Detralex for hemorrhoids: reviews, instructions for use, analogues

Release forms, composition

Detralex hemorrhoid tablets are produced in France, in blisters of 10 pieces, packaged in cardboard packs with a first-opening control system. This is the only pharmacological form of the drug. The drug is not available in suppositories or liniments. Detralex tablets belong to the group of venotonics (phlebotonics), eliminating the main cause of hemorrhoidal disease - weakness of the veins. The drug is extremely effective for the treatment of hemorrhoids of different locations.

The effectiveness of Detralex is related to its composition. The preparation contains five bioflavonoid components. These are natural plant polyphenols:

• Diosmin solves the main problem - balancing venous tone, including in patients who have a hereditary predisposition to venous weakness. Due to the angioprotective properties of the substance, vascular permeability decreases and microcirculation of varicose cavities improves. Diosmin affects the absorption of norepinephrine, a hormone that has a vasoconstrictor effect, which actively prevents varicose veins. In the States it is sold as a dietary supplement.
• Hesperidin from lemon or red pepper peel potentiates diosmin, enhances its qualities, protects veins from inflammatory exudate, and reduces tissue pastosity.
• Diosmetin is a bioflavonoid, a diosmin aglycone (devoid of carbohydrates in its structure), which has antitumor activity and can block the proliferation of epithelial cells and the growth of hemorrhoids.
• Linarine is an alkaloid from toadflax, which stimulates bile synthesis, improves intestinal motility, and facilitates bowel movements.
• Isoroifolin – improves the reparative abilities of tissues of the anorectal area.

The maximum concentration in Detralex is reached by diosmin and hesperidin, which provide the main therapeutic effect of the drug. This is the only phlebotropic drug that contains purified plant bioflavonoids in microform. The maximum reduction in particle size of the active fraction guarantees rapid absorption after oral administration, that is, an almost instantaneous therapeutic effect with an efficiency of 100%.

Vacation conditions and cost

The drug Detralex is an over-the-counter drug and is therefore offered for free sale. Its cost depends on the number of tablets and dosage:

• For 30 pieces of 500 ml of active substance in Moscow you need to pay from 820 to 855 rubles.
• For a package of 10 tablets with a dosage of 1000 ml - from 716 to 820 rubles. To save money, it is better to purchase a box of 30 pieces of 1000 ml at a price of 1344–1500 rubles.

For the convenience of patients, the manufacturer has developed a Detralex suspension. It has a similar composition and light taste, does not require stirring in water or complex preparation. Compact sachets can be taken on a trip and are easy to dose. The cost of the drug in this form is 740 rubles for 15 units or 1,440 rubles for a complex of 30 units.

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Properties of Detralex

Treatment of hemorrhoids with Detralex is aimed at relieving negative symptoms and preventing chronicity of the pathological process. There are no gender differences in its use; the drug is equally effective for the treatment of hemorrhoidal disease in men and women. The essence is the normalization of blood flow in the anorectal area against the background of a general balancing of venous circulation in the body.

The properties of a venotonic and angioprotector allow the drug to reduce the distensibility of veins, normalize venostasis, improve lymphatic drainage, and increase the resistance of blood vessels to negative influences. Detralex blocks the adhesion of leukocytes to the vascular endothelium, which reduces the deforming effect of inflammatory mediators on venous valves.

The advantages of Detralex among analogues in terms of composition and mechanism of action include:

• multi-vector, multi-directional therapeutic effects, since flavonoids enhance each other (the effect of the transition of quantity into quality), prolong the duration of the therapeutic effect;
• the speed of achieving the planned result due to the nanostructure of the active substances (it is no coincidence that Detralex is used in the postoperative period, where maximum speed of pain relief, prevention of inflammation, and pastosity are necessary);
• complex effect on vein tone, vascular permeability, regeneration and recovery processes, blocking the progression of hemorrhoids at different stages of development, preventing the formation of new nodes.

Composition and properties of the drug

The pharmaceutical product Detralex contains a complex of five bioflavonoids, which are natural plant polyphenols: diosmin, hesperidin, diosmetin, linarin, isorhoifolin. However, in percentage terms, the largest share is occupied by the first two components, which determine the therapeutic effect of the drug.

What are the advantages of this medicine? Official manufacturers indicate the following strengths:

• complex action. Flavonoids complement and enhance each other’s effects, thereby increasing the effectiveness of the therapeutic course;
• quick effect. A special technology - micronization - allows you to create medicines consisting of tiny particles. Consequently, the drug is very quickly absorbed through the gastric walls and exhibits healing properties;
• triple action, which consists of increasing venous tone, reducing vascular permeability and restoring their stability, as well as preventing further progress of hemorrhoidal disease.

To fully understand the pharmaceutical properties of Detralex tablets, you should carefully study the qualities of its main active ingredients - diosmin and hesperidin.

This element gives elasticity and firmness to the vascular walls, strengthens them, which, accordingly, improves blood circulation and reduces the intensity of the inflammatory process. And the angioprotective qualities of diosmin make it possible to reduce the permeability of capillary membranes, which helps improve microcirculation in cavernous formations.

Hesperidin, obtained from lemon peel, is designed to enhance the therapeutic effect of diosmin due to the ability to strengthen the vascular membranes and increase their resistance to inflammatory exudate. As a result, veins and capillaries are less susceptible to external irritants, local blood circulation improves, inflammation is eliminated, and swelling is reduced.

Indications

According to the instructions for the drug, the use of Detralex for hemorrhoids increases hemodynamic parameters with impaired venous outflow. Therefore, its main purpose in complex treatment is:

• chronic venous insufficiency, including genetic ones;
• hemorrhoidal disease of any location, form, stage, severity;
• the appearance of the first symptoms of hemorrhoids due to physical inactivity and a sedentary lifestyle;
• itching, irritation, dermatitis, eczema of the anus;
• blood in the stool;
• periodic prolapse of hemorrhoids, which are reduced into place independently or by the patient’s hands (unreducible, advanced version of hemorrhoids requires the use of tablets during preparation for and after surgery)

Factors that provoke hemorrhoidal disease include:

• pregnancy;
• constipation;
• strength sports;
• alcoholism, smoking, drugs;
• overeating, predominance of salty, smoked, canned foods in the daily diet;
• inflammation of the pelvic organs.

If at least one of them is accompanied by hemorrhoidal symptoms, a consultation with a proctologist is necessary. The sooner Detralex is used for treatment, the greater the chances of complete relief of the disease without surgical intervention.

Side effects

According to the instructions, Detralex is well tolerated in the treatment of hemorrhoids. Negative symptoms are rarely possible, which do not require discontinuation of the drug, but only dose adjustment.

From the gastrointestinal tract:

• dyspepsia;
• diarrhea;
• constant nausea;
• vomit;
• epigastric pain;
• inflammation of the large intestine.

From the nervous system:

• migraine;
• dizziness;
• weakness, weakness;
• sometimes prodrome phenomena.

From the skin, mucous membranes:

• rashes;
• hives;
• allergic dermatitis;
• tissue pastiness;
• angioedema.

Such manifestations do not carry any serious consequences, only a feeling of discomfort. But contacting a doctor is necessary, since a dose adjustment or drug replacement is necessary so that the quality of life is not impaired.

Detralex for hemorrhoids: dosage regimen

According to the instructions, the optimal effect of taking Detralex for chronic hemorrhoids is 2 tablets/day at a time. It has been experimentally proven that the drug is almost completely metabolized, excreted through the intestines (up to 80%) and in the urine (15%). The course of therapy with Detralex, the dosage is calculated by the doctor individually, taking into account the form, stage, severity of hemorrhoids, the general condition of the patient, and his age. On average, this is a week, but can last up to three months. There is an option when taking the drug is divided into two doses: morning and evening.

For acute hemorrhoids, Detralex is prescribed immediately in a loading dose: 6 tablets, divided into two doses. This is a treatment regimen for hemorrhoids of any location for the first 4 days. Over the next three days, the dose of the medicine is reduced to four tablets in two doses. Drink the drug during meals so as not to irritate the gastric mucosa. The first result is obvious within 12 hours after the first intake of the tablets. Treatment is carried out in a short course under the supervision of a doctor.

In case of exacerbation of hemorrhoids, treatment with Detralex does not replace specific therapy for other diseases of the anorectal area.

Instructions for use of the drug

As a result of the studies, the dose-dependent therapeutic effect of the drug Detralex was confirmed, therefore it is recommended to take the medicine at a dosage of 1000 mg per day. A decrease in the amount of active substance leads to a decrease in the effectiveness of treatment.

The half-life of the drug Detralex is 11 hours, but no dependence of the treatment result on the dosage regimen during the day has been identified. The instructions for the medication recommend taking Detralex at a dose of 1000 mg after meals.

Changing the dosage regimen with increasing the amount of medication taken is allowed in case of acute hemorrhoids or in case of exacerbation of a chronic process.

For hemorrhoids, the following regimen for taking the drug Detralex has been developed: in the first 72 hours of an acute condition, 3000 mg per day is prescribed in 2-3 doses, for the next three days, 2000 mg per day in 2 doses. Then they switch to daily use of 1000 mg per day.

To prevent exacerbations, it is recommended to take 2 tablets of 500 mg or 1 tablet of 1000 mg for a long time. How long to take Detralex is decided by the attending physician, who will assess the degree of damage to the veins due to hemorrhoids, the presence of concomitant pathologies and factors for the progression of venous insufficiency.

The course of treatment with Detralex is at least 6–7 days for an acute process and, according to indications for chronic hemorrhoids, can be extended to 1 year. The duration of treatment recommended by experts is 3–6 months. Repeating the course is possible on the recommendation of a doctor.

The therapeutic effectiveness of the drug increases with an integrated approach to treating the disease. The combination of Detralex with topical medications accelerates the restoration of the tone of hemorrhoidal veins and trophism of the affected tissues, enhances the anti-inflammatory and analgesic effect, and prevents the development of hemorrhoidal bleeding.

In addition to drug therapy, the patient requires lifestyle changes:

1. Healthy eating. It is recommended to enrich the daily diet with difficult-to-digest carbohydrates, vitamins, proteins and fiber. It is advisable to limit the consumption of fatty foods. Sufficient drinking and proper diet will help avoid constipation. At the same time, the diet corrects increased weight, which increases blood pressure in the veins of the pelvis and lower extremities.
2. Dosed physical activity. They have a beneficial effect on vascular tone and motility of the gastrointestinal tract. Your doctor may recommend going to the pool or doing physical therapy. Prolonged static loads and heavy lifting, on the contrary, contribute to stagnation of blood in the hemorrhoidal vein system; such loads must be completely avoided during an exacerbation.
3. Maintaining hygiene rules. Inflammatory phenomena in the area of ​​the hemorrhoidal plexus and anus intensify as a result of infection, so toileting the genitals after defecation is a necessary element of treatment. Traumatization of the mucous membranes during anal sex promotes the inflammatory process and increases the risk of infection.

Detralex during pregnancy, breastfeeding

The naturalness of the product makes it possible to prescribe Detralex to pregnant women if necessary. Moreover, numerous clinical experiments have not revealed the teratogenicity of the drug. However, by default, any drug during pregnancy is considered contraindicated, since there is no guarantee of its inertness towards the fetus. Therefore, doctors recommend the use of Detralex for hemorrhoids in pregnant women, starting from the third trimester.

Due to the lack of data on the excretion of the drug in milk, breastfeeding during the use of Detralex is not recommended.

Components and mechanism of action of the drug

The drug is produced by a French pharmaceutical company in the form of 500 mg tablets (450 milligrams of diosmin, 50 milligrams of hesperidin and additional substances).
They have a pinkish and orange tint, and are light yellow inside. They are packaged in plastic blisters of fifteen pieces, one pack contains 30 or 60 capsules and instructions for use. Proctologists often prescribe Detralex tablets for hemorrhoids, since the elements included in the composition have a venotonic and decongestant effect, which helps normalize blood flow, reduce swollen nodes, and strengthen vascular walls.

Diosmin

It is an angioprotector, reduces vascular permeability, strengthens and tones them, which reduces swelling and pain. Stimulates the outflow of lymph from inflamed nodes, fights blood stagnation and normalizes its microcirculation.

Hesperidin

Strengthens capillary walls, improves their tone, enhances the activity of the main active ingredient. Relieves symptoms of burning and itching, minimizes the risk of bleeding.

Detralex tablets for hemorrhoids have a unique feature that distinguishes them from their analogues: the substances they contain are in micronized form, which significantly increases the rate of absorption in the gastrointestinal tract and the effectiveness of the effect.

Drug interactions

No symptoms of Detralex overdose were recorded during the entire clinical observation period. But the potential possibility of such intoxication cannot be excluded. In this case, it is necessary to rinse the stomach, take an adsorbent (activated carbon, Filtrum), and consult a proctologist.

Detralex for hemorrhoids is inert in relation to other drugs, which makes it the drug of choice in the complex treatment of hemorrhoidal disease. Despite this, venotonic tablets have their own characteristics that should be taken into account when treating the disease:

• the maximum effect from using Detralex is possible only when combined with external medications;
• the duration of treatment (especially at home) must correspond to the time limits specified in the instructions for one or another form of the disease: the lack of results after this period is not a reason for extending the time period, but the need to consult a doctor;
• tablets of the drug should be combined with diet therapy, an active lifestyle, and constant monitoring of bowel movements.

Overdose and therapeutic interaction

Clinical trials have not revealed symptoms of overdose when using the drug Detralex. But if the patient has taken too many tablets, it is recommended to rinse the stomach, take activated charcoal or another sorbent and consult a doctor.

In medical practice, cases of therapeutic interaction of the drug with other pharmaceuticals have not been described. But it is still recommended to inform a specialist about the use of other medications for the treatment of hemorrhoids.

Analogs

In the Russian Federation there is a complete synthetic analogue of Detralex - this is Venarus. Venotonic based on the flavonoids diosmin and hesperidin, has angioprotective properties, costs 490 rubles. This is a generic drug that began to be produced in Russia after the patent of the French company expired. The product has passed all the necessary clinical trials and has an identical active component to the one patented by the company - the original developer of the drug.

In addition, many drugs are analogues of Detralex in composition and mechanism of action:

• Venozol - capsules contain the same bioflavonoids as Detralex, but are supplemented with other plant extracts, so in fact they are not considered drugs, but dietary supplements. However, they have a significant tonic effect on the veins of the anus and rectum, stimulate bowel movements, relieve inflammation, and pain from hemorrhoids (50 rubles).
• Dioflan is an effective remedy for oral use, which has a venotonic and angioprotective effect in hemorrhoidal pathology (540 rubles).
• Daflon is an angioprotector, phlebotonic for the symptomatic treatment of hemorrhoids and chronic venous diseases. Relieves pain, heaviness in the legs, cramps, swelling. The drug is one of the few effective for acute hemorrhoidal attacks, which makes it the drug of choice in case of emergency care.
• Venolek is a drug based on diosmin, used to treat varicose veins in various areas of the body, including the anorectal zone, relieves pain, inflammation, and increases the tone of the veins (470 rubles).
• Phlebodia 600 - capsules with a vascular tonic effect, are responsible for microcirculation of the anorectal area, restore the valves of the veins of the lower extremities (800 rubles).
• Vasoket is a venotonic based on the flavonoid diosmin with angioprotective, vascular wall restoration, and anti-inflammatory properties. Reduces the size of hemorrhoidal cones (600 rubles).
• Antistax is a phlebotonic drug based on grape leaf extract, used for the simultaneous treatment of hemorrhoidal disease, varicose veins, and venous insufficiency (580 rubles).
• Pilex - the medicine is based on purified mumijo, other, exclusively natural components that give the drug special properties: venotonic with anti-inflammatory, anti-edematous, analgesic effect during the formation of hemorrhoidal cones. Stimulates defecation. Indicated for the prevention of hemorrhoids of any form (600 rubles).
• Chemoroidin - capsules based on inulin from chicory, gingko biloba, prevent thrombosis, relieve inflammation, exhibit phlebotonic properties. Feature: complete absence of side effects. Indicated for hemorrhoids of any location (600 rubles).
• Troxevasin is a drug based on rutin. A good antioxidant that reduces inflammation and rejuvenates blood vessels. Increases the tone of the veins, improves microcirculation of the rectum and anus, relieves swelling, inflammation, pain (300 rubles).
• Troxerutin is another venotonic based on rutin: an angioprotector with P-vitamin activity for hemorrhoidal disease (330 rubles).
• Ascorutin is a combination of the flavonoid rutin and ascorbic acid. Restores vitamin C and P deficiency and exhibits angioprotective properties. A derivative of the drug - Ascorutin D - for diabetics (contains sorbitol instead of sugar). The product is used to treat hemorrhoids at any stage (40 rubles).
• Venoruton is a synthetic derivative of rutin based on hydroxyethylrutoside. It has a phlebotonic, angioprotective effect on the veins and capillaries of the rectum, relieves cramps, swelling, pain, and participates in the complex treatment of hemorrhoids (300 rubles).
• Venoprotect – Doppelhertz active. The combined venoprotector has antispasmodic properties, normalizes microcirculation in the anorectal area, and restores vascular elasticity (350 rubles).
• Normaven is a rutin-based dietary supplement that normalizes venous outflow, increases the tone of the veins of the rectum and anus, affecting the condition of vascular valves (385 rubles).
• Cyclo 3 forte capsules are an angioprotector based on hesperidin, reduces capillary permeability, affects lymphatic vessels, improves microcirculation of hemorrhoidal cavities (620 rubles).
• Vazonit - tablets based on pentoxifylline, dilate blood vessels, improve nutrition, oxygen supply to rectum tissues, prevent thrombosis of hemorrhoids (350 rubles).

Replacing Detralex tablets for hemorrhoids with analogues is the prerogative of the doctor.