Isoprinosine for children reviews and instructions for use

Composition, release forms and names of Isoprinosine

tablets for oral administration of inosine pranobex (inosiplex)
Isoprinosine tablets contain the following substances as auxiliary components:

• Mannitol;
• Wheat starch;
• Magnesium stearate.

In everyday speech, qualified names are often used to refer to this drug, such as Isoprinosine 500

,
Isoprinosine 50
,
Isoprinosine 30
, etc. In these names, the number 500 means the dosage of the active component of the drug. And the numbers 30 and 50 mean the number of tablets in the package. Such markings allow doctors, pharmacists and patients to quickly understand exactly how many tablets are needed.

Analogs

Preparations with an active substance similar to the active component of Isoprinosine (inosine pranobex) are produced under the following trade names:

• Groprinosin;
• Modimunal;
• Normomed;
• Metisoprinol;
• Groprinosin-Richter.

Groprinosin is an analogue of Isoprinosine

The use of Isoprinosine against human papillomavirus, both as monotherapy and in combination with other drugs and destructive therapeutic methods, allows one to successfully cope with the manifestations of PVI. But to achieve a lasting result, a specialist must prescribe the product and monitor its use.

Doctors and parents about Isoprinosine

In Russia, the sale of this immunomodulator began in the late 90s. Since then, a large number of clinical studies have been conducted on the effectiveness of the drug in various infectious diseases. Reviews from doctors about the effectiveness of Isoprinosine for influenza and ARVI are only positive.

Experts also note immunomodulatory and antiviral effectiveness in the treatment of herpesvirus infections (cytomegalovirus, Epstein-Barr virus, herpes simplex), human papillomavirus infections in 85% of patients on average.

Doctors prescribe Isoprinosine for the treatment of both acute and chronic recurrent viral diseases:

1. Infectious mononucleosis, both in acute form and in the form of chronic fatigue syndrome in adults, is one of the objects of targeted study of the action of Isoprinosine. These diseases are initiated by the Epstein-Barr virus, which has an affinity for the tissues of the nervous system, liver and salivary glands. Infectious mononucleosis suffered in childhood can lead to chronic fatigue syndrome in adults. The disease is not always diagnosed correctly, and when the diagnosis is confirmed, it takes a long time, but is successfully treated with an immunomodulator in combination with antiviral drugs.
2. The human papillomavirus and the diseases associated with it are quite difficult to treat. According to the objective opinion of doctors, without the use of immunomodulatory drugs in the HPV treatment regimen, it is impossible to send the virus into hibernation. Considering the oncogenic danger of HPV, such medications should not be neglected.

Isoprinosine is actively used for the treatment of acute respiratory viral infections in children with bronchial asthma.

Perhaps the main advantage of Isoprinosine is the extremely rare development of side effects against the background of high-quality immunostimulation.

Among parents, reviews of the use of Isoprinosine for the treatment of ARVI in children are not so rosy. Mothers note the low effectiveness of the drug during the course of the disease: the temperature remains high, the cough and runny nose do not go away. You should not rely heavily on the subjective opinions of parents on forums. Probably too much hope is placed on the medicine. You should know that not a single modern immunomodulator is capable of instantly ridding a child of fever, painful cough and other unpleasant symptoms of ARVI or influenza.

Firstly, the main task of Isoprinosine for acute respiratory viral infections and influenza is to suppress symptoms as soon as possible, but not completely eliminate them.

Secondly, the drug activates all parts of the immune system to speed up the death of the virus and prevent the addition of bacterial flora. In case of pandemic swine flu, isoprinosine prevents a serious complication – interstitial pneumonia. For seasonal influenza and ARVI, the medication prevents the development of otitis, tonsillitis, frontal sinusitis, ethmoiditis and other purulent organ lesions.

Thirdly, given the fact that, unlike bacteria, viruses have an affinity for almost all organ tissues, they can cause such serious diseases as diabetes mellitus and glomerulonephritis in the future. Damage to the pancreas and glomeruli of the kidneys is often observed during influenza infection. Thanks to the optimal regulation of immunity, Isoprinosine prevents hyperimmune reactions in the body that can provoke autoimmune diseases.

Proper prevention should be aimed at strengthening the body's defenses

Indeed, the choice of an immunomodulator with antiviral activity should be made individually and by a doctor

. Not always the medicine that suits your friends will suit you and your child. The effectiveness of the drug depends on the nature of the initial gaps in the immune response and concomitant pathology. Corrective schemes for modulating immunity in frequently ill children are carried out only after laboratory tests during the inter-illness period.

Modern analogues

Isoprinosine is a fairly expensive drug, and therefore many patients would be very happy to purchase a cheaper drug that could replace it.
So, the price for this medication starts from 700 rubles. Therefore, it is really worth trying to find an analogue. Note that analogues have the same active ingredient as the original drug. But it is worth considering that, unlike branded drugs, similar drugs or, as they are also called, generics do not undergo clinical trials. It is in this regard that the absence of costs for the necessary research has a positive effect on the cost of a particular medicine. That's why generics are usually much cheaper than original drugs. Many people are interested in reading reviews about Isoprinosine analogues.

The Russian pharmaceutical market, unfortunately, cannot please with a wide selection of generics of inosine pranobex. To date, only one analogue of Isoprinosine has been registered, which is Groprinosin. This analogue is produced in Poland and Hungary. Due to the presence of the symbol “S” in the Latin name, the drug is sometimes transformed into “Groprinosin” during translation. The cost of Groprinozin is slightly lower than that of the original brand, but the difference, let’s say, is not so great. So, when buying twenty tablets, this analogue will cost only 70 rubles cheaper compared to the original medicine.

It is worth emphasizing that the quality of the drugs “Isoprinosine” and “Groprinosine” is approximately the same. Thus, when replacing a brand-name drug with an analogue, you can be completely confident in the absolute effectiveness of the substitute.

Indications for use

Therapeutic therapy, as well as prevention using the drug “Isoprinosine” is indicated for a number of ailments and pathological conditions:

• Viral infections and influenza
• Ailments of infectious origin provoked by herpevirus types 1-5 (treatment of herpevirus types 6, 7 and 8 is possible), as well as herpetic keratitis
• Chickenpox, herpes zoster
• Worsening of measles symptoms
• For mononucleosis caused by specific viruses
• Cytomegalovirus infection, which is caused by herpevirus type 5
• Papillomavirus or so-called HPV, which manifests itself as fibrous papillomas of the larynx
• Polyps of the cervical canal
• HPV of the external and internal genital organs in both women and men, therapeutic therapy to get rid of warts.

Directions for use: special instructions

To figure out how to take Isoprinosine for children, you need to carefully read the instructions that come with each dosage form. The effectiveness of the medicine will be higher the earlier it is started (ideally, after the first signs of an acute viral infection appear).

Special instructions:

• The effect of Isoprinosine on the body of a nursing and pregnant woman, the degree of its penetration into breast milk and its effect on the growth and development of the fetus have not been fully studied. Therefore, it is not recommended to use this drug in pregnant and nursing mothers;
• the combined use of immunosuppressants may reduce the therapeutic effect of the drug, so this situation should not be allowed;
• long-term use of the medication (more than two weeks) requires a clinical blood test to monitor uric acid levels;
• using the medicine for a month or more requires mandatory monitoring of liver function indicators;
• if a person takes medications that reduce uric acid levels, this does not relieve him of the need to monitor the size of this indicator by taking blood tests;
• During therapy with Isoprinosine, you can drive vehicles, work with complex mechanisms, this medicine does not in any way affect the speed of human reactions.

You can purchase the drug only upon presentation of a medical prescription. Self-prescription of this drug, especially for use in children, is unacceptable.

Therapeutic effect

Stimulation of the immune system by Isoprinosine occurs due to the activation of the production of interleukins 1 and 2, as well as interferon gamma, which have anti-inflammatory activity. In addition, the production of interleukins 4 and 10 decreases, which, on the contrary, maintain and enhance inflammation in various organs and tissues. As a result of this modulation of the production of interleukins and interferon, the intensity of the inflammatory process in any tissue or organ decreases, as a result of which the lesion decreases and the normal cell structure is restored.

In addition, Isoprinosine activates the work of cytotoxic T-lymphocytes and natural killer cells (NK cells), which destroy cells damaged by viruses, which also leads to a reduction in the size of the inflammatory focus and restoration of the structure of an organ or tissue. In parallel with the increase in the activity of cytotoxic T-lymphocytes and NK cells under the influence of Isoprinosine, there is an increase in the production of T-suppressors and T-helpers, which seem to help other cells of the immune system to “recognize” and destroy viruses or cellular structures affected by them. Separately, it should be noted that under the influence of Isoprinosine, the production of IgG antibodies increases, which also contribute to the destruction of virus-infected cells.

All of the listed components of activation of the immune system (increased activity of cytotoxic T-lymphocytes, NK-cells, T-helpers, T-suppressors, as well as the production of IgG, interleukins 1 and 2 and interferon gamma), aimed at destroying viruses, are implemented in the systemic bloodstream. That is, all these cells and substances end up in the blood, which flows to the affected organ or tissue. And when the blood flow delivers all the listed cells and substances to the required area, they are released and penetrate into the thickness of the tissue, where they exert their effect.

In addition to reactions of activation of the immune system that occur in the bloodstream, there are other processes that occur directly in the thickness of the affected tissues or on the mucous membranes

The reactions of the immune system in the thickness of tissues and on mucous membranes are called local immunity, and represent a very important link in the overall mechanism for the destruction of viruses and cells affected by them. After all, local immunity destroys viruses and affected cells constantly, without waiting for a massive reaction in the systemic bloodstream and, thereby, prevents pathogenic microorganisms from quickly infecting a large area of ​​tissue or organ

Under the influence of Isoprinosine, local immunity is activated, which is manifested by the accumulation of a large number of monocytes, macrophages and neutrophils in the affected area of ​​the organ, which destroy cells infected with viruses.

The direct effect of Isoprinosine on viruses is that the drug suppresses their reproduction by blocking the work of the enzyme dihydropteroate synthetase

.
In laboratory experiments, Isoprinosine successfully suppresses the reproduction of the following viruses:

• Herpes simplex types 1 and 2;
• Cytomegalovirus;
• Measles virus;
• Human T-cell lymphoma virus type III;
• Polioviruses;
• Influenza viruses types A and B;
• ECHO virus (human enterocytopathogenic virus);
• Encephalomyelocarditis virus;
• Equine encephalitis virus.

Therapeutic tactics for HPV infection

The direction and scope of therapy largely depend on the activity of HPV in the body. The human papillomavirus in epithelial cells can exist in two forms.

Destruction of papillomatous formations alone does not guarantee a lasting effect. The absence of relapses of the disease can be achieved by using medications that enhance the local and general immune response, converting the virus into an inactive form. These drugs include Isoprinosine, which is registered in more than 70 countries and has received numerous positive reviews from practicing specialists. However, it should be noted that there has been no evidence of its effectiveness in studies.

Isoprinosine instructions for use

Dosage calculation for children and adults

• – the dosage is calculated individually according to body weight, based on the ratio of 50 mg per 1 kg of weight per day. That is, if an adult’s body weight is 70 kg, then the daily dosage of Isoprinosine for him is 70 * 50 = 3500 mg, which corresponds to 7 tablets (3500/500). This calculated number of tablets is divided into 3 to 4 doses per day. Adults may not calculate the dosage of Isoprinosine individually, based on the fact that the average daily dose of Isoprinosine for a person with normal body weight (60–80 kg) is 6–8 tablets. In addition, you can use a simplified version of calculating the daily dosage of Isoprinosine - 1 tablet for every 10 kg of weight.
• Children 3 – 11 years old

  – the dosage is calculated individually according to body weight, based on the ratio of one tablet for every 10 kg of weight per day. That is, if a child’s body weight is 35 kg, then he should take 3.5 Isoprinosine tablets per day. The total daily amount of the drug for children is divided into 3–4 doses.

For children aged 3 to 11 years, the maximum daily dosage of Isoprinosine should not exceed the ratio of 50 mg per 1 kg of weight, regardless of the severity of the disease. For example, if a child weighs 20 kg, then he needs to take 2 tablets per day, which is 1000 mg. To check whether a given dosage does not exceed the maximum permissible, you should divide it by the child’s body weight - in our example, 1000/20 = 50. Then the resulting figure must be compared with 50, and if it is less, it means that the dosage is below the maximum permissible norms. If the resulting figure is more than 50, then the dosage of Isoprinosine is greater than the maximum allowable norm for a child. In this case, the dosage should be reduced. In our example, the calculated dosage is equal to the maximum permissible for a child, so it can be used.

Elderly people (over 65 years of age) should take Isoprinosine at normal adult dosages without reducing them.

The duration of use of Isoprinosine in individually calculated dosages is entirely determined by the type of disease.

special instructions

With long-term use of Isoprinosine, the cellular composition of peripheral blood should be monitored every 4 weeks by calculating the leukoformula as part of a general blood test, and also monitor the functioning of the liver and kidneys by determining the activity of AST and ALT, as well as the concentrations of creatinine and uric acid in the blood.

In addition, it is necessary to frequently (at least once a week) monitor the concentration of uric acid in the blood when using Isoprinosine concomitantly with drugs that impair kidney function or promote the accumulation of uric acid.

Interaction with other drugs

Drugs from the groups of xanthine oxidase inhibitors (for example, Allopurinol, Zilorik, Milurit, Purinol, Allopin, etc.) and uricosuric drugs (salicylates, including Aspirin, Probenecid, Benemid, Sulfinpyrazone, diuretics, etc.) increase the risk of increasing the concentration of urinary acids in the blood and the development of gout.

With the simultaneous use of Isoprinosine with Acyclovir and Zidovudine, the antiviral effect of the latter is enhanced.

Is it possible to take the drug in combination with alcohol?

It is worth emphasizing that alcohol is incompatible with this drug; therefore, during the entire course of treatment, you should refrain from drinking drinks that contain even a small amount of ethyl alcohol. This incompatibility of Isoprinosine with alcohol is explained by several factors:

• Alcohol can enhance the side effects of Isoprinosine, increasing the risk of their development. This means that when taking alcohol in combination with this drug, a person is highly likely to develop arrhythmia along with renal colic, renal failure, pyelonephritis or allergic reactions.
• In addition, Isoprinosine can have a strong effect on the liver. This organ is also subject to very noticeable stress due to alcohol consumption. Thus, the combination of “Isoprinosine” with alcohol is very toxic and harmful to the liver, as it can provoke jaundice along with cholestasis, hepatitis and other disorders of this organ.
• In addition, Isoprinosine is able to increase the production of interferon, which, in turn, enhances the negative effect of alcohol on the human body. If you use Isoprinosine in combination with alcoholic beverages for several days, then the development of psychopathology is very likely, which will manifest itself in depression and suicidal thoughts. Among other things, it is very likely that disturbances in the activity of the peripheral nervous system will occur, which will be expressed by numbness, tingling of the limbs, and the like.

Thus, “Isoprinosine” increases the harmful effects of ethyl alcohol several times. In this regard, it should never be combined with alcohol. Reviews of the use of Isoprinosine are presented at the end of the article.

When and how to use Isoprinosine

The drug is used for the treatment and prevention of viral infections in both adults and children.

Reception is indicated for the following diseases:

1. Seasonal acute respiratory viral infections and influenza, including pandemic ones.
2. Herpes virus infections (herpes simplex of any localization, chickenpox and its recurrence - herpes zoster, cytomegalovirus infection, infectious mononucleosis).
3. Measles.
4. Human papillomavirus infection in any manifestation (warts, respiratory papillomatosis, cervical dysplasia, genital warts).
5. Molluscum contagiosum.

Contraindications:

1. Kidney failure.
2. Gout.
3. Children under 3 years old.
4. History of allergic reactions.

Children under three years of age should not take Isoprinosine.

For the prevention of ARVI and influenza during the infection season, the dosage of Isoprinosine is 0.5 g per day in children, and 1 g in adults. The daily amount of tablets is divided into 2-3 doses. Take the medicine for 30 days, 2 times per epidemic. season (for example, November and February).

The most common side effect is headache, which goes away after stopping the medication. Dizziness, loss of appetite, nausea, and allergic skin reactions are rarely recorded.

The effect of the drug against the herpes virus

Among the inhabitants of planet Earth, 98% are susceptible to infection with herpesvirus infections, which are common not only in adults, but also in children under 6 years of age.

No medicine can completely “eradicate” the virus from the human body, but isoprinosine for children, according to numerous reviews and opinions of attending physicians, if you do not deviate from the instructions for its use, can eliminate itching, blisters and pain in the early stages of the disease. .

In addition, it has an excellent effect on areas of chickenpox and shingles, stopping the rate of rashes and eliminating painful symptoms.

Release form and composition

Isoprinosine and also groprinosin are produced in tablets of 20, 30 and 50 tablets in one package. Although in Russian pharmacies today you can buy a small plate (blister) of 10 pieces. The pharmacist simply takes the package, separates the blisters and sells the buyer one blister containing exactly 10 tablets of the drug. At the same time, there is no need to buy the entire package at once, the price of which is high.

Composition: active ingredient – ​​inosine pranobex. The weight of one tablet is 500 mg.

Analogs

• Novirin is a direct analogue (also contains inosine pranobex). The drug is made in Ukraine.
• Epigen intimate - detailed information
• Panavir - more details
• Allokin-alpha - detailed instructions

Description of Isoprinosine

To date, the drug is presented only in tablet format. Its therapeutic effect is based on slowing down the reaction of DNA and RNA production in the nucleus of the viral cell. In addition, Isoprinosine is a good immunostimulant.

While taking the medication, the production of endogenous cytoleukins and human interferon is activated. It is precisely this action that determines the properties of the drug:

• antiviral;
• anti-inflammatory;
• immunostimulating.

The drug is widely used in the treatment of acute forms of HPV. It affects not only the changed cells, but also the virus itself.

Isoprinosine enhances systemic immunity and also activates local immune defense. This means that its intake has a direct effect on the epithelium affected by the virus.

The dual effect of Isoprinosine - immunostimulating and antiviral - allows the drug to be used in the fight against many HPV genotypes, including highly carcinogenic ones.

The medicine is quickly absorbed by the intestinal mucosa. The maximum of the drug in the blood is determined one and a half hours after administration. Isoprinosine is excreted through the kidneys along with urine. It does not have a cumulative effect: it is completely eliminated after 2 days.

Side effects and contraindications Isoprinosine

Almost all medications, including Isoprinosine, cause side effects. As a rule, this happens when taking medications in maximum doses, when using a medication for a long time, or when taking several medications at once.

Most common side effects

The most common side effect is an increase in the level of uric acid in the blood serum and urine, which normalizes during treatment or a few days after the end of treatment.

Single side effects

When using Isoprinosine, the following may occur:

• dizziness, headache, weakness;
• dyspeptic symptoms at the beginning of treatment, in rare cases - increased transaminase activity.

In exceptional cases, joint pain occurs.

Overdose

Cases of overdose have not been identified or described in the scientific literature. Overdose may cause an increase in uric acid levels in the blood plasma and urine. Treatment is symptomatic.

Contraindications:

• urolithiasis disease;
• gout;
• arrhythmias;
• hyperuricemia;
• chronic renal failure;
• children under 3 years of age (body weight up to 15-20 kg);
• hypersensitivity to the components of the drug.

Duration of the average course of therapy

Every good doctor has his own treatment regimen, which has already proven its effectiveness. Therefore, there is probably no single standard course of treatment. The instructions indicate that the duration of therapy for an uncomplicated form of infection can range from five days to two weeks. In addition, experts in some cases recommend continuing to take Isoprinosine for another two weeks after the symptoms of the disease disappear. This is required in order to avoid relapse of the disease.

Long-term use of this drug for a month or more is possible. And again, it is necessary to emphasize that in such a delicate matter as the treatment of a viral infection, you should rely not on instructions or the opinion of a friend, but directly on the experience, as well as on the knowledge of your attending physician.

Isoprinosine analogue

The instructions note the presence of analogues of the drug. There is only one product with a similar active ingredient - Groprinosin. There are medications with antiviral activity used to treat and prevent infections. Positive reviews from doctors and patients include:

• Zenerite;
• 5 NOK;
• Acyclovir;
• Amiksin;
• Arbidol;
• Panavir.

Analogs of the drug have antiviral and immunostimulating effects, but are often less effective than Isoprinosine. Doctors prescribe medications in tablets with a similar therapeutic effect for the treatment of HPV and chronic viral diseases:

• Kagocel;
• Lavomax;
• Amizol;
• Allokin-Alpha;
• Tylaxin;
• Tiloron;
• Ergoferon;
• Hyporamine;
• Alpizarin.

Contraindications

Treatment of HPV infection with the drug is contraindicated if the patient has:

• individual intolerance to the constituent components;
• kidney pathologies (urolithiasis, chronic renal failure);
• heart rhythm disturbances;
• gout;
• body weight less than 15–20 kg (children over 1 year old can theoretically be prescribed the drug, but given weight restrictions, in practice the drug can be taken after 3 years).

When it comes to allergic manifestations, it is necessary to take into account not only the reaction to the active substance, but also to the additional auxiliary components included in the product.

Side effects of Isoprinosine

When using the medicine, it is necessary to take into account that side effects may occur. The instructions stipulate that the occurrence of such moments requires contacting a doctor to change the dosage or discontinue the drug. The use of the drug may provoke:

• from the gastrointestinal tract - constipation, diarrhea, epigastric pain, nausea, vomiting;
• dermatological reactions – skin itching, rashes.

The instructions for use note that if the dosage of the drug is violated, problems with the body systems cannot be ruled out:

• nervous – insomnia, drowsiness, headache, weakness, dizziness;
• urinary – polyuria – increased amount of urine;
• biliary tract, liver - increased activity of alkaline phosphatase, urea concentration in blood plasma;
• musculoskeletal system - exacerbation of gout, the appearance of joint pain.

Advantages of the drug

The spectrum of action of Isoprinosine gives it a number of advantages in the treatment of not only various manifestations of human papillomavirus infection (PVI), but also its combination with other pathologies of the urogenital tract.

Pharmacokinetics

After oral administration, the drug is well absorbed from the gastrointestinal tract. The maximum concentration of ingredients in blood plasma is determined after 1-2 hours. It is quickly metabolized and excreted through the kidneys. Metabolized similarly to endogenous purine nucleotides with the formation of uric acid. NN-dimethylamino-2-propranolone is metabolized to N-oxide, and para-acetamidobenzoate to o-acylglucuronide. No accumulation of the drug in the body was detected. The half-life is 3.5 hours for NN-dimethylamino-2-propranolone and 50 minutes for para-acetamidobenzoate. Elimination of the drug and its metabolites from the body occurs within 24-48 hours.

Features of use

Treatment of diseases caused by the human papillomavirus with Isoprinosine should take into account certain conditions of the body, some features of the drug itself, and its interaction with other drugs.

Side effects of isoprinosine

1) Nausea, vomiting, diarrhea

2) Skin itching

3) Headache, dizziness, drowsiness

4) Joint pain and exacerbation of gout (who has gout)

1) Children under 3 years old

2) Patients with gout

3) Kidney diseases

Pregnant and breastfeeding women

Isoprinosine and analogues of the drug are not recommended for pregnant and nursing mothers, since the drug penetrates the child’s body and causes side effects.

Isoprinosine for prevention

Sometimes a child’s body needs additional immune support (for more details, see the article: the best children's vitamins for immunity). Then taking immunostimulants to prevent viral infections is indicated.

Usually the doctor recommends a preventive course in the autumn-spring period. It would not be a bad idea to take funds to strengthen the immune system during climate change (on vacation or when moving to a permanent place of residence in another region, country), stressful situations (transfer to another educational institution, difficult situation in the family).

Before giving your baby immunostimulating drugs, you should consult your doctor. Ideally, this should be an immunologist. If it is not possible to visit this specialist, it is recommended to seek advice from your pediatrician. He will help you choose the optimal strengthening drug.

A prophylactic course of taking Isoprinosine should last at least 14 days. The dosage is calculated according to the scheme - for every 1 kg of the child’s weight, 50 mg of the drug per day. The calculated amount should be divided into 3-4 doses and the baby should be given the medicine at regular intervals. If any side effects occur, prophylaxis should be stopped immediately and consult a doctor.

Isoprinosine for children Komarovsky

The tablets
are white or almost white, oblong, biconvex, with a slight amine odor, scored on one side.

Excipients: mannitol, wheat starch, povidone, magnesium stearate.

10 pieces. - blisters (2) - cardboard packs.

10 pieces. - blisters (3) - cardboard packs.

10 pieces. - blisters (5) - cardboard packs.

Isoprinosine is a synthetic complex purine derivative with immunostimulating activity and nonspecific antiviral effect. Restores the functions of lymphocytes in conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killer cells, the functions of T-suppressors and T-helpers, increases the production of IgG, interferon gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines - IL-4 and IL-10 potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against Herpes simplex viruses, cytomegalovirus and measles virus, human T-cell lymphoma virus type III, polioviruses, influenza A and B, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis. The mechanism of the antiviral action of Isoprinosine is associated with inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of some viruses. It enhances the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of the biosynthesis of viral RNA and the translation of viral proteins, increases the production of alpha and gamma interferons by lymphocytes, which have antiviral properties.

When administered in combination, it enhances the effect of interferon alpha, the antiviral agents acyclovir and zidovudine.

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After oral administration, it is well absorbed from the gastrointestinal tract. The Cmax of the active substance in the blood plasma is determined after 1-2 hours.

Rapidly metabolized. Metabolized similarly to endogenous purine nucleotides to form uric acid, NN-dimethylamino-2-propranolone is metabolized to N-oxide, and para-acetamidobenzoate to o-acylglucuronide. No accumulation of the drug in the body was detected.

T1/2 is 3.5 hours for NN-dimethylamino-2-propranolone and 50 minutes for para-acetamidobenzoate. Excreted by the kidneys. Elimination of the drug and its metabolites from the body occurs within 24-48 hours.

— treatment of influenza and other acute respiratory viral infections;

- infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis;

- herpes zoster, chicken pox;

— infectious mononucleosis caused by the Epstein-Barr virus;

- severe measles;

— human papillomavirus infection: papillomas of the larynx/vocal cords (fibrous type), human papillomavirus infection of the genitals in men and women, warts;

— chronic renal failure;

- children under 3 years of age (body weight up to 15-20 kg);

- hypersensitivity to the components of the drug.

The tablets are taken after meals with a small amount of water.

The recommended daily dose for adults and children aged
3 years and older (with body weight from 15-20 kg)
is 50 mg/kg body weight in 3-4 doses (for
adults
- 6-8 tablets / day, for
children
- 1/2 tablet per 5 kg body weight/day).

For severe forms of infectious diseases

the dose can be increased individually to 100 mg/kg body weight/day, divided into 4-6 doses.
The maximum daily dose for adults
is 3-4 g/day, for
children
- 50 mg/kg/day.

Duration of treatment for acute diseases

in
adults and children
usually ranges from 5 to 14 days. Treatment should be continued until clinical symptoms disappear and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

For chronic recurrent diseases

in
adults and children,
treatment must be continued in several courses of 5-10 days with a break of 8 days.

For maintenance therapy

the dose can be reduced to 500-1000 mg/day (1-2 tablets) for 30 days.

For herpes infection,
adults and children
are prescribed the drug for 5-10 days until the symptoms of the disease disappear; during the asymptomatic period - 1 tablet. 2 times a day for 30 days to reduce the number of relapses.

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For papillomavirus infection
in adults,
the drug is prescribed 2 tablets.
3 times a day, children -
1/2 tablet. by 5 kg/body weight/day in 3-4 doses for 14-28 days as monotherapy.

For recurrent genital warts,
adults
are prescribed the drug 2 tablets.
3 times a day, children
- 1/2 tablet. by 5 kg/body weight/day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then repeating the specified course three times at intervals of 1 month.

For cervical dysplasia associated with the human papillomavirus,

2 tablets are prescribed. 3 times a day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.

The incidence of side effects after using the drug is classified according to WHO recommendations: often (≥1%, <10%), sometimes (≥0.1%, <1%).

From the liver and biliary tract:

often - a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

Dermatological reactions:

often - itching.

From the nervous system:

often - headache, dizziness, weakness; sometimes - drowsiness, insomnia.

From the urinary system:

sometimes - polyuria.

From the musculoskeletal system and connective tissue:

often - joint pain, exacerbation of gout.

When used concomitantly, immunosuppressants may reduce the effectiveness of Isoprinosine.

Xanthine oxidase inhibitors and uricosurics (including diuretics) may contribute to the risk of increased serum uric acid levels in patients taking Isoprinosine.

After 2 weeks of using Isoprinosine, it is recommended to monitor the level of uric acid in the blood serum and urine.

With long-term use, after 4 weeks of use, it is advisable to monitor liver and kidney function every month (transaminase activity in the blood plasma, creatinine and uric acid levels).

It is necessary to monitor the level of uric acid in the blood serum when prescribing Isoprinosine in combination with drugs that increase uric acid levels or drugs that impair renal function.

Impact on the ability to drive vehicles and operate machinery

Prices for the drug and analogues of Isoprinosine

For the treatment of viral diseases, analogues of Isoprinosine from domestic and foreign manufacturers are presented on the pharmacological market. Prices for medicines depend on the country of origin. Russian medications are much cheaper.

What is the difference between Normamed and Isoprinosine?

Despite the fact that the mechanism of action due to the same active substance is similar, as well as the indications for use and contraindications, there is a difference between the drugs:

1. The auxiliary components may differ, but they have no effect on the pharmacology of the drugs.
2. Normamed is produced not only in the form of tablets, but also in the form of syrup. This form of release of the antiviral drug is preferred because it is more convenient to dose and take for children and adults who may have difficulty swallowing. Isoprinosine is available only in tablet form.
3. The age limit for prescribing antiviral drugs differs. Normamed is allowed to be given to children from 12 months. And the instructions for use of Isoprinosine warn that this medicine is not intended for children under 3 years of age, but for special indications and with extreme caution it can be prescribed to children over one year of age.
4. Normamed can be prescribed during pregnancy and breastfeeding if the doctor sees the need. Isoprinosine is strictly prohibited for pregnant and lactating women.
5. The price of medicines varies: Isoprinosine costs from 600 to 1500 rubles, Normamed - 480-1000 rubles. The more affordable cost of Normamed does not mean that this drug is less effective or more likely to cause side symptoms. The difference in price is due to different manufacturing countries: Normamed is manufactured by pharmacological companies in Ukraine and Italy, and Isoprinosine is produced by Israeli companies.

Which is better: Normamed or Isoprinosine

Since the drugs are structural analogues, have an identical mechanism of action, indications and contraindications, it is difficult to say which one is better. Many patients, when choosing a drug for treatment, pay attention to its cost.

Normamed has the advantage of being able to give it to children from 1 year of age, while Isoprinosine is prescribed to such young patients in rare cases and with extreme caution. Normamed is also preferable for pregnant women, because during this period there is an exacerbation of the herpes virus due to a weakening of the immune system and complete hormonal changes. Isoprinosine is prohibited for pregnant women.

Although the indications for use of the medications are almost the same, Isoprinosine is prescribed for human papillomavirus. In this case, the medication is used as an auxiliary drug in complex therapy; Normamed does not have such an effect on the body.

Substitutes for HPV

Human papillomavirus infection is one of the most common diseases that affects the skin and mucous membranes of human organs and causes the development of severe pathologies of the genital organs and skin. There are analogs of Isoprinosine that are prescribed for HPV.

Proteflazid

The medicine is produced in the form of drops based on flavonoids of medicinal plants. The drops contain ethyl alcohol. Proteflazid is an antiviral herbal medicine, the flavonoids of which suppress viruses at the DNA level. In accordance with clinical studies, the effectiveness of the herbal medicine against the following viruses has been proven:

• adenoviruses;
• papillomaviruses;
• herpes;
• flu;
• hepatitis;
• HIV infection;
• ARVI.

Adenovirus

Proteflazide has an immunotropic effect, which restores local immunity and increases the synthesis of immunoglobulin A, alpha and gamma interferons, which contributes to increased body resistance to the invasion of viral agents.

The herbal medicine is a natural antioxidant and actively fights free radicals and toxins. The medication affects the restoration of lipid balance and also relieves the symptoms of intoxication. This medication lengthens the period of remission and prevents relapse of chronic viral pathologies.

The drug is used in the treatment of such diseases:

• herpes types 1-4;
• chicken pox;
• flu;
• cytomegalovirus and papillomavirus infections.

Chickenpox

Used as part of complex therapy:

• mycoplasma, chlamydia, ureaplasma;
• hepatitis C and B;
• HIV infections;
• AIDS.

The medication is not prescribed if you are allergic to the components in the composition, as well as with ulcerative pathologies of the digestive tract. The herbal medicine does not have carcinogenic or mutagenic properties, and is also not detected in breast milk, so taking it while feeding a child and during pregnancy is allowed only as prescribed by a doctor.

Before taking the drops, shake the liquid in the bottle well. Take the medicine 15 minutes before meals. The dosage of the drug per day directly depends on the patient’s age:

• 0-1 year – 1 drop;
• 1-2 years – 1 drop 2 times;
• 2-4 years – 2 drops 2 times;
• 4-6 years – 4 drops twice;
• 6-9 years – 9 drops 2 times;
• 10-12 years – 10 drops in the morning and before dinner;
• 12 years and older - 12-15 drops before breakfast and dinner.

Ferrovir

This medication belongs to the pharmacological group of antiviral medications. The active component in the medicine is sodium salt deoxyribonucleate, which is obtained from the extract of the milt of sturgeon and salmon fish.

The drug is an immunomodulator with an antiviral effect. The medication accumulates all the body’s protective functions against the invasion of viral and infectious agents. The drug is effective in the fight against fungi and bacteria. The active component takes part in metabolic processes at the cellular level, and also has a tropism for the hemostasis system.

Sodium deoxyribonucleate, which is its main active ingredient, has a high affinity for the organs of the hematopoietic system. In addition, it is involved in cellular metabolism.

The medication is produced in a solution for injections. The drug is prescribed as part of a combination treatment of the following diseases:

• HIV and AIDS;
• herpes and hepatitis C;
• papillomavirus infection;
• tick-borne encephalitis.

The medication should not be used if you are hypersensitive to seafood or components in the medication. It is prohibited to use Ferrovir in pediatrics, as well as in the treatment of women during pregnancy.

Dosages are prescribed by the doctor personally, and treatment is carried out on an outpatient basis or in a hospital setting.

For HIV infection and hepatitis, 5 ml should be administered intramuscularly twice a day. The maximum permissible daily dosage is up to 150 mg of the main substance. Medication course – 14 days. A repeated therapeutic course can be carried out no earlier than after 2 months. To treat encephalitis, 5 ml of the drug is administered intramuscularly twice a day. The course of therapy is up to 10 days.

The body's reactions to the administration of the drug are fever, redness and swelling at the injection site, and skin rashes.

Pharmacological group

Isoprinosine based on inosine pranobex has two main mechanisms of action - antiviral and immunostimulating. Therapy using this drug allows you to increase the body's defenses, thereby blocking the growth and reproduction of pathogenic viruses. The medicine has the ability to increase the activity of T-lymphocytes and stimulate T-helper receptors. This effect of the drug allows you to increase the production of interferon, suppress the growth of viruses, including: measles virus, cytomegalovirus, influenza strains A and B, herpes simplex virus and others.

The active component of the drug is quickly absorbed into the bloodstream, after which it has the following effect on the human body:

1. Restores the function of lymphocytes.
2. Stimulates the formation of monocytic cells.
3. Activates receptors on the membranes of T-helper cells.
4. Normalizes thymidine lymphocytes.
5. Stimulates the activity of T cells with a cytotoxic effect.
6. Increases the production of immunoglobulin G.
7. Activates the formation of interferon gamma.
8. Blocks the synthesis of cytokines.
9. Increases the synthesis of interleukin-1 and the synthesis of interleukin-2.

This principle of action of the drug allows it to be highly active in the treatment of diseases of viral origin. Isoprinosine is rapidly metabolized and excreted by the kidneys. The effect after taking the drug develops quite quickly and can be noticeable already on the 2nd or 3rd day.

Pharmacodynamics and pharmacokinetics

Isoprinosine is a complex purine derivative of synthetic origin and exhibits an immunostimulating effect and also has nonspecific antiviral effects.

The use of Isoprinosine leads to the restoration of lymphocytic function during the period of immunosuppression , increases blastogenesis in a number of monocytic cells, activates the expression of membrane receptors located on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells when exposed to glucocorticoids, and normalizes the interpolation of thymidine in them.

Inosine Pranobex stimulates the activity of natural killer cells and cytotoxic T-lymphocytes, activates the functions of T-helpers and T-suppressors, increases the production of immunoglobulin G, interleukins IL-1 and IL-2, interferon-gamma, reduces the production of pro-inflammatory cytokines - IL-4 and IL -10, enhances the chemotaxis of macrophages, monocytes and neutrophils.

Isoprinosine in vivo has antiviral activity against Herpes simplex (herpes) , measles virus , cytomegalovirus , influenza A and B, human T-cell lymphoma virus type III, human enterocytopathogenic virus, polioviruses, as well as equine encephalitis and encephalomyocarditis .

The antiviral effects of the drug are associated with inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the synthesis of some viruses. The drug also stimulates the replication of lymphocyte mRNA previously suppressed by viruses, which results in inhibition of the RNA biosynthesis of the virus itself and a decrease in the biosynthesis of viral proteins , and increases the production of alpha and gamma interferons , which exhibit an antiviral effect.

When used in combination, it enhances the effectiveness of interferon-alpha , as well as the antiviral drugs Zidovudine and Acyclovir.

After oral administration, it is well and fairly quickly absorbed from the gastrointestinal tract.

Cmax in blood plasma is observed after 1-2 hours.

It is rapidly metabolized to form uric acid and is excreted in the urine.

No accumulation of the drug in the body was detected.

The half-life for the two metabolites is 3.5 hours and 50 minutes.

Complete elimination of the drug Isoprinosine from the patient’s body occurs after 24-48 hours.

Reviews from doctors and patients

Skatov B.V., urologist, Solikamsk

Isoprinosine is a worldwide popular immunomodulator that is used in 70 countries. It was synthesized in the USA back in the late 70s. last century and has, in addition to immunostimulating, a pronounced antiviral effect. For this reason, the drug is widely used in the complex therapy of human papillomavirus infection, molluscum contagiosum, cytomegalovirus, and herpes.

This medication works where most immune drugs simply do not. Its effect on anogenital warts caused by HPV is especially valuable in complex therapy after their destruction.

Khivrich V.D., ENT doctor, Irkutsk

Isoprinosine is a good antiviral and immunostimulating drug. In my practice, I prescribe it when I am going to operate on a child for grade 3 adenoids or grade 3 hypertrophy of the palatine tonsils, and the little patient’s blood tests reveal the Epstein-Barr virus. This virus leads to increased growth of lymphoid tissue, which can lead to recurrence of adenoids after surgery. For this reason, a course of treatment with this medication is mandatory.

Irina, 34 years old, Moscow

I have been living with oncotype 4 human papillomavirus infection for 4 years now, there was a lull, and then after cystitis an exacerbation began, I was tormented by severe pain. I took Isoprinosine for six months, 6 tablets a day. After 3 weeks it became a little easier, but side effects appeared: headaches, itching and irritation on the skin. However, it helped relieve the symptoms of the disease. Now I feel tolerable, I was able to live 3 months without the drug. Now I started using it again, the headache has appeared again, but I’d rather endure these painful sensations than those caused by the disease.

The effect of the medication does not occur immediately, but after some time (about a month) and not in 1 course, you need to take it at least 2 times to see the result.

Natalya, 28 years old, St. Petersburg

Isoprinosine was prescribed by a doctor for HPV and herpes. She was examined due to infertility. They looked for the reason and could not find it for many years. Herpetic infection has been around for a long time, but in recent years it has appeared more and more often. By the time of the examination, he “popped up” every month. The doctor suggested that it could be the cause of infertility. I took the medicine for 21 days and my husband took it for 14 days. Pregnancy occurred a month after the end of treatment. I don’t know what’s going on with papillomavirus infection, but I’ve practically forgotten about herpetic infection for 4.5 years now. During this time, she already gave birth to her second child.

Miroslava, 31 years old, Rostov-on-Don

My son got sick, the doctor prescribed Normomed, I was glad that the drug was in syrup. The son did not refuse to drink. The medication helped quickly, already on the 3rd day of use the temperature subsided, all cold symptoms went away on the 6th day. Now we use this drug as an immunostimulant for the whole family in the autumn-spring period. Now this medicine is always in the home medicine cabinet.

Albina Glisic/Getty Images/Life Stic/Flickr/Indicator.Ru

Why the FDA does not approve Isoprinosine, whether it is possible to make a weapon against viruses from a derivative of a nitrogenous base, and whether it is worth taking the increase in urate levels in the blood with a bang, we tell you in the new issue of the “How are we being treated” column on Indicator.Ru.

The coming cold snap and rain may provoke a wave of colds, from which many want to protect themselves, and in the heat, doctors warn against the risk of getting sick, for example, by eating ice cream or excessively abusing the use of air conditioners. Therefore, at the request of readers, we are reviewing Isoprinosin (also known under the brands Groprinosin, Riboxin and Ribonosin), which is positioned as an immunostimulating and broad-spectrum antiviral drug. And if we have already said that all kinds of independent “stimulation of the immune system” and interference in its work are from the evil one (even if the medicine really has such an effect), then the antiviral effect is worth considering more closely.

From what, from what

Isoprinosine is based on molecules of inosine and dimepranolacedobene. These substances, according to manufacturers, should either act to stimulate the immune system, calling on our lymphocytes to work overtime, or interfere with the reproduction of viral particles that have taken over our cells.

Inosine is based on a ribose pentagon (from a sugar residue, as in our RNA), connected to a purine derivative (aromatic and imidazole “rings”; such a structure is also found in nucleotides - the “letters” of our DNA or RNA)

The authors of a 1986 review in the journal Drugs suggested that the drug does not have an antiviral effect, but does have an immunostimulating effect. The mechanism of this action, according to the same review, is unknown, and most experimental and clinical trials are preliminary, and their design leaves much to be desired.

Over the years, the situation with the mechanism has not become clearer. Inhibition of the replication of a whole list of viruses has been shown in cells (for example, in a joint study by French and American specialists, as well as in numerous studies by Polish doctors). But how does it happen? Does this effect transfer to the whole organism, and is the concentration sufficient not to poison it? How is the replication of viral DNA or RNA genome suppressed by “spare parts” for these molecules, but the replication of cellular hereditary material (sort of) is not? Considering that the cytotoxic effect was sometimes assessed simply visually, and the publications mentioned appeared in national journals and were not even translated into English, it is unknown.

New information has been added on binding sites: for example, in an article by pharmacologists from the USA and Taiwan, published in the Journal of Biomedical Science, it was suggested that inosine can act on the benzodiazepine receptor, but this is unlikely to have anything to do with the antiviral effect.

What is the status of clinical trials, clearances and approvals from leading healthcare organizations?

Not on the lists

Isoprinosine’s instructions state that the drug suppresses the activity of a number of viruses (preventing them from forcing cells to synthesize their RNA), restores the functions of lymphocytes during immunosuppression, forces some immune cells to divide and trains others to see the “target”. It is recommended to prescribe it for infection with viruses of the Herpesviridae family (the most dangerous and common of which we have already talked about, for measles, human papilloma and molluscum contagiosum (the latter is also a viral disease, the mollusk has nothing to do with it).

For adults

Therapy with Isoprinosine can be carried out for the following diseases and conditions:

1. immunodeficiency states;
2. treatment and prevention of influenza and ARVI;
3. viral bronchitis;
4. viral hepatitis;
5. chronic infections of the urinary and respiratory system;
6. sclerosing panencephalitis;
7. human papillomavirus infections;
8. human papillomavirus infection of the pelvic organs;
9. measles;
10. chicken pox;
11. radiation therapy.

The drug has found its use in the complex treatment of cancer. The drug is mainly prescribed after chemotherapy.

Substitute drugs

A direct analogue of Isoprinosine is Groprinosine, which is cheaper and is also used in the treatment of HPV. It contains the same active ingredient and in the same quantity. Groprinosin is produced by pharmaceutical companies in Poland and Hungary. However, the difference in price for a course of treatment is not significant. Manufacturers in the CIS countries produce cheaper analogues of the drug, but they are not generics of Isoprinosine.

Substitute drugs:

• "Allokin";
• "Lavomax";
• "Alizarin";
• "Hyporamine";
• "Panavir gel";
• "Tilaxin";
• "Tiloron";
• "Genferon";
• "Ferrovir";
• "Ergoferon".

Attention! Only a doctor who can comprehensively see the complexity of the development of the virus can replace the drug and prescribe its analogues.

Reviews about the treatment

Reviews from most practicing doctors are clear and indicate the effectiveness of Isoprinosine in the treatment of human papillomavirus infection. Experts note its high antiviral capabilities.

The drug smoothes out the symptoms of the disease and stops the spread of the skin and mucous membranes. The medication must be used as part of a treatment regimen that includes other medications.

Among patients, 70% of respondents speak positively about the effect of the tablets and indicate the absence of severe side effects. The number of complaints about changes in the gastrointestinal tract increases after repeated courses of therapy. Knowing this effect of treatment, doctors prescribe a group of drugs to relieve negative symptoms.

The human body is able to get along with papillomavirus. Decreased immunity provokes a surge in HPV activity. The first symptoms can be detected in the form of papillomas. In this case, you need to contact a dermatologist and monitor the behavior of the virus. Isoprinosine in combination with other medications will help cope with this problem.

pharmachologic effect

It is a derivative of purine. Inosine can be considered as a precursor to ATP. Has an anabolic effect. Activates myocardial metabolism. Inosine increases the activity of a number of Krebs cycle enzymes and stimulates the synthesis of nucleotides. Inhibits the process of destruction of the sarcolemma of ischemic cardiomyocytes and ensures intracellular energy transport. By improving microcirculation, the drug reduces the size of the zone of necrosis and myocardial ischemia.

Metabolic agent, precursor of ATP; has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. It is directly involved in glucose metabolism and promotes the activation of metabolism under hypoxic conditions and in the absence of ATP. Activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it increases the energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume. Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and gastrointestinal mucosa).

Reviews from doctors and patients

Oleg, 49 years old, therapist, St. Petersburg

There is no particular difference between Isoprinosine and Normamed. These antiviral agents are analogues and can be replaced with each other without the need to adjust the dosage. The only factors that may influence the choice of one drug over another are the presence of individual intolerance to the auxiliary components and the difference in price.

Tamara, 51 years old, pediatrician, Samara

In the treatment of viral diseases in children, I most often prescribe not Isoprinosine, but Normamed. Not to say that it is more gentle on the body. The fact is that it has a more convenient form of release - syrup, which is why it is more convenient to give it to small children. Both drugs act effectively and are well tolerated without causing adverse reactions.

Elena, 39 years old, Odessa

Isoprinosine has been saving me for many years from the manifestations of herpes on the lips. As soon as the cold season begins, ulcers appear on the lips once a month. I take Isoprinosine for prevention at the end of summer and then during autumn and winter, as soon as I feel that herpes is starting. Before taking this medicine, I drank Normamed syrup, but did not get much effect from it, and relapses occurred just as often.

Ksenia, 34 years old, Chelyabinsk

Normamed is a favorite family drug. As soon as someone in your household starts to have a cold or flu symptoms appear, a couple of tablespoons of Normamed syrup - and the disease either stops completely or proceeds mildly. Children like the syrup, it is tasty and pleasant to drink. My husband and I are treated with Isoprinosine tablets. I think it is stronger and acts faster, but for children it is quite aggressive.

Kirill, 29 years old, Khabarovsk

I had such a delicate problem as genital herpes. Initially I took Normamed, the symptoms went away quickly, but after a while the herpes returned again. I went to the doctor and he prescribed Isoprinosine. I took the pills for a few days and everything went away. Although the doctor immediately warned that herpes will not go away completely and may occur periodically. A year has already passed, and I completely forgot about the disease. Perhaps because I closely monitor my immunity and periodically take Isoprinosine for several days for prevention.

Doctors often use immune medications in their practice, such as Isoprinosine and Normomed. To choose the right medication, you need to familiarize yourself with the characteristics of the drugs.

Doctors often use immune medications in their practice, such as Isoprinosine and Normomed.

Reviews

Reviews from people who have used Isoprinosine tablets to treat viral infections are quite good. Many note that the effect of taking them was already present on the 2nd day from the moment of taking them. The drug is especially effective in the first days of illness, when the causative agents of a viral infection have not penetrated into the deep tissues of the body. Despite good reviews about the medicine, uncontrolled use of tablets can lead to negative consequences. The instructions for the drug contain all the necessary information about the drug, but it can only be taken as prescribed by a doctor.

Mechanism of action and composition

The active ingredient in the drug is inosine pranobex. According to its molecular structure, it belongs to purines - biologically active substances that catalyze (accelerate) most chemical processes in the body.

To better understand how medicine acts on the immune system and helps defeat the disease, let's remember our school biology lessons. Immunity is a unique protective system, all components of which work clearly and together. Its main task is to fight viruses and bacteria that attack our body every day.

The drug blocks the reproduction of various viruses.

One of the important links in the complex chain of immunity are T-lymphocytes, and their main type is T-helper cells. These blood cells are the first to encounter the infection and “get to know” it, reading the necessary genetic information for further destruction.

The immunostimulating effect of Isoprinosine is based on:

• stimulating the production of T-helper cells in the bone marrow and improving their ability to recognize foreign cells;
• increasing the production of interferon, a specific protein that makes the body more resistant to infections.

The drug also has antiviral properties due to:

• direct destruction of RNA viral particles;
• suppression of the processes of replication (reproduction) of viruses.

Some mothers are concerned about whether Isoprinosine is an antibiotic. No, the drug does not have antimicrobial properties, and in case of a bacterial infection (for example, sore throat), it can only be prescribed as an immunomodulator (i.e., an additional agent).

What happens in the human body during herpes?

When the herpes virus enters the body, it accumulates mainly in the nervous system. The virus remains there forever. However, under certain provoking factors, its activity increases. It is in this case that the patient discovers various cosmetic defects in the form of rashes that resemble bubbles filled with liquid.

In the human body, pathogenic flora is established due to the fact that virus particles, along with the bloodstream, are spread throughout the body. That is why herpes can be localized in a variety of organs and systems. A carrier of the herpes virus poses a potential danger to uninfected people. Pathogenic Flora can be transmitted sexually, through personal contact, through kissing and shaking hands.

When the virus enters the blood, the body's defenses begin to attack it. Thus, leukocytes prevent the proliferation of pathogenic flora in the patient’s body. But when immunity decreases, the virus takes over. In the most severe cases, the patient may even develop sepsis.

Treatment regimen for HPV with isoprinosine

Hello! Has HPV type 16 and L-SIL cervical dysplasia (HPV). There are 2 treatment regimens: Scheme 1: - Isoprinosine 28 days every day - Genferon suppositories at night - Glutoxim injections intramuscularly 10 days daily, then after 10 days 10 times every other day Scheme 2: - Isoprinosine 3 courses of 10 days from 10- daytime breaks - Genferon suppositories at night - Epigen Intim Spray 3 times a day every day Please tell me which treatment regimen is more effective (the one with isoprinosine.

I’ll say right away that I knew I had high-oncogenic HPV for a long time, since 2004. Papillomas prompted me to get tested for HPV, then I quickly cured everything with a crazy dose of prescribed medications, unfortunately I forgot the dosage and prescription. after that I had regular colposcopy and was tested for HPV (it was detected in small quantities) BUT after giving birth I developed erosion, which prompted me to retake cytology. For the first time - after childbirth, apparently as a result of the inflammatory process of reduced immunity and God knows what else, HPV blossomed in bright colors . They diagnosed dysplasia 1.

I saw a doctor and the results were positive for these 3 infections. G. said that it would be difficult for the body to treat everything at once, so let’s start with HPV, she prescribed the following treatment regimen: stage 1 1. allokin alpha (9 ampoules), unfortunately, beyond our means and I read a lot of information about this drug, they say that many Doctors prescribe them, also with a prescription, but a prescription (as I understand it) is not needed, but they put their organization there. 2. isoprinosine 2t (1000mg) 3 times a day = 9.

When a patient first came to me complaining that her vaginal discharge had a bitter taste, I thought I was working in a madhouse. - Why are you trying them? — I asked. — The doctor recommended it to me. So. The further you go, the weirder it gets. - Which doctor? - Gynecologist. Several years have passed. Now I’m very smart and immediately ask the key question: - What state did you live in? Yes, yes, don't be surprised. Tasting your own discharge is a normal recommendation for patients.

The article was written based on materials from the sites: 1papillom.ru, dermatologinfo.ru, venerologia03.ru, moidermatolog.ru, www.babyblog.ru.

Characteristics of Isoprinosine

Release form: tablets. The active ingredient is inosine. The drug restores the functioning of lymphocytes and helps increase the amount of interferon produced, which helps the body independently fight the causative agent of the virus. Indications for use:

• viral diseases - influenza, ARVI;
• herpetic infection;
• measles;
• mumps;
• chicken pox;
• hepatitis of viral origin;
• cytomegalovirus;
• in complex therapy of HPV.

Isoprinosine is taken for herpes infection, chickenpox, cytomegalovirus.

• arrhythmia;
• urolithiasis disease;
• any severity of renal failure;
• gout;
• Age contraindication: children under 3 years of age.

During gestation and during breastfeeding, taking Isoprinosine is strictly prohibited.

The drug is well tolerated, but may cause side symptoms:

• headaches with dizziness;
• nausea and vomiting;
• increased irritability and nervousness;
• drowsiness and fatigue;
• allergic manifestations on the skin.

Considering the possible occurrence of dizziness, during the period of therapy with this antiviral drug, you should refrain from driving vehicles and working with complex mechanisms. If there is no side symptom and the patient tolerates the drug well, there are no these restrictions.

Dosage for adults and children over 12 years of age: 6 to 8 tablets per day, divided into several doses. Children from 3 to 12 years: 1 tablet for every 10 kg of body weight up to 20 kg.

If a child weighs over 20 kg, he is prescribed a dosage as for an adult. The tablets can be swallowed whole or chewed if necessary. The duration of treatment is 5-14 days.

Special instructions and contraindications for the use of Isoprinosine

The ban on taking Isoprinosine applies to the following patients:

• Children under one year of age;
• Patients with gout;
• Persons diagnosed with hyperuricemia;
• Patients who have an individual intolerance to one or more components of the drug;
• Patients receiving immunosuppressant therapy.

Important: no studies have been conducted on the use of the drug during pregnancy and breastfeeding. Therefore, this drug is not prescribed to pregnant women.

Characteristics of Normamed

A drug with immunomodulatory and antiviral spectrum of action. It is produced in the form of syrup and tablets. The main component is inosine, of which 100 ml of the drug contains 5.0 g. The mechanism of action of Normamed is to destroy viruses at the DNA and RNA level, due to which the process of growth, reproduction and spread of pathogenic microflora is quickly suppressed.

Indications for use of the drug:

• viral and infectious diseases - influenza, ARVI, bronchitis, measles;
• herpes simplex virus (pathogen infection of the skin on the face, mucous membranes of the lips and mouth);
• sclerosing type panencephalitis;
• genital herpes;
• shingles;
• chicken pox;
• Epstein-Barr virus;
• mononucleosis of infectious origin;
• cytomegalovirus;
• hepatitis B viral type of chronic course;
• infectious diseases of the respiratory system in a chronic course with frequent relapses;
• other diseases that are provoked by intracellular pathogens.

Normomed is recommended to be taken for genital herpes and herpes zoster.

Contraindications for use:

• individual intolerance to individual components of the drug;
• gout during exacerbation;
• hyperuricemia;
• Age limit: children under 12 months.

It is not recommended to take Normamed during the gestational and lactation periods, but its prescription is allowed if the doctor considers that the benefits of taking it outweigh the risks of any complications. There is no evidence that the active components of the drug pass into breast milk and negatively affect the health of the newborn, but taking Normamed is not advisable during maternal feeding.

Normamed is an antiviral drug with a fairly mild effect on the body. It is well tolerated by patients, so the likelihood of adverse symptoms occurring if all dosage recommendations are followed is practically absent. Possible negative reactions of the body to Normamed:

1. Central nervous system: headaches and dizziness, fatigue and drowsiness, deterioration of general condition.
2. Digestive system: nausea and vomiting, abdominal and stomach pain.
3. Skin: allergic reactions.
4. Musculoskeletal system: pain and aches in joints and muscles.

Recommended dosage for adults: 20 ml three times a day. The dose for children is determined by weight - 1.4 ml per kilogram of body weight. The course of treatment is from 7 to 20 days, depending on the disease. Other dosages in special cases:

• mumps: 70 mg/kg body weight three times a day, course of treatment - up to 10 days;
• stomatitis: adults - 20 ml 3 times a day, children - 1 ml/kg body weight, duration - 1.5 months;
• herpes simplex and genital: 2 ml 3 times a day for 6 days, then to maintain remission - 20 ml 1 time a day for 6 months;
• Chronic infections of the respiratory and genitourinary systems: 20 ml up to 4 times a day, duration of administration - from 14 days to 12 weeks.

To achieve long-term remission, as well as for patients with immunodeficiency conditions, it is recommended to take the medicine for 3-9 weeks. The syrup should be drunk after the main meal, at the same time every day, in order to maintain a constant level of the active component in the blood.

Compound

Isoprinosine includes substances that have a beneficial effect on the body, increasing immunity and fighting the cause of the disease. The composition also includes auxiliary substances that increase efficiency, and treatment becomes possible in a short time.

So, the excipients include:

• Magnesium stearate – 6 mg is used to strengthen the central nervous system and heart. The benefits of this substance include restoration of normal functioning of internal organs.
• Mannitol – 67 mg – actively removes excess fluid from the body, and along with it harmful substances;
• Povidone – 10 mg – is used to neutralize harmful substances, that is, it has detoxifying properties;
• Starch – 67 mg – is used to saturate the body with calcium and remove harmful substances.

As you can see, each of these active and auxiliary substances of the drug has a targeted effect and does not contain side effects.