"Sirdalud": side effects, composition, application, reviews

The drug Mydocalm

Doctors prescribe this drug for:

• muscle hypertonicity;
• spasms of the spinal muscles resulting from diseases of the human musculoskeletal system: spondylosis, spondyloarthrosis, lumbar or cervical syndrome, arthrosis of large joints;
• with spasticity caused by diseases of nervous origin.
• with damage to the pyramidal tracts, cerebrovascular stroke, multiple sclerosis, etc.
• to help with rehabilitation after surgery.

The active ingredient of the drug is tolperisone chloride. Its main advantage is that it is gentle and does not have a sedative effect. In relation to Sirdalud, Mydocalm is an analogue without drowsiness.

This drug is not prescribed to children under 3 years of age. Other contraindications include myasthenia gravis and individual intolerance to the drug.

Mydocalm is produced in different forms - tablets and ampoules. 30 tablets of 150 mg each, produced in Hungary, will cost 380 rubles. The price of 5 ampoules of the drug, 1 mg each, is 520 rubles.

Action of Mydocalm

This product is available in the form of tablets and infusion solution. Its active ingredient is tolperisone hydrochloride. The list of components of the drug in soluble format includes lidocaine.

The principle of action of Mydocalm is that its active ingredient inhibits the conduction of nerve impulses, suppressing spinal reflexes. The drug reduces muscle tone. Tolperisone hydrochloride prevents the penetration of sodium and calcium into nerve cells.

The medicine is indicated for:

• increased muscle tone;
• muscle spasms occurring against the background of myelopathy, stroke, arthrosis or multiple sclerosis;
• recovery after operations on the musculoskeletal system;
• pain syndrome caused by injuries;
• diffuse scleroderma;
• Raynaud's syndrome;
• thromboangiitis;
• cerebral encephalopathy, which is accompanied by muscular dystonia.

The drug has restrictions on its use. Among them:

• epilepsy;
• myasthenia gravis;
• age less than 3 years;
• allergy to substances contained in the medication.

When taking Mydocalm, the following negative reactions may occur:

• pronounced decrease in blood pressure;
• feeling of drowsiness and weakness;
• headache;
• Digestive problems.

If there are side effects, you should stop taking the medication and consult a doctor.

When taking Mydocalm, negative reactions such as a pronounced decrease in blood pressure may occur.

These drugs are included in one pharmacological category - muscle relaxants. However, they have different compositions.

The medications have similar indications for use - they are used in the treatment of pathologies of the musculoskeletal system, as well as to speed up recovery after injuries and operations.

Medicines have not only different compositions, but also different dosages. This must be taken into account when replacing them with each other.

The daily dose of Sirdalud is determined individually. The maximum amount of muscle relaxant per day should be no more than 36 mg.

The instructions for the drug Mydocalm say that it should be taken 450 mg per day (in 3 divided doses). To check the body's tolerance of the drug, therapy should begin with a dose of 50 mg. In the absence of side effects, the dosage regimen should be gradually increased.

Pharmaceutical products also have some differences in contraindications. The drug Sirdalud has more of them. In addition, it has more side effects.

The drug Sirdalud does not contain lidocaine. Mydocalm can be used to treat children over 3 years of age, and its analogue can only be used in adult patients.

When prescribing increased dosages of the drug (to relieve severe spasms), side effects may occur more often, but this is not a reason to discontinue the drug.

3. In combination with diuretics and/or antihypertensive drugs, the drug can cause bradycardia and increase arterial hypotension.

When choosing a suitable medicine, a number of factors are taken into account - the composition, release form, dosage of the active component, type of excipients, contraindications and side effects. Pay attention to reviews, but different drugs have different effects on the body of patients with certain pathologies. If the medicine helps some, others experience side effects.

Mydocalm and Sirdalud represent the same group (muscle relaxants), but these are drugs with significant differences. The first of these has fewer restrictions on use and is characterized by a small number of side effects, but the injection solution contains lidocaine.

Sirdalud provokes the occurrence of various side effects; it is not used for a large number of pathological conditions. This drug is restricted for use in children and the elderly (under 18, over 65 years). It does not contain lidocaine, which is a plus in some situations.

The cost of both drugs is low, but Mydocalm will cost a little more than Sirdalud. Thus, the first of these medications is offered at an average price of 400–600 rubles, the second can be purchased in the range from 200 to 500 rubles.

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More than 20 years ago, a study published in the British Medical Journal was the first to describe good results for the treatment of acute musculoskeletal pain with tizanidine in combination with ibuprofen.

Tizanidine is an alpha-adrenergic agonist, that is, a substance that mimics the effect of the neurotransmitter norepinephrine on type 2 alpha-adrenergic receptors. In this way it is similar to the well-known clonidine (clonidine).

The main function of such receptors is to regulate the release of a neurotransmitter, which transmits excitation from peripheral organs to the brain. Stimulation of alpha-adrenergic receptors leads to a decrease in neurotransmitter output, thus stopping further signal transmission.

However, alpha2-adrenergic agonists also lead to other consequences in the body, for example, decreased blood pressure, weakness, bradycardia, and drowsiness. In this regard, doctors recommend taking tizanidine at night.

If Mydocalm and Sirdalud are compared by their mechanism of action, there will be a number of differences. The main component of Mydocalm, tolperisone, is a beta-amine ketone according to its chemical characteristics, and a blocker of nicotine-sensitive cholinergic receptors according to its biological characteristics.

The nerve impulse has an electrochemical basis. To implement it, it is necessary for sodium ions to penetrate into the cell through special channels in the membrane. The signal to open the channels is the binding of the neurotransmitter acetylcholine to the receptors.

It has been established that tolperisone reduces the permeability of nerve cell membranes to sodium by approximately 50%. In relation to calcium channels, it also acts as an antagonist, that is, it blocks the entry of calcium into the cell.

The first pharmacological assessment of the blocking effect of tolperisone on the central nervous system dates back to 1958. Since then, it has proven to be an excellent muscle relaxant in many randomized clinical trials.

For example, out of 250 patients taking Mydocalm for lower back pain, 225 had no pain after a week both at rest and during physical activity. The subjects tolerated the treatment well; only 5% of patients experienced side effects such as dizziness, nausea, and allergies.

Thus, an important advantage of Mydocalm is the lack of sedation when taken.

The active component of Mydocalm is tolperisone. From the chemical side, this substance acts as a beta-aminoketone, and from the biological side, it acts as a blocker of nicotine-sensitive cholinergic receptors. The effect it has is equal to Lidocaine, Novocaine and Baclofen.

The nerve impulse is based on electrochemical components. For it to pass, sodium ions must penetrate through membrane channels into the cell. In order for the channel to open, the neurotransmitter acetylcholine must bind to the receptor.

Scientists have found that the active component of Mydocalm blocks the permeability of cell membranes to sodium ions by 58 percent. It has a similar effect on calcium ions. In addition, numerous studies have shown that the use of Mydocalm has a positive effect on the condition of cell membranes.

special instructions

The simultaneous use of tizanidine-based medications and alcoholic beverages causes drowsiness and reduces the therapeutic effect of this medication. During pregnancy and breastfeeding, any analogue of Sirdalud and the drug itself are prescribed by a doctor only as a last resort. Only when the mother’s illness threatens her life. The effect of the therapeutic properties of the drug on the developing fetus has not yet been studied. It is also unknown whether the active substance of Sirdaluda, tizanidine hydrochloride, passes into breast milk. If there is a need for therapeutic treatment of a nursing mother, the question of stopping breastfeeding may be raised. How the drug will act on older children is also unknown, since there is currently insufficient clinical trial data on the effect of this drug on patients in this age group. Therefore, taking Sirdalud is contraindicated for children under eighteen years of age.

Patients who experience drowsiness or dizziness under the influence of the drug are advised to refrain from types of work that require increased concentration and quick reaction. For example, driving any vehicle or working with machines and mechanisms. Abrupt withdrawal of the drug can give impetus to the development of asthenia and cerebrovascular accident.

Prescription during pregnancy

Recommendations for the use of the medicine during pregnancy:

1. There have been no clinical trials among pregnant women, so the drug should not be taken while pregnant.
2. In some cases, doctors still prescribe Sirdalud to pregnant women, but only if the benefits from it are much greater than the potential harm.
3. The main substance of the drug can pass into breast milk, and then along with it into the baby’s body, therefore nursing mothers are prohibited from taking Sirdanul.

It is strongly recommended that women take a pregnancy test before using these tablets and only if the result is negative, start taking Sirdanul.

Mydocalm or Sirdalud which is better

Patients often ask: “Sirdulad or Mydocalm, which is better?”

Medicines have noticeable differences in price, the last of them costs almost twice as much, but there is an almost complete absence of side effects when using it. Tizanidine and Mydocalm belong to the same group of muscle relaxants, but their composition is different, which means the mechanism of action will be different. The main active ingredient of Mydocalm is tolperisone. In addition, it contains lidocaine, so the instructions for its use indicate certain restrictions on the use of the drug.

Only the attending neurologist can prescribe medications.

additional information

In clinical practice, cases of liver function disorders that were directly related to the use of this drug have been repeatedly described. Therefore, during therapy, it is recommended to periodically monitor liver parameters. If during treatment patients experience symptoms such as loss of appetite and causeless nausea, liver function indicators are analyzed much more often.

Of course, it is indicated in the instructions for use what Sirdalud tablets help with. But there is no information about analogues and costs.

Analogues of Sirdalud

They produce similar drugs in form and composition. They are similar to medicines such as Sirdalud. Cheap analogues include Tizalud and Tizanidine, which are available both in tablets and as an injection solution. There are also others:

1. "Sirdalud MR".
2. "Tizanil."

When the pharmacy does not have Sirdalud, the pharmacist usually recommends a similar medicine to the patient. Their therapeutic effect and composition are almost similar, because they contain the same active ingredient. The side effects of these medications are similar. It is also necessary to take Sirdalud analogues only on the recommendation of a doctor.

This article is not an instruction for the use of the drug "Sirdalud". Be sure to consult a medical specialist before starting to take this medicine. Do not self-medicate under any circumstances. Do not believe the stories of friends and reviews on the Internet. The drug can only be prescribed by a doctor, having previously assessed your health condition, complaints and tests. Be careful when purchasing, carefully study the instructions and composition.

Analogues substitutes

On the pharmaceutical market, muscle relaxant drugs with the active ingredient tizanidine hydrochloride, in addition to Sirdalud, are presented:

Tizalud. Manufacturer: JSC Veropharm, Russia.

A muscle relaxant drug based on tizanidine hydrochloride in 2 mg tablets.

Tizalud is a centrally acting muscle relaxant, clinically and therapeutically effective, and well tolerated by patients.

Its use is indicated for spastic conditions in skeletal muscles with pronounced pain syndrome in neurological diseases: degenerative changes, cerebrovascular accidents, multiple sclerosis, chronic myelopathies.

Tizalud is indicated for the treatment of pathologies of the spine and joints in the postoperative period (hernias, osteoarthritis).

Tizanidine

Tablets of 2 mg with the main active ingredient tizanidine hydrochloride.

Manufacturers: Berezovsky Pharmaceutical Enterprise (Russia), Teva Pharmaceutical Works Private Co (Hungary).

Instructions for use, indications and contraindications for the drug are the same as for Tizalud and Sirdalud.

The recommended initial dose of the drug is 2 mg.

Tizanil

Tablets 2,4,6 mg. Manufacturer Simpex Pharma Pvt. Ltd. (India).

Refers to central muscle relaxants, derivatives of tizanidine hydrochloride, an analogue of Sirdalud.

Relaxes the muscular system, indicated for chronic myelopathies, sclerotic changes, degenerative conditions of the spinal cord, strokes.

The muscle relaxant Tizanil is included in the complex therapy of osteochondrosis, intervertebral hernias, and post-traumatic cranial spasms.

Which muscle relaxant to use in the treatment of osteochondrosis is decided solely by a specialist.

Self-medication with muscle relaxants is strictly contraindicated and can cause irreparable harm to health!

Other foreign analogues

Modern imported close substitutes for the drug sirdalud contain the list below.

• Sirdalud MR. Tizanidine capsules with a modified release mechanism. The best imported analogue of sirdalud. Prescribed for spasms of skeletal muscles due to neurological diseases. There are contraindications and side effects. Country of origin: Switzerland, India. The average price is 560–600 rubles.
• Tizanidine Teva. Tablets are used for multiple sclerosis, myelopathy, stroke, degenerative processes in the spinal cord, and painful spasms of skeletal muscles. The drug is produced in Hungary and Israel. The average price is 135–170 rubles.
• Tizanil. The medication is sold in capsules with tizanidine as the active ingredient. Indian release product. The average price is 160–250 rubles.
• Mydocalm. The drug does not cause drowsiness as a side effect. Indications for use - increased muscle tone, spasms, organic diseases of the central nervous system, accompanied by spasms of striated muscles, with obliterating vascular diseases, Little's disease and others. Country of origin: Hungary. The average price is 340–590 rubles.

Sirdalud and its analogues are medications that should be used with caution. It is necessary to monitor compliance with the dosage and monitor for side effects.

The drug can slow down psychomotor reactions, so you should avoid driving vehicles and operating complex machinery, especially at the beginning of therapy.

Diseases for which Sirdalud is prescribed

So, why is Sirdalud prescribed? Putting aside complex medical terms, we can say that the medicine is recommended for patients with various spinal diseases. Sirdalud helps reduce spasmodic pain and relax muscles. The drug Sirdalud is most often prescribed for various spinal injuries, as well as for patients who have undergone surgery in the spinal region.

Sirdalud for back pain helps not only to eliminate symptoms, but also to remove the cause of pain - spasms.

Some forums recommend taking Sirdalud for headaches, as the drug actively relieves spasms. This use of the tablets was studied by a group of scientists who, over a year of research, came to the conclusion that the drug helps relieve headaches that are caused by tension, and also reduces spasms in chronic migraines.

How Sirdalud helps to cope with headaches you will learn from the video:

But it is worth noting that in the official instructions for Sirdalud, there are no indications for its use for headaches. This means that it is better to eliminate headaches with other drugs.

Sirdalud is also indicated for intercostal neuralgia. The drug removes the very cause of the disease - spasms, therefore it is often prescribed by doctors as the main method of treatment. Sirdalud for osteochondrosis of the cervical spine is used as a complex medicine.

The tablets reduce muscle tone, thereby reducing pain and helping in treatment.

In order to find out how to take Sirdalud correctly for osteochondrosis, you need to consult your doctor. The dosage of the drug depends on the stage of the disease and the general course of the disease.

Instructions for use

If the doctor prescribes the minimum initial dosage of Sirdalud 2 mg three times a day, then there is no risk of side effects with unwanted reactions.
The regimen of prescription and dosage of the muscle relaxant is selected by the doctor individually, taking into account the course of the underlying disease, age data, and concomitant pathologies:

1. If painful muscle spasms are pronounced - up to 4 mg three times a day.
2. Neurological disorders with spasticity of skeletal muscles - three doses of the drug, the total amount of the drug at the beginning of treatment cannot exceed a daily dose of 6 mg. Dosages of the muscle relaxant are increased by 2-4 mg evenly, at intervals.
3. To achieve an optimal therapeutic effect, the daily dosage should be 12-26 mg. Exceeding the daily amount of muscle relaxant above 36 mg is contraindicated.
4. Elderly patients are recommended to begin treatment with a muscle relaxant drug with minimal dosages, which are increased over time until a satisfactory therapeutic effect is achieved.

To avoid the risk of developing rebound hypertension with tachycardia from Sirdalud withdrawal, a gradual dose reduction is prescribed at the end of treatment.

This should especially be done in patients who have been taking Sirdalud for a long time.

If, during treatment with a muscle relaxant, the patient notices drowsiness and low blood pressure, he should refrain from work that may require concentration.

Side effects

Very rarely there may be side effects from taking the drug. They are expressed by sleep disorders, muscle weakness, insomnia, hallucinations

When treated with Sirdalud in therapeutic, prescribed dosages, side effects are rare.

They are expressed extremely moderately and are considered quickly passing .

In very rare cases, patients may complain of dyspeptic disorders, general weakness, short-term hypotension, and dizziness.

is used with caution with antihypertensive and diuretic drugs.

The combination of drugs can provoke bradycardia with arterial hypertension.

Substances that potentiate Sirdalud include sirto-containing, sedative, hypnotic and antihistamine drugs.

In smokers, the systemic bioavailability of Sirdalud is reduced by almost three times. Therefore, in this case, a higher dosage of the drug is required than the average therapeutic one.

Overdose , which can occur after taking more than 400 mg of a muscle relaxant drug, is expressed by nausea, arterial hypertension, vomiting, dizziness, impaired respiratory function, and drowsiness.

Treatment of overdose is taking enterosorbents with forced diuresis.

General characteristics of the drug

Sirdalud is produced by the Turkish pharmaceutical company Novartis Saglik Gida ve Tarim Urunlery Sanayi ve Ticaret, AS. The drug is a flat, round, white tablet with beveled edges. On the surface of each of them there is a mark and a special code that determines the concentration of the active substance in the drug (OZ - 2 mg, RL - 4 mg).

Tablets are packaged in 10 pcs. in blisters made of aluminum film and PVC. They go on sale in cardboard boxes. In each pack, the manufacturer places 3 blister packs with medicine and instructions.

The drug can be purchased at a pharmacy only with a doctor's prescription. The retail price for Sirdalud tablets varies from 220 to 360 rubles. The package with the medicine should be stored in a dark, dry place at a temperature not exceeding 25 °C

It is important to ensure that the drug is not accessible to children.

General information about the medicine

To determine why Sirdalud is prescribed, it is necessary to study in detail the description and instructions for use of the drug. All this information will help to accurately determine the patient’s need for medication and choose the most effective dosage.

Release form and composition

Pharmaceutical companies that produce Sirdalud (INN: tizanidine) offer patients only one dosage form - tablets. They have a flat, round shape and are painted white. Ten tablets are combined into strips sealed in cardboard boxes. One such package can contain up to three blisters.

The composition of this medication is also not very diverse. It includes one active ingredient and several auxiliary ones.

The correct combination of them allows you to obtain an effective medicine that will help in getting rid of some serious ailments.

One tablet of Sirdalud contains the following components:

• tizanidine (active ingredient) 2, 4 or 6 mg;
• lactose monohydrate;
• colloidal silicon dioxide (anhydrous);
• stearic acid;
• microcrystalline cellulose.

Indications

According to patient reviews, Sirdalud copes well with diseases of the spinal cord and spine. You can take it after consultation with your doctor. Only he will be able to accurately calculate the required amount of the drug and the duration of the course of treatment. If you do this work yourself, there may be a high probability of an error, which will lead to a deterioration in your health.

It is recommended to use Sirdalud to treat the following diseases:

• muscle spasms that appear as a result of diseases of the spine or after surgery;
• cervical and lumbar pain syndrome;
• spasticity (state of increased tone) of skeletal muscles;
• diseases of the muscular system associated with various neurological diseases (chronic myelopathy, multiple sclerosis; cerebral palsy);
• degenerative diseases of the spinal cord.

Main contraindications

Sirdalud, like any other medicine, has several contraindications

They should definitely be taken into account when purchasing and before use. If you neglect them, you can worsen the course of the existing disease and develop any side effects.

All this will greatly increase the recovery time, and will also make the whole process more expensive from a financial point of view.

It is prohibited to use Sirdalud tablets in the following cases:

• increased sensitivity of the body to the active substance of the drug;
• individual intolerance to one or more auxiliary components;
• severe liver diseases and disorders of its functionality;
• age under 18 and after 65 years;
• all trimesters of pregnancy;
• breastfeeding period.

In some extreme cases, the use of Sirdalud is allowed, even if the patient has one of the listed contraindications. This entire process must take place under strict dosage control and constant medical supervision.

Treatment

Therapeutic measures are aimed at reducing or eliminating pain associated with the following types of inflammation:

• with aseptic, which occurs when the structure of the spine is damaged;
• with autoimmune.

What therapy is used?

1. The most justified is the prescription of non-steroidal anti-inflammatory drugs as the main therapeutic agent.
2. In case of pain, protective muscle tension is formed, which makes it necessary to use muscle relaxants.

What effect does the main medicinal substance have?

1. A centrally acting muscle relaxant, tizanidine, causes muscle relaxation.
2. It has analgesic properties, preventing the transmission of pain impulses.
3. The original and any analogue inhibit the production of stomach acid and prevent mucosal damage associated with anti-inflammatory drugs.

Along with the treatment of dorsopathy, the original drug "Tizanidine" (analogue of "Sirdalud") is used in the treatment of the following diseases:

• myofascial syndrome;
• osteoporosis (to reduce secondary muscle tone in compression fractures);
• spastic conditions in neurological diseases.

To relieve spastic pain with the drug "Sirdalud" (instructions, analogues - their list - are available in the attachment), it is recommended to take 2 mg of the drug 3 times a day. However, based on practical experience, it is advisable to start taking tizanidine with 2 mg before bedtime. On days 3–4, the dose can be increased by 2 mg. The range of effective daily dosages is from 2 to 12 mg (optimally 6–8 mg). Sustained improvement usually occurs within a week after starting therapy.

Muscle relaxants are added to treatment if there is no effect from NSAIDs (non-steroidal anti-inflammatory drugs). The original "Tizanidine" (like all analogues of "Sirdalud") is a centrally acting muscle relaxant. In addition to relaxing muscles, it has a slight analgesic effect.

Analogs and price

Tizanil
Tizanidine

Tolperisone-OBL

Tizalud

Mydocalm

Baklosan

Baclofen

An analogue of Sirdalud in release form and composition is Tizalud. Also similar in composition is Mydocalm, which is available both in film-coated tablets and in the form of an injection solution.

Price for analogues of Sirdalud: Tizalud costs from 55 to 72 UAH; Mydocalm depending on the form of release - from 67 to 98 UAH.

Sirdalud is more of a modern drug, having a dosage form that allows it to be taken once a day, while Mydocalm has been more studied by doctors and has broader indications for use. The side effects of both drugs are similar.

The average price for 2 mg tablets is 80 UAH, the price for 4 mg is 120 UAH.

The cost in Russia of such tablets is 220 rubles. and 360 rub.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Sirdalud tab. 2mg n30Novartis Urunleri
• Sirdalud mr caps. with mod. release 6mg n30Novartis Saglik Gida ve Tarim Yurunleri Sanayi ve Ticaret A.S.
• Sirdalud tab. 4mg n30Novartis Urunleri

Pharmacy Dialogue

• Sirdalud (tab. 2 mg No. 30)
• Sirdalud (tab. 4 mg No. 30)
• Sirdalud MR (caps. 6 mg No. 30)
• Sirdalud MR (caps. 6 mg No. 30)

Europharm* 4% discount using promo code medside11

• Sirdalud 4 mg n30 tabNovartis Saglik Gida ve Tarim Yurunleri S
• Sirdalud mr 6 mg No. 30 capsNovartis Pharma AG/Novartis Sagli

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Pharmacy24

• Sirdalud 4 mg No. 30 tablets Novartis Urunleri, Turkey
• Sirdalud 2 mg No. 30 tablets Novartis Pharma S.p.A./Novartis Saglik, Gida ve Tarim Urunleri San.Ve Tik. A.S., Italy/Tureccia

PaniPharmacy

• Sirdalud tablets Sirdalud tablets. 2mg No. 30 Türkiye, Novartis Urunleri
• Sirdalud tablets Sirdalud tablets. 4mg No. 30 Türkiye, Novartis Urunleri

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BIOSPHERE

• Sirdalud 4 mg No. 30 tablet Novartis Pharma GmbH (Germany)

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This medication, like others, has its own analogues, which can be used if a person cannot use this drug for treatment for some specific reason. So, analogues of the product in question include “Tizanidine” along with “Tizanil”, “Tizalud” and so on.

Nuances of use for neurological diseases

The medicine can be used in conditions of excessive excitability of the nervous system in order to eliminate spasms with cramps and convulsions of the limbs. The drug can also be used to combat the appearance of a nervous cough and spasms of the diaphragm. The transmission of excitation through nerve cells is blocked at the level of the nervous system, which occurs thanks to intermediate spinal neurons. The effect in this case occurs quite quickly. Pathologies of spinal and cerebral origin in various forms of their manifestation can also be treated with this medication.

It is worth noting that this medicine has high bioavailability. For example, the maximum concentration in the human body occurs, as a rule, thirty minutes after using the tablet

The medicine is excreted from the body by the kidneys within one day, so it is used with great caution in the presence of nephrological diseases

It is necessary to pay attention to the fact that it is strictly forbidden to use this medication during therapy with agents that contain a substance called fluvoxamine. When a patient needs a very quick effect from using this drug, it is best to use not the tablet form, but a suspension intended for intramuscular and intravenous administration

Why Sirdalud is prescribed, you can check with your doctor.

About the drug

Not everyone knows why Sirdalud tablets help. This drug acts on skeletal muscles, and its use produces a moderate analgesic effect. The scope of application of this remedy is considered to be the presence in the body of a spastic disorder of cerebral and spinal origin. Failure can be expressed in chronic or acute form.

The drug "Sirdalud" reduces the manifestation of spasms and clonic convulsions. The active substance is absorbed fairly quickly and almost completely when taken orally. Its maximum concentration in plasma is observed, as a rule, within an hour after taking the drug. The medication is excreted in the urine.

A medical drug called Mydocalm appeared on the pharmaceutical market in Russia much earlier than Sirdalud. Both of these medications are analogues, but have completely different active ingredients. The effects of Mydocalm have now been much better studied. Like a muscle relaxant, it has a wide range of uses. But the drug "Sirdalud" in therapeutic doses causes much fewer adverse reactions in patients.

Interaction with other drugs and alcohol

The simultaneous use of tizanidine with fluvoxamine leads to a multiple increase in the first component. The result of combined use may be a clinically pronounced and prolonged decrease in pressure, leading to drowsiness, and, in addition, weakness and inhibited psychomotor reaction

Caution must be exercised when concomitantly prescribing tizanidine with other antiarrhythmic drugs (we are talking about Amiodarone, Mexiletine, Propafenone, Enoxacin, Pefloxacin, Ciprofloxacin and Norfloxacin).

The simultaneous administration of the drug "Sirdalud" with antihypertensive drugs, including diuretics, can sometimes provoke a decrease in blood pressure and bradycardia. Alcohol, along with sedatives, can enhance the sedative effect of Sirdalud. According to clinical data, the simultaneous use of oral contraceptives with tizanidine leads to a significant decrease in the clearance of tizanidine.

Interaction

Concomitant use of the drug with inhibitors of cytochrome CYP1A2 leads to an increase in plasma levels of tizanidine, which in turn leads to overdose symptoms. Simultaneous consumption of Sirdalud with CYP1A2 inducers leads to a decrease in tizanidine levels, which causes a decrease in the medicinal properties of the drug.

The use of Sirdalud together with fluvoxamine and ciprofloxacin is contraindicated. The result of simultaneous use can be a significant decrease in blood pressure, which is accompanied by dizziness and drowsiness, and in some cases, loss of consciousness.

It is not recommended to take the medicine with antiarrhythmic drugs (such as Propafenone, mexiletine, amiodarone), some fluoroquinolones (norfloxacin, enoxacin, perfloxacin), cimetidine, ticlopidine, oral contraceptives, rofecoxib.

Sirdalud should be taken with caution with drugs that prolong the QT interval (amitriptyline, cisapride, azithromycin, etc.).

The use of Sirdalurd together with rifampicin reduces the content of tizanidine in plasma and, accordingly, reduces the therapeutic effect of the drug.

Treatment of men who smoke with the drug may require an increase in dose. Alcohol should be avoided, as the medicine may enhance the negative effects of alcohol on the central nervous system. The sedative effect of Sirdalud can be enhanced by sleeping pills, sedatives and antihistamines.

As for the interaction, it must once again be emphasized that this medicine should in no case be combined with the drug Fluvoxamine. In addition, quite a lot of caution is required when combining the drug in question with such drugs as Mexiletine, Amiodarone, Propafenone, Pefloxacin, Norfloxacin, Enoxacin, Cimetidine, Ticlopidine, Ciprofloxacin”, “Rofecoxib”, as well as with hormonal oral contraceptives. In combination with diuretics or antihypertensive drugs, this drug can cause bradycardia, increasing arterial hypotension.

Instructions for using tablets

For spasms of skeletal muscles caused by neurological pathology, the dosage is selected depending on the patient’s response to the drug, and, in addition, on the severity of general symptoms:

• It is worth emphasizing that the initial dosage of this medicine is 2 mg of Sirdalud three times.
• After a few days, you can increase the dosage and take 3 or even 6 milligrams.
• The optimal daily intake is from 12 to 24 milligrams.
• Dosages above 36 milligrams per day are fraught with the development of side effects in the patient.

It is also necessary to mention the dosage for elderly patients. This is always adjusted for this category of persons. Such patients should be regularly monitored by medical personnel. Often the dose is reduced because in elderly patients renal clearance (we are talking about the rate of renal excretion of various substances from the blood) is slower. Large quantities of the drug can cause the accumulation of metabolites in the blood along with the development of an overdose and the appearance of all sorts of adverse reactions.

There are also nuances to taking this medicine in case of kidney failure. Thus, for this disease, the average dose of the drug is usually three times 2 mg of Sirdalud. Depending on the subsequent clinical picture and the general tolerability of this drug by a particular patient, the dosage with the frequency of administration is adjusted.

Doctors' opinion

Karina Bolshakova (traumatologist), 43 years old, Murom

These pharmaceutical products have the same pharmacokinetic and therapeutic profiles and are therefore interchangeable. They are available in tablet form. But in cases where you need to quickly eliminate severe pain, it is better to choose Mydocalm, because it additionally contains the anesthetic lidocaine.

Anatoly Sapozhkov (traumatologist), 32 years old, Arkhangelsk

The drug Sirdalud does not contain lidocaine, which is both its advantage and disadvantage. The advantage is that this substance helps to quickly relieve pain, but the disadvantage is that some patients are allergic to it. At the same time, Sirdalud is more often used for long-term therapy, and Mydocalm for emergency cases.

Special instructions for the use of the drug Sirdalud

Liver failure. Cases of liver dysfunction associated with tizanidine have been reported, but such cases have been rare at daily doses up to 12 mg. In this regard, it is recommended to monitor liver function tests once a month in the first 4 months of treatment in those patients who are prescribed tizanidine at a daily dose of ≥12 mg, as well as in cases where clinical signs suggestive of impaired liver function are noted - such as unexplained nausea, anorexia, fatigue. In cases where the levels of ALT and AST in the blood serum persistently exceed the upper limit of normal by 3 times or more, the use of Sirdalud should be discontinued. Renal failure. Treatment of patients with renal failure (creatinine clearance ≤25 ml/min) is recommended to begin with a dose of 2 mg 1 time per day. The dose is increased gradually, taking into account tolerability and effectiveness. If it is necessary to obtain a more pronounced effect, it is recommended to first increase the dose prescribed once a day, after which the frequency of administration is increased. After sudden drug withdrawal or rapid dose reduction, increased blood pressure, tachycardia, and other cerebrovascular disorders may occur. After prolonged use of the drug Sirdalud (especially in high doses), in order to avoid withdrawal syndrome, it is necessary to gradually reduce the dosage to stop treatment. Sirdalud contains lactose and is not recommended for patients with rare hereditary diseases - galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption syndrome. The use of the drug Sirdalud may cause a prolongation of the QT interval, especially in the case of simultaneous use of the drug with drugs that prolong the QT interval. Children. Experience with the drug in children is limited, so its use in children is not recommended. Pregnancy and lactation. No teratogenic effects were detected when tizanidine was used in rats and rabbits. Since no controlled studies have been conducted on the use of tizanidine in women during pregnancy, it should not be used during this period, unless the potential benefit to the mother outweighs the possible risk to the fetus. Animal studies have shown that tizanidine passes into breast milk in small quantities; however, it should not be used during breastfeeding. Effects on the ability to drive vehicles and operate machines. Patients who experience drowsiness should be advised to refrain from work that requires high concentration and reaction speed.

Contraindications

Contraindications to taking this drug usually include:

• The presence of severe liver dysfunction.
• Simultaneous use of the drug with Fluvoxamine.
• The presence of hypersensitivity to tizanidine or to any other ingredient of the drug.

Since there have been no controlled studies of the use of tizanidine in pregnant women, this medicine should not be used during pregnancy unless the potential benefits significantly outweigh the possible risks. The substance tizanidine is excreted in milk in small quantities. But, nevertheless, women who are breastfeeding should not use this drug under any circumstances.

Pharmacodynamics and pharmacokinetics

Absorption of the drug into the blood occurs in the proximal region of the small intestine. This process occurs quite quickly, the maximum concentration of tizanidine in plasma is observed 1 hour after its consumption. When passing through the liver, the bioavailability of the drug decreases to 34% - this is due to its pronounced metabolic properties.

At rest, binding to blood proteins is 30%. The main binding substance is albumin. Bioavailability is not related to the gender of the patient, but may vary if there are differences in the daily dose of the drug (from 2 to 20 mg.). Also, the distribution and maximum concentration of the substance in plasma will depend on this indicator.

Primary metabolism occurs in liver cells. Tizanidine is metabolized by enzymes and the cytochrome P450 system. Such processes are carried out mainly with the participation of isoenzyme 1A2. As a result, the active substances of the drug are modified into a passive form.

Sirdalud is excreted exclusively through the kidneys. Moreover, 70% of the drug is inactive metabolites, and only 2.7% of the substance remains in its original form. The half-life of the drug from the bloodstream varies from 2 to 4 hours.

It should be noted that in patients with kidney dysfunction (kidney treatment is described here), the maximum content of tizanidine in the blood exceeds the norm by almost 2 times (while maintaining creatinine clearance less than 25 ml/min.). Consequently, the elimination period increases significantly, on average this figure is 14 hours. Therefore, patients with such deviations should take the drug only in a hospital setting, and the daily dosage and overall course of treatment should be calculated individually, taking into account all the listed circumstances.

Doctor's advice Sirdalud works well, but periodically causes drowsiness and a drop in blood pressure. It is not always possible to prescribe it to older patients. If the patient spends time driving, the drug is contraindicated. In this regard, Mydocalm is safer.

Victoria DruzhikinaNeurologist, Therapist

The pharmacodynamic and pharmacokinetic properties of Sirdalud do not depend on food intake.

The concentration may exceed normal values ​​by 1/3, but this will not affect the therapeutic effect of the drug.

Pharmacokinetics of Sirdalud

When taken internally, Sirdalud is absorbed at high speed and almost completely. The maximum concentration of Sirdalud in the blood occurs after 8 hours. Bioavailability due to pronounced metabolism and passage through the liver is about 34%.

Sirdalud is released from the drug capsule over a long period of time, which softens the pharmacokinetic profile and ensures the stability of the therapeutic concentration of the drug in the blood for 24 hours.

According to laboratory reviews, Sirdalud is quickly and with a high percentage metabolized in the liver.

It is excreted primarily through the kidneys, on average after about 3 hours. About 70% of the dose taken is excreted in the form of metabolites, about 2.7% of the substance remains unchanged.

The patient's gender does not affect pharmacokinetics.

In case of renal failure, the maximum plasma concentration increases approximately 2 times, and the half-life increases to 14 hours.

As with Sirdalud analogues, food intake does not affect the pharmacokinetics and does not change the absorption of the drug.

Pharmacological effects of the drug

The substance tizanidine is primarily a centrally acting muscle relaxant. The base point of application of its influence is located directly in the spinal cord. This medication stimulates presynaptic receptors by inhibiting the release of the excitatory amino acid that stimulates methyl and aspartate. As a result of this effect, polysynaptic transmission of excitation at the level of spinal cord neurons is suppressed in the body. Since it is this mechanism that is responsible for excess muscle tone, against the background of its suppression it decreases. In addition to its muscle relaxant properties, tizanidine may also have a mild central analgesic effect.

It is worth noting that the drug "Sirdalud" is very effective for acute painful muscle spasms, as well as for chronic spasticity of cerebral and spinal origin. This drug reduces the manifestation of clonic convulsions, as a result of which the resistance to passive movement decreases and the volume of active actions increases. The muscle relaxant effect, along with the adverse reactions of the drug, directly depend on the concentration of the drug in the patient’s blood plasma. Next, we will find out for what purposes doctors usually prescribe this medication to their patients.

What are the tablets "Sirdalud" for?

Let's take a closer look at this issue. Indications for its use are:

• The patient has spasticity of skeletal muscles caused by a neurological disorder. This may be cerebral palsy along with degenerative pathologies of the spinal cord, multiple sclerosis, problematic cerebral circulation, myelopathy, and so on. Indications for the use of Sirdalud tablets must be strictly observed.
• The occurrence of functional diseases of the spinal column.
• As part of the postoperative period for recovery after surgery, for example, after surgery to eliminate a herniated disc.

Indications for use of the drug "Sirdalud" are described in the instructions.

Indications for use

The appointment of Sirdalud is justified if it is necessary to relax smooth skeletal muscles and relieve cramps and spasms .

An important feature of Sirdalud: along with the fact that the drug provides effective relaxation of the spinal cord, it does not negatively or depressingly affect the functioning of the central and autonomic nervous systems.

Indications for the use of the muscle relaxant Sirdalud:

• postoperative period (intervertebral hernia);
• recovery period after spinal injuries with injuries of large joints;
• chronic myelopathic conditions;
• ischemic, hemorrhagic strokes in brain tissues and membranes;
• convulsive syndrome;
• nervous cough, spastic diaphragm;
• multiple sclerosis with cerebral palsy;
• diseases of the spine.

Possibilities of clinical use of the drug

Diseases of the spine and joint pathology for which the drug Sirdalud is used:

1. osteochondrosis;
2. radiculitis;
3. dystrophic and degenerative pathology of intervertebral discs;
4. age-related pathologies associated with impaired blood supply to the intervertebral discs and joints;
5. arthritis, arthrosis;
6. static, functional pathologies of vertebral structures: cervical-brachial, posterior cervical-sympathetic syndromes.

Composition and pharmaceutical properties

The main active component of the drug Sirdalud is tizanidine hydrochloride. Once in the body, this compound stimulates presynaptic α2 receptors and blocks the release of excitatory aminocarboxylic acids. As a result, in a person who has taken the pill, the polysynaptic transmission of nerve impulses at the level of interneurons of the spinal cord is suppressed and muscle tone is significantly reduced. Along with the muscle relaxant effect, tizanidine hydrochloride exhibits moderate analgesic properties.

In addition to the active component, Sirdalud includes a complex of auxiliary compounds. Among them: microcrystalline cellulose, colloidal silicon dioxide, lactose and stearic acid.

Application of Movalis

The drug is attracted by its good absorption: when taking tablets, the bioavailability of the drug is about 80-90%.

The main active ingredient is meloxicam. The product has a high selectivity of action and acts at the destination, causing little damage to the gastrointestinal mucosa. Metabolic products are completely excreted mainly through the urinary system, with feces no more than 5-6%. The elimination period of the drug is about 20-24 hours.

Movalis or its substitutes are prescribed as a symptomatic remedy for the following diseases:

Rheumatoid arthritis;

Spondylosis;

Degenerative changes in joint tissue.

The daily dose should not exceed 7.5 mg; in adolescents, the dose is calculated at 0.25 mg per 1 kg of body weight.

The cheapest similar products

The foreign drug Sirdalud has a fairly high price, so most patients prefer to be treated with analogues of Sirdalud, which are cheaper than the original drug.

Tizalud

Sirdalud substitute Tizalud is made in tablets with the active ingredient - tizanidine. The medication is used to reduce tone and tension in skeletal muscles, which are provoked by neurological pathologies:

• multiple sclerosis;
• ischemic stroke;
• myelopathy in chronic form;
• degenerative pathologies of the back;
• postoperative period of surgical treatment of the spine.

Multiple sclerosis

Tizalud is not used in the treatment of patients with allergies to the composition of the drug, as well as for liver pathologies. Due to the lack of information about the safety of the medication, it is not recommended for use by women during the lactation period, during pregnancy, and for the same reason it is not prescribed to children.

It is necessary to discontinue the medication gradually, reducing the dose. If you cancel quickly, you can provoke the following violations:

• tachycardia;
• hypertension and the occurrence of recurrent stroke.

Therapy begins with a dosage of 2 mg and is gradually increased to a therapeutic dose of 4 mg. When reducing muscle cramps and spasms, the average dosage in treatment is 2-4 mg. Also, in severe cases, you can take another dose of 2-4 mg before bed.

When treating spasticity caused by neurological disorders, the doctor selects the dose personally. You need to start treating spasticity with a dosage of 6 mg, and within a week reach a dosage of 12-24 mg.

Adverse reactions:

• drowsiness;
• dizziness and headache of varying intensity;
• hallucinations;
• confusion and disorientation in time and space;
• hypotension;
• bradycardia;
• fainting and shortness of breath;
• abdominal pain and diarrhea.

Tizanidine

Tizanidine is produced by Israeli and Russian pharmaceutical companies. The Russian substitute for Sirdalud is much cheaper than the Israeli substitute. Tizanidine is prescribed for the following disorders in the central nervous system:

• local muscle cramps due to neurological disorders;
• seizures in multiple sclerosis;
• pathologies caused by degenerative changes in the spinal cord;
• chronic convulsive spasms.

The drug should not be prescribed during pregnancy, childhood or when breastfeeding a newborn, and it is also prohibited to use it in patients with the following pathologies:

• sensitivity to components;
• liver pathologies;
• asthenic palsy of the bulbar type;
• therapy with Ciprofloxacin.

Asthenic bulbar palsy

It is necessary to take the medicine without becoming attached to eating food. You need to start treatment with a dosage of 2-6 mg three times a day. The permissible daily maximum is 6 mg. The dosage is increased gradually from the minimum, and the drug is also gradually discontinued.

The therapeutic effect is achieved with a dosage of 12-24 mg, distributed over 3-4 doses. The permissible maximum of medication per day for the treatment of spasticity is 36 mg. The duration of the medication course is determined by the doctor personally. For liver and kidney pathologies, minimal dosages are prescribed and it is recommended to start therapy with a dose of 2 mg once a day.

Adverse reactions of the body after therapy with Tizanidine:

• drowsiness or insomnia;
• dizziness and headache of varying intensity;
• hallucinations and sleep disturbances;
• confusion;
• bradycardia and a sharp decrease in pressure - hypotension;
• fainting and shortness of breath;
• abdominal pain, nausea, gastralgia, vomiting and diarrhea;
• hepatitis;
• muscle weakness;
• increased transaminases.

Characteristics of Sirdalud

The active component of this muscle relaxant is tizanidine. The medicine inhibits the process of nervous excitation and the release of amino acids, and also affects neuromuscular transmission and the condition of the spine.

The remedy is indicated in the following situations:

• muscle spasms due to spondylosis, osteochondrosis of the cervical spine;
• recovery after surgical interventions on the back and other parts of the musculoskeletal system;
• muscle spasms caused by dysfunction of the central nervous system and brain.

It is forbidden to use Sirdalud if liver function is reduced, if you are a minor, or if you are allergic to substances from its composition. During lactation and pregnancy, using the medication is also undesirable, because

Clinical studies of the drug's effects on fetal development have not been conducted. During pregnancy, the drug can be prescribed only for exceptional indications and under close medical supervision.

The medicine has a prolonged effect, but it has a number of side effects. It calls:

• overdrying of the mucous membranes of the mouth;
• the occurrence of hypotension and bradycardia;
• hepatitis;
• feeling drowsy;
• muscle weakness;
• sleep disorders;
• dizziness;
• visual and visual hallucinations;
• digestive disorders in the form of nausea and vomiting.

It is forbidden to use Sirdalud if liver function is reduced, if you are a minor, or if you are allergic to substances from its composition.
Long-term use of the drug may cause decreased vision and poor concentration.

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Analogues in tablets

Most often, analogues of Sirdalud in tablets are used in outpatient treatment of patients. These remedies are less effective than injections, but last longer.

Miolastan

Substitute for Sirdalud Miolastane is a centrally acting muscle relaxant medication with the active ingredient tetrazepam. Medicine is prescribed to eliminate muscle spasms in various pathologies:

• radiculitis and multiple sclerosis;
• degenerative disorders of the spine;
• paralysis of cerebral etiology;
• myelopathy, neuralgia and arthralgia.

Radiculitis

Prescribed with great caution in the 2nd and 3rd trimester of pregnancy, in pediatrics. The drug is not prescribed for:

• allergies to components;
• myasthenia and porphyria;
• lactation;
• in the 1st trimester of pregnancy.

Dosages depend on the method of treatment. In a hospital setting, the doctor prescribes the maximum dosages allowed for therapy, and for outpatient treatment, the dosages are halved to avoid the development of severe side effects:

• The initial dosage in the hospital is 50 mg, after which I gradually increase the dose by 50 mg until a therapeutic dosage of 150 mg is reached three times a day. The permissible stationary dosage per day is 300-400 mg;
• An outpatient course of treatment begins with a dosage of 25 mg and is gradually increased by 25 mg. Therapeutic dosage is 75-100 mg.
• elderly patients need to reduce outpatient treatment doses by half;
• in rare cases, children are prescribed 4 mg on an outpatient basis. This dosage should be divided into 3-4 doses.

Negative reactions of the body to the drug:

• anorexia;
• drowsiness;
• myasthenia gravis;
• aggressiveness;
• euphoria;
• ataxia;
• skin reactions - rash and itching of the skin;
• tremor;
• myoclonic convulsions - after abrupt discontinuation of the drug.

Sirdalud substitutes in ampoules

Analogs of Sirdalud, produced in solution for injection, are more effective and faster than the tablet product. The injection solution is more often used in hospital settings to relieve acute pain and spasms.

Mydocalm

Mydocalm pilyule_ana-051 is produced in a solution for injections and in tablets with the active main component - tolperisone. It is a muscle relaxant that reduces muscle tone. The drug has an affinity for nerve fiber tissue.

Its highest concentration is achieved in the neurons of the spinal cord, in the brain stem, in the peripheral parts of the nervous system, as well as in all endings and nerve centers. Most often, the medication is prescribed to block the transmission of impulses along the reflex pathway in the brain regions of the back. This inhibition provides the muscle relaxant effect.

Action of Mydocalm

The chemical formula of the drug is very similar to the formula of Lidocaine. Just like Lidocaine, Mydocalm is a membrane-stabilizing drug that inhibits the activity of sodium channels and the overexcitability of neurons in afferent fibers. The medication blocks the release of transmitters and also acts as an antagonist of alpha-adrenaline receptors.

Mydocalm solution is used for spasticity of the muscular system, as well as for spasticity in the post-stroke period, at a time when treatment with injection of medication is preferable.

https://youtube.com/watch?v=kIsWPDOe2BQ

Mydocalm should not be used if the patient has:

• allergy to medicine;
• myasthenia gravis;
• childhood;
• 1st trimester of pregnancy;
• lactation period.

The solution is used only in the treatment of adult patients. The solution is administered intravenously or intramuscularly. Dosage per day for intramuscular use is 100 mg twice a day, or by slow injection into a vein 1 time 100 mg. The duration of the medication course is determined by the doctor based on the positive dynamics in treatment.

The side effects of the drug on the body are quite severe and affect all systems and organs, so its use for self-medication is prohibited.

Tolperil

Tolperil belongs to the pharmacogroup of muscle relaxants that have a central effect on the nervous system. The effectiveness of the drug is ensured by the components - lidocaine and tolperisone. The medication is a membrane stabilizer for spinal neurons and receptors. The drug also has an anesthetic effect at the site of damage to muscle tissue and nerve endings.

Tolperil blocks calcium channels and the entry of calcium ions into muscle and nerve fibers, which leads to increased blood flow to the peripheral parts, to the brain cells of the head, which helps reduce the rigidity of muscle tissue and the manifestation of an antispasmodic effect. Lidocaine blocks sodium channels, which provides a rapid anesthetic effect.

The medicine is not prescribed to children under 18 years of age, if they are allergic to the composition of the medicine, or if they have myasthenia gravis. During the lactation period, taking the medication is possible after transferring the child to feeding with artificial formulas. You can also use the medicine under medical supervision in the 2nd and 3rd trimester of pregnancy.

The duration of therapy is prescribed by the doctor personally to each patient. Dosages of drug administration:

• 100 mg is administered intramuscularly 2 times a day;
• IV – 1 time per day 100 mg.

It is possible that after taking the medication the following side symptoms may occur:

• anemia;
• tremors of limbs and convulsions;
• anorexia;
• headache, sleep disturbance (insomnia);
• depression;
• paresthesia;
• heart rhythm disturbances - arrhythmia, tachycardia;
• arterial hypotension;
• disorders in the digestive tract.

pharmachologic effect

Tizanidine is an alpha2-adrenergic receptor antagonist that reduces the tone of muscle fibers of skeletal muscles. The key site of action of Sirdalud is the spinal cord. Its components interfere with the release of amino acids that affect the activity of NMDA receptors. Inhibition of polysynaptic impulse transmission pathways at the level of interneuron connections leads to a decrease in muscle tension and, as a result, elimination of symptoms of hypertonicity of muscle fibers.

The muscle relaxant has a pronounced analgesic effect. It is used to relieve severe pain during the development of acute or sluggish spastic pathologies of spinal or cerebral etiology. When using the tablets, clonic spasms, as well as the frequency of seizures, are reduced.

The drug is not combined with CYP1A2 inhibitors due to increased serum concentrations of tizanidine. An increase in the level of active components in the bloodstream is fraught with overdose and the occurrence of undesirable effects, as well as an increase in their half-life.

Due to the possible development of bradycardia, arrhythmia and other complications, it is not recommended to combine a muscle relaxant with:

• inducers of CYP1A2;
• antihistamines;
• oral contraceptives;
• antiarrhythmic tablets;
• fluoroquinolone antibiotics;
• antihypertensive drugs;
• antipsychotics.

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The combined use of an alpha2-adrenergic receptor antagonist with centrally acting medications and narcotic analgesics is fraught with increased sedative effects. Due to the high likelihood of an addictive antihypertensive effect, it is prohibited to combine tablets with other adrenergic receptor antagonists.

Pharmacological group

Sirdalud price

You can buy Sirdalud in online pharmacies or regular departments by presenting a prescription to the pharmacist. The cost depends on the selected concentration of tizanidine in tablets and the accepted level of markup in the retail outlet. Approximate prices are listed below:

Pharmacokinetic properties

Sirdalud is absorbed into the blood plasma through the small intestine. The peak serum concentration of tizanidine is observed 50-60 minutes after taking the tablets. More than 34% of medicinal components are metabolized in the liver. Gender does not in any way affect the pharmacokinetic properties of the alpha2-adrenergic receptor antagonist.

The half-life of medicinal breakdown products averages 3 hours. At least 70% of metabolites are eliminated by the kidneys, the remaining part is excreted unchanged in bile along with feces. If glomerular filtration is impaired, the average plasma level of tizanidine increases by 2 times. In patients with renal failure, the half-life of the drug's metabolites increases to 11-14 hours.

Consumer Reviews

Six months ago I began to experience nagging pain in my back and morning muscle stiffness. The doctor I turned to for help diagnosed me with myelopathy and recommended that I undergo a course of therapy using the muscle relaxant Sirdalud. I started taking this drug 1 tablet (2 mg) three times a day.

The effect of the treatment appeared on the third day. The pain and constant feeling of fatigue disappeared, and my mood improved. I had no side effects from taking the medicine; on the contrary, I began to feel much better. Therefore, I can confidently recommend Sirdalud to all those who have the same back problems.

Elena Vitalievna, Moscow

A very good drug. With its help I got rid of pain in the cervical spine. I was especially pleased with the price of these tablets - I paid about 500 rubles for 2 packs. My rating for Sirdalud is 5 out of 5.

Sergey, St. Petersburg

I used Sirdalud in the complex treatment of osteochondrosis several years ago.
The tablets perform their functions perfectly. However, they have one significant drawback - after taking them you really want to sleep, you feel weak throughout your body. I work as a driver, so I had to stop using this medicine and replace it with an analogue. Anton Anatolyevich, Volgograd

Side effects of drugs

Sirdalud or Mydocalm have side effects. Therefore, before saying which of these drugs is better, factors must be taken into account. The negative effects of each drug are listed in the table.

Description of the drug

Sirdalud is a drug that suppresses the transport of excitation of spinal cord neurons through the polysynaptic pathway, due to which rapid muscle relaxation is observed.

The drug is prescribed as a pain reliever for the following problems:

• spinal injuries;
• intercostal form of neuralgia;
• osteochondrosis in the cervical region;
• cerebral paralysis;
• multiple sclerosis;
• problems with blood circulation in the brain area;
• chronic form of myelopathy;
• degenerative diseases of the spinal cord;

Also, the drug is prescribed in case of pain, during the recovery period after undergoing surgery.

The dosage of the drug is selected taking into account the severity of the disease on an individual basis. On average, the initial dose of a prescribed drug is 6 mg of tizanidine (the main active ingredient) per day. The presented amount of product is divided into 3 doses. The maximum permissible dose of the drug per day is 36 mg of tizanidine.

The drug is strictly contraindicated for use in the following situations:

• the period of bearing a child and breastfeeding;
• age under 18 years;
• the presence of severe liver failure;
• the presence of an allergic reaction to any of the components present in the medicine.

The main active ingredient of the drug Sirdalud is tizanidine, which has the ability to reduce skeletal muscle tone, thereby effectively relieving muscle spasms. Sirdalud is a muscle relaxant that promotes effective muscle relaxation by suppressing the transmission of excitation of spinal neurons through the polysynaptic pathway.

Tizanidine also has a central analgesic effect and is successfully used for acute and chronic diseases of the spinal and cerebral nature.

The drug is well absorbed into the systemic bloodstream from the stomach, reaching peak concentrations an hour after taking the tablet. The metabolic processes of Sirdalud occur in the liver with the formation of inactive metabolites. A small proportion of the drug is excreted unchanged, and the majority is excreted as breakdown products. This happens with the help of the kidneys.

The drug is available in tablets and capsules containing two, four or six milligrams of the active substance.

By the way, in the United States such medicine is considered a narcotic drug and is prohibited from public sale. Americans believe that Sirdalud causes drug addiction, and therefore the patient must be under the constant supervision of the attending physician. However, our experts say the opposite, so this medication can be purchased from us at any pharmacy without a prescription.

The drug is used to relieve pain symptoms in various diseases of the spine and skeletal muscles:

• for spinal injuries;
• intercostal neuralgia;
• osteochondrosis of the cervical spine;
• cerebral palsy;
• multiple sclerosis;
• cerebrovascular accidents;
• chronic myelopathy;
• degenerative diseases of the spinal cord;
• for painful muscle spasms in the postoperative period.

It is worth noting the fact that Sirdalud not only relieves pain, but also helps eliminate the very cause of pain.

The doctor should select the appropriate dosage of the medicine and the treatment regimen, based on the severity of the disease and its type, as well as depending on the individual characteristics of the patient’s body.

Typically, the starting dose is about six milligrams of tizanidine per day, divided into three doses. With a good response, the dose is gradually increased, bringing it to the therapeutic dose, which ranges from 12 to 24 mg per day. The maximum daily dose is considered to be 36 mg of tizanidine.

Contraindications to the use of the drug are:

• period of pregnancy and lactation;
• childhood and adolescence up to 18 years;
• severe liver failure;
• hypersensitivity to any components included in the drug.

The drug should be prescribed with caution to elderly people and patients with any forms of renal failure. It is also strictly forbidden to use Sirdalud simultaneously with fluvoxamine or ciprofloxacin, since such an interaction can provoke an overdose of tizanidine. In this case, a dose exceeding 400 mg of the substance is fatal. Symptoms of overdose are:

• significant decrease in blood pressure;
• weakness, drowsiness;
• nausea and dizziness;
• respiratory dysfunction;
• respiratory collapse and coma;
• inhibition of mental and physical reactions.

If any negative symptoms appear, repeated gastric lavage, forced diuresis and constant use of sorbents, including activated carbon, are necessary.

When taking this medication, some adverse reactions occur, usually expressed in:

• dyspeptic disorders;
• increased activity of liver enzymes;
• nausea and vomiting;
• weakness, dizziness, drowsiness, dry mouth;
• arterial hypotension and slow heart rate;
• insomnia, sleep disorders, hallucinations and muscle weakness;
• acute hepatitis.

How to take Mydocalm and Sirdalud

Drugs that are part of the group of central muscle relaxants enhance each other’s effects. This means that when Mydocalm, Sirdalud and Baklosan are taken simultaneously, the transmission of nerve impulses may be significantly disrupted, which will lead to limitation of motor activity. Muscle relaxants of this group in large doses affect the diaphragm.

Both drugs are centrally acting muscle relaxants and have the same effect on the body. They can be prescribed simultaneously, but this must be done by the attending physician.

Mydocalm tablets are prescribed in dosages that depend on the patient’s age and range from 5 to 150 mg per day. The solution for intramuscular injections is administered at 100 mg 2 times a day, and intravenous injections at 100 mg 1 time a day.

Sirdalud tablets are taken after meals. The dosage is prescribed by the doctor: 2-4 mg 3 times a day. If necessary, increase the dose. The maximum daily dose is 36 mg.

Reception scheme

According to the instructions for use, Sirdalud tablets are taken orally. The drug is taken with a sufficient amount of liquid (more than 100 ml). For painful muscle spasms, patients are prescribed 2-4 mg of tizanidine three times a day. In severe clinical cases, the patient can take an additional dose of the drug (2 mg) before bedtime.

For spasticity of skeletal muscles that occurs against the background of neurological pathologies, patients are prescribed 2 mg of tizanidine 3 times a day. Every 5-6 days the dose of the drug is increased by 2-4 mg. In most cases, the optimal therapeutic effect can be achieved by taking 12-24 mg of the active component of the drug within 24 hours.

Systematic excess of recommended doses of Sirdalud can cause dizziness, vomiting, nausea, daytime drowsiness, increased anxiety, disturbances in the functioning of the respiratory system, sharp constriction of the pupils and decreased blood pressure. Patients who show signs of overdose are advised to temporarily stop using the medication and undergo a course of symptomatic treatment, including taking diuretics and activated charcoal.

Reviews for Sirdalud

Reviews of Sirdalurd tablets are left by patients of different ages. The average rating on the forums for this medicine is 3.9 points out of 5. Many patients note the occurrence of side effects such as drowsiness and fatigue. There are also reports of the drug's effect on the liver.

Reviews from doctors about Sirdalud: the drug is used for symptomatic treatment, it helps reduce spasms of the skeletal muscles. If side effects are severe or there is no result after 3 days of taking the medication, you must contact your doctor to adjust the treatment regimen.

Analogs

Based on the combination of active substances and pharmacological effect on the body, the following well-known analogues of Sirdalud, produced in the form of tablets by domestic and foreign manufacturers, are distinguished:

• Tizanidin-Teva;
• Tizalud;
• Tizanil;
• Tizanidine;
• Baclofen;
• Miaxil;
• Mydocalm;
• Midostad;
• Tolperil;
• Miorix;
• Myoflex;
• Muskomed.

Mydocalm or Sirdalud

A well-known analogue of the drug is Mydocalm, also a centrally acting muscle relaxant that relieves muscle spasms. The drugs differ in their active substances - the analogue contains tolperisone. Mydocalm tablets are available in dosages of 0.05 or 0.15 g of the active ingredient. Tizanidine is an alpha-adrenergic agonist, similar in action to clonidine, causing drowsiness. Tolperisone is a beta-aminoketone, similar in effect to novocaine, but does not have a sedative effect. In terms of cost, Sirdalud is 40% cheaper.

Overdose

There is information about side effects when the recommended dose is significantly exceeded (400 mg). In case of overdose, dyspeptic disorders, miosis, a sharp drop in blood pressure, dyspnea and coma develop.

Patients with overdose are advised to administer sorbents, forced diuresis and symptomatic treatment.

If more than 40 mg of tizanidine is taken, patients develop an overdose, the manifestations of which may include:

• respiratory distress;
• decrease in blood pressure;
• nausea;
• gagging;
• drowsiness;
• anxiety;
• bradycardia;
• paralytic miosis;
• dizziness.

To quickly remove drugs from the body, it is recommended to take activated charcoal. If your health worsens, forced diuresis is indicated.

Combination of Sirdalud with alcoholic drinks

Alcohol is also considered an antidepressant and has a depressant effect on the nervous system; the main processes in the body slow down greatly. The drug in question has an identical effect on the human body.

That is why when combining alcoholic beverages and medicine, there is a double load on the nervous system. The breathing process is severely inhibited, which provokes the occurrence of coma, the consequence of which can be death.

Therefore, there is no need to once again subject a weakened body to such a load that it simply may not be able to cope with.

A combination with alcoholic drinks may be less tragic, but this union will not bring any positive effects for the patient. Ethanol, which is present in wine and vodka products, greatly reduces the effect of the drug. Therefore, its use becomes simply impractical, because it does not cure and cannot in any way rid the patient of the disease, but, on the contrary, provokes a lot of not the most pleasant complications.

The combination of alcohol and Sirdalud has a negative effect on the kidneys

We must not forget that the drug Sirdalud has a negative effect on the liver. And if, at the time of taking the medicine, you also start drinking alcohol, then the death of living cells is provoked, due to which tissues subsequently die and necrosis begins to form. If you do not stop combining these components at this stage, the drug will not only cease to have a therapeutic effect, but will also cause the development of liver failure.

In addition, the combination of Sirdalud and alcoholic beverages also has a negative effect on the kidneys. The simultaneous use of these drugs puts a significant burden on the organ, forcing it to function under wear and tear. Dehydration occurs because almost all fluid reserves are spent on eliminating toxins.

With systematic overload in the kidneys, an inflammatory process occurs, a violation of mineral metabolism is observed, urolithiasis and urolithiasis are formed. If you do not stop combining alcoholic beverages and Sirdalud at this stage, the development of renal failure is possible.

In people suffering from alcoholism, the use of this drug provokes the formation of bone demineralization, which is characterized by the leaching of calcium, phosphates and magnesium from the body. There is a sedimentation of these minerals in the kidney tissues, which is a clear prerequisite for urolithiasis.

When drinking alcohol and Sirdalud, a constant feeling of drowsiness and weakness occurs

Among the main consequences that can befall a patient as a result of combining alcoholic beverages and medications are the following:

• a significant decrease in blood pressure down to critical levels;
• feeling of constant weakness and drowsiness;
• feeling of nausea and dizziness;
• manifestation of pathologies of the respiratory system;
• inhibition in actions and thinking.

Considering the compatibility of Sirdalud and alcoholic beverages, we can confidently say that combining these components is strictly prohibited. This is primarily due to the fact that painkillers and sedatives affect the central nervous system in a similar way to alcohol.

Alcohol, which is to some extent an antidepressant, has a depressant effect on the nervous system, causing a slowdown of all reactions present in the body. Sirdalud has completely similar actions. As a result of a double load on the central nervous system - depression of respiratory functions, collapse in the respiratory tract, coma and even death.

The combination of Sirdalud with alcohol may be less dangerous, but still will not bring any positive effects. For example, ethanol has the property of reducing the effect of various drugs, as a result of which the use of the drug will not help in any way to get rid of the disease, and the lack of quality treatment can provoke the development of a number of complications.

In addition, we should not forget the fact that Sirdalud has a rather negative effect on the liver; if at this moment you also start drinking alcohol, the death of hepatocytes will begin, and as a result, the death of liver tissue will occur or necrosis will form. Even if you do not stop combining the presented components at this stage, you cannot avoid the development of diseases such as hepatitis and even cirrhosis.

For people who have impaired liver function or those who suffer from alcoholism, combining Sirdalud with alcoholic beverages is strictly prohibited, since several days of regular combination of components and the development of death are almost impossible to avoid.

Another consequence of combining alcohol with the presented drug is an increase in the side effects inherent in the latter:

• lowering blood pressure to a critical level;
• strong feeling of weakness and drowsiness;
• feeling of nausea and dizziness;
• development of pathologies of respiratory processes;
• development of respiratory collapse;
• the occurrence of inhibition in terms of physical and mental reactions.

Release form and composition

Sirdalud is available in the form of tablets: white or almost white, flat, round, with beveled edges, with a score (2 mg tablets) or crossed marks (4 mg tablets) on one side and the code OZ (2 mg tablets) or RL (tablets 4 mg) to another (10 pieces in blisters, three blisters in a cardboard pack).

Composition of 1 tablet:

• active ingredient: tizanidine (in the form of tizanidine hydrochloride) – 2 mg or 4 mg;
• auxiliary components: lactose monohydrate, stearic acid, microcrystalline cellulose, anhydrous colloidal silicon dioxide.

Nosological classification (ICD-10)

A centrally acting muscle relaxant is used in the treatment of diseases caused by pathological neurophysiological reactions:

• G35 is a chronic autoimmune disease accompanied by damage to the brain and spinal cord (multiple sclerosis);
• G80 - pathologies of the central nervous system caused by damage to the tissue of one or more parts of the brain (cerebral palsy);
• G95.9 - degenerative processes in the spinal cord of unspecified etiology (myelopathy);
• I69 - complications of cerebrovascular pathologies;
• M16 - osteoarthritis of the hip joints;
• M42 - degenerative changes in the joints of the spinal column (osteochondrosis);
• M54.1 - radicular syndrome;
• M54.3 - compression or inflammation of the sciatic nerve;
• M54.4 - lumbago in the lower back, caused by damage to the sciatic nerve;
• R25.2 - paroxysmal muscle contraction.

Synonyms of nosological groups

The shelf life is 3 years.

Differences

When prescribing medications, their mechanism of action and indications for use are taken into account. These medications are used to treat the same diseases. But there are differences between the drugs. Sirdalud is prescribed for the treatment of cerebral and spinal diseases. The active component quickly eliminates pain, cramps, and improves contractions of skeletal muscles.

The drugs also differ in their contraindications.

Both medications are not prescribed:

• with drug intolerance;
• children;
• elderly;
• if you are allergic to lactose;
• pregnant women.

Mydocalm, in addition, is not prescribed for myasthenia gravis. There are differences in methods of application.

Sirdalud has a greater number of negative effects:

• drowsiness;
• hypotension;
• dizziness;
• bradycardia and others.

Mydocalm can cause headaches and gastrointestinal disturbances.
And Mydocalm can cause headaches and gastrointestinal disturbances. Medicines have different prices, Sirdalud is cheaper. Sirdalud is a more modern drug; it is produced in a special form, resulting in a long-term release of the active substance. This makes it possible to take the tablets once and reduce the risk of side effects.

Mydocalm is drunk 3 times a day. Sirdalud enters the bloodstream faster and begins to act an hour after administration. Mydocalm can be used to treat children; it has fewer side effects and contraindications. Mydocalm does not cause drowsiness.

More than 20 years ago, a study published in the British Medical Journal was the first to describe good results for the treatment of acute musculoskeletal pain with tizanidine in combination with ibuprofen.

Tizanidine is an alpha-adrenergic agonist, that is, a substance that mimics the effect of the neurotransmitter norepinephrine on type 2 alpha-adrenergic receptors. In this way it is similar to the well-known clonidine (clonidine).

The main function of such receptors is to regulate the release of a neurotransmitter, which transmits excitation from peripheral organs to the brain. Stimulation of alpha-adrenergic receptors leads to a decrease in neurotransmitter output, thus stopping further signal transmission. Since the action of tizanidine interrupts transmission at the spinal level, a strong analgesic effect is observed.

However, alpha2-adrenergic agonists also lead to other consequences in the body, for example, decreased blood pressure, weakness, bradycardia, and drowsiness. In this regard, doctors recommend taking tizanidine at night.

If Mydocalm and Sirdalud are compared by their mechanism of action, there will be a number of differences. The main component of Mydocalm, tolperisone, is a beta-amine ketone according to its chemical characteristics, and a blocker of nicotine-sensitive cholinergic receptors according to its biological characteristics. The effects it exhibits are comparable to the effects of the sodium channel blockers lidocaine and novocaine.

The nerve impulse has an electrochemical basis. To implement it, it is necessary for sodium ions to penetrate into the cell through special channels in the membrane. The signal to open the channels is the binding of the neurotransmitter acetylcholine to the receptors. If, instead of acetylcholine, the “wrong” substance, for example, tolperisone, binds to such a receptor, the channels will not open and a nerve impulse will not follow.

It has been established that tolperisone reduces the permeability of nerve cell membranes to sodium by approximately 50%. In relation to calcium channels, it also acts as an antagonist, that is, it blocks the entry of calcium into the cell. In addition, experiments on isolated cells showed that tolperisone stabilizes cell membranes.

The first pharmacological assessment of the blocking effect of tolperisone on the central nervous system dates back to 1958. Since then, it has proven to be an excellent muscle relaxant in many randomized clinical trials.

For example, out of 250 patients taking Mydocalm for lower back pain, 225 had no pain after a week both at rest and during physical activity. The subjects tolerated the treatment well; only 5% of patients experienced side effects such as dizziness, nausea, and allergies.

Thus, an important advantage of Mydocalm is the lack of sedation when taken.

Indications and contraindications

The detailed annotation for the drug contains a list of symptoms, the manifestation of which is an indication for the use of Sirdalud. What does this medicine help with:

• Pain in the lumbar spine;
• Cervical and spinal syndromes;
• Diseases of the spine accompanied by painful muscle spasms;
• Painful sensations in the postoperative period, as well as those caused by the presence of intervertebral hernias, osteochondrosis, osteoarthrosis and diseases in the area of ​​neuralgia;
• High muscle tone caused by diseases such as multiple sclerosis, chronic myelopathy, cerebral palsy, and also acquired after cerebrovascular accidents.

There are a number of conditions when taking the drug is associated with an increased risk of side effects and is not recommended for use.

Categorical contraindications:

• Children under 18 years of age (clinical studies of the drug in this age group have not been conducted);
• Breast-feeding;
• Severe pathological conditions of the liver;
• Concurrent use of strong inhibitors of cytochrome P450 1A2 (CYP1A2), in particular cycloprofloxacin and fluvoxamine;
• Individual intolerance to galactose, lactase deficiency, impaired absorption of glucose and galactose (among the components of Sirdalud there is lactose).

The drug may be taken under medical supervision:

• Age group from 65 years;
• Pregnancy, including at the planning stage (clinical studies of the drug have not been conducted in this category of patients, the use of the drug is allowed if the treatment result is a priority over possible pathologies in the fetus);
• Kidney failure;
• Minor abnormalities in liver function;
• The presence of allergic reactions to tizanidine or other components of the drug.

Use during pregnancy and lactation

Controlled studies of the use of Sirdalud in pregnant patients have not been conducted, so it should not be prescribed to this category of patients (except in cases where the potential benefits outweigh the possible risks). Experiments on animals did not reveal clear signs of teratogenicity of the drug.

When it was administered to animals in daily doses of 10 and 30 mg/kg, an increase in gestational age was observed. Cases of prenatal and postnatal fetal death, as well as delays in its development, have been recorded. When females took the above doses, they exhibited severe symptoms of sedation and muscle relaxation. Taking into account body surface area, the above doses exceeded the maximum permissible dose for humans (0.72 mg/kg per day) by approximately 2.2 and 6.7 times.

Animal studies show that tizanidine is excreted in small concentrations in the milk of lactating females. It is not recommended to use Sirdalud during lactation, since there is no information on the penetration of this compound into breast milk in humans.

Before starting treatment with Sirdalud, patients of reproductive age should obtain information about the result of a pregnancy test.

When Sirdalud was administered in daily doses of 10 and 30 mg/kg to male and female males and females, respectively, there was no adverse effect on fertility. In males receiving the drug in doses exceeding 30 mg/kg per day, and females in doses exceeding 10 mg/kg per day, a decrease in fertility was observed.

Taking into account the body surface area, the indicated doses exceeded the maximum permissible dose for humans (equal to 0.72 mg/kg per day) by 2.2 and 6.7 times. When pregnant females took such doses, special clinical symptoms were observed, expressed in ataxia, loss of body weight and pronounced signs of sedation.

Reviews

Karina Bolshakova (traumatologist), 43 years old, Murom
These pharmaceutical products have the same pharmacokinetic and therapeutic profiles, therefore they are interchangeable. They are available in tablet form. But in cases where you need to quickly eliminate severe pain, it is better to choose Mydocalm, because it additionally contains the anesthetic lidocaine.

Anatoly Sapozhkov (traumatologist), 32 years old, Arkhangelsk

The drug Sirdalud does not contain lidocaine, which is both its advantage and disadvantage. The advantage is that this substance helps to quickly relieve pain, but the disadvantage is that some patients are allergic to it. At the same time, Sirdalud is more often used for long-term therapy, and Mydocalm for emergency cases.

Vasily Patronov, 56 years old, Karaganda

Mydocalm gave me only short-term relief. Sirdalud lasts longer, but while using it, you constantly feel sleepy. Therefore, to avoid problems, it is necessary to avoid driving during treatment.

Irina Samovolova, 34 years old, Krasnodar

I used both drugs at different times. Mydocalm suited me better, because... it contains lidocaine. The pain goes away instantly. Sirdalud acts more slowly, but lasts longer.

The dosage in such cases is selected depending on the reaction to the drug and the severity of symptoms.

• The initial dosage is 2 mg three times a day.
• After a few days, you can increase the dosage of namg.
• The optimal daily dosage is from 12 to 24 mg.
• Dosages above 36 mg per day are fraught with the development of side effects.

2. Dosage for elderly patients.

The dosage for elderly people is adjusted. Such patients should be under constant supervision of medical personnel. Most often, the dosage is reduced because renal clearance (the rate at which the kidneys excrete various substances from the blood) is slower in older people. A large dosage will cause the accumulation of metabolites in the blood, the development of an overdose, and the appearance of adverse reactions.

For renal failure, the average dosage is 2 mg three times a day. Depending on the further clinical picture and the tolerability of the drug, the dosage and frequency of administration are adjusted.

Compound

• microcrystalline cellulose,
• stearic acid,
• anhydrous lactose,
• colloidal silicon dioxide.

A comparison of the drug Sirdalud with Mydocalm shows that they have slight differences in indications for use.

Sirdalud is advisable to use in the treatment of:

• Convulsive lesions of the limbs;
• Severe muscle spasms.

Mydocalm should be taken by patients who suffer from:

• Pathological hypertonicity;
• Muscle rigidity;
• Pain during active movement.

Mydocalm is contraindicated in the following cases:

• The patient has hypersensitivity to the constituent components;
• Myasthenia;
• Infants under 12 weeks.

Sirdalud is not prescribed for:

• Liver diseases;
• Intolerance to the composition of the drug;
• The patient is taking Fluvoxamine;
• The patient has not reached 18 years of age.

Patients are prohibited from taking Mydocalm and Sirdalud at the same time, since this combination minimizes the therapeutic effect of each of them and provokes the development of side effects. One of these drugs may be part of complex therapy, but taking any of them as self-medication is strictly prohibited.

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Patients suffering from spinal diseases often have a question: how to take Sirdalud tablets for osteochondrosis? This is due to the fact that these tablets are in most cases prescribed for this pathology.

The main task of muscle relaxants taken for osteochondrosis is to relax the skeletal transverse muscles, which is achieved by influencing the central nervous system.

The medicine for osteochondrosis Sirdalud is recommended to be taken for severe pain and muscle-tonic syndromes. After the patient takes the tablets, the active substance is absorbed into the bloodstream through the intestinal walls almost immediately.

For reference. The maximum concentration of the active substance is observed 1.5 hours after taking the tablet.

The dosage of Sirdalud is determined exclusively by the attending physician and depends on the severity of the clinical phenomena of the spinal disease:

• the initial minimum dosage is 2 mg. This amount of the drug should be taken 3 times a day;
• with pronounced muscle spasms, the single dose is increased to 4 mg;
• in order to achieve the maximum therapeutic effect, the patient is prescribed up to 26 mg of Sirdalud per day.

In order to prevent side effects from drug withdrawal, the dosage is gradually reduced at the end of therapy.

You can get an idea of ​​how the drug Sirdalud acts on the body and what negative reactions it causes from patient reviews.

“The muscle relaxant Sirdalud saves me. For many years now I have been suffering from osteochondrosis of the lumbar and thoracic spine. I treat this pathology periodically when the pain is unbearable. This medication is a good pain reliever and relieves muscle spasms. I take tablets in the minimum dosage – 2 mg, and only before bed.

I can’t afford a larger dosage, since Sirdalud causes severe drowsiness and inhibits many reactions. I drive, so side effects from taking pills and transportation are incompatible concepts. Moreover, even such a small dose helps me.

Learn how to cleanse your joints with rice.

Conclusion

Sirdalud is a muscle relaxant that is often prescribed to patients suffering from osteochondrosis. The dosage depends on the severity of the manifestations of the pathology, and is determined only by the attending physician.

People over the age of 65 should use the tablets with extreme caution and monitor their blood pressure and general health.

We have selected real reviews about the drug Sirdalud, which are published by our users. Most often, reviews are written by mothers of young patients, but they also describe their personal history of using the drug on themselves.

- painful muscle spasm associated with static and functional diseases of the spine (cervical and lumbar syndromes), as well as after surgical interventions (for example, for a herniated disc or osteoarthritis of the hip joint);

- spasticity of skeletal muscles in neurological diseases, for example, multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, consequences of cerebrovascular accidents and cerebral palsy (patients over 18 years of age).

If you are deciding which is better to buy: Mydocalm or Sirdalud, you need to study the composition and properties of both products. In this case, the active substance, its concentration, the principle of its effect on the body, and the method of application are compared. Pay attention to contraindications and side effects.

Available in the form of tablets and solution for injection. The main component is the substance tolperisone hydrochloride. Contained in different concentrations, 50 and 150 mg in tablets and 100 mg in ampoules. When prescribing an injection solution, you need to take into account that the composition, among other things, also includes lidocaine. This substance is contraindicated in a number of pathological conditions.

The drug Mydocalm is a muscle relaxant drug. It affects the central nervous system. The active substance tolperisone interferes with the conduction of impulses in neurons. This leads to blocking of spinal reflexes. This principle of action of the drug allows you to reduce muscle tone, thereby improving the ability to perform voluntary movements.

The active substance stabilizes cell membranes, prevents the penetration of sodium and calcium into the membranes of nerve cells. During administration, there is no sedative effect. Soon after the start of therapy, pain in the affected area disappears. The active compound enters the liver and kidneys, where it is metabolized. 99% of the substance is eliminated from the body.

Contraindications for taking Mydocalm:

• intolerance to the components of the drug;
• myasthenia gravis;
• infants under 12 weeks.

Contraindications for taking Sirdalud:

• liver dysfunction;
• hypersensitivity to the components of the drug;
• pregnancy period;
• children under 18 years of age.

Petr Veniaminovich, neurologist

These drugs are prescribed to patients with osteochondrosis and diseased joints to eliminate pain and relieve muscle spasms. The tablets act quickly and are highly effective.

Maria Arkadyevna, neurologist

Many patients complain of muscle spasms, numbness of the limbs, and pain when moving. In such cases, these medications are prescribed.

Mikhail Fedorovich, 63 years old

I have been suffering from spinal osteochondrosis for several years. There are often muscle spasms, soreness, and numbness in the legs. For treatment I take Mydocalm. This is an excellent drug that quickly helps relieve negative symptoms.

Vera Ivanovna, 58 years old

I suffer from arthrosis of the knee joints. There is often severe pain. To eliminate pain, on the recommendation of a doctor, I take Sirdalud. It helps quickly eliminate soreness.

Dmitry, 45 years old

Lately I noticed that my knees began to hurt. Sometimes there is severe pain and difficulty walking. I went to the doctor. An examination was ordered. After the diagnostic measures were carried out, a diagnosis of osteoarthritis of the knee joints was made. Sirdalud was prescribed for treatment. After a course of treatment, the pain went away, and now my condition has improved.

Arkady

After surgery to remove a hernia, Mydocalm was prescribed as a pain reliever. This drug helped quickly eliminate the pain. Now I feel good, the postoperative period went well.

Medicines are inexpensive. Sirdalud is cheaper than Mydocalm. Mydocalm costs 400-600 rubles, Sirdalud – 200-500 rubles.