Zalain suppositories: instructions for use, composition and analogues of the drug

Compound

1 gram of cream contains 20 mg of sertaconazole nitrate .
Additionally: 20,000 mg ethylene glycol and polyethylene glycol palmitostearate, 5,000 mg saturated polyglycolyzed glycerides, 2,000 mg glycerol isostearate, 8,000 mg paraffin oil, 100 mg sorbic acid, 100 mg methyl p-hydroxybenzoate, up to 100,000 mg purified water.

1 suppository includes 300 mg of sertaconazole nitrate .

Additionally: 1305 mg suppositir, 1305 mg witepsol, 90 mg colloidal anhydrous silicon dioxide.

Composition and release forms

Types of the drug "Zalain"

The drug "Zalain" is presented in several dosage forms. It is available in the form of a suppository for insertion into the vagina and a cream for external treatment of infected areas. This medicine does not exist in tablet form.

The active substance of the drug is sertaconazole. Each 1 g of cream contains 20 mg. Vaginal suppositories contain 300 mg of the active ingredient.

The cream has a pleasant consistency. It is painted white. The drug is sold packaged in aluminum tubes, each of which contains 20 g of the composition.

In addition to the active component, the cream contains excipients:

1. Ethylene glycol;
2. Polyethylene glycol;
3. Palmitostearate;
4. Glycerides, glycosylated;
5. Glycerol isostearate;
6. Paraffin oil;
7. Sorbic acid;
8. Purified water.

Vaginal suppositories are characterized by an oval shape. They have a waxy consistency. The candles are painted white. The auxiliary components in the drug are:

1. Suppocir;
2. Silica;
3. Witepsol.

The complete composition of the medicine "Zalain" in different dosage forms is contained in its instructions for use.

Pharmacodynamics and pharmacokinetics

Zalain suppositories and ointment are an antifungal remedy whose active ingredient is a derivative of benzothiophene and imidazole . Local application of therapeutic dosages of the drug is characterized by fungicidal and fungistatic effectiveness. The central mechanism of action is aimed at suppressing the processes of ergosterol and increasing the permeability of mycotic cell membranes , which is actually the cause of lysis of the fungal cell .

The antifungal activity of the drug extends to strains of fungi of the genus Candida . Antibacterial effectiveness is manifested against gram-positive microorganisms ( Staphylococcus and Streptococcus ).

When applied topically, sertaconazole nitrate is not detectable in blood or urine. When used intravaginally, absorption of the active ingredient of the drug is not observed.

Pharmacological group

Zalain is classified as an antifungal agent.

This medication is a broad-spectrum drug, a derivative of imidazole and benzothiophene.

Zalain cream is active in the fight against pathogenic fungi Candida albicans, Candida spp., Candida tropicalis, dermatophytes Trychophyton spp., Pityrosporum orbiculare, Microsporum spp. and causative agents of infectious lesions of the skin and mucous membranes (gram-positive strains of Streptococcus spp. and Staphylococcus spp.). Produces fungistatic and fungicidal effects.

The effect observed as a result of the use of sertaconazole is due to the inhibition of ergosterol production and an increase in the level of cell membrane permeability, which leads to the destruction of the fungal cell.

Indications for use

Zalain cream is indicated for use for the treatment of superficial skin mycoses , including: mycoses of the hands , feet and legs ; mycoses of the beard ; mycoses of the trunk ; pityriasis versicolor ; candidiasis .

Zalain suppositories are prescribed for local treatment of infections of the vaginal mucous membranes caused by strains of fungi of the genus Candida ( thrush / vulvovaginal candidiasis ).

Composition of candles

A drug for the treatment of infections caused by pathogenic fungal bacteria has one active component, due to the presence of which it has a positive effect. “Zalain”: the active ingredient is sertaconazole, the mass fraction of which is 300 mg in each individual suppository.

In addition, the candles also include additional elements:

• semi-synthetic solid glycerides;
• this also includes suppositir;
• Viseptol;
• and anhydrous colloidal silica.

Additional elements contained in candles do not have a healing effect.

Side effects

When using the cream, the formation of local reactions, manifested in the form of contact dermatitis . They also allow for the possibility of developing transient erythematous phenomena that do not require cessation of treatment.

Suppositories for thrush occasionally led to allergic manifestations , as well as burning / itching sensations in the vagina , which did not require discontinuation of the drug and disappeared on their own with further therapy. These side effects are classified as classic effects observed with the use of local vaginal dosage forms and reflect the effectiveness of the drug.

Side effects

The use of the drug, in rare cases, can provoke the occurrence of undesirable side reactions:

• As the instructions say, during treatment with the drug, a woman may experience such unpleasant symptoms as severe burning, redness or itching, but these symptoms do not require any solution; they go away on their own. In this case, there is no need to cancel treatment;
• in extreme cases, a side effect may occur, which manifests itself in the occurrence of an allergic reaction of the body.

It should be noted that the use of Zalain suppositories is quite well tolerated by patients, and therefore side effects are extremely rare.

Instructions for use of Zalain

Cream Zalain, instructions for use

Proper use of the cream involves applying it evenly in a thin layer to the infected areas of the skin, covering about 1 cm of healthy skin around the problem area. The recommended frequency of use of the drug is 2 times every 24 hours, with the duration of therapy depending on the etiology of the pathogen and the infectious localization (most often 4 weeks). Disappearance of symptoms of infection is usually observed after 2-4 weeks.

It is not recommended to simultaneously use other local antifungal drugs (ointments, solutions, gels, etc.).

Zalain suppositories, instructions for use

Vaginal suppositories of the drug are intended for single use. One suppository, previously removed from the blister, should be inserted deep into the vagina. This procedure is recommended to be performed before going to bed in a horizontal (lying on your back) body position. of thrush persist, you can repeat the procedure for introducing a suppository after 7 days.

Immediately before inserting the suppository, hygiene of the external genital organs should be carried out using alkaline or neutral soap .

Indications

The drug is intended exclusively for the local treatment of various pathologies caused by inflammatory and infectious pathogens. The use of suppositories will be relevant if a woman has diseases such as:

• thrush;
• fungal infections of the vagina - candidiasis;
• vulvovaginitis.

It should be noted that Zalain suppositories provide an opportunity for a woman to be cured even when taking the pills becomes ineffective or does not bring the expected result.

The use of the drug for diseases such as thrush and vulvovaginitis is due to the effect of sertaconazole on the vaginal mucosa, due to which the source of infection is eliminated and harmful fungi are destroyed.

special instructions

The drug cream is not intended for use in ophthalmic practice.

When applying the cream, the use of acidic hygiene products , due to the increased proliferation of Candida fungal strains in an acidic environment.

In the case of suppository therapy with a parallel observed infection of the labia and surrounding areas of the skin ( candidal vulvitis ), additional local use of Zalain cream is recommended.

Administration of suppositories of the drug during menstruation .

During the therapeutic effect of the suppository, sexual intercourse is undesirable.

In order to prevent urogenital reinfection, the issue of parallel therapy of the sexual partner should be considered.

The possibility of damage to contraceptive barrier devices (rupture of the diaphragm or condom) increases during the action of the active ingredient of the suppository.

Price

The price of Zalain candles varies between 520 rubles. per package containing one suppository.

The cream is available in the form of an aluminum tube with a volume of 20 mg, its cost is about 380 rubles.

Storage conditions and shelf life

Candles must be stored in a dark place, inaccessible to small children, at a general temperature that does not exceed 30°C. This indicator for cream is no more than 25°C. The drug can be stored for a maximum of 3 years.

special instructions

If candidal vulvitis has affected areas not only of the labia, but also of adjacent skin, it is necessary to use the drug not only in the form of suppositories, but also externally in the form of a cream.

Menstruation is not a reason to stop using Zalain. During treatment, it is recommended not to have sexual intercourse at all. To avoid infection of a sexual partner, simultaneous treatment should be considered. The use of Zalain may weaken the effect of oral contraceptives, as well as damage barrier contraception.

Zalain's analogues

Level 4 ATC code matches:
Daktarin

Oronazole

Isoconazole

Kandibene

Miconazole

Candide B

Nizoral

Kanesten

Mifungar

Ecodax

Econazole

Clotrimazole

Travogen

Keto Plus

Bifonazole

Sebozol

Mycozolon

Mycozoral

Travocort

Mycospor

Below are preparations for topical use, which are the most popular analogues of the remedy Zalain.

For cream (ointments, sprays, creams, powders, gels, solutions):

• Amyclone;
• Kandibene;
• Bifonazole;
• Clotrimazole;
• Dermazol;
• Candide;
• Mycozoral;
• Funginal;
• Mycospor;
• Nizoral , etc.

For suppositories (vaginal capsules, suppositories, creams, tablets):

• Ginalgin;
• Clotrimazole;
• Ginofort;
• Kandibene;
• Livarol;
• Candide;
• Metrogil;
• Pimafucin;
• Metronidazole;
• Neo-Penotran;
• Trichopolum;
• Mikogal;
• Klion-D , etc.

Zalain suppositories for thrush

Before starting treatment for thrush, it is important to understand the causes of the disease, because effective treatment is associated with the elimination of the provoking factor.

Common causes of the disease are the following factors: hypothermia, stress, diabetes, poor intimate hygiene, use of antibiotics as self-medication, etc.

During treatment, it is important to consider some features of zalain:

• You can use vaginal suppositories after consulting a doctor;
• the dosage of the drug is determined by the doctor after laboratory tests and diagnosis;
• exceeding the dosage will not bring anything good;
• Before starting treatment, you should carefully study the instructions;
• It is important to follow all the advice included in the complex therapy.

The drug is administered once a day in the evening. The product is injected as deeply as possible, preferably in a supine position. Usually one application is enough for complete cure.

Zalain can be used during menstruation. For recurrent forms of thrush, a second course of treatment may be required after a week. If you are hypersensitive to the main components of the drug, you should not use suppositories.

Zalain during pregnancy (and lactation)

The instructions for the drug allow the use of Zalain cream and suppositories during pregnancy and lactation , only after an individual assessment by a doctor of the risk/benefit ratio for the woman/child (fetus), which is confirmed by both positive and negative reviews about Zalain during pregnancy and lactation of women, when - have been treated with this drug. It is impossible to predict in advance and with accuracy the response of the female body to the action of the active ingredient of the drug and its effect on the fetus/child, and therefore during these periods it is better to do without the use of “chemistry”.

Pharmacological properties of suppositories

Due to the high content of the active component sertaconazole in Zalain, suppositories have a detrimental effect on the vital activity of various types of fungi. The active substance of the drug suppresses the ability of pathogenic organisms to reproduce, due to which the population of fungi is reduced and destroyed.

Suppositories have the greatest detrimental effect on a group of fungi such as candida. Moreover, this drug has an antibacterial effect on harmful bacteria such as staphylococcus and streptococcus. Due to its complex effects, the drug does not cause addiction in patients and significantly reduces the risk of relapse of pathologies.

It is important to note that the active ingredient sertaconazole, which is included in the suppositories, is not an antibiotic. Therefore, Zalain is a relatively safe and effective drug used in the treatment of infections caused by fungi in pregnant and lactating women. Thus, pregnancy is not considered a clear contraindication to the use of this drug.

Reviews about Zalain

In comparison with other creams and ointments that have a similar antifungal effect, reviews of Zalain cream are significantly more positive. Many patients who have experienced several similar local preparations give the best assessment of the effectiveness, duration of action and safety of Zalain and recommend this cream to all their friends suffering from the same infectious diseases .

Reviews about Zalain suppositories are also in most cases positive and often speak of the effective treatment of thrush using only one suppository. In turn, comparing analog drugs in terms of safety and frequency of recurrence of infection and based on their own experience, some women advise using these suppositories during pregnancy , but warn against self-prescribing such treatment in favor of a mandatory decision on the possibility of antifungal therapy by a doctor.

Reviews

Nikolay, 42 years old I myself work as a dermatologist. Through negligence, he became infected with a fungus from a patient. I decided that this drug would best cope with the disease. “Zalain” in the form of a cream was used daily to treat the problem area that was affected by infection. It only took me 2 weeks to completely forget about the unpleasant symptoms of this disease. I will continue to use the cream for a while to prevent the fungus from reoccurring.

Valentina, 30 years old I am worried about such a problem as chronic thrush. Therefore, from time to time I have to undergo therapy for a fungal infection in the intimate area. I was once treated with Zalain in the form of suppositories. But over time, the drug stopped working. Therefore, I had to switch to another medicine. Most likely, this product is simply not suitable for continuous use. So it is better to use it for simple thrush, rather than chronic.

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Zalain price, where to buy

If we compare the cost of other local antifungal drugs analogues (including ointments, sprays, creams, solutions, etc.), as well as other similar suppositories for thrush, the purchase of any of the dosage forms of Zalain may seem like a waste of money, which is most often offset by the high efficiency and cost-effectiveness of drug use.

Today, the price of Zalain cream varies between 450-550 rubles, and the price of Zalain suppositories fluctuates around 500-600 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Zalain suppositories vaginal.
  300 mg Trommsdorf GmbH and CO KG/Laboratory Teramex 521 RUR order
• Zalain cream 2% 20g Ferrer International S.A.

  RUR 524 order

Pharmacy Dialogue

• Zalain suppositories (sup. vag. 300 mg No. 1) Egis

  RUB 634 order

• Zalain cream (tube 2% 20g) Ferrer Inter.

  RUR 578 order

Europharm* 4% discount using promo code medside11

• Zalain vaginal suppositories 300 mg n1Trommsdorff GmbH and Co.KG

  670 rub. order

• Zalain cream 2% 20 gFerrer International JSC

  630 rub. order

show more

Pharmacy24

• Zalain 2% 20 g cream Ferrer International, S.A., Spain/ZAT Pharmaceutical Plant EGIS, Ugorshchina
  126 UAH.order
• Zalain ovula 300 mg No. 1 suppositories ZAT FZ EGIS/Trommsdorff Gmbh i Co KG, Ugorshchina/Nimechchina

  192 UAH order

PaniPharmacy

• Zalain cream Zalain cream 2% 20g Spain, Ferrer Internacional

  145 UAH order

• Zalain ovuli suppository Supp. zalain ovuli vag. 0.3g No. 1 Hungary, Egis

  201 UAH order

  Read also:  Corpus luteum in the ovary during pregnancy. What will the ultrasound say?
• Supp. vag. zalain ovuli 0.3g No. 1 Ukraine, Teramex Laboratory

  241 UAH order

show more

Analogs

Complete analogues of the drug according to the active substance are:

• "Sertazol";
• "Sertaconazole";
• "Sertamicol".

The range of drugs with similar effects is large. But only a doctor can choose the most suitable medicine.

"Zalain" is an effective antifungal drug. Active against many strains of fungi resistant to other drugs. Treatment of thrush with Zalain, indeed, involves the introduction of only one suppository into the vagina. But if necessary, you can additionally use the cream, including for the prevention or relief of symptoms in a sexual partner. Reviews from doctors and patients confirm the high effectiveness and ease of use of the medicine.

https://youtu.be/BKgD_FWwJeY

Analogue drugs

Like most drugs, the drug “Zalain” has analogues and synonyms on the pharmaceutical market.

Synonymous drugs contain a derivative of benzotifene and imidazole as an active substance, just like the drug “Zalain”. Analogues have different active ingredients, but have the same pharmacological effect.

The cream "Zalain" has a synonymous drug in the form of a solution for external use - the drug "Sertaconazole". There are no drugs synonymous with suppositories.

Cream " Zalain", analogues:

• The drug "Bifasam".
• "Amiclon" product.
• Medicine "Bifonazole" in the form of powder, cream, solution.
• Medicine "Bifosin" in the form of spray, powder, solution.
• Spray "Daktarin".
• The drug "Dermazol".
• Ifenek product in powder and cream form.
• Medicine "Imidil".
• Medicine "Candibene" in the form of a solution, cream.
• The drug "Candizol".
• Spray or cream "Canesten".
• Medicine "Clotrimazole" in the form of cream, gel, ointment, solution.
• Medicine "Mycozoral" in the form of shampoo, cream.
• The drug "Mikospor" in the form of ointment, cream, solution.
• Shampoo or cream "Nazoral".
• Medicine "Travogen".
• Funginal product.
• Medicine "Fungitsip".

Preparations-analogs of suppositories “Zalain”:

• The product "Vagiferon".
• Medicine "Ginalgin".
• Medicine "Ginezol" in the form of cream, suppositories.
• The drug "Gino-Pevaril".
• Vaginal tablets "Imidil".
• Ifenek remedy.
• Medication "Candibene" (vaginal tablets).
• Medicine "Kandizol" (vaginal tablets).
• Vaginal tablets "Klion-d 100".
• The drug "Clotrimazole" (vaginal tablets).
• Medicine "Livarol".
• Means "Funginal" (vaginal tablets).