Trimedat - official instructions for use (in tablet form), indications, taken before or after meals, analogues are cheaper

Trimedat instructions for use describe it as an antispasmodic drug used for the treatment of gastrointestinal diseases of the corresponding nature. Often people neglect the significance of this liner. And you should always familiarize yourself with its contents before purchasing the medicine. The essence of the description of the drug Trimedat: instructions for use, price, reviews of the drug, positive and negative, will be discussed below to help the potential buyer in choosing the remedy he needs.

Instructions for use of Trimedat tablets

Trimedat tablets should be swallowed whole and washed down with plenty of water. For adults and children over twelve years of age, Trimedat is prescribed orally at a dose of 100-200 mg three times a day. To prevent relapse of irritable bowel syndrome after a course of therapy, during the period of remission, you should continue taking the medication at a therapeutic dose of 300 mg per day for twelve weeks.

According to the instructions, the use of Trimedat in the form of a suspension is prescribed according to the following scheme:

• children under six months of age - half a teaspoon two to three times a day;
• children from six months to one year - one teaspoon twice a day;
• from one to five years – one teaspoon three times a day;
• children over five years old - two teaspoons three times a day;
• adults – two tablespoons three times a day.

How to take Trimedat: before or after meals?

The medicine must be used correctly. The speed of action of the drug depends on food. If the remedy is taken before meals, it acts much faster. Taking the medication with food greatly reduces its effectiveness.

After eating, you can also drink Trimedat, but you need to wait 20 minutes. During this time, most of the food is slightly digested and passes into the duodenum. The effect of this technique will be slightly lower. Patients with gastritis in remission are prescribed to take the drug more often after meals. This reduces the likelihood of damage to the mucosa during course therapy. Food protects the walls of the stomach and prevents them from being too irritated.

What diseases does Trimedat help with?

Instructions for Trimedat for various diseases in adults:

1. To treat irritable bowel syndrome, Trimedat should be taken in the acute period, 200 mg 3 times a day for four weeks. Then, to prevent relapses and achieve stable remission at the end of 4 weeks, you should continue taking Trimedat at a dosage of 100 mg 3 times a day for 12 weeks in a row. This treatment regimen: 4 weeks of 600 mg per day + 12 weeks of 300 mg per day allows for the cure of irritable bowel syndrome in almost 100% of cases.
2. People suffering from irritable bowel syndrome in remission can undergo a course of Trimedat therapy, aimed at preventing relapses, taking 100 mg tablets three times a day for three weeks.
3. For functional disorders or diseases of the digestive tract (including cholecystitis, pancreatitis, gastritis, gastric and duodenal ulcers, GERD, etc.), Trimedat as a symptomatic drug should be taken in courses lasting 2 to 3 months for both children and adults . Moreover, courses of therapy are recommended to be repeated periodically, observing intervals of at least 3 months between them. Remember that the effect of Trimedat in chronic diseases develops and manifests itself only at the end of the second week of use, so short courses of therapy are useless in these cases.
4. When used as an emergency remedy, for example, for symptoms of dyspepsia in children (bloating, belching, nausea, cramps, intestinal colic, etc.), the drug should be given in an age-appropriate dosage for several days until the symptoms of the disorder completely go away . Likewise, adults can take Trimedat in short courses if symptoms of dyspepsia appear that are not associated with diseases or functional disorders of the gastrointestinal tract. That is, if a child or adult has bloating, nausea, colic or abdominal cramps, diarrhea not associated with an infectious disease (for example, “bear disease”), or flatulence, then to eliminate these symptoms you can take Trimedat in an age-appropriate dosage . In such cases, when symptoms of dyspepsia occur episodically and are not constantly present, the drug should be taken in short courses lasting 1 to 3 days.
5. When preparing for an X-ray or endoscopic examination of the digestive tract, take Trimedat 1-2 times in an age-appropriate dosage before the upcoming manipulation.
6. When treating postoperative paralytic ileus, Trimedat must also be taken at an age-specific dosage for at least 4 weeks. After four weeks of treatment, it is necessary to assess intestinal motility and, based on the data obtained, make a decision on stopping or continuing therapy.

IBS is most often a manifestation of neurosis

But, in the vast majority of cases, IBS is a manifestation of neurosis, to one degree or another. All functional gastrointestinal pathologies are caused by a psychosocial factor. Doctors even have an interesting specific term - “brain - gut”. Why am I dwelling on this detail in such detail? Patients often complain: they took the medicine, after half an hour they felt dizzy, felt nauseous, darkened their vision, etc. Or I drank for a week, then suddenly became ill.

People diagnosed with IBS are individuals who have a certain type of nervous system. Therefore, the overwhelming number of cases of side effects is caused by suspiciousness. In no way do I want to offend patients, since their illness, which is of a functional nature, is still an illness from which a person suffers and which, without any doubt, needs to be treated.

THE DIAGNOSIS OF “FUNCTIONAL DISORDER” CAN BE MADE ONLY AFTER ORGANIC PATHOLOGY HAS BEEN EXCLUDED!

This is why laboratory diagnostic tests are mandatory for patients.

The drug Trimedat is in a certain sense a unique remedy. Trimedat can be prescribed to patients suffering from IBS, regardless of the cause of the disease. Both with the functional nature of the disease and with organic pathologies, the remedy copes with the task perfectly. The drug quickly normalizes peristalsis and thanks to this, the main complaints, due to which the patient is unable to lead a normal life, go away.

But you shouldn’t choose the dosage and duration of the course yourself. In addition, in the vast majority of cases, the prescription of other medications is required. As we have already said, IBS is a consequence of stress, anxiety, and internal “pressure.” Therefore, such patients often require additional sedatives. It is a good idea to consult a psychologist or psychotherapist. The inclusion of Trimedat in complex therapy, especially in the presence of organic changes in the gastrointestinal tract, minimizes the occurrence of possible side effects. An undoubted advantage of the drug is the ability to adjust the dose depending on the symptoms at a given time. Since the drug has an anti-inflammatory effect, the need to prescribe active anti-inflammatory therapy is eliminated, and this is another plus in favor of prescribing this particular drug.

INDICATIONS FOR USE OF THE MEDICINE

Trimedat is a medicine against digestive disorders that cause loose stools and diarrhea, available in pharmacies over the counter.

But before you start taking it on your own against manifestations of intestinal disorders (loose stools, acute diarrhea, abdominal cramps), it is important to consult a doctor, because there are many reasons that cause such phenomena. Taking Trimedat is advisable in the following cases:

• For digestive disorders in children of non-infectious origin.
• In case of disruption of the normal functioning of the digestive tract (diarrhea, discomfort, vomiting, pain) due to gastroduodenal ailments.
• When detecting gastroesophageal reflux disorders (gastroesophageal reflux disease).
• With diagnosed irritable bowel syndrome (IBS), accompanied by constipation, vomiting, diarrhea, painful cramps and other characteristic symptoms.
• During the period of preparing the patient for hardware examinations of the digestive system (ultrasound, endoscopic and other types);
• In case of functional diarrhea.
• Can be prescribed in case of postoperative complications, in particular, intestinal obstruction caused by paralysis of the intestinal muscles.

Main settings

Irritable bowel syndrome (IBS) is a functional disease. That is, it occurs with symptoms characteristic of motor-secretory disorders in the absence of organic pathological changes in the gastrointestinal tract. It is customary to separate the types of disease, because with IBS there may be other disorders that are classified as functional, and symptoms that are a consequence of organic pathologies of the digestive organs. In each specific case, a treatment algorithm is prescribed by a gastroenterologist who conducts an external examination, listens to complaints, and the patient undergoes an examination based on a medical history.

Indications

The drug Trimedat is primarily intended to restore stable functioning of the digestive system and eliminate all negative symptoms.

Indications for use of the drug Trimedat are as follows:

• For constipation of various types. The drug stimulates the work of smooth muscles, which, in turn, accelerates the removal of waste products from the colon naturally.
• For bloating and increased gas formation.
• For functional disorders of gastric motility.
• For problems with digestion of food and absorption of nutrients.
• In case of paralytic intestinal obstruction resulting from surgical intervention.
• For pain and cramps in different parts of the abdomen, which are symptoms of irritable stomach syndrome.
• To prepare the digestive organs for examination.

So, the drug is prescribed mainly to restore gastric motility and stabilize the digestive process with the elimination of all negative symptoms.

Features of the action

Trimedat belongs to the category of antispasmodic drugs. It has a gentle effect on the intestinal contraction system.

The drug is quite safe for the body, so it can be taken for a long time

Trimebutine has the properties of a targeted effect on the smooth muscles of internal organs. Thanks to this, it has the following effect:

• stimulates muscle contraction in hypokinetic disorders;
• relieves spasms in hyperkinetic manifestations of diseases, for example, pancreatitis;
• eliminates colic and bloating;
• restores intestinal motility and eliminates constipation;
• restores normal functioning of the sphincter of Oddi;
• improves the flow of bile and digestive enzymes;
• promotes the manifestation of the correct intestinal response to undigested food;
• promotes the timely movement of food from the stomach to the intestines.

Trimedat acts on various organs of the digestive tract, thereby eliminating many unpleasant symptoms

Thanks to Trimedat, it is possible to normalize the digestive process and restore the correct chain of reactions of the gastrointestinal tract to incoming food. Unpleasant sensations, heaviness in the stomach, cramps are eliminated. In case of problems with the gallbladder and pancreas, it is possible to restore the full flow of digestive juices and enzymes into the gastrointestinal tract.

Thanks to the targeted effect of the active substance, problems of both directions are eliminated: both hyperkinetic and hypokinetic.

What does Trimedat help with? Indications for use

Most often, Trimedat tablets are used for various dyspeptic symptoms that accompany diseases of many parts of the gastrointestinal tract. These signs include:

• bloating;
• painful spasms and colic;
• increased gas formation;
• constipation and diarrhea;
• heaviness in the stomach and abdomen;
• heartburn;
• burping;
• vomiting;
• nausea;
• distension.

Often, such signs are characteristic not of organic damage to the gastrointestinal tract, but of functional disorders. In children, they can be triggered by past infections, connective tissue dysplasia, diseases of the autonomic nervous system, and neuroses. In adults, the drug effectively relieves symptoms that arise due to stress, poor diet, and bad habits.

In complex therapy, tablets are indicated in the treatment of GERD (gastroesophageal reflux disease) and esophagitis. The tablets also help prepare for intestinal examinations - irrigoscopy, colonoscopy.

Trimedat description

This medicine is a strong antispasmodic . Tremedat has fairly broad and vague indications for use. Doctors prescribe this drug if the patient has pronounced signs of peristaltic disorders:

• gagging, abdominal pain;
• IBS (abdominal pain accompanied by bloating and severe cramping);
• diarrhea;
• constipation;
• gastroesophageal reflux syndrome;
• intestinal problems after surgery;
• preparation for endoscopy;
• problems with gastrointestinal motility.

When do you take Trimedat?

This drug has two release forms. Available in dosages of 100 mg and 200 mg. The only difference is the concentration of the main substance, trimebutine, in the drug. In addition to it, the composition is also formed by silicon dioxide, lactose, starch and magnesium stearate.

Trimedat is a non-selective blocker of gastrointestinal smooth muscles ; its description suggests that it is not characterized by any specific direction and does not have one principle of action. It normalizes disrupted digestive processes, minimizes increased gastrointestinal activity and, conversely, stimulates decreased activity.

You will notice results within 30 minutes after taking these tablets. It is worth noting that this drug does not just stimulate the digestive system. It increases irritability of the rectum, relaxes the muscles of the anus and, therefore, acts as a laxative.

METHOD OF APPLICATION AND DOSAGE

The tablets are washed down with water and swallowed whole without chewing. It is better to drink water without gas, and do not replace it with tea or other hot drinks.

For adults and children over 12 years of age, when treating diarrhea caused by impaired peristalsis, a daily dose of up to 600 mg of the active component is recommended, divided into 3 doses. The treatment course lasts until a stable effect is achieved.

After completing a course of treatment for IBS, which was accompanied by diarrhea, intestinal colic, and stomach pain, a prophylactic course is prescribed to prevent relapse. The daily dose in this case is 300 mg of trimebutine. The duration of therapy can vary from three to four months.

Whether to take the medicine before or after meals depends on the purpose for which it is done. During the course of treatment, it is optimal to take the drug a quarter of an hour before meals. When this is not possible, it is acceptable to take the tablet within half an hour after eating. If spastic pain occurs suddenly, then you are allowed to take the pill immediately to reduce pain.

While taking medication as a remedy for IBS, it is advisable to consult a doctor about prescribing an appropriate diet.

TRIMEDATE FOR CONSTIPATION

IBS can manifest itself not only with diarrhea, but also with the opposite phenomenon - constipation. In this case, complex treatment is prescribed, which includes:

• Strict diet.
• Taking medications to normalize intestinal microflora.
• Taking Trimedat, aimed at restoring normal intestinal motility. For this, adults are prescribed one tablet with a dose of 200 mg three times a day, half an hour before meals. The duration of therapy is up to one month. This is followed by a course of maintenance therapy, which involves taking 100 mg (half a tablet or a tablet with a lower dosage) of trimebutine with the same frequency for three months.

USE IN CHILDREN

The following rules must be followed:

• For children under three years of age, the drug against diarrhea and other manifestations of digestive disorders is not prescribed.
• For patients aged 3 to 5 years, a daily dose of 75 mg of the active substance in three doses (a quarter of a 100 mg tablet at a time) is indicated.
• For children aged 5 to 12 years, when loose stools or diarrhea appear, 50 mg is prescribed at each dose. The daily norm is 150 mg.
• Patients over 12 years of age take the standard adult dosage.

PREGNANCY AND BREASTFEEDING

There is no information confirmed by clinical studies on the safety of use in the first trimester of pregnancy. But during experimental studies, no data were recorded on the effect of Trimedat on the occurrence of congenital deformities and fetal anomalies. Therefore, the described drug is usually not prescribed to women in the first months of pregnancy and while feeding the baby with breast milk. The decision on the advisability of taking Trimedat to treat the causes of loose stools and diarrhea is determined by the doctor.

Dosage and rules of administration

Trimedat is available in the form of tablets with different dosages of the active substance. They should be taken in combination with other medications to provide a comprehensive effect on the problem, especially with pancreatitis. The exact program and dosage is determined by the doctor.

In general, the following standards have been adopted for maximum daily doses:

• 75 mg for children 3 - 5 years old;
• 150 mg for children 6 - 12 years old;
• 300 - 600 mg for adults and children over 12 years of age.

It is extremely undesirable to allow an overdose, but there are no special instructions in the instructions on this matter.

Trimedat should be taken 3 times a day before meals. The tablets are not chewed and washed down with water. They begin to act after half an hour. For irritable bowel syndrome, the maximum dosage is 600 mg.

To maintain normal functioning of the gastrointestinal tract after completing the main course of treatment, maintenance therapy may be prescribed. Its essence is to take half the dose for 4 to 12 weeks, depending on the recommendations of the attending physician and the diagnosis.

CONTRAINDICATIONS FOR USE

The drug is contraindicated for use against diarrhea and loose stools in the following conditions:

• The first four months of gestation and the period of breastfeeding.
• Children under three years of age.
• When identifying individual sensitivity to trimebutine.
• Lactase deficiency or galactose intolerance, since lactose is one of the auxiliary components of the drug.

Taking an increased dose of Trimedat against diarrhea or loose stools leads to increased possible side effects. Treatment in this case is symptomatic, aimed at relieving acute manifestations. There is currently no specific antidote.

Use during pregnancy and lactation

Pregnancy and lactation are the times when a woman should avoid using any medications as much as possible. The effect of the drug Trimedat in relation to fetal development is poorly understood, and therefore, in the first months of pregnancy, for the safety of mother and child, experts do not recommend using this drug.

In some cases, taking the drug after 13-14 weeks of pregnancy is prescribed for exceptional indications and the impossibility of replacing it with other drugs. Strictly monitoring the readings of biochemical blood tests and urine tests.

During lactation, all medications used to relieve painful symptoms by the mother are released in varying degrees of concentration into breast milk for feeding the baby. Since Trimedat is contraindicated in the recommendations of pharmacologists for children under 3 years of age, it should not be taken while the child is breastfeeding.

It is prohibited to take the drug while breastfeeding

In an acute situation and the need for admission, the child is weaned and temporarily transferred to artificial nutrition. Mothers are recommended to express breast milk throughout the entire period of treatment to maintain lactation. After complete completion of the dose (after 2-3 days), breastfeeding is resumed.

Characteristics of the drug

Trimedat can be purchased at pharmacies in tablet form (100 mg, 200 mg, 300 mg). The drug with a dosage of 300 mg has a prolonged effect, so it is used for severe pain. The active component of Trimedat is trimebutine maleate. The product helps normalize the peristalsis of the intestinal tube. The action of the drug occurs by stimulating β-μ-, k-receptors, as well as receptors of the intestinal wall. The medicine has no central effect.

Indications for use of Trimedat:

• increased gas formation in the intestinal tube, pain in the abdomen;
• change in the nature of stool, decrease or increase in the urge to defecate;
• irritable bowel syndrome;
• functional diseases of the digestive tract (reflux esophagitis, gallbladder dysfunction, pathology of the sphincter of Oddi);
• intestinal obstruction after surgical treatment;
• preparatory measures for ultrasound and x-ray examination of the intestine.

Do not use the medicine if you are allergic to its components. The drug is not prescribed to pregnant and lactating patients. In pediatric practice, the dosage is selected individually according to the age group.

Undesirable manifestations of the drug:

• fatigue, fatigue;
• vestibular disorders;
• headache;
• rash of allergic origin;
• loose stools or constipation;
• dyspeptic manifestations;
• menstrual irregularities in women;
• increase in size of the mammary glands;
• decrease in urine volume.

Interaction with other drugs

Like all medications for children and adults that affect the intestinal flora, Trimedat, according to the instructions for use, is an active substance that affects the functioning of the entire gastrointestinal tract.

Experts advise that drugs of this type should not be taken simultaneously with other medications. Due to the therapeutic orientation of Trimedat, their beneficial effect on the entire body may be reduced.

It is not recommended to use the drug with other medications

As a result of scientific developments, it was discovered that the drug reacted with the pharmacological group, which includes Zotepin. When several drugs are used together, the anticholinergic effect increases. The enhanced effect of d-tuboruratin on the body has also been scientifically confirmed.

Analogs

Analogues of the drug are classified by their similarity to the active components and the provision of the required therapeutic effect. Based on the main substance, trimebutine maleate is isolated. Based on their medicinal effect, the following drugs are distinguished:

• Irmalax (enriched with vitamin C);
• Bactistatin;
• Halidor;
• Spasmonet;
• Mucofalk;
• No-shpa or Drotaverine;
• Spakovin.

In childhood, it is very important to use the original drug and not its analogue. It is unacceptable to switch from taking one drug to another on your own, even if it is much cheaper

For all questions about alternative therapy, you should contact a gastroenterologist.

When to stop taking the drug

Trimedat has negative reviews for constipation in adults in cases where it is taken despite existing contraindications. These laxatives should not be used to treat intestinal dysfunction caused by acute liver failure, as well as during exacerbation of pancreatitis.

It is forbidden to resort to this type of laxative for rectal bleeding and intestinal obstruction. Therefore, if constipation is accompanied by severe pain and deterioration in general health, you should consult a doctor.

In addition, the drug is not recommended for use if you have individual intolerance or hypersensitivity to certain components. Constipation cannot be treated with Trimedat during pregnancy and breastfeeding. Also contraindicated for use is children under three years of age.

Consequences

Side effects of the drug are caused either by exceeding the dosage (not reflected in the statistical data of clinical trials of the drug) or by the body’s reaction to the active substance. Side effects may include the following:

• increased dryness of the mucous membranes of the pharynx;
• unpleasant taste;
• constipation along with diarrhea;
• fatigue and drowsiness;
• the appearance of a rash on the skin;
• uremic signs and urinary retention;
• menstrual irregularities in women (especially young girls);
• enlargement of the mammary glands and pain in the breast area;
• dizziness.

It is possible to find out the true cause of the development of side effects and differentiate them from diseases of internal organs only after a diagnostic examination. If there is a relationship between taking Trimedat and discomfort, you should consult your doctor to change the dosage or choose alternative methods of treatment.

Dosage regimen

It is recommended to take Trimedat tablets half an hour before eating, do not chew the drug, and wash it down with plenty of clean still water.

In cases where this method of administration causes nausea, it is recommended to take Trimedat after eating food, no earlier than 30-35 minutes later.

• Adults are recommended to take one tablet 3 times a day, the duration of treatment is up to 21 days.
• For ages 3 to 5 years, the drug is prescribed as a quarter of a tablet three times a day for a duration of treatment of no more than 5 days.
• For children under 12 years of age, take half a tablet three times a day for no more than 7 days.
• For acute diseases, an increased dosage of Trimedat can be used, up to 6 tablets per day, under the supervision of the attending physician.

The duration of treatment is determined individually and should not exceed 30 days.

ANALOGUES

Neobutin is an absolute analogue of Trimedat. It contains the same active and auxiliary substances. Available in tablets with the same dosage as Trimedat, packaged in blisters of 10, 15, 20 and 30 units each. The cost of 30 tablets with a dose of 200 mg ranges from 350 to 500 rubles.

In terms of therapeutic effect, cheaper drugs are similar: No-shpa (drotaverine), Papazol, Papaverine. And also Betamax, Irmalaks, Spakovin. They relieve spasms that cause diarrhea and intestinal pain. Those who do not trust traditional medicine can try using the homeopathic antispasmodic Iberogast.

DUSPATALIN OR TRIMEDATE WHAT IS BETTER?

These two drugs have similar effects on intestinal smooth muscle. They contain different active ingredients, therefore, when treating the causes of diarrhea, one drug can be replaced with another if there is a high sensitivity to one of the components. But it is important to note that the spectrum of action of Trimedat is somewhat wider; it affects the entire intestine, while Duspatalin actively works only in the colon. When answering the question, Duspatalin or Trimedat, which is better, it is important to take into account the individual qualities of your own body. Sometimes doctors prescribe these medications to relieve diarrhea to choose from, asking the patient to try both medications and evaluate the result

Sometimes doctors prescribe these medications to relieve diarrhea as a choice, asking the patient to try both medications and evaluate the result.

Contraindications and restrictions

Like other medications, this drug has contraindications. Trimedat is not recommended for use in the following cases:

1. intolerance to the components of the product;
2. pregnancy in the first trimester;
3. breastfeeding period;
4. individual contraindications.

The drug contains lactose, so it is not suitable for people with lactase deficiency

You also need to pay attention to other excipients, as they can cause allergies.

Trimedat can provoke an allergic reaction or cause an exacerbation of existing allergic diseases

Sensitivity to this medicine may manifest itself in the form of redness of the skin and rashes on the body, itching. Patients with chronic urticaria are especially prone to this reaction.

In case of severe attacks, it is better to stop taking the medicine for a while. In any case, treatment should be supervised by a qualified physician.

As for the pregnancy period, in some cases it is allowed to use Trimedat in short courses. It does not have a toxic effect on the fetus, but is able to penetrate the placental barrier, and due to the lack of information on the effect on the development of the child, it is better not to use the drug unless absolutely necessary.

For the treatment of children, it is allowed to use products with trimebutine, but before reaching the age of three, tablets are prohibited; other forms of medication must be used. If there is no effect or suspicious symptoms appear, use of the drug is discontinued.

The dosage of Trimedat for children is two times lower than for adults

Side effects

Due to the small amount of auxiliary ingredients, Trimedat rarely provokes the development of allergic reactions. Sometimes there are cases of the following negative manifestations:

• decreased hearing acuity;
• headache;
• weakness, apathy, fatigue;
• rashes and redness on the skin;
• change in taste sensations;
• emotional instability;
• drowsiness.

Side effects of Trimedat also include menstrual irregularities, in which the mammary glands increase in size and painful sensations appear when walking or touching.

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Author of the article: Sheveleva Lyudmila Gennadievna

Side effects

Trimedat, when following the instructions for use for children and adults, is well tolerated by patients. During treatment, the presence of mildly expressed negative reactions of the body was extremely rarely noted.

Conditions that can provoke any of the components of the drug into individual intolerance in patients during its use:

• Weakness and dizziness that occurred after taking it.
• Changes in taste sensations in the oral cavity.
• The urge to vomit and nausea that appeared after taking the medicine.
• Feeling of dry mouth.
• Allergic manifestations in the form of small skin rashes such as urticaria, in severe cases of individual intolerance to the components of the drug - Quincke's edema.
• Diarrhea or constipation.

• Manifestations of increased fatigue.
• Changes in behavior (restlessness, hearing loss).
• In the female genital area, changes in the menstrual cycle, painful swelling in the mammary glands.

It should be noted that the warning about the manifestation of the above reactions is for informational purposes only for patients prone to allergic reactions to all medications contained in Trimedat.

Directions for use and doses

It is recommended to take Trimedat a few minutes before meals for both adults and children. You can do it after eating, but after 30 minutes.

If any negative symptoms appear after eating, such as cramping or pain, it is recommended to take the drug immediately.

For adults

In order to get maximum effectiveness from treatment, it is recommended to take Trimedat before meals in an amount of 50 to 200 mg three times a day.

It is better to consult a doctor who will make the correct diagnosis, select the optimal dose and duration of treatment.

There are general recommendations:

• For irritable bowel syndrome, it is recommended to take the drug for a whole month, 200 mg three times a day.
• For prevention, reduce the dose to 100 mg three times a day for two weeks.
• Before preparing for a study of the digestive system, it is recommended to follow the age-specific dose and take the drug one to two times a day.
• It is recommended to take the drug for one month after surgical treatment of intestinal obstruction.

Only a specialist can correctly calculate the optimal dose, taking into account the condition of a particular patient.

For children

• The drug can be taken after 3 years, but only after consulting a doctor.
• Children over 3 years old can take 25 mg three times a day.
• Children over 6 years old are prescribed 50 mg three times a day.
• After 12 years, you can take an adult dose, namely from 100 to 200 mg at a time.

It is recommended to start with a minimum dose in order to identify side effects in time and stop treatment.

Use during pregnancy and breastfeeding

According to the manufacturer, no studies or experiments have been conducted on pregnant women, so it is impossible to say with confidence about the absolute safety of the drug. In addition, the active substance is absorbed into the blood and has the ability to penetrate to the fetus through the placenta. Therefore, it is recommended to take Trimedat during pregnancy only in the absence of contraindications and after consulting a doctor. You need to be especially careful in the early stages of pregnancy, when the formation of important fetal organs is observed.

Experts do not recommend taking the drug while breastfeeding, because the main components can enter the baby’s body through breast milk. In this case, it is better to choose another drug that is not absorbed into the blood.

Trimedat for stomach pain

The active ingredient of the medicine is trimebutine (maleate) 100 (200) mg per tablet. It began to be used in various dosage forms more than 50 years ago for abdominal pain and digestive disorders. Additionally, the tablet preparation includes magnesium stearate, lactose, corn starch, talc, colloidal silicon dioxide. The medicine is available without a prescription.

The drug begins to act on the gastrointestinal tract 1.5 hours after taking the tablet (duration of action - 5 hours). It is believed that for an effective systemic effect on the entire digestive system, it should be taken three times during the day. After administration, trimebutine begins to normalize the contractility of the stomach muscles, affecting the layers of the epithelium.

The speed at which food bolus leaves the stomach is optimized. The pressure of the esophageal sphincter on the stomach is normalized, which prevents the backflow (reflux) of food and acid into the esophagus, leading to vomiting, heartburn, and nausea. This ensures relief of stomach pain.

Trimebutine restores and stabilizes the lost physiological activity of the intestinal muscles (peristalsis), which is often the cause of ailments of the digestive system.

The drug Trimedat begins to act on the gastrointestinal tract 1.5 hours after taking the tablet

"Trimedat" evens out and coordinates the intensity of muscle contractions and movements of all parts of the long intestine. Food begins to move through it at a speed optimal for the body.

As a result, daily bowel movements are carried out more naturally and easily, and the response of the colon to food irritants is optimized. The biological availability of the active substance does not exceed 6%. It accumulates and decomposes in the liver, and is excreted in the urine (about 70% in the first day).

The drug "Trimedat" is prescribed to adults and children. The dosage should correspond to the age category of the patient.

The following dosages have been established:

• people aged 12 years and older - one tablet containing 100 (200) mg of trimebutine (depending on the condition) three times a day;
• children from 5 to 12 years old - 50 mg (1/2 tablet of the minimum dosage) three times a day;
• for children from 3 to 5 years old - 25 mg (1/4 tablet of the minimum dosage) in three doses during the day.

Taking Trimedat 0.5 hours before meals prepares the digestive system for the passage of food.
The duration of the course is set depending on the patient’s condition and the characteristics of the course of the disease (the standard dosage may be reduced).

How to take Trimedat for stomach pain

Taking Trimedat 0.5 hours before meals prepares the digestive system for the passage of food. The tablet (part) is not chewed and washed down with 150 ml of warm water. The pain syndrome is relieved by taking the drug after eating (within 20 minutes).

When an exacerbation occurs, the maximum dose can be up to 600 mg per day (three 200 mg tablets). It is observed for 4 weeks. Subsequently, treatment continues for a 12-week course with a daily dose of the drug of 300 mg, which ensures the suppression of possible relapses.

Taking pills should always be accompanied by a diet (boiled, steamed and oven-baked food, fatty, spicy, floury, fresh fruits and vegetables are excluded). Long-term (many years) use of the medication is carried out in cycles. They take breaks of 2-3 months duration.

Side effects of the drug Trimedat

The drug has no identified side effects:

Side effects of Trimedat are largely caused by individual intolerance to the components of the drug

• the appearance of unmotivated anxiety;
• decreased hearing sensitivity;
• irregularities in the menstrual cycle;
• skin allergic manifestations of varying strength.

Such manifestations are largely caused by individual intolerance to the components of the drug.

Contraindications for use apply to patients under 3 years of age and those who have been diagnosed with allergies (allergic reactions to the components of the medication are likely). It is strictly undesirable to prescribe the drug in the 1st third of the child's gestation period and during breastfeeding.

There are drugs on sale that are similar to Trimedat in terms of the active substance (trimebutine maleate) or have similar pharmacological effects. However, replacement should be agreed with your doctor, since medications may contain components that the body will not accept.

Instructions for use

The dosage of the drug for children is indicated by the manufacturer. Children from 3 to 5 years old need to take 25 mg of the drug per day, from 5 to 12 years old - 50 mg three times a day. Children over 12 years of age receive an adult dose of 100–200 mg of the drug daily.

Since the drug is produced with a minimum content of the main component of 100 mg, a quarter or half of a tablet must be used for a child. If only 200 mg tablets are available, you need to divide it into 8 and 4 parts, respectively.

If a small child does not know how to swallow tablets, the required part can be crushed into powder using a regular teaspoon, and then add a little water to form a suspension. You can also add the crushed tablet to a drink or sweet jam, which will be similar to syrup.

The medicine should be given 30 minutes before or 20 minutes after meals. The course of treatment can be either one-time or long-term – up to several months.

There are no cases of overdose recorded in the medical literature. If parents are sure that the child has taken a large amount of medicine, it is necessary to seek medical help, and in the meantime, perform gastric lavage with a weak solution of potassium permanganate. Then the child should be given an absorbent, for example, Smecta, and monitor his health for 24 hours. If symptoms such as constipation or diarrhea occur, apply symptomatic treatment.

Should I take Trimedat for hemorrhoids?

Trimedat is actively used in the complex treatment of hemorrhoidal disease. Timely treatment is especially important in the presence of constipation - this is one of the important risk factors for the development of hemorrhoids. If there is no bowel movement for more than two days, it is necessary to take measures to normalize intestinal functions, since constipation leads to an increase in existing hemorrhoids and the formation of new ones. Therefore, in the chronic form of hemorrhoids, Trimedat is prescribed to eliminate the feeling of heaviness in the anus, which precedes an exacerbation of the pathology.

During the period of exacerbation of hemorrhoidal disease, Trimedat eliminates pain and spasms in the rectum, to prevent strangulation of pathologically enlarged venous cones and the development of rectal bleeding. Taking Trimedat during this period normalizes stool, eliminating constipation, thereby facilitating bowel movements. After removal of hemorrhoids, the drug accelerates epithelization of the mucosa.

For the treatment of hemorrhoids, the medicine is prescribed by the doctor individually, taking into account the severity of the nodes, clinical manifestations, and the patient’s age. Typically, the dose of the drug corresponds to the standard treatment regimen - 200 mg × 3 times a day. Duration of use - until stool normalizes, pain disappears, and nodes decrease. Therapy is supervised by a gastroenterologist or proctologist.

FORM OF RELEASE AND COMPOSITION OF THE MEDICINE

Trimedat is a drug originally from Korea, produced by Dae Han New Pharm Co. The medicine is classified as an antispasmodic. It regulates intestinal motor function, helping to stop diarrhea or eliminating constipation, which are caused by insufficient (excessive) peristalsis.

Produced only in tablet form. The tablets are round, flat, white. Each contains 100 or 200 mg of the active ingredient trimebutine. In addition to it, the composition contains additional components.

• Tablets containing trimebutine 100 mg. The TM symbol and six triangles are pressed onto the surface of each: three below and above it. A pair of crossed stripes are pressed onto the reverse side.
• Tablets containing trimebutine 200 mg. On the surface of each there are two figures, similar to drops, pressed. On the reverse side there is one stripe.

The manufacturer packages tablets with both dosages in foil and film blister packs of 10 units each. Packages of 1-3 pieces are placed in cardboard boxes, they are accompanied by instructions for use, which provide complete information about why the medicine is prescribed and how to use it.

Composition of the drug

Instructions for use for children (there are age restrictions) and adults are required to be studied. Trimedat is a drug used to treat a wide range of diseases of the gastrointestinal tract. Trimebutine maleate is present in the composition as the main medicinal component.

Components such as silicon, magnesium, pharmacological talc, corn starch and povidone are included in the form of auxiliary components.

Use in childhood

In order not to be mistaken about the possibility of using a medicine in childhood, it is important to carefully read the information about the country of the manufacturer:

• Trimedat, manufactured in Korea, is not recommended for use by persons under 12 years of age.
• The domestically produced drug is contraindicated in children under 3 years of age. But this point requires detailed consideration, since in practice parents are often faced with the prescription of the drug at an earlier age.

Trimebutine, which is included in the composition, is safe for use in infancy. But since its dosage form is tablets, it physically cannot be taken by a small child. That is, the contraindication relates specifically to the release form, and not to the active compound.

Therefore, pediatricians and gastroenterologists advise crushing the tablet and adding a small amount of water. And give the already obtained suspension to the baby. The dose and how to properly dilute the drug (how many ml of liquid to add) should be calculated by the doctor, as this will depend on age and weight.

Most often, for children from six months of age, Trimedat is prescribed to eliminate the difficulty of emptying the large intestine (constipation) during the introduction of complementary foods (0.5-1 teaspoon 2-3 times a day).

Use for constipation

Trimedat is taken strictly according to the instructions for use. For children, the doctor selects an individual dose. It depends on how old the child is (the drug is approved for use after 3 years of age), the duration of stool retention, the prerequisites for the observed complication of the stomach and intestines, and the child’s weight.

After completing the full course of treatment, following all the doctor’s recommendations and adjusting your diet, you can completely eliminate the problem of constipation.

When stool is retained for several days, an inflammatory process begins to develop in the intestines. This problem can become chronic, significantly complicating the quality of life.

Since the intestines have an impact on all functions of the body, constipation is manifested not only by painful sensations in the abdomen, but also by increased nervous excitability, insomnia, bloating, belching, and exacerbation of hemorrhoids.

Unlike laxatives, which lead only to a one-time elimination of this problem and cause the intestines to become accustomed to artificially induced bowel movements, the drug Trimedat is the basis of a comprehensive treatment to eliminate constipation.

According to its structural composition, it has the ability, at the level of high-molecular compounds with amino acid particles found in the intestines, to promote the complete restoration of motility and the relief of muscle spasms throughout the gastrointestinal tract.

Contraindications

Contraindications for Trimedat are few compared to its analogues. The pharmacological drug should not be taken by patients with individual intolerance to the active substance or auxiliary ingredients. The drug Trimedat for children can only be used when they reach 3 years of age

Patients with diagnosed renal or hepatic insufficiency should take the drug with caution and under medical supervision

Trimedat is not used during pregnancy; taking tablets of any dosage in the first trimester of pregnancy is strictly prohibited. Tests on the safety of the medicine for the health of the expectant mother and baby have not been carried out. There is also no evidence base for the safety of using Trimedat during breastfeeding.

Terms of sale and storage

Trimedat is an over-the-counter drug.
The shelf life of the tablets is 3 years. In this case, storage conditions must be observed: do not leave the drug exposed to direct sunlight, high or low temperatures. This may reduce the effectiveness of the medicine. The optimal temperature for storage is room temperature. It is also important to ensure that the storage location is inaccessible to children.

For gastrointestinal disorders, as well as pancreatitis, Trimedat is often used. This drug is very effective and quite safe to use, and therefore is popular among both doctors and patients.

Trimedat will help patients with pancreatitis get rid of dyspeptic symptoms

Indications

"Trimedat" is prescribed for intestinal problems of various origins, including abdominal pain, vomiting, diarrhea, and constipation. The medicine is used to relieve symptoms and treat dyspeptic intestinal disorders, for example, early satiety, a feeling of fullness.

Trimedat Valenta, produced by a Russian pharmaceutical company, is recommended for children aged three years and older. However, as prescribed by a pediatrician or gastroenterologist, the medicine can be used earlier, for example, from 2 years of age.

Independent use of Trimedat in children under three years of age is not recommended, since the effect of the drug on children in this age group has not been studied in clinical settings. At the same time, the metabolism of young children differs from that of adults and older children.

Contraindications of the drug

The dosage form has several contraindications for use.
And when prescribing it to patients, they should be taken into account, otherwise the patient’s condition may only worsen. Contraindications :

1. Pills are not prescribed to children who are not yet three years old. This also applies to children's drugs with small dosages of the active substance.
2. Trimedat 200 milligrams should not be used by children under 12 years of age.
3. It is not recommended to use the tablets for people who have allergic reactions to any component of the drug.
4. The dosage form is contraindicated for pregnant women during short periods of up to fourteen weeks of pregnancy.
5. Patients with lactose deficiency or lactose intolerance or with glucose-galactose malabsorption should not take Trimedat.

Do not exceed the dosage of the drug to avoid side effects.

What happens if you drink alcohol while being treated with Trimedat: the most common consequences

When taking Trimedat you should follow a diet.
You cannot eat fatty, salty, canned, fried foods, fast foods, carbonated drinks, and baked goods. It is also worth temporarily giving up vegetables and fruits. After treatment, they gradually return to a normal diet. Alcohol and medication that modulates intestinal motility cannot be combined together. Drinking small amounts of alcohol is permitted, provided certain conditions are met.

Immediately after drinking alcohol, taking medication with trimebutine is contraindicated. This is due to the fact that the therapeutic effect of the base substance of the drug will be neutralized by the irritating effect of alcohol on the mucous membrane of the hollow structures of the digestive tract.

In order to obtain the desired result, a combination of medications is allowed if the following conditions are met:

1. A small amount of alcohol consumed.
2. More than an hour has passed since the last drink, enough for it to be completely absorbed into the blood.

The primary consequence of simultaneous use of alcohol-containing drinks and medication is a decrease in therapeutic effect. With repeated combinations, a systematic disturbance of the peristalsis of the hollow structures of the gastrointestinal tract occurs in the future with the appearance of the following signs of a violation of the functional state of the digestive system:

1. Periodic bloating (flatulence).
2. Heartburn, which is a consequence of the backflow of stomach contents into the esophagus.
3. Unstable stool, characterized by a tendency to constipation.

Against the background of a weakening of the pharmacological effect of the drug, the intensity of the signs of the disease increases, which has become a medical indication for the prescription of Trimedat.

Substitutes for therapeutic effects

Substitutes include those medications that have different active ingredients from Trimedat, but the same therapeutic direction and identical purposes. Such analogues are prescribed to those patients who are intolerant to trimebutine. The effectiveness of therapeutic analogs is as high as that of Trimedat.

Duspatalin

Duspatalin stops the penetration of calcium molecules into the smooth muscle fibers of the organs of the entire digestive system. Duspatalin reduces the calcium level in cell membranes, stops the interaction with protein compounds, which helps relax the muscle tissue of the smooth muscles of the organs.

Mechanism of action of Duspatalin

The main component relieves the tone of the sphincter of the biliary organ, which helps to enhance the process of processing food entering the stomach. The active ingredient in Duspatalin is mebeverine.

The drug is prescribed for:

• abdominal pain and cramps;
• disorders in the biliary tract;
• cholecystitis and cholestasis;
• IBS;
• non-infectious colic origin.

An antispasmodic is not prescribed to patients for the following reasons:

• allergy to a drug;
• age up to 10 years;
• pregnancy in the 1st trimester;
• lactation period.

https://youtube.com/watch?v=2Jsb7H1TGVA

There is no information from clinical studies on the safety of using the drug during pregnancy. In this regard, in the 1st trimester, taking the medication is strictly prohibited, and in the 2nd-3rd trimester, taking the medication only for vital signs and under medical supervision. If there is a need to take Duspatalin during the lactation period, then you need to transfer the child to artificial nutrition.

Patients over 10 years of age should take 1 capsule of Duspatalin twice a day. The duration of therapy is set by the doctor personally in accordance with the pathology and the degree of its progression. Also, if necessary, the doctor can prescribe a personal treatment regimen and set other dosages.

Adverse reactions include the following symptoms:

• allergies - rashes, urticaria, hyperemia and itching of the skin;
• anaphylactic shock;
• deviations in the gastrointestinal tract - constipation, diarrhea, dyspepsia, nausea, which can provoke vomiting, diarrhea and pain in the epigastric region;
• body fatigue, headache, sleep disturbance, irritability and nervousness and dizziness.

Iberogast

Iberogast is a herbal medicine that can normalize the entire digestive process. The herbal medicine eliminates the following painful and unpleasant symptoms of digestive disorders:

• eliminates cramps and flatulence;
• normalizes gastrointestinal motility;
• reduces the feeling of a full stomach;
• reduces the incidence of constipation and diarrhea;
• reduces the acidity of gastric juice;
• fights 6 types of pathogenic intestinal microorganisms.

Iberogast is prepared in drops. Before use, the bottle with drops must be shaken well so that the sediment in the medicine disappears and the liquid becomes homogeneous.

Efficacy of Iberogast

The herbal medicine is prescribed for various diseases and disorders of the gastrointestinal tract:

• dysfunction of peristalsis;
• irritable bowel;
• pain in the gastrointestinal tract;
• discomfort in the gastrointestinal tract;
• stomach cramps;
• as part of the combined treatment of ulcerative lesions in the gastrointestinal tract;
• intoxication of the body, which is manifested by flatulence, bloating, strong and smelly belching.

The drug should not be prescribed for allergic reactions to its constituent components, and should not be prescribed with restrictions for brain injuries, pathologies of the liver and kidneys, and alcoholism

The drug is prescribed with caution to pregnant women, as well as women who are breastfeeding a newborn.

Iberogast can be used from the first days of life. You need to drink the medicine three times a day and wash it down with a small amount of water. The only condition for taking the medication is the same time interval between administration procedures.

The dosage is prescribed according to age:

• 0-3 months –5-6 drops;
• 3 months-3 years – 8 drops;
• 3-6 years – 10-11 drops;
• up to 12 years – 15 drops.

After 12 years, adult dosages of 20 drops three times a day are prescribed.

Features of Trimetad

The action of Trimetad is similar to the natural processes of excitation and inhibition of peristalsis, due to which food moves through the gastrointestinal tract.

The medication regulates the ongoing processes - when the muscle tone of the digestive organs decreases, the drug increases it, and vice versa, with increased tone, it has an antispasmodic effect, reducing it.

The main pharmacological effect is achieved thanks to the main active ingredient of the drug, which affects the enkephalenergic system of the gastrointestinal tract, thereby activating motility and normalizing digestive function.

The action of the drug is aimed at eliminating discomfort and pain in the abdominal area, eliminating flatulence and restoring the functioning of the digestive organs.

Trimedat is prescribed to regulate the motor function of the gastrointestinal tract

After administration, the drug is quickly absorbed from the intestines into the bloodstream and distributes evenly throughout the tissue structures of the body. The maximum concentration of the drug in the blood is observed 1.5 - 2 hours after administration.

To achieve positive dynamics in some diseases of the gastrointestinal tract, a fairly long period of medication is required, on average up to 1 month; if necessary, the course of treatment is increased. After which the dosage is reduced and the medication is taken for the purpose of prevention for another one to two months.

The drug is not recommended for use in pregnant women and in the postpartum period while breastfeeding.

Despite the fact that the drug is available without a prescription, you should initially undergo examination by a gastroenterologist, who will determine the most effective dosage and duration of treatment individually in each case.

Active ingredients of the drug

The main active substance is trimebutine, which is contained in one tablet in dosages of 100 and 200 mg.

Trimebutine - structural formula of the active substance of the drug Trimedat

Auxiliary components include talc, magnesium salt and stearic acid, lactose, corn starch, pyrogenic silicon dioxide.

Medical indications for appointment

Trimetad is prescribed for pathological processes in the digestive organs, accompanied by impaired peristalsis, in particular GERD (gastroesophageal reflux disease), dyspeptic syndrome, chronic abdominal pain, flatulence and disruption of normal intestinal function.

The drug is prescribed to patients with the development of late intestinal obstruction, as well as before endoscopic and x-ray examinations.

In children over 3 years of age, Trimetad is used for disorders of the gastrointestinal tract, difficult and painful digestion.

Combined use of Trimetad and alcoholic beverages

Trimetad and alcohol are substances that are completely incompatible with each other. First of all, this relates to the negative effect on the liver, which takes on the heaviest load - processing the drug and breaking down ethyl alcohol.

Alcohol compatibility

An analysis of what will happen if you drink alcohol and Trimedat follows from the composition of the medicine and the interaction of its components with ethyl alcohol. The therapeutic effect of the drug is determined by trimebutine maleate.

Liver: combination features

The main substance of the drug is converted into metabolites. The transformation occurs in the liver, which experiences increased stress. If you take Trimedat and drink alcohol, the liver will be subject to significant overload, since it needs to process both the drug and ethyl alcohol.

Important! In addition to the load on the liver, alcohol affects the effectiveness of medications that are taken simultaneously with it.

Effects of alcohol on the intestines

Trimebutine has a gentle effect on the intestines, which cannot be said about ethanol, which has an irritating effect by stimulating peristalsis. If alcohol consumption occurs frequently, irritable bowel syndrome may be triggered. The same diagnosis is an indication for the prescription of Trimedat. Accordingly, their combination will not lead to a positive therapeutic effect.

The diuretic effect of alcohol and medication: the danger of combination

Ethanol has a diuretic effect, which also extends to metabolites formed during the transformation of the active component Trimedat. If you drink alcohol together with Trimedat, the concentration of trimebutine will be reduced. In this case, the effect of treatment will not be sufficient - the medicine will be eliminated from the body faster.

The effect of alcohol on blood vessels

The presence of both ethanol and trimebutine in the circulatory system creates a load on the vessels, increasing blood viscosity. This, in turn, can provoke the development of serious vascular and cardiac disorders:

• thrombosis of various localizations;
• atherosclerosis;
• thrombophlebitis, etc.

Danger of allergic manifestations

The influence of alcohol during treatment with Trimedat is not limited only to the digestive system and blood vessels. Simultaneous presence in the body can also provoke the development of allergies.

Is Trimedat an antibiotic?

Trimedat is prescribed by doctors for inflammatory diseases of the digestive system (gastritis, enterocolitis, paraproctitis), but it does not have antibiotic properties. The drug does not have the necessary methods of influencing the microbial cell. Antibacterial agents can stop the development or kill pathogenic organisms.

With prolonged use they cause resistance (resistance or addiction). Therefore, the course of antibiotic treatment is always limited to 7-10 days. Trimedat is allowed to be taken for a long time if it does not stimulate negative consequences.

Restoring food transport helps correct the imbalanced balance of beneficial bacteria in the large intestine. therefore, indirectly, the drug prevents dysbiosis and creates favorable conditions for the spread of the necessary flora.

Pharmacodynamics

The substance trimebutine acts on calcium channels. Reduced calcium influx weakens membrane depolarization and reduces colonic motility.

As an opioid receptor agonist, trimebutine modulates gastrointestinal motility in both directions.

The effect of the drug in clinical doses on the autonomic functions of the heart with heart rate variability was studied.

Continuous electrocardiographic recordings were obtained before and after drug administration in three conditions: at rest, during controlled breathing, and during exercise. Analysis of heart rate variability showed that in all cases there was no significant difference between the administration of placebo or Trimebutin.

Scientists came to the conclusion that the drug in clinical doses does not have a significant effect on the autonomic functions of the heart.

The free low molecular weight form or salt of trimebutine quickly enters the bloodstream. Peak plasma concentrations are achieved 1 hour after administration. The time to reach maximum concentration after a single oral dose of 200 mg is 40 minutes.

Mechanism of action

The medication is aimed at normalizing peristalsis. Thanks to this, food moves evenly through the intestines. The drug allows you to completely eliminate the symptoms that accompany diseases of the digestive organ and intestinal tract. The medication is also used in a complex of symptomatic therapy.

The drug is also used as an antispasmodic. The medication reduces tension and relieves excessive tone of intestinal smooth muscles. Thanks to this, spastic pain is relieved. The medicine removes signs of intestinal dyspepsia. The medication normalizes motility and the rate of emptying is restored. The drug has many analogues, but you can change the prescription only after consulting a doctor.

The appropriate dosage of the drug will be prescribed by the attending physician.

Trimedat contains trimebutine, which has the following effects on the functioning of the digestive system:

• The active elements, entering the stomach, stimulate the smooth muscles of the intestine, which, in turn, quickly digests food, absorbs nutrients and removes waste products naturally.
• If there are problems with stool in the form of diarrhea, then the drug stops this phenomenon and restores the normal functioning of the digestive system.
• According to the manufacturer, the main elements of the drug have a positive effect on all organs of the digestive system, stimulating their work. Ultimately, it is possible to restore the normal digestive process.
• The main components of the drug are completely eliminated from the body naturally after two hours.
• If there is alcohol in the blood, the drug continues to remain in the body and negatively affect the functioning of the liver and kidneys.

When to use: list of indications

Trimedat is prescribed to normalize the motility of the digestive organs and establish increased sensitivity due to contractions of muscle tissue. The drug helps to weaken the intestines, while increasing pressure on the sphincter, which allows overdigested or rough food to be easily eliminated from the body.

REFERENCE! The effect after taking Trimedat occurs within 2-4 hours. The breakdown products of the tablets are concentrated in the liver and excreted in the urine.

For what specific diagnoses and pathologies is the drug prescribed?

• Irritable bowel syndrome (IBS).
• Increased gas formation (flatulence) and bloating, constipation and colic.
• Intestinal obstruction in the postoperative period.
• Stomach upset: pain, early satiety. Some chronic diseases (gastritis, ulcers).
• Preparation for an x-ray procedure or endoscopy of the gastrointestinal tract.
• Symptoms of intoxication in children (nausea, vomiting, constipation).

Possible negative reactions

Side effects may be absent or may vary in severity.

According to the instructions for Trimebutin, the following negative reactions are possible:

• dry mouth;
• violation of taste perception;
• diarrhea or constipation;
• dyspepsia;
• stomach ache;
• heartburn;
• nausea;
• dizziness;
• drowsiness;
• fatigue or weakness;
• feeling hot or chills;
• headache.

In case of overdose of the drug, gastric lavage is recommended, as well as symptomatic treatment.

According to studies, trimebutine does not have teratogenic, mutagenic or carcinogenic potential.

Recommendations and reviews from doctors regarding the use of Trimedat for gastrointestinal diseases

Trimedat, in its action and indications, is a universal medicine; it gives a quick positive effect in functional and chronic digestive disorders; its use is rarely accompanied by side effects. Due to the absence of contraindications, it is used in pediatric medical practice. Therefore, most of the reviews from doctors about the drug are positive. It is often prescribed for various pathologies of the digestive system, and is also used to prevent gastrointestinal disorders. Despite its high safety, self-medication with Trimedat is unacceptable: the medicine is prescribed by a doctor after the necessary examination. He also monitors the intake and results of therapy, adjusts the dosage and timing of treatment. If you strictly follow all the specialist’s instructions, the problem can be dealt with in a short time.

Differences between Trimedat and Trimedat Valens

In pharmacy kiosks you can buy two types of the drug - Trimedat and Trimedat Valenta. The components and effects of the drug on the body are the same.

The difference is that Trimedat is produced by a South Korean pharmaceutical company, and Trimedat Valenta is produced by a domestic pharmacological company. The Russian drug is no different in quality from its Korean counterpart.

Trimedat

Trimedat Valens

Cost of medicines

Prices for the main analogues of Trimedat depend on the country in which they were manufactured. Substitutes of domestic, Ukrainian and Belarusian production are several times cheaper than foreign generics.

List of generic drugs Trimedat with prices in Russia

Interestingly, the Korean drug itself is a generic version of the French drug Debridate, which has been successfully used since the 70s of the last century. In Russia, the medicine with the updated trade name has been sold since 2007. For almost half a century, new generics based on trimebutine have been created. These include:

• Trimedat Forte (“JSC Valenta”, domestic production - cost for 20 tablets - 661 rubles,
• Trimebutin (joint production between Korea and Russia), depending on the number of tablets in the package, costs 271–501 rubles,
• Trimpa (India) - 335 rub.,
• Neobutin (Russia) - 350-440 rubles,
• Neobutin retard (South Korea) - about 500 rubles,
• Tribudate (India) - available in the form of tablets and suspensions with a reduced dosage, used in pediatrics - 350 rubles.

The cheapest analogues of Trimedat

As shown, among Indian drugs, you can choose full-fledged analogues of Trimedat for the active substance, but at a lower cost. Cheap means include:

• No-spa, tablets - 37 rubles.
• Kolofort, tablets - 286 rubles.
• Sparex, capsules (mebeverine base) - 365 rub.
• Betamax is produced in Latvia, tablets (sulpiride base) - 340 rubles.
• Trigan-D, tablets from India, based on dicycloverine together with paracetamol - 120 rubles.
• Niaspam (India) from the mebeverine group, capsules - 387 rub.

Trimedat analogues cannot be used purely mechanically. We have shown different effects and possible negative consequences. The drug must be prescribed by a doctor. You need to go to the pharmacy with an individual list of approved medications. Sometimes it is more important not to skimp on your health.

Bowel diseases

Trimedat stops the reaction of the muscular wall of the colon to a food irritant. The drug restores the normal activity of the intestinal muscles in gastrointestinal pathologies. This means that this medication:

• effective for functional disorders,
• relieves symptoms during exacerbation of chronic colitis,
• relieves symptoms associated with food poisoning and infectious diseases.

May be prescribed:

• as a symptomatic remedy for a short period of time,
• as part of complex therapy for the treatment of chronic pathology.

Indications for the use of Trimedat are intestinal imbalance, which occurs as a result of:

• IBS with functional disorders,
• atony after surgical treatment,
• preparation for colonoscopy and x-ray examination,
• dyspepsia not associated with infectious agents.

Irritable bowel syndrome

IBS is the most common and studied form of functional gastrointestinal disorders. It affects 25% of the population and is considered a multi-etiological disease. Most often it is a manifestation of neurosis and is manifested by functional disorders of the intestine. They are combined into a symptom complex, including:

• pain along sections of the intestine,
• prolonged disturbance of stool character - diarrhea, constipation, or a combination of both.

IBS is a diagnosis of exceptions. Since the etiopathogenesis is not completely clear, an accurate and unambiguous treatment regimen does not currently exist. Symptomatic therapy is mainly used. Trimedat is one of the drugs that allows you to get rid of numerous symptoms of pathology. Trimedat is effective in cases of IBS as a drug that quickly relieves abdominal pain, which is caused by:

• abnormal contraction of the smooth muscles of the colon wall,
• spasm - the cause of stool transit disruption.

The drug has an analgesic effect as an antispasmodic and at the same time a regulator of gastrointestinal motility, normalizing the activity of the intestinal muscles.

The use of Trimedat for IBS depends on the phase of the disease and the severity of functional intestinal disorders at the time of treatment. In the acute period, when the patient has many complaints, the medicine is prescribed 200 mg three times a day for 4 weeks. In the future, to obtain stable remission, treatment with Trimedat must be continued at a dosage of 100 mg × 3 times a day for 12 weeks in a row, without interruptions. This scheme allows you to simultaneously prevent the return and worsening of symptoms.

For severe irritable bowel syndrome, another scheme is used:

• 600 mg per day (0.2 g three times a day) for 1 month,
• after which - 300 mg per day (0.1 g × 3 times a day) for 12 weeks.

Such treatment in almost 100% of cases leads to a complete cure of functional disorders.

Trimedat treatment of severe functional disorders should be monitored using instrumental examination. An effective method is peripheral electrogastroenterography. With its help, the motility of the stomach and all parts of the intestine is determined before, during and after treatment. Observations have shown that after the therapeutic course the following occurs:

• equalization of electrical activity of the duodenum and jejunum,
• improving their motor skills,
• increasing the coefficient of rhythmic contractions of the colon.

As a result, the main clinical symptoms of IBS gradually disappear.

Trimedat for colitis

Trimedat guarantees the restoration of intestinal motility and peristalsis, and in case of exacerbation of colitis, it helps not only to relieve pain, but also to restore stool and reduce flatulence. Equally effective for atonic and spastic colitis. This pathology, along with obesity, hypertension and allergies, is considered a disease of the century due to widespread adynamia, stress, poor nutrition, and environmental conditions.

Spastic colitis most often develops after acute gastroenteritis, constant errors in the diet - frequent consumption of coffee, alcohol, carbonated drinks, rough food. Its manifestations intensify with lack of sleep, psycho-emotional stress, climate change, and during menstruation.

The use of Trimedat for diarrhea is effective, and the drug is also successfully used for constipation. Treatment can begin only after the diagnosis has been clarified. The action of the drug is aimed at relieving spasms (for spastic colitis) or increasing peristalsis (for atonic colitis).

Will Trimedat help with flatulence?

Bloating is accompanied by unpleasant sensations that significantly reduce the quality of life. The abdomen enlarges due to intestinal loops swollen with gas. This causes a feeling of fullness, pressure and heaviness in the abdomen; patients complain of rumbling, belching of air, and involuntary release of gas. If the condition is caused by impaired motility of the intestinal wall, Trimedat is suitable for providing quick assistance because:

• relaxes spasmodic areas,
• increases motor skills in atony,
• ensures uniform passage of feces throughout the entire lumen of the intestinal tube.

This leads to normalization of stool and disappearance of flatulence. Trimedat for bloating is prescribed to children from the age of three.

How to cure diarrhea and constipation with Trimedat

One of the signs of colitis is the appearance of diarrhea or constipation. Trimedat changes intestinal motility and peristalsis in such a way that the process of bowel movements and the structure of feces are normalized. With diarrhea, the smooth muscles of the intestine are relaxed, which leads to atony. But loose stools, like the formation of hard feces, can also form with increased intestinal tone. The drug normalizes altered muscle tone of the intestine and acts on the sphincters of the esophagus, stomach and intestines.

For diarrhea, Trimedat is prescribed in cases of chronic pathology or for functional disorders, when frequent loose stools appear after stress and anxiety - bear disease. In this case, infectious factors (viruses, pathogenic bacteria or fungi) and toxins. Diarrhea occurs due to intestinal dysfunction. There is a rapid and rhythmic contraction of the intestinal wall, accelerated movement of feces. Water does not have time to be absorbed, and loose stools form. Therefore, with proper treatment of diarrhea, the consistency of stool is restored and the rhythm of contractions of the intestinal wall is normalized. Trimedat is ideal for this purpose. It is a universal regulator of gastrointestinal motility with a triple mechanism of action.

If there is no effect and increased pain, diarrhea, nausea, vomiting, severe weakness, hyperthermia, therapy should be stopped and urgently consult a gastroenterologist or therapist and undergo further examination to clarify the diagnosis. The duration of treatment, frequency of administration, and dosage are determined only by the doctor.

In the presence of chronic colitis with stool disorders, the drug is prescribed in the acute phase and for prophylactic purposes. The drug does not eliminate the causes of diarrhea or constipation, therefore it is used as a symptomatic component of complex treatment with other drugs.

Acute diseases accompanied by the development of diarrhea require a thorough examination to determine the causes, after which etiological and pathogenetic therapy is carried out.

Trimedat effectively treats constipation with any mechanism of its formation. The drug is prescribed for constipation associated with the following diseases:

• atony due to a sedentary lifestyle or as a result of surgery,
• intestinal spasm as a result of intestinal colic,
• overeating or poor nutrition, leading to difficulty passing stool through the intestines,
• digestive disorders caused by pathology of the stomach, pancreas, gallbladder,
• neurological changes associated with stress, overwork (increased tone of the anal sphincter).

Self-administration of Trimedat for constipation is prohibited: this may aggravate the condition. When treating with the drug, examination is necessary to exclude intestinal obstruction of various etiologies, including neoplasms. At an early stage, diagnosis of these pathologies is difficult and requires additional methods.

Contraindications to the use of Trimedat for constipation are:

• liver dysfunction,
• acute pancreatitis,
• sharp pain in the abdomen with deterioration in general health,
• intestinal bleeding,
• pregnancy.

Despite the fact that Trimedat is approved for use in late pregnancy, it is not recommended for constipation. Increased peristalsis can provoke premature labor due to possible contractions of the uterus due to its anatomically close location to the intestines. The drug is used in pregnant women only to prevent constipation.

For adults, the medicine is prescribed 100 or 200 mg three times a day. The pediatric dosage is determined by the doctor, depending on the age and severity of the condition. The duration of treatment depends on the severity of clinical manifestations.

Comparison of Trimedat with other analogues

Some drugs offered as substitutes for Trimedat have an even higher price. Cheap medications need to be studied according to the instructions; they only partially perform the functions of Trimedat. Most have an antispasmodic effect, but do not increase sphincter tone or eliminate reflux.

More expensive, for example, Duspatalin (produced in the Netherlands), Ganaton (Germany). Antispasmodics do not have a sufficient comprehensive effect on the patient’s body. But if Trimedat is contraindicated, analogues can be used in therapy on the recommendation of a doctor. Pharmacists include the following in their list of possible substitutes:

• Motilium in tablets and suspensions.
• Duspatalin and Duspatalin Retard in tablets and capsules.
• Halidor, tablets, injection solution.
• Enterosan, capsules.
• Dicetel, tablets.
• Iberogast, drops.
• Niaspam, capsules.
• Pepsan-R, gel and capsules.
• Mucofalk, in granules.
• Spasmomen, tablets.

When choosing, doctors are guided by the main symptoms: if pain comes first, then Duspatalin is recommended, but with simultaneous symptoms of diarrhea, constipation, and intestinal irritation, Trimedat is more indicated. You should remember the negative manifestations of therapy. Duspatalin often causes:

• bowel dysfunction (constipation, diarrhea),
• allergic reactions,
• migraine-type headaches with nausea and vomiting.

Motilak is an example of a similar action, but a completely different composition. It is produced by a Russian pharmaceutical company in tablets for resorption and swallowing, the active ingredient is domperidone. In gastroenterology it is used to speed up the passage of food through the stomach, preventing stagnation and increased pressure in the stomach. The drug is effective for reflux esophagitis, in the treatment of belching and heartburn. Eliminates flatulence, bursting pain in the epigastric zone. Indicated in the treatment of parkinsonism with Levodopa and Bromocriptine. Price — 290 rub.

Another example is the French drug Meteospasmil - antispasmodic properties are formed due to the simultaneous effect of simethicone and alverine. By eliminating gas formation by destroying bubbles, the medicine reduces irritation of the inner lining, stretching of intestinal loops, and stimulates additional mucus production for protection. A package of 30 capsules costs 430 rubles.

Trimedat: what kind of drug is it and how can it help with gastrointestinal problems

According to various classifications, Trimedat simultaneously belongs to the following groups:

• synthetic anticholinergics,
• antispasmodics,
• drugs intended to treat disorders.

In the pharmaceutical market, the drug is known by two names:

1. Trimedat (manufacturing country - South Korea).
2. Trimedat Valenta (Russia - first appeared under this name in 2008).

They differ in appearance and some composition of excipients: in the Russian version, povidone is additionally present. This component accelerates the dissolution of the drug and increases its bioavailability.

Trimedat is available only in tablet form in three doses: 100, 200 and 300 mg. Trimedat Forte, which has a high dose of the active substance (300 mg), is intended for a single dose during the day, in severe cases it is prescribed twice a day.

The main active component of Trimedat, trimebutine maleate, has an affinity for the chemical structure of intestinal receptors, which are involved in the stimulation and relaxation of its smooth muscle cells. Affects the humoral regulation of the digestive organs:

• increases the level of motilin, a hormone that regulates gastrointestinal motility,
• reduces the synthesis of other hormones produced in the pancreas that are involved in digestive processes - glucagon, gastrin, VKP (vasoactive intestinal peptide), pancreatic polypeptide.

Therefore, the drug has a stimulating effect on the muscles of the digestive tract in case of their hypotonicity and acts as an antispasmodic in their hyperkinetic state. This achieves relaxation of the sphincter and stimulation of peristalsis of the large intestine, which facilitates daily bowel movements.

The drug, according to the official instructions, regulates the motility of the entire digestive tract, but mostly the intestines. The intensity of peristalsis in all its parts is leveled out and becomes uniform. As a result, the passage of the food bolus improves and its progress accelerates: it moves evenly along the digestive tube, without stopping or quickly skipping any parts of the intestine. In this regard, many symptoms associated with impaired peristalsis are relieved:

• nausea, accompanied in many cases by vomiting,
• diarrhea or constipation,
• flatulence,
• pain in the epigastrium and along the intestinal segments.

In addition to trimebutine, the drug contains a number of additional components: lactose, silicon dioxide, starch, talc.

The drug is taken on an empty stomach, washed down with clean water, there is no need to chew the tablet. Standard treatment regimen: 1 tablet three times a day. Medicine is prescribed to a child from the age of three. The dose depends on the pathology and age:

• 100-200 mg once, the maximum daily dose is 600 mg - from 12 years,
• 50 mg (up to 150 mg per day) - from 5 to 12 years,
• 25 mg (no more than 75 mg per day) - from 3 to 5 years.

The course of treatment can last up to 3 months. The duration of therapy is determined by the doctor and prescribed individually, depending on the specific pathology and its severity. Exceeding the specified dosages leads to side effects from many organs. React:

• nervous system – causeless anxiety or lethargy, drowsiness, headaches of various localizations, hearing loss,
• Gastrointestinal tract - unpleasant taste and feeling of dry mouth, stool disorders, dyspepsia:
• genitourinary system – gynecomastia, menstrual irregularities, urination,
• skin - allergic rashes.

Effect of alcohol

Ethyl alcohol, entering the human body, passes through the gastrointestinal tract and places stress on the liver. Getting into the larynx and further, moving through the gastrointestinal tract, alcohol has an effect on the mucous membrane.

With frequent use of ethanol, it becomes thinner and can become covered with erosions. Alcohol while taking Trimedat is not advisable and even dangerous.

For your information! Regular consumption can lead to chronic disorders of the digestive system.

When alcohol enters the body, increased secretion of stomach acid occurs. If the walls are already thinned, then lesions and ulcers may even appear. And additional portions of alcohol only worsen the condition, even to the point of bleeding.

Ethanol, as well as its breakdown products, are toxic substances that are harmful to the liver. With frequent and significant ingestion of alcohol into the body, the condition of the liver worsens. It ceases to cope fully with the load, becomes covered with scars and undergoes changes in tissue structure.

In addition, drinking alcohol can lead to the following symptoms:

• hepatic colic;
• cholestasis;
• pancreatitis, etc.

Alcohol after therapy

Trimedat must be used daily for a certain period. Because of this, its concentration in the blood increases. The drug is completely eliminated from the blood within 24 hours.

Only after this period is it possible to drink alcohol. A one-time intake of alcohol is possible after consultation with a doctor if there are no contraindications and there is a low risk of side effects.

Treatment with Trimedat is quite long. For it to be effective, you need to give up bad habits during therapy. The body's reaction to alcohol varies depending on individual characteristics.

Compatibility of Trimedat and alcohol

Ethyl alcohol entering the stomach causes a chemical burn to the mucous membranes, thereby affecting the functioning of the organ. In people with addiction, the mucous membrane of the gastrointestinal tract is thinned and also covered with a large number of ulcers and erosions. Chronic drinking can lead to the development of chronic inflammation.

Alcohol stimulates the production of gastric juice, which is based on hydrochloric acid. Its excess in the organ causes the formation of ulcers and erosions. The walls of the mucous membranes are quite thin, so they soon begin to bleed; with subsequent unlimited consumption of alcohol, there is a risk of gastric and esophageal bleeding.

Ethanol metabolites also destroy hepatocytes, whose main task is to remove toxins from the body. With alcoholism, liver cells do not have time to recover, which is why the detoxification function of the organ is disrupted.

In places of dead hepatocytes, connective tissue is formed, which prevents further restoration of the liver, which leads to the development of cirrhosis.

The drug molecules do not interact with ethanol, but the consequences of their combined use may occur. Doctors do not recommend combining these products together.

Conditions for dispensing the drug, storage rules

Trimedat is available in pharmacies without a prescription. For a guaranteed shelf life of three years, moderate room temperature and the absence of high humidity are required. The storage location must be out of reach of children.

The drug trimedate contains trimebutine, a substance that affects the release of enkephalins.

Enkephalins are neuropeptides (five amino acid residues) that have an opioid-like effect. They have nothing to do with drugs! They are produced in the nervous system and locally in the nerve ganglia of any organs and systems. They normalize the activity of smooth muscles and have a strong analgesic effect. Enkephalins are short-lived molecules that circulate within several cell layers and do not enter the systemic circulation.

Depending on the initial state of the gastrointestinal tract, it stimulates or suppresses peristalsis. Promotes emptying of the stomach and gallbladder, normalizes intestinal motility. Indicated for GER (normalizes the tone of the esophageal sphincter, prevents the backflow of acidic contents into the esophagus), IBS with constipation/diarrhea, paralytic intestinal obstruction, and other functional digestive disorders in children and adults.

The drug is well absorbed from the intestine, circulates in the blood in a free form, is metabolized in the liver and excreted through the kidneys. It almost does not penetrate the placental and blood-brain barriers; it “works” mainly in the intestinal lumen, acting directly on smooth muscle cells.

Trimedat has a high safety profile; it can be used in children from 3 years of age, and earlier on the recommendation of a doctor. There are a lot of domestic works regarding the positive experience of using Trimedat for constipation in children and IBS in adults.

Dosage regimen: 100 or 200 mg (as recommended by a doctor or according to the severity of symptoms) 3 times a day. To prevent relapses of IBS, it is necessary to take the drug according to this regimen for at least 3 months. For children from 3 years old - 25 mg (a quarter of a tablet), from 5 to 12 years old - 50 mg (half a tablet) three times a day.

Joint use of Trimedat and alcoholic beverages: what happens in the body when they interact

The active compound of the drug Trimedat is trimebutine in the form of maleate. It affects specific receptors of the intestinal enkephalinergic system. As a result, a modulating effect is realized, which includes:

1. Increased tone of smooth muscles in the walls of various parts of the hollow structures of the digestive tract during hypokinetic conditions (insufficient contraction of smooth muscles).
2. Antispasmodic effect, which is realized against the background of increased tone.

The substance reduces pressure in the esophagus by reducing the tone of the esophageal sphincter, promotes rapid gastric emptying, and affects the receptors of the intestinal walls throughout. The instructions indicate that the molecules of the main compound and alcohol do not interact with each other.

Alcohol begins to be absorbed from the gastric mucosa (20% of the total dose taken). Most of it enters the blood from the lumen of the small intestine. It does not directly interact with trimebutine, but has physiological antagonism (opposite effect), which includes the following manifestations:

1. Decreased tone and intensity of peristalsis (wave-like movements of the walls aimed at pushing contents into the lower sections) of all parts of the digestive system.
2. An irritating effect on the mucous membrane, as a result of which a local pronounced spasm of the small intestine develops, leading to a sharp limitation in the passage of food.
3. Stimulation of the activity of the digestive glands when a small volume of alcohol is consumed, followed by inhibition of enzyme synthesis.

With the systematic consumption of alcoholic beverages against the background of alcoholism, the risk of developing hypertensive intestinal paresis with a complete absence of peristalsis and diseases of the digestive system (toxic hepatitis, acute or chronic pancreatitis, gastritis, enterocolitis) increases.

In case of simultaneous use, alcohol practically neutralizes the pharmacological effects of the drug due to antagonism. It has a diuretic effect. This leads to accelerated excretion of trimebutine from the body in the urine, as a result of which the duration of the therapeutic effect is also reduced.

Therapy for gastritis and ulcers

Trimedat affects the entire digestive tract, relaxes the duodenogastric sphincter, promoting rapid gastric emptying by increasing peristalsis. Thus, it acts on the clinical manifestations that accompany exacerbation of gastritis or ulcers, and also eliminates functional disorders that arise from errors in diet and overeating. Therefore, it is prescribed as a symptomatic remedy to eliminate discomfort and dyspeptic symptoms or as part of complex therapy for gastric pathology. This is possible thanks to the mechanism of action indicated above - the drug normalizes peristalsis:

• accelerates with insufficient contraction,
• reduces it when there is excess.

In addition, the medicine acts as an antispasmodic: it reduces the increased tone of smooth muscles. This leads to relief of spastic pain.

The maximum course of treatment for gastroduodenitis and ulcers is 60-90 days (for adults and children). If necessary, after control studies, therapy is repeated for 30 days. The medication continues until all clinical symptoms disappear completely.

General information about the medicine

According to the instructions for use of Trimedat, the main active component of the drug is trimebutine. They produce two types of tablets containing 100 or 200 milligrams of the active substance. In addition to negs, the preparation contains a number of chemicals that ensure the preservation of the shape of the tablets and their activity: talc, milk sugar, starch and silicon dioxide.

The tablets are produced in standard blisters of 10 pieces. The total number of tablets in one package is from 10 to 30. Trimedat 200 and 100 differ from each other in the dosage of the active substance, which must be taken into account when purchasing a medication.

According to reviews from doctors, after purchase Trimedat must be stored in a dark, cool place to eliminate the impact of negative factors on the tablets in the form of high humidity, temperature and sunlight. Also, the medicine should be inaccessible to children due to the risk of poisoning.