Mezim forte for pancreatitis for the pancreas

What is the difference between Mezim and Festal?

There are contraindications, consult a specialist.
Mezim is a well-known German enzyme preparation, presented in three forms: Forte, 10000, 20000 (20 or 80 pieces per package). The difference between them is only quantitative and is determined by how many enzymes are in one tablet. Thousands are international units that measure the effectiveness of lipase, the main enzyme responsible for the breakdown of fats. The higher this indicator, the “stronger” the drug.

In addition to lipase, Mezim contains protease (protein breakdown) and amylase (carbohydrate breakdown). Their activity is also measured in units, but since pancreatic secretory insufficiency is primarily manifested by lipase deficiency, the gradation of pancreatin preparations according to their potency is indicated by lipase units.

Mezim Forte – 20 tablets

The French Festal also contains these enzymes, there are more of them than in Mezim Forte, but less than in Mezim 10 and 20 thousand (see comparative table below). Available in 20, 40 or 100 tablets. The main difference between Festal and Mezim is the presence of bile and hemicellulase components in each tablet. This addition ensures a more comprehensive participation of the drug in the digestion of food.

1. Components of bile

   :

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   • enhance lipase activity in the breakdown of fats,

   moderately enhance the contractility of the gallbladder during dyskinesias,

2. Helps absorb fat-soluble vitamins
3. have a slight laxative effect due to increased intestinal motility.
4. Hemicellulase
   is an enzyme responsible for the breakdown of plant fiber in the intestines. In a healthy person, this substance is produced in sufficient quantities by the natural microflora. When there is a disturbance in the normal flora or a deficiency of this enzyme, fermentation processes begin, manifested in excess gas formation and flatulence. The amount of hemicellulase in one Festal tablet is not so large as to ensure complete replacement of its deficiency in case of intestinal problems; one can only count on an auxiliary effect.

Composition of Festal and Mezim - comparison

What to choose?

Both drugs have been used in gastroenterology for a long time and have proven themselves well. When choosing between Festal or Mezim, it is better to proceed from the diagnosis made by the doctor. Mezim 10,000 or 20,000 is best used for long-term systematic treatment, for example, for chronic pancreatitis, selecting the desired dosage of tablets. Mezim Forte or Festal is taken individually or short-term to help digestion. Festal is also advisable in the presence of JPV (hypokinetic type), during diets that require an increased amount of plant fiber in the diet (greens, bran, vegetables), and for constipation associated with poor nutrition.

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How to prescribe

As a rule, Mezim is prescribed in the amount of one or two tablets before meals. But again, the dosage depends on the patient’s weight, and it must be determined by the doctor. The same as the dosage for children. As a rule, they are not prescribed for children under three years of age. The drug is also not recommended for pregnant women. You need to take these tablets with plenty of clean water.

Which is better: “Mezim” or “Pancreatin” or “Creon”, it can be very difficult to decide.

Side effects of this medication may include diarrhea, nausea, vomiting, and increased urea levels.

This drug is effective in the treatment of both mild and serious forms of gastrointestinal disorders, since the content of the active substance in it is increased.

special instructions

Before using the drugs, you must study the special instructions listed by the manufacturer:

1. In people suffering from cystic fibrosis, taking pancreatin (especially in high doses) can lead to the development of hyperuricosuria. Therefore, with this diagnosis, it is necessary to monitor the level of uric acid in the urine.
2. If unusual discomfort appears in the abdomen during therapy, you should consult a doctor for a medical examination. The same must be done if the nature of the complaints changes.

Pregnancy and lactation

In medicine, there is no data on how enzyme medications affect the condition of pregnant and lactating women. Therefore, drugs are rarely prescribed during lactation and pregnancy. The doctor must be sure that the treatment will bring more benefit to the patient than harm.

Childhood

The drugs are used to treat children over 3 years of age.

The treatment regimen is prescribed by the pediatrician depending on the diet and the severity of digestive disorders. The maximum permissible daily dose is 10,000 units of lipase per 1 kg of body weight. If there is no improvement, existing symptoms worsen, or new ones appear, the child should be shown to a doctor.

Mezim Forte is used to treat children over 3 years of age.

Dosage

The dosage of the drug is calculated based on the stage of the disease, the severity of its course and the age of the patient.

Adults are usually prescribed 1 or 2 tablets per day. However, in cases where there is significant dysfunction of the digestive tract, the daily dose of the drug is increased to 4-6 tablets. In some cases, it becomes necessary to take a loading dose of the drug, but it should not exceed 12 tablets per day.

Children and adolescents from 7 to 12 years old are allowed to take up to 1500 IU per kilogram of body weight per day.

Adolescents from 12 to 18 years old can take up to 2000 IU per kilogram of body weight per day.

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Pharmacological properties

Pharmacodynamics

Pancreatin Forte is a digestive enzyme preparation that has proteolytic, amylolytic and lipolytic effects. By compensating for the insufficiency of the secretory function of the pancreas, it helps to improve the digestion of food. Pancreatic enzymes (lipase, trypsin, alpha-amylase, chymotrypsin) are involved in the processes of biotransformation of fats to glycerol and fatty acids, proteins to amino acids, starch to dextrins and monosaccharides.

As a result of improving the breakdown of plant fiber, the enzyme hemicellulase helps reduce the formation of gases in the intestines.

The analgesic effect of the drug is due to the suppression of stimulated pancreatic secretion by trypsin.

Pharmacokinetics

After oral administration, the maximum activity of pancreatin is achieved within 30–45 minutes.

The enteric coating protects pancreatic enzymes from the acidic environment of gastric juice; their release occurs in the alkaline environment of the small intestine.

Contraindications to the use of Mezim

The drugs cannot be used in case of individual intolerance to the constituent substances, acute pancreatitis, exacerbations of chronic pancreatitis. Conditions such as hereditary galactose intolerance and glucose-galactose malabsorption syndrome are also contraindications.

The drugs contain components that interfere with the full absorption of iron, so the dose can be increased only with the approval of a doctor. Failure to comply with this requirement is fraught with the development of iron deficiency anemia. If long-term treatment is indicated, you should discuss with your doctor the issue of prescribing iron supplements.

Release form and composition

The drug is produced in the form of enteric-coated tablets: brown or dark brown, round, biconvex, with a specific odor (20, 30 or 60 pcs. in dark polymer/glass jars, 1 jar in a cardboard pack; 10 pcs. . in blister packs, in a cardboard pack of 2, 3 or 6 packs and instructions for use of Pancreatin forte).
1 tablet contains:

• active ingredient: pancreatin with the following enzyme activity: amylase - no less than 4620 units (unit of action), lipase - no less than 3850 units, protease - 275-500 units;
• auxiliary components: sodium carboxymethyl starch (Primogel), microcrystalline cellulose, pregelatinized starch (starch 1500), povidone (low molecular weight medical polyvinylpyrrolidone), colloidal silicon dioxide (Aerosil), magnesium stearate;
• shell composition: Tween-80 (polysorbate), cellacephate (cellulose acetylphthalyl), vaseline oil (liquid paraffin), brown iron oxide (ferronate E172 or sikovit 70 E172).

Mezim brief description

The enzyme preparation Mezim is available in the form of dragees or enteric-coated tablets. In pharmacies the drug is sold in packs of 20 or 50 pieces. The medicine is produced by the largest German pharmacological company. Country of origin: Germany. The price of one Mezim blister is 66-78 rubles, which is significantly lower than the cost of a similar pack of Festal tablets.

The basis of this drug is the biologically active substance pancreatin and powder from the pork pancreas. Mezim also contains cellulose, polysorbate, sodium hydroxide and magnesium stearate.

Mezim is prescribed for replacement therapy for disorders of the exocrine activity of the pancreas, chronic pancreatitis, mucoviscidosis, chronic inflammatory-dystrophic diseases of the stomach, intestines, gall bladder and liver.

The drug is also indicated for patients who have undergone surgery or radiation therapy of the digestive system. At the preparatory stage for ultrasound and fluoroscopic examinations. Occasionally, Mezim is used for overeating.

The reasons for refusing drug therapy for this enzyme agent may be:

• hypersensitivity of the body to the digestive enzymes lipase, amylase, protease, trypsin and auxiliary components of the drug;
• attacks of acute and chronic pancreatitis;
• intestinal obstruction.

Read more here: Indications for use of Mezim, instructions.

When to use

Enzyme preparations are prohibited during periods of acute pancreatitis or exacerbation of chronic forms. Mezim is no exception, as it is a prominent representative of enzyme preparations.

The purpose of this remedy is to relieve the burden on the pancreas and other organs of the digestive tract. If you take Mezim during an exacerbation of pancreatitis, the patient’s condition can only worsen, since the enzymes in the drug do not help reduce pancreatic juice, but also help it work. This process further irritates the gland and does not contribute to the normalization of the patient’s condition.

Diseases of the pancreas are often accompanied by diseases of the gallbladder. The most common is inflammation of the gallbladder or cholecystitis.

This disease can be caused by various reasons:

• stones in the kidneys;
• complication of diabetes;
• infections;
• pregnancy;
• excessive consumption of fatty and spicy foods;
• large doses of alcohol.

For pancreatitis and cholecystitis, enzyme preparations help normalize gastrointestinal motility.

Just as in the case of inflammation of the pancreas, self-medication with cholecystitis is strictly prohibited. At the slightest hint of this disease, you should urgently consult a doctor.

What the reviews say

We studied the reviews that people left on websites where these medications are sold and on forums. Debates about the benefits of one of these two drugs are very common, but the main conclusions are as follows:

• Some users highlighted the cost of “Pancreatin” as an undeniable advantage of this drug.
• Some wrote that they encountered side effects when using this medicine - it made them feel sick.
• On medical forums, experts spoke of Pancreatin as a drug with very weak effects;
• "Mezim", judging by the reviews, is more effective - this was written by users who tried both drugs.
• The high price of Mezim often makes it inaccessible to people with low incomes who suffer from chronic diseases for which this drug is indicated.
• On medical forums, doctors noted its higher effectiveness compared to Pancreatin.

Which is better: “Micrazim”, “Mezim”, “Pancreatin”, it’s up to you to decide.