Ursosan for biliary dyskinesia and after removal of the gallbladder

Cholecystitis refers to inflammatory processes in the gallbladder and bile ducts caused by stagnation of bile. The disease is characterized by acute and chronic course. Doctors call the main cause of acute cholecystitis the presence of calculi (stones) in the gallbladder, which prevent the normal outflow of bile. The chronic form of the disease develops with prolonged irritation of the bladder walls. Factors influencing the development of cholecystitis are infectious diseases, irregular and unbalanced diet, hereditary predisposition, and sedentary lifestyle. In the absence of adequate treatment, chronic cholecystitis often develops into an acute form.

Cholecystitis requires complex therapy, carried out under the supervision of a specialist. Treatment often includes choleretic drugs prescribed to the patient to normalize the outflow of bile and prevent the formation of stones in the gallbladder. Such medications can be prescribed by a doctor only if the patient has no calcified stones in the gall bladder as a result of an ultrasound examination. Liquefing bile if stones are present is very dangerous, as they can block the bile ducts and prevent its outflow.

Adverse reactions of the drug Ursosan

Unfortunately, any drugs, along with benefits for the body, can also have side effects.
Research shows that side effects when taking Ursosan are rare, however, this does not make them impossible. If any of the following reactions occur, it is important to consult a doctor as soon as possible and stop taking the drug until the doctor decides

In particular, you should pay attention to the following possible side effects:

• nausea turning into vomiting;
• diarrhea or, conversely, constipation;
• lower back pain;
• emerging alopecia areata (hair loss);
• as well as allergic skin and swelling reactions.

The lowest rate is the side calcification of stones, which is also likely to be one of the side effects of taking the medication.

Side effect

During long-term use of Ursosan, regular biochemical tests are performed to monitor the level of liver transferases. These are enzyme catalysts for chemical reactions of nitrogen metabolism, the main task of which is the transport of amino groups for the formation of new amino acids. An increase in their concentration can negatively affect the patient’s well-being, so gastroenterologists adjust the dosage or temporarily discontinue the pharmacological drug.

Almost all side effects of Ursosan are related to the functioning of the gastrointestinal tract and manifest themselves in signs of indigestion. These include:

• increased gas formation;
• disturbance of intestinal motility;
• attacks of vomiting, nausea;
• painful cramps in the abdominal area.

A course of treatment with Ursosan sometimes leads to calcification of gallstones. If any of the above negative signs occur, you should immediately contact a gastroenterologist. He will conduct an examination and, in the absence of any pathological process, will reduce the single and (or) daily dosage.

Side effects of Ursosan often occur in patients who neglect medical recommendations. Also, disruption of the gastrointestinal tract or exacerbation of chronic diseases is diagnosed in adherents of self-medication who take pharmacological drugs on the advice of neighbors or pharmacists in pharmacies.

How to take Ursosan

Ursosan capsules are taken with a comfortable amount of non-mineral water. The best time to take the drug for one-time use is in the evening. Capsules are drunk during dinner or immediately after it, however, taking the drug Ursosan with food, you can achieve better results. If it is recommended to take Ursosan according to a 2- or 3-daily treatment regimen, the intake should occur in the morning and evening (with breakfast and dinner) or in the morning, lunch and evening (with breakfast, lunch and dinner).

The duration of treatment and individual dosage are prescribed depending on the established diagnosis and the personal characteristics of the patient. As a rule, the standard dose is calculated based on the recommendation of 10 mg for each kg of the patient’s body weight. For example, a person weighing 65 kg for therapeutic purposes should receive 650 mg (65*10=650).

Dosage for dissolving stones

In the case of the intended purpose for dissolving formed cholesterol stones, the drug Ursosan is recommended to be consumed in quantities from 2 to 5 capsules, once a day. Treatment is carried out daily, for the period of time that was established and continued by the doctor until the stone formed is completely dissolved. In addition to the treatment period, 2 or 3 months of prophylactic use of Ursosan are added to prevent new formations, so the course of treatment can last from two to three months to twelve.

The main condition under which it is necessary to take Ursosan is the visibility of stones on X-ray examination and their diameter not exceeding 20 mm in diameter. It is not recommended to use Ursosan capsules for resorption of stones in case of impaired functioning of the gallbladder (i.e., dyskinesia due to cholelithiasis will no longer be an indication, but a contraindication for use), as well as insufficient patency and blockage of the biliary tract. At the same time, it is necessary to take into account that the total number of stones in gallstone disease should not clog the gallbladder by more than half.

The daily dose of medication is taken once a day, in the evening during dinner or, without delay, after it.

To prevent stone formation

Taking Ursosan to prevent the formation of stones is necessary only with a doctor's prescription. It is likely that your doctor will determine that you need to take one capsule twice a day. The period of prophylaxis is 3 or 4 months.

Dosage for hepatitis, fibrosis, dyskinesia

Hepatitis, fibrosis or dyskinesia of the biliary tract, as well as the gallbladder, require a slightly increased dosage of 15 mg per kg of the patient’s weight. So, a person weighing 65 kg will need 975 mg (65*15=975) of the drug, which is equivalent to 4 capsules. It is quite difficult to take such a dosage at one time, so it is usually divided into 2 doses of Ursosan per day. It is still recommended to take the capsules with meals. The course of treatment is also quite long and can take several months to a year or even a couple of years.

For toxic liver damage

The resulting toxic (if a toxic drug or alcohol is used for a long time) liver damage is treated with 10 or 15 mg of Ursosan per kg of weight. Accordingly, a person weighing 80 kg will need from 800 to 1200 mg of the drug per day, which is equivalent to 3 or 5 capsules taken twice a day. The course of treatment for such conditions lasts for six months with a possible extension of up to a year.

For primary biliary cirrhosis

Treatment for primary biliary cirrhosis can also be carried out using Ursosan. The dose, as in other cases, is calculated according to the prescription: 15 or 20 mg per kg of weight. So, a person weighing 70 kg per day needs to take from 1050 to 1400 mg of medication, which consists of 4 or 6 capsules. The daily amount of the drug must be divided into 2 or 3 doses, combining the capsules with food, traditionally consumed for dinner. The course will range from 6 to 24 months.

Chronic cholangitis

Therapy for chronic cholangitis is carried out with the intake of 12 or 15 mg per kg of body weight, divided into two or three doses of Ursosan per day. The use of the drug for chronic cholangitis is also considered long-term and takes from six months to a couple of years.

Drug treatment of gastritis

Treatment of hyperacid gastritis is a complex process that includes several important stages. In modern pharmacology, there are a large number of medications that can not only speed up the treatment process, but also alleviate the painful manifestations of the disease. Only a specialist can draw up an individual treatment plan, because gastritis is not a disease that can be cured on its own or with the help of traditional medicine. The attending physician selects certain medications, taking into account the data obtained after diagnosing the patient.

To treat gastritis, the following groups of medications can be used:

1. Aimed at treating an acute form of the disease, relieving pain and other uncomfortable symptoms. It is appropriate to take “No-Shpa”, “Papaverine” and “Ampicillin”;
2. Those struggling with the chronic form. The use of antiemetic medications and prokinets is suitable: Sulpiride, Domperidone. Enzymatic preparations are also suitable: “Smecta”, “Mezim”;
3. Aimed at eliminating reflux gastritis. You can use Ursosan, Motillium;
4. Preparations with homeopathic effect. Iberogast and Ecolulko are considered the most effective for treating gastritis with low acidity;
5. Aimed at combating inflammatory processes. Patients are often prescribed a course of taking De-Nol, Gastal, Almagel, Metronidazole, Ranitidine.

Only a therapist or gastroenterologist can describe a detailed diagram of how to treat gastritis. Independent use of even the most expensive and high-quality products can have disastrous consequences.

Ursosan for dissolving gallstones

People who have gallstones are looking for answers to their questions: is it possible to avoid surgery to remove the gall bladder and dissolve the stones, including with Ursosan.

I myself was once looking for such information, I went for a consultation at the Research Institute of Gastroenterology in Moscow. And I strongly advise everyone not to read forums, reviews of people who have used this or that medicine, but be sure to discuss everything with your doctor. Only he will tell you whether you can take these drugs.

And another important detail is that you can only take these drugs to dissolve gallstones under the supervision of a doctor. You also need to undergo examinations during treatment, additional blood tests, ultrasounds, etc. What do we need to know at our everyday level if we are looking for such information?

In order for this medicine to be effective, the following conditions are necessary:

• the size of cholesterol stones is no more than 1.5-2 centimeters;
• stones occupy no more than half the volume of the gallbladder;
• there are no stones in the bile ducts, and the gallbladder has retained its function;
• there are no signs of acute inflammation of the gallbladder (acute cholecystitis), severe liver diseases in the decompensation stage;
• body weight is within “decent” values ​​(no severe obesity).

This method of dissolving gallstones takes quite a long time, therefore, in order for the dissolution attempt to be successful, this medicine will have to be taken for a long period of time: from 6 months to 2 years.

Ursosan - contraindications

According to the instructions for use, UDCA has relative and absolute restrictions on its use. The first category of contraindications for Ursosan includes children aged 2 to 4 years, which is explained by the child’s inability to sufficiently swallow large capsules. However, children can take the medicine if parents open the gelatin shell and mix the powder with water. Absolute contraindications for Ursosan are:

• X-ray positive structure of gall bladder stones;
• acute cholecystitis;
• gallbladder dysfunction;
• acute cholangitis;
• replacement of parenchymal tissue with fibrous tissue in the stage of decompensation;
• renal failure;
• obstruction of the biliary tract;
• liver failure;
• allergies.

Dosage regimen

Take orally, during or after meals, without chewing, with a sufficient amount of water.

To ensure the recommended dose, the tablet should be divided in half, breaking at the score. Segments broken incorrectly should not be used. When holding the segment in the mouth, a bitter taste is felt.

To dissolve cholesterol gallstones

the average daily dose of the drug is 10 mg/kg (up to 12-15 mg/kg). The daily dose of the drug is taken once at night. The course of treatment is 6-12 months or more until the stones are completely dissolved. If gallstones do not decrease in size after 12 months of treatment, the drug should be discontinued.

To prevent re-formation of stones

It is recommended to use the drug for several months after the stones have dissolved.

To prevent recurrent cholelithiasis after cholecystectomy

prescribed 250 mg (1 capsule or 1/2 tablet) 2 times a day for several months.

For chronic hepatitis of various origins (including toxic, medicinal), chronic viral hepatitis, non-alcoholic fatty liver disease, incl. non-alcoholic steatohepatitis, alcoholic liver disease

the average daily dose is 10-15 mg/kg in 2-3 doses. The duration of therapy is 6-12 months or more.

For cholestatic liver diseases of various origins, incl. primary biliary cirrhosis (in the absence of signs of decompensation), primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis)

the average daily dose is 12-15 mg/kg, if necessary – 20-30 mg/kg. During the first 3 months of treatment, the daily dose of the drug should be divided into 2-3 doses. If biochemical blood parameters improve, the daily dose of the drug is taken once at night. The duration of therapy ranges from 6 months to several years.

For biliary dyskinesia

the average daily dose is 10 mg/kg in 2 divided doses for 2 weeks to 2 months. If necessary, it is recommended to repeat the course of treatment.

For biliary reflux gastritis and reflux esophagitis

the average daily dose is 250 mg (1 capsule or 1/2 tablet) 1 time at night. The course of treatment is from 2 weeks to 6 months, if necessary – up to 2 years.

Calculation of the daily amount of capsules and tablets depending on the patient’s body weight and the recommended dose of the drug per 1 kg of body weight, mg/kg/day

Getting rid of illness with proper nutrition

The fight against gastritis does not end with the use of medications; you will also have to adhere to proper nutrition. As a rule, nutritionists prescribe the No. 1 healing diet for high pH levels, but more accurate information can be obtained after a personal consultation. For a long time you will need to give up sour fruits and vegetables, canned food and juices.

What is prohibited to eat with gastritis

1. Pearl barley, millet, corn grits, beans, peas. Only buckwheat, oat and rice cereals are allowed;
2. Fatty pork, goose, duck, fried meat and canned meat;
3. Halibut, sardines, eel and catfish, smoked and seasoned products;
4. Cucumbers, cabbage, radishes, ripe tomatoes and any vegetables in marinade, canned food and pickled products;
5. Any sour and dried fruits;
6. Fresh bread, rich and flaky store-bought pastries;
7. Smoked and spicy sausages. Rare consumption of boiled sausage is possible;
8. Chocolate and all kinds of products with it, ice cream;
9. High-fat dairy products, store-bought cheeses with spices and seasonings, glazed cheese curds, store-bought sweet yoghurts and curds, vegetable oils and animal fats;
10. Alcohol products, soda, citrus juices, strong teas, coffee without milk and kvass.

Healthy and recommended dishes

1. Pasta dishes in small quantities (any type of product is suitable);
2. Rabbit, beef, veal meat, turkey, chicken;
3. Low-fat fish, boiled or steamed;
4. All vegetables except those listed in the list of prohibited foods. Only boiled, fresh and baked foods are suitable;
5. Eating sweet fruits and berries, which make excellent compotes, juices, jelly, and purees;
6. Stale bakery products;
7. Strawberry, wild strawberry and pumpkin jams, butter cream, marshmallows, marshmallows, honey. However, if possible, it is better to avoid any sweets and confectionery products, especially during periods of exacerbation;
8. Low-fat dairy and fermented milk products. Preference should be given to low-fat sour cream, cottage cheese, cream, periodic consumption of kefir, yogurt and cheeses, unsalted butter and ghee;
9. Scrambled eggs. Rare (up to 2 times a day) consumption of steamed omelettes is acceptable. Fried or hard-boiled eggs are strictly prohibited;
10. Herbal decoctions and weak natural green, black, flower teas. It is allowed to drink coffee diluted with milk, freshly squeezed juices, fruit and berry compotes. You should not drink drinks on an empty stomach.

As for sauces, spices and seasonings, you can use fresh parsley, dill, cinnamon and vanilla. All other seasonings, in particular hot or overly spicy ones, should be eliminated completely. The use of ketchups, any mayonnaise, vinegar and other sauces based on them is also prohibited. It is advisable to steam all food using less fat and all kinds of flavor enhancers. The use of vegetable oil is appropriate only as a salad dressing, but in no case for frying dishes.

Treatment of the disease is a set of procedures that can provide the patient with a favorable prognosis. A patient who has suffered from the disease must permanently give up bad habits and irregular diets so as not to develop complications: gastritis can easily turn into an ulcer. Other preventive measures are also important: maintaining strict personal hygiene, regular examinations and exercise.

Ursosan medicine use

We will describe reviews of this drug at the very end of the article. Now we will tell you how it should be taken.

The drug capsules must be swallowed whole with plain water.

How to take Ursosan for certain deviations? The instructions for its use contain the following information in this regard:

• For cholelithiasis and diffuse liver pathologies, the medicine is prescribed for a long time (continuously) in a daily dosage of 2-5 capsules (depending on body weight). For diffuse deviations, the daily volume of the drug should be divided into 3 doses. When to take Ursosan capsules: before meals or after? The medicine must be used while consuming food.
• For cholelithiasis, the daily dosage is taken once before bedtime. The duration of therapy (to dissolve stones) is 3 months, and then several more weeks to prevent relapses.
• For deviations such as reflux esophagitis and biliary reflux gastritis, the medication is prescribed one capsule at night. The course of treatment can be either 15 days or 7 months (if necessary, 2 years).
• After cholecystectomy, the recommended dosage is 250 mg twice daily for several months.
• For drug-induced and toxic liver damage, as well as biliary atresia and alcoholic illness, the drug is prescribed at the rate of 10-15 mg per 1 kg of body weight, taken in 3 divided doses. Duration of therapy is 6-12 months or longer.
• For biliary cirrhosis (primary), the medication is taken at the rate of 10-15 mg per 1 kg of patient weight per day (but not more than 20 mg per kg) in 3 divided doses. The duration of treatment ranges from 6 months to several years.
• For sclerosing cholangitis (primary), the drug is taken in a dosage of 12-15 mg per 1 kg of body weight per day (up to 20 mg per kg) in 3 divided doses. The duration of treatment is from 6 months to several years.
• For non-alcoholic steatohepatitis - 13-15 mg per 1 kg of body weight per day (in 3 divided doses). The duration of therapy is from 6 months to several years.
• For cystic fibrosis, the dosage is prescribed at the rate of 20-30 mg per 1 kg of weight (3 doses per day). The duration of treatment is from 6 months to several years.
• For children over 2 years old, the amount of medication consumed is determined individually (but not more than 10-20 mg per 1 kg of body weight per day).

Ursosan for newborns - instructions for use

A newborn baby may develop jaundice, which is a physiological condition. Physiological is considered jaundice, which lasts no longer than three weeks. If after three weeks the jaundice does not decrease, then we are talking about a pathological condition. If the jaundice gradually decreases, but has not completely disappeared by the first month after birth, then this is a variant of the norm. Gradual normalization of skin color is allowed up to 4 months. In these situations, neonatologists recommend not taking any medications.

Jaundice in newborns is caused by the breakdown of a large amount of hemoglobin, which the liver is not able to quickly remove. However, with very severe jaundice, when the bilirubin level is high, damage to the central nervous system is possible. In such situations, it is necessary to reduce the concentration of bilirubin with medication. To eliminate such severe and dangerous jaundice, doctors recommend giving the child Ursosan. The drug is taken for 2–4 weeks in a row, a quarter of a capsule daily.

Doctors recommend pouring the contents of the capsule onto a saucer, dividing it into 4 equal parts and giving it to the child, dissolving it in water or breast milk. With good, positive dynamics (that is, if the jaundice goes away quickly), you can reduce the course of treatment to 10 days. Every week while taking Ursosan, the concentration of bilirubin in the blood should be monitored. On average, weekly use of Ursosan provides a decrease in bilirubin concentration of 50 units. Once the bilirubin concentration in the blood reaches 100 mg/ml, the drug can be discontinued.

Ursosan can be used to treat various diseases of the liver and biliary tract in children starting from 2 years of age. In this case, the dosage is calculated for each child individually, depending on body weight, based on the ratio of 10 - 20 mg per 1 kg of weight. In this case, the child should be given the entire daily dosage in the evening, during meals. If the child cannot swallow a large enough capsule whole, the contents should be poured into water and dissolved. Then give the child Ursosan in the form of a solution to drink. In this case, you should make sure that the child drinks the entire solution.

Children aged 2 to 4 years may have difficulty swallowing capsules, so it is necessary to monitor the time of taking the drug. As a rule, children tolerate this drug well. Ursosan helps in the treatment of acute hepatitis in childhood, as well as with various disorders of the outflow of bile (for example, with atresia of the bile ducts). Ursosan will also help cope with various digestive disorders in children that arise from the abuse of fatty or fried foods.

Directions for use and doses

Inside,

with a small amount of water.

To dissolve cholesterol gallstones

the average daily dose of the drug is 10–15 mg/kg. The course of treatment is 6–12 months or more until the stones are completely dissolved. For cholelithiasis, the entire daily dose of the drug is taken once at night.

To prevent re-formation of stones, it is recommended to use the drug for several months after the stones have dissolved.

After cholecystectomy

for the prevention of recurrent cholelithiasis - 250 mg 2 times a day for several months.

For chronic hepatitis of various origins (toxic, medicinal), chronic viral hepatitis, non-alcoholic fatty liver disease, incl. non-alcoholic steatohepatitis, alcoholic liver disease,

the average daily dose is 10–15 mg/kg in 2–3 doses. Duration of therapy is 6–12 months or more.

For cholestatic liver diseases of various origins, incl. primary biliary cirrhosis, primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis),

average daily dose - 12–15 mg/kg; if necessary, the average daily dose can be increased to 20–30 mg/kg in 2–3 doses. The duration of therapy is from 6 months to several years.

For biliary dyskinesia of the hypokinetic type

the average daily dose is 10 mg/kg in 2 divided doses for 2 weeks to 2 months. If necessary, it is recommended to repeat the course of treatment.

For biliary reflux gastritis and reflux esophagitis

- 250 mg/day before bedtime. The course of treatment is from 10–14 days to 6 months, if necessary – up to 2 years.

Calculation of the daily number of capsules depending on the patient’s body weight and the recommended dose of the drug per 1 kg of body weight

Effect of drugs

Depending on whether the acidic environment is low or high, the motility of the intestines and stomach is impaired and how much the mucous membrane is affected, the doctor prescribes the type of drugs and dosage.

You cannot treat gastroduodenitis on your own, using only one type of medication. A complex effect must be applied to the body, otherwise the inflammatory process will not be cured and complications will arise.

If the causative agent of the disease is the Helicobacter bacterium, 2-3 types of antibiotics are prescribed. This could be Metronidazole, Amoxicillin, Alpha Normix, etc. These are broad-spectrum drugs that effectively destroy many types of bacteria, including Helicobacter pylori.

In addition, medications in this group reduce the risk of re-infection with these bacteria. In the case when Helicobacter is not detected in the body, and the causative agents of the infection are Giardia or other parasites, Alpha Normix and other antibiotics are not used.

Antacids are successfully used in the treatment of gastroduodenitis with high acidity. They lower the level of acidic environment inside the stomach, bringing it back to normal. They also help restore the mucous layer.

Effective drugs in this group are Omez, Omeprazole, Nolpaza. Also, Maalox, Phosphalugel, Almagel, etc. are often used. Antacids are taken orally an hour after meals. By this time, the digestive process in the stomach is completed. In the treatment of superficial gastroduodenitis with suspended secretory function, Phosphalugel, Nolpazu, Omez are prescribed twice a day.

If a patient has this gastrointestinal disorder, characterized by low acidity, he is prescribed enzyme preparations (Prozerin, calcium gluconate, Betacid, Etimizol, etc.). They stimulate acid production and increase this indicator to normal levels.

Since gastroduodenitis is characterized by damage to the mucous layer of the digestive organs, it is necessary to restore its activity. For this, products such as De-nol, Sucrafot, etc. are used. They protect the upper layer of the mucosa from damage and acid corrosion.

An effective drug used in the treatment of erosive gastroduodenitis is De-nol. It perfectly heals damaged mucous membranes. In addition, De-nol inhibits the activity of Helicobacter, so it is often used in combination with antibiotics.

Use of the drug Ursosan

To dissolve gallstones, as well as in the treatment of acute and chronic liver diseases, Ursosan is used at a dose of 10 mg/kg per day without interruption for a long time.

The duration of taking Ursosan to dissolve cholesterol gallstones ranges from 6 months to 2 years. If after 12 months from the start of taking Ursosan there is no reduction in gallstones, it is not advisable to continue treatment. When treating biliary reflux gastritis, the drug is prescribed 250 mg once a day before bedtime. The duration of treatment is usually 10–14 days. When treating cholestatic syndrome for different types of liver damage, the daily dose depends on the patient’s body weight. Usually this is 8–12 mg of ursodeoxycholic acid per 1 kg/day, that is, 500–700 mg (2–4 capsules).

The maximum daily dose is 1500 mg (6 capsules). The duration of treatment for chronic liver diseases can range from several months to 2 years. For children over 3 years of age, dosage is individual - it is recommended to prescribe 10–20 mg/kg/day. The capsules are swallowed without chewing, washed down with a sufficient amount of water.

Instructions for use

The patient should swallow the capsules whole with a small amount of water (50 ml). For best effectiveness of the medicine, it is recommended to take the daily dose once in the evening. According to the instructions for use, it is important to ensure regular use of the drug.

If in childhood (2-5 years), as well as in adults with body weight up to 47 kg, it is not possible to swallow the capsule, then the use of other dosage forms containing Ursodeoxycholic acid should be considered.

Release form and composition

Available in the form of capsules (250 mg) and tablets (500 mg) in packs of 10, 50 or 100 pieces.

Form, composition and mechanism of operation

The drug "Ursosan" is sold in only one form - white capsules with an opaque gelatin shell. The main component of the drug is ursodeoxycholic acid, which helps normalize the functioning of the gallbladder and neutralize monocarboxylic hydroxy acids, an excessive amount of which has a damaging effect on the gastric mucosa. The modern medication quite quickly relieves the symptoms of biliary reflux gastritis, and also improves the condition of the intestinal microflora due to the lactulose present in the composition. Thanks to this prebiotic, Ursosan helps to overcome dysbiosis, which often accompanies this form of inflammatory stomach disease.

Very important! Savina G.: “I can recommend only one remedy for the quick treatment of ulcers and gastritis” read more.

Indications for use

Most often, you need to resort to the help of Ursosan when it is necessary to remove gallstones from the body without resorting to surgery. The instructions say that this medicine can also be used to prevent the re-formation of stones after cholecystectomy. This medication is often prescribed to patients as part of the accompanying therapy for cancer. In addition to this, there are a number of other conditions for which Ursosan can be prescribed:

• Reflux gastritis and reflux esophagitis,
• Atresia,
• Cholangitis,
• Biliary dyskinesia,
• Primary biliary cirrhosis,
• Alcoholic liver damage,
• Opisthorchiasis,
• Pancreatitis,
• Cholecystitis,
• Hepatitis of various natures.

Symptoms of gastritis with high pH levels

The signs of gastritis with high acidity are similar to the symptoms of other forms of the disease and peptic ulcer disease. Pain in the abdomen, a feeling of heaviness and unpleasant belching after eating are considered an alarming signal and a clear sign of the disease. Hyperacid gastritis also has symptoms characteristic exclusively of this form:

• persistent heartburn;
• periodic constipation or diarrhea;
• the occurrence of pain syndromes at night and “hungry” (period without food) time;
• coloration of the tongue red with a white coating in the middle;
• constant bloating and colic;
• discomfort and pain in the stomach after eating food;
• sharply increased or decreased appetite;
• rare gag reflexes.

The peculiarity of the disease is that acute symptoms sometimes lie dormant for a long time, without manifesting themselves or causing alarm. In such cases, regular examinations by a gastroenterologist are important.

Pharmacokinetics

UDCA is absorbed in the small intestine by passive diffusion (about 90%), and in the ileum by active transport. Cmax is achieved after 1–3 hours and is 3.8 when taken orally 50 mg after 30, 60 and 90 minutes; 5.5 and 3.7 mmol/l, respectively. Tmax is achieved within 1–3 hours. Plasma protein binding is up to 96–99%. Penetrates through the placental barrier. When taking the drug systematically, UDCA becomes the main bile acid in the blood serum. Metabolized in the liver (clearance during primary passage through the liver) into taurine and glycine conjugates. The resulting conjugates are secreted into bile. About 50–70% of the total dose of the drug is excreted in the bile. A small amount of unabsorbed UDCA enters the colon, where it is broken down by bacteria (7-dehydroxylation); the resulting lithocholic acid is partially absorbed from the colon, sulfated in the liver and quickly excreted in the form of sulfolithocholylglycine or sulfolitocholyltaurine conjugate.

Features of the drug

Ursosan - capsules filled with white powder, loose or compressed. The composition includes the following components:

• Ursodeoxycholic acid is the active substance that determines the action of the capsules;
• Corn starch, plain and gelatinized;
• Magnesium stearate;
• Silica.

The capsule shell is made from a compound of gelatin and titanium dioxide. The active substance is mixed with auxiliary elements that improve the absorption of the drug in the gastrointestinal tract and make this process smooth.

The imported drug is available in different dosages (250, 500 and 750 mg), such forms help patients choose the best option for complying with the doctor’s prescriptions. For some pathologies or large weight of the patient, a single therapeutic dose can be 750 mg, so the availability of release forms with different volumes of the active substance is very convenient.

pharmachologic effect

The therapeutic effect of Ursosan is based on the ability of ursodeoxycholic acid to restore damaged liver cells (hepatocytes). This compound is present in small quantities in the human body and is part of bile. Ursodeoxycholic acid has the ability to reduce the production of cholesterol, prevent the thickening of bile, and stimulate immune processes.

Hepatoprotective effect

Due to its polar properties, ursodeoxycholic acid absorbs toxic bile acids, forming large high-molecular conglomerates with them. This ability is used in the treatment of patients diagnosed with:

• reflux esophagitis;
• biliary gastritis with high acidity.

By neutralizing toxic bile acids, Ursosan prevents damage to the mucous membranes and deeper layers of the digestive tract. Ursodeoxycholic acid in the form of double molecules is introduced into membranes:

• liver cells;
• epithelial cells of the mucous membranes of the stomach and intestines;
• gallbladder cells.

This increases the strength of the structural units of the most important digestive organs, making them immune to the action of toxic compounds, regardless of their origin (exotoxins and endotoxins).

By reducing the amount of bile acids that destroy liver cells, Ursosan at the same time stimulates the production of useful biologically active substances. Thus, ursodeoxycholic acid restores the lost balance of bile acids, while simultaneously regenerating hepatocytes.

Despite its single-component composition, Ursosan has a number of contraindications

Reducing cholesterol levels

The active ingredient Ursosan has the unique ability to reduce the concentration of cholesterol produced by hepatocytes. Ursodeoxycholic acid:

• promotes the absorption of excess amounts of this organic compound by the walls of the gastrointestinal tract;
• limits its penetration into the gallbladder.

Moreover, taking Ursosan leads to a significant increase in cholesterol in the bile with the formation of liquid crystalline, easily soluble suspensions.

This property of the pharmacological drug is used by gastroenterologists in the treatment of patients in whom, during instrumental studies, soft stones were discovered in the gallbladder, preventing the normal outflow of bile and causing painful colic. Ursosan is indicated for use as a prophylactic agent for people who are predisposed to the formation of gallstones.

Increasing local immunity

Long-term use of ursodeoxycholic acid inhibits the process by which information encoded in genes is converted into structures present or active in the cell. The direct participants in the body's immune response to the penetration of foreign substances from the outside or those that are products of the breakdown of cells and tissues are gradually activated.

Features of the disease

Gastroduodenitis is a disorder of the gastrointestinal tract, in which the inflammatory process affects the duodenum and the adjacent part of the stomach.

As the disease progresses, the mucous membrane of the digestive organs becomes thinner and degenerates. Defective formations – erosions and ulcers – may appear on it. Atrophy of the mucous layer may occur. In this case, the consequences of the disease will be very severe and difficult to cure.

Gastroduodenitis can be acute or chronic. Acute disorder is manifested by severe intense pain. In the chronic form of the disease, the pain becomes dull and the course is characterized by periods of remissions and exacerbations. The chronic course of the disease can be quite long, up to 10 years. Based on the type of lesion, a focal (localized) and diffuse type of disease is distinguished, which spreads to the entire digestive organ.

Since the inflammatory process is often accompanied by disruption of the secretory gland of the stomach, gastroduodenitis can occur with a deviation in the acidic environment. It happens:

• with high acidity;
• with a low acidic environment;
• with normal secretion.

Depending on this indicator, different treatments are prescribed.

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Often, with this disease, the motility of the intestines and stomach is impaired, and dysfunction of the sphincter (the circular muscle that pushes food into the intestines) may occur. And also, in the inflammatory process, the bile ducts are involved, which is why there are disruptions in the functioning of the gallbladder.

The symptoms accompanying this disease are quite unpleasant. These include frequent pain in the abdominal area of ​​varying intensity, nausea, vomiting, heartburn, as well as constipation, bloating and diarrhea. The general condition of the patient is weakened, he experiences dizziness, headaches, fever, etc.

In order to fully restore the functioning of the body and finally cure the disease, comprehensive treatment is necessary. For complete recovery you need:

• eliminate the causes of inflammation;
• restore the functioning of the digestive organs;
• heal the mucous membrane;
• increase the body's protective functions.

For this purpose, multi-stage treatment with different types of drugs is used.

Ursosan for gallstones

The benefit of the drug in the fight against gallstone diseases is explained by the fact that the components of the drug stimulate the synthesis of secretions and their removal from the digestive system. These processes improve the quality of bile and allow you to quickly cope with congestion in the body. Here are reviews from patients taking Ursosan for gallstones. There are both positive and negative reviews.

Oleg, 53 years old

At the appointment, the doctor discovered 3 small gallstones in me. This problem did not bother me, but the gastroenterologist said that they could increase in size and block the bile ducts. To prevent complications, the specialist prescribed Urososan at a dosage of 250 mg 3 times a day. I can’t say that the drug helped me, because before that I didn’t experience any health problems. But now I will constantly take it to avoid consequences in the future. I recommend that everyone follow a simple diet during treatment: give up fatty and smoked foods. Otherwise, even the most effective drug will be useless.

Rimma, 38 years old

Ursosan is the worst drug I have taken in recent years. The doctor prescribed it to me because of thickening of bile. He said that if timely measures are not taken, gallstones may form. The drug was prescribed to me for 4 months, but after a month of taking it I felt terrible nausea and problems with bowel movements. In addition to side effects, Urososan has another significant drawback - high cost. People who will be forced to take it in courses will have to splurge on the medicine. Instead of Urososan, I take natural medications with a choleretic effect.

Reviews from doctors about the drug Ursosan and side effects

Hepatologists, surgeons and gastroenterologists speak positively about the drug Ursosan. They include this drug in the treatment regimen for pathologies affecting not only the liver, but also other organs of the gastrointestinal tract. Regular use of Ursosan eliminates pathological symptoms: heaviness in the abdomen; tingling in the right hypochondrium; flatulence; bitterness in the mouth, especially pronounced in the morning. Here are doctors' reviews about the drug Ursosan.

Kornilov T. A. – surgeon

I prescribe the drug to patients with fatty hepatosis and gallbladder polyp. With the help of Urososan it is possible to remove small stones from the bile ducts. But in this case, the patient will need to undergo an ultrasound to make sure that there are no stones in the body that exceed the size of the bile ducts. I do not recommend treating gallstones on your own, because this can lead to dangerous consequences and aggravation of the symptoms of chronic diseases. I do not use the drug to prevent stone formation, as it has shown its low effectiveness in practice.

Gvozdeva M. Yu – gastroenterologist

I prescribe Ursosan to patients for the treatment of duodenogastric reflux and elimination of congestion in the biliary tract. Other areas of application of the drug are reducing cholesterol levels in the blood, dissolving sand and small stones in gallstone disease, preventing the re-formation of stones after abdominal surgery and laparoscopy.

Side negative effects

The disadvantages of Ursosan include the fact that patients with its use often experience allergic reactions: dermatosis, urticaria. To achieve a noticeable result, a long-term (course) use of a hepatoprotector is necessary.

Ursosan for polyps in the gallbladder

So far, no effective medications have been developed that can eliminate gallbladder polyps. The shape of the neoplasms resembles thin papillae on a stalk. They belong to the group of benign growths that do not threaten human life. However, polyps can grow in size and make it difficult to digest food.

Polyps can only be treated surgically. The main goal of drug treatment is to eliminate the unpleasant symptoms of indigestion and prevent the occurrence of new growths. Ursosan is an effective remedy that normalizes digestion against the background of the problem.

Polyps make it difficult for bile to flow out of the bladder. Ursosan dilutes bile and prevents its stagnation in the body. For gall bladder polyps, a drug with hepatoprotective properties is taken three times a day. Here are reviews from patients taking Ursosan for polyps in the gallbladder.

Victoria, 47 years old

I discovered a polyp in the gallbladder by accident. Before this, I suffered from heaviness in my right side and bloating after eating. For a long time I suffered from skin allergies, which I treated unsuccessfully at the dermatologist. On an ultrasound, the gastroenterologist discovered 2 large polyps in my gallbladder (0.2 and 0.4 cm in size). The organ was 1/3 filled with stones and sand.

The doctor prescribed me a drug with urodeoxycholic acid - Ursosan at a dosage of 500 mg in the morning and 1000 mg at night. In addition to it, the gastroenterologist advised drinking Odeston. The treatment lasted 3 months. At my second appointment, the doctor noticed positive changes in me - the sand and stones were almost completely removed from the gallbladder, the polyps did not increase in size.

After completing the course, I began to feel much better, and my digestive problems partially disappeared. I think that if I regularly take Urososan courses, I will be able to avoid surgical intervention.

Tatyana, 52 years old

Gallbladder polyps are a common disease that affects most people over 40 years of age. I don't think drugs can help people solve this problem. Many people live with polyps for 10, 20 or more years without taking any medications. Modern medicine offers minimally invasive methods of intervention (through a puncture in the abdominal cavity), after which the patient can quickly recover and return to their normal lifestyle.

How to treat

Based on the examination of the patient, the doctor prescribes appropriate treatment. The type of therapy depends on the severity of the disease, its stage and causes. A fairly common cause of inflammation in the human body is the bacterium Helicobacter pylori. If tests confirm its presence in the mucosa, gastroduodenitis is treated with antibiotics.

If this disorder is caused by the presence of parasites in the duodenum, antibacterial agents are prescribed. To restore normal functioning of the body, the doctor prescribes several types of medications. These include:

• drugs of the antacid group (Omez, Omeprazole, Phosphalugel, Nolpaza, Maalox, etc.);
• antibiotics (Metronidazole, Amoxicillin, Clarithromycin, Alpha Normix, etc.);
• enzymes and substances that stimulate secretory function;
• antispasmodics and painkillers (No-shpa, Drotaverine, Duspatalin, etc.);
• drugs that restore the mucous membrane (De-nol, Sucralfate);
• medications that neutralize the effect of bile acid on the digestive tract (Ursosan, etc.);
• restoratives and vitamin complexes.

Use for prevention

The drug Ursosan can also help in preventing various diseases of the liver and gall bladder. Thus, this drug can be prescribed to patients who have undergone cholecystectomy to prevent the recurrence of stones. As indicated in the instructions, after surgery, capsules should be taken 2 pieces per day for a course of 4 months. In the future, the doctor may decide to extend the course for the purpose of prevention.

Due to the pharmacokinetics of Ursosan, a number of nuances should be taken into account when taking it. The instructions for the drug indicate that it is used during or after meals. The fact is that at this time the gastric juice has the lowest level of activity, due to which nothing prevents the medicine from quickly penetrating the small intestine and being absorbed into the blood.

Interaction with other drugs

Simultaneous use with aluminum-containing antacid drugs (for example, Almagel, Gastal, etc.) or Cholestyramine reduces the effectiveness of Ursosan. The simultaneous use of Ursosan with the following drugs reduces its activity in dissolving gallstones:

• Clofibrate; estrogens (for example, Estradiol, Estriol, etc.);
• Neomycin;
• progestins (for example, Desogestrel, Dydrogesterone, Levonorgestrel, Linestrenol, Megestrol, Medroxyprogesterone, etc.).

Release form and composition of the drug

In pharmacies, this medicine can be purchased in packages that may contain different numbers of capsules: 10, 50 or 100. Sometimes buyers call Ursosan tablets, which is fundamentally incorrect. The manufacturer produces this drug in capsules because this is the only way to ensure the flow of ursodeoxycholic acid into the intestines. It is for this purpose that the finely dispersed substance is packaged in a gelatin shell. From the instructions for Ursosan you can find out that the contents of the capsules are in the form of a powder and include not only ursodeoxycholic acid, but also a number of excipients:

• gelatin,
• titanium dioxide,
• magnesium stearate,
• colloidal silicon dioxide,
• corn starch.

Contraindications

The drug has different effects on different people.

The existing list of contraindications will help avoid the negative consequences of use:

1. Acute inflammatory processes in the gallbladder and bile ducts.
2. The presence of gallstones of various types, with the exception of cholesterol.
3. Infectious lesions of the gallbladder and bile ducts.
4. Functional disorders of the liver and kidneys, liver and kidney failure.
5. Severe cirrhosis of the liver.
6. Hypersensitivity to the ingredients of the drug.
7. ARVI and colds, which are accompanied by high fever.
8. Crohn's disease.
9. Allergic reaction to the components of the drug.
10. First trimester of pregnancy.
11. Children under 3 years of age are contraindicated in taking the drug in capsule form. They are replaced with a similar drug in the form of a suspension or syrup.

Analogs

Ursosan is produced in the Czech Republic and Germany. Pharmacists on the global market offer patients a wide range of Ursosan analogues.

They are created on the basis of the same active ingredient - ursodeoxycholic acid, but their cost is different due to the different dosage of the active component:

1. Ursofalk has two forms of release: suspension for children weighing less than 47 kg and capsules for adults. It effectively dissolves cholesterol stones. The course of treatment is carried out for six months. Sometimes it is extended to a year. Country of origin: Germany. The suspension in Moscow costs 230 rubles, and a pack of 10 capsules costs 200 rubles.
2. Urdoxa is available in the form of capsules. Produced in the Russian Federation. The price of a package of 50 capsules exceeds 700 rubles.
3. Ursoliv is a Russian drug. The cost of a package containing 10 capsules is 160 rubles.
4. Ursodex in capsule form is produced in Russia. For a package of 50 capsules you will have to pay more than 650 rubles.
5. Livodex is available in film-coated tablets in India. The cost of a package of the drug of 50 tablets is 180 rubles.

The choice of drug is carried out taking into account the individual characteristics of the body and sensitivity to auxiliary components, since ursodeoxycholic acid is the main active ingredient of all drug analogues.

Indications for use

Ursosan, like any other medicine, is prohibited from being taken without a doctor’s prescription; self-medication can not only bring no results, but also harm an already diseased liver.

Often, doctors prescribe Ursosan capsules for the treatment of diseases such as:

• the first manifestations of formed stones (cholelithiasis), with the goal of dissolving minor cholesterol stones and preventing their new formation;
• hepatitis (viral, autoimmune, toxic, alcoholic, both acute and chronic);
• low or too active mobility of the biliary tract and the walls of the gallbladder, which is called dyskinesia;
• the process of proliferation of fibrous tissue in the liver;
• with primary biliary liver cirrhosis;
• intoxications of the body that have occurred due to a disorder in the liver;
• chronic cholangitis;
• problems with the gastrointestinal tract, in particular, for the treatment of impaired digestion - reflux gastritis;
• and is also prescribed with the simultaneous use of hormonal, antimycotic, antibiotic drugs that provoke exhaustion and, as a result, liver disease.

Cholecystitis

Cholecystitis is a disease of the gallbladder, which is characterized by its inflammation with changes in the biochemical composition of bile. Inflammatory processes lead to disruption of the outflow of bile and the formation of stones of different sizes. This disease is caused by staphylococcal and streptococcal infections, Klebsiella, and anaerobic Escherichia coli.

Cholecystitis most often affects people who:

• do not eat properly (prone to obesity);
• abuse alcoholic beverages;
• smoke;
• abuse medications.

There are acute and chronic forms of the disease. Acute cholecystitis is caused by a complication of gallstone disease. When the bile duct is obstructed by a stone, inflammation of the gallbladder walls develops due to mechanical irritation.

Signs of acute cholecystitis:

• sudden appearance of intense pain on the right under the rib, which radiates to the right shoulder blade;
• increase in body temperature reaches 40 degrees;
• chills accompanied by heavy sweating;
• feverish condition;
• bitterness in the mouth;
• nausea;
• vomiting that does not bring relief;
• lack of appetite;
• intoxication;
• leukocytosis.

Acute cholecystitis may be accompanied by pancreatitis, hepatitis and cholangitis. As a result of complications of this disease, jaundice, bile peritonitis and liver abscess develop.

A patient with acute cholecystitis is urgently hospitalized in the surgery department for surgical intervention. The presence of contraindications for cholecystectomy involves percutaneous drainage of the gallbladder.

The chronic form of cholecystitis is manifested by the following symptoms:

• heaviness behind the abdominal wall and dull or paroxysmal pain in the right side under the rib;
• feeling of a bitter taste in the mouth;
• increased pain after eating;
• dyspeptic phenomena.

Exacerbation of the disease is accompanied by the same clinical symptoms as acute cholecystitis.

The presence of at least one of the listed symptoms requires urgent contact with a gastroenterologist.

After the initial examination, to confirm the diagnosis, the doctor prescribes certain tests:

1. Ultrasound allows you to determine the size and volume of stones, their location and threat to the patient’s life.
2. The results of laboratory tests of blood and urine reveal inflammation, which is caused by the formation and movement of stones.
3. X-ray irradiation determines congenital pathologies of the gallbladder and bile ducts.
4. The biochemistry of bile is studied using probing.

Pharmacological properties of the drug Ursosan

Ursodeoxycholic acid has a membrane-stabilizing and hepatoprotective effect, protecting hepatocytes from damaging factors. It has immunomodulatory activity, reduces the severity of immunopathological reactions in the liver by reducing the expression of histocompatibility antigens HLA-1 on hepatocytes and HLA-2 on bile duct cells and reducing the effect of immunoglobulins (primarily IgM). Reduces the formation of cytotoxic T-lymphocytes. By stimulating exocytosis in hepatocytes during cholestasis by activating Ca2+-dependent α-protein kinase, ursodeoxycholic acid reduces the concentration of bile acids toxic to hepatocytes (cholic, lithocholic, deoxycholic, etc.). Inhibits the absorption of lipophilic bile acids in the intestine (apparently due to a competitive mechanism), increases their fractional turnover during the hepatic-intestinal circulation; induces choleresis with a high content of bicarbonates, which leads to an increase in the passage of bile and stimulates the excretion of toxic bile acids through the intestines. By replacing non-polar bile acids, it forms non-toxic mixed micelles. By reducing the synthesis of cholesterol in the liver, as well as its absorption in the intestine, ursodeoxycholic acid reduces the lithogenicity of bile, reduces the cholate-cholesterol index, promotes the dissolution of cholesterol stones and prevents the formation of new ones. Absorbed in the small intestine by passive diffusion, and in the ileum by active transport. The maximum concentration in the blood plasma after oral administration is reached after 0.5–1 hour. 96–99% binds to blood plasma proteins. The therapeutic effect of the drug depends on the concentration of ursodeoxycholic acid in bile. About 50–70% of the total dose of the drug is excreted in the bile. In the intestine, it is partially broken down to lithocholic acid, which, during enterohepatogenic circulation, enters the liver and is retransformed into cheno- and ursodeoxycholic acids.

What are the dangers of not having a gallbladder?

A removed sac-like organ is not a reason for pessimistic forecasts, as has been proven by many years of practice used in developed countries. However, this is an unpleasant phenomenon, which requires a long life in a dosed diet regimen and taking the necessary medications.

Failure to follow the prescribed rules invariably leads to undesirable consequences. A person definitely cannot exist without a liver, but without a container for depositing bile secretions, his life is quite real, although not as convenient as before.

The previously used removal with a large surface of invasion, with all its obvious disadvantages, could have an advantage. While in the hospital for a longer period of time to allow internal and external injuries to heal, the patient was constantly under the supervision of doctors. His body had some time to go through the process of adaptation to a new existence, constantly taking medications (the same Ursosan) in the prescribed dosage and being forced to follow a strict diet.

Now you can be discharged in a shorter period, and careful adherence to the recommendations of the attending physician is on the patient’s conscience. PCES can develop in several variants, the most common of which, according to clinical studies, is dyspeptic. It is a natural consequence of the changes that have occurred in the GBS, combined with neglect of taking medications and non-compliance with the prescribed diet.

The pathological mechanism of postcholecystectomy syndrome develops as follows:

• removal of the gallbladder leads to the disappearance from the biliary system of a natural regulator and source of timely supply of bile;
• the specific liquid continues to be produced, but its dosage and timely entry into the intestines are no longer available;
• now bile travels through a smaller circle of circulation, and its supply does not depend on food intake, moreover, it is not processed in the gastrointestinal tract (concentrated and disinfected), but constantly remains in the gastrointestinal tract in its original form;
• caustic acids irritate the intestinal mucosa, leading to an increase in the number of contractions, peristalsis increases;
• the irritating ability of fatty acids leads to the development of diarrhea, changes in the color and composition of feces (from brownish or brownish-yellowish to greenish-yellow, the appearance of loose stools with various inclusions);
• diarrhea continues for a month after cholecystectomy, until a comprehensive method of adapting the patient to the new condition leads to normalization of the gastrointestinal tract.

If measures are not taken or are insufficient, a dyspeptic variant of postcholecystectomy syndrome develops. A person is constantly thirsty, loses weight, develops fever and pain in the abdomen and liver. He is not able to fully digest food, which is why the development of chronic or potential pathologies begins. Muscle cramps are inevitable due to dehydration and the removal of valuable components before they have time to be absorbed and distributed.

Ursosan for cholecystitis

Cholecystitis is a disorder manifested by inflammation of the gallbladder tissue and changes in the qualitative composition of bile. Pathology contributes to stagnation of secretions in the body and the appearance of digestive problems. Untimely treatment of cholecystitis threatens the development of cholelithiasis.

Larisa, 33 years old

I bought Ursosan for the treatment of cholestasis. I thought that an expensive drug would finally help me cope with the problem. I observed positive changes in myself after the course of therapy: heaviness in the area of ​​the right rib disappeared, stool returned to normal. I was very disappointed when, after stopping treatment, my previous problems returned. The second time I drank Ursosan for a long time (about 4 months) in the hope that during this time positive changes would occur in the body. But I felt better only during treatment. I don’t see the point in giving that kind of money to mask the symptoms of the disease.

Rinata, 24 years old

I felt problems with my liver after taking antibiotics. I felt very strong pain on the right side and consulted a doctor. He said that I had acute cholecystitis and prescribed Ursosan to drink. The drug quickly relieved me of discomfort and pain. Now I take it every time after antibiotic therapy.

What is gastritis with high acidity?

Acidity has its own designation – pH. Its level in the stomach should not exceed 3-3.5. Acidic and fatty foods can upset the pH balance. Gastritis can be triggered by both an unhealthy lifestyle and the influence of internal factors. Increased acidity mainly occurs in young children and young people, who are more susceptible to irregular and unhealthy diets.

With long-term chronic gastritis, severe complications can manifest themselves, for example, peptic ulcer. One of the serious problems with gastritis is self-medication and the use of traditional medicine. As a result of such a neglectful attitude towards health, a serious gastric disorder can occur, causing organ atrophy.

The chronic form of the disease is considered quite common, because today half of the world's population suffers from it. In most cases, the disease is discovered without any apparent cause or symptoms.

Causes of excess production of hydrochloric acid

The main provocateur of inflammatory processes in the gastrointestinal tract is considered to be the bacterium Helicobacter pylori, which is capable of multiplying inside the stomach for a long time, increasing acidity. For the infection to begin its destructive effect, several factors are enough: an unbalanced diet, abuse of fried, spicy foods, alcohol and caffeinated drinks. Stressful situations can weaken our immune system and trigger the proliferation of Helicobacter bacteria.

Acidity can be increased due to internal factors: thyroid diseases, diabetes, gout and oxygen starvation. The influence of duodenogastric reflux cannot be ruled out, as a result of which alkaline intestinal contents and bile penetrate into the stomach, causing additional damage.

A healthy mucous membrane is a powerful and strong defense system that can prevent the aggressive effects of negative factors. But even such “protection” can fail and create a favorable environment for the proliferation of bacteria, the appearance of inflammation and erosion. Various types of overwork, genetic predisposition and chronic diseases can affect the functioning of the mucous membrane.

Symptoms

The disease remains undetected by the patient for a long time. Pain rarely bothers a person. There may be a bitter taste in the mouth, belching of bile, or even yellow saliva. Heaviness in the stomach after eating, rumbling, and flatulence may bother you. A sick person's stool becomes unstable, constipation alternates with diarrhea. You should know that atrophic gastritis often develops into oncological pathology.

Therefore, the patient is recommended to consult a doctor at the slightest ailment in the digestive system in order to prevent the disease from developing into cancer. Treatment of reflux gastritis should be carried out under the supervision of a gastroenterologist.

Can it be used during pregnancy?

According to the official instructions for use of Ursosan, it can be used during pregnancy if the benefits of the drug for the mother outweigh the possible risks of developing pathology in the fetus.

The statement is based only on the lack of clinical data on the effect of Ursosan on fetal development. Laboratory studies on the effect of the drug on fetal development in animals did not reveal any negative effects.

Clinical trials were conducted in Germany: pregnant women with severe diseases of the hepatobiliary system were observed, to whom Ursosan was prescribed for health reasons. After the treatment, no harmful effects from taking the drug for the fetus were identified.

Based on research, scientists from France and Germany came to a documented conclusion: Ursosan can be used during pregnancy in the following cases:

• itching of pregnant women due to impaired bile excretion;
• disturbances in the outflow of bile when the gallbladder is compressed by an enlarged uterus;
• chronic processes in the liver, accompanied by poor health and laboratory changes in the blood.

Although this document has not been tested in Russia, Russian obstetricians and gastroenterologists quite widely use Ursosan during pregnancy.

Reviews from patients who took Ursosan during pregnancy are mostly positive. The drug is prescribed for various diseases of the hepatobiliary system.

The few negative reviews are mainly related to the unsuccessful treatment of cholelithiasis, as well as the only negative review for the treatment of severe liver damage with sharply altered laboratory parameters.

Analogues of the drug

Similar drugs in a dose of UDCA 250 mg are: Ursofalk, Grinterol, Urdoxa, Ursodez.

Drugs that have different active ingredients from Ursosan, a different mechanism of action, indications and contraindications, but a similar therapeutic effect - Allohol, Phosphogliv, Heptral.

Analogues of Ursosan

Analogues as an alternative

10 capsules of Ursosan cost on average from 141 to 562 rubles, 10 tablets - from 356 to 456 rubles.

The medicine has many analogues that have the same active substance and the same contraindications, but differ in the additional components included, release forms and cost. The table provides general information about the most effective hepatoprotectors that can replace Ursosan during pregnancy.

If Ursosan was prescribed during pregnancy, but for some reason it did not suit the woman, the doctor may recommend Ursosan analogues to her. These include the following medicines:

• Grinterol;
• Pms-Ursodiol;
• Ursodeoxycholic acid;
• Ursolysin;
• Ursomax;
• Ursonost;
• Ursofalk;
• Ukrliv;
• Ursodex;
• Ursolak;
• Ursohol;
• Choludexan.

Detected side effects, a reaction of immunity to individual components of Ursosan, are not a reason to search for an analogue and purchase it on the advice of an incompetent person or even a pharmacist at a pharmacy.

The search for a drug with a similar effect is also carried out by a doctor. For example, if it is necessary to provide a protective effect on the liver, Hofitol, which contains only artichoke plant extract, can be prescribed. There is no point in replacing Ursosan with any other drug from the series containing UDCA, so a drug from the drug series with another active ingredient is being looked for.

What is better and more effective in comparison with Ursosan, what is the difference

Preparations containing UDCA differ in manufacturer and country of production, including the active substance. These factors determine the price of the final product.

Ursofalk

The active ingredient of Ursofalk is also UDCA. The drug is available in capsules (250 mg) and suspension (5 mg). Country of origin: Germany.

Patients who had to take both drugs did not notice a difference in their action and could not say which was better - Ursosan or Ursofalk.

Considering the mechanism of action, indications and contraindications of Ursosan and Ursofalk, it is almost impossible to say which is more effective. True, some doctors, based on their own experience, note that the effect of using Ursofalk occurs faster.

What really is the difference between the drugs Ursosan and Ursofalk is in the forms of release of the drugs. Ursosan is available in capsule (250 mg) or tablet (500 mg) form. Ursofalk, in addition to the capsulated form (250 mg), has the form of a suspension, which makes it popular in pediatrics. The drugs vary greatly in price, which is especially important for long-term therapy.

Grinterol

The active ingredient of Grinterol is UDCA, produced in capsulated form of 250 mg. All pharmacological actions of the drugs Ursosan and Grinterol are identical.

There have been no special clinical studies that could reveal which is better than Ursosan or Grinterol. The only difference between the drugs is the country of origin. Grinterol is produced in Latvia.

Urdoxa

The active ingredient in Urdoxa is UDCA. The drug is produced in capsules of 250 mg. Country of origin: Russia.

To decide for yourself which is better - Urdoxa or Ursosan, patient reviews are unlikely to help. UDCA for Urdoxa is imported from China, and the medicine itself is “assembled” at a plant in Obninsk. This is also due to the fact that the price of this drug is slightly lower than Ursosan, but the difference is insignificant. The consumer should take this fact into account when choosing a medicine.

Ursodez

The active ingredient is UDCA. Release form: capsules of 250 and 500 mg. Country of origin: Russia.

When answering the question of which is better - Ursosan or Ursodez, you should also pay attention to the origin of the active substance - UDCA. To make Ursodez, it, like Urdoxa, is imported from China, and the drug itself is “assembled” at a factory in the Leningrad region.

When answering the question of which is better, the consumer should decide for himself what he wants to be treated with - an Italian or a Chinese active ingredient.

Livodex

The active ingredient is UDCA. Country of origin: India. The question of which is better – Livodex or Ursosan – can be answered by comparing their characteristics. The drugs are identical in their pharmacological properties: mechanism of action, indications, contraindications. Patients taking both medications did not notice any difference in the therapeutic effect. The dosage of the drugs is different: Ursosan - capsules 250 mg, tablets - 500 mg, Livodex - tablets 150 and 300 mg.

Thus, the volume of the active substance is different. The number of additional components in Livodex is greater. The cost of Livodex is almost half that of Ursosan, despite the fact that the raw materials for both of them are supplied from Italy. Negative consequences of administration, such as dyspepsia and allergic reactions to drug components, are rare.

Allohol

Allochol is a herbal medicine that has a choleretic effect and is used in the treatment of pathologies of the hepatobiliary system. The drug stabilizes bile formation and bile transport, enhancing intestinal motility, reducing putrefactive and fermentative processes.

To decide which is better - Ursosan or Allochol, you must remember that Allochol is a choleretic drug, and Ursosan has a complex effect (hepatoprotective, hypolipidemic, cholelitholytic, immunomodulatory). Allochol is used for pathologies of the biliary system, preventing stone formation and cholestasis.

Ursosan, although it has a choleretic effect, is used for diffuse liver diseases, preventing the death of hepatocytes and slowing fibrosis of the liver tissue. Also prescribed for cholelithiasis to remove cholesterol stones.

Phosphogliv

Phosphogliv is a hepatoprotector with antiviral and immunomodulatory effects. Active ingredients: glycyrrhizic acid and plant phospholipids.

According to the official instructions, phospholipids restore the structure and function of cellular and intracellular membranes, thereby preventing cell death. Taking phospholipids helps increase the enzymatic activity of the liver.

Although phospholipids are still prescribed for hepatobiliary diseases, their effectiveness is currently questionable. Thus, it has been shown that with long-term use, drugs based on them can themselves lead to the accumulation of lipids in hepatocytes and to fatty liver.

Ursosan is used for the treatment of cholelithiasis and the prevention of its relapses, for non-alcoholic lesions of the hepatobiliary system, and for liver diseases caused by stagnation of bile.

When choosing which is better - Phosphogliv or Ursosan, they often choose the latter, since the effectiveness of drugs based on phospholipids is questionable.

Heptral

Heptral is a hepatoprotector with antidepressant activity. The active ingredient is ademetionine. Heptral, as noted in the instructions for use, has choleretic and cholekinetic characteristics. It has an antioxidant and neuroprotective effect.

Two studies were conducted in China and Germany with small sample populations. The effect of two hepatoprotectors - Heptral and Ursosan - was compared for bile stagnation in pregnant women, and it turned out that Ursosan is more effective for this pathology.

American and European hepatologists consider the following effects of Ursosan as a hepatoprotector to be proven:

• prevents the progression of biliary cirrhosis;
• destroys gallstones and prevents their recurrence;
• gives a good effect in the fight against non-alcoholic liver pathologies.

Heptral, which has been proven, increases survival in stage I-II cirrhosis; in the last stage of cirrhosis, it is not effective. Other positive properties of Heptral have not been clinically confirmed. Based on this, Ursosan, as a hepatoprotector, is better than Heptral.

Review of reviews from patients who took the drug

Reviews from patients who took Ursosan for a variety of diseases are mostly positive. Negative reviews, of which there are few, relate to side effects from taking Ursosan, the main of which are dyspeptic disorders and stool instability.

Reviews from doctors regarding the use of Ursosan are positive. They talk about good results when using the drug in the treatment of cholelithiasis. In addition, the drug in question has a proven hepatoprotective effect, unlike products that do not contain UDCA.

Positive reviews

Ursosan/ursofalk for two years and the stone came out. For chronic cholecystitis, I take one drink every three months and it helps.

It helps me a lot; I had my gallbladder removed a year ago. After 8-9 months. After the operation, problems with stool appeared. The doctor told me to take Ursosan, I need it vitally, as she said. I drink it regularly, without breaks. EFFECT WITH HURRAY. Helps disperse bile in the outflows

One of the best drugs, in my opinion. I took it after an intensive course of antibiotic therapy, before it there was another hepatoprotector, quite well-known, which everyone praised me, but only ursosan really helped, because under that, some kind of reaction to the antibiotics began, at first a bitterness appeared in the mouth, well, I was scared, After all, the liver is a serious matter, then the doctor replaced that drug with Ursosan, I don’t understand why she didn’t prescribe it right away! I completed the course successfully, took Ursosan for another week or so, my liver was completely restored, now I eat as before - whatever I like. By the way, I still take Ursosan periodically, for prevention, and the food I eat now is like that – the liver is still under load, and it triggers regenerative processes in it.

My husband suffers from an incurable liver disease. The doctor prescribed him to take hepatoprotective drugs, including the drug Ursosan.

It has a choleretic effect, reduces cholesterol levels in bile, which helps destroy gallstones and prevents the formation of new ones. Ursosan also has an immunomodulatory effect.

My husband has been taking Ursosan for 6 months now. Liver tests have improved. Even the yellowness of the skin and eyes has decreased. This means taking Ursosan has a positive effect.

This drug must be taken for a long time to achieve a sustainable effect. My husband was told that he must drink Ursosan for life.

The drug is not cheap. But it’s good that Ursosan or its analogues Ursodez, Exhol are given free of charge to disabled people.

I was prescribed Ursosan, which in my opinion is a good drug. In any case, it affected my health in the most positive way. I’m going on vacation in a week, and I’ll continue to drink it there - as a preventive course and to protect the liver from vacation excesses.

When there were problems with antibiotics, it helped a lot. The problem was that I almost brought myself to cirrhosis! It’s good that I noticed changes in my body and went for tests. Although I always took them for 2 weeks. They said that for some reason my liver was damaged anyway. Allegedly due to nutrition, and antibiotics finish it off. In general, I cured everything with Ursosan, now I sometimes take it for prevention. God saves man, who save himself

There was crushing of kidney stones. quickly relieved inflammation after the procedure and partially relieved pain. A good soft drug that helped me a lot. Now I take the course every six months to prevent stones from forming again.

Helps with jaundice in newborns.

There are contraindications and side effects.

The day after the birth of my daughter, during a round, the pediatrician noticed that the baby was yellow. I checked it with some kind of device and in fact the bilirubin turned out to be higher than normal. My daughter lay under the lamp for three days, but her bilirubin did not decrease.

When we were discharged home, the local doctor came. She prescribed Ursosan for us. This drug is sold in capsules. I opened the capsule and divided the powder into 4 parts. I diluted 1/4 of the portion with water and gave it to my daughter with a teaspoon. The water was very bitter, but the child drank it calmly.

The doctor also told me that sunbathing is beneficial for jaundice. Even though it was winter, it was just in those days that it got a little warmer. When the sun shone directly through our windows at lunchtime, I undressed the child and put her on the sofa in front of the window.

So in a few days, with the help of the sun and the medicine Ursosan, we got rid of jaundice.

After the removal of the gallbladder, I began to suffer from hunger pains at night and attacks. After passing the examination, the doctor prescribed Ursosan to me. As it turned out, bile spills into the stomach, and then into the intestines, which causes hellish pain. With the help of these capsules, the bile became less concentrated and after a couple of months the pain disappeared. Unfortunately, I recently drank an analogue and the attacks reappeared, so now I only drink Ursosan. Of course, it turns out to be very expensive, but at night I sleep peacefully.

Latin name: Ursosan. Manufacturer: PRO. HONEY. CS Prague (Czech Republic).

Doctors about the drug: which is better among analogues, side effects and effects, what helps.

Active substance

: Ursodeoxycholic acid

DO YOU STILL THINK THAT IT IS HARD TO CURE YOUR STOMACH?

Judging by the fact that you are now reading these lines, victory in the fight against diseases of the gastrointestinal tract is not yet on your side.

Have you already thought about surgery? This is understandable, because the stomach is a very important organ, and its proper functioning is the key to health and well-being. Frequent abdominal pain, heartburn, bloating, belching, nausea, bowel dysfunction. All these symptoms are familiar to you firsthand.

But perhaps it would be more correct to treat not the effect, but the cause? We recommend reading the story of Galina Savina, how she cured her stomach. Read the article >>

Compatibility with alcohol, consequences of simultaneous use

Ursosan is taken for a long time, sometimes several years, so the question of the compatibility of Ursosan and alcohol often arises among patients, and this worries not only people with alcohol addiction.

The official instructions for use of the drug do not cover this issue in any way. However, practicing therapists and gastroenterologists speak unequivocally negatively about the combined use of Ursosan and alcohol. This is due to the fact that drinking even a small amount of alcohol negatively affects the function of the hepatobiliary system, nullifying all the efforts of doctors.

Although there are no consequences from the combined use of Ursosan and alcohol, taking ethanol itself can aggravate the course of hepatobiliary pathology.

Advantages and disadvantages

Among the advantages of Usosan in the treatment of jaundice and other specialized diseases are:

• prevents relapse of the disease;
• available for purchase at any pharmacy;
• powerful medicinal effect.

The drug also has disadvantages that are actively discussed by consumers:

• the high price of Ursosan - there are many cheaper analogues, which are slightly inferior in effectiveness to Ursosan;
• side effects of Ursosan occur quite often, especially with long-term use. In most cases they are not serious and are often associated with diarrhea.

Negative reviews

I had my gall bladder removed, was prescribed to take Ursosan, took it for three years, then pain on the right side began to appear periodically. The doctor advised to replace the drug with an analogue - Ursodez. Apparently, during the process of taking it, something in the body changed and an intolerance to something in the composition of Ursosan appeared.

Negative. I have biliary dyskinesia, an ultrasound showed the presence of small stones in the gall bladder, the doctor advised using Ursosan to dissolve cholesterol stones. I took Ursosan in the form of 2 capsules at night. After some time I noticed a sharp increase in pressure to 150/70, although I have been hypotensive throughout my life and my normal blood pressure is low, in the range of 110-120, my condition was disgusting, I started taking medication for my blood pressure, and after stopping Ursosan, my blood pressure immediately returned to normal. The doctor agreed with stopping Ursosan.

The doctor prescribed the drug for me, I have cholesterosis, 3 drops at night, after 2 weeks of taking it, my hemorrhoids were restored

After two weeks of taking it, my hair began to fall out in batches. At first I didn’t know what to think, then I read about the side effects. Before buying the whole course, I should have tried it on a small package, now it’s lying around in the cabinet.

I was diagnosed with Cholesterosis (2 small polyps 1 and 2 mm), Ursosan was prescribed, 1 drop. in the evening after eating.

When taking it on the 3rd day, an allergic reaction began: redness of the face, tingling, burning of the eyelids, by the evening the joints began to ache, the medication had to be stopped. The doctor recommended taking Eubicor or Rekitsen-rd in parallel, which should relieve side effects, but I doubt it.

Benefits: Didn't cause harm, temporarily eliminated problems

Flaws:

Price, does not eliminate the cause of the disease, the effect disappears after stopping use

I bought an expensive drug, full of hopes that I would finally get rid of the problems with cholestasis forever! Yeah, it's not like that. At first, everything went well - after two or three weeks of taking it, the jaundice disappeared, the pain in the right hypochondrium also disappeared, the indigestion stopped bothering me, the stool returned to normal, in general, everything was fine. I drank for a month, well, I think that’s all, I won’t need any more treatment. What a disappointment I was when, after stopping the drug, not even two weeks had passed, when the characteristic pain made itself felt again - at first it was very weak, and then began to intensify. I started drinking Ursosan again, this time I drank for 4 months (I thought I didn’t drink for long the first time, but it didn’t help at all). Everything got better for me again, while I was drinking, I had no problems. But as soon as I stopped taking it, everything started again! What does it mean? This means that the drug does not restore the liver itself, but simply temporarily removes bile, and that’s all. Well, since the source of the problems is not eliminated, the disease will still return, so why spend so much money for such an effect?

Flaws:

Cost, did not help, caused side effects

I still don’t understand how it can help with biliary reflux esophagitis, but I didn’t argue with the doctor and started drinking. It is very easy to check the effectiveness of the drug for my illness - when the acid belching, flatulence, stomach pain stop and the constant bitterness in the mouth disappears - then we can assume that the drug has helped. But in the case of Ursosan, I didn’t expect this - not that all this did not disappear, at least it didn’t even become weaker! But I didn’t drink it for a couple of weeks, or a couple of months—I took everything prescribed for six months! I kept believing that it would help, I believed the doctor’s assurances, and I spent a lot of money. In addition to wasting money, there was another problem - after 3 months or so, I periodically began to experience severe constipation, which then suddenly gave way to diarrhea. It turned out that these were side effects from Ursosan, and not errors in nutrition. In general, I spent the money and did not get any benefits, and my intestines were upset - I will not advise anyone.

Ursosan-6 months. 15 tons of treatment down the drain, not a single stone has shrunk by an ounce, the head doctor said that he has never met a person whose stones dissolved from ursosan.

Take care of your money.

A CURSE TO PHARMACEUTICALS AND SCAMMERS

They will only try to get money from sick people so that you are empty and the stones do not pass you by

I have thickened bile. I was prescribed Ursosan 2 tablets at night. After 3 days of treatment, I had a leak of bile into my stomach and now gastritis has begun. I feel nauseous all the time and can’t eat anything. This is how Ursosag treated one thing and got another sore!

I have biliary dyskinesia. I contacted a gastroenterologist and she prescribed me this drug. Considering the price of other drugs, it is terribly expensive. But that’s not so bad, this “Ursosan” is not effective, it may have helped someone, but not me. And I took the medicine for about four months, and this is taking into account the fact that I still do not have stones in the gall bladder, but only thickening, the content of an echo suspension, and the instructions say that it even crushes the stones. In general, when I took it I hoped it would help, but it only made me sick. I still haven't solved my problem. Just like that! Now I'm drinking choleretic herbs. Hope it helps.

Advantages:

- didn’t find it

Flaws:

expensive, terrible nausea as a side effect, large tablets with an unpleasant odor and taste

Oh, now I’m writing and shuddering from the “pleasant” memories. This fall, an unpleasant thing happened to me again - an exacerbation of biliary dyskinesia. Hypomotor type, biliary sluggishness, round-the-clock dull aching pain, nausea, taste in the mouth. In general, it’s not very pleasant. The gastroenterologist prescribed it along with the rest of the course of treatment, as there was stagnation on the face. According to the ultrasound, everything is clear, there are no stones, but the bend in the gallbladder has not gone away.

The first shock was a visit to the pharmacy. A box of one hundred pieces cost about 1,500 rubles. I carried it like crystal all the way home through the icy conditions. Suddenly, what, one and a half pieces))).

The second shock was reading the annotations and side effects.

The third shock came in the morning. Vomit. Unceremonious vomiting. All day down the drain. I convinced myself that I was not dying and that this was temporary, but I felt bad all day. The nausea did not go away and stood in a lump in my throat. I finally decided to take a proven anti-nausea medication, but it didn't help.

I lived in a fog for 4 days. Every day the heaviness in the hypochondrium increased, I wanted to sleep constantly and my condition was a vegetable one. I even forgot to take a magic capsule at night. And in the morning I didn’t feel so sick. It was then that it became clear what was going on. The box was pushed into the far corner. What should we do next with her now?)))

I couldn't rate them

constipation that cannot be relieved by anything

The drug was prescribed to me by a doctor with a vague diagnosis of “Functional gastrointestinal disorders”, a history of reflux esophagitis and bile duct dyskinesia.

The intake was designed for 1.5 months, 1 capsule per night. Having bought the medicine, I calculated that one capsule costs 100 tenge (20 rubles, approximately). I took 50, since the capsules are packed in blisters of 10 pieces.

To judge objectively the work of a particular medicine, tests and examinations are needed “before” and “after”. Frankly, neither one nor the other was prescribed to me, but I am writing this review to highlight a side effect that almost drove me crazy

Although the “side effects” section is classified as rare, in my case, it was so apt! I highlighted two manifestations that I noticed in myself, but the nausea did not torment me much. Usually I started feeling nauseous almost immediately after taking the pill, but I quickly fell asleep and didn’t feel anything.

But I was overcome with intestinal problems. Moreover, I didn’t immediately figure out how to connect constipation and Ursosan. After suffering for a month (!), I thought to look at the instructions and voila! Having immediately stopped Ursosan, my intestines began to “thank me”.

So, dears, if you have problems with regular bowel movements, ask your doctor how to deal with this while taking Ursosan. Although neither Duphalac, nor magnesia, nor water, nor laxative food helped me, but ONLY withdrawal!

Interaction of Ursosan with other drugs

• Ursosan is not recommended to be taken in parallel with antacids and cholestipol. Getting smectite and aluminum hydroxide into the stomach leads to the binding of ursodeoxycholic acid and a decrease in the medicinal effect of Ursosan. If it is impossible to exclude these medications, you must take them two hours before or after Ursosan.
• Ursosan increases the absorption of cyclosporine, so the combination of these two drugs requires dose adjustment of the latter.
• Ursosan reduces the bioavailability of nifedipine. After a blood test, its dose is revised upward.
• Taking medications containing estrogen promotes the rapid formation of cholesterol stones, which makes treatment with Ursosan ineffective.

Side effects

Ursosan, like any other drugs, has a number of side effects.

• Nausea
• Vomit
• Regurgitation
• Diarrhea
• Allergic reactions.

The symptoms are not long-term and disappear when you stop taking the drug and strictly follow the instructions.

The following side effects were observed in some patients taking Ursosan during clinical trials:

• the occurrence of acute pain in the abdominal cavity, which may subside over time or manifest itself on an ongoing basis;
• allergic reactions;
• calcification of gallstones;
• diarrhea;
• the level of activity of liver transaminases increases;
• the occurrence of vomiting;
• nausea.

Synonyms and analogues

For the treatment of the diseases and pathological conditions listed above, you can use not only Ursosan, but also its synonyms and analogues. All these drugs have identical or similar effects.

Synonyms

This group includes medicines that have ursodeoxycholic acid as an active ingredient:

• Livodex tablets;
• Ursodeoxycholic acid;
• Urdox capsules;
• Ursodex tablets;
• Capsules and suspension Urso 100;
• Ursodez capsules;
• Ursor C capsules;
• Ursosliv capsules;
• Rompharm Ursor capsules;
• Horodexan capsules;
• Ursofalk suspension and capsules;
• Exchol capsules.

Livodex Ursodex Ursodez Exchol

Despite the same active ingredient, you should not independently decide to replace the prescribed drug with another. Different drugs in this group have many options for the current dosage, so your doctor should draw up a treatment program, selecting the frequency of dosing and calculating the optimal duration of the course of treatment.

In addition, drugs from different manufacturers may be absorbed at different rates and contain specific elements to which patients may have a negative response.

Ursosan is produced in Germany and the Czech Republic, its composition is strictly verified and does not contain unnecessary, non-functional elements. The drug has passed all the required tests and inspections, and the components undergo multi-stage purification to remove impurities.

Urdoxa, in turn, although it is a Russian-made generic of Ursosan, the domestic pharmaceutical company that produces it purchases all active and auxiliary substances in Europe. Thus, the effect of both drugs will be identical, only their cost differs.

Generics from other manufacturers are created from components that have not been purified from chemical impurities, so side effects may occur when taking them. They can also be strengthened by the composition of the shell along with excipients: many inexpensive tablets and capsules dissolve ahead of time, delivering a shock dose of UDQ to the stomach and initial parts of the intestines.

Experts are increasingly using Ursofalk to dissolve gallstones. During practical research, many doctors note that the drug is easier to tolerate, while its effectiveness sometimes exceeds the positive dynamics from treatment with Ursosan.

Analogs

This category of drugs has other active ingredients in its composition, but at the same time they have the same therapeutic choleretic effects as Ursosan. Modern pharmaceuticals offer only 2 analogues of this drug:

• Allochol is a Russian drug based on plant components and natural enterosorbents. The active ingredient is condensed bile, which has long been used in folk medicine to treat diseases of the gastrointestinal tract and liver;

• Cholenzym - choleretic tablets that normalize digestive processes. The basis of the drug is made up of natural ingredients of animal origin: dried bile and pancreas, as well as powder from dried mucous membranes of the small intestine.

These analogues are not able to fully replace the complex action of Ursosan, therefore replacing a prescribed drug containing UDCA with them is only possible if the therapy requires exclusively a choleretic agent. Before including one of these tablets in your therapy program, you should consult your doctor.

How to replace Ursosan

The drug Ursosan for newborns is not sold in every pharmacy. However, if necessary, you can replace the composition with analogues with identical composition. In some cases it is allowed to use:

• Ursofalk - suspension for newborns. The drug is also available in capsules.
• Urdoxa, Ursoliv, Ursorom Rompharm, Urso 100, Urgsodez - capsules.
• Ursodex, Livodex - tablets.

Jaundice in newborns rarely requires serious therapy. As a rule, just taking Ursosan is enough.

If a complication arises and the baby’s condition worsens, then immediate hospitalization and further treatment of the pathological phenomenon in a hospital setting and under the supervision of doctors is required.

Neutral reviews

I take Ursosan. I was found to have two small stones in my gall bladder, so the side effects were immediately reported...diarrhea is one of them :)) but it doesn’t bother me much :)) the course was divided into three doses (ursosan 250 mg) for my weight 70 kg 3 tablets ….the higher the dose the likelihood of diarrhea is high…so my doctor reported it. I take it in the first half of the day (8 a.m. 12 noon and 5 p.m.) when I don’t have any other medications... I take others in the morning and evening... so as not to burden the body... and everything goes well... I have to stick to my diet, comrades... fatty smoked sweet for the night, etc. refuse...otherwise you will waste money and time. I will continue to broadcast...I’ve only been taking Ursosan for a month now. Problems: diarrhea does not bother me...occasionally. If the diet is violated, I observe pain in the right hypochondrium. I relieve the spasms with a spasgan or a spa. The rest is still normal..I will do blood biochemistry during this period or other tests for comparison. be healthy

Good afternoon. I took Ursosan for more than a year (about a year and a half, I don’t remember exactly). One ultrasound showed that there were three stones, and two other ultrasounds showed that the gall bladder was one-third full! All the stones were small and mobile (when they “twisted” me during the ultrasound, they literally “spread through the gallstone”). Initially, doctors said that you might have to take Ursosan for years, and that it would hardly help - nothing concrete. Apparently, the medicine began to “drive away” the stones and, moreover, apparently they were of a cholesterol nature, and small ones at that. I had frequent attacks of dull heaviness in the epigastric area. Sometimes they passed quickly, sometimes I suffered for a whole day (the attacks began about an hour after eating food, even with a tiny amount of any fat or oil). I think that the stones not only dissolved, but were also expelled from the gall bladder, and the severity was due to clogged ducts.

The gallbladder on ultrasound was filled to 100% of the lumen with gallstones. After taking Ursosan for 4 months, less than 10% of the stones remained. I stopped taking Ursosan due to the high cost of treatment!

The nausea disappeared and small stones dissolved, but not all. But the large stone remained.

Advantages: No side effects, effective

Flaws:

Very expensive, temporary effect

I have been drinking for 4 years as a preventive measure - in courses of 2 months, several times a year. Before this, I already had stones, I had to go for crushing - the procedure is terribly expensive, and the stones then come out with terrible pain due to the sharp edges. I was never able to cure my dyskinesia, so there was still a risk of re-formation of stones. Ursosan also did not eliminate the disease, its effect is temporary, but while you drink it, it acts effectively and improves the functioning of the biliary tract - in general, it neutralizes dyskinesia for a while. Thanks to this, bile does not stagnate in the gallbladder, therefore, the risk of stone formation disappears. Of course, a lot of money is required for constant treatment with Ursosan, but where can one go - I haven’t found anything more effective yet. Every six months I go for an ultrasound, and so far there is not even sand, let alone stones - the drug works, there are no side effects, and thank you for that.

I started drinking Ursosan for pain in the right hypochondrium. The doctor prescribed it after an ultrasound, having discovered a bend in the gall bladder. As soon as I started drinking, the pain stopped, but another problem appeared - terrible diarrhea. I am in shock, hugging the toilet all day, and besides, I have a temperature that jumps throughout the day to 37* and back. I decided to take a break from taking the drug.

Advantages:

Wide spectrum of action

Flaws:

There is a cheaper analogue

I noticed this drug when I was in the hospital with gastritis. There, all the walls were covered with posters with the drug “Ursosan”. As a result, I decided to buy them.

I've been taking them for 2 months now and I feel good. It’s really not a bad remedy for protection and prevention, as well as for the treatment of serious diseases.

But you still need to take it as prescribed by a doctor, because the drug is strong and effective.

It also has serious side effects, so get tested before you start taking it.

Never self-medicate, especially in such serious cases.

The drug "Ursosan" is not cheap, but there is also an analogue "Ursofalk" - the only difference is the price. Therefore, what you accept is up to you to choose.

I was prescribed Ursosan when I was undergoing antibiotic treatment. As the doctor explained - to protect the liver. I can’t say that I noticed dramatic changes in my health, but it didn’t get any worse. Usually, when taking antibiotics in the morning, I have a bitter taste in my mouth and nausea, but this time I did not notice any such signs. In general, it seems to me that Ursosan helped me.

Ursosan price, where to buy

This medicine can be bought in Ukraine, Belarus and Russia. How much this drug costs depends largely on the number of capsules in one package. Average price of Ursosan in Ukraine:

• capsules of 50 pieces per package – 370 hryvnia;
• capsules of 100 pieces per package – 640 hryvnia;
• capsules of 10 pieces per package – 70 hryvnia.

The cost of the drug in Minsk and other cities of Belarus:

• capsules of 50 pieces per package - approximately 300 thousand Belarusian rubles;
• capsules of 10 pieces per package - approximately 70 thousand Belarusian rubles.

You can buy this product in Moscow and other Russian cities at the following prices:

• price Ursosan 100 tablets (250 mg) – approximately 1400 rubles;
• price of Ursosan 50 capsules - approximately 770 rubles;
• the price of a package of 10 capsules is approximately 180 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Ursosan caps. 250mg n10Pro.Med.Cs
• Ursosan caps. 250 mg n100PRO.MED.CS Praha j.s.
• Ursosan caps. 250 mg No. 50ZiO-Zdorovye ZAO

Pharmacy Dialogue

• Ursosan (caps. 250 mg No. 10)
• Ursosan (caps. 250 mg No. 50)
• Ursosan (caps. 250 mg No. 100)

Europharm* 4% discount using promo code medside11

• Ursosan capsules 250 mg n50Pro.Med.CS/Zio-Zdorovye
• Ursosan capsules 250 mg 100 pcs. PRO.MED.CS Prague j.s. CZ

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Pharmacy24

• Ursosan 250 mg No. 100 capsules PRO.MED.CS Prague a.t., Czech Republic/ PRO.MED.CS Prague a.s., Czech Republic

PaniPharmacy

• Ursosan capsule Ursosan caps. 250 mg No. 50, PRO.MED.CS Prague
• Ursosan capsule Ursosan caps. 250 mg No. 100, PRO.MED.CS Prague

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Operating principle

Ursosan represents a group of drugs called hepatoprotectors. This drug not only protects liver cells from harmful influences (drugs, toxins, bile acids, fatty foods, etc.), but also:

• stimulates the secretion of bile;
• lowers cholesterol and harmful fatty acids;
• promotes the destruction of cholesterol stones;
• activates the secretion of digestive secretions;
• has an immunostimulating effect;
• prevents the development of liver fibrosis.

Thanks to the use of tablets or capsules, the flow of bile improves and small stones formed in the bile ducts are removed. The drug slows down the aging of liver cells and has a positive effect on their functions.

Terms and conditions of storage

Store in a dry, dark place at a temperature of 15 to 25 °C. The shelf life of tablets is 3 years, capsules are 4 years.

Capsules should be kept in a dry place, out of reach of children and well protected from sunlight. The optimal temperature regime is up to 25°C.

Four years.

Ursosan is stored in a cool place, away from direct sunlight. It should also be inaccessible to children so that they do not inadvertently take pills that were not intended for them. Subject to these conditions, the shelf life of Ursosan can be up to 4 years from the date of manufacture.

Ursosan must be kept in a dry place, away from direct sunlight and away from children. The temperature should be maintained at 15˚C-25˚C. Shelf life: 4 years.