Dietary supplement Vneshtorg Pharma Tryptophan Formula of Joy - reviews

The life of a modern person is associated with instability of the emotional state. Against the background of stress, general health worsens and the risk of developing various diseases increases. Russian scientists have created a drug that helps maintain balance in any situation. "Tryptophan Calm Formula" from "Evalar" guarantees a positive attitude and good performance during the day and a restful sleep at night.

Pharmacology

The description of the drug indicates that its use provides the following results:

• There is a balance in the attacks of excitation and inhibition.
• Energy metabolism in the body is maintained in the required state.
• The synthesis of many biologically active substances is normalized - melatonin, serotonin, nicotinic acid.
• The functioning of the endocrine and immune systems improves.
• The risk of developing anemia and blood pressure surges is reduced.
• Antidepressant effect. A person using the drug feels joy and calmness, rather than anxiety and depression. The development of melancholy and various obsessive states is prevented.
• Sleep is normalized and falling asleep improves.
• Helps get rid of withdrawal symptoms.

A special feature is that after consumption the capsule is quickly absorbed from the gastrointestinal tract. The main component predominantly penetrates into the bloodstream in an unbound form. A short time after administration, an increase in the level of neuroactive metabolites (serotonin, melatonin) is observed.

Tryptophan tablets

In some cases, protein-carbohydrate foods are not able to improve the depressed serotonin system. Then doctors prescribe medications of medical importance. Medicines produced by various pharmaceutical manufacturers can restore the required level of essential amino acids in the body. You should not buy the drug yourself, because medical opinions on its use are ambiguous.

Some insist solely on getting the amino acid naturally through food intake. Others claim greater effect from tablet medications. Both sides agree that tryptophan is necessary for the normal functioning of the body, so its ideal ratio is the correct nutritional balance with the parallel intake of dietary supplements containing the amino acid.

For serious pathologies in the body, it is not enough to take a microelement in capsules. Professional consultation with a specialist is necessary so that he can study all aspects of the violation. Only after complex treatment has been prescribed is it possible to support the body using the substance in capsules. Medicines containing amino acids:

• NOW L-Tryptophan 500 mg (USA);
• L-tryptophan, Jarrow Formulas (USA);
• L-TRYPTOPHAN 250 mg Kapseln (Germany);
• Tryptophan 200 mg (Belarus);
• Doctor's Best, Best L-Tryptophan, 500 mg (USA);
• L-TRYPTOPHAN ratiopharm 500 mg Filmtabletten (Germany).

Analogs

Tryptophan has many analogues with a similar principle of action or components:

• Complex 5-HTP 5 hydroxytryptophan. It has the same composition and is available in capsule form. Hydroxytryptophan is used to combat irritability, depression, and has an antidepressant effect.
• Vita Tryptophan. The formula and the result obtained are the same.
• L-Tryptophan. Produced by an American pharmaceutical company. This is a certified complex with the same principle of action and active components.
• Motherwort extract. It can be produced in the form of tablets or herbal mixture for preparing infusions. One of the most popular remedies used for depression and increased nervous excitability.

Tryptophan is classified as a relatively safe drug. But it must be used strictly according to the instructions after a doctor’s prescription.

Advertising:

Which Tryptophan is better on iHerb, description of drugs, instructions for use

Let's look at the supplements recognized by the people as the most popular, according to statistics on the frequency of sales on Iherb.

L-Tryptophan (500 mg) from Now Foods

The drug contains 0.5 grams of free form L-tryptophan.

How to use:

• Every day on an empty stomach you need to drink 2 or 3 times 1 capsule.
• Be sure to take it with water (100 ml).

Take the last portion immediately before bedtime.

Now Foods, L-Tryptophan, 500 mg, 120 Veg Caps RUB 438 View product on iherb

5-Hydroxytryptophan (100 mg), Solgar

Compound:

• 50 mg magnesium (oxide and glycinate);
• 10 mg vitamin B6;
• 100 mg 5-Hydroxytryptophan, obtained from Griffonia seed extract;
• 100 mg valerian root extract.

How to take: for relaxation, 1 capsule during the day on an empty stomach, another to improve the quality of sleep closer to night.

Solgar, 5-HTP, 100 mg, 90 Vegetable Capsules 627 RUR View product on iherb

L-Tryptophan (500 mg) from Source Naturals

Contains:

• 52 mg calcium;
• 1.5g tryptophan;
• 570 mcg iron.

How to drink:

• Daily 3 times x 1 tablet at meal intervals.
• Take with water or juice (100 ml).
• To improve sleep, 1 dose should be taken in the evening.

Source Naturals, L-Tryptophan 500 mg, 120 tablets RUB 1,750 View product on iherb

L-tryptophan with TryptoPure (500 mg) from Doctor's Best

Active ingredient L-tryptophan – 0.5 g.

How to drink:

• 1 capsule daily at night with water.
• Avoid taking the drug together with proteins.

Do not take simultaneously with protein products.

Doctor's Best, L-Tryptophan with TryptoPure, 500 mg, 90 Veggie Caps RUB 1,244 View product on iherb

L-Tryptophan (500 mg) from Jarrow Formulas

The content of the daily portion of L-Tryptophan is 0.5 g.

How to drink:

• Half an hour before bedtime, 1 capsule
• Wash down with ½ glass of juice or water.

Jarrow Formulas, L-Tryptophan, 500 mg, 60 capsules RUB 733 View product on iherb

L-tryptophan, double strength (1000 mg) from Now Foods

Content of L-tryptophan in free form 1 g.

How to use:

• Every day, 1 or 2 times a day, 1 tablet. Another one half an hour before bedtime.
• Only on an empty stomach.

Be sure to drink it.

Now Foods, L-Tryptophan, double strength, 1000 mg, 60 tablets RUB 1,070 View product on iherb

Thorne Research's 5-Hydroxytryptophan

Compound:

• 6.8 mg vitamin B 6;
• 100 mg 5-hydroxytryptophan (5-HTP) from Griffonia simplicifolia seeds.

How to drink:

• 1 capsule 3 times daily. Last time of the day before bed.
• Can be taken directly after meals or on an empty stomach.

Thorne Research, Neurochondria, 90 Vegetarian Capsules RUB 5,545 View product on iherb

L-Tryptophan Powder from Now Foods

In 1 gram of the drug (about ¼ teaspoon) there are 950 mg of free tryptophan. This is the recommended single serving.

How to use:

• 3 or 2 servings daily on an empty stomach.
• Wash the powder down with water or stir it in a glass with 50 ml of juice.
• It is recommended to drink 1 serving before bed.

Now Foods, L-Tryptophan Powder, 2 oz (57 g) $1,200 View product on iherb

L-Tryptophan (500 mg) by Life Extension

The content of the capsule is L-tryptophan 500 mg.

How to use:

• Every day, between meals, 1 to 3 times, 1 pc.
• For better absorption, drink with juice.

Take separately from protein foods and protein supplements.

L-tryptophan (500 mg) from Life Extension RUB 1,614 View product on iherb

L-Tryptophan (1000 mg) from Source Naturals

Composition of the daily serving:

• 20 mg vitamin B6;
• 1 gram of l-tryptophan;
• 390 mcg iron.

How to use:

• 2-3 tablets per day, the last of them before bed.
• Wash it down with juice.

Take on an empty stomach.

Source Naturals, L-Tryptophan, 1000 mg, 90 tablets RUB 2,700 View product on iherb

Life Extension Optimized Tryptophan Plus

How to use:

• 1 to 2 or 3 capsules daily. One or two of them before bed.
• On an empty stomach.
• Wash it down with fruit juice or juice.

It is important to remember: it is not recommended to take dietary supplements with amino acids for more than 3 months in a row. Need to take a break. It is better to coordinate the dosage regimen with your doctor.

The ranking of the best tryptophan supplements is based on customer reviews. Experts' opinions on the best products containing Tryptophan vary significantly.

Life Extension, Optimized Tryptophan Plus, 90 Vegetarian Capsules RUB 1,565 View product on iherb

Comparative table of dietary supplements

Name	Daily dose, tablets/day	Price per package, rub.	Number of tablets per package, pcs.	Price per day of admission, rub.	Flaws	Advantages
Tryptophan from Evalar 125 mg (Russia)	2-4	335/1009	15/60	66/51	High price, need for long-term use	Quick effect, administration, safety
L-tryptophan 500 mg/1000 mg (Now Foods, USA)	2/1	1382/1313	120/60	46/22	You may have problems with bowel movements	Helps well against insomnia, “suppresses” appetite
L-tryptophan 500 mg (Jarrow Formulas, USA)	2	740	60	24	In some cases it leads to indigestion	Demonstrates an excellent effect in the fight against withdrawal symptoms
L-tryptophan 500 mg (Doctor's Best, USA)	1-2	1049	90	24	Does not demonstrate significant results in the fight against insomnia and various addictions	Shown to be effective in losing weight, regulates the functioning of the nervous system well, affordable price, convenient dosage
Targeted Support, Sleep 101, 450 mg (California Gold, USA)	2	1729	60	58	High price	Has a general healing effect on the body, “tightens” the gastrointestinal tract well
L-tryptophan, 500 mg (Source natural, USA)	2-3	908/1755	60/120	30	While taking it, many patients experience hyperexcitability and digestive problems.	Safety, no harmful additives, quickly demonstrates the desired result
L-tryptophan coenzyme B6, 500 mg (Source natural, USA)	2-3	908	60	30	“Heavy” for the digestive tract	Well absorbed, “reanimates” the nervous system
L-tryptophan, 1000 mg (Source natural, USA)	1-2	2380	90	26	Not always well absorbed by the body	Affordable price, economical

Reviews about the application

To leave a review, fill out the special form below:

Leave your review

1 2 3 4 5

Send Cancel

Send your review

Tryptophan

Average rating: Number of reviews: 0

Over 80% of reviews of tryptophan supplements are positive. Patients note that while taking an antidepressant, sleep is normalized, mood improves, strength increases and performance increases. Women say that the dietary supplement relieved them of irritability and PMS symptoms, eased menopause, helped them cope with panic, as well as tachycardia.

Men write in reviews that tryptophan tablets helped them relieve increased irritability, nervous fatigue, and burnout at work. Many consider the amino acid to be a good sports supplement, so they use it to gain muscle mass and also accelerate the synthesis of growth hormone.

But the drug also has disadvantages. Some patients believe that the product did not help them, while others developed side effects or allergies after taking the dietary supplement.

L-tryptophan is safe

Based on data from the FDA (Food and Drug Administration - an agency of the US Department of Health and Human Services), consuming this amino acid as a dietary supplement is absolutely safe.

In 1989, a Japanese tryptophan manufacturer used an unsafe process to purify it, increasing contamination levels. The contaminated batch caused a serious condition known as eosinophilia-myalgia syndrome (EMS). This is a rare autoimmune disease that causes fever, numbness, and a rash. In severe cases it can lead to death.

This has led to FDA restrictions on the import of dietary supplements. In 2001, the FDA relaxed its restrictions because unsafe processes used in the past were identified and stopped. Now, this amino acid is produced in a completely safe way. There is absolutely no harm in consuming it if you follow the instructions on the label.

Symptoms of excess

Nutritionists believe that foods containing tryptophan cannot cause an excess of the amino acid in the body. Even if you take an increased dose at the daily rate, side effects will not appear. However, caution is required because a 1989 study showed that dietary supplements containing tryptophan caused the development of eosinophilia-myalgia syndrome.

This is a systemic disease that affects the skin, circulatory system, internal organs, and even fatal cases are known. With a large amount of Tryptophan in the blood, the following may develop:

• bladder tumor;
• pneumonia;
• neuropathy;
• myocarditis;
• encephalopathy;
• lung damage;
• muscle weakness;
• increased fatigue.

To determine the amount of essential amino acid, laboratory tests of blood and/or urine are needed. Monitoring tryptophan levels will help establish an analysis for the content of 3-hydroxyanthranilic acid. It allows you to detect metabolic abnormalities resulting from poor nutrition and essential amino acid deficiency. If the result is several times higher than normal, this may indicate a bladder tumor.

Why take L-tryptophan

L-tryptophan plays a crucial role in improving mood. It is the body that converts this amino acid into serotonin. It is a neurotransmitter that is known as the “happy hormone.” Tryptophan deficiency can lead to erratic mood swings, severe anxiety disorders, and even depression.

If there is a lack of L-tryptophan in the body, it is taken as a dietary supplement. Many people do not get enough of this amino acid from regular foods.

Symptoms of tryptophan deficiency include:

• depression;
• mood changes;
• sleep disturbance;
• sleep apnea;
• anxiety;
• premenstrual syndrome.

A 2010 study examined the effect of L-tryptophan on the incidence of steatohepatitis, a form of liver disease. The study was based on the formation of oxidative stress and inflammatory reactions. After just four weeks, study participants who took the special supplement every day had improvements in triglyceride levels and available inflammatory cytokines.

In addition, this essential amino acid has a positive effect on irritable bowel syndrome (IBS). The less L-tryptophan in the body, the more severe the symptoms of this condition. Therefore, L-tryptophan is useful in reducing the severity of irritable bowel syndrome.

What is tryptophan

When researching information about healthy sleep, good immunity, mental health or weight loss, you will come across the concept of tryptophan. This is a very important element of life, participating in the biosynthesis of niacin and melatonin (the precursor of serotonin). Tryptophan is an essential protein amino acid that is part of the protein compounds of almost all living organisms.

The only source of element replenishment is food. An essential amino acid can be obtained by microbiological (anthranilic acid and Candida yeast strains), chemical and chemical-enzymatic synthesis. The human body does not synthesize Tryptophan, so it must be replenished regularly through food and dietary supplements.

Tryptophan for a quality workout

For many people, working out is associated not only with the ability to lose weight, but also with finding a good mood. However, often the body’s capabilities do not allow a person to fully engage. Pain, fatigue and discomfort occur.

Scientists studied the effect of tryptophan and derived the following patterns:

• tablets improve physical activity;
• increase endurance;
• increase strength indicators.

As a result, you can increase the duration of your workout due to the absence of severe fatigue. According to average statistical data, the duration of intense exercise increases by 49% under the influence of natural tryptophan.

Indications for the use of dietary supplements with tryptophan

In what difficult situations do doctors recommend taking amino acids:

• In states of stress and depression, often changing emotional mood.
• In cases of constant anxiety, irritability, aggression. With unreasonable fear, obsessive neurosis.
• For disturbances in sleep and wakefulness, insomnia caused by nervous exhaustion.
• In cases of obesity, uncontrolled overeating, eating disorder, as well as uncontrollable craving for sweets.
• With an increased threshold of sensitivity to pain, as well as to get rid of frequent migraines.
• For long flights during travel, to improve adaptation to time zone changes.
• To make it easier to get rid of any type of addiction (alcohol, food, tobacco, gambling).
• For VSD and manifestations of chronic fatigue syndrome.
• Doctors can prescribe tryptophan during periods of severe menopause, as well as during PMS.

It is important to remember: it is not safe to self-medicate, so choosing the best tryptophan supplement should be done in conjunction with your doctor.

Tryptophan to improve sleep quality

Next, we’ll look at how to take Tryptophan for insomnia. Lack of sleep and constant awakenings are the causes of emotional instability and irritability. Elderly people especially suffer from insomnia.

Studies have shown that people who constantly have trouble sleeping feel cravings for refined carbohydrates and fats. Their menu lacks fruits and vegetables. As a result of this eating behavior, obesity occurs.

But for proper sleep, the brain must produce serotonin and melatonin. The substances are synthesized from the amino acid tryptophan, so for those patients who experience sleep problems, taking the drug is useful.

To quickly fall asleep in the evening, it is enough to take from 1 to 15 grams of tryptophan in the evening. However, reviews show that even minimal dosages help normalize sleep and its duration.

Numerous responses from those taking Tryptophan before bed show that in the morning:

• there is a feeling of cheerfulness;
• concentration increases.

Unlike sleeping pills, tablets cause drowsiness, but do not affect mental performance. In addition, the pills do not make it difficult to wake up early in the morning if necessary.

Deficiency symptoms

Experiments on laboratory animals have shown that low Tryptophan content reduces the life of living beings by almost 2 times. A lack of essential acid in the diet can cause:

1. Signs of protein deficiency. Among them:

• general weakness;
• headache;
• character changes;
• swelling;
• slow wound healing;
• weight loss;
• growth disturbance in children;
• hair loss and others.

1. Development of pellagra (a type of vitamin deficiency). It is characterized by the following symptoms:

• dementia;
• diarrhea;
• dermatitis;
• death.

1. Decreased serotonin levels in the blood. In this state the following develops:

• depression;
• overweight;
• poor memory;
• impatience, insomnia;
• irritability;
• impulsiveness;
• inability to concentrate;
• craving for carbohydrates.

You should know that foods with a high amino acid content are especially required by the body during periods of bulimia, anorexia, PMS, seasonal disorders, depression, and headaches. The need for amino acids increases in people with obsessive-compulsive disorder, sleep disorders, schizophrenia, vascular and heart diseases, and increased sensitivity to pain. Provokes a lack of substance:

• excessive consumption of sugar, proteins;
• alcohol abuse;
• smoking;
• diabetes;
• hereditary disorders of tryptophan synthesis;
• defect of the phenylalanine-4-monooxygenase gene;
• hypoglycemia.

Tryptophan, what is it and what is it for, properties of tryptophan

In medicine, tryptophan is used in the complex treatment of depression, sleep disorders, alcohol and drug addiction (the amino acid relieves symptoms of withdrawal symptoms), migraines, neuroses, eating disorders, anxiety and chronic fatigue syndrome. In addition, it allows you to even out the condition of premenstrual syndrome, mood swings, and stressful situations. If there is a lack of tryptophan in the body, performance decreases and the absorption of information deteriorates.

Moreover, unlike traditional antidepressants, tryptophan is not addictive and does not have a narcotic effect.

You can drink tryptophan at any time of the day. In the morning it will help you focus and concentrate on current tasks, and in the evening it will help you fall asleep easily and quickly.

This is due to the fact that serotonin and melatonin are synthesized in our body from tryptophan. At the same time, sunlight is necessary for the synthesis of serotonin. That is, this will only happen during the day. And melatonin, the so-called sleep hormone, is formed from serotonin. But melatonin is synthesized naturally only at night and only in the dark - that is, when you have already gone to bed and turned off the lights. During the day it will not come out of nowhere and will not lead to drowsiness. During the day, serotonin will work, which will give you a clear and positive outlook on the world.

Tryptophan from Evalar

The Russian pharmaceutical company Evalar did not ignore the release of the synthetic drug. It is the country's largest manufacturer of dietary supplements, located in Altai. The raw materials for the products are natural components of animal and mineral origin. Tryptophan is obtained by microbiological synthesis from unicellular microorganisms, fungi and plants. The drug “Formula of Calm” from Evalar is available in capsules of 15, 60, 90 pieces per pack.

Packaging of 60 pieces is very popular, since it is completely enough for a course of treatment. Reviews from doctors about this supplement are mostly positive, since after taking it there is an improvement in the immune system, an increase in the body's production of niacin, and the resistance of the human body is regulated. The use of capsules reduces food cravings, normalizes appetite, reduces anxiety, and relieves depression. Under the influence of serotonin, which is formed after taking L-tryptophan, motivation to continue the diet increases.

pharmachologic effect

The drug from Evalar “Formula of Calm”, according to the manufacturer, will help you remain calm and serene during the day in any situation, and at night you can easily fall asleep and get a good night’s sleep. The drug has a universal effect because it promotes the biosynthesis of melatonin and serotonin in the body. Pharmacological action of the drug during the day:

• maintains emotional stability under increased mental stress;
• lifts the mood;
• increases performance;
• stimulates cognitive activity even in stressful situations;
• eliminates tension, fear, anxiety;
• reduces aggressiveness that arose as a result of giving up bad habits during diets.

• Losing weight with amino acids
• By losing weight, we are killing ourselves - Reduxin, Fluoxetine, Oxitriptan
• Noopept tablets - indications for use for children and adults, composition, side effects, analogues and price

The instructions indicate that by taking the “Formula of Calm” drug, a person will feel increasing self-confidence every day. Cheerfulness and good mood will return to him. How the drug works at night:

• improves the depth and quality of sleep;
• creates mental relaxation;
• helps you fall asleep quickly and easily;
• eliminates the problem of interrupted sleep;
• Helps you get a full night's sleep even in a short time.

Indications for use

Taking the drug “Formula of Calm” reduces the likelihood of exacerbation of many diseases, and in some cases the disease completely recedes. List of indications for prescribing the drug:

• eating disorders accompanied by overeating and extreme hunger (bulimia);
• some types of obesity;
• premenstrual syndrome;
• vegetative-vascular dystonia;
• state of anxiety, psychological disorders of various etiologies;
• irritability, aggressiveness;
• frequent headaches, migraines;
• obsessive states, neuroses;
• fibromyalgia;
• alcohol intoxication;
• nicotine, barbiturate, alcohol addiction (during complex therapy);
• chronic fatigue syndrome;
• depressive disorders;
• panic attacks;
• hyperactivity in a child;
• disruption of the gastrointestinal tract;
• irritability due to weight loss;
• syndrome of complete lack of appetite (anorexia).

Methods of application

How to take Tryptophan is described in detail in the instructions. It contains the following information:

• It is recommended to take the tablets 30 minutes before meals;
• It is possible to take the pills with plain water; juice is also suitable;
• but it is forbidden to combine the medication with milk and other products containing protein.

Only your doctor can tell you how to take Tryptophan for a long time. He will calculate the dosage and frequency of administration. The specialist takes into account the specifics of the disorders, concomitant therapy and the individual characteristics of the patient.

Tryptophan shows great effectiveness in the treatment of psycho-emotional disorders. How much medication to take depends on the severity of the condition and is discussed individually with your doctor. But if necessary, you can repeat the course of therapy several times a year. However, it should be remembered that before starting treatment with this drug, it is necessary to consult a specialist.

Compound

Thanks to its balanced composition, the “Formula of Calm” drug from Evalar has a gentle effect on the human body, rarely causing side effects. One capsule contains 200 mg of the active substance L-tryptophan, 1 mg of vitamin B6 and 2.5 mg of vitamin B5. How the ingredients work:

1. L-tryptophan. Without this amino acid, the body does not produce serotonin, to which a person owes a feeling of happiness, joy, physical and mental performance. It has been proven that in a depressed or prolonged state of depression, the level of serotonin is close to zero. With the onset of night, melatonin is formed from the hormone of joy, which is a regulator of sleep, youth, and longevity. It regulates the phases of night rest and its duration.
2. Vitamin B6 (pyridoxine). Participates in the metabolism of tryptophan, nucleic acids, lipids. Pyridoxine regulates the processes of excitation and inhibition in the central nervous system. Vitamin B6 deficiency leads to loss of the ability to catabolize 3-hydroxykynurenine, which leads to the development of diabetes mellitus.
3. Vitamin B5 (pantothenic acid). Promotes the absorption of amino acids in the intestine, participates in the biosynthesis of many hormones, including melantonin and serotonin, and supports the function of the adrenal cortex.

Instructions

As written in the instructions, capsules with L-tryptophan from Evalar are taken 30 minutes before meals. It is advisable to take the medicine with plenty of plain still water or juice. It is prohibited to use milk or other products containing animal protein for these purposes. The dosage is prescribed by the doctor in each individual case. The average dose indicated in the instructions is 2 capsules/day. To treat insomnia, 2-3 capsules are prescribed, which are taken immediately before bed.

In the combined treatment of drug and alcohol addiction, take 1-4 capsules 3-4 times a day while eating foods rich in carbohydrates, which increase the activity of the essential amino acid. Course duration – 1 month. If necessary, treatment can be repeated 2-3 times a year. If the Formula of Calm drug must be taken simultaneously with other medications, it is recommended that the admissibility of such treatment be agreed upon with a doctor.

Overdose

If the drug is taken uncontrolled, an overdose is possible. If any sign of it appears, you must stop using the drug and consult your doctor to adjust the treatment regimen. Overdose symptoms:

• increased gas formation;
• gastrointestinal disorders;
• migraine;
• vomiting, nausea;
• dizziness;
• serotonin syndrome (mental disorders, convulsions, increased heart rate).

Side effects

The annotation for the drug states that the drug does not exhibit any side effects on the human body. This does not mean that they do not exist at all. In isolated cases, mild disturbances are observed, such as constipation, nausea, flatulence, and drowsiness. Patient reviews indicate other side effects:

• loss of appetite;
• dry mouth;
• heartbeat irregularities;
• decreased blood pressure;
• aggressive state.

Interaction with other drugs

Concomitant use of the drug with medications from the group of MAO inhibitors, selective inhibitors, heterocylic and tricyclic antidepressants can provoke serotonin syndrome, manifested in the form of tremor, hypertonicity, hallucinations, and hyperactivity. These conditions resolve on their own after stopping the drug.

Since, unlike tyrosine, Tryptophan can penetrate into brain cells only with the participation of carbohydrates, the combined use of the Calm Formula drug with blockers of these organic substances is undesirable. Therapy with this medication is prohibited if the patient uses antidepressants whose active substances are:

• paroxetine;
• fluoxetine;
• imipramine;
• sertraline;
• clomipramine;
• tranylcypromine;
• phenelzine;
• amitriptyline.

Contraindications

Since taking the drug may cause drowsiness, it is not recommended to use it when driving vehicles or while working with equipment that is potentially dangerous to life and health. Also, “Formula of Calm” from Evalar is not prescribed during pregnancy and breastfeeding. This is due to insufficient research on people in this category. It is prohibited to drink alcohol during treatment.

Any alcohol-containing drink interferes with the synthesis of melatonin and serotonin and provokes the development of metabolic disorders. The main contraindication to the use of the drug is hypersensitivity to the components of the drug. Constant medical supervision is required for persons suffering from:

• chronic disorders of food digestion;
• cataracts;
• diabetes mellitus;
• bladder cancer.

Analogs

The pharmaceutical market offers many drugs containing tryptophan, similar to the “Formula of Calm” capsules from the company Evalar. Most Popular:

1. Thymogen. An immunomodulatory drug produced in Russia. Available in the form of a solution, cream, spray. 1 ml of solution contains 100 μg of alpha-glutamyl tryptophan. One dose of spray has no more than 25 mcg. 100 g of cream contains 50 mg of active substance. The spray is injected into the nasal passage 2 times a day for 7 days in a row. Intramuscular injections of the drug are prescribed at a dose of 300-1000 mcg/day for no more than 10 days. Cream treatment lasts 20 days.
2. Bestim. Lyophilisate for injection from a Russian manufacturer. Contains sodium gamma-D-glutamyl-tryptophan. Stimulates humoral and cellular immunity. Prescribed to adults in complex therapy for the treatment of immunodeficiency after infectious pathologies, injuries, surgical interventions and other conditions. It is administered intramuscularly at 100 mcg daily 1 time/day for 5 days.
3. L-Tryptophan, Double from the American manufacturer Now Foods. The food supplement “Double Strength” does not contain GMOs and meets international quality standards. Tablets weighing 1000 mg, each package contains 60 pieces. Before being sent for sale, each batch is subjected to microbiological testing. According to the instructions, the drug should be taken 2-3 times a day, 1-2 capsules on an empty stomach or with the last meal before bed.
4. Vita-Tryptophan. Manufacturer Nittany Pharmaceuticals Inc (USA). Indications for use are chronic fatigue, emotional instability, and depression. Do not use the drug for glaucoma or pregnancy. According to the instructions, capsules should be taken 1-2 pieces 2-3 times a day, half an hour before meals.

In addition to direct analogues, medicines with a different composition, but similar in their effects on the body, are sold. It is not recommended to purchase another replacement drug on your own, since all medications have contraindications. The following are considered similar in action:

• Cytoflavin;
• Armadin;
• Keltican;
• Mexidol;
• Mexiprim and others.

Price

Availability of drugs in pharmacies is high. A wide range of medications from different manufacturers are sold without a prescription. Average cost in Moscow and the region:

Name	Manufacturer country	Quantity	Price/rubles
Calm Formula	Russia	275 mg/60 pcs.	1040
L-Tryptophan Powder (powder)	USA	57 gr.	2490
Vita-Tryptophan	USA	50 mg/90 capsules	3060

Compatibility

"Tryptophan" from "Evalar" is a dietary supplement that has an extremely positive effect on the body. If you follow the recommendations of your doctor, the drug cannot cause serious harm. But it inevitably interacts with drugs aimed at combating depression, as a result of which serotonin levels in the brain increase.

The simultaneous use of Tryptophan and antidepressants can cause the following side effects:

• disruption of the cardiovascular system;
• anxiety;
• uncontrollable trembling.

To avoid the occurrence of these conditions, the attending physician must be informed in advance about the medications being taken.

Tryptophan therapy is prohibited if a person uses antidepressants whose active ingredients are:

• fluoxetine;
• paroxetine;
• sertraline;
• amitriptyline;
• clomipramine;
• imipramine;
• phenelzine;
• tranylcypromine

Conditions such as impaired coordination of movements, tremors, temporary loss of self-control and drowsiness may occur while taking Tryptophan with sedatives, the active ingredients of which are:

• clonazepam;
• lorazepam;
• phenobarbital;
• zolpidem;
• dextromethorphan;
• meperidine;
• pentazocine;
• phenothiazine.

It is forbidden to take Tryptophan simultaneously with alcohol. Any alcohol-containing drinks provoke disturbances in all metabolic processes. Alcohol inevitably interferes with the synthesis of serotonin and melatonin.

Impact on the body

The positive effect of “Tryptophan” from “Evalar” both during the day and at night is due to the fact that the drug promotes the synthesis of both serotonin and melatonin. Thus, the tool is universal.

After taking it, normalization of the emotional state is noted:

• the feeling of anxiety and fear recedes;
• the person becomes less irritable, aggressiveness disappears;
• mental activity improves;
• efficiency increases;
• a feeling of harmony and spiritual comfort appears.

At night, insomnia and anxiety subside. Judging by the reviews of Tryptophan from Evalar, the drug helps you fall asleep faster. By ensuring proper rest after waking up, there is a surge of vitality.

Tryptophan or 5-HTP Which is better?

Our bodies naturally convert tryptophan into melatonin and serotonin. Part of the process involves converting it first into 5-hydroxytryptophan, or 5-HTP.

5-HTP is produced in the body, but when used as a supplement, it is obtained from the African shrub Griffonia Simplicifolia. Low levels of serotonin are associated with sleep disturbances, depression, weight gain, and increased anxiety.

5-Hydroxytryptophan (5-HTP) is a byproduct of the amino acid L-tryptophan and a neurotransmitter precursor, used to increase serotonin production, reduce stress, and suppress appetite. Because of this process, many people have a dilemma about which supplement is better to choose.

If taking tryptophan does not have a positive effect on your body, consider using a 5-HTP supplement. 5-HTP acts faster than the amino acid l-tryptophan.

Benefits for the body

The amino acid tryptophan exists in the form of two isomers, but only the L-form has biological activity. This is what is included in dietary supplements and drugs used for medical purposes.

In addition to the fact that tryptophan is needed for the normal reproduction of proteins, it is involved in the production of hormones such as serotonin and melatonin.

The effectiveness of the substance has been proven when used as a sleeping pill and sedative in patients with neuroses. It is also useful to use it in the treatment of other diseases associated with low levels of melatonin and serotonin in the body. The amino acid also has a pronounced antidepressant effect, and in combination with other medications enhances their effect.

Tryptophan is not synthesized in the body, so it is obtained from the outside - from food or dietary supplements. A deficiency of the substance affects the functioning of all systems and worsens well-being, quality of sleep, contributes to the appearance of frequent migraines, fatigue, and the development of digestive problems. In women, with a lack of tryptophan, the skin condition worsens, dermatitis occurs, premenstrual pain, irritability, and tearfulness appear. Nursing mothers with a deficiency of this substance experience a lack of milk.

The benefits and harms of tryptophan

This amino acid is an essential amino acid; without it, the normal functioning of the body is impossible. tryptophan improves mood, has a positive effect on performance and overall appearance of a person (skin and hair condition), and helps to fall asleep quickly. At the same time, an excess of amino acid causes harm to the body, and there is a risk of developing a malignant tumor of the bladder. Excessive intake of this substance threatens the development of serotonin syndrome or overdose. The latter is manifested by dyspepsia, anxiety, and apathy.

Structural formula of tryptophan. Photo: yandex.ru

Contraindications and precautions

Despite the wide range of indications, tryptophan is not suitable for everyone. The supplement is not recommended for use if you have an individual intolerance to this substance, as well as during pregnancy and breastfeeding, unless there are serious reasons. It is undesirable to take amino acids during periods of exacerbation of alcohol or drug intoxication.

Attention! People with bladder cancer, cataracts, diabetes, gastric acid deficiency, or intestinal malabsorption should take tryptophan with caution and only under medical supervision.

Analogue drugs and prices

• Formula of Calm Tryptophan (Evalar, Russia), 15 capsules of 500 mg, 335 rubles (can be ordered online).
• Doctor's Best (USA) – 90 capsules of 500 mg, 1043 rubles (can be purchased on the iherb website).
• Now Foods (USA) – 60 (1000 mg) – 1370 rubles and 120 (500 mg) capsules – 1301 rubles, or tryptophan powder (57 g) – 1164 rubles.
• Source Naturals (USA) – 500 mg capsules, 60 (900 rubles) and 120 (1740 rubles) pieces. This brand also produces tryptophan with coenzyme B6 in tablets - pack of 60 pieces/900 rubles (you can order on iherb).
• California Gold Nutrition (USA) – 60 vegetable capsules, 500 mg each, cost – 857 rubles (can be purchased on the iherb website).
• Jarrow Formulas (USA) – 60 vegetable capsules (500 mg), cost – 698 rubles (available on iherb).

Storage and shelf life of supplements

The instructions indicate that tryptophan-based dietary supplements should be stored in a cool, dark place, away from children. The shelf life depends on the form of release and the manufacturer, but usually does not exceed three years.

Source Naturals, L-Tryptophan, 500 mg, 120 Tablets

★★★★☆
RUB 1,715

Buy More details iherb.com

Description and instructions for the drug Tryptophan

Tryptophan is an amino acid that is involved in many important processes occurring in the human body. As a rule, this substance can be found in various dietary supplements, for example, Reduxin Light Strengthened Formula. Also, some medications may contain tryptophan - for example, Thymogen.

One of the most important characteristics of this substance is that it precedes the synthesis of serotonin, the so-called “hormone of joy.” Further, during biochemical transformations, melatonin, the “sleep hormone,” can be synthesized. Also, tryptophan can activate the immune system. It is these properties that explain the use of this component in drugs and supplements.

Normally, a person gets tryptophan from food. The largest amount of it is found in cheeses, ocean fish, chicken and eggs, turkey, rabbit, legumes, peanuts, and so on.

It should be noted that in meat and fish tryptophan is contained precisely in fat, and not in muscle or connective tissue. This amino acid is low in plant foods

Corn is especially poor in it, which can negatively affect the health of those who eat mainly this product.

Tryptophan is used for:

• Anxiety disorders, phobias, depression and other conditions associated with a lack of serotonin;
• Increased aggression caused by disorders of serotonin metabolism;
• Severe premenstrual syndrome;
• Eating disorders, including bulimia and obesity;
• Headaches and migraines;
• Abstinence from alcohol or drug addiction;
• Sleep disorders;
• Increased fatigue syndrome;
• Pain syndrome;
• The need to support immunity;
• The need to have a general strengthening effect on the body;

Tryptophan is produced, as we have already said, in the form of various drugs with their own trade names. On the territory of the Russian Federation, this substance is registered specifically as a raw material for the production of additives. The instructions for the tryptophan drug, which is packaged in capsules, indicate that they should not be washed down with protein drinks, such as milk. This remedy should be used between meals.

Treatment with tryptophan must be prescribed by a doctor. It determines the dose, frequency of administration, and total duration of the course.

Tryptophan is contraindicated for:

• Combined use with other drugs that affect the nervous system;
• Pregnancy and lactation;
• Hypersensitivity to this substance;

Side effects of Tryptophan

The annotation for this substance does not describe its negative properties. But that doesn't mean they don't exist. The most common, but mild, disorders may be drowsiness, constipation, flatulence, and nausea. But other phenomena are also possible: decreased blood pressure, irregular heartbeat, paradoxical reactions (aggression, insomnia, and so on).

Indications for use

Tryptophan is commonly prescribed to combat low mood, prolonged stress, anxiety, and other nervous system disorders. During stress and depression, the level of serotonin in brain cells decreases, which is why L-tryptophan is used to treat depression. The substance calms, replenishes the reserves of this hormone, increases performance.

Other conditions for which it is advisable to use tryptophan:

• sleep disorder;
• premenstrual syndrome;
• alcohol or drug addiction;
• affective insanity;
• feeling of fear, panic attacks;
• menopause symptoms;
• attention deficit hyperactivity disorder in children;
• eating disorders;
• memory impairment due to psycho-emotional tension.

In healthy people, tryptophan acts as a mild sleeping pill. In patients with mental disorders, the amino acid is used for sleep disorders caused by anxiety and stress. It is also included in the treatment regimen for long-term use of antidepressants, since they cause serotonin deficiency.

In patients with epilepsy, regular intake of tryptophan stabilizes the condition and reduces the frequency and severity of attacks.

Another indication for the use of the substance is poisoning with ethyl alcohol, as well as other narcotic compounds. The nutritional supplement stops stimulation of the nervous system, prevents convulsions and the development of a coma. For women who are breastfeeding, tryptophan can be prescribed as an adjuvant for hypogalactia. But depression in pregnant women is better treated with other drugs.

You can learn about the correct use of tryptophan from the video:

What is tryptophan for?

The amino acid tryptophan is an essential amino acid, that is, one that must be supplied to the body with food. Such substances are not synthesized in the human body. Tryptophan tablets are produced by several pharmacological companies. The package contains L-tryptophan in amounts of 200 mg, 250 mg or 500 mg. The latter dose is often found in dietary supplements - for example, this is the composition of tryptophan from the company Evalar.

What is tryptophan needed for? Photo: tr.eyeni.ru

The amino acid itself is the active component of the drug. In addition to it, Tryptophan contains auxiliary substances - cellulose, glycerin, water, gelatin, calcium and sodium salts. The amino acid exists in 2 isometric forms - L and D. The preparations contain the first form. This ready-made tryptophan is absorbed by the body. In foreign products, the amino acid is contained in the form of 5-hydroxide L-tryptophan (5-htp), which is an intermediate substance in the synthesis of tryptophan and serotonin. The second name of this form is oxytriptan, it is popular in Western Europe, Canada and the USA. Oxitriptan is used to treat migraine headaches, premenstrual syndrome, and eating disorders. Other indications are no different from those of tryptophan itself. The amino acid is involved in protein metabolism. In addition, tryptophan is a component of synthetic reactions - the production of serotonin, melatonin, and choline. Thus, this substance plays a major role in the regulation of cognitive functions, mood, sleep and behavior.

Indications

The body of every person contains an amino acid that plays an important role in the synthesis of proteins and antibodies of the defense system. It's called tryptophan. With a sufficient amount of it, a high level of stress resistance is maintained, fatigue does not bother you, and the organs of the gastrointestinal tract function well.

Tryptophan enters the body with food containing animal proteins. However, it is not enough to maintain a constant level of amino acid. The process of digestion of such products is associated with the formation of substances that suppress the effect of tryptophan. In order for the body to receive the required amount of amino acids, you need to eat meals containing large amounts of complex carbohydrates. But, as a rule, this is not enough. In such cases, doctors recommend the drug Tryptophan from Evalar. Reviews from people who took it are extremely positive: insomnia, chronic fatigue and constant irritability recede in a short time.

Experts note that it is undesirable to ignore the purpose of the drug. A lack of an important amino acid can lead to serious consequences:

• anemia;
• cataracts and other pathologies of the visual system;
• mental disorders;
• deterioration of the condition of teeth, nails, skin and hair;
• pellagra;
• sleep and appetite disturbances;
• delayed physical development in children.

The main indications of Tryptophan from Evalar are:

• constant feeling of anxiety;
• depression;
• aggressiveness towards others;
• irritability during weight loss;
• frequent mood swings;
• disturbances in the gastrointestinal tract;
• seasonal mental disorders;
• pain;
• premenstrual syndrome;
• insomnia;
• bulimia;
• constant feeling of fatigue;
• migraine;
• panic attacks.

In addition, taking the drug improves the condition of vegetative-vascular dystonia. “Tryptophan” from “Evalar” for VSD reduces the likelihood of exacerbations, in some cases the disease completely recedes.

The list of indications for taking the drug can be expanded; they are determined during an individual consultation with the attending physician.

Daily requirement

The norm of a substance for a person is different. It is determined based on health status, age, and the presence of chronic pathologies. Nutritionists say that the daily requirement of the enzyme is approximately 1 g. Doctors recommend calculating the daily dosage using the formula: 4 mg of the substance per 1 kilogram of body weight. Based on these calculations, a 70 kg adult needs to consume approximately 280 mg of L-tryptophan daily.

Both nutritionists and doctors are unanimous in the opinion that it is better to get reserves of essential amino acids from natural products, rather than from drugs created by the pharmaceutical industry. You should know that the protein compound accumulates in the body, so if you do not reach the norm, it will still be replenished from reserves. The maximum permissible dose of Tryptophan, which will not allow side effects to develop, is considered to be 4.5 g/day. If the substance is consumed above the norm, serotonin syndrome (fever, convulsions, delirium, coma) may develop.

Drug interactions

The amino acid, when taken simultaneously with antidepressants (Phenibut, Afobazol, Diazepam, Normotim, Grandaxin), enhances their sedative effect and can cause serious side effects - drowsiness, movement disorders, hyperactivity. The use of L-tryptophan with narcotic drugs (MDMA, Amphetamine, LSD) in most cases leads to the development of serotonin syndrome. Simultaneous use with Tramadol causes an increase in the tone of the muscles of the back of the head, trembling, and confusion.

Attention! Tryptophan, both included in the preparations and in its pure form, is better absorbed with zinc, magnesium, and B vitamins. Thanks to these nutrients, the substance quickly enters the brain and accelerates the production of serotonin.

Is it possible to overdose

If you take the drug uncontrolled, your health may deteriorate.

The main symptoms of overdose are:

• dizziness;
• nausea, vomiting;
• migraine;
• gastrointestinal disorders;
• increased gas formation.

Serotonin syndrome occurs extremely rarely, the signs of which are:

• mental disorders (panic or irrepressible joy, delirium, hallucinations);
• dilated pupils;
• sweating;
• increased heart rate;
• convulsions;
• impaired coordination of movements.

If any sign of overdose appears, the drug is discontinued or the dosage regimen is adjusted by the attending physician.

Side effects

Judging by the reviews, Tryptophan from Evalar is well tolerated by most people. In addition, it does not work the next day after the evening dose.

Side effects from using Tryptophan from Evalar are extremely rare. In isolated cases the following are observed:

• dry mouth;
• loss of appetite;
• drowsiness.

If the doctor has additionally prescribed antidepressants, simultaneous use of the drugs can trigger the occurrence of serotonin syndrome, which disappears soon after.

Amino acid for weight loss

How to take Tryptophan for weight loss is of interest to many women, and even men. To lose those hated pounds, you need to follow a diet. But such experiments are considered a strong burden on the body. Many people break down and start eating everything. In this situation, Tryptophan can help. As a result of therapy, the brain receives the necessary substances and produces the appropriate hormones.

Judging by the reviews, as a result of therapy:

• wild appetite disappears;
• the condition is normalized;
• mood improves.

In addition, the amino acid prevents fatigue from developing, depression and excessive tension.

The main positive property, according to those losing weight, is the rapid onset of satiety when consuming even small portions and reducing cravings for fast carbohydrates.

How to take tryptophan for weight loss:

• Experts recommend using tablets before bed;
• the initial dosage is from 1 to 3 grams of the active ingredient;
• if intensive weight loss is required, then it is possible to double the dosage.

According to doctors, Tryptophan will not cause harm. How long can you take the medicine? The tablets are an amino acid, so they can be taken over a long period of time.

But don't expect an immediate effect. Reviews show that positive effects can be noticed only after two to three weeks of use.

Foods containing tryptophan

If you need to quickly cheer up, drink freshly squeezed berry or fruit juice. They contain many vitamins that promote the production of serotonin. Omega 3 fatty acids, which are present in vegetable oils (flax seeds, olive, sunflower and others), are directly involved in the organization of brain function. Large amounts of L-tryptophan are found in raw seaweed (kelp, spirulina) and greens (spinach, dill, parsley). To produce serotonin, you need to eat fruits and dried fruits (bananas, dates, melon).

How much tryptophan is contained in foods:

Product	mg/100 g	%DV of Tryptophan per 200g serving
Red caviar	960	192
Dutch cheese	780	156
peanut	750	138
soya beans	654	130
almond	630	126
processed cheese	500	100
poultry (chicken, turkey), rabbit	330	66
squid	320	64
sunflower kernels	300	60
chicken	290	58
herring	250	50
salmon	220	44
fat cottage cheese	210	40
chum fish	200	40
chicken eggs	200	40
chocolate	200	40
pork	190	38
low-fat cottage cheese	180	36
buckwheat	180	36
mackerel	160	32
mushrooms	130	26
boiled potatoes	72	14.4
Rye bread	70	14
corn	60	12
cabbage	54	10
bananas	45	9
green onion	42	8,4
kefir, milk	40	8
honey	24	4,8
apples	12	2,4

• Tsitovir for children - instructions for use for treatment and prevention, release form, analogues and price
• Milk for a hangover - the mechanism of action for intoxication of the body, how to drink correctly and useful supplements
• Apilak - instructions for use and composition, indications, release form and cost

How to use

According to the instructions, Tryptophan from Evalar should be consumed half an hour before the intended meal. It is advisable to take the drug with a sufficient amount of still water, or, in its absence, juice. It is prohibited to use milk and other products containing animal protein for this purpose.

Regarding the dosage, it is determined by the attending physician on an individual basis, taking into account the general state of health and the use of other medications. As a rule, it does not exceed 2 capsules per day.

The product is not addictive. If necessary, you can take several courses throughout the year.

Reviews

The remedy has proven itself to be one of the most effective for various types of psycho-emotional disorders. Positive reviews of Tryptophan from Evalar are given by both highly qualified doctors and patients.

People taking the drug note a rapid onset of improvements in their condition: sleep normalizes, aggressiveness and irritability towards other people recedes, and performance increases. They also focus on excellent tolerability of the product. Isolated cases in which side effects occurred were, as a rule, caused by ignoring the doctor’s recommendations regarding dosage and existing contraindications.

Tryptophan for women

Irritability and hot temper are characteristic of women during the premenstrual period. There is a decreased level of serotonin, which causes:

• anxiety;
• overvoltage;
• mood swings.

Standard drug therapy usually involves the use of inhibitors, which causes side effects. If you take an amino acid, it is possible to relieve the unpleasant symptoms of premenstrual syndrome and avoid undesirable consequences.

According to numerous studies, when used by women during premenstrual syndrome, Tryptophan helps reduce pain and mood swings. The usual dosage is 6 grams per day. It is recommended to start taking the pills on the day of ovulation and continue using the drug until the third day of the menstrual cycle.

Reviews from doctors, which tryptophan supplement with iHerb is better

Let's look at what doctors recommend choosing.

Zaitseva N.V. Therapist. MC ON Clinic in Moscow:

In my opinion, the best dietary supplements are those that contain 5-Hydroxytryptophan in combination with vitamin B.

The active ingredients are absorbed faster and the effect of using such drugs is much higher.

I recommend buying 5-hydroxytryptophan (100 mg) from Solgar on Iherb (this is the best patented formula) or, if the drug is not on sale, replacing it with the dietary supplement 5-hydroxytryptophan from Thorne Research.

Fedenko O. Yu. Therapist, St. Petersburg, MC Line:

I consider the best remedy of the above to be the dietary supplement Solgar 5-hydroxytryptophan (100 mg). I'll explain why:

Natural 5-HTP is quickly transformed into serotonin, while L-tryptophan is slowly converted first to 5-htp, only then into the “happiness” hormone. Therefore, the effect of other drugs is reduced and appears later.

5-HTP is not involved in other body processes, which is why serotonin levels increase higher. In addition, it easily passes through the BBB (blood-brain barrier).

In this case, the formation of neurotoxic metabolites does not occur, which means that Solgar preparations have fewer side effects.

Zhilina Yu. V. Nutritionist. Moscow, SM-Clinic:

Tryptophan improves the process of losing weight. In terms of reducing depression and reducing subcutaneous fat tissue, it is more advisable to take dietary supplements with 5-hydroxytryptophan.

One study found an improvement in the effectiveness of taking 5-HTP by 3 times compared to the results of using the active substance L-Tryptophan.

In addition, the depressed mood of women (which plagues them due to excessive obesity) improved much faster in women who took supplements with 5-hydroxytryptophan than in those who used dietary supplements with L-tryptophan.

Judging by the reviews of experts, dietary supplements with active ingredients 5-hydroxytryptophan from Solgar and Thorne Research should be placed at the top of the rating of the best supplements.

Tryptophan Rich Recipes

Liver cake is simply a storehouse of this amino acid. To do this, take 800 g of liver, 2 eggs, 3 carrots and 2 onions, a glass of flour and 200 g of milk. Grind the liver in a blender, add all other ingredients (except vegetables) and bake in vegetable oil in the form of pancakes. Fry the onions and carrots separately. Assemble the cake, sandwiching the pancakes with vegetables and mayonnaise.

Pea zrazy can be a very quick, healthy and tasty dish. To do this, boil a glass of peas, pass it through a blender, add garlic and 2 tablespoons of semolina. Onions and mushrooms are ideal as a filling. Roll the cutlets in breadcrumbs and fry in oil. And buckwheat is suitable as a side dish. As you can see, diversifying your diet with amino acids can be simple and inexpensive.

Daily norm

The body must receive this amino acid in the required quantities, otherwise it will act as a limiting substance. This means that its deficiency can become a factor inhibiting the development of the body. Moreover, the body will take the necessary compound from internal reserves - muscle cells. It is especially important to prevent such developments in adolescents whose bodies have not fully formed. According to most scientists, the daily norm of tryptophan is 0.25 g. Of course, with intense training, this figure will increase.

It is believed that it is better not to consume more than 3-4 grams of amino acid at one time. It is also necessary to take into account the genetic component of the issue. Some people need a little more of this substance for normal protein metabolism, others a little less. To determine how much tryptophan you need, you can use the following formula: 3.5 mg multiplied by body weight.

Price

Tryptophan Evalar costs 320 rubles for 15 capsules. When taking 4 capsules per day, this will only last for 4 days. If taken continuously, you will need 120 capsules per month. This amount corresponds to 8 packs of Tryptophan Evalar.

Therefore, it is better to buy large packages. 60 capsules cost 900 rubles at the pharmacy. Two packs are required per month. The price of a monthly course is 1800 rubles. Typically, sedatives, sleeping pills and antidepressants are more affordable. Other dietary supplements or drugs containing tryptophan are also cheaper.

Reviews from doctors

Anastasia, psychotherapist: “Fragmented, nervous women with personal problems often come to me. I prescribe Tryptophan for them, and after 2-3 visits I notice positive changes, the patients become calmer, more smiling, many are in a better mood, and their family life is improving.”

Victor, somnologist: “I noticed the positive effect of Tryptophan in the treatment of sleep disorders. This relatively inexpensive product quickly helps normalize the process of falling asleep, sleep becomes long and restful, and in the morning patients feel rested and ready for productive work.”

Foods containing amino acids

To increase the content of L-tryptophan, doctors recommend consuming the following foods: fish, oats, bananas, beans, meat of any kind, dairy products, dates.

These products will promote the synthesis of the necessary hormones in sufficient quantities. The main thing is regular use in the diet.

What are the chances of side effects?

The amino acid precursors of serotonin (i.e. 5-HTP) and dopamine (i.e. L-tyrosine) work together during synthesis, metabolism and transport to the extent that they function as one system.
When serotonin and dopamine are properly controlled, they can only be regulated by serotonin, which can be regulated by manipulating dopamine levels. And functions regulated only by dopamine in this balanced state can be regulated by manipulating serotonin. When you have this problem with serotonin or dopamine precursors, you will not get the desired effect from this nootropic. And you increase the likelihood of side effects.

If you add one precursor (i.e. 5-HTP to increase serotonin) that is dominant in another system (i.e. dopamine synthesis), depletion of the dominant system (i.e. depleted dopamine) will occur.

And if this effect is severe enough, you will not benefit from adding the original precursor (i.e. 5-HTP).

A striking example of this effect is the treatment of Parkinson's disease.

Because serotonin and dopamine cannot cross the blood-brain barrier, the amount of serotonin and dopamine molecules in the brain depends on the amount of nutrients (amino acid precursors) that can be synthesized into new neurotransmitter molecules.

Optimizing brain function is a function of high amino acid supplementation. This is a function of achieving the correct balance between serotonin and dopamine.

Tryptophan. Meaning, deficiency, excess and need of tryptophan.

The concept and meaning of tryptophan

Tryptophan is an essential aromatic acid that was isolated from milk casein by scientists F. Hopkins and S. Kohl in 1901.
What is the peculiarity of tryptophan:

• Tryptophan takes part in the production of growth hormone, which triggers the growth of muscle mass. Tryptophan is of greater importance for bodybuilders, as it helps control appetite during the “cutting” period.
• Participates in the synthesis of serum proteins - albumin and globulins, hemoglobin. Maintains nitrogen balance. Strengthens immunity
• Plays an important role in the formation of nicotinic acid (vitamin PP, B3) and the neurotransmitter Serotonin, increases the pain threshold
• In women, it eases the course of premenstrual syndrome
• Reduces food intake (especially carbohydrates), which reduces the risk of obesity (Morris P., et al.,1987)
• Has a hypotensive effect, normalizes blood pressure by dilating blood vessels
• Reduces the toxic effect of ethanol
• Increases the content of melanin pigment in the skin - the effect of 3-hydroxykynurein and niacin, which reduces the risk of developing vitiligo (Costa C. et al., 1981)

In the intestine, skatole is formed from Tryptophan, and from it indole -> indican -> indigo (blue)

Tryptophan is a precursor to Serotonin and increases its level, so it is used to treat depression and anxiety, and insomnia. It is considered one of the best antidepressants.

Tryptophan deficiency leads to:

• children's growth retardation
• anemia,
• protein deficiency
• hair loss,
• fatty liver degeneration,
• degeneration of seminiferous tubules and smooth muscles,
• suppression of lactation,
• infertility

Tryptophan deficiency is characterized by:

• fatigue, decreased performance, irritability, poor concentration, constant headaches, unstable and shallow sleep
• disorders of the cardiovascular system, spasms of the coronary arteries
• tendency to overeat and/or “carbohydrate cravings”

Serotonin is called the “hormone of happiness”, since its safely high concentration gives a person a good mood and a state close to euphoria. If the level of the neurotransmitter serotonin decreases, a person feels depressed, apathetic and tired.

Serotonin deficiency plays a critical role in aggressive and impulsive behavior.

In older adults, decreased tryptophan levels increase the risk of cataracts.

Increased serotonin synthesis can lead to niacin and tryptophan deficiency

Tryptophan requirement

Thus, the need for tryptophan, according to most authors, exceeds the modern “adequate level of consumption”

Digestion: 85-100% (wheat porridge - 73%, beans - 59%) (Mc Donough FE et al., 1989)

NEED:

• Calculation formula: 3.5-4.0 mg multiplied by body weight = 245-280 mg/day
• 50 mg/kg (350 mg) (Allegri g. et al., 1978)

The MAXIMUM ALLOWABLE SAFE DOSE of TRYPTOPHAN that does not cause side effects is considered to be 4.5 grams per day.

Excess tryptophan:

Excess tryptophan is a fairly rare occurrence, but there are a number of diseases that are accompanied by the accumulation of tryptophan:

1. Familial hypertryptophanemia (joint pain, visual impairment, developmental delay),
2. TADA syndrome, which leads to dwarfism (tryptophan is not converted to kynurenine and then to niacene),
3. Price's syndrome – excess production of kynurenine (kynurenine hydroxylase defect)
4. Serotonin syndrome: excess Serotonin makes itself felt very quickly - within a few hours. Excessive emotional arousal is commonly observed and can manifest itself in a variety of ways. A person will react very violently to any change, and the expression of emotions can be extremely strange, for example, a continuous stream of words. A person may experience hallucinations, spontaneous panic, a state of fear and anxiety. A person is frightened by any incomprehensible things, and there is a feeling of impending danger and imminent death. If such an attack drags on, attempts may occur to harm yourself in order to get rid of fear. Looking at a person in such a state, we can say that he is “rushing about”, not finding a place for himself.

Tryptophan should be taken with caution by people suffering from diabetes, cataracts, and achlorhydria.

Symptoms of tryptophan overdose : vomiting, dizziness, diarrhea, flatulence. Rarely, serotonic syndrome (delirium, convulsions, high body temperature) occurs.

High levels of tryptophan can cause fatigue and difficulty breathing in people with asthma.

Action of serotonin on the central nervous system

Serotonin is a neurotransmitter called the “happy hormone” that helps regulate appetite, sleep, and mood.

Serotonin causes relaxation and creates a feeling of emotional well-being. People who are depressed have low amounts of both serotonin and tryptophan in their blood. Their low content in the body causes depression, anxiety, insomnia, attention disorders, hyperactivity, headaches, tension

• Can help even with severe depression and chronic insomnia. In such cases, the dosage of Tryptophan is high and reaches 3 g.
• It is known that bad mood, depression and anger are often the result of a lack of serotonin, and therefore Tryptophan, the deficiency of which can affect facial expressions, causing an angry expression on the face
• Prescribing 100 mg of Tryptophan three times a day changes behavior, making people more compliant, and the desire for quarrelsomeness decreases.
• It is believed that the aggressiveness of the Indians of South America - the Mayans and Aztecs - could be associated with the predominance of corn in their diet, which is low in Tryptophan.
• Tryptophan deficiency in the diet of rats makes them more aggressive (Giamanco S. et al., 1989)
• 500 mg Tryptophan helps relieve aggression in adolescents
• Alcohol reduces the content of Serotonin in the BRAIN, which manifests itself in anxiety, depression or aggression, which is characteristic of alcoholism (Badawy A.-B., 1988)
• The level of Serotonin in the body is minimal in February and September (Wirz-Justice A. et al., 1977)

TRYPTOPHAN exhibits its effect through the formation of an intermediate metabolite - 5-HYDROXYTRYPTOPHANE. It must be taken into account that most of the Tryptophan ingested from food is degraded through the formation of kynurenine and only a small part of it is metabolized through other pathways (!!!), including the formation of SEROTONIN and MELATONIN (Meister, 1965; Leklem, 1971)

The effect of tryptophan on sleep

Improved sleep under the influence of TRYPTOPHAN is associated with the production of the sleep hormone MELATONIN, which is formed from serotonin.

One of the main actions of MELATONIN is the regulation of sleep. In a person leading a diurnal lifestyle, the secretion of MELATONIN by the pineal gland coincides with the usual hours of sleep. In a person with normal sleep at night, the night hours account for 70% of the daily production of MELATONIN.

With age, the activity of the pineal gland decreases, the amount of MELATONIN decreases, sleep becomes superficial and restless, and insomnia is possible. MELATONIN helps eliminate insomnia and stabilizes daily biorhythms***. Sleep becomes deep, which relieves fatigue and irritability. During calm, deep sleep, the functioning of all organs and systems in the body is normalized, muscles relax, and the brain rests.

Tryptophan to normalize sleep

To correct sleep, it is enough to take 15-20 g of TRYPTOPHAN at night. To completely get rid of alarming symptoms, a long course (250 mg/day) is required.

Yes, TRYPTOPHAN provokes drowsiness. However, compared to sedatives, it does not depress mental activity.

In the 1970s, it was believed that TRYPTOPHAN, taken in a dose of 1-5 grams, helps improve sleep quality. But then it was found that 250 mg of this amino acid is enough to enter the stage of deep sleep.

Further studies showed that 1 g of TRYPTOPHAN helps to effectively fight

With insomnia, significantly shortens the time to fall asleep, reducing wakefulness in the evening.

TRYPTOPHAN is a natural sleeping pill. There is a lot of it in milk. Milk taken at night improves sleep.

Tryptophan and pellagra (vitaminosis)?

TRYPTOPHAN is a precursor of vitamin B3 NIACIN (nicotinic acid, PP). NIACIN deficiency causes RELLAGRA (dermatitis, diarrhea, dementia).

NIACIN is a component of the coenzymes NAD and NADP.

IN THE human LIVER, NIACIN (one of 60 tryptophan molecules) is synthesized from 3% TRYPTOPHAN.

The tryptophan content in natural sources varies (in corn there is little tryptophan. Where corn is the main source of nutrition, the risk of developing pellagra is increased).

Tryptophan content in diet

Tryptophan content in protein and other food products, mg/100 g:

1. Human milk - 1.9 mg
2. Cow's milk – 1.6
3. Chicken egg – 1, mg
4. Meat – 1.2 mg
5. Fish – 0.8 mg
6. Oatmeal – 1.3 mg
7. Wheat flour – 1.3 mg
8. Legumes – 1.3 mg
9. Potatoes – 0.6 mg
10. Roquefort cheese – 900 mg
11. Swiss cheese – 1000 mg
12. Sunflower seeds - 337 / 340 mg
13. Red caviar – 380 mg
14. Turkey meat - 330 mg
15. Squid, chicken, rabbit, liver - 300 / 260 mg
16. Cheddar cheese – 735 mg
17. Beef stew – 290 mg
18. Poshekhonsky cheese – 700 mg

The supply of tryptophan to the brain decreases with excess protein intake from food! (Grayton JW, 2001). For this reason, it is preferable to use 5-hydroxytryptophan

How can you replenish tryptophan and serotonin?

5 HTP Power (5-HTP-Power ) or 5-Hydroxytryptophan is a metabolite of the amino acid tryptophan and a precursor of not only the neurotransmitter serotonin, but also the hormone melatonin.

The purpose of “ 5-HTP Power ” solves several problems at once:

• Calming and antidepressant effect - due to the formation of the neurotransmitter serotonin
• Improves sleep (fights insomnia) – due to the formation of the hormone melotonin.
• Antispasmodic (relieves pain), lowers blood pressure and improves blood flow
• Improves the body's condition during menstruation, seasonal emotional disorders, neuroses, obsessive disorders, drug and alcohol addictions
• Suppressing bulimia and reducing appetite, which is important in weight loss programs
• Reducing the state of fear, anxiety, excitement, tension, irritation, aggressiveness
• Improves brain function, memory, attention, increases learning ability

In all these cases, the administration of 5-hydroxytryptophan (a metabolite of tryptophan) is preferable to the administration of the amino acid tryptophan itself.

Dosage: for an adult, 1x1 time per day, with meals, for 3-4 weeks.

You need to understand that for the formation of serotonin from tryptophan you need: Vitamins C and, as well as Magnesium.

For effective health care, it is necessary to choose products according to the clinical situation and individually select the optimal dosage and duration of use

NSP also has other neurotropic products that have an extremely broad spectrum of action:

Eight (Eight) - is a complex of 8 plants (White willow, cayenne pepper, ginger, cohosh, capitol, fragrant martinia), complementing and enhancing the effect of each other. HARMONIZES the functioning of the nervous system.

• Calming effect on anxiety, insomnia, depression, neurosis
• Regulates the state of the nervous system
• Eliminates vegetative-vascular disorders
• Reduces symptoms and balances disturbances in premenopausal and menopausal women

Dosage: Adults take 1 capsule 3 times daily with meals for 2-3 weeks.

Complex with valerian (HVP) is a complex of three herbal remedies (valerine, hops, passionflower)

1. Calms and calms, thereby balancing the work of the autonomic and central nervous systems
2. Hypnotic effect (relaxes, relieves nervous tension and agitation, normalizes sleep)
3. The product thanks to a well-selected collection of herbs in a complex that eliminates tearfulness, hypertension, irritation, and pain symptoms

Dosage: 1 capsule 2 times a day with meals.

Mind-Max is a complex of three herbal remedies (Gotu Kola, Bacopa parvifolia, Ginkgo biloba and magnesium)

1. Increases the ability to cognition, memorization, concentration, thereby preventing attention, strengthens the processes in the brain, stimulating mental activity.
2. Recommended for diseases of the central nervous system, thereby preventing the development of neuroses, neuralgia, amnesia, migraines, Alzheimer's disease, Parkinson's and as rehabilitation after a post-stroke condition, etc.

Dosage: 3 capsules 2 times a day with meals.

Recommendations from candidate of medical sciences Lysikov Yu.A.

Reviews of those losing weight

Svetlana, 36 years old, Voronezh: “I took an amino acid while losing weight to reduce cravings for sweets. I ordered it from iHerb in a dosage of 500 mg. At first I took the capsules late in the evening. But then I had to reschedule the appointment to the morning, because... sleep became restless. I took the medicine on an empty stomach. The effect appeared after a few days. The craving for sweets has disappeared.”

Anna, 28 years old, Saratov: “I use Vita-Tryptophan during diets to control my appetite. After only 3-4 days I begin to calmly look at foods and eat only when I feel hungry. The product also has a drawback. After 3 weeks of taking it, it stops working. Appetite stops decreasing. I have to stop taking it for a while.”

Dairy

And we are no longer talking about milk, but about its derivatives, fermented milk products. When considering which products contain the amino acid tryptophan, first place should be given to natural hard cheese. 100 g contains 790 mg of this useful substance. There is less of it in processed cheeses, approximately 500 mg. Milk, kefir and cottage cheese each contain approximately 210 mg. A tasty and healthy breakfast of grain bread with cheese can provide half of the daily requirement, and in the evening supplement the menu with kefir.

Content

• 1 Biosynthesis
• 2 Catabolism
• 3 Metabolites
• 4 Methods of obtaining and production of tryptophan 4.1 Chemical synthesis
• 4.2 Chemical-enzymatic synthesis
• 4.3 Microbiological synthesis

5 Food Sources of Tryptophan

5.1 Table of tryptophan content in foods

6 Metabolic disorders

6.1 Familial hypertryptophanemia

6.2 Hartnap disease

6.3 Thad syndrome

6.4 Price syndrome

6.5 Indicanuria

7 Tryptophan and eosinophilia-myalgia syndrome

8 Tryptophan and the immune system

9 Tryptophan and life expectancy

10 Tryptophan and drowsiness

11 Fluorescence

12 Tryptophan analogues

13 Application

14 Notes

Tryptophan and eosinophilia-myalgia syndrome

In the late 1980s, a very large number of cases of eosinophilia–myalgia syndrome were observed in the United States and some other countries. This problem became public in 1989, after the personal doctors of three American women, having discussed the situation among themselves, raised the alarm. The size of that outbreak was subsequently estimated to be approximately 60,000 cases, of which approximately 1,500 were disabling and at least 27 were fatal.

It was found that almost all patients took L-tryptophan from the Japanese manufacturer Showa Denko. This tryptophan was produced using a new specially developed strain of genetically modified microorganisms. During the investigation, samples of the drug were taken from several batches of tryptophan. More than 60 different impurities were identified in these samples. These impurities, among which EBT (1,1′-ethylidene-bis-L-tryptophan) and MTCA (1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid) turned out to be especially suspicious, have been thoroughly studied, but none of them have been shown to cause such serious health problems as eosinophilia-myalgia syndrome.

The possibility was also considered that eosinophilia-myalgia syndrome could be caused by L-tryptophan itself when it is in excess of the body. Experts have tried to evaluate the possibility that tryptophan metabolites may inhibit histamine degradation and that excess histamine may contribute to inflammatory processes and the development of eosinophilia-myalgia syndrome. Despite all the efforts made, it has not been possible to reliably establish what exactly caused eosinophilia-myalgia in people taking tryptophan.

Increased control of tryptophan, including a ban on imported tryptophan, has led to a sharp decrease in the incidence of eosinophilia-myalgia syndrome.
In 1991, the United States banned most tryptophan from sale, and other countries followed suit. In February 2001, the FDA relaxed the restrictions, but still expressed concern: “Based on the scientific evidence that is available at the present time, we cannot determine with certainty that the occurrence of EMS in susceptible persons consuming L-tryptophan supplements derives from the content of L-tryptophan, an impurity contained in the L-tryptophan, or a combination of the two in association with other, as yet unknown, external factors.”
[13]

Translation:
“Based on the scientific evidence we currently have, we cannot answer with certainty what causes eosinophilia-myalgia in susceptible individuals who consume L-tryptophan. We cannot say whether L-tryptophan itself, or an impurity contained in L-tryptophan, or a combination of L-tryptophan, impurities with other, as yet unknown factors, is capable of causing eosinophilia-myalgia.”

Contraindications

• The use of the drug is unacceptable during pregnancy; if this is the period of lactation, it is advisable to stop breastfeeding.
• Do not use if you are sensitive to the drug.
• Also stop taking it if increased drowsiness occurs after the drug.

The instructions for L-tryptophan indicate that use simultaneously with other drugs, as well as indications and contraindications, should be discussed with your doctor.

• The best amino acids - application features and options for using the most effective amino acids for athletes (95 photos)

• Arginine in products - tips on use, benefits, harms, indications and contraindications for the use of amino acids

• Fat burner for women: main methods of administration and tips on how to choose sports nutrition for weight loss (125 photos and videos)

Tryptophan - analogues

The main analogue of tryptophan in Russia is Thymogen (Alpha-glutamyl-tryptophan) nasal spray. The cost of Thymogen spray in pharmacies is around 300-400 rubles.

Also have similar actions:

• Lysine
• Cytoflavin
• Mexidol
• Kaltikan
• Armadin
• Mexiprim

Tryptophan and other products

Vitamin B6, vitamin C, folic acid and magnesium are essential for tryptophan metabolism. In addition, tyrosine and phenylalanine are competitors of tryptophan.

Because of this, some medical professionals believe that consuming foods rich in tryptophan does not increase blood levels sufficiently to produce a therapeutic effect , and therefore tryptophan supplements should be taken to increase blood levels.

Capsules 5 htp 100 mg optimal dose

The recommended dose of 5-HTP if you are going to try it is 50 mg 1 – 3 times a day.
Some studies have used higher doses than our recommended dose, but 5-HTP can be toxic at high doses.

For anxiety or depression, 5-HTP is dosed at 150 – 300 mg per day.

To relieve depression after MDMA (ecstasy), 5-HTP 100 mg per day 3-7 after MDMA use.

Successful 5-HTP supplementation requires a dopamine precursor such as L-tyrosine or L-DOPA along with B-vitamins (for synthesis) and one of the sulfur-containing amino acids (methionine, cysteine, homocysteine ​​or taurine).

And you have to watch how this stack is placed on your body. If you start to experience any side effects, it is a good sign that serotonin or dopamine is out of balance.

DO NOT combine 5-HTP with any antidepressants.

Combining SSRIs, tricyclics, or MAOIs with 5-HTP will cause serotonin syndrome. An extremely dangerous condition involving severe mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma.

Serotonin syndrome can kill you. And we're not kidding here.

What foods contain tryptophan?

This substance is not produced by the body and enters it only through food or when taking drugs of the same name.

Foods containing tryptophan:

• Nuts: pistachios, almonds, cashews, peanuts, sunflower seeds, pine nuts. • Legumes: beans, peas, soybeans, lentils. • Cereals: pearl barley, oatmeal, buckwheat, wheat, barley. • Dairy products: milk, kefir, yogurt, sour cream, processed and hard cheeses, low-fat cottage cheese. • Seafood: mackerel, sea bass, black and red caviar, mackerel, squid, salmon, pollock. • Meat products: pork, beef, chicken, turkey, veal, lamb, beef liver. • Other products: eggs, dried apricots, pasta, mushrooms, wheat bread, halva, fried or boiled potatoes.

There is tryptophan in some fruits, vegetables and berries, but in much smaller quantities: grapefruit, peach, cherry, zucchini, watermelon, tomato, bananas, cabbage, melon, persimmon, strawberries. By monitoring the quality of your diet, you can saturate your body with essential amino acids and tryptophan in particular.

Fluorescence

Tryptophan has the strongest fluorescence of all 20 proteinogenic amino acids. Tryptophan absorbs electromagnetic radiation with a wavelength of 280 nm (maximum) and emits solvatochromically in the range of 300-350 nm. The molecular environment of tryptophan influences its fluorescence. This effect has implications for the study of proteins. The interaction of the indole core with the nitrogenous bases of nucleic acids leads to a decrease in fluorescence intensity, which makes it possible to establish the role of this amino acid in protein-nucleic acid interactions.

Excess tryptophan in the body. Amino acid overdose

It must be said that an excess of tryptophan in the body is a rather rare occurrence, but there are several diseases that are accompanied by the accumulation of this amino acid. In this regard, it is necessary to mention familial hypertryptophanemia, which occurs due to metabolic disorders. Its consequences are sad: joint pain, visual impairment, developmental delays. Also worth mentioning is Thad syndrome, which most often leads to dwarfism. This disorder occurs when tryptophan is not converted to kynurenine.

Tryptophan should be taken with caution by people who suffer from diabetes, cataracts, and achlorhydria. It is also necessary to name the symptoms of an amino acid overdose: vomiting, dizziness, diarrhea, flatulence. In rare cases, serotonic syndrome occurs, accompanied by agitation, anxiety, and lacrimation.

Biosynthesis

Tryptophan is synthesized in nature via anthranilate. In the process of anthranilate biosynthesis, intermediate compounds are shikimate and chorismate. The biosynthesis of anthranilate is discussed in the article via the shikimate pathway. Four reversible reactions constitute the shortest route to convert anthranilate to tryptophan. The genes responsible for these reactions, as well as for the irreversible reaction of anthranilate formation from chorismate, are called trp

-genes in bacteria are also combined into the tryptophan operon.

Schematic structure of the tryptophan operon in Escherichia coli

can be expressed by writing:

—trp

R—…—Promoter—Operator—Leader—Attenuator—
trp
E—
trp
D—
trp
C—
trp
B—
trp
A—Terminator—Terminator—

Stages of the biosynthetic process chorismate →→ tryptophan:

1. Anthranilate is synthesized from chorismate. The donor of the amino group is the amide nitrogen of glutamine or ammonium. The reaction also produces pyruvate. In Escherichia coli,
   the reaction is carried out by component I of anthranilate synthase, a product of the
   trp
   E
2. Anthranilate is phosphoribosylated by phosphoribosyl pyrophosphate to form phosphoribosylanthranilate. The reaction releases inorganic pyrophosphate (in the presence of pyrophosphatase, the reaction is almost irreversible). In Escherichia coli,
   the reaction is carried out by component II of anthranilate synthase, a product of the
   trp
   D
3. Phosphoribosylanthranilate undergoes an Amadori rearrangement and isomerizes to phosphoribulosylanthranilate. In Escherichia coli,
   the reaction is determined by the phosphoribosylanthranilate isomerase activity of indole glycerol phosphate synthase, which is a product of the
   trp
   C
4. Cyclization of phosphoribulosilanthranilate, accompanied by decarboxylation-dehydration, leads to indole-glycerol phosphate. In Escherichia coli,
   the reaction is determined by the activity of indole glycerol phosphate synthase, a product of the
   trp
   C
5. The substituent is cleaved off in the form of glyceraldehyde-3-phosphate, and this substituent is replaced by another three-carbon substituent originating from the L-serine molecule. The reaction proceeds through the intermediate formation of unsubstituted indole. The reaction is pyridoxal dependent. In Escherichia coli,
   the reaction is carried out by tryptophan synthase of subunit composition
   α2β2
   (subunit
   α
   is the product of the
   trp
   A gene, subunit
   β
   is the product of the
   trp
   B gene)[2].

In nature, tryptophan is synthesized by microorganisms, plants and fungi. Multicellular animals are unable to synthesize tryptophan de novo

.
For humans, as for all Metazoa
, tryptophan is an essential amino acid and must be supplied to the body in sufficient quantities with dietary proteins.

pharmachologic effect

Tryptophan is called the calm formula. The dietary supplement contains ingredients that help improve mood, increase efficiency, and deep, restful sleep.

Pharmacodynamics

The amino acid tryptophan promotes the synthesis of melatonin, serotonin, and the hormone of pleasure in the body. It plays an important role in the production of proteins and antibodies of the defense system. Thanks to these processes, people’s levels of aggression and anxiety decrease, their mood improves without the use of alcohol and drugs, appetite is normalized, digestion and sleep improve.

Dietary supplements are often prescribed to relieve withdrawal symptoms and to treat alcohol and nicotine addiction. It is effective in combating depression.

Pharmacokinetics

The drug is quickly absorbed from the gastrointestinal tract, resulting in an increase in the level of serotonin, melatonin and other neuroactive metabolites in the body.

The drug is quickly absorbed from the gastrointestinal tract.

Unique properties. The importance of amino acids for the body

As we said above, tryptophan is an essential amino acid that cannot be produced by the body. Its regular intake with food is especially important given the importance of the amino acid for the body. This substance plays a huge role in the functioning of the endocrine and nervous systems. In particular, it is necessary for such an important physiological process as sleep.

In addition, it is important for relaxation and rest, which means that with its help we will always look good. Tryptophan can be called a natural antidepressant, thanks to it we feel calm and harmonious. Why? It's simple: it is responsible for the production of many substances important for the body in the brain. Firstly, it is niacin (vitamin B3). Secondly, serotonin, the most important neurotransmitter, which is called the “happiness hormone”. It is the main fighter against depression in our body and creates a feeling of emotional well-being.

It is important that tryptophan is also necessary for the formation of melatonin. Melatonin helps you fall asleep quickly and stay asleep longer. By the way, serotonin is produced during the daytime, and melatonin is produced at night. This amino acid is also necessary for the production of: kynurenine, quinolinic acid, which are essential for normal growth and development.

Let us highlight other important functions of the substance in the body:

• participates in protein synthesis;
• helps control appetite;
• strengthens the immune system;
• takes part in the production of growth hormone;
• normalizes blood pressure;
• increases the pain threshold;
• effective for hyperactivity syndrome in children;
• helps with chronic fatigue syndrome.

In addition, we can say that taking tryptophan preparations improves the condition of patients with cardiovascular diseases. The substance is also suitable for the complex treatment of alcoholism, as it reduces the toxic effects of ethanol and relaxes the body during withdrawal symptoms. For women, this substance is especially useful because it relieves PMS. Effective in the treatment of obesity as it helps reduce hunger.

Scientific research on tryptophan

5-HTP supplements are widely marketed as a natural remedy for depression.
But science doesn't support 5-HTP for depression. We have decades of clinical trials. And there is no evidence that 5-HTP is effective for depression. The Department of Public Health at the University of Queensland Medical School in Australia conducted a systematic review of the literature between 1966 and 2000 on the subject of 5-HTP and depression.

The researchers found 108 clinical studies, of which only 2 studies, one with serotonin (5-HT) and one with L-tryptophan, included a total of 64 patients. These studies show that serotonin (5-HT) and L-tryptophan are better than placebo in relieving depression.

But the authors Fr.

Is it worth using dietary supplements?

Currently, there is a lot of discussion on the topic of using dietary supplements, including tryptophan. People wonder whether L-tryptophan is beneficial or harmful. One part believes that they cause more harm and do not give the desired effect, like medicines.

Any drug, even the most harmless one, causes harm to the body if it is not used according to the regimen, in increased dosages, and contraindications are not taken into account. In extreme cases, you simply won’t achieve the effect.

• Tryptophan in foods - a list of foods with the highest amino acid content (125 photos)

• Glucosamine chondroitin - instructions for use, tips on how to take the complex and tips on using sports nutrition

• The best fat burners - the best sports drugs and a description of their action. 70 photos and instructions for use

Another sees a panacea in its use, they believe that it can cure 1001 diseases. Benefits in use and positive effects are indeed observed, but you should not count on miracles.

Effect of tryptophan

The amino acid allows us to:

• get quality sleep and feel cheerful;
• relax, relieve irritation;
• neutralize aggression;
• get out of depression;
• do not suffer from migraines and headaches;
• get rid of bad habits, etc.

Tryptophan contributes to maintaining excellent physical shape and a stable emotional background. It helps with lack of appetite and prevents overeating. Maintaining this amino acid in the body at the proper level allows you to go on diets without the risk of stress. (source in English - scientific journal Nutrients, 2016).

Tryptophan treats:

• bulimia and anorexia;
• mental disorders;
• intoxication of various etiologies;
• growth inhibition.

© VectorMine — stock.adobe.com

Food sources

Tryptophan is a traditional component of most protein products.

Amino acid reserves are found in chocolate, oats, dates, milk, yoghurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, sunflower and pumpkin seeds, bananas, peanuts, and corn. You can also replenish the amount of amino acids from asparagus, beet tops, chard, cabbage, broccoli, cauliflower, celery, cucumbers, mushrooms, watercress, herbs, radishes, ginger, pumpkin, carrots, seaweed.

But probably the most popular product, the name of which is traditionally associated with tryptophan, is turkey.
Researchers are divided into 2 groups: some claim that the meat of this bird is extremely rich in tryptophan, others reject this. But recently the debate seems to have come to an end: the parties agreed that turkey meat contains the same amount of tryptophan as most other birds. Top 10 Foods Rich in Tryptophan

Product name (100 g)	Amount of tryptophan (mg)
Seeds, nuts	567
Soy products	575
Cheese	571
Meat	415
Bird	404
Fish	335
Seafood	330
Bran, sprouted grains	335
Eggs	167
Legumes	115

Best materials of the month

• Why you can't go on a diet on your own
• 21 tips on how to avoid buying stale food
• How to keep vegetables and fruits fresh: simple tricks
• How to curb your sweet cravings: 7 unexpected products
• Scientists say youth can be extended

And if we analyze each category of these products, then among seeds and nuts the highest concentration of the substance can be found in sesame, sunflower, pistachios, cashews, almonds and hazelnuts. Among soy products, it is better to give preference to tofu, and parmesan, cheddar and mozzarella are important favorites in the cheese category. Although this does not mean that you should neglect varieties such as edam, gouda or Swiss - they also contain tryptophan.

Rabbit is the meat most saturated with amino acids (100 grams of product contains more than 130% of the recommended daily intake). Somewhat less of the substance, but also quite a lot, is found in pork, goat meat and veal. Among poultry meat, the leaders are chickens, turkeys, chickens (wings and legs).

When choosing fish, it is better to opt for halibut, salmon, trout or mackerel. But you can take anything seafood. Lobster, octopus, shrimp, lobster, crayfish, oysters and scallops, even in small portions, will satisfy the daily need for tryptophan.

The healthiest grains are wheat germ, buckwheat, oatmeal and wheat bran. The best legumes: different varieties of beans and lentils.

If you decide to cook something from chicken eggs, wanting to increase your serotonin levels, know that soft-boiled eggs, scrambled eggs and scrambled eggs contain a little more tryptophan than hard-boiled eggs.

Interesting research

1. Grumpiness

Scientists conducted an interesting experiment with the participation of people who identified themselves as “grumpy.” Participants in the experiment were given 100 mg of tryptophan three times a day, and soon positive results were recorded. People became more compliant, their behavior changed to more pleasant for others, and the test subjects’ desire for quarrel decreased. But 500 mg of the substance, taken once, relieves adolescents from increased physical aggressiveness.

1. Insomnia

Sleep disturbance is the cause of irritability and moodiness in many people. In the 1970s, it was believed that tryptophan taken in a dose of 1-5 grams helped improve sleep quality. But then it was found that 250 mg of the amino acid is enough to enter the deep sleep stage. Further studies have shown that 1 g of the substance helps to effectively combat insomnia, significantly shortens the time to fall asleep, reducing wakefulness in the evening. Tryptophan has also been proven effective in combating obstructive sleep apnea.

1. Malice

It is already known that bad mood, depression and anger are most often the result of a lack of serotonin, and therefore tryptophan. But there is another interesting fact. It turns out that amino acid deficiency can affect facial expressions, causing a more angry expression on the face.

Application of amino acids in industry and medicine

In order for you to have a complete understanding of what kind of substance tryptophan is, you need to talk about the use of amino acids in industry. It is successfully used in pharmaceuticals for the production of food supplements and medicines. The main goals of these drugs are to combat depression and normalize sleep. It has been proven that this unique substance can help even with severe depression and chronic insomnia. In such cases, the dosage of tryptophan preparations is high and reaches 3 g.

In addition, this amino acid is used in the production of animal feed. The additive obtained from it is necessary for agriculture - it helps cattle gain weight and improves food absorption.