Pharmacological action of Depantol
Depanthol is a combined agent used for topical use with antimicrobial, regenerative and metabolic effects.
Dexpanthenol, which is part of the drug, activates the regeneration of mucous membranes, stabilizes cellular metabolism, increases the rate of mitosis and the strength of collagen fibers.
Chlorhexidine is active against gram-negative and gram-positive microorganisms: Chlamydia spp., Treponema pallidum, Neisseria gonorrhoeae, Ureaplasma spp., Bacteroides fragilis, Gardnerella vaginalis, Staphylococcus spp., Streptococcus spp., Escherichia coli, dermatophytes, yeast, protozoa. Certain strains of Proteus spp., Pseudomonas spp., bacterial spores and acid-resistant forms of bacteria are not sensitive to the action of chlorhexidine.
The drug does not affect the functional activity of lactobacilli. In the presence of pus and blood, it remains active.
Depantol suppositories for thrush. Use for thrush
Whether Depantol treats thrush depends on the type and nature of the disease. The drug exhibits the greatest therapeutic effect for mixed bacterial and fungal infections as part of complex therapy. Depanthol relieves inflammation and swelling, restoring damaged tissue. For targeted treatment of candidiasis, it is better to use drugs that have a proven antifungal effect.
In addition, after successful completion, you need to consolidate the result - normalize the vaginal microflora and monitor the immune system. It is recommended to reduce the proportion of sweets and baked goods in the diet.
Regarding the use of Depantol suppositories for thrush, reviews from patients are mixed. Many women experience intolerance to the drug. Even in the same patient, its use at different times can cause different reactions.
Depantol helps very well in healing wounds after treating cervical erosions for thrush. But if it is impossible to tolerate the burning sensation when using suppositories, then it is better to consult a gynecologist so that he can prescribe a more suitable medication.
Is it possible for pregnant women?
Depantol suppositories are one of the few products intended for the treatment of thrush and other vaginal infections that are approved for use during pregnancy. The components of the drug do not have a systemic effect on the body, showing only a local effect, and therefore will not cause any harm to a pregnant woman and the child she is carrying.
You can buy Depantol suppositories in many pharmacies throughout Russia. To choose the most suitable option for the price, you can call the pharmacy help desk in advance or explore the selection on the Internet.
The average price for Depantol candles is 600 rubles. The price range for this drug in retail pharmacies, especially in large cities, can reach 100 rubles or more. The cost of Depantol varies from 500 to 700 rubles.
Online pharmacies are convenient because many medications are cheaper to order through them. Delivery can be arranged to a pharmacy located near your home. The website shows promotions and discounts that are currently in effect. For the purchase of many medications, additional bonuses are awarded that can be used in further payments.
Indications for use of Depantol
According to the instructions, Depantol in the form of a cream is used as a preventive and therapeutic agent for infected skin lesions, namely for:
- treatment of wounds after operations;
- treatment of infected dermatoses;
- treating wounds if there is a risk of infection (cuts, abrasions, cracks, scratches, scratching, trophic ulcers, burns);
- treatment of burns, infected wounds, bedsores, cuts, abrasions, cracks, diaper rash, trophic ulcers;
- treatment of diaper dermatitis, scratches with signs of infection in children;
- treatment of cracks and inflammation of the nipples on the mammary glands with signs of infection in nursing mothers.
Depantol in the form of vaginal suppositories is used for:
- chronic and acute vaginitis;
- cervical erosion in complex therapy;
- endo- and exocervicitis, including those complicated by cervical ectopia;
and
- after obstetric and gynecological operations, during the postpartum period;
- to improve the regeneration of the mucous membrane of the cervix and vagina after cryodestruction, diathermocoagulation, laser destruction.
Patient reviews
During pregnancy, I developed thrush; my gynecologist prescribed these suppositories because they are harmless and do not affect the fetus. I liked everything, and the thrush went away quite quickly. Good product, I recommend it.
Olga
Hello, the gynecologist prescribed me Depantol after surgery. I had a hormonal imbalance and had to go under the knife. And to restore the microflora, she prescribed these particular suppositories. Now everything is fine, everything is healing quickly. Although the candles are expensive, they are of high quality.
Anastasia
I used the gel to heal tissue after childbirth, everything recovered very quickly, excellent suppositories and no side effects.
Evgeniya
I developed cervical erosion, the doctor prescribed various tablets, suspensions, injections and Depantol.
At first there was a strong burning sensation and irritation. I got scared and went to the doctor. He said it was because of the soap - don't use it when bathing. I've been putting candles on for a week now and nothing, no reactions. I’m very glad, it’s a good product, I recommend it. Alexandra
Directions for use and dosage of Depantol
Depantol cream is intended for external use.
It is applied to the affected area of skin in a thin layer one to several times a day according to indications.
For women breastfeeding, the infected surface of the nipple should be lubricated with cream after feeding.
For infants, the cream is applied after bathing or changing clothes.
Depantol suppositories are intended for intravaginal use.
Before use, Depantol suppositories are removed from the contour packaging and inserted into the vagina.
Suppositories are administered for 7-10 days, 2 times a day.
If necessary, the course of treatment can be extended to 20 days.
Depanthol
Depantol (dexpanthenol + chlorhexidine bigluconate) is a tissue repair stimulator for local use in gynecological practice (vaginitis, cervicitis, cervical erosion, etc.), incl. after diseases that developed after childbirth. According to WHO statistics, postpartum gynecological pathologies are detected annually in more than 20 million women who give birth. Unfortunately, even with the high level of development of modern medicine, deaths cannot be ruled out, one of the causes of which is infections. Transient immunodeficiency, which develops in women in labor, causes a slowdown in reparative processes in tissues injured during childbirth and a high susceptibility of women giving birth to various types of infections. Thus, one of the tasks of doctors is to activate tissue repair processes in combination with preventive measures aimed at preventing the development of infections. The list of antibacterial agents approved for use in nursing women is very narrow, so the problem of counteracting infectious damage to tissues damaged during childbirth is more relevant than ever. To prevent pathogenic bacteria from entering the body, drugs based on chlorhexidine are used. One of such medicines, in which this antiseptic is contained in combination with an effective wound healing agent dexpanthenol, is Depantol. Chlorhexidine is active against chlamydia, ureaplasma, trichomonas, neisseria, gardnerella, E. coli, staphylococci, streptococci, yeasts, etc.
d. Dexpanthenol promotes more intensive restoration of the mucous membrane of the genitourinary tract, normalizes metabolic processes in cells, accelerates mitosis, makes collagen fibers stronger and more resistant to damaging effects, and has an anti-inflammatory effect. It is important that the drug does not affect the functional activity of lactic acid bacteria - representatives of normal human microflora. Depantol has successfully passed a series of clinical trials. One of these studies involved women with injuries to the birth canal. As shown by the results of a clinical trial, the inclusion of Depantol in a complex of therapeutic measures reduced the number of cases of infectious complications. The activity of the drug (though not so pronounced) remains in the presence of abundant exudate. Release form: intravaginal suppositories. Single dose - 1 suppository, frequency of use - 2 times a day, duration of treatment - 7-10 days (if necessary, depending on the clinical situation - up to 20 days). Possible side effects are local allergic reactions that disappear after treatment. Pregnancy and breastfeeding are not contraindications to the use of Depantol. Individual intolerance to chlorhexidine and dexpanthenol is extremely rare.
Depantol - what is the medicine?
Vaginal suppositories Depantol are produced (Russia), this is a combined antiseptic for topical use. The drug contains the following pharmacological substances:
- chlorhexidine bigluconate (chlorhexidine) - antiseptic;
- dexpanthenol - healing agent, vitamin.
Among the additional ingredients, suppositories contain preservatives and substances to give the desired dosage form - macrogol 400 and 1500. The suppositories look like torpedoes, they have a smooth surface and a pointed tip for more comfortable insertion into the vagina.
In addition to this form, Depantol cream is also on sale. It has a similar basic composition, so it can replace candles in its intended purpose. In some cases, applying cream can be more convenient.
Suppositories are torpedo-shaped, white or white with a grayish or yellowish tint. Marbling and the presence of an air core and a funnel-shaped depression on the cut are allowed.
Medicinal properties
Chlorhexidine has pronounced antibacterial properties, due to which it has a detrimental effect on protozoa, fungi and dermatophytes, including chlamydia, staphylococci, ureaplasma, streptococci, and Garnerella. Acid-resistant bacterial flora (Proteus, pseudomonads) is not sensitive to the action of chlorhexidine.
Dexpanthenol is a vitamin belonging to group B. In the body it is converted into pantothenic acid, which is involved in the process of acetylation, fat and carbohydrate metabolism. This substance is actively involved in the synthesis of glucocorticosteroids, as well as acetylcholine and porphyrins. One of the important properties of dexpanthenol is the acceleration of mitosis and stimulation of regenerative processes occurring in the mucous membranes.
The activity of the two active ingredients of the suppositories persists when interacting with blood and pus. Chlorhexidine and dexpanthenol enter the general bloodstream in minimal quantities.
Use during pregnancy and breastfeeding
The drug is allowed to be used during pregnancy in any trimester. The drug is also often prescribed during lactation.
Since Depantol does not penetrate into the blood, it can be used during pregnancy without any fear. In the early postpartum period, the use of the drug is not only not prohibited, but is also recommended in order to accelerate the regeneration of the mucous membrane of the genital tract damaged during childbirth.
Depantol can be used during breastfeeding, as it does not pass into breast milk and does not pose any danger to the baby.
Experts in the field of gynecology say that Depantol suppositories can only be used during pregnancy only under the close supervision of a specialist. If there is hypersensitivity to the composition of the drug and the threat of premature onset of labor, you should stop using the drug.
During lactation, the use of the drug is permitted. There is no need to express milk or stop breastfeeding completely.
Can be used during pregnancy and breastfeeding.
Depantol's analogs
Level 4 ATX code matches:
Hexicon
Citeal
Bepanten Plus
Chlorhexidine Bigluconate
Analogues of suppositories: Betadine, Verno Kit, Ginoflor, Kolposeptin, Osarbon, Furazolidone, Eucolek, Chlorhexidine, Ecovag, Povidin, Macmiror, Klioron, Hexicon, Betadine .
Composition and release form
The drug is presented on the pharmacological market in the following main forms:
- Cream for external use . It has a white tint and is available in aluminum tubes of 30 or 50 g. Each tube is packed in a cardboard box, which contains instructions for use for the drug.
- Vaginal suppositories (suppositories) are white , yellowish or grayish. The suppositories are cone-shaped, making them convenient to insert into the vagina. Suppositories are packaged in blister packs of 5 pieces. One pack may contain 1 or 2 blisters with candles.
Among the main components in the composition of the drug Depantol are: chlorhexidine bigluconate and dexpanthenol. The auxiliary substance in the composition of vaginal suppositories is macrogol 1500 and macrogol 400. Depantol cream additionally contains paraffin petroleum jelly, purified water, cetostearyl alcohol, propylene glycol.
