Gel for external use Sotex Amelotex - reviews

Indications for use

Meloxicam has anti-inflammatory and anesthetic effects and belongs to the oxicam group. When used topically, it is well absorbed by the skin and penetrates deep into the tissues. When acting on nerve fibers, it reduces pain while increasing joint mobility.

Reduces the activity of COX-2, thereby stopping inflammation at the local level. It has a weaker effect on COX-1. Slowing down the enzymatic synthesis of cyclooxygenases leads to a decrease in pain and a slowdown in the development of the inflammatory process.

The advantage of Amelotex when used externally is the absence of a negative effect on the cartilaginous layers of the joints; the ointment belongs to the group of chondroneutral. It does not stimulate the restoration of cartilage tissue, but does not have a negative effect on them.

Pain relief is observed during movement and at rest, which helps relieve night pain and ensure proper rest.

Lavender and orange oils not only give the ointment a scent, but also have a regenerating effect, relieve vascular spasms, and improve circulation in small vessels. Oils stimulate local immunity and reduce swelling.

Amelotex ointment acts only locally and does not enter the general bloodstream (less than 5%). With insignificant absorption, it is excreted by the kidneys and gastrointestinal tract.

What does Amelotex help with? The official instructions indicate the symptomatic treatment of osteoarthritis, a group of diseases with degenerative changes in the cartilage tissue of the joints. The ointment is effective for the following diseases and conditions:

1. osteochondrosis;
2. arthritis;
3. spondyloarthrosis;
4. arthrosis of peripheral joints;
5. post-traumatic joint diseases;
6. bruises, sprains.

Amelotex helps relieve pain after injuries, reduce inflammation and swelling, and speed up recovery. In dystrophic pathologies, it is of symptomatic significance and does not affect the course of the disease.

Applications and dosages

for adults

The drug is administered intramuscularly. The dose size depends on individual parameters. Usually a 7.5-15 mg solution is prescribed once a day. The minimum dose is used for patients who have an increased risk of side effects. It is prohibited to use more than 15 mg per day. The indicator value is the maximum dose.

When determining the required amount of medication, the doctor will take into account the presence of concomitant diseases. If there is minor or moderate renal impairment or liver cirrhosis in a stable clinical condition, no change in standard dosage is required. If the patient has severe renal failure, the maximum dose is reduced to 7.5 mg per day.

for children

If the patient is under 15 years of age, the medication is not used.

Amelotex injections instructions

The solution is used for intramuscular (parenteral) injections. It is recommended to inject it deep into the muscle, making sure beforehand that the needle does not enter the cavity of the vessel. The instructions for use contain information that the dosage of the drug depends on the specific disease, the severity of its course and the intensity of the symptoms. The initial dose of meloxicam injections prescribed by the doctor is ½ (7.5 mg) ampoule once a day. If necessary, the dosage is increased to 15 mg per day maximum.

The injection is given once at the same time, intramuscularly. The injection must be carried out with the obligatory observance of the rules of antiseptics and asepsis, which will help to avoid infection from entering the human body. It is prohibited to administer a non-steroidal anti-inflammatory drug into the area of ​​subcutaneous hemorrhage or hematoma. According to the instructions, the average duration of therapy is 5 days, sometimes the doctor recommends taking a course of 8-10 days.

Interaction with other drugs

The drug in ampoules is not prescribed simultaneously with other NSAIDs, since this can provoke the development of ulcerative lesions of the gastrointestinal tract and there is a risk of bleeding. In addition, you need to keep in mind that meloxicam has the following effects:

• Provokes an increase in the concentration of lithium in the blood plasma.
• The compatibility of Amalotex with diuretics is an additional risk of kidney problems.
• Use with caution in combination with myelotoxic drugs, cyclosporine and cholestyramine.
• There is a possibility that antihypertensive drugs in interaction with meloxicam will act less effectively.

Amelotex tablets should not be taken simultaneously with acetylsalicylic acid. In addition, all restrictions applicable to ampoules apply.

The drug is a clear liquid with a yellow and green tint. It is packaged in transparent ampoules. Their volume is 1.5 ml. The ampoules are placed in blister packs. Each of them contains 3 or 5 ampoules. The medicine is sold in a cardboard box. Each of them can contain from 3 to 20 ampoules.

If the medication is used in conjunction with intrauterine contraceptives, their effectiveness may be reduced.

Doctors do not exclude the possibility of interaction of the drug with biochemical agents intended for oral use, but the exact result of the combined use of medications is unknown.

If it is necessary to use Amelotex together with Cholestyramine, this will lead to increased excretion of the first drug through the gastrointestinal tract.

If Amelotex is taken together with other medications included in the NSAID group, the likelihood of erosive and ulcerative lesions and bleeding from the gastrointestinal tract increases.

If lithium preparations are used simultaneously with the medication, accumulation of the latter substance may occur. Experts advise that it is mandatory to monitor the amount of lithium in the blood plasma if combination therapy cannot be avoided. The combined use of Amelotex with other medications is possible only as prescribed by a specialist.

If you are already undergoing treatment with any medications, you should consult your doctor about their compatibility before starting to use Amelotex. It should be taken into account that often the simultaneous use of certain medications can have negative consequences.

The simultaneous use of Amelotex and other drugs from the group of non-steroidal anti-inflammatory drugs significantly increases the risk of developing stomach ulcers, duodenal ulcers, and gastrointestinal bleeding.

Combined use with methotrexate enhances the myelosuppressive effect, and with intrauterine contraceptives and antihypertensive drugs reduces their effectiveness.

When combined with drugs from the group of anticoagulants (Heparin), antithrombic agents (Ticlopidine), fibrinolytics, the likelihood of bleeding of any kind increases significantly.

Patients taking diuretics and Amelotex simultaneously should take sufficient fluids. You should be aware that diuretics increase the risk of developing kidney dysfunction. Combination with Cyclosporine can also negatively affect the functioning of the kidneys.

Combination with Kolestyramine accelerates the elimination of meloxicam from the body.

The drug is quite effective, so reviews of its use are mostly positive. There are also negative opinions from patients who did not follow the recommendations or are allergic to the components of the medicine.

I suffer from a chronic form of radiculitis and quite often use various ointments to relieve pain. At my last appointment, the doctor prescribed me Amelotex gel. Its price is reasonable and I decided to try it. For 10 days I applied it twice a day, rubbed in a little and waited for absorption. I did not experience any discomfort during the procedure. I didn’t notice the effect immediately, but only after 3 days. At the end of the course, I began to move much easier, the pain in the lumbar region had almost disappeared. Now I can cover a long distance and get much less tired. I am completely satisfied with the effect of the drug.

Oleg

Amelotex ointment was prescribed to me for a bruised shin. I play sports professionally, so I often get various injuries. I usually don’t use any products because everything goes away on its own. But after a shin injury, the pain did not disappear for a long time and I consulted a doctor. He noted that the damage was mild and said that the gel would be sufficient. I applied it according to the instructions and after 4 days all the symptoms disappeared. Now I always have this medicine in my medicine cabinet.

Konstantin

I take Amelotex injections every 6 months because I have suffered from arthritis for a long time. Previously, she was treated only with pills, but recently her condition has worsened sharply and a specialist suggested taking a course of therapy in a hospital. I was prescribed a drip and intramuscular injections. After the first procedure I felt an improvement. The pain has decreased significantly. After 5 days, everything returned to normal, the morning stiffness when moving went away, and walking became much easier. I am very pleased with the effect of the drug.

Antonina

Amelotex is an effective and affordable non-steroidal drug. Allows you to quickly normalize the patient’s condition with various degenerative-dystrophic and inflammatory pathologies. When used correctly and in compliance with the dosage, it does not provoke adverse reactions. Before starting the course, it is recommended to consult with a specialist.

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Amelotex release form and composition

Amelotex is available in the form of tablets for oral administration, a solution for intramuscular injections, a gel (cream) for external use, and a suppository (suppositories) for rectal use.

1. Amelotex tablets are round, biconvex, pale yellow in color. A slight greenish tint, marbling and slight roughness are allowed. As an active substance, one tablet contains 7.5 or 15 mg of meloxicam. Tablets are packaged in 10 pcs. in blister packs (blisters). They go on sale in cardboard packs containing 1 or 2 blisters of the drug and instructions for use.
2. For intramuscular administration, Amelotex is available in ampoules with a solution in the form of a transparent or slightly opalescent (shine, shine) liquid of yellow color with a greenish tint. The ampoule contains 1.5 ml of a solution ready for injection, which, along with auxiliary components, contains 15 mg of the active substance - meloxicam. In pharmacies, Amelotex for injections can be purchased in packages of 3 and 5 ampoules.
3. Amelotex for external use is available in the form of a transparent or translucent yellowish gel (1%), which has an unusual but rather pleasant odor.
   The drug is packaged in tubes of 30 and 50 grams. The gel contains the main active ingredient - meloxicam 1 g, as well as auxiliary components: carbomer, trometamol, methylpyrrolidone, ethanol, orange flower and lavender oils, purified water.
4. Rectal suppositories are greenish-yellow in color and torpedo-shaped. One suppository may contain 7.5 mg or 15 mg of meloxicam and auxiliary components. The package contains 1 blister with 6 suppositories and instructions for using the drug.

Amelotex tablets, ampoules and suppositories are available in pharmacies with a doctor's prescription.

You don't need a prescription to buy the gel. However, the use of the gel is not recommended without consulting a doctor. The doctor will prescribe the exact dosage, write out the treatment regimen, and control the required duration of use.

Uncontrolled use leads to side effects, blurs the picture of the disease, which interferes with correct diagnosis and is harmful to health.

Composition, pharmacological forms of the drug

"Amelotex" gel is produced by the manufacturer in the form of a gel, which is intended for external use. Externally, the product looks like a transparent mass with a homogeneous consistency, cream, yellow or yellow-green tint. The drug has an unstable pleasant aroma. The ointment is packaged in aluminum tubes, each of which can contain 30 and 50 grams of the product. Additionally, the tubes are packaged in cardboard packs, complete with annotations.

The main active ingredient of the drug is meloxicam. Its effect can be enhanced by such auxiliary components as:

1. Distilled water.
2. Carbomer. It is a medicinal substance base that ensures the penetration of the drug components into the affected tissues.
3. Methylpyrrolidone. It is a synthesized solvent with a natural base.
4. Orange flower and lavender extract. They are catalysts for meloxicam, promoting muscle relaxation and calming.

In addition to the gel, there are such pharmacological forms of Amelotex on sale as ampoules, tablets, and rectal suppositories. However, it is the gel that has gained the greatest popularity among patients.

What patients are talking about

As patients who have taken the drug in question note in their reviews of Amelotex, injections of this medication are both a positive experience, since the substance helps well, and a negative one, since side effects occur. In general, responses to the drug are rather positive, since the drug copes with the tasks for which it was developed. The features of Amelotex are very well known to people who are concerned about osteochondrosis, back and lumbar, joint and rheumatic pain. Such a syndrome can seriously spoil a person’s life, worsen not only the physical but also the mental state, and complicate social life.

Many people who have used Amelotex compare this medication with other non-hormonal anti-inflammatory drugs. The main conclusion is this: meloxicam works more effectively, provides better pain relief, and is therefore preferable to ibuprofen and drugs based on it. As patients who have used Amelotex admit, this remedy relieves pain and acts quickly, although it causes side effects, but they are relatively weak.

Question answer

Question: Hello, I would like to clarify whether it is possible to take alcohol if I am being treated with this medication? Doctor's answer: Drinking alcohol while being treated with any NSAIDs is prohibited, as there is a high risk of bleeding from the gastrointestinal tract.

Question: Hello. Which is better: Diclofenac or Amelotex? Doctor's answer : Since Diclofenac inhibits COX indiscriminately, it can lead to gastric or duodenal ulcers. Therefore, Amelotex is better.

Question: Hello. Is it possible to take several NSAIDs at the same time? Doctor's answer: When taking several NSAIDs at the same time, the risk of bleeding increases.

Question: Does this drug affect the effectiveness of intrauterine contraceptives? Doctor's answer: This drug reduces the effectiveness of intrauterine contraceptives.

Question: Hello. Can I take this medicine with medications to lower blood pressure? Doctor's answer: The drug reduces the effectiveness of antihypertensive drugs.

Description of the drug

The drug in question is a soft dosage form with a pronounced anti-inflammatory effect. Used to treat joints and pathologies of the musculoskeletal system. The active ingredient of the drug is meloxicam, which is characterized by analgesic, antipyretic and anti-inflammatory effects.

Clinical and pharmacological group

Amelotex gel is a representative of the clinical and pharmacological group of non-steroidal anti-inflammatory and anti-rheumatic drugs. The active ingredient of the drug is meloxicam. It quickly penetrates into the pathogenic area, mainly into the synovial fluid, where it accumulates, providing a therapeutic effect.

pharmachologic effect

Amelotex is recommended for use for joint diseases accompanied by inflammation and pain. The gel helps to cope with unpleasant sensations in the problem area, eliminate fever, and relieve inflammation.

The mechanism of pharmacological action of meloxicam:

• The active substance specifically inhibits COX3, which eliminates the production of prostaglandins.
• With prolonged use of the drug, the selectivity of action is leveled out.
• The synthesis of prostaglandins decreases in the inflamed area.
• Prolonged use of the drug invariably leads to inhibition of cyclooxygenase-1.

Natural essential oils soothe and relax inflamed tissues. The drug has a local effect; during course therapy it provides high motor activity.

Release form and composition

The medication in question is available in the form of a gel for external use. We are talking about a transparent homogeneous consistency with a cream, yellow or yellow-green tint. The medicine has a pleasant, non-persistent odor. The gel is packaged in metal tubes of 50 and 30 g. The medication is supplied in a cardboard box with an annotation and instructions for use.

The main active element of the composition is meloxicam, the properties of which have already been mentioned above. A number of auxiliary ingredients enhance its effect:

1. Lavender and orange flower extracts are catalysts for the main component of the gel, helping to soothe and relax muscles.
2. Methyrrolidone is a synthesized solvent on a natural basis.
3. Carbomer is a medicinal base of a substance that ensures the penetration of the ingredients of the composition into problem tissues.
4. Distilled water.

Medicines are available on sale in the form of rectal suppositories, tablets and ampoules. But among ordinary patients, it was the gel that found particular popularity.

Storage conditions and periods

According to the instructions specified in the annotation for the drug, it is recommended to store it in a dark place, away from sources of moisture and ultraviolet radiation. The optimal temperature range is from 15 to 25 °C. It is strictly forbidden to freeze the medicine, since the effectiveness of the drug is neutralized.

Instructions for use

According to the instructions for use, Amelotex gel is applied only to clean and dry skin. The product is used exclusively externally, locally. The area to be treated is an area of ​​the dermis that does not have any open or unhealed wounds or scratches. Otherwise, you will have to stop using the medication.

1. A small amount of gel (a strip 2.5-3 cm long) is evenly distributed over the problem area.
2. The thick consistency is gently rubbed into the epithelial layer with light massaging movements for 3-4 minutes.
3. The frequency of treatment of the back and joints is 2-3 times a day, as recommended by a doctor.
4. The optimal period for applying the gel is in the evening and in the morning. The duration of therapy varies from 1 to 4 weeks, depending on the nature of the pathological process.

In the absence of a positive therapeutic effect, it is strictly forbidden to independently increase the daily dosage of the drug. This is possible only after consultation with a specialist.

Indications and contraindications

The medicine in question is used to eliminate pain and inflammation that occurs due to pathologies of the musculoskeletal system.

Indications for use of Amelotex ointment:

• arthrosis;
• joint diseases of rheumatic etiology;
• osteoarthritis of the deforming type;
• sprains and bruises;
• osteochondrosis;
• Bekhterev's disease.

Despite the fact that the components of the gel help relieve painful symptoms and stop inflammation, they do not affect the nature of the pathological process.

Meloxicam-based medications should not be used for:

• dermatitis;
• bronchial asthma;
• polyps in the nasopharynx;
• individual intolerance to the components of the drug;
• minor teenagers;
• violation of the integrity of the skin;
• breastfeeding a child;
• pregnancy.

It is important to consult a doctor before treatment. Particular care should be taken by patients with stomach diseases, liver pathologies, and heart failure.

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An effective analogue of Amelotex ointment Mataren Plus is a drug for the treatment of joint diseases and injuries.

Directions for use and doses

Taking Amelotex ointment inside the body is strictly prohibited. Other dosage forms of the drug have been developed for this purpose. Since we are talking about an external product, it is applied only to the surface of the problem area of ​​the skin. A strip of medication 3 cm long is evenly distributed over the painful area, then rubbed into the epithelial layer with massaging movements for 3-4 minutes.

The limit daily dosage is 14 g. It is not recommended to use this product in combination with other external or internal drugs.

Side effects and special instructions

Ameolotex cream is characterized by high tolerability among patients. A small amount of the active substance enters the main bloodstream. Adverse reactions are recorded mainly in patients with individual intolerance to meloxicam.

Possible side effects:

• epithelial peeling;
• local burning and itching;
• redness in the area where the gel is applied;
• allergic reactions - rash, erythrema, irritation;
• hypersensitivity of the dermis to ultraviolet radiation.

If these reactions occur, it is important to stop treatment with the gel and seek medical help.

Sometimes you can't

The use of Amelotex (in injections, tablets) is prohibited if the patient is hypersensitive or intolerant to meloxicam or any other substance used by the manufacturer in the manufacture of the drug. The use of the described drug is strictly prohibited for persons who have recently undergone coronary artery bypass surgery, as well as for patients who have been diagnosed with decompensated heart failure. Contraindications for the use of Amelotex are erosive processes, ulcerative lesions in the gastrointestinal mucosa, as well as bleeding in this area.

Amelotex, produced in ampoules, should not be used for inflammatory pathologies of the intestinal tract. Contraindications include Crohn's disease and nonspecific colitis. The medication is not prescribed if the patient has a combination of asthma, nasal polyposis, prone to relapse, and intolerance to acetylsalicylic acid, as well as other non-hormonal anti-inflammatory drugs. "Amelotex" is prohibited both with a complete combination of these three factors, and with a partial coincidence. Not only the patient’s current condition is taken into account, but also the medical history.

Suppositories relieve pain

Suppositories are a dosage form. Indications for their use are the following pathological processes:

• Bekhterev's disease;
• pain syndrome due to degenerative processes in the joints.

When the patient's condition has stabilized, Movalis suppositories are inserted into the rectum. In this case, a high concentration of the drug is created.

Rectal administration of suppositories avoids irritation of the gastric mucosa. Suppositories are used if it is difficult for a patient to take medicine by mouth in the presence of a head injury, nausea and vomiting.

The introduction of a suppository has a systemic effect on the body.

In the treatment of the patient, a three-stage scheme for the use of Meloxicam is used, always prescribing suppositories if well tolerated. The maximum concentration of the active substance in the blood occurs 5–6 hours after administration of the drug.

Remelox suppositories are prescribed rectally as part of combination therapy. The drug is not used in children and pregnant women.

Contraindications for use

Despite the effectiveness of the medicine, its use can be harmful to health. There are several contraindications that will become an obstacle to therapy:

• hypersensitivity to the components of the product or a tendency to allergic manifestations;
• period of pregnancy and breastfeeding;
• children and adolescents up to 18 years of age;
• peptic ulcer in the acute stage with the threat of perforation of the wall of the stomach or duodenum;
• acute colitis and enteritis;
• liver failure or cirrhosis of the liver;
• acute hepatitis;
• chronic renal failure;
• infectious pathologies in the acute period;
• bronchial asthma with frequent attacks of breathlessness;
• aspirin asthma;
• pancreatitis in the acute stage;
• acute myocardial infarction or ischemic stroke;
• tendency to bleeding, impaired production of clotting factors;
• hemolytic anemia;
• individual sensitivity to lactose;
• atherosclerotic changes in blood vessels;
• recovery period after surgical interventions on the coronary vessels or internal organs.

Suppositories are contraindicated for hemorrhoids, anal fissures, inflammation of hemorrhoids, since they have a rather aggressive effect and can cause complications.

The medicine is used with extreme caution for the treatment of elderly patients with heart failure, coronary heart disease, and severe persistent arterial hypertension. You should not combine the medicine with others from the group of non-steroidal anti-inflammatory drugs, since the risk of complications increases significantly

Simultaneous use with anticoagulants increases the chance of bleeding several times. It is worth noting that the medicine somewhat weakens the effect of antihypertensive and diuretic drugs

You should not combine the medicine with others from the group of non-steroidal anti-inflammatory drugs, since the risk of complications increases significantly. Simultaneous use with anticoagulants increases the chance of bleeding several times. It is worth noting that the medicine somewhat weakens the effect of antihypertensive and diuretic drugs.

Contraindications

Amelotex is prohibited from being used in the following situations:

• excessive sensitivity to the active ingredient or excipients;
• performing coronary artery bypass grafting in the recent past;
• heart failure at the stage of decompensation;
• a combination of worsening nasal and sinus polyposis, asthma and intolerance to aspirin and other non-steroidal anti-inflammatory drugs;
• active stage of bleeding in the digestive organs;
• age less than 15 years;
• ulcerative lesions of the stomach and duodenum;
• complex forms of liver failure or active pathology of the organ;
• intestinal inflammation;
• cerebrovascular bleeding or other forms of abnormality;
• lactation;
• complex forms of liver failure that are not subject to dialysis;
• progressive kidney pathologies, including confirmed hyperkalemia;
• pregnancy;
• inflammation of the rectum or anus, bleeding from this area - rectal suppositories are contraindicated.

It is worth considering that the tablets contain lactose. Therefore, the medicine is contraindicated for people with rare genetic pathologies - substance intolerance, lactase deficiency. Also, the product is not recommended for people with glucose-galactose malabsorption.

Description of the drug

Amelotex gel, the instructions for use of which are quite simple, is a product with a sticky texture, but at the same time it is somewhat light. It has a pleasant aroma, which many call unusual. This smell disappears quickly and is not irritating. The gel can be packaged in tubes with a dosage of 30 and 50 g.

The composition of such a medicine is as follows: 100 g of the product contains the active substance meloxicam - 1 g. Among the auxiliary ingredients are methylpyrrolidone, ethanol, carbomer, trometamol, orange flower oil, lavender oil, water.

The active substance of the drug, meloxicam, has a pronounced analgesic effect. It also perfectly relieves inflammation and soothes damaged tissue.

This drug is easily absorbed and begins to work immediately after application. Amelotex gel is an over-the-counter drug

However, it is important to understand that you cannot prescribe such a remedy yourself. After all, there is a high risk of not guessing with contraindications, getting many side effects, etc.

The components of the gel quickly penetrate into the deeper layers of the skin. It should be applied carefully, but with massaging movements. Then all that remains is to wait for it to be absorbed. Meloxicam restores and relieves pain, essential oils relax, soothe and enhance the healing components of the medicinal substance.

It must be remembered that the product only works in the application area. Moreover, its use produces an effect both at rest and in motion.

Meloxicam, which is the basis of the gel, has no effect on cartilage. Essential oils provide a relaxing effect and allow tissues to regenerate faster. In addition, they disinfect.

Indications for use of the product

Most often, Amelotex gel is prescribed for various degenerative diseases. It is also prescribed for various injuries of the articular apparatus. The gel is used for the following pathologies:

• Deforming osteoarthritis;
• Rheumatoid arthritis;
• Ankylosing spondylitis;
• Osteochondrosis and spondyloarthrosis;
• Post-traumatic inflammation.

Contraindications and side effects

A prerequisite when selecting a drug is to take into account contraindications. After all, it cannot be used by everyone and not in all conditions. And this point must be studied so as not to harm your health. Thus, among the prohibitions on the use of such a medicinal substance are:

1. Hypersensitivity and individual intolerance to the components of the drug;
2. Sensitivity to other non-steroidal anti-inflammatory drugs;
3. Complete or incomplete combination of asthma, nasal polyposis (especially recurrent), intolerance to acetylsalicylic acid;
4. Violation of the integrity of the skin in the areas where the gel will be applied;
5. Children's age – inclusive up to 18 years;
6. Pregnancy.

People with gastric and duodenal ulcers should use it very carefully, especially if they are in the acute phase. You should also carefully use the product for those who have:

You should also carefully use the product for those who have:

• Gastrointestinal bleeding in the active phase;
• Kidney problems;
• Liver failure;
• Hyperkalemia;
• Intestinal inflammation;
• Elderly age;
• Problems with coagulation;
• Chronic heart failure.

It is also important to understand that the use of any drug can cause some side effects. They usually appear during clinical trials

This does not mean at all that they will definitely appear, but there are risks and they must be taken into account

They usually appear during clinical trials. This does not mean at all that they will definitely appear, but there are risks and they must be taken into account.

Topical drugs from the series of non-steroidal anti-inflammatory drugs are characterized by side effects such as:

1. Skin hyperemia;
2. Rashes in the form of papules;
3. Peeling of the skin;
4. Photosensitivity;
5. Itching and burning of the skin;
6. Hives;
7. Anaphylactic manifestations.

If side effects become fully apparent, you should immediately consult a doctor and stop using Amelotex gel. It is imperative to wash off the gel from the skin.

Healing gels and creams

Amelotex gel has a pronounced analgesic effect, and regular use helps to cope with many problems and restores ease of movement. Medicines containing meloxicam have less pronounced side effects and do not cause an allergic reaction.

The gel is used to treat school-age children and patients with stomach and intestinal diseases. This group of medicinal substances includes drugs:

• Oxycamox;
• Exen-Sanovel;
• Mataren Plus cream.

Medicines from the oxicam group, including Exene-Sanovel gel, are not prescribed for stomach diseases, infectious processes, or patients with nephrotic syndrome. During pregnancy and breastfeeding, medications containing meloxicam are contraindicated.

Gel Mataren Plus has an anti-inflammatory effect and eliminates pain. Exceeding the dosage may cause a deterioration in the condition of the patient suffering from kidney or bladder disease. Meloxicam, which is part of the drug, causes itching and flaking of the skin.

Is there an alternative

The remedy described above is considered quite effective and efficient, but the patient does not always have the opportunity to purchase it. If you need to choose an analogue of Amelotex, injections or tablets are agreed with the doctor - the alternative remedy should be as effective and safe as possible. It is very difficult to independently determine for yourself which potential analogue is suitable in a particular case.

The following effective anti-inflammatory drugs are available:

• "Movalis".
• "Melbek".
• "Exan."

Sometimes the doctor advises you to choose the drug "Mirlox". The fairly affordable medicine Meloxicam-Stada has a good reputation.

Before purchasing, it will not be superfluous to read the opinions of patients and reviews of analogues of Amelotex. Many people have had to endure injections of non-hormonal anti-inflammatory drugs, so they have accumulated considerable experience. However, as can be seen from open sources, mainly people who took the drugs listed above noted their effectiveness. Almost everyone noticed some side effects. It is difficult to conclude from the responses alone whether the drug in question or one of its potential substitutes is better. The choice in a particular case is best left to a doctor who can take into account the specifics of the diagnosis and the condition of the patient’s body.

Pharmacokinetics of the drug

When ingested, the active component of the pharmacological agent is quickly absorbed in the digestive tract, namely in the small intestine. Bioavailability is almost 90%, which explains its speed and effectiveness. The maximum concentration in the blood is observed 2 hours after administration.

It is noted that the drug accumulates in large quantities in tissues, especially in synovial fluid, and provides a prolonged effect. When using the injection form and rectal suppositories, the absorption period is reduced and bioavailability approaches 100%. Treatment with an external agent is also effective, but the absorption of components into the blood is minimal.

Metabolism of the active components occurs in the liver, where they break down into active metabolic products. The elimination period is quite long and can last more than a day. This is due to the cumulative effect. The main amount of metabolites is excreted in the urine and a small amount is excreted in feces. In patients with severe kidney pathologies, the time it takes for the body to free itself from breakdown products increases by several hours, depending on the severity of the condition.

Indications and contraindications

The use of Amelotex injections is indicated for diseases of the structures of the musculoskeletal system, if the pathology is associated with inflammation. The medicine is used against inflammatory and degenerative diseases of the joints, due to which a person feels pain.

What else does Amelotex help with:

• Rheumatoid arthritis. The inflammatory process inside the joints develops due to problems in the functioning of the immune system, against the background of which autoantibodies have begun to be produced, negatively affecting the tissues of the joints.
• Anklyosing spondylitis. This disease is also autoimmune in nature, but it completely affects the spine, leading to severe pain and problems with mobility.
• Osteoarthritis. This joint disease is of a degenerative-dystrophic nature, due to which cartilage tissue is destroyed.
• Arthritis. In this case, inflammation occurs due to local hypothermia, bacterial activity or some other factors.

Amelotex injections are used primarily in complex therapy of various inflammatory diseases of the musculoskeletal system.
The medicine has numerous contraindications. First of all, it is prohibited if an allergy to the components of the composition is possible, or if reactions to other non-steroidal anti-inflammatory drugs have previously occurred. Amelotex is not used for heart failure, especially in the stage of decompensation. Also contraindications include:

• Recovery period after coronary artery bypass surgery,
• Cerebrovascular bleeding;
• Complete or incomplete recurrent polyposis, which is combined with intolerance to non-steroidal anti-inflammatory drugs,
• Erosion or ulcer in the stomach or duodenum,
• Bleeding in the gastrointestinal tract,
• Severe renal or liver failure,
• Inflammatory bowel pathologies such as ulcerative colitis.

Amelotex is not given to children under 15 years of age. It is contraindicated for pregnant women and nursing mothers. A number of diseases require additional medical consultation before injections. These include coronary heart disease, diabetes mellitus, peripheral arterial disease, previous ulcers in the gastrointestinal tract and long-term use of other NSAIDs.

Limitations and nuances

Amelotex is prohibited for bleeding, including cerebrovascular bleeding. The drug is not used against the background of severe liver diseases or severe insufficiency of this organ.

You cannot prescribe Amelotex injections to a patient if this person is under 15 years of age. The drug is not used to treat pregnant women or mothers feeding their babies with their own milk.

In case of kidney failure, Amelotex is not prescribed if the patient is not undergoing dialysis and the creatinine clearance is less than 30 ml/min. Do not use the drug if you have a kidney disease that is actively progressing at the moment. The medication should not be used if studies have confirmed excessive accumulation of potassium in the body.

special instructions

Before starting intramuscular treatment with the solution, you should familiarize yourself with the features of using the medicine:

Administration of the drug to pregnant and lactating women and children under 15 years of age is prohibited. The dosage is adjusted, and injections are prescribed very carefully for liver diseases, impaired renal function, ulcerative lesions of the gastrointestinal tract (gastrointestinal tract), erosive changes in the mucous membrane of the stomach and duodenum. Such patients should be under medical supervision throughout the course of therapy. The dose of medication for elderly patients is reduced. If we talk about the interaction of Amelotex injection solution, then according to the instructions, its use with other medications should be as careful as possible

Intramuscular injections reduce the effectiveness of intrauterine contraceptives and antihypertensive drugs, and increase the level of lithium concentration in the blood plasma. Thrombolytics, heparin, therapy with anticoagulants, lithium drugs increase the risk of bleeding; taking diuretics can lead to kidney disease; cholestyramine accelerates the elimination of meloxicam. Considering the fact that drowsiness may occur after using the medicine, it is not recommended to inject it into people whose activities require constant increased concentration and an immediate psychomotor reaction. Alcohol intake does not affect the effect of Amelotex injections.

Contraindications

Before use, you should carefully read the list of contraindications specified in the instructions for the drug. The drug Amelotex in any form is not used if the patient:

• previously noted intolerance to NSAID drugs or an allergic reaction to components;
• cerebrovascular accident;
• uncompensated heart failure;
• bronchial asthma with complete and incomplete combination with polyposis (presence of benign diseases) of the nose and paranasal sinuses and intolerance to aspirin (acetylsalicylic acid).
• erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding;
• Crohn's disease;
• ulcerative colitis (aggravated);
• period after coronary artery bypass surgery;
• severe liver failure or active liver disease;
• progressive kidney disease;
• inflammation of the rectum and violation of its integrity (for suppositories).

Contraindications to the use of Amelotex gel are traumatic injuries to the skin at the site of application, and the presence of dermatological diseases.

Amelotex in all forms is not used to treat pregnant and lactating women.

A number of diseases and conditions for which the use of Amelotex is possible, but with extreme caution and with mandatory medical supervision:

• history of upper gastrointestinal diseases;
• simultaneous anticoagulant therapy;
• diabetes;
• cardiac ischemia;
• inflammatory processes in the intestines;
• kidney disease (careful monitoring of diuresis and kidney function is necessary);
• active liver disease;
• peripheral arterial disease;
• gastrointestinal bleeding;
• hyperkalemia;
• elderly age;
• frequent drinking of alcohol.

If there is no expected effect, you should not independently increase the recommended dose or extend the course of treatment determined by the doctor. The right decision in any doubtful case would be to consult a doctor for advice.

special instructions

Amelotex has a number of significant drug interactions.

When taken simultaneously with other NSAIDs (also with acetylsalicylic acid), the risk of erosive and ulcerative lesions and gastrointestinal bleeding increases.

When used simultaneously with antihypertensive drugs, their effectiveness may decrease.

When taken simultaneously with lithium preparations, the development of accumulation of lithium and an increase in its toxic effect is possible (monitoring of lithium concentrations in the blood is required).

When used simultaneously with methotrexate, its side effects on the hematopoietic system are enhanced (anemia and leukopenia are possible; periodic blood monitoring is recommended).

When taken simultaneously with cyclosporine and diuretics, the risk of developing renal failure increases.

When used simultaneously with intrauterine contraceptives, their effectiveness may be reduced.

With simultaneous therapy with anticoagulants (warfarin, heparin, ticlopidine), with thrombolytic agents (streptokinase, fibrinolysin), the risk of bleeding increases (periodic monitoring of blood clotting parameters is required).

When used together, Amelotex and cholestyramine, as a result of the binding of meloxicam, its excretion through the gastrointestinal tract is enhanced.

When taking Amelotex and selective serotonin reuptake inhibitors simultaneously, the risk of gastrointestinal bleeding is higher.

special instructions

In certain categories of patients at risk of adverse side effects, when using Amelotex, it is necessary to exercise caution and monitor renal function indicators

With a persistent and noticeable increase in transaminases, as well as with changes in other indicators of liver function, discontinuation of the drug and control tests are required.

Patients taking diuretics concomitantly with meloxicam should drink sufficient fluids.

Meloxicam is able to mask the symptoms of infectious diseases.

Amelotex should not be used by women planning pregnancy due to its possible negative effect on fertility.

The use of Amelotex may cause drowsiness, headache or dizziness. In this regard, during the period of therapy it is recommended to postpone activities that require special concentration and attention, and also to refuse to drive any vehicle.

Side effects

When using the drug Amelotex, the body may react negatively, which will manifest itself in adverse reactions.

Indications and contraindications for use

The accumulation of the active component in joint tissues allows Amelotex to be widely used for diseases of the musculoskeletal system. Doctors prescribe injections for the following pathologies:

• rheumatoid arthritis (an inflammatory process in the joints that occurs due to the production of antibodies that attack healthy tissue);
• osteoarthritis (a degenerative-destructive process accompanied by thinning of cartilage tissue);
• ankylosing spondylitis (an autoimmune pathology that affects all components of the spine, accompanied by fusion of the vertebrae and severe pain);
• arthritis (infectious or aseptic inflammation of the joints).

The drug is contraindicated in the following pathological and physiological conditions:

• allergic reactions to the components of the solution and non-hormonal anti-inflammatory drugs;
• recovery after interventions in the coronary vessels;
• cardiogenic shock;
• bronchial asthma, combined with sinus polyposis and allergy to acetylsalicylic acid;
• erosive or ulcerative lesions of the mucous membranes of the digestive system;
• active or recent intestinal bleeding;
• inflammatory processes in the large intestine (ulcerative colitis);
• hemorrhages in the brain;
• blood clotting disorder;
• severe liver failure, acute inflammatory processes in the liver;
• actively developing kidney diseases, including hyperkalemia;
• severe renal dysfunction in patients not undergoing dialysis;
• rare genetic pathologies (lactase deficiency, glucose-galactose malabsorption); childhood (up to 16 years).

The anesthetic is used with caution for the following pathologies:

• ischemic lesions of the heart muscle;
• cerebrovascular accident;
• circulatory disorders;
• diabetes;
• peripheral arterial lesions;
• previous stomach and intestinal ulcers;
• Helicobacter pylori infection;
• elderly and senile age;
• long-term use of non-steroidal anti-inflammatory drugs;
• severe chronic pathologies;
• simultaneous administration of anticoagulants and antiplatelet agents, glucocorticosteroids and serotonin reuptake inhibitors.

Contraindications

A contraindication is the patient's hypersensitivity to the drug.

It is not used in the period after coronary artery bypass surgery or in case of decompensated heart failure.

Contraindicated in complete or incomplete combination of bronchial asthma with recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (also in history).

The drug is not used in the presence of erosive and ulcerative changes in the gastrointestinal mucosa, active gastrointestinal bleeding, as well as in the case of inflammatory bowel diseases (such as ulcerative colitis or Crohn's disease).

Cerebrovascular bleeding, like other bleeding, is also a contraindication. Amelotex is not indicated in cases of severe liver failure, with active liver disease, as well as in the presence of severe renal failure in patients not undergoing dialysis (with creatinine clearance less than 30 ml/min) and with progressive kidney diseases, incl. in case of confirmed hyperkalemia.

Amelotex is contraindicated for pregnant and breastfeeding women and children under 15 years of age. Patients with rare hereditary diseases (lactose intolerance, lactase deficiency, with concomitant glucose-galactose malabsorption) are not recommended to prescribe the drug due to the presence of lactose in the drug.

As a precaution, to reduce the risk of unwanted effects, it is recommended to use the minimum effective dose for the shortest possible course in the following cases:

• with existing ischemic heart disease;
• congestive heart failure;
• cerebrovascular diseases;
• dyslipidemia or hyperlipidemia;
• in case of diabetes;
• peripheral arterial diseases;
• when smoking;
• creatinine clearance less than 60 ml/min;
• if there is a history of ulcerative lesions of the gastrointestinal tract;
• Helicobacter pylori infections;
• elderly patients;
• in case of long-term use of NSAIDs;
• severe somatic diseases;
• with frequent alcohol consumption;
• concomitant therapy with anticoagulants (warfarin);
• antiplatelet agents (such as acetylsalicylic acid or clopidogrel);
• oral corticosteroids (such as prednisolone);
• selective serotonin reuptake inhibitors (sertraline, citalopram, paroxetine, fluoxetine).

Amelotex gel composition

100 g of gel contains: active substance: meloxicam (in terms of 100% substance) - 1.0 g;

excipients: methyl lyrrolidone - 15.0 g, ethanol 95% - 25.0 g, carbomer - 0.9 g, trometamol - 2.0 g to 3.0 g (up to pH 7.5-8.9), orange flower oil - 0.015 g, lavender oil - 0.01 g, purified water - up to 100.0 g.

Description Transparent or almost transparent gel of yellow or yellow with a greenish tint with a specific odor.

Pharmacotherapeutic group: non-steroidal anti-inflammatory drug for external use.

ATX code: M02AA

Pharmacological properties Pharmacodynamics Amelotex gel contains meloxicam, a non-steroidal anti-inflammatory drug (NSAID), which has an analgesic and anti-inflammatory effect. The anti-inflammatory effect is associated with inhibition of the enzymatic activity of cyclooxygenase-2 (COX-2), which is involved in the biosynthesis of prostaglandins in the area of ​​inflammation.

To a lesser extent, meloxicam acts on cyclooxygenase-1 (COX-1), which is involved in the synthesis of prostaglandin, which protects the mucous membrane of the gastrointestinal tract and takes part in the regulation of blood flow in the kidneys. Meloxicam is a “chondroneutral” drug, does not have a negative effect on cartilage tissue, and does not affect the synthesis of proteoglycan by chondrocytes of articular cartilage.

When applied topically, the drug reduces or eliminates pain in the area where the gel is applied, including joint pain at rest and during movement. Helps increase range of motion.

Pharmacokinetics Studies on rabbits have established that meloxicam, when applied cutaneously in the form of a gel, is characterized by prolonged transdermal absorption, prolonged circulation in the blood and gradual elimination, significantly different in kinetic characteristics from the intramuscular route of drug administration. There is no data indicating significant absorption of meloxicam into the systemic circulation.

In the systemic circulation, meloxicam binds tightly to plasma proteins, mainly albumin (99%). It undergoes biotransformation in the liver with the formation of inactive metabolites. It is excreted mainly in the form of metabolites in urine and feces in approximately equal proportions.

Kinetics

After injection of Amelotex, the active component is absorbed into the circulatory system, where it reacts with plasma proteins. The degree of binding is estimated at 99%. It has been established that meloxicam is able to penetrate the histohematic barriers of the body. Studies have revealed its presence in intra-articular fluid. On average, its concentration is half that observed in blood serum.

As indicated in the annotation accompanying Amelotex ampoules, the active component of this drug is eliminated by the kidneys and intestinal tract in approximately equal proportions. Most elimination occurs in the form of meloxicam processing products. About 5% of the dose received per day is excreted from the body in its original form with the contents of the intestines. It was possible to detect an untransformed substance in trace concentrations in urine.

Mechanism of action

Amelotex injections affect the COX-2 enzyme, which triggers the production of prostaglandins - chemicals released by tissues during the inflammatory process. They irritate the nerve endings, causing pain in the affected area. An increase in the permeability of vascular walls promotes the release of blood plasma into the intercellular space, which causes swelling. Prostaglandins prevent the flow of blood from inflamed joints, resulting in a reddish tint to the skin.

There are several types of prostaglandins produced in the human body. Some of them do not contribute to the development of the inflammatory process. They are located in the stomach and protect the mucous membranes of the organ from ulceration. The enzyme COX-1 is responsible for the synthesis of these substances. Most NSAIDs interfere with the production of both substances at the same time, leading to the development of peptic ulcers. Amelotex injections do not have such side effects, which is explained by their selective effect.

The anti-inflammatory effect is manifested by a decrease in intensity:

• pain syndrome;
• swelling;
• redness.

The required concentration of the active substance in the blood is detected 10–20 minutes after administration of Amelotex injection solution.
Meloxicam binds to plasma proteins and is distributed to all tissues. Its highest concentrations are achieved in connective tissues. The active substance overcomes the blood-brain barrier, penetrating into the tissues of the brain and bone marrow. Meloxicam enters the fetal circulatory system through the placenta and is excreted in breast milk during lactation. The half-life is 12 hours. The active substance breaks down in the liver, and the end products are excreted by the kidneys. A small portion of meloxicam is excreted through the intestines.

pharmachologic effect

Amelotex is a non-steroidal anti-inflammatory drug that not only relieves inflammation, but also reduces fever and relieves pain. This drug belongs to the oxicam class.

The action of the drug occurs by blocking the release of lactic acid into the tissue. Amelotex is a potent drug, but minimally affects the mucous walls of the stomach.

The drug has an analgesic effect

Analogs

Medicinal drugs such as Movalis and Meloxicam have properties and degrees of impact similar to Amelotex.

The drug "Movalis" was developed in Germany, and its price reaches eight hundred rubles per package. This product is produced in the form of tablets, as well as injections, suspensions and rectal suppositories, like Amelotex. Dosing, as well as the method of using this medication, directly depends on the severity of the patient’s disease.

The advantages of this medicine include the fact that it can be prescribed to adolescents starting from the age of twelve. In addition, the drug acts as an original medicine.

Its unconditional disadvantage is the price, as well as the fact that it cannot be used during pregnancy, during the lactation period, and, moreover, against the background of systematic alcohol consumption.

As for Meloxicam, its price is significantly lower compared to its previous analogue and amounts to no more than three hundred rubles per package. This product is produced in Israel. It is produced in the form of suspensions, tablets, as well as rectal suppositories and injections. It has antipyretic, anti-inflammatory and analgesic effects.

The advantage is, as already noted, low cost. Due to the fact that this medical product has a protective shell, it does not have a noticeable negative effect on the organs of the digestive system.

The downside is a large list of various contraindications along with side effects. Meloxicam negatively affects the health of the liver and kidneys. In addition, there is a high possibility of purchasing a fake.

It's possible, but very carefully

It is noted that in the form of injections, Amelotex can be used for cardiac ischemia, but to minimize the risk of side effects, the drug is prescribed in the minimum possible dosage, and the course is reduced as far as is permissible in a particular case. Similar restrictions are associated with taking meloxicam against the background of cerebrovascular pathologies, diabetes mellitus and disorders of the health and functionality of the peripheral arterial system

Amelotex is used with caution for the treatment of persons who have established cardiac insufficiency in a congestive form; stable creatinine clearance does not exceed 60 ml/min. Similar restrictions are imposed by smoking, dyslipidemia, hyperlipidemia

With caution, patients are allowed Amelotex injections if the person is already of advanced age, has had a stomach or duodenal ulcer in the past, and also in case of infection with Helicobacter pylori

It is necessary to administer Amelotex as carefully as possible if the patient abuses alcohol, takes anticoagulants, hormonal drugs, SSRIs

Drug interactions

Solution for intramuscular administration, suppositories and tablets:

• Other NSAIDs: increases the risk of gastrointestinal ulcers and gastrointestinal bleeding;
• Selective serotonin reuptake inhibitors: the likelihood of gastrointestinal bleeding increases;
• Lithium preparations: the concentration of lithium in the blood plasma increases;
• Intrauterine contraceptives, antihypertensive drugs: their effectiveness decreases;
• Myelotoxic drugs: manifestations of hematotoxicity of Amelotex increase;
• Indirect anticoagulants, thrombolytics (streptokinase, fibrinolysin), heparin, ticlopidine: the risk of bleeding increases (it is necessary to periodically monitor blood clotting parameters);
• Methotrexate: the myelosuppressive effect of the drug increases;
• Cholestyramine: accelerates the elimination of meloxicam;
• Diuretics: increases the risk of developing renal dysfunction;
• Cyclosporine: the nephrotoxic effect of meloxicam is enhanced.

In gel form, Amelotex should not be used simultaneously with other NSAIDs and products intended for external use.

Amelotex's analogs

If replacement is necessary, you can use drugs available in different dosage forms containing the same active substance. It should be taken into account that the side effects of analogues may have some differences from those indicated in the instructions for the drug Amelotex.

Names and forms of release of medicines of similar composition and action:

1. Movalis (solution for intramuscular injections, tablets, suppositories);
2. Meloxicam (tablets and ampoules);
3. Artrosan (tablets and ampoules);
4. Genitron (tablets and ampoules);
5. Liberum (tablets and ampoules);
6. Movasin (tablets);
7. Mesipol (ampoules);
8. Meloflex (ampoules);
9. Mataren Plus (ointment).

All of these replacement drugs also contain meloxicam as an active ingredient, are able to relieve pain at the site of the lesion, and are characterized by anti-inflammatory properties.

Gel Mataren Plus, in addition to meloxicam, also contains an infusion of capsicum. This gives an additional warming effect, but is fraught with side effects.

It is important to note that it is not recommended to select analogue drugs on your own; it is better to do this after consultation with a doctor

Simultaneous use

It was listed above why Amelotex is prescribed: injections of this drug help reduce inflammatory processes. Sometimes the patient needs a combined therapeutic course. When choosing its elements, the doctor must take into account how various medications are combined with each other. In particular, meloxicam, when combined with other non-hormonal anti-inflammatory drugs, is more likely to provoke gastric bleeding and the appearance of ulcerative lesions in the gastrointestinal tract.

If Amelotex is prescribed to people who are forced to take medications to correct blood pressure, it must be remembered that the effectiveness of antihypertensive drugs may become less effective under the influence of meloxicam. When combined with lithium preparations, there is an increased risk of a cumulative effect, due to which lithium will have a more pronounced toxic effect. Methotrexate used in conjunction with meloxicam has a greater risk of causing deterioration in the functioning of the hematopoietic system. If you combine Amelotex and diuretics, cyclosporines, the risk of kidney failure increases. Intrauterine hormonal contraceptives become less effective when using Amelotex.

Patient reviews

Amelotex injections regularly save me. They were prescribed to me because of arthrosis of the knees. I really like that the course is short - only 5 days. The pain goes away very quickly, and the next day it becomes much easier. And the body accepts Amelotex better than Diclofenac - it constantly gave me stomach pain and nausea.

Natalya, 55 years old

I injured my knee during cyclocross, and my leg has been aching ever since. Sometimes the pain was so severe that I could not walk. The doctor prescribed Amelotex and added that you should drink it once a day, preferably after meals.

This is how I take it now: one tablet immediately after breakfast. It only takes a week for the pain to go away and not bother you for another six months. But as soon as the knee makes itself felt, I immediately start a new course.

Christina, 28 years old

I broke my back because of my desire for cleanliness: I was doing some general cleaning and decided to move the closet. But I didn’t wait for my husband. And that’s it, the next day I didn’t get out of bed. After the first injection, the pain began to subside, on the second day I could already move, and on the fifth I forgot about my back.

Galina, 46 years old

Indications for therapy

The use of the drug is recommended only after examination and determination of the cause of the disorders. Most often it is prescribed for the following pathological conditions:

• severe spondylosis;
• osteochondrosis with pinched nerve endings;
• chronic radiculitis with frequent exacerbations and irradiation of pain to the lower extremities;
• arthrosis with damage to large joints and deformation of the limbs;
• rheumatoid arthritis with pronounced clinical manifestations;
• initial stage intervertebral hernia;
• gout in the acute stage;
• bursitis without suppuration in the joint capsule;
• myalgia, myositis;
• polyarthritis with damage to the joints of the feet and hands;
• neuritis and neuralgia of varying etiology and severity;
• vertebral displacement and formation of osteophytes;
• bruises, tendon ruptures, and other injuries without violating the integrity of the skin.

Which is better Amelotex or Meloxicam

Before purchasing, they compare drugs according to the main parameters in order to determine the option that is most suitable for treating the disease. They also pay attention to the cost. Amelotex and Meloxicam are equal in effectiveness, but belong to different price categories. If you need to purchase the product in solid or liquid form, it is better to pay attention to Meloxicam.

For osteochondrosis

For such a disease, you can use solution and tablets. This means that it is permissible to use Meloxicam and Amelotex. Both products can be purchased in solid and liquid form. They do not differ in composition and properties, therefore they act equally effectively for diseases of the musculoskeletal system. However, Amelotex is also available in gel form. A drug for treating the skin in the area where inflammation develops can also be used in the treatment of this disease. For this reason, Amelotex is preferable to consider.

Some facts

The product contains the main component in the form of meloxicam. It refers to therapeutic drugs that have anti-inflammatory and non-steroidal effects during the treatment process. In medicine, it is most often used to relieve pain during the development of arthritis, fever, and various inflammatory conditions in the body.

The material is also characterized by antipyretic and analgesic properties. The action of the component is manifested in the inhibition of prostaglandin compounds after some inhibition of the enzymatic process of cyclooxygenase-2.

When a person uses excess amounts of the drug over a long period, the level of COX2 selectivity decreases. In some cases, the development of ulcerative and erosive formations in the gastrointestinal tract is possible.

Scientific research shows that meloxicam has some effect on cyclooxygenase-1, which is involved in the formation of tissue protection in the digestive system and regulates blood flow in the kidneys.

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How to use

The drug is intended for maximum deep administration into muscle tissue. The daily dosage varies between 7.5-15 mg. There is no need to adjust it if liver cirrhosis is established, but the condition is clinically stable, and also in the case of creatinine clearance more than 25 ml/min. If the patient’s condition is such that the likelihood of developing undesirable effects is assessed above average, it is recommended to begin the therapeutic program with the use of no more than 7.5 mg of the drug per day.

The maximum amount per day is 15 mg of meloxicam. In severe cases of liver failure requiring blood dialysis, it is allowed to use Amelotex in a dose of no more than 7.5 mg per day.

Alcohol compatibility

If the drug is administered together with an alcoholic drink, Amelotex can lead to the formation of ulcers and negatively affect the functioning of the liver. Sometimes, in parallel with this, headaches, fatigue, and weakness occur.

In the case of systematic use of medication and alcohol, bleeding occurs in the stomach. The patient urgently needs to stop drinking strong drinks, take more drinking water, and seek help from a doctor.

The manufacturer's instructions do not indicate anything about the compatibility of this drug with alcohol. You can assume that nothing bad will happen, but it is worth remembering that alcohol can provoke adverse reactions from Amelotex.

The principle of action of the drug "Amelotex" on the body

When it enters the systemic bloodstream in any of the ways (through the skin, the gastrointestinal system, the use of suppositories), Amelotex is able to penetrate the affected cells, and, in addition, to the tissues of the spine and its structure. In this area, a series of chemical reactions are triggered, as a result of which the substance cyclooxygenase-2 is inhibited. This causes a blockade of inflammatory mediators, which are prostaglandins and leukotrienes. This action entails an anti-inflammatory effect.

The antipyretic effect of Amelotex suppositories (15 mg) depends on the blockade of inflammatory mediators, and is also associated with a decrease in the degree of sensitivity of thermoregulation centers in the brain.

The analgesic effect is directly related to the ability of this medication to increase the degree of pain sensitivity, as well as block the pain center in the brain.

Storage conditions and periods

Amelotex should be stored out of the reach of children and out of direct light. The air temperature should be between 8 and 25 degrees Celsius. The product can be used for 2 years from the date of its manufacture.

Gel, suppositories and tablets are stored for 2 and 3 years, respectively, in a dark, dry place, at a temperature not exceeding 25 degrees.

Ampoules under the same conditions, but the temperature should be 8-25 degrees. Ampoules cannot be stored in the refrigerator.

Pharmacokinetics

Well absorbed from the gastrointestinal tract, the absolute bioavailability of meloxicam is 89%. Concomitant food intake does not alter absorption. When using the drug orally in doses of 7.5 and 15 mg, its concentrations are proportional to the doses. Css are reached within 3–5 days. With long-term use of the drug (more than 1 year), concentrations are similar to those observed after the first achievement of Css. The range of differences between Cmax and basal concentrations of the drug after taking it once a day is relatively small and is 0.4–1 mcg/ml when using a dose of 7.5 mg, and 0.8–2 mcg/ml when using a dose of 15 mg. ml (the values ​​of Cmin and Cmax are given, respectively).

Meloxicam penetrates histohematic barriers, the concentration in synovial fluid reaches 50% of the Cmax of the drug in plasma.

Almost completely metabolized in the liver with the formation of 4 pharmacologically inactive derivatives. The main metabolite, 5′-carboxymeloxicam (60% of the dose), is formed by oxidation of an intermediate metabolite, 5′-hydroxymethylmeloxicam, which is also excreted, but to a lesser extent (9% of the dose). In vitro studies have shown that the CYP2C9 isoenzyme plays an important role in this metabolic transformation; the CYP3A4 isoenzyme is of additional importance. Peroxidase is involved in the formation of 2 other metabolites (constituting 16 and 4% of the drug dose, respectively), the activity of which probably varies individually.

It is excreted equally through the intestines and kidneys, mainly in the form of metabolites. Less than 5% of the daily dose is excreted unchanged through the intestines; the drug is found unchanged in urine only in trace amounts. T1/2 of meloxicam is 15–20 hours. Plasma clearance averages 8 ml/min. In elderly people, drug clearance is reduced. Vd is low and averages 11 liters.

Hepatic or renal failure of moderate severity does not have a significant effect on the pharmacokinetics of meloxicam.

In what cases is this pharmacological drug prescribed?

The medication is intended to relieve inflammation and pain that accompany pathologies in the musculoskeletal system.

"Amelotex" gel is indicated for use in the following cases:

1. Ankylosing spondylitis.
2. Osteochondrosis.
3. Bruises, sprains.
4. Deforming osteoarthritis.
5. Diseases of the joints of a rheumatic nature.
6. Arthrosis.

It is important to understand that the components of the gel allow you to get rid of painful manifestations and stop inflammatory foci, but they do not affect the course of the pathology.

As the instructions for Amelotex ointment tell us, contraindications to the use of the drug are:

1. Pregnancy.
2. Lactation period.
3. Violation of the integrity of the dermis.
4. Age up to 18 years.
5. Individual sensitivity to the components of the drug.
6. Polyposis in the nasopharynx.
7. Bronchial asthma.
8. Dermatitis.

Before starting therapy using the medicinal gel, you should consult your doctor. In addition, patients suffering from heart failure, liver pathologies, and stomach diseases should be careful when using the drug.

Use of this medication

In accordance with the instructions for use, Amelotex ointment should be applied exclusively to dry and clean skin. The product can only be used externally and locally. Only those areas of the dermis that do not have scratches, unhealed or open wounds should be treated. Otherwise, it is recommended to stop using the drug.

The procedure for using the medication is as follows:

1. It is necessary to apply a small amount of gel to the skin (a strip up to 3 cm long), and then distribute it evenly over the area.
2. The gel should be rubbed into the epithelium with light movements for 4 minutes.
3. Treatment of joints and back is indicated up to 3 times a day.
4. The optimal time to use the gel is evening and morning hours. The duration of therapy can take 1-4 weeks, unless otherwise recommended by the doctor.

If positive dynamics are not observed during the use of the drug, you should inform your doctor about this. It is strictly forbidden to increase the daily dosage of the medicine on your own.

What are the indications for the use of Amelotex ointment?

Dosage and overdose

The drug must be prescribed by a doctor, as well as the dose of use. Increasing it independently can lead to the development of serious consequences.

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Poisoning with the drug Amelotex usually manifests itself with certain symptoms:

• Impaired consciousness;
• Nausea;
• Vomiting;
• Pain syndrome in the epigastrium;
• Bleeding of the gastrointestinal tract;
• Acute renal failure;
• Stopping breathing;
• Asystole.

There is no special drug to block the action of Amelotex; treatment is symptomatic.

There is no special drug that could neutralize the concentration of the substance in the blood. Thus, experts advise the patient, if he accidentally takes a significant amount of the drug, to urgently seek help from a healthcare professional at the hospital.

Meloxicam, in the form of a gel-like material, slowly penetrates the body. Therefore, an overdose in such cases is practically impossible. If this happened, then an increase in display signs was observed.

When taking an overdose of the drug in tablet form, the following symptoms may develop: • asystology; • dysfunction of the respiratory process; • insufficient functioning of the kidneys and liver; • fainting;

• bleeding in the digestive system. The doctor recommends introducing activated charcoal into the body and urgently going to the hospital for help. The patient should be hospitalized, the stomach should be lavaged, and medications should be prescribed that will eliminate abdominal pain and other signs of poisoning.

Overdose

If a person exceeds the permissible dose, this will increase the possibility of side effects. In case of violation of the conditions of admission, symptomatic therapy is carried out. The product does not have a specific antidote.

If the recommended dosage of Amelotex is exceeded several times, a number of symptoms may develop:

1. disturbance of consciousness,
2. nausea,
3. vomit,
4. epigastric pain,
5. gastrointestinal bleeding,
6. acute renal or liver failure,
7. respiratory arrest,
8. asystole.

If signs of overdose appear during treatment with Amelotex in oral form, gastric lavage should be performed. It is recommended to take activated carbon within the next hour and then carry out symptomatic therapy.

There is no danger of overdose when using Amelotex externally due to the low absorption of meloxicam into the systemic circulation.

It is not recommended to combine Amelotex with drugs of similar action if their main active components are also non-steroidal anti-inflammatory substances. If other forms of meloxicam are prescribed at the same time, for example, tablets, injections, then it is important to ensure that its daily dose does not exceed 15 grams.

Store Amelotex in a dry place, protected from light, out of reach of children. The drug should not be frozen; storage temperature should not be higher than 25 degrees.

Reviews

Attention! The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and give treatment recommendations based on the individual characteristics of a particular patient.

Article updated: 05/22/2019

Patients undergoing treatment note in their reviews that Amelotex:

• quickly relieves pain, the effect lasts for 5-6 hours;
• already in the first days of treatment, swelling is relieved and redness is reduced;
• promotes relaxation of muscles around the painful area;
• the mobility of the diseased joint improves;
• The gel does not burn, but gently warms, does not stick, and does not leave marks on clothes.

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Market Opportunities for Human Health

Often, Amelotex is prescribed to patients if the doctor prescribes Movalis, but its cost is close to a thousand rubles for five doses, so not everyone can afford such expenses. Since Amelotex is based on the same active ingredient, it is what doctors usually offer as an alternative. On average, the price for five doses is about 350 rubles, the specific price tag depends on the pharmacy.

Pointing out the disadvantages of Amelotex, many note that the manufacturer did not consider the presence of a nail file in the package, which would be convenient and safe to open ampoules. In general, dealing with thick medical glass is not easy, especially for those who are forced to open medicine in this form of release for the first time. However, these disadvantages are completely offset by positive qualities - nothing needs to be diluted, the medicine is completely ready for use, and the administration is relatively painless. Persons who have used the product in question advise using syringes with a volume of at least five milliliters for injections, since it is necessary to take a specimen with a very long needle.

Pharmacological properties of the drug

According to the chemical structure, Amelotex is a derivative of enolic acid (class of oxicams) and contains Meloxicam. The pharmacological effect of this compound is associated with the regulation of prostaglandin biosynthesis by suppressing the activity of the enzyme involved in their conversion from arachidonic acid.

The low toxicity of Amelotex is explained by the selectivity of its action. Due to the special structure of the molecule, the active substance acts primarily on COX-2, an isoform of cyclooxygenase that is absent under normal conditions and begins to function as an inflammatory response to tissue damage. At the same time, Amelotex practically does not affect the constitutive isoform of COX-1, which constantly performs physiologically important functions in the body and does not block its normal functioning, i.e. does not disrupt natural regulatory mechanisms.

By inhibiting COX-2, the drug prevents prostaglandins from being synthesized in large quantities in the area of ​​inflammation, accumulating, sending signals to the immune system, transmitting pain and promoting the further development of the inflammatory process.

The instructions inform you that this leads to the following effects:

• anti-inflammatory – the exudation phase is suppressed, increased vascular permeability and the release of exudate into the tissue are eliminated, energy nutrition in the pathological focus is reduced, and the inflammatory process is damped. All signs of inflammation decrease and disappear - joint pain, swelling, redness of the skin in the affected area, tissue swelling that compresses nerve endings and increases the sensation of pain, local hyperthermia. As a result, impaired joint functions are restored and motor activity returns;
• analgesic – the severity and perception of pain decreases without suppressing other types of sensitivity. The effect is due to the ability of Amelotex to influence nociceptors (peripheral pain receptors located on the skin surface and in internal organs), reduce their sensitivity to pain mediators, and interfere with the process of generation and transmission of pain impulses to the brain and spinal cord;
• antipyretic – the elevated temperature associated with a feeling of excess heat, chills, sweating decreases, the normal temperature does not change. The therapeutic effect is achieved incl. due to the suppression of the activity of pyrogens, which raise temperature settings in the hypothalamus - the main center of thermoregulation.

When will it help?

The use of Amelotex in injections is recommended for people suffering from osteoarthritis and ankylosing spondylitis. The drug is prescribed to relieve rheumatoid arthritis. Meloxicam helps improve the condition of patients who have degenerative, inflammatory lesions in the joint area, and such areas have become the cause of severe pain.

The manufacturer notes: “Amelotex” is designed for symptomatic treatment. The drug is able to stop the inflammatory process and relieve pain

It does not in any way affect the course of the disease and cannot be considered the main medicine for its treatment. The diagnosis does not matter.