Hormonal contraceptive "Yarina" - reviews, application features

Birth control pills Yarina Plus have firmly established themselves in the hormonal contraception market.

Yarina Plus is a low-dose (up to 30 mcg), monophasic (the combination of hormones is the same in all active tablets) combined (contains two hormones) contraceptive.

Yarina plus is an analogue of Yarina, with the only exception that the tablets also contain calcium levomefolate.

Read a detailed comparison of Yarina and Yarina Plus.

Compound

• One active tablet of Yarina Plus contains 3 mg of drospirenone , 30 mcg of ethinyl estradiol , 451 mcg of calcium levomefolate . Additional substances: microcrystalline cellulose, lactose monohydrate, hyprolose, croscarmellose sodium, magnesium stearate, orange varnish.
• One vitamin supplement tablet of Yarina Plus contains 451 mcg of calcium levomefolate . Additional substances: microcrystalline cellulose, lactose monohydrate, hyprolose, croscarmellose sodium, magnesium stearate, light orange varnish.

Form and composition

Before moving on to studying reviews of Yarin, it is necessary to list the components that make up the drug, and also talk about what it is.

So, these are small tablets with a diameter of a small pea, which are film-coated. One package contains 21 pieces.

There are only two main components of the component:

• Ethinyl estradiol (30 mcg). It is a synthetic analogue of estradiol. It is aimed at replenishing its deficiency, as well as normalizing metabolic processes occurring in the body. Ethinyl estradiol also helps reduce cholesterol in the body, reduce the amount of dangerous fractions and accelerate the utilization of carbohydrates.
• Drospirenone (3 mg). It is an active contraceptive component. It has antimineralocorticoid and antiandrogenic activity. In structure and components it is very close to progesterone.

In addition, the tablets also contain additional substances. This is titanium dioxide, used as a lightening food additive, as well as talc, corn starch, lactose monohydrate and some other components that are inert from a pharmaceutical point of view.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Monophasic low-dose combined oral estrogen-progestin contraceptive drug, which includes active and auxiliary tablets with calcium levomefolate .

The contraceptive effect of Yarina Plus is carried out by suppressing ovulation and increasing the viscosity of cervical mucus. In patients taking such oral contraceptives, the cycle is normalized, pain, intensity and duration of bleeding are reduced, and as a result, the risk of iron deficiency anemia . There is also evidence of a decreased likelihood of endometrial and ovarian tumors.

Drospirenone exhibits an antimineralocorticoid effect and prevents fluid retention, which can reduce body weight and reduce the risk of peripheral edema. It has antiandrogenic activity and helps relieve acne , reduce oily hair and skin. These facts must be taken into account when choosing a contraceptive for women with hormonal fluid retention, as well as acne .

Calcium levomefolate is an active form of folate that is absorbed better than folic acid . Necessary to meet the increased need for folate during pregnancy and lactation. The presence of calcium levomefolate in the oral contraceptive reduces the likelihood of neural tube defects in the fetus if pregnancy occurs after discontinuation of contraception.

Pharmacokinetics

Drospirenone

After administration it is quickly absorbed. The highest level in the blood is reached after an hour and a half. Bioavailability is 76-85%. Binds to albumin and does not react with hormone binding globulin . Only 3-5% of the substance circulating in the blood is in free form. With systematic use of the drug, the concentration of drospirenone in the blood increases by 2-3 times. Most metabolites are represented by acid derivatives of drospirenone. Excreted through the kidneys and intestines.

Ethinyl estradiol

Rapidly absorbed after oral administration. The maximum level in the blood is reached after an hour and a half. Food reduces bioavailability by 25%. Ethinyl estradiol reacts actively with blood albumin. It is transformed in the liver by aromatic hydroxylation with the production of numerous metabolites. Excreted as metabolic in urine and feces. The half-life reaches 24 hours.

Calcium levomefolate

Rapidly absorbed after entering the digestive tract. In the form of L-5-methyl-THF, it is delivered to organs and peripheral tissues. Folates are involved in the biosynthesis of thymidine, purines, DNA, RNA, methionine and glycine . It is excreted mainly by the kidneys in its original form and in the form of metabolites.

Birth control - a remedy for skin problems

And indeed it is. As mentioned earlier, Yarina birth control pills, reviews of which will be discussed a little later, have an antiandrogenic effect. It manifests itself not only in protection against pregnancy, but also in reducing the symptoms of acne (acne), the risk of seborrhea and sebum production by the skin.

Many people do not understand this action. In fact, everything is logical. Most often, hormonal imbalance causes acne. And the components included in birth control pills help stabilize the sebaceous glands.

The effect is not only long-lasting, but permanent. After all, “Yarina” is a monophasic drug. The level of hormones in the female body remains the same throughout the entire cycle of taking the medication. Accordingly, the imbalance is eliminated, and the girl forgets about skin problems.

Could they appear again? No, if you believe the reviews of women about “Yarin”. The instructions may imply a 7-day break after completing the packaging, but in one week the hormonal balance simply will not have time to be disrupted. However, this time is enough for the concentration of hormones in the girl’s body to decrease, and its cleansing begins, accompanied by menstruation (more precisely, their similarity, called withdrawal bleeding).

Contraindications

Taking the medication is contraindicated if any of the following diseases are present or appear while taking the medication:

• the presence of several or one pronounced risk factor for vascular thrombosis ;
• pre-thrombosis conditions in the past or present;
• thrombosis or thromboembolism in the past or present, cerebrovascular disorders;
• diabetes mellitus with concomitant vascular disorders;
• migraine with focal neurological symptoms in the past or present;
• liver failure or liver disease;
• liver tumors in the past or present;
• decompensated or acute renal failure;
• malignant hormone-dependent tumors or suspicion of their presence;
• lactation;
• pregnancy or possible but not confirmed pregnancy;
• hereditary lactose intolerance lactase or impaired absorption of glucose and galactose ;
• bleeding from the vagina of unknown origin;
• hypersensitivity to the components of the drug.

Take the drug with extreme caution if you have at least one of the following conditions:

• risk factors for thrombosis : obesity , smoking, dyslipoproteinemia, migraine, arterial hypertension , heart valve defects, hereditary thrombosis
• diseases that may cause peripheral circulatory disorders: diabetes mellitus, sickle cell anemia, hemolytic-uremic syndrome, systemic lupus erythematosus, Crohn's disease, phlebitis ;
• hypertriglyceridemia;
• angioedema of a hereditary nature;
• diseases that arose or intensified during pregnancy or against the background of the use of sex hormones ( cholelithiasis , jaundice due to cholestasis , otosclerosis, herpes of pregnant women, porphyria, Sydenham chorea );
• liver diseases not listed as contraindications;
• postpartum period.

Reviews of women over 30 years old about “Yarin”

We can say that the drug in question is universal - it is prescribed to both very young girls and older people.

I would like to consider the comments left by older ladies separately. But we must immediately make a reservation that everything is very individual. What some have encountered is completely unfamiliar to others. So, here is what information can be found in reviews of women over 30 years old about “Yarin”:

• Women who have already given birth and who have been taking pills for several years after the birth of their first child report problems with conception. Contraceptives seem to block the functioning of the ovaries. In young girls, these functions are restored faster, but older women have problems conceiving.
• After childbirth, in women who are initially prone to varicose veins, taking the drug causes discomfort, manifested in unpleasant sensations in the leg. There is a risk of thrombosis. Many people change the drug.
• Women who start taking pills soon after giving birth notice the appearance of spotting that lasts a very long time, as well as regular attacks of dizziness, nausea and bad mood. Plus, skin problems are added to this - unpleasant oiliness and acne.
• Also, many women who started taking Yarina after 30 years of age note in their reviews the appearance of a great desire for food. The appetite practically does not go away, and many are not happy with this, since as a result excess weight and cellulite appear.

There are women who agree with what has been said, and some do not even understand what we are talking about, since the drug suits them. In any case, to avoid undesirable consequences, you should start taking OCs only after they are prescribed by a doctor. And he does this after conducting an examination and carefully studying the tests taken.

Side effects

• Nervous disorders: migraine , headache .
• Mental disorders: changes in libido , depressed mood.
• Circulatory disorders: changes in blood pressure , thromboembolism .
• Respiratory disorders: bronchial asthma .
• Digestive disorders: abdominal pain, nausea, diarrhea , vomiting.
• Skin disorders: erythema multiforme, eczema, acne , rash, itching , erythema nodosum, urticaria .
• Visual disturbances: discomfort when wearing contact lenses.
• Hearing disorders: hypoacusia .
• Reproductive disorders: pain or enlargement of the mammary glands, vaginal candidiasis leucorrhoea , non-cyclic bleeding, changes in the menstrual cycle, vaginitis .
• Other disorders: weight changes, fluid retention, allergic reactions .

Severe side effects of Yarina Plus, which have been reported from people using combined oral contraceptives:

• thromboembolic venous and arterial disorders;
• cerebrovascular disorders;
• increased blood pressure;
• hypertriglyceridemia;
• hyperkalemia;
• impaired glucose tolerance ;
• changes in liver function indicators;
• liver tumors;
• angioedema in persons with a hereditary type of this disease;
• chloasma;
• the appearance or worsening of conditions arising from the use of oral combined contraceptives - jaundice, cholelithiasis, porphyria, herpes of pregnancy , hearing loss, Sydenham's chorea, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn's disease , cervical cancer .

Mechanism of action

The synthetic sex hormones contained in Yarina's drug suppress ovulation, disrupting the maturation of the egg, increase the viscosity of cervical mucus, which prevents the targeted movement of sperm and reduces the risk of infection with sexually transmitted diseases.

Oral medication is recognized as the most effective method of contraception: if used correctly, pregnancy can be prevented in 99% of cases.

Yarina birth control pills are very popular among women of all ages. This medicine is not aggressive. Yarin tablets can be purchased at any pharmacy at an affordable price (within 800-1100 rubles). Taking Yarina has a positive effect on the endocrine, nervous and urinary systems:

• the menstrual cycle is restored;
• the symptoms of premenstrual syndrome decrease;
• the amount of bleeding is reduced;
• the risk of iron deficiency anemia is reduced;
• swelling is eliminated;
• appetite does not increase;
• body weight does not increase;
• the intensity of acne on the skin decreases.

The listed effects are additional advantages of the drug. The main indication for taking Yarina is to prevent unwanted pregnancy.

Only the attending physician can correct hormonal levels using the drug Yarina. Self-administration of systemic contraceptives risks hormonal imbalance and the development of complications.

Instructions for use of Yarina Plus (Method and dosage)

The tablets are taken orally in the order indicated on the package, at the same time every day, with water and without chewing.

Yarina Plus, instructions for use

Reception begins on the first day of the cycle (the first day of menstrual bleeding). Take one tablet per day continuously for 4 weeks. The use of tablets from the next pack begins immediately after the completion of the previous one.

If symptoms of vomiting or diarrhea occur within 5 hours after taking the medication, absorption of the active substance becomes ineffective. In the described case, it is necessary to use additional contraceptive measures.

Yarina Plus is not used during menopause.

The medicine is contraindicated for women with severe renal and liver dysfunction.

How should I take it?

Before we move on to considering the features of Yarina’s action, price, reviews from doctors and girls, it is necessary to list the rules that every woman who decides to start drinking this drug must follow. They can be defined in the following list:

• The first package must be opened on the first day of your period. The day of the week is indicated on the blister under each tablet for convenience. This will help you remember to take the drug.
• You need to take the pills at the same time. If a girl tends to be forgetful, then it is better to set an alarm clock.
• Did you experience diarrhea or vomiting in the next four hours? I need to take a new pill. There is a possibility that not all substances have been absorbed.
• Did the girl still miss her pill? This means that you need to drink it immediately after discovering your mistake. Even if there are several hours left before taking a new one. Or even two at once.
• You must use condoms for the first seven days. It takes time to “activate” the contraceptive effect. Of course, if you believe the reviews of women about the use of Yarina, those who violated the instructions, then this can be neglected. Ladies claim that the tablets begin to act within 1-2 days. Yes, the concentration of hormones increases after just a few hours, but in the first days the body becomes accustomed to the drug.
• If a girl switches to “Yarina” from another oral contraceptive, which contained 28 tablets (“Jess,” for example), then it should be started immediately after completing the pack of the previous OK. In other cases, the same 7-day break is necessary.
• In cases where a woman decides to start taking OK because the hormonal patch or vaginal ring no longer suits her, she must take the first pill on the day when any of the above were removed.
• If before using Yarina the girl took a course of mini-pills (contraceptives containing only gestagen), then you don’t have to wait until the end of the package. You are allowed to stop drinking them any day and immediately switch to taking the contraceptive in question. But additional protection for one week is mandatory. The same applies to cases if a girl switches to this contraceptive from contraceptive implants, injections or an intrauterine device.

These are the basic rules regarding the instructions for use of Yarina. Reviews make sure that this drug never fails and provides reliable protection against pregnancy if taken correctly.

Interaction

The use of drugs that stimulate microsomal liver enzymes can lead to increased excretion of sex hormones. Similar medications include: barbiturates, Phenytoin, Primidone, Carbamazepine, Rifampicin and others.

Some antibiotics ( penicillins and tetracycline ) can reduce the concentration of ethinyl estradiol . During the period of use of drugs acting on microsomal liver enzymes, and another 4 weeks after their discontinuation, you must additionally use a barrier method of contraception.

During the use of antibiotics ( Rifampicin and Griseofulvin do not cause such a need) and for another week after their discontinuation, it is recommended to additionally use a barrier method of contraception.

A number of drugs lower blood folate of calcium levomefolate by blocking the enzyme dihydrofolate reductase ( Trimethoprim, Methotrexate, Triamterene and Sulfasalazine ), reducing folate ( Cholestyramine ) or through unknown mechanisms ( Phenobarbital, Carbamazepine, Primidone, Phenytoin, Valproic acid ).

Folates are capable of changing the pharmacokinetic parameters of antiepileptic drugs , Methotrexate, Pyrimethamine , which is accompanied by a decrease in the therapeutic effect of the latter.

"Yarina" for delay and postponement of menstruation

Surely every girl has experienced this situation in her life: some important event is coming, but the onset of menstruation is also approaching, which is guaranteed to ruin everything.

In such cases, many begin to try various ways to delay or, conversely, early “call” critical days. And the girls who take Yarina are lucky - they may not even consider this a problem, since it is solved in no time.

To prevent your period from coming, you just need to start drinking a new one after finishing the pack, without taking a break. The blocking of ovulation will continue. When the right time comes for menstruation, you can take the prescribed break, and then continue the unfinished pack and then open a new one - so that you get 21 tablets.

Of course, this is not recommended. This is stated in all reviews from doctors. Yarina’s instructions must be followed, but such situations happen, and since there is no other choice, you can ignore it for once.

Some girls do it differently. They decide to start drinking OK spontaneously in order to quickly “block” ovulation before an important event, although menstruation should begin just the other day. This can affect the body even worse. But, since we are talking about reviews of “Yarin”, it should be noted that girls respond positively to the drug - the emergency “delay” works.

special instructions

There is a proven connection between the use of contraceptives of the described type and an increased risk of vascular thrombosis , but these diseases develop rarely. The risk of venous thrombosis is greatest in the first 12 months of taking the drug. The overall likelihood of venous thrombosis in patients using combined low-dose oral contraceptives is approximately 2.5 times higher than in patients not using such drugs. Venous or arterial thrombosis can be life-threatening and cause death in approximately 1% of cases.

Venous thrombosis can manifest as main pulmonary embolism, deep vein thrombosis, and other disorders. Arterial thromboembolism can cause vascular occlusion, stroke or myocardial infarction .

The risk of developing such thrombosis increases:

• in smokers;
• with age;
• with lesions of the heart valves;
• in obese ;
• in the presence of a hereditary or acquired tendency to thrombosis ;
• for dyslipoproteinemia ;
• with prolonged immobilization, surgery, interventions on the lower extremities;
• for migraines ;
• for arterial hypertension ;
• with atrial fibrillation .

An increase in the frequency and severity of migraine may be grounds for immediate discontinuation of this drug.

In very rare cases, when using contraceptives of the described type, the appearance of benign, and even less often, malignant liver tumors .

If severe abdominal pain occurs, liver enlargement, or symptoms of intra-abdominal bleeding, the possibility of a neoplasm should be taken into account during differential diagnosis.

In patients with deteriorating kidney function and elevated levels of potassium in the blood, the possibility of developing hyperkalemia as a result of the use of drugs that lead to a slowdown in the excretion of potassium from the body.

In patients with hypertriglyceridemia, pancreatitis may increase when taking combined contraceptives .

If during the period of use of Yarina Plus a persistent increase in blood pressure is detected, the medicine should be discontinued and therapy for arterial hypertension . It is allowed to continue taking the drug if, thanks to antihypertensive therapy, the blood pressure level has returned to normal.

Liver dysfunction may require discontinuation of Yarin Plus until the corresponding functional indicators return to normal levels. The resulting cholestatic jaundice requires discontinuation of the drug.

Taking folate may mask vitamin B12 .

Taking Yarin Plus can influence the results of a number of laboratory tests: indicators of the adrenal glands, liver, thyroid gland, kidneys, the level of transport proteins, coagulation and fibrinolysis .

The effectiveness of the medicine may be reduced if the tablets are not taken regularly, vomiting or diarrhea due to drug interactions.

While using the drug, discharge or non-cyclic bleeding from the vagina may occur, especially during the first months of taking it. Based on this, evaluation of any non-cyclic bleeding is carried out after completion of the adaptation period, which lasts 3 cycles.

If you do not take the drug regularly and there are no 2 consecutive bleedings during the withdrawal period, pregnancy must be excluded.

Before using the product, it is necessary to collect the patient’s medical history, conduct a general examination, gynecological examination, cytological diagnostics, examination of the cervix, and exclude pregnancy.

About long-term use

Most girls take the same birth control pills for years. And the method itself is simple - high reliability of the contraceptive, ease of use, clear instructions.

In reviews of Yarin, the price is even considered by many to be an advantage of this drug. The cost of one package is about 1,100 rubles at the moment. It's not cheap, but there are contraceptives that cost two, three, or even four times more. "Exluton", for example, costs about 4,000 rubles.

But there are girls who are concerned about the question: is it possible to take birth control for so long? Will they still have the same effect a few years later? Yes, and this is stated in all the doctors’ reviews. "Yarina" is a hormonal drug. It contains no other active substances. The body simply cannot get used to hormones, since these are substances of organic nature.

Moreover, according to WHO recommendations, it is advisable to start taking contraceptives several months after the onset of the first menstruation and continue until the onset of menopause. That is, stop a year after menopause. And take breaks for pregnancy and breastfeeding if a woman is planning children. That is, on average, the duration of taking contraceptives will be about 35 years.

In our country, of course, few people follow this recommendation. But in Europe and the USA, approximately 50% of women use contraceptives. And “Yarina” is one of the most popular OKs there, which has high reliability, and has also stood the test of time and tens of thousands of girls.

True, they are sold there only by prescription. But this excludes unauthorized prescription of drugs. This is why almost no one abroad experiences side effects from taking OCs, since everything is done in accordance with medical recommendations.

Analogs

Level 4 ATC code matches:
Ovidon

Rigevidon

Non-Ovlon

Mercilon

Yarina

Miniziston 20 fem

Novinet

Microgynon

Janine

Lindineth

Cyclo-Proginova

Regulon

Logest

Midiana

Belara

Femoden

Jess Plus

Jess

Zoely

The closest analogue of the described product is a drug called Jazz Plus .

Yarina Plus tablets No. 84

special instructions

If any of the conditions, diseases and risk factors listed below currently exist, the potential risks and expected benefits of using Yarina Plus
in each individual case and discussed with the woman before she decides to start taking this drug. drug.

For disorders of the cardiovascular system

There is epidemiological evidence of an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke) when taking COCs. These diseases are rarely observed.

The risk of developing venous thromboembolism (VTE) is greatest in the first year of taking such drugs. An increased risk is present after initial use of COCs or resumption of use of the same or different COCs (after a dosing interval of 4 weeks or more). Data from a large prospective study involving 3 groups of patients indicate that this increased risk is predominantly present during the first 3 months.

The overall risk of VTE in patients taking low-dose COCs (<50 mcg ethinyl estradiol) is two to three times higher than in non-pregnant patients not taking COCs, although this risk remains lower than the risk of VTE in pregnancy and childbirth

VTE can be fatal (in 1-2% of cases).

VTE, manifested as deep vein thrombosis or pulmonary embolism, can occur with the use of all COCs.

It is extremely rare when using COCs that thrombosis of other blood vessels occurs, for example, hepatic, mesenteric, renal, cerebral veins and arteries or retinal vessels. There is no consensus regarding the relationship between the occurrence of these events and the use of COCs.

Symptoms of deep vein thrombosis (DVT) include the following: unilateral swelling of the lower extremity or along a vein in the lower extremity, pain or discomfort in the lower extremity only when standing or walking, localized warmth in the affected lower extremity, redness or discoloration of the skin of the lower extremity .

Symptoms of pulmonary embolism (PE) include: difficulty or rapid breathing, sudden cough, including coughing up blood, sharp chest pain that may get worse with deep breaths, anxiety, severe dizziness, fast or irregular heartbeat. Some of these symptoms (eg, shortness of breath, cough) are nonspecific and may be misinterpreted as signs of other more or less severe events (eg, respiratory tract infection).

Arterial thromboembolism can lead to stroke, vascular occlusion, or myocardial infarction. Symptoms of a stroke include: sudden weakness or loss of sensation in the face, upper or lower extremities, especially on one side of the body, sudden confusion, problems with speech and understanding, sudden loss of vision on one or both sides, sudden disturbance in gait, dizziness, loss of balance or coordination of movements, sudden, severe or prolonged headache for no apparent reason, loss of consciousness or fainting with or without an epileptic seizure. Other signs of vascular occlusion: sudden pain, swelling and slight blue discoloration of the extremities, acute abdomen.

Symptoms of myocardial infarction include: pain, discomfort, pressure, heaviness, a feeling of squeezing or fullness in the chest, arm or chest, discomfort radiating to the back, cheekbone, larynx, arm, stomach, cold sweat, nausea, vomiting or dizziness, severe weakness, anxiety or shortness of breath, fast or irregular heartbeat. Arterial thromboembolism can be fatal.

In women with a combination of several risk factors or high severity of one of them (for example, complicated heart valve diseases, uncontrolled arterial hypertension, extensive surgical interventions with prolonged immobilization, etc.), the possibility of their mutual reinforcement should be considered. In such cases, the total value of the existing risk factors increases. In this case, taking the drug Yarina Plus

contraindicated (see section Contraindications),

The risk of developing thrombosis (venous and/or arterial) and thromboembolism increases:

- with age,

- in smokers (with increasing number of cigarettes or increasing age, the risk increases, especially in women over 35 years old),

in the presence of:

— obesity (body mass index more than 30 kg/m2),

- family history (for example, venous or arterial thromboembolism ever in close relatives or parents at a relatively young age). In the case of a hereditary or acquired predisposition, the woman should be examined by an appropriate specialist to decide on the possibility of taking the drug Yarina Plus

,

- prolonged immobilization, major surgery, any operation on the lower extremities or major trauma. In these situations, it is advisable to stop using the drug Yarina Plus

(in the case of a planned operation, at least four weeks before it) and do not resume taking it for two weeks after the end of immobilization,

- dyslipoproteinemia,

- arterial hypertension,

- migraine,

- heart valve diseases,

- atrial fibrillation.

The possible role of varicose veins and superficial thrombophlebitis in the development of venous thromboembolism remains controversial.

The increased risk of thromboembolism in the postpartum period should be taken into account. Peripheral circulatory disorders may also occur in diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) and sickle cell anemia.

Increased frequency and severity of migraines while using Yarina Plus

(which may precede cerebrovascular events) may be grounds for immediate discontinuation of this drug.

Biochemical indicators indicating a hereditary or acquired predisposition to venous or arterial thrombosis include the following: resistance to activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C deficiency, protein S deficiency, antibodies to phospholipids (anticardiolipin antibodies, lupus anticoagulant) .

When assessing the risk-benefit ratio, it should be taken into account that adequate treatment of the relevant condition can reduce the associated risk of thrombosis. It should also be taken into account that the risk of thrombosis and thromboembolism during pregnancy is higher than when taking low-dose oral contraceptives (<0.05 mg ethinyl estradiol).

Tumors

The most significant risk factor for developing cervical cancer is persistent human papillomavirus infection. There are reports of a slight increase in the risk of developing cervical cancer with long-term use of COCs. However, the connection with taking COCs has not been proven. The possibility of the relationship of these data with screening for cervical diseases and with characteristics of sexual behavior (less frequent use of barrier methods of contraception) is discussed.

A mega-analysis of 54 epidemiological studies found that there is a slightly increased relative risk of developing breast cancer diagnosed in women currently taking COCs (relative risk 1.24). The increased risk gradually disappears within 10 years of stopping these drugs. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer diagnoses in current or recent COC users is small relative to the overall risk of breast cancer. Its connection with COC use has not been proven. The observed increased risk may be a consequence of careful monitoring and earlier diagnosis of breast cancer in women using COCs. Women who have ever used COCs are diagnosed with earlier stages of breast cancer than women who have never used them.

In rare cases, during the use of COCs, the development of benign, and in extremely rare cases, malignant liver tumors was observed, which in some patients led to life-threatening intra-abdominal bleeding. If severe abdominal pain, liver enlargement, or signs of intra-abdominal bleeding occur, this should be taken into account when making a differential diagnosis.

Other states

Clinical studies have shown no effect of drospirenone on plasma potassium concentrations in patients with mild to moderate renal failure. However, in patients with impaired renal function and an initial potassium concentration at the upper limit of normal, the risk of developing hyperkalemia cannot be excluded while taking medications that lead to potassium retention in the body.

Women with hypertriglyceridemia (or a family history of this condition) may have an increased risk of developing pancreatitis while taking COCs.

Although slight increases in blood pressure have been described in many women taking COCs, clinically significant increases have rarely been observed. However, if while taking Yarina Plus

a persistent, clinically significant increase in blood pressure develops, this drug should be discontinued and treatment of arterial hypertension should be initiated. The drug can be continued if normal LD ​​values ​​are achieved with antihypertensive therapy.

The following conditions have been reported to develop or worsen both during pregnancy and while taking COCs, but their relationship with COC use has not been proven: jaundice and/or pruritus associated with cholestasis, gallstone formation, porphyria, systemic lupus erythematosus , hemolytic-uremic syndrome, Sydenham's chorea, herpes during pregnancy, hearing loss associated with otosclerosis. Cases of Crohn's disease and ulcerative colitis have also been described with the use of COCs.

In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema.

Acute or chronic liver dysfunction may require discontinuation of Yarina Plus

until liver function tests return to normal.
Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous use of sex hormones, requires discontinuation of the drug Yarina Plus
.

Although COCs may have an effect on insulin resistance and glucose tolerance, there is no need to change the therapeutic regimen in diabetic patients using Yarina Plus

. However, women with diabetes should be closely monitored while taking this drug.

Chloasma can sometimes develop, especially in women with a history of chloasma during pregnancy. Women with a tendency to chloasma while taking Yarina Plus

should avoid prolonged exposure to the sun and exposure to ultraviolet radiation.

Folates may mask a vitamin B12 deficiency.

Preclinical data but safety

Preclinical data from routine repeated-dose toxicity, genotoxicity, carcinogenicity and reproductive toxicity studies do not indicate a particular risk to humans. However, it should be remembered that sex hormones can promote the growth of certain hormone-dependent tissues and tumors.

Laboratory tests

Taking the drug Yarina Plus

may affect the results of some laboratory tests, including liver, kidney, thyroid, adrenal function, plasma transport protein concentrations, carbohydrate metabolism parameters, blood coagulation and fibrinolysis parameters.
Changes usually do not go beyond normal values. Drospirenone increases plasma renin activity and aldosterone concentrations, which is associated with its antimineralocorticoid effect. There is a theoretical possibility of increasing the concentration of potassium in the blood plasma in women receiving Yarina Plus
simultaneously with other drugs that can increase the content of potassium in the blood plasma. These drugs include angiotensin II receptor antagonists, potassium-sparing diuretics, and aldosterone antagonists. However, in studies evaluating the interaction of drospirenone with angiotensin-converting enzyme inhibitors (ACI) or indomethacin, there was no significant difference in plasma potassium concentrations compared with placebo.

Reduced efficiency

The effectiveness of the drug Yarina Plus

may be reduced in the following cases: if pills are missed, with gastrointestinal disorders or as a result of drug interactions.

Frequency and severity of menstrual-like bleeding

While taking the drug Yarina Plus

During the first few months, irregular (acyclic) bleeding from the vagina (spotting or breakthrough uterine bleeding) may be observed. You should use hygiene products and continue taking your tablets as usual. Any irregular bleeding should be assessed after an adaptation period of approximately 3 cycles.

If irregular bleeding recurs or develops after previous regular cycles, careful evaluation should be performed to rule out malignancy or pregnancy.

No regular menstrual bleeding

Some women may not develop withdrawal bleeding during a pill-free break. If the drug Yarina Plus

taken as recommended, pregnancy is unlikely.
However, if the drug Yarina Plus
and there are no withdrawal bleedings in a row, the drug cannot be continued until pregnancy is ruled out.

Medical examinations

Before starting or resuming use of the drug, it is necessary to familiarize yourself with the woman’s life history, family history, conduct a thorough physical examination (including measuring blood pressure, heart rate, determining body mass index, examining the mammary glands), gynecological examination, cytological examination of the cervix (Papanicolaou test). ), exclude pregnancy. When resuming taking Yarina Plus

the volume of additional studies and the frequency of follow-up examinations are determined individually, but at least once every 6 months.

It must be borne in mind that the drug Yarina Plus

does not protect against HIV infection and other sexually transmitted diseases!

Conditions requiring medical consultation

- Any changes in health, especially the occurrence of conditions listed in the Contraindications and Precautions sections.

— Local compaction in the mammary gland.

- Concomitant use of other medications (see also Interaction with other medications).

- If prolonged immobility is expected (for example, a cast is applied to the lower limb), hospitalization or surgery is planned (at least 3-4 weeks before the proposed operation).

- Unusually heavy bleeding from the vagina.

- Missed a pill in the first week of taking the pack and had sexual intercourse seven days or less before.

- Absence of regular menstrual-like bleeding two times in a row or suspicion of pregnancy (do not start taking pills from the next package until consulting a doctor).

You should stop taking the tablets and consult your doctor immediately if there are possible signs of thrombosis, myocardial infarction or stroke: unusual cough, unusually severe chest pain radiating to the left arm, sudden shortness of breath, unusual, severe and prolonged headache or migraine attack, partial or complete loss of vision or double vision, slurred speech, sudden changes in hearing, smell or taste, dizziness or fainting, weakness or loss of feeling in any part of the body, severe abdominal pain, severe pain in a lower extremity or sudden swelling of any lower extremities.

Reviews about Yarina Plus

Reviews about Yarina Plus on forums are generally positive. Of the associated effects, the most often noted is the appearance or elimination of acne , deterioration or improvement in the condition of hair and nails. Based on the reports of patients, we can say that unplanned pregnancy does not occur if the rules of administration are followed.

Reviews from doctors focus on the presence of calcium levomefolate , which reduces the likelihood of fetal development defects if pregnancy occurs after discontinuation of Yarina Plus.

How to switch from Yarina to Yarina plus?

If you want to switch from Yarina to Yarina Plus (and vice versa), then it’s easy. Switching from birth control pills alone is possible after the end of the package.

You finish 21 Yarina tablets, take a break for 7 days, and on the eighth day you start drinking Yarina Plus.

ATTENTION! The package of Yarin Plus contains 28 tablets (21 active and 7 vitamin), so there is no break in taking it. As soon as you have taken all 28 tablets, the next day you immediately start drinking a new pack.

Yarina Plus price, where to buy

The price of Yarina Plus in Russian pharmacies averages 890-940 rubles for package No. 28.

In Ukraine, a similar form of release will cost 250-320 hryvnia, depending on the region.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Yarina Plus tablets p.p.o.
  3mg+0.03mg+0.451mg 84 pcs. Bayer Weimar/Bayer Pharma RUB 3,192 order

Pharmacy Dialogue

• Yarina plus (table p/o No. 28x3) Bayer

  RUB 3,193 order

• Yarina plus (tab. No. 28) Bayer

  RUB 1,097 order

Europharm* 4% discount using promo code medside11

• Yarina plus 84 tableBayer Shering Pharma AG

  RUR 3,580 order

• Yarina plus 28 tabBayer Shering Pharma AG

  1350 rub. order

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Pharmacy24

• Yarina plus N28 tablets - 3 packs Promotion of Bayer Pharma AG, Nimecchina/Bayer Weimar GmbH i Co.
  KG, Nimechchyna 631 UAH.order
• Yarina plus No. 28 tablets Bayer Pharma AG, Nimechchina/Bayer Weimar GmbH i Co. KG, Nimechchyna

  261 UAH. order

pharmachologic effect

According to its properties, Yarina’s drug belongs to combination drugs that perform a contraceptive function. The mechanism of its action is to stop the ovulation process, increasing the level of viscosity of the cervical secretion. Taking oral contraceptives helps establish regular menstruation, prevents non-cyclic bleeding, and reduces the risk of ovarian and endometrial cancer.

Yarina Plus helps reduce the profuseness, pain and duration of menstruation. This factor helps reduce the risk of developing anemia. One of the components of the drug is drospirenone, which reduces the likelihood of peripheral edema, fights acne, regulates oily hair and skin, and eliminates seborrhea.

When the substance is used correctly, the Pearl index is very low, but can increase if a dose is missed. Absorption of the substance occurs after 1-2 hours; food does not affect its bioavailability. Metabolism occurs intensively, the concentration of drospirenone inside the blood plasma has two phases of decrease. Decomposition products are excreted by the kidneys and gastrointestinal tract.

The presence of calcium levomefolate (a biologically active form of folic acid) helps to satisfy the need for folates if the patient's medical history indicates their insufficient concentration in the blood plasma. If a woman becomes pregnant immediately after stopping taking the contraceptive, this substance will help reduce the risk of neural tube defects in the unborn child. The component is excreted through the kidneys and intestines.

Drug interactions

Combining Yarina with medications that induce microsomal enzymes increases the clearance of female hormones. The instructions for use indicate that this leads to bleeding and a decrease in contraceptive effect. To avoid pregnancy in this case, it is necessary to use additional methods of contraception. Drugs that reduce the effectiveness of Yarina also include:

• Rifampicin,
• Phenytoin,
• St. John's wort,
• Griseofulvin,
• Topiramate.

Compatibility of Yarina Plus and alcohol

The active components of the drug do not react with alcohol. Therefore, the instructions for use do not include a prohibition on drinking alcohol-containing drinks while taking the contraceptive. According to statistics, when using birth control pills, intoxication occurs faster.

Side effects of Yarina Plus

Medicines containing hormones affect the functioning of vital organs. The drug is not suitable for all women. This is evidenced by the appearance of the following side effects while taking Yarina Plus:

• decreased libido,
• headache,
• blood pressure surges,
• bronchial asthma,
• skin rashes,
• increase in breast volume,
• discharge from the mammary glands,
• thromboembolism,
• mood swings,
• increased sensitivity of the cornea in relation to lenses,
• weight change.

Chest hurts when taking Yarina

While taking oral contraceptives, some women experience increased breast sensitivity and increased volume. Minor discomfort is not considered a pathology. Severe pain is a serious reason to contact a mammologist. To exclude the possibility of pathological formations in the breast, a woman should undergo an ultrasound examination. If necessary, the medication is stopped and a more suitable alternative is selected instead.