of analogues with other anti-inflammatory suppositories - Naproxen, Movalis, Voltaren, Clofezon and other medications. The dosage is determined individually, as is the duration of treatment. On average, the course lasts 14-28 days. In most cases, several drugs of different release forms are combined. For example, tablets for oral administration and suppositories - the complex effect helps to quickly get rid of negative symptoms.

Diclofenac works quite quickly - the pain subsides 40-50 minutes after administration. Reviews are favorable, since side effects develop relatively rarely, which indicates good tolerability.

Pain Relieving Suppositories for Lower Back Pain

Voltaren suppositories for prostatitis. Indomethacin suppositories instructions. Photo.

Voltaren suppositories for prostatitis can have an anti-inflammatory and analgesic effect on the prostate.

Voltaren suppositories for prostatitis.

Indomethacin suppositories have antipyretic, anti-inflammatory and analgesic effects on the prostate. Rectal suppositories with indomethacin are prescribed for exacerbation of chronic prostatitis.

From the rectum, painkillers quickly migrate into the bloodstream, guaranteeing the fastest and most lasting therapeutic effect.

Indomethacin suppositories instructions.

Lower back pain, what to do? The causes of lower back pain, which specialist to contact, you will learn all this from our section.

In this section, we tried to collect the most common video about lower back pain. Seeing a doctor in a timely manner will make life easier for you and your loved ones.

Painkiller injections for back pain

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How to exercise for lower back pain

5 Paul Bragg exercises for back pain. What exercises should you do if you have a herniated disc? Rehabilitation gymnastics. Photo. 5 exercises.

Hyperextension for Low Back Pain

Hyperextension Special type, Exercise for Biceps HIPS, Gluteal MUSCLES, LOWER and BACK. Hyperextension exercise for back pain. Photo. At the beginning up to 5 minutes.

Injections for Lower Back Pain

Treatment of back pain. How to cure back pain without drugs or surgery. Bio-sticker for the body Shexiang No. 1 (with musk) Pain reliever. Photo. Exercises for pain.

Massage for lower back pain

Massage for back pain and scoliosis. 08 Massage for acute lower back pain Rubbing and vibration. Photo. Massage for pain.

Painkillers for the formation of a hernia in the spine

Unpleasant discomfort in the back can be caused by growths between the vertebrae. This phenomenon occurs as a consequence of advanced osteochondrosis, radiculitis. Hernias cause severe back pain when turning or bending the body, walking, and even at rest. You need to know which pills to take in case of such symptoms.

Treatment for a hernia includes taking painkillers. Among the most gentle medications are Diclofenac tablets and injections. It has minor contraindications, unlike other non-steroidal drugs.

Also, during the treatment of intervertebral disc herniation, muscle relaxants (Mydocalm, Sirdalud) are widely used. They block nervous system signals in damaged fibers, thereby relaxing the back muscles.

It is worth noting that treatment of a hernia is only possible through surgery. Painkillers are prescribed to relieve discomfort before surgery, as well as to eliminate back pain during the rehabilitation period.

Which is safer to take?

Among nonsteroidal anti-inflammatory drugs, there are safer analogues than Diclofenac. Meloxicam is considered one of the safest. It is characterized by high selectivity and low risk of side effects. It is prescribed for the same indications as Diclofenac.

Also, coxibs, a group of anti-inflammatory drugs with a special structure: Celecoxib, Etoricoxib, Rofecoxib, have a selective, that is, selective effect on inflammation. They cause fewer complications than Diclofenac and are the latest generation drugs. They can also be taken over a longer course.

For severe pain, the drug Xefocam helps well. At a relatively small dose, it has a pronounced effect, allowing you to avoid the development of adverse reactions.

For long-term treatment, Ibuprofen is suitable, which is used in rheumatology in extended courses. Paracetamol also has a good analgesic and antipyretic effect with a high safety profile.

We recommend reading about what form to take Diclofenac for hemorrhoids. From the article you will learn about how Diclofenac helps with hemorrhoids, how to use suppositories, ointments and tablets, and whether it is possible during pregnancy. And here is more information about how Diclofenac will help with osteochondrosis.

Diclofenac is often used for inflammation of various origins and has gained great popularity among patients, but it can have a negative and even fatal effect. The risk of adverse reactions depends on the dose and body condition. Before prescribing, you should consult your doctor to avoid side effects.

The principle of action of the drug Diclofenac for prostatitis

The drug Diclofenac for prostatitis acts on the enzyme cyclooxygenase, reducing the production of proinflammatory cytokines. It also affects the condition of smooth muscles, reducing their spasm and swelling of surrounding tissues.

The active substance also affects blood cells: it reduces the migration of immune cells responsible for inflammation and helps reduce aggregation, that is, the sticking of platelets. This improves blood supply to the gland, which helps reduce the accumulation of toxic products of the inflammatory process that damage gland tissue.

Along the urinary tract that passes through this organ, the passage of urine is restored, pain caused by swelling and compression of the organ and ureters is reduced. In the long term, the prostate gland normalizes its function in such conditions.

The principle of action of the drug Diclofenac

Effective anti-inflammatory agents for joints

In the treatment of almost all diseases of the musculoskeletal system of the human body, anti-inflammatory ointments for joints and other dosage forms for systemic administration are used. Due to their high demand, new drugs are constantly appearing on the pharmaceutical market. Not only every doctor, but also the common man, who is often left alone with his problem, must navigate them.

The most important criterion by which anti-inflammatory drugs for the treatment of joints are classified is their division into hormonal (steroidal or glucocorticoid) and non-hormonal (non-steroidal). This is fundamentally important, since the first, in addition to the anti-inflammatory effect, have hormonal activity, which the second group of drugs lacks. The approximate classification and the most common anti-inflammatory drugs for the treatment of joint pathologies are shown in the table.

Important to remember! Only a doctor should select anti-inflammatory drugs for the treatment of joint pathology, taking into account the stage and severity of the inflammatory process. This is especially true in the case of chronic diseases that require long-term treatment!

The first step of the treatment process for all types of joint pathology is the appointment of correct anti-inflammatory therapy and pain relief. Anti-inflammatory drugs from the non-steroidal group are used as first-line drugs. Since their range is extremely wide, the choice of dosage form, dose, method and frequency of administration must be approached taking into account the type of pathological process, the patient’s concomitant diseases, medicinal properties and possible side effects of specific drugs. Most attention is paid to the selectivity of the non-steroidal drug with respect to the mechanism of anti-inflammatory action.

The thing is that NSAIDs act by blocking the enzyme cyclooxygenase (COX), which is responsible for triggering the synthesis of inflammatory mediators (substances that trigger and maintain the inflammatory process). The human body produces two types of cyclooxygenase: COX-1 and COX-2. The second type is produced exclusively at the site of inflammation.

The first, in addition to maintaining the pathological process, catalyzes the reactions of the synthesis of protective mucus in the stomach. Older generations of NSAIDs act equally on both types of enzyme. Against the backdrop of their uncontrolled use, a large number of side effects began to be recorded. The new generations created are characterized by a selective effect on COX-2.

When used in combination, the drug increases plasma concentrations of lithium and digoxin.

Diclofenac sodium reduces the effectiveness of diuretics and increases the risk of hyperkalemia when used in combination with potassium-sparing diuretics.

When using the drug simultaneously with other drugs from the group of non-narcotic analgesics, as well as with glucocorticosteroids, the risk of developing side effects increases.

If it is necessary to use the drug simultaneously with anticoagulants, the prothrombin time should be regularly monitored.

The drug has virtually no effect on the effectiveness of hypoglycemic agents, but there is evidence of the development of hypoglycemia and hyperglycemia in patients taking diclofenac sodium in combination with hypoglycemic agents.

When used in combination, the drug increases the nephrotoxicity of cyclosporine and the toxic effects of methotrexate; an interval of at least 24 hours must be maintained between taking diclofenac and methotrexate.

When the drug is used in combination with quinolones, seizures are likely to develop.

With simultaneous use of diclofenac with lithium or digoxin preparations, it is possible to increase the concentrations of lithium and digoxin in the blood plasma.

Olfen™-100 Rectocaps may reduce the effectiveness of diuretics. When used simultaneously with potassium-sparing diuretics, hyperkalemia may develop (regular monitoring of serum potassium levels is necessary).

With simultaneous use of other NSAIDs or corticosteroids for systemic use, the risk of gastrointestinal bleeding may increase.

Olfen™-100 Rectocaps does not interact with anticoagulants. However, if simultaneous use is necessary, blood coagulation parameters should be monitored as a precaution to assess the development of an anticoagulant effect. Diclofenac sodium at a high dose (200 mg) can reversibly inhibit platelet aggregation.

Olfen™-100 Rectocaps can be used in conjunction with oral hypoglycemic agents, and no drug interactions are observed. In some cases, hypoglycemic and hyperglycemic reactions are possible after using the drug Olfen™-100 Rectocaps, which requires adjustment of its dose or the dose of hypoglycemic agents.

NSAIDs should be used with caution within 24 hours before or after treatment with methotrexate, since the concentration of methotrexate in the blood and its toxicity may increase.

When used simultaneously with Olfen™-100 Rectocaps, the nephrotoxicity of cyclosporine may increase.

What is Olfen? The instructions for use position this medicine as an effective analgesic anti-inflammatory agent. It belongs to the group of NSAIDs and is quite popular among doctors and patients. "Olfen" is a medication designed to eliminate severe pain, relieve an increasing inflammatory process, and, if necessary, reduce body temperature.

Use for cystitis

Diclofenac is often used for the treatment and prevention of cystitis, and suppositories are also very effective in the treatment of other urological diseases. In this case, the drug completely restores the mucous membrane of the bladder.

They must be used strictly according to the instructions:

1. During cystitis, it is necessary to administer 1 suppository 2 times a day.
2. Remove the packaging from the suppository and insert it into the rectum.
3. The organ from the urine is first required.
4. It is allowed to insert no more than 3 suppositories into knocks for medicinal purposes.
5. The course of treatment for cystitis using the drug "Diclofenac" should be no more than 7 days. If the condition has not changed, you need to consult a doctor, get tested, and undergo an examination.
6. The active component of the drug Diclofenac dissolves in the human body within 30 minutes, but is excreted only after 4 hours.

What kind of drug is this?

Diclofenac belongs to the group of non-steroidal anti-inflammatory drugs. It is made on the basis of phenylacetic acid, which helps relieve inflammation and fever, reduce pain during exacerbation of osteochondrosis. The positive effect of using the drug occurs as a result of its simultaneous action on the receptors and pain center of the brain.

When intervertebral discs are destroyed, they lose their strength and elasticity (excessive mobility of the spine occurs). As osteochondrosis progresses, bone growths appear on the vertebral body, pathologies in the muscles, ligaments and joints. Deformed structures begin to compress the arteries and roots of the spinal cord: blood circulation and absorption of nutrients in damaged tissues deteriorate (the inflammatory process begins). The consequence of blood stagnation in the vessels is: accumulation of metabolic products, oxidation of the environment at the site of inflammation. Under such conditions, cells cannot perform their functions: they die (pain appears).

Once in the body, Diclofenac prevents the synthesis of arachidonic acid (the main “provocateur” of the inflammatory process) by degeneratively changed cells. In addition, it improves blood circulation, prevents the destruction of healthy tissue (swelling decreases, inflammation disappears, pain subsides).

Diclofenac is used not only for the treatment of the spine. It is also prescribed for adnexitis, spondyloarthritis, sciatica, sinusitis and other ailments accompanied by pain and inflammation. For osteochondrosis, the following forms of the drug are prescribed: solution for intramuscular administration, topical and oral agents, rectal suppositories. The frequency of taking the medicine and dosage is determined by the doctor.

Price for the drug in the pharmacy

The price of Diclofenac suppositories may vary depending on the city and the pharmacy chain where the drug is purchased. On average, a package of 10 100 mg suppositories will cost 233 rubles, if it is made in Germany. A package with the same number of candles and the same dosage, but made in Russia, will cost 56 rubles, which is almost 5 times cheaper.

Although domestically produced drugs are cheaper, preference is still given to imported ones due to their higher quality and effectiveness. But here everyone decides for himself what suits him best. It is better, before purchasing, to consult with your doctor and find out which drug to choose and how to take it in order to get the desired result and minimize possible side effects.

Reasons for the popularity of the drug

The drug has reasons for its popularity: the drug has been on the market for a long time and has a proven mechanism and effect. In its activity and effect on inflammation, Diclofenac is superior to many non-steroidal anti-inflammatory drugs, such as Butadione, Ibuprofen, Acetylsalicylic acid.

In ankylosing spondylitis, its clinical activity is comparable to the average therapeutic dose of steroids, and the number of side effects is less than that of Prednisolone. Diclofenac also

• tablets - from 15 to 60 rubles, average price - 40 rubles per pack;
• ointment and gel in the range of 60-100 rubles;
• injection solution – 30-70 rubles;
• drops for instillation into the eyes - 60-90 rubles.

This drug is produced by domestic companies, which means it has an original form at a relatively low price. A large number of forms of use - oral, local and parenteral - allows its use in a very wide range of pathologies.

Side effects and possible complications from Diclofenac have been carefully studied and are relatively predictable. Over the course of many years of use, studies have been conducted that have made it possible to scientifically substantiate contraindications and restrictions for use. All this makes taking the drug safe if aware and prescribed according to indications and taking into account the condition of other organs and systems.

Diclofenac is one of the few drugs that can be prescribed in one form or another to pregnant and breastfeeding women if necessary. The use of local forms is practically unlimited, except for the last trimester. And tablet versions, subject to the dose and course, are relatively safe and are allowed for prescription. Diclofenac can also be used with caution in children over 6 years of age and in the elderly.

The great advantage of the drug is its dose-dependent effect and dose-dependent toxicity. Therefore, when choosing a dosage regimen, it is possible to predict both complications and the severity of the main effect of the drug.

Watch this video about the indications for use and benefits of Diclofenac:

Best Medication Options for Fever

Since Diclofenac is not the optimal choice for elevated temperatures, it is better to use other drugs instead, especially for a child and during pregnancy.

For children

Syrups or suppositories with paracetamol (from birth) or ibuprofen (from 6 months) are considered the safest. They help normalize the temperature within 3-4 hours after administration. If the effectiveness is insufficient, the doctor may prescribe nimesulide in suspension. Trade names of such medicines:

• with paracetamol - Panadol, Cefekon, Efferalgan;
• with ibuprofen – Ibuprofen for children, Maxicold for children, Nurofen for children;
• with nimesulide - Nise, Nimulid.

Ibuprofen Maxicold Nurofen

Benefits of Diclofenac suppositories

Diclofenac suppositories help get rid of uncomfortable conditions that are not customary to talk about out loud. Suppositories have a whole list of advantages over other dosage forms of this active substance. They do not cause complications possible with parenteral use (abscesses, necrosis, infiltrates).

Since suppositories are administered rectally, local irritation to the stomach is eliminated, and the risk of ulcers and erosions of the mucous membrane is reduced . The rectum has a good blood supply, so the drug is quickly absorbed into the blood, providing an additional systemic effect. The number of medications taken per day is reduced. A tangible result from use occurs almost immediately. Diclofenac suppositories are not addictive, so over time no additional increase in dose is required to maintain the therapeutic effect.

The price of Diclofenac suppositories is significantly lower than its analogues. Depending on the package configuration and the amount of active ingredient, the cost varies from 50 to 100 rubles. The drug occupies a special place in the group of NSAIDs. Despite the fact that many new drugs have now appeared, Diclofenac is able to help with pain symptoms of varying degrees of intensity.

Potential harm of Diclofenac

The potential harm of Diclofenac lies in the likelihood of developing adverse symptoms from vital systems, as well as the occurrence of emergency, including surgical pathologies. This drug has been on the market for a very long time, so all the unwanted effects have been carefully studied.

Several studies have been conducted on this subject in the scientific literature: Danish scientists have proven its pronounced effect on the cardiovascular system with the development of heart attack, atrial fibrillation and sudden cardiac death 20-30% more often than in the population.

Studies have also shown a high risk of gastrointestinal bleeding. Therefore, experts are considering banning the drug for permanent use due to the negative impact on vital organs.

We recommend reading about the benefits of using Diclofenac retard. From the article you will learn about the main characteristics of the drug, indications and contraindications for use, and side effects. And here is more information about how to use Diclofenac suppositories for prostatitis.

Why is it harmful to the human body?

Diclofenac can cause complications in many organs and systems - allergic reactions, ulcers in the gastrointestinal tract, etc., so the drug can be harmful to the human body.

Also, a negative attitude increases the difficulty of removing the drug, since it is completely bound to blood proteins, which does not allow the body to quickly cleanse the toxic substance. The mechanism of action of the drug is associated with the effect on the synthesis of anti-inflammatory mediators and can cause allergic reactions:

• exanthema;
• erosion;
• erythema;
• papules, vesicles;
• angioedema;
• Stevens-Johnson syndrome;
• Lyell's syndrome;
• bronchospasm;
• eosinophilic pneumonia;
• systemic anaphylactic reactions.

Bronchospasm

Body reactions

With local application, contact dermatitis and irritation may develop, and with intramuscular use, infiltration and even necrosis. Allergic reactions to Diclofenac mean that a person has an inadequate reaction of the body to other NSAIDs, which limits the use of substances of this group with a similar mechanism of influence on inflammation.

In people with bronchial asthma, the course of the underlying disease may be complicated by the appearance of attacks, as well as conjunctivitis and allergic rhinitis.

From the gastrointestinal tract

Diclofenac negatively affects the condition of the gastrointestinal mucosa. The effect of the drug on the enzymes cyclooxygenase 1 and 2 leads to the blocking of not only the synthesis of anti-inflammatory mediators, but also substances that protect the gastric mucosa. This leads to a weakening of the protective properties of the integument and a deterioration in its blood supply, since these compounds stimulate blood flow in these organs.

Therefore, the risk of acid damage increases in diseases such as gastroesophageal reflux, gastritis and peptic ulcers.

An exacerbation of inflammatory bowel disease may also occur. Complications appear:

• swelling and erythema of the mucous membrane;
• surface ulceration;
• increased bleeding;
• development of pain in the epigastrium and in the navel area;
• the appearance of nausea, vomiting, heartburn, various bowel disorders: from constipation to diarrhea.

Diclofenac also increases the risk of gastrointestinal bleeding due to its effect on the epithelial surface and blood system. Complications from the gastrointestinal tract are higher with long-term use of the drug: studies have found that erosions appeared in 1% of patients when taken for a year and in 3-4% when taken for more than 1 year. If the pancreas is damaged, an acute attack of pancreatitis may develop.

From the liver

The drug is intensively metabolized in the liver and affects the function of this organ. Liver transaminase levels may increase, and symptoms such as itching, loss of appetite, nausea, darkening of urine and discoloration of stool may appear. In severe cases, drug-induced hepatitis develops.

Before using Diclofenac in people with liver failure, it is necessary to monitor the levels of ALT, AST and bilirubin; monitoring is repeated 2 weeks and a month after administration.

Liver cirrhosis is a contraindication to the use of Diclofenac, since it can decompensate with the development of hepatic encephalopathy and even coma.

How does it affect the nervous system?

On the part of the nervous system, the medicine can cause:

• insomnia, apathy;
• decreased concentration and memory;
• aseptic meningitis;
• excitation;
• dizziness and headache;
• impaired visual perception, tinnitus;
• extremely rarely - vestibular complications.

Therefore, it is not recommended for persons who are engaged in intense mental work and with a high concentration of attention to take the drug at work, and they should not do this if the patient drives a car.

The effect of Diclofenac on the nervous system is realized only when taking the medication; after completing the course, all functions are restored.

From the kidneys

Since the substance is excreted through the kidneys, toxic damage is sometimes possible with the development of papillary necrosis (necrosis of kidney tissue elements), nephrotic syndrome and acute renal failure. In patients with reduced renal function, it is necessary to monitor blood creatinine levels and glomerular filtration rate.

In case of chronic renal failure above stage 3A, the drug should be limited to strict life-saving indications with constant monitoring of renal function.

How does it affect the blood?

Diclofenac affects the blood in the following way: under its action, the migration of immunocompetent cells to the site of inflammation is reduced, which reduces inflammation, but further influence depresses the blood system.

Aplastic and hemolytic anemia may develop with a decrease in red blood cells and hemoglobin, an increase in clinical symptoms of anemia: weakness, dizziness, flashing spots before the eyes, tachycardia and liver damage due to hemolysis of red blood cells and increased load on the liver with their processing. These forms of anemia are very difficult to treat even after complete drug withdrawal.

Symptoms of anemia

Diclofenac can affect the cells of the immune system from a decrease in their number in the form of leukopenia to complete agranulocytosis, which will be manifested by a pronounced decrease in the protective properties of the body and the development of infectious complications.

The drug has the greatest effect on the coagulation system, reducing platelet aggregation, and subsequently their number. Normally, during bleeding, the products of the arachidonic pathway stimulate aggregation, that is, the gluing of blood cells, but when enzymes are blocked, this process is disrupted. As a result, blood clotting is reduced. This leads to increased bleeding and difficulties in stopping bleeding in this category of patients.

Contraindications for use

The drug is contraindicated for use in:

• hypersensitivity, including to other non-steroidal anti-inflammatory drugs;
• hematopoiesis disorder of unspecified etiology;
• peptic ulcer of the stomach and duodenum;
• inflammatory bowel diseases in the acute stage;
• “aspirin” bronchial asthma;
• children under 6 years of age;
• last trimester of pregnancy.

Diclofenac is prescribed with great caution if:

• renal or liver failure;
• cardiac rhythm and conduction disturbances;
• heart failure;
• cardiac ischemia;
• hypertonic disease;
• elderly age;
• children's age from 6 to 12 years;
• first and second trimester of pregnancy.

When breastfeeding, you can use Diclofenac in a short course for health reasons, but you should monitor the child's condition for liver dysfunction and the development of allergic reactions. The drug should not be prescribed to women who are planning pregnancy or treating infertility. Diclofenac significantly reduces fertility.

The main thing is to use it correctly

For products to be effective in solving back problems, they must be used correctly. It is important to understand that the event does not require fuss and only takes a few minutes. It is best to administer the drug after emptying the rectum.

This will allow the active substances to penetrate the affected area more quickly. If you have difficulty passing stool, use an enema. After hygiene, pick up a candle. As a rule, medications are stored in the refrigerator before use, so the suppository must be warmed in your hands.

Before use, you will need to lie on your side with your knees bent. After opening the package, the drug is injected into the anus. I advise you to relax at this moment, then the procedure will be much easier. Then just lie down for half an hour.

By the way, pain-relieving suppositories can be used not only for back problems, but also for acute cervical osteochondrosis. The effect will be just as fast and long lasting. In the instructions for suppositories you can always find out how much time is needed for the course.

Tips for safe use

In order for the use of the drug to be safe, it is necessary to strictly adhere to the dosage regimen and contraindications, as well as monitor some indicators of the functioning of internal organs. Correctly chosen dosage, taking into account indications and restrictions, has a very low chance of causing complications. To ensure safety, you need to know that there are no problems with the liver, kidneys or cardiovascular system.

To monitor liver function, a blood test is taken for the enzymes AST, ALT, and bilirubin metabolism is also assessed. An increase in indicators when taken by more than 3-5 times with the development of clinical signs is a reason to discontinue Diclofenac.

Blood creatinine and glomerular filtration rate are also monitored, and a general urine test is taken. A decrease in filtration rate, an increase in creatinine and other nitrogenous wastes, as well as the appearance of a large amount of epithelium, casts and protein in the urine indicate a toxic effect of the drug on the excretory system.

When prescribing diuretics and digoxin, you need to take a blood test for potassium levels before and during taking Diclofenac, and you should also monitor the intake of this trace element with medications and food (bananas and raisins contain a lot of potassium). Tests should be done once a week and if symptoms appear, a violation of the metabolism of this element: changes in the rhythm and functioning of the heart.

Optimization of the dosage regimen, and therefore the amount of toxic substance in the body, is facilitated by knowledge of the mechanism of pain when taking Diclofenac. It can be effective to prescribe the drug at specific times of day to reduce the total dose.

For inflammatory joint pain, the peak of discomfort occurs in the morning, so it is advisable to take a long-acting tablet at night. For mechanical pain in degenerative diseases, it is better to take the pill in the morning, because the pain increases in the evening.

In any case, the safe use of the drug can be ensured by a doctor after consultation and examination, which will clarify all the details of the regimen for using this medication.

If you have heart problems

To reduce the effect on the functioning of the cardiovascular system, simultaneous administration of Diclofenac with acetylsalicylic acid, which is used as an antiplatelet agent in small dosages in many cardiac pathologies, should be avoided. The risk of heart complications without this drug and the risk of complications and adverse reactions when prescribed simultaneously should be assessed. You should also measure your blood pressure regularly.

If there are problems with the gastrointestinal tract

To protect the gastric mucosa, you should take the drug Omeprazole at a dose of 20 mg per

day throughout the course of taking Diclofenac.

Omeprazole is a proton pump inhibitor and reduces acidity, protecting the surface from damage. Gastroprotectors can also be used.

To reduce the risk of bleeding, a complete blood count and platelet count may be assessed before the appointment. The simultaneous use of oral anticoagulants and antiplatelet agents should be avoided. If bleeding develops, you need to have Dicinon or sodium etamsylate with you to relieve symptoms.

The absorption of the drug does not depend on food: food only slows down the rate of entry of the drug into the blood. Therefore, you can take Diclofenac after meals, which will reduce its toxic effect on the gastrointestinal tract.

During pregnancy

In nursing mothers, the use of Diclofenac is limited by its penetration into milk. To reduce this, you should take the tablets immediately after feeding, then by the next time the concentration of the drug in the blood will decrease significantly.

How can Diclofenac be replaced in the treatment of prostatitis?

Analogs of Diclofenac in the treatment of prostatitis are other anti-inflammatory drugs with which it can be replaced:

• in tablets: Voltaren, Ortofen, Naklofen, Dialpirad powder for oral administration, Ketoprofen in tablets and powder for oral administration;
• suppositories: Voltaren, Diclovit, Metamizole, Tenoxicam, Phenacetin.

Ketoprofen Ortofen Voltaren Naklofen
However, if you are allergic to non-steroidal anti-inflammatory drugs, then you cannot replace them with drugs from this group.

How to use candles

Diclofenac rectal suppositories are administered directly into the rectum. A cleansing enema is recommended in advance if it is not possible to empty the intestines naturally.

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The dosage of the drug is determined depending on the composition of the drug (Diclofenac 100 mg or Diclofenac 50 mg) and is usually 100-150 mg per day in two or three doses. In especially severe cases, the dose may be increased by the doctor.

The duration of the course is determined by the doctor and averages about a week. At the beginning of treatment, the patient is advised to listen to his condition, because Diclofenac suppositories can cause a number of side effects:

• From the digestive system: development of pain in the upper part of the stomach, nausea, periodic vomiting, diarrhea.
• On the part of the hematopoietic system - the development of anemia, a decrease in the level of platelets and leukocytes.
• From the nervous system - periodic dizziness, headaches, sleep disturbances, fatigue, anxiety, irritability. Less commonly, visual disturbances (hallucinations, blurred objects), tremors, and tinnitus may occur.
• From the urinary system - decreased kidney function.
• On the part of the skin - redness, irritation, burning at the site of insertion of the suppository.
• From the cardiovascular system – surges in blood pressure.
• Allergic rashes, itching.

Before using suppositories, it is recommended to empty the intestines for better absorption of the active component.
Suppositories must be inserted as deeply as possible. The manipulation is carried out at night. If any undesirable effect occurs, you should immediately stop using Diclofenac suppositories, replacing them with another drug.

During the period of use of Diclofenac, it is necessary to abstain from drinking alcohol, and you should not drive vehicles, because. the drug affects the speed of psychomotor reactions.

It is prohibited to use Diclofenac in the following conditions:

• Hemorrhagic colitis;
• Rectal, anal bleeding;
• Bronchial asthma;
• Inflammation of the rectum;
• Hematopoietic disorders;
• Hemorrhoids in the acute stage;
• Ulcers of the stomach and intestines.

Also, suppositories should not be used by patients under 15 years of age and by persons with individual intolerance to the components of the drug.

With caution and under the supervision of a doctor, suppositories should be used by elderly people, patients suffering from high blood pressure, heart failure, and inflammation of the digestive tract.

During long-term therapy using Diclofenac suppositories, blood counts should be periodically monitored to exclude the development of other pathologies.

If you use other drugs during the use of Diclofenac, you should inform your doctor about this in order to prevent a possible negative effect from the interaction.

Diclofenac suppositories should be used with caution. They are not intended for people with blood pressure problems, intestinal or stomach diseases, liver or kidney disease, rectal bleeding

There are no particular difficulties in using Diclofenac in the form of suppositories. The technique is very simple:

• before using the drug, if possible, it is necessary to cleanse the intestines for better absorption of the drug (go to the toilet, give an enema);
• Wash the hands;
• remove the candle from the shell;
• lie on your left side (leave your left leg lying straight and bend your right leg at the knee) or on your back (bend your legs at the knee joints and spread them apart);
• spread your buttocks with your hand;
• With your free hand, insert the candle with its pointed end into the rectum;
• lie down for ten to fifteen minutes.