Longidaza instructions for use, description of the drug

Adhesions are cellular growths. They are often compared to threads, as they connect organs and tissues to each other, for example, the intestines, uterus and peritoneal surface, rectum and cervix. These “threads” contain blood vessels and nerves. Even the physiological movement of organs causes tension on the adhesions and pain. In addition, the adhesive process can “close” the lumen of the fallopian tubes and cause infertility. Such threads can form in any part of the genital organs - the uterine cavity, cervical canal, vagina.

pharmachologic effect

The drug has a prolonged enzymatic proteolytic effect.
Prolongation of action occurs due to the covalent binding of longidase to a high molecular weight, active carrier (poly-1,4-ethylenepiperazine N-oxide derivative), which has pharmacological activity. The covalent bond ensures the enzyme's resistance to destructive reactions and the action of inhibitors, as well as the immediate local presence of a carrier and a hydrolytic enzyme that binds enzyme inhibitors and activators of collagen synthesis (copper, iron, heparin ions). That is why Longidase is able to depolymerize the connective tissue matrix in fibrous-granulomatous structures, as well as suppress the regulatory reaction necessary for the synthesis of structural units of connective tissue.

Glycosaminoglycans such as chondroitin, hyaluronic acid, chondroitin-4 and -6-sulfate are specific substrates of testicular hyaluronidase. They form the basis of the connective tissue matrix. As a result of depolymerization under the influence of hyaluronidase, substrates lose their properties, such as the ability to bind water, viscosity, etc. The conversion of collagen protein into fiber also becomes more difficult, the permeability of tissue barriers increases, the movement of fluid between cells improves, and ultimately the elasticity of connective tissue improves.

Longidase helps reduce the manifestations of the acute phase of inflammation, affects the synthesis of mediators of the inflammatory response, increases infection resistance and increases the tension of humoral immunity.

Pharmacokinetics

When administered parenterally, it quickly enters the systemic circulation, reaching maximum concentration within 20-25 minutes. It is quickly distributed throughout tissues, penetrates into all organs and structures, including the brain, but does not accumulate.

When administered rectally and vaginally, it also quickly enters the bloodstream, reaching a maximum concentration after 1 hour. The bioavailability of suppositories is 70%. Excreted by the kidneys (half-life is 42-84 hours). Metabolized to low molecular weight oligomers.

Composition and properties of Longidase

The main active component of the drug is longidase, which is a combination of the enzyme hyaluronidase and a special carrier substance. This combination makes it possible to increase the resistance of the enzyme to destructive factors, make its action longer and thereby increase the effectiveness of the treatment, which significantly distinguishes the drug from other products containing hyaluronidase.

In general, the drug Longidaza has the following positive properties:

• acts as an antioxidant
• enhances local immune responses
• characterized by a moderate anti-inflammatory effect
• facilitates microcirculation of fluid in the intercellular space
• enhances the removal of toxic substances from tissues
• helps reduce the severity of adhesions in the pelvic organs

The drug acts only on pathologically altered tissues of the body, does not accumulate in them, is well tolerated, does not have teratogenic, carcinogenic or embryotoxic effects, does not cause progression of infectious processes and is suitable for use in the postoperative recovery period.

Known analogues

There are no drugs with identical active substance and effectiveness.

A similar (but not analogous) therapeutic effect is exerted by:

Lidase - the active ingredient is hyaluronidase - a natural enzyme obtained from the glands of cattle, which has not undergone special treatment (unlike Longidase). It does not have a prolonged effect (injections need to be administered more often) and additional properties - antioxidant and immunomodulatory. Can be prescribed during pregnancy and lactation. The cost of 10 ampoules is about 300 rubles;

• Polyoxidonium. The active ingredient is azoximer bromide, additionally containing mannitol, povidone and beta-carotene. The basic effect is immunomodulatory. The drug is used for tuberculosis, chronic and recurrent urogenital diseases. Polyoxidonium is approved for children from six months of age; it is contraindicated for pregnant and lactating women. The price of 10 ampoules (minimum course) is about 1000 rubles;
• Chymotrypsin. The drug contains an enzyme from the pancreas of animals. Scope of application: inflammation of the gums, ENT diseases, inflammatory processes in the lungs and organs of vision. Chymotrypsin is not prescribed until age 18, during pregnancy and lactation. The price of 10 ampoules is about 800 rubles;

Trypsin - similar in composition to Chymotrypsin, is used for pulmonary, eye and ENT diseases, including purulent inflammation and in the postoperative period. The drug resolves scars and liquefies viscous pus. Trypsin can be administered to pregnant and lactating women. Price – 800 rubles for 10 ampoules.

All of the listed medications can be purchased in powder form for the preparation of an injection solution.

Longidaza suppositories for prostatitis: special instructions

The drug can be purchased in pharmacies with a doctor's prescription.

Storage conditions

Longidaza suppositories are stored at a temperature no higher than +15 degrees; it is preferable to store them in the refrigerator.

Otherwise, if the temperature is above 16 degrees, the drug will deteriorate, and if the suppositories have softened, it will be problematic to administer them. The medicine must be securely hidden from children.

Best before date

If the specified storage conditions are met, the drug can be used for up to two years.

special instructions

If an allergy occurs, the patient must stop taking the medicine. Longidaza suppositories for prostatitis are prescribed in combination with other drugs. If it is necessary to take medicine during an exacerbation of the infection, then in addition to the main drug, antimicrobial agents are prescribed. If the expiration date has expired, the color of the suppositories has changed, or if there are visible violations of the packaging, the medicine should not be taken.

If the patient missed one dose of the drug, that is, did not administer the suppository on time, then the medicine is used as usual; a double dosage should not be taken. If it is necessary to stop taking Longidaza, this can be done immediately without gradually reducing the dosage. Studies have shown that the drug Longidaza does not affect the ability to drive, and it does not reduce concentration.

Analogs

Ronidase is a drug prescribed for the healing of scars caused by burns, surgeries or injuries. The remedy is also used for ulcers that do not heal for a long time, for hematomas, allergic rhinitis, in case of nerve plexus injury, and for keratitis.

Polyoxidonium is an immunostimulating drug that enhances the body's resistance to infections of any origin. Prescribed for the treatment of chronic diseases of the respiratory system, ENT organs, and pelvic organs caused by microbes. The drug is used for complex treatment of many diseases, including the treatment of infections that have entered the body after surgery, as well as for the treatment of allergies, tuberculosis, dysbacteriosis, arthritis, and trophic ulcers.

Cystamine is a drug prescribed after a person has received radiation therapy, as well as to destroy pathogenic microorganisms that cause various diseases. The product is used to heal scars and cuts, including promoting the healing of scars formed during operations. In addition, the drug increases the body's resistance to harmful environmental influences.

Lidaza M - a medicine that helps to quickly heal wounds resulting from burns, injuries, radiation ulcers, and scars. The drug helps relieve inflammation in the organs of the upper respiratory tract, in the joints and restore their mobility; it is prescribed for pulmonary tuberculosis, neuritis, and pleurisy.

Reviews

Olga, 36 years old “I had surgery on the ovary, there was a laparoscopy. Now a scar has appeared in this place, the doctor prescribed me Longidaza suppositories, I will say right away that they are very expensive for me personally, about 1,400 rubles, they are not sold in every pharmacy, I went to the ends of the universe for them. The effect of the drug was expected and pleasant, after three weeks the scar was almost completely hidden. The drug is attractive because it also helps against many diseases. Sometimes, for the sake of your health, you can buy an expensive drug.”

Irina, 41 years old “I used the drug Longidaza in combination with Milgamma and Lidocaine injections. I was diagnosed with salpingitis in a chronic form, so I was treated, it seemed to help, my specialist said that I was on the mend, that of these remedies it turned out to be better, I don’t understand, although everyone seems to say that Longidaza is doing its job.”

Ilya, 51 years old “I took Longidaza suppositories for prostatitis, but in addition to this, they also prescribed me a bunch of pills. The effect is not bad, the drug is worth the money.”

Price, where to buy

The drug in the form of a suppository costs from 1300 to 1500 rubles in Russian pharmacies. The price, first of all, depends on the manufacturing company, the city and the supplier. Longidaza is a special drug, the effect of which is still being proven by scientists in relation to some complex diseases.

Many people are mistaken in thinking that a drug can cure any ailment when taken alone. According to research data, as well as from illustrative examples among patients, it has been found that a drug can defeat a disease only in combination with other drugs, most often antibiotics and drugs targeted for a specific disease.

Longidaza is in great demand for gynecological diseases, surgical interventions, and is also often used to treat the upper respiratory tract. Before starting treatment with this medicine, you should visit a doctor, since the wrong dosage can harm your health and aggravate the course of the disease.

Directions for use and dosage

The actual method of using Longidase always depends on a number of parameters: the medical direction, the specific diagnosis, the individual characteristics of each clinical case and the form of drug production.

The dosage, method of application of the drug and the average duration of the course of therapy are determined accordingly.

• in urology: insert one suppository per day rectally at intervals of first one day, then the intervals are increased to 2-3 days. General course – 20 candles;
• in gynecology: one suppository rectally or vaginally per day with an interval of two days. Average course – 10 candles with the possibility of repeating the course;
• in dermatovenerology: one suppository per day rectally with an interval of one to two days. Normal course – 15 candles;
• in surgery: administer one suppository per day rectally with a pause of two to three days. Treatment course – 10 suppositories;
• in pulmonology: one suppository per day into the rectum with a pause of two to four days. The optimal course is from 10 to 20 candles.

For example, one injection per day intramuscularly with a pause of two to three days for a course duration of 5-10 injections (which are not painful to inject). It should be noted that the treatment regimen also involves subcutaneous administration of the solution, performed near the area of ​​skin damage or in the area of ​​scar tissue. This use of Longidase has found its application not only in surgery, but also in orthopedics and cosmetology.

If Longidase is prescribed as a drug that increases the bioavailability of other drugs, the dosage should not exceed 1500 IU in a single injection, and the course cannot be longer than 10 injections for men. It should be added that a second course of treatment with Longidase can be carried out no earlier than 60-90 days after the first course.

Patients unsure of the drug can be reminded that the drug is not a hormonal drug or an antibiotic, and also does not affect sexual activity, unlike other medications.

special instructions

Often suppositories or Longidase injections are prescribed as part of an anti-inflammatory treatment complex. In such situations, it is necessary to take into account possible drug interactions and the enhancement of the expected therapeutic effect of the drugs. This effect is especially observed when Longidase is combined with antibiotics, diuretics, and painkillers due to an increase in their bioavailability for the body.

Salicylates, drugs based on estrogens and glucocorticosteroids may reduce the effectiveness of Longidase.

It is not advisable to combine the drug with alcohol consumption. Longidaza does not affect the speed of mental reaction, so during treatment you can lead a normal life and do all your work.

Composition of the drug, physicochemical properties and price

The drug is produced in two dosage forms: suppositories (method of administration rectally or vaginally) and lyophilisate to obtain a solution for subcutaneous or intramuscular administration.

Reviews: “I gave 10 injections. Since 2007, adhesions have not bothered me"

Hi all! I'm new to the site. My gynecologist prescribed me 10 injections of Longidase plus suppositories with polyoxidonium due to the fact that an ultrasound revealed a small polyp (endometrial, 3 mm). I gave injections, they were a little painful. I came to the next cycle - no polyps were found and no suspicions were found. Longidaza also prevents tissue from growing and relieves inflammation very well, but I think it hardly “cures” adhesions; rather, it acts as an auxiliary remedy, or since adhesions tend to grow and come back, Longidaza prevents this. Although now (a year has passed since then) I again suspect a polyp, albeit of a larger size. They will probably offer to inject Longidaza again...

Pisolkin, https://www.babyplan.ru/user/12591-pisolkin/

I’m already finishing a course of 10 injections, I gave 1 injection every 5 days, along with the injections, as directed by G., I also took Wobenzym + physical procedures, the result is already visible, rather noticeable, the tension during G.’s examination has disappeared, it smears less after M. - diagnosis of endometriosis. As for the fact that these injections are more painful, this garbage, girls, magnesium sulphide is many times more “pleasant”. The unpleasant sensations included slight redness of the buttock and itching. It’s better to buy injections in packs of 5 so that the body can then evaluate how the drug is perceived.

Lizzie, https://www.babyplan.ru/user/12103-lizzi/

It was a long time ago - 7 years ago. A very good gynecologist advised me - I couldn’t get pregnant for several months, I decided not to delay - when we won’t be able to for a year))))) she found an inflammatory process in me. I took Longidaz injections. 5 items. Once every 5 days. – store them in the refrigerator. They are so sick - these injections)))) after 5 months - she became pregnant and gave birth.

Katyusha, https://deti.mail.ru/id1013864976/

I have had postoperative adhesions in my pelvis since 2002. About once every six months there was an exacerbation, the pain was such that you can’t describe it! Sometimes they even called an ambulance because I couldn’t get out of bed. And this happened for several years. After another hospitalization, my gynecologist prescribed Longidaza to me. I gave 10 injections. Since 2007, adhesions have not bothered me. This is a miracle drug!!!! I recommend to all!

Galina, https://www.woman.ru/health/medley7/article/45866/

Hello I took a course of Longidaza in the spring 10 times every 5 days. Prescribed for the treatment of chronic endometritis. Well, in general, I didn’t have any pronounced inflammation. The M's were just very painful and very profuse. Therefore, the treatment was without antibiotics. Among other things, I was prescribed physical therapy (first magnetic laser, then ultrasound), immunomodulating suppositories and homeopathic injections to build up the endometrium. I've only read good things about Longidaza. Well, if in fact. I can’t say that I see a specific result. M remained just as plentiful, after them it smears for a long time. BT in the first phase is quite high. Before treatment she was even better. That's why…..

denken, https://forum.forumok.ru/lofiversion/index.php?t43263.html

Why is Longidaza prescribed?

The range of indications for the use of the drug is wide. In case of pathology of the musculoskeletal system, it helps in the treatment of:

• arthrosis;
• ankylosing spondylitis;
• joint contractures.

In surgery, the solution is used to prevent adhesions and reduce pain after abdominal operations, laparoscopy, treatment of scars after pyoderma, burns, injuries, hemorrhoids.

It is a universal tool for increasing the bioavailability of antibiotics in surgery, gynecology, urology, and to increase the effectiveness of local anesthetics.

In surgery, Longidase solution is used to prevent adhesions and reduce pain after abdominal operations.

For bronchitis

In pulmonology it is prescribed to treat the consequences of chronic bronchitis. Effective in the form of injections and suppositories for pneumosclerosis, siderosis, some forms of tuberculosis, pleurisy, interstitial pneumonia.

In gynecology and urology

Widely used in women with inflammation of the appendages. It is recommended to start inserting suppositories already 1-2 days after diagnosis. Prescribed after pelvic surgery, induced abortion, removal of polyps, for women with endometriosis, fibroids, chronic endometritis and adnexitis.

In urology, it is used in men for benign prostatic hyperplasia, but is effective only in the initial stage. Helps with chronic prostatitis. In both sexes it is prescribed for the treatment of strictures of the ureters or urethra, the prevention of fibrous scars after surgery on the urinary organs, and Peyronie's disease.

Longidaza helps with chronic prostatitis.

In cosmetology

Dermatologists and cosmetologists use lyophilisate to treat scleroderma, non-infectious onychodystrophy, keloid and dystrophic scars. Hyaluronic acid acts as a filler for beauty injections. They help get rid of fine wrinkles, smooth the skin and improve the shape of the face.

Dosage and side effects

When using the drug, you should be very careful, as side effects from Longidaza suppositories may occur. The picture appears like this:

• Allergies such as skin rashes, itching, swelling;
• Angioedema is possible in isolated cases.

Otherwise, the dosage and regimen of use of the drug for various indications are as follows:

• Gynecology. Use vaginal or rectal suppositories, 1 pc. every 2 days. In total you need to use 10 candles according to this scheme.
• Urology. Initially 1 pc. suppositories at night rectally after defecation or a cleansing enema. It is necessary to deliver 10 suppositories every other day. Then the intervals between using the drug are increased to 2-3 days and another 10 suppositories are placed. The total number of capsules used should be 20 pieces.
• Dermatovenereology. Prescribe 1 suppository at night every 2-3 days. The total number of suppositories used is 10-15 pcs.
• Surgery. By analogy with the course of treatment for dermatovenerological pathologies. Number of capsules used - 10 pcs.
• Pulmonology. This means using 1 candle every 2-4 days. The course of introductions is 20 pieces.

Important: for children aged 12 to 18 years, the drug Longidaza is prescribed only rectally. The dosage and treatment regimen are selected exclusively by the attending physician, depending on the severity of the patient’s condition and the duration of the pathology.

Analogues and prices

Structurally, direct analogues of Longidase in the form of injections or suppositories based on the azoximer of bovhyaluronidase are not presented on the Russian market, which makes the drug unique in its own way and irreplaceable by any generics.

As for medicines belonging to the same pharmacological group, according to RLS, the following drugs are available to patients in Russia today:

• Lidaza;
• Lidaza-M;
• Ronidaza;
• Vitaprost;
• Polyoxidonium;
• Dimephosphone;
• Dystreptase.

The cost of these medications, which can be purchased at a pharmacy only with a prescription, is presented in the following table:

Drug price

The price of Longidase in the form of a lyophilisate for the preparation of an injection solution of 3000 IU in bottles is from 1261 to 1782 rubles. per package (5 bottles).

The price of Longidase in the form of suppositories for vaginal or rectal use (3000 IU, 10 pcs.) – from 1120 to 1526 rubles. per package.

Longidaza is a modern enzyme-based drug that has a proteolytic effect.

The product improves immunity and allows the body to resist various microorganisms. As practice shows, medicine alone cannot cure any disease, but in the complex treatment of Longidaza, suppositories, instructions for use for which are included in the package, give a very good therapeutic effect.

Compound

The drug contains one active substance - longidase 3000 IU (1 suppository). The drug contains cocoa butter as additional ingredients. This component is necessary to ensure that the mass of each suppository is 1.3 g.

Release form

Longidaza is available in the form of torpedo-shaped suppositories (3000 IU), which are administered vaginally and rectally, white in color with a faint characteristic odor of cocoa butter. The candles are placed in separate cells, each blister contains 5 pieces. The drug is packaged in a cardboard box with attached instructions.

pharmachologic effect

The drug Longidaza improves the penetration of nutrients under the skin, nourishes tissues, relieves inflammation, reduces swelling, under the influence of the active component, scars and hematomas disappear faster, diseased joints return to normal, become mobile due to the fact that the elasticity of damaged skin that arose before increases. or after surgery, adhesions disappear after a short period of time.

Medicine helps faster and more effectively when the disease is at an early stage. During treatment with Longidaza, the therapeutic effect lasts much longer, all this occurs due to the fact that the active components of the drug are closely related to each other, in addition, the drug has high activity.

In addition to the fact that the drug relieves inflammation due to its proteolytic effect, Longidaza helps improve immunity and has an antioxidant effect.

The medicine completely neutralizes toxins, as a result of which they do not pose a strong threat when they enter the body; in addition, the active substance binds heavy metal ions. Longidaza acts in such a way that there are no connective tissue scars on the patient’s body. Before using Longidaza suppositories, the instructions for use must be studied by each patient, the doctor warns about this.

Clinical studies have proven that Longidaza does not have a toxic effect on the human body and does not have mutagenic or carcinogenic properties. In addition, the drug does not reduce or disrupt the functioning of the reproductive and immune systems. In most cases, the drug is well tolerated by patients.

Pharmacodynamics and pharmacokinetics

After rectal or vaginal administration, the drug is quickly absorbed into the tissues and distributed throughout the blood; its highest concentration was noticed already 1.5 hours after administration. The medicine does not accumulate in the body and is excreted by the kidneys after three days.

Features of application

The release form (powder for injection) involves introducing the solution under the skin (in the vicinity of the lesion or scars) or intramuscularly.

The standard ones are:

• dosage for 1 injection – 3000 IU.
• course – 5–25 injections;
• the time interval between injections is 3–10 days.

Longidase injections are made intramuscularly or subcutaneously near scars or a lesion.
For changes in connective tissue of a chronic nature, it is advisable to supplement the basic course with a maintenance course, in which 3000 IU is administered at intervals of 10–14 days.

There are a number of nuances of use for different diseases:

• injection under the skin is appropriate for joint diseases, hematomas and skin lesions. For scars, it is possible to administer intra-scar and/or alternate injections - subcutaneous with intramuscular;
• a minimum course (5 injections) is acceptable to prevent adhesions after surgical manipulations in the abdominal or pelvic area;
• if the alveoli of the lungs are affected and tuberculosis requires long-term maintenance treatment (up to 12 months).

If it is necessary to enhance the effect of antibiotics or painkillers, ampoules of 1500 IU are more often used. The main drug is administered 10–15 minutes after the Longidase injection in the same place. Both agents should be injected in the same way - under the skin or into muscle tissue.

The preparation algorithm for the drug is as follows:

1. The powder from a 3000 IU bottle or ampoule is diluted with 1–2 ml of procaine (0.25% or 0.5%). If procaine is poorly tolerated by the patient, use 0.9% sodium chloride for injection or water for injection. When it is necessary to enhance the effect of other medications, 3000 IU is diluted with 2 ml of 0.9% sodium chloride, and 1500 IU - 1 ml.
2. The solvent is gradually added to the ampoule (bottle).
3. After 2–3 minutes, the solution is carefully mixed, avoiding shaking and foam formation.

Features of using the drug for different age groups:

• Aged people. The drug's good tolerability allows it to be prescribed to patients in old age. In this case, it is necessary to monitor indicators of the general condition of the body in order to avoid the development of negative reactions from organs and systems.
• During pregnancy and lactation. Administration of the drug in the form of injections is prohibited during pregnancy and breastfeeding.
• In childhood. It is prohibited to use injections to treat persons under the age of 18 due to the lack of clinical data.

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Suppositories for adenoma and prostatitis

Longidaza suppositories for prostatitis are used according to the following scheme:

• 20 candles are used.
• The first 10 suppositories are inserted into the rectum at intervals of 2 days.
• The next 10 procedures are performed once within 3 days.

Patients need to know that sometimes pain may appear in the anal area, which disappears after completing the full course of therapy.

Contraindications and possible adverse reactions

Longidaza suppositories in the treatment of prostatitis are usually well tolerated by patients, but in rare cases the following may occur:

1. The appearance of dyspeptic symptoms, the development of which is accompanied by a violation of the act of defecation (diarrhea), the occurrence of nausea, sometimes with vomiting.
2. In the area where the drug is administered, allergic rashes may be observed, accompanied by a feeling of itching and swelling (like urticaria).
3. The injections are characteristically painful, and after they are administered, the sensation of pain may persist for several days.

Situations when medicine is not prescribed:

1. When the patient is under 18 years of age, it is prohibited to use injectable forms. Suppositories are prohibited until the age of 12.
2. Initial development of the disease in acute form.
3. Manifestation of signs of hemophthalmos (when hemorrhage occurs in the vitreous body).
4. Any type of malignant tumor.
5. Impaired kidney function.
6. If the main or additional ingredient is an allergen for the patient.

Composition and release form

Pharmacies offer different forms of medicine.

Each suppository contains bovhyaluronidase azoximer at a dosage of 3000 IU.

Suppositories that can be used rectally and vaginally. Each suppository contains bovhyaluronidase azoximer at a dosage of 3000 IU. The excipient that provides the form to the drug is cocoa butter. One package can contain 10 or 20 pieces.

A lyophilisate is available in vials or ampoules to dilute the solution, which is administered intramuscularly or subcutaneously. One ampoule may contain 1500 or 3000 IU of active ingredient.

Longidaza

Release form - lyophilized powder to prepare a solution for intramuscular, subcutaneous and intravenous injections of 1500 IU and 3000 IU, suppositories for rectal or vaginal use 3000 IU.

The active ingredients are hyaluronidase and azoximer bromide.

The drug Longidaza is prescribed for the treatment of certain urological (prostatitis, cystitis), dermato-venereal (scleroderma, prevention of fibrous infections), surgical (postoperative adhesions, burns, keloid scars), pulmonological (tuberculosis, pneumonia) and gynecological (endometritis, infertility), orthopedic (arthrosis, joint contracture) diseases. It reduces acute inflammation in the body, is quickly absorbed and distributed throughout the body (within 30 minutes) and is excreted in the urine.

Method of administration - for intramuscular, intravenous or intradermal administration, it is necessary to add 2 milliliters of 0.5% or 0.25% procaine solution, 0.9% sodium chloride solution or special water for injection to the contents of the drug ampoule. The solution is applied once immediately after preparation. Suppositories are administered rectally or vaginally once throughout the day before going to bed. When administered rectally, it is necessary to cleanse the intestines in advance; when administered vaginally, the suppository must be administered in a lying position.

The necessary course of treatment is prescribed by the doctor who is treating, on average it varies within 10-20 doses of the drug (the duration of the course depends on the severity of the disease and the age of the patient).

Side effects - upon injection: pain, skin hyperemia and swelling at the injection site, allergic reaction.

Contraindications – for malignant neoplasms and tumors, allergies to parts of the drug, during pregnancy and lactation, children under 12 years of age.

Indications for use

The versatility of the drug’s effect on the human body has made it possible to expand its use to a number of important areas of medicine, independent of each other. The relevance of using Longidase is always determined by the doctor in each specific case. But all experts note that the medicine is accepted without problems by a wide variety of categories of patients, and does not pose any threat at all when used in moderate doses.

• gynecology: prevention and treatment of adhesions in the genitourinary system in case of identified chronic inflammation - in particular, after surgery, due to intrauterine synechiae, inability to get pregnant and endomyometritis;
• urology: congestive prostatitis, cystitis, Peyronie's disease, mild form of prostate adenoma. Additionally – urinary tract strictures, prevention of the appearance of scar tissue after surgery on the urethra, ducts or bladder;
• in surgery: combating adhesions after abdominal surgery on organs, as well as eliminating persistent wounds;
• in pulmonology: treatment of the consequences of fibrosis caused by pneumonia, tuberculosis, siderosis, pleurisy or alveolitis.

Taking into account its composition, in a number of situations Longidaza is actively used for the treatment of limited type scleroderma and the subsequent prevention of fibrotic phenomena caused by infections such as STDs. In all of the listed areas of medicine, the drug should be used as an effective measure to improve the penetration of antibacterial drugs to diseased tissues and body systems.

Reviews from men

On independent resources there are comments from men who were treated with suppositories and injections of Longidaz for prostatitis. Reviews are mostly positive; patients report that the therapy helped them cope with the disease and survive the period of exacerbation.

Andrey, 42 years old:

“Acute prostatitis arose as a complication after a respiratory infection. I suffered so much from pain that I had to take time off from work at my own expense. I hoped to get by on my own, but when blood appeared in my urine, I rushed to the urologist. He prescribed Longidaza and Prostodin. The first one made my muscles hurt a little, but this is minor compared to the result. All symptoms went away, and sex life returned to normal.”

Victor, 54 years old:

“I like Longidaza because it is sold in suppositories and injections. I don’t like pills - they also plant the liver, which is not in the best condition in old age. In general, thanks to the suppositories, the inflammation went away and the swelling disappeared. Now I’ve forgotten about the exacerbations and, I hope, I won’t have to remember. The doctor says that the disease did not have time to become chronic.”

Valery, 47 years old:

“I have already been living with calculous prostatitis for 5 years. I tried many treatment regimens, but the disease continued to “delight” me. About a year ago, a urologist prescribed Longidaza by injection with parallel use of Prostodin. I received injections in courses, and it became easier, I took the drops according to the instructions. In addition, he began to actively engage in sports and do special exercises. In the end, I was completely cured."

Mikhail, 38 years old:

“I’m not even forty, but I’ve been diagnosed with chronic prostatitis for a year and a half now. It seemed that life ended there. I constantly want to go to the toilet, it’s hellish torment. I forgot to even think about sex with my wife. I recently changed my doctor, and he advised me to take a course of Longidase with antibiotics. The first one was ordered to be taken in 2 courses, but after the first I felt significant relief.”

Side effects, contraindications and harm

Despite the fact that the drug helps in the vast majority of cases, it also has contraindications. These include the following:

oncological diseases; personal intolerance to any of the components; acute renal failure; bleeding from the lungs (in some cases, taking the drug is allowed, but with caution).

Adverse reactions are uncommon. The most common discomfort is felt at the injection site: swelling, itching. Moreover, they may not appear immediately, but after a few days. If negative reactions occur, discontinuation of the drug may be necessary.

In general, the medication is quite safe, but in order to prevent negative consequences, you should consult a doctor before using it.

Who shouldn't

Despite the relative safety of Longidase and good tolerability, there are contraindications to the drug. These include the following:

• hypersensitivity to the components of the drug;
• bleeding from the lungs;
• vitreous hemorrhage;
• diagnosed oncological diseases;
• renal failure;
• not recommended during pregnancy and lactation.

Complications of taking

Reviews from doctors and women who have used the drug indicate the following possible side effects:

• pain - at the injection site when using injections;
• itching, redness, slight swelling - at the injection site or in the vulva and vaginal area.

Usually, all discomfort associated with the use of the medicine goes away on its own within three days and does not require additional treatment. If doses and dosage regimens are not followed, an overdose may occur. The condition is characterized by fever, headache and dizziness, and a drop in blood pressure. In this case, you must seek medical help.

Composition and release forms

The drug is available in two forms:

• Suppositories for rectal use. They are used most often for non-advanced stages of the disease. Suppositories are very convenient because the patient can use them independently.
• Solution for intramuscular administration. It looks like a white mixture with a yellowish tint. One package contains five bottles. It must be taken into account that injections should not be administered into the affected areas.

The active components of the composition are azoximer bromide + hyaluronidase. They help increase cell capacity, speed up metabolic processes, increase the elasticity of connective tissues and blood circulation, and cleanse blood vessels. All this helps accelerate the delivery of oxygen and nutrients to the affected cells.

The medicine in the form of a solution gives the fastest effect

The drug in the form of rectal suppositories is more convenient to use

Analogues of the drug

If the patient feels the need to replace the prescribed drug with an analogue, then the following medicines can be purchased in Russian pharmacies:

• Lidaza. It has a good softening anti-scar effect, increases joint mobility, actively resolves fibrous formations and hematomas, and relieves swelling. Especially if the prostate in men is inflamed.
• Ronidaza. The drug is in the form of an ointment, which also has an active effect on cicatricial joints, hematomas, etc.

It is important to understand that any adjustment to the prescribed treatment must be carried out with the consent of the attending physician. Otherwise, unexpected reactions from the body may occur.

Source manexpert.ru

Instructions for use

According to the instructions for using injections, Longidaza is administered subcutaneously and intradermally, intramuscularly or under the scar. The dosage and duration of treatment are determined by the attending physician and depend on the age and severity of the patient’s disease. After two to three months, the course can be re-prescribed.

Chronic diseases that occur with rapid formation of connective tissue require, after conventional therapy, long-term administration of Longidase in the form of injections, with breaks of 1-2 weeks. To make the effect of painkillers more effective, Longidase should be administered to the same place 15 minutes before the anesthetic at a dose of 1500 IU.

During therapy, a bottle of 3000 IU is diluted in 1 or 2 ml of saline, water or procaine.

The bottles are also used for inhalation (diluted with water) and electrophoresis (diluted with sodium chloride).

The prepared solution cannot be stored. Intravenous administration is prohibited.

Treatment with suppositories lasts from 10 to 20 days, with a dosage of 1 piece per day.

Treatment regimens

The course for adhesions in the pelvis lasts from 3 to 5 days. Injections of 3000 IU are given intramuscularly three times daily. Infertility therapy includes 15 injections of 3000 IU. The first five are done once every three days, the rest - once every five days. According to the instructions for the use of Longidaza suppositories in gynecology, the course consists of 10 suppositories (1 piece every 2 days).

The course of chronic prostatitis is from 10 to 15 intramuscular injections of 3000 IU, which are given every five days. Treatment of cystitis is carried out with the same dosage, but in a course of up to 10 injections. Suppository therapy includes 20 suppositories (one suppository every 2 days).

For adhesive disease, injections of 3000 IU are given every three to five days, a total of 15 injections are needed. Treatment of wounds - injections of 1500 IU once every five days (5-10 injections).

For scleroderma, injections of 3000-4500 IU are prescribed intramuscularly once every 3-5 days. In total you need to complete a course of 20 injections.

The course of treatment for scars is 15 injections of 3000-4500 IU once every three days; suppositories - one piece every two days (total 10-15 suppositories per course).

Pneumosclerosis - a course of 10 injections of 3000 IU once every 5 days.

Tuberculosis - intramuscular injections of 3000 IU once every five days (25 pieces in total) or treatment with suppositories (10-20 pieces), in which 1 suppository is administered every three days.

Treatment of joint contracture and arthrosis is carried out with subcutaneous injections of 3000 IU once every three days in a course of 10-15 injections. For hematoma, the dosage is similar, only 5 injections.

When to use

Longidaza suppositories are prescribed for all diseases where there is hyperplasia (pathological growth) of connective tissue. The range of applications covers a list of ailments.

• Urology. For narrowing of the ureter and urethra, for acute and chronic cystitis, for prostate hyperplasia, for the prevention of scar formation after surgical operations on the organs of the urinary system.
• Dermatovenerology. For connective tissue diseases (for example, scleroderma), to prevent the formation of scars and narrowing during active inflammation.
• Surgery. In order to prevent active adhesions on the abdominal organs after operations, as well as to improve the healing of complex wounds.
• Pulmonology. Used for tuberculosis, pneumosclerosis and other processes in which lung tissue is replaced by connective tissue.
• Orthopedics. During the treatment of joint contractures, spondyloarthrosis.

The use of Longidaza suppositories in gynecology also has a wide range of diseases. The drug is used:

• in complex treatment for follicular ovarian cyst;
• with tubal factor infertility;
• with adhesions inside the uterine cavity;
• for chronic and acute adnexitis;
• for any form of endometritis, cervicitis;
• after operations and laparoscopy;
• after minor manipulations (curettage, abortion);
• with endometriosis.

Longidase suppositories for endometriosis, adhesive disease, ovarian cysts and infertility, as well as for the prevention of other complications due to connective tissue hyperplasia are the means of choice.

"Longidaza" allows you to preserve the anatomical location of all internal organs, avoid the formation of adhesions, maintain reproductive health and increase the chances of pregnancy. In addition, the drug is used in anesthesiological practice to enhance the effect of certain substances.

Indications and contraindications

Doctors of various specialties use Longidaza in their practice. Indications for use of the drug in the form of injections may be as follows:

• adhesions;
• contractures and inflammation of joints;
• non-healing wounds and scars after surgery and skin damage;
• subcutaneous hemorrhages;
• cicatricial changes after burns;
• cystitis;
• pneumofibrosis.
• scleroderma;
• tubal infertility, accompanied by adhesions in the pelvis.

The drug should not be used in the treatment of children under 12 years of age. Injections are not prescribed to pregnant women, patients with malignant tumors and individual intolerance to hyaluronidase.

In case of severe renal pathologies and pulmonary hemorrhages, the drug is used with caution.

"Longidaza" in gynecology is used more often in the form of vaginal suppositories. Suppositories are used in the treatment of the following diseases:

• chronic endomyometritis;
• adhesions in the pelvis after inflammation, abortion or surgery;
• tubal infertility.

In addition, rectal suppositories have found application in the treatment of urological diseases:

• prostatitis;
• Peyronie's disease;
• cystitis;
• fibrous changes in the ureters and urethra;
• hyperplastic changes in the prostate gland;
• to prevent adhesions after urological operations.

Contraindications for prescribing suppositories are the same as for Longidaza injections. Instructions for use recommend the use of injections and suppositories for better absorption of other medications.

The effectiveness of treatment with Longidaza

In most cases, according to practical medical research and reviews from forum members, the use of Longidaza suppositories and injections has a beneficial effect on restoring lost fertility. Thus, for many women, after using the drug as part of a complex treatment, tubal patency improved, the severity of adhesions in the pelvis decreased, nagging pain in the lower abdomen, spotting and pain during menstruation disappeared, menstrual blood loss decreased, and the structure of the endometrium was normalized according to ultrasound results , laboratory blood test parameters improved and, finally, the long-awaited pregnancy arrived.

What is unique about this medicine?

The manufacturer declares the innovative advantages of this medication:

• Longidaza is the most prescribed drug in Russia against adhesions and fibrosis.
• The originality of the derived molecule was recognized by the World Health Organization.
• The described pharmaceutical agent helps to increase the effectiveness of complex treatment of diseases.
• The drug also boasts proven effectiveness and a favorable safety profile.
• The medicine has a complex, prolonged effect.
• It is possible to use the drug for any form of pathology (acute or chronic).

Thus, Longidase is an enzyme preparation with a proteolytic effect, that is, it promotes protein breakdown. Thanks to its use in the body, permeability improves along with tissue nutrition. With the use of this remedy, people's hematomas resolve, and swelling becomes less. Joints gain mobility due to increased elasticity of the damaged skin, and adhesions with contractures completely disappear.

Moreover, this medicine is considered especially effective at the initial stage of pathological processes. "Longidaza" injections are endowed with activity and a long-lasting therapeutic effect. In addition to a pronounced proteolytic effect, it has anti-inflammatory, immunomodulatory and antioxidant properties.

Pharmacological properties of the drug

So what is this medicine and how exactly does Longidaza work? According to the classifier of pharmacotherapeutic groups, which subdivides all medicinal products in accordance with their pharmacological action and field of medical use, Longidaza is an enzymatic agent. This suggests that the active principle of the drug is enzymes that act as catalysts for the breakdown of proteins.

Longidase has a complex structure and is characterized by high proteolytic (hyaluronidase) activity and a prolonged therapeutic effect. The composition is a combination of 2 unique chemical substances that have an independent therapeutic effect on the body. In the preparation, these active substances with different properties are connected to each other using a conjugation reaction (direct contact between cells is ensured). The result is an artificially synthesized hybrid molecule called bovhyaluronidase azoximer.

In 2019, this compound was recognized by the World Health Organization. After being assigned a unique name (INN), recognized throughout the world, the drug Longidaza was added to the List of Medicines Recommended by WHO.

The patented formula provides the following pharmacological properties:

• antifibrotic effect - a solution to the problem of pathological growth of connective tissue due to the effect of the active substance on all phases and links of the development of fibrosis. Blockade of the synthesis of connective tissue components (mainly collagen) due to the binding of released iron ions, dissolution of the final formed focus of fibrotic changes;
• anti-inflammatory effect – regulation of the production of inflammatory mediators, suppression of the inflammatory response, reducing the risk of chronicity of the process;
• anti-edematous effect - reducing the permeability of the vascular wall, eliminating edema;
• immunomodulatory activity - improving the functioning and restoration of the functions of the immune system;
• antioxidant and detoxifying effect - neutralizing free radicals, ridding the body of toxins, slowing down oxidation processes in cells and their premature aging.

Instructions for use of the drug

The drug is available in the form of suppositories for rectal or vaginal use and a solution for intramuscular administration.

If Longidaza injection is prescribed, the instructions for use are required to be studied. The dosage and method of administration are determined by the doctor individually, depending on the patient’s age, the complexity of the pathology and the stage of the disease. The drug is administered intramuscularly or subcutaneously in close proximity to the affected area at a dose of 3,000 international units.

The medicine should not be injected into the site of infection, inflammation or tumor. The course of treatment may require 5 to 15 injections with a pause between injections of 3 to 10 days. If necessary, treatment can be repeated after a few months. When prescribing Longidaz 3000 injections, the instructions for use indicate the preparation of a solution for injection under the skin or into a muscle. To do this, the contents of the ampoule are dissolved in 2 ml of a 0.5% novocaine solution. If you are intolerant to the anesthetic, the medicine can be dissolved in water for injection or in a solution of 0.9% sodium chloride.

The second form of the drug - suppositories - are inserted deep into the anus (after defecation) or intravaginally at night. The course can be 10-20 days with breaks of several days.

If you are interested in the question of how much Longidaza costs, then it all depends on the pharmacy where the medicine will be purchased. The average cost of the drug for injection is 1,950 rubles, and for suppositories - 1,850 rubles. The package contains 10 ampoules or suppositories, which are enough for 1 course of treatment if the disease is mild.

At the pharmacy, Longidaz injections are dispensed as prescribed; suppositories can be purchased without a prescription from your doctor.

The medicine must be stored in a dry place, away from direct sunlight. Optimum temperature for storage is +2…+15°C. The drug can be used for 24 months from the date of manufacture.

https://youtube.com/watch?v=gB1nQP1-s_E

LONGIDAZA: The woman’s health is under control!

Tell me, has anyone been treated with this drug for not just adhesions, but hydrosalpinx? I was given such a disgusting diagnosis that I was simply in shock. I read about “double-sided hydros” on the internet and it turned out that getting pregnant is impossible. maybe these candles will help me. or injections? What is better for treating pipes - suppositories or injections?

I also have hydrosalpinx on the left. I tried Longidaza suppositories in one course. There was very strong watery discharge, most likely due to hydrosalpinx. Perhaps the treatment process has begun, which is why there is an exacerbation. I want to try again, I have nothing to lose. I also want to go for a consultation on gynecological massage. What if it helps?

I have had adhesive disease for 15 years. I had an emergency operation at the age of 17 for a cyst on the right ovary. They cut my entire belly. - I gave birth to my first child at the age of 21. We are planning a second one this summer. I’m 33 years old. The doctor says that there are a lot of adhesions, but he didn’t say where (on the stomach along the seam or in the pipes). I'm going to go for an ultrasound and find out in detail.

I learned about Longidase yesterday from a friend. Has anyone tried to treat adhesions after surgery to remove a cyst that are very stubborn? How dangerous are adhesions during pregnancy? And what do they threaten? I had several abortions (the last one was 2 years ago), i.e. pregnancy occurs without problems (but there were not “on time, so to speak”). The doctors did not offer Longidaza, only vitamins and immunomodulators.

Varenka, my friend, doctor b.n. works in a reproduction clinic, almost everyone gives birth to them, my friends have acquired double happiness: a boy and a girl. This is in Khapkovo, if necessary, I’ll tell you :0

I have been undergoing treatment for infertility for 4 years, 1 tube is blocked, I took Diana 35, so after the withdrawal we tried it and prescribed Longidaza suppositories, but they didn’t say how much to take, like on any day, but I don’t understand how to take it every day or what?

My friend told me about this drug literally today! She took only 3 injections, and a miracle happened! We are also planning to give birth to a baby, but time passes, and our hands are sinking lower and lower. I want to try! Maybe everything will work out, with God’s help! On the advice of doctors, I have already spent thousands on medications, but it’s all to no avail! Good luck to everyone! and happiness to be a MOTHER.

Hello everyone, I inject Longidaza, I took 5 injections, I’m going to buy 5 more ampoules, but my doctor said that it’s useless, but I don’t believe it, I hope it will help.

We suggest you familiarize yourself with: Succinic acid to improve potency

Good afternoon, please tell me, maybe someone knows for sure, with adhesions in the pelvis, what is the best way to place suppositories rectally or vaginally?

I bought suppositories and put them rectally, I’m planning a pregnancy, I hope they will help.

Girls, suppositories are super, 2 pieces left, then I will do an ultrasound, the pain is completely gone, I feel good, I think that the adhesions in the pelvis are no longer the same as they were, I decided that if the ultrasound says that there are fewer adhesions, then I will still inject 10 injections of Longidaza 1 every 5 days for more effect. At least after the candles I’m happy as an elephant!

Comparison with analogues, table of names and prices

The drug has a number of analogues:

The drug is in the form of a solution that can be used externally or for injections

As you can see, the drug Longidaza is significantly more expensive than its analogues, which is its main disadvantage and pushes patients to look for cheaper taxes.

The high effectiveness and safety of the drug justify its price

For prostatitis and other male diseases, it is important not to self-medicate, but to consult a specialist

Known analogues (briefly)

Cheaper analogues of Longidase can be purchased in pharmacies. They have different compositions, but approximately the same operating principle. The drug has no structural substitutes for its main component. The most famous generics:

1. Ronidaza. Available in the form of lyophilisate and powder for external use. The enzymatic medicine is obtained from the testes of bulls. Responsible for the breakdown of hyaluronic acid, increasing the permeability of blood vessels. Approximate cost: from 190 rubles.
2. Cystamine. Available in tablet form. The active ingredient is a substance of the same name, the concentration of which may vary. It has a radioprotective effect and is responsible for tissue repair. Price - from 300 rub.
3. Neovasculgen. The lyophilisate contains plasmid deoxyribonucleic acid. The basis of a gene therapy drug is the human gene. Stimulates normal blood circulation, tissue repair and strengthens the walls of blood vessels. Cost - from 650 rubles.
4. Kokkulin. The herbal preparation has antioxidant and immunostimulating effects. Can be taken with kinetosis. The homeopathic remedy is sold in tablet form.

The above medications do not have an effect completely identical to Longidase. They are prescribed only after a complete examination and identification of possible contraindications in the patient to the original medication. The cost of analogues may vary depending on the manufacturer.

What does 3000 ME mean?

3000 IU means that one ampoule or suppository contains the appropriate number of international units of the hyaluronidase complex, as well as a high molecular weight carrier. This dosage is used for the treatment and prevention of pathologies leading to the development of fibrosis, the formation of adhesions and scars.

According to the instructions for “Longidase” injections, this medicine has proven itself as a complex remedy, but is also suitable for monotherapy of various pathologies. It serves as the drug of choice among physicians in the presence of adhesions, connective tissue hyperplasia, and so on.

Description of the drug

Longidase is an artificially synthesized chemical compound of hyaluronidase (a proteolytic enzyme) with a high molecular weight carrier that has pronounced immunomodulatory activity.

Instructions for use of Longidaza in the form of suppositories inform about the high enzymatic activity of the substance on the body for a long time. The drug is used for a progressive increase in the number of connective tissue cells, which entails their massive proliferation in different organs.

Compatibility of alcohol and Longidase

The medicine should not be taken together with alcohol. The minimum time that must pass before using the medication is 8 hours after drinking alcohol for men and 14 hours for women. You can drink alcohol the day before injections or use suppositories.

According to doctors, it is generally better to refrain from drinking “alcoholic beverages” during therapy. During illness, the body's immunity is reduced, and resistance to the disease is reduced. Additional stress on the liver and internal organs when processing ethanol is unacceptable.

It makes no difference which dosage form of Longidase is used for treatment: injections or suppositories, the active ingredients affect the body in the same way.

In the liver, as well as in the bloodstream, when confronted with products of the processing of wine alcohol, the effect of Longidase is reduced. Therefore, it is not recommended to combine the drug with alcoholic beverages.

The main rules for taking products that contain ethanol and drugs without harm to health are:

1. Take the medicine two days before drinking.
2. Do not exceed the safe concentration of alcoholic beverages, regardless of the type - wine, beer or something strong.
3. Drink enough water during a hangover.
4. Continue drug therapy after alcohol is removed from the body (2 days).

The main mistake people make is failure to comply with the last point. On the day when you need to continue using the medicine, you must completely abstain from alcoholic beverages. Whether or not to drink alcohol during treatment with Longidase is up to the individual to decide.

Doctors require that ethyl alcohol be avoided during therapy. After the end of Longidase therapy, the recovery course may be prolonged, so the time for resolution of libations is postponed.

But it is best to exclude alcohol from the diet during the entire therapy. If this is not done, the effectiveness of treatment will greatly slow down. Since Longidase contains substances that are intended to regulate the processes of creating tissue matter, in medicine it is used to stop the growth of tissue cells.

Restrictions

According to the instructions for use, it is known that contraindications to Longidase:

1. Hemoptysis (coughing up sputum containing blood from the larynx, bronchi, or lungs).
2. Pulmonary hemorrhage (a complication of various respiratory diseases, which is accompanied by bleeding from the bronchial or pulmonary vessels).
3. Malignant tumors.
4. Acute kidney diseases.
5. Pregnancy period.
6. For solution - up to 18 years, for candles - up to 12 years.
7. Fresh hemophthalmos (hemorrhage into the vitreous body of the eyeball and surrounding structures caused by damage to the vessels of the retina and subretinal space).
8. Breast-feeding.
9. Acute infectious diseases.
10. Increased individual sensitivity to drugs based on hyaluronidase.

Longidase is recommended with extreme caution for chronic kidney diseases.

How does the drug work?

Obstruction of the fallopian tubes (adhesions) is formed from connective tissues. They contain a high content of hyaluronic acid, which must be acted upon in order to break it down. The main component of the drug is hyaluronidase. This substance causes the breakdown of acid, making it less viscous. As a result, the connective tissues become less elastic, the fallopian tubes, ovaries and neighboring organs begin to cleanse, their patency improves, as a result of which a woman’s chances of becoming pregnant are greatly increased.

Lidaza is most widely known in gynecology in the treatment of diseases such as adhesions, which occur after undergoing any operations on the female pelvic organs or other diseases of the female genital organs (for example, salpingitis, andexitis). With this remedy you can treat infertility caused by adhesions.

The drug Lidaza is available in several forms:

1. In the form of a solution, which is used when giving injections or making injections.
2. In the form of a solution, which is used if external use is necessary.
3. In powder form for external use.

A less common form, which is also the medicine Lidaza, suppositories. Such a suppository in the form of suppositories is usually not produced for the mass consumer; it is not commercially available. It can only be obtained with a prescription from a medical specialist, which the person provides to the pharmacist at the pharmacy.

Pharmaceutical properties

Lidase is an enzyme drug that is isolated from the testes of cattle. This medicine is able to break down a special substance in connective tissues, hyaluronic acid. It reduces tissue swelling, softening the patency of the fallopian tubes. Continues to operate for two days.

Electrophoresis with Lidase in gynecology is an effective physiotherapy procedure. It allows the substance to be delivered to the organ whose surface is damaged. Due to the gentle effects of electric current and medication, the latter reaches the affected area and does not pass through the digestive system and blood.

According to many studies and reviews, Lidaza is most effective in the first few weeks after:

• conducting operations;
• occurrence of injury;
• manifestations of the disease.

Indications for use

The drug in question is used in medicine to treat many different diseases, including to eliminate painful symptoms. According to the instructions, it is prescribed in the following cases:

1. Poor joint mobility.
2. When scars of various types occur (for example, after surgery, injury or burn).
3. If any skin diseases develop.
4. For osteoarthritis.
5. If a prolonged ulcer occurs.
6. For various inflammations and injuries.
7. In case of damage to the lumbar region or spine.
8. When myocardial infarction occurs.
9. In case of inflammation of the respiratory tract.
10. In case of hematomas on the surface.

The medicine is prescribed to women who have acute and chronic inflammatory processes. Initially, the patient should use antibiotics, and then the drug Lidaza with a resolving effect along with physiotherapy.

If a woman closely monitors her health and wants to get pregnant and carry a child without problems, then the course of treatment should be completed, and the medicine should be used regularly along with other prescribed treatment.

Electrophoresis with Lidase

Typically, this medicine is used in the form of suppositories or powder; it dissolves, after which a solution is obtained, which is used for injection. Electrophoresis with this drug has the highest efficiency.

This process is based on the effect of an electric current that is passed through the drug. Then the active substance, which underlies the composition of the drug, enters the connective tissue in a small amount.

To completely get rid of the occurrence of adhesions or other gynecological diseases, ten applications are enough. There are also more severe cases, then the specialist doctor extends the course of treatment, or carries it out again.

Contraindications for use

Before using Lidaza, you should carefully study the instructions. According to it, this medicine has the following contraindications:

1. The presence of an inflammatory or infectious disease (acute).
2. Individual intolerance to the components included in the drug.
3. The presence of hemorrhage, loss of a large amount of blood.
4. Malignant or benign tumor.
5. Tuberculosis (in any form).

For any of the above reasons, the use of the drug is completely contraindicated in order to avoid serious consequences. In addition, the medicine should not be used by persons under 18 years of age.

Use of the drug

As is already known, medicine in the form of suppositories is not produced in large quantities; they are usually ordered by prescription from a medical specialist in pharmacies. He will advise you in detail about the procedure for taking the medicine. Instructions for use of the gynecological drug Lidaza are as follows:

1. The drug in the form of suppositories is administered inside the vagina, one suppository per day.
2. Then two days later, that is, on the third, the procedure is repeated.
3. To completely cure the disease, improve the passage of the fallopian tubes and break down the viscosity of connective tissues, the treatment course with suppositories is approximately 10 injections into the vagina.
4. Each session must be done on time and regularly; long breaks should not be allowed, because this medicine has a cumulative effect and has the best effect on the body when used regularly.

Side effects

The gynecological drug Lidaza can cause side effects. Often, consumers indicate in their reviews that the human body tolerates this drug quite well, even with severe illnesses or if the patient is highly sensitive. Despite this, sometimes the drug can cause an allergic reaction, manifested as a lesion on human skin.

The instructions for the drug indicate the dosage in which it should be used. In cases of overdose, the following characteristic symptoms appear:

1. Chills, body temperature rises.
2. Nausea and vomiting.
3. Severe dizziness.
4. Blood pressure rises or falls.
5. The area where the medicine is applied swells.
6. A skin rash may form as a result of an allergic reaction.
7. Sometimes urticaria can be observed.

If at least one of these symptoms appears, you should immediately administer intravenous epinephrine, and then immediately consult a specialist doctor.

Interaction with other drugs and storage

Lidaza increases the effectiveness of other local anesthetics; it is often specifically used to improve the absorption of other drugs. But medical specialists recommend combining it with other medications with extreme caution, because there is a huge chance that absorption will increase. In addition, systemic effect may be significantly increased.

Lidaza is not available in large quantities. This drug is prescribed only with a prescription from the attending physician, which the person must provide at the pharmacy. Only after this the medicine is given to the patient.

The medicine should not be stored in a room with elevated temperatures or high humidity. The optimal temperature for storing the drug is up to 27 degrees Celsius.

The shelf life of the medicinal product is indicated in the instructions for use; it is two years from the date of its release. Provided that the medicine is stored in packaging and at the required temperature, the medicine will not lose its healing properties until the expiration date. If the expiration date has expired, it is not recommended to use the drug to avoid side effects and serious consequences.

Adhesions can be effectively eliminated if the medicine is used immediately after the injury. But medical practitioners note that women are actively involved in the treatment process as long as they experience pain or discomfort. As soon as they pass, patients stop the prescribed course of therapy. This approach is futile, since the removal of these symptoms does not mean that the problem of adhesion formation itself has been eliminated. The result of such carelessness is the emergence of problems with conceiving a child. Therefore, the main recommendation that must be followed is the complete course of treatment prescribed by the doctor.

Patient reviews

As for joint use with other drugs, Lidaza tends to enhance the effect of local anesthetics and is often used to improve the absorption of other drugs.

Doctors prescribe the drug with extreme caution simultaneously with certain other drugs, since there is a risk of increased absorption, and there is also the possibility of systemic action.

Lidase cannot be stored in conditions of high humidity and high temperature; the permissible storage mode is up to 25 degrees. The shelf life is 2 years from the date of production in an airtight container. It is not recommended to store the product after the expiration date.

Lidaz candles are not very expensive, the average cost is 160-250 rubles.

Lidaza is available in powder form and is intended for injection, external and local use. In pharmacies it is sold in the form of ampoules or bottles, as well as in the form of suppositories. 1 ampoule contains 64 units of hyaluronidase. The instructions for use provide detailed information on how to use this or that product. The doctor writes out the prescription in Latin, and Lydaza for injection is written as follows: Lydasum (pro injectionibus).

The drug "Lidaza" is produced in the form of a lyophilisate and is a white powder from which injections are made or used for external use. The powder is

. The powder contains the main active ingredient - hyaluronidase, its share is 64 CU for each ampoule of additional substances.

The drug is packaged in cardboard boxes containing 10 ampoules. Also included is a solvent for “Lidaza” - a solution of procaine - 5 mg or sodium chloride - 2 mg. Along with the drug and solvent, a special ampoule knife and instructions are included.

The use of Lidaz is possible in the following cases:

• an injection of the drug helps get rid of pathologies such as keratitis;
• the drug is effective in the complex treatment of rheumatoid arthritis;
• helps in the treatment of long-term non-healing ulcers, in particular radiation ones;
• the injection will also be effective in the treatment of diseases such as myocardial infarction, lumbar disc pathologies and hydrocephalus;
• "Lidaza" is used to treat contractures and inflammation of the bronchi, tuberculosis and lesions of the upper respiratory tract;
• the drug also gives a good effect in the treatment of osteoporosis, tenosynovitis, fibromatosis;
• the use of the medicine is possible to eliminate hematomas;
• with the help of "Lidaz" you can get rid of such ailments as arachnoiditis, hyphema, hemophthalmos, retinopathy;
• in addition, the drug is actively used to prepare the patient for plastic surgery associated with scar tissue;
• "Lidase" is actively used as an auxiliary drug that promotes faster absorption of drugs administered intramuscularly;
• the drug is suitable for complex therapy of allergic rhinitis and neuritis;
• helps against ankylosing spondylitis;
• for rapid healing of postoperative, traumatic or burn scars.

The period of action of Lidase is two days from the moment of injection.

• Lyophilisate for the preparation of solution for injection and topical use

Active ingredient: hyaluronidase enzyme (64 UE in 1 bottle).

Lidaza helps improve the absorption of medications intended for subcutaneous and intramuscular administration. When combined with Lidaza, an increase in the effectiveness of a drug with a local anesthetic effect is observed.

The cost of the drug Lidaza for the period January 2019 is formed as follows:

• Bottle 64ED, 1 pc. – 230-240 rub.
• Ampoules 64UE, 10 pcs. – 370-390 rub.

The following drugs can be used as analogues of Lidaza: Ronidase, Bioginal, Hyaluronidase.

Lidase powder is white in color and is prepared by lyophilization (drying a solution under vacuum). The main active ingredient of the drug is the enzyme hyaluronidase, its content in one ampoule is 64 IU (units of action).

Ampoules with Lidaza powder are packaged in packs of 10 pieces. A cardboard box contains one package of ampoules and instructions for use of the drug.

The shelf life of Lidaza powder is 2 years from the date of its manufacture. After preparing the solution, it must be used within an hour. Unopened ampoules should be stored in a dark place, protected from light, at an air temperature no higher than 15º C.

The drug is made from the testes of cattle. It is based on the enzyme hyaluronidase and auxiliary substances.

Currently, this drug is available in several forms:

• lyophilisate for solution preparation, for injection and topical use;
• lyophilisate for preparing a solution for local and external use;
• powder for external use.

Lidaza is also produced in the form of suppositories, but not on an industrial scale, but according to a special prescription from a specialist, which the patient must bring to the pharmacy.

This drug enhances the effect of (local) anesthetics and is often used to improve the absorption of drugs.

Lidase is recommended to be used very carefully when used concomitantly with other medications, since there is a high probability of increased absorption, which cannot be predicted, and it is also possible to enhance the systemic effect.

The drug is dispensed in pharmacies with a prescription from a specialist.

The drug should not be stored at high temperatures and high humidity. The optimal storage temperature is up to 25 Celsius.

“The gynecologist prescribed me Lidaza suppositories. The first two times after using it I felt slightly nauseous, but then this unpleasant condition passed and I felt noticeable improvements. I completed the full course (10 applications) and the adhesive process stopped bothering me. The doctor confirmed the improvement. I am pleased".

It must be said that in most cases this drug is prescribed in the form of injections, including in gynecology, and there are also many reviews about this form of use of the drug. People often complain that the first few procedures bring discomfort and even pain, but later these symptoms go away and experts say that this is quite normal.

According to experts, Lidaza injections in gynecology help relieve women of many problems in this area, therefore, despite the doubts of some people, this drug is actively prescribed and has a truly effective effect in the treatment of many diseases.

In cosmetology, Lidaza is used to treat inflammatory processes, as well as to accelerate the absorption of substances that are administered intramuscularly and subcutaneously.

The RLS directory indicates that the drug is produced in different countries. The Latin name is Lidasa. This is a powder that is intended for the preparation and administration of a solution in the form of injections. One ampoule contains 64 units (U) of hyaluronidase. This substance is obtained from the testes of cattle.

There are no auxiliary components of the composition. The drug is presented in the form of a powder, which is compacted into a tablet or lyophilized porous mass. It has a white or cream tint. A hard, dry crust is allowed to form on the surface. The price of Lidaza ampoules is about 300 rubles.

The medicine is produced in the form of a lyophilisate. A solution for injection is prepared from it. The drug can be used topically. The pharmacy sells glass bottles in 5 ml packaging. They are carefully closed with a rubber stopper, as well as a rolled aluminum cap. The concentration of the drug is 64 units.

One package contains 10 bottles. The manufacturer provides printed instructions for use. The package includes a solvent. This is a bottle containing 5 ml of 0.9% sodium chloride solution.

The drug Lidaza can enhance the effect of using local anesthetics. When treating with several medications simultaneously, you need to study their composition, as well as their compatibility. For advice, I turn to a therapist or a doctor of a narrow specialization who deals with treatment. Lidaza improves the level of absorption of drugs that are injected under the skin or inside the muscle.

Before starting therapy, it is important to conduct a quick test for the body's allergic reaction. 20 μl of hyaluronidase is injected into the skin and wait about 10-15 minutes. If there is no redness and irritation, then the patient can be prescribed treatment in full dosage.

This medicine is well tolerated, but it is forbidden to give injections or lotions to the area of ​​infectious inflammation, as well as areas with a tumor. Hyaluronidase is not used during the progression of acute forms of hemorrhage.

Doctors and patients leave positive reviews about the drug Lidaza. It is distinguished by its effectiveness and quick results in comparison with other means.

Elena. Lidaza helped me get rid of a scar on my left leg. It was old, received in childhood. To remove the rough area of ​​skin, electrophoresis with Lidase solution was prescribed. It was not possible to completely get rid of the scar, but the damaged area became soft, the scar smoothed out and became almost invisible. In the summer this area became tanned, although previously it had always remained white. The medicine is inexpensive, but it can be injected or used externally.

Victoria. A course of Longidase suppositories was prescribed after a caesarean section. I was bothered by pain in the pelvic area. Sometimes I had difficulty sitting on a chair or hard surface. I went to see a gynecologist and underwent a comprehensive examination. I was diagnosed with postoperative adhesions in the pelvis.

The doctor prescribed a course of Lidaza in suppositories. I read useful recommendations in the instructions for use and received advice from a doctor on proper use. I noticed the first result after 10 days of use. My husband was prescribed this drug to treat prostatitis. I know cases where friends used ampoules in cosmetology to get rid of acne. But the difference between this medicine and other drugs is that it can only be purchased with a prescription.

Catherine. I have great confidence in this drug. I was recovering from surgery to remove appendicitis. A colloidal rough scar appeared above the skin, which was blue-burgundy in color. I immediately began to sound the alarm and went to the doctor for a consultation. I was prescribed three courses of Lidaza injections and aloe lotions.

Generics

Substitute drugs for Longidase are:

1. "Lidaza".
2. "Polyoxidonium"
3. "Ronidaza."
4. "Biostrepta".
5. "Distreptase".
6. "Liraza."
7. "Laproth."

An analogue of Longidase in tablets is Polyoxidonium.

Longidaza should be kept away from children. The medicine should be kept at a temperature of 2 to 15 degrees, away from light, in a dry place. Shelf life – 24 months.

Powder for making injections is available with a prescription, suppositories are available without a prescription. The cost of the drug varies from 1500 to 3000 rubles. - Russian pharmaceutical.

What is the drug

The medication belongs to the group of enzymes and has two forms of release

In the treatment of prostatitis, the drug acts as follows:

• eliminates inflammation;
• eliminates congestion and restores normal blood circulation;
• prevents the proliferation of connective tissue, has an antiphymotic effect.

It also has additional properties:

• destruction of affected cells, removal of toxins from the body, elimination of pathogenic microorganisms, cleansing, antibacterial activity;
• providing an antioxidant effect, normalizing fat oxidation processes;
• increased interferon production, improved immunity and increased body resistance to infections.

Among the advantages of the medicine, it is worth noting the following:

• It copes well with chronic prostatitis regardless of age.
• Strengthens the immune system, increases endurance and resistance of the body.
• Improves potency and increases reproductive capabilities.
• Normalizes the state of the nervous system and helps cope with psychological discomfort.
• It quickly helps relieve pain.
• There are a number of studies that have confirmed its effectiveness.
• The shape of the candles is the most effective and convenient to use.

Analogs of Longidaza suppositories

Analogues are determined by structure:

1. Lidaza.
2. Lidaza-M.
3. Ronidaza.

The average cost of Longidaza (suppositories 3000 IU No. 10) in Moscow is 1,735 rubles. Lyophilisate for preparing a solution - 2030 rubles for 5 bottles. Lyophilisate is available with a prescription, suppositories are available without a prescription.

Keep away from children. Store at a temperature of 2-15 C in a dry place, protected from light. Shelf life – 2 years.

No information.

List of Longidase analogues

Since the medicine has a high price, many are trying to find analogues with the same effect. There is no exact structural analogue in pharmacies, but a number of drugs are prescribed for similar indications:

In addition to suppositories, Longidaza is sold in the form of a lyophilisate; the indications for use of this drug are the same, therefore analogues can be selected in this form.

Lidaza - an inexpensive analogue

Lidaza is also a Russian drug, available in the form of a lyophilisate for topical use or preparation of an injection solution. Lidase refers to a means for activating metabolism in tissues.

The product contains the enzyme hyaluronidase, isolated from the testes of cattle.

The medicine improves the movement of intercellular fluid, removes swelling, and helps scars and adhesions resolve.

Indications for use include injuries, burns, ulcers that do not heal for a long time and become covered with scars. The drug can be injected into joints with contractures, arthrosis, or damage to intervertebral discs. The drug is widely used in ophthalmology, pulmonology, and cardiology. It is contraindicated for tumors, pulmonary hemorrhages, and tuberculosis.

Longidase analogue Trypsin

Despite being part of the same group of drugs, Trypsin has a different composition - it is made from cow pancreatic enzymes. The product is sold in the form of a lyophilisate or a porous mass compressed into a tablet.

Trypsin does not show activity on healthy tissues, since they contain its inhibitors, and the substance does not affect the hemostatic system. But on tissues affected by fibrous formations, in the presence of edema, exudate, viscous secretion, it exhibits its properties

:

• decongestants;
• absorbable;
• anti-inflammatory.

Trypsin is recommended for adhesions, abscesses in the lungs, bronchi, after operations, for the treatment of burns and purulent wounds, osteomyelitis, and periodontal disease. It is used in ophthalmology, urology. It is forbidden to inject the product into bleeding cavities or ulcers caused by cancerous tumors.

Chymotrypsin as a replacement for Longidase

The drug is similar in composition and action to Trypsin; it is also obtained from the pancreas tissue of cows. The substance hydrolyzes proteins with the appearance of low molecular weight peptides, which affects the process of splitting foci of necrosis and fibrous cords (adhesions).

After administration, the medicine dilutes blood clots, thick exudate and has an anti-inflammatory effect.

It can even be used for inhalation, but there is a risk of irritation of the respiratory tract.

In addition to diseases of the bronchi and lungs, the remedy is indicated for burns and purulent wounds, thrombosis, sinusitis, and can be used in gynecology. Chymotrypsin can cause tachycardia and increased body temperature.

Polyoxidonium in suppositories

This drug can also replace Longidaza, especially since it is sold in a convenient form - suppositories. Polyoxidonium is a strong immunostimulant and increases the body's resistance against various infections. It directly affects phagocytes and killer T cells, which serve as the central link of the immune system.

The drug also increases the rate of antibody formation, restores the integrity of the skin and mucous membranes after burns, injuries, radiation therapy, removes toxins, and is an antioxidant. The main indications for suppositories are:

• secondary immunodeficiencies;
• chronic inflammatory and infectious diseases;
• acute infections;
• urethritis, cystitis, nephritis;

The drug is contraindicated for children under 6 years of age, pregnant women, and lactation. There are no other contraindications for treatment. Polyoxidonium can serve as a substitute for Longidase only with the approval of a physician.

Source:tubik.net

Longidaza is a Russian-made enzyme product that is used in the treatment of urological, gynecological, pulmonological, surgical, and orthopedic diseases.

The longidase enzyme restores tissue, makes it more elastic and mobile, and also accelerates the healing of wounds and hematomas. The medication has an immunomodulatory and antioxidant effect. The drug has the following indications: adhesions in organs responsible for reproduction, cystitis, prostatitis, scars after operations, joint diseases, scleroderma, tuberculosis, pulmonary sclerosis. Release form: suppositories, powder for internal administration.

Reviews about "Longidaza"

Patients leave only good reviews about the drug. Both suppositories and lyophilisate show increased effectiveness with fresh adhesions, and also help resolve old scars and prevent the formation of new ones.

For women, as a rule, the medication helps with gynecological diseases. Longidaza helps eliminate adhesions, helps with ovarian cysts, and is also an effective drug for endometriosis. There are responses that say that after treatment of gynecological ailments with Longidase, pregnancy finally occurred. Men also respond positively to Longidase in the treatment of prostatitis. They especially note the absence of negative reactions and the ease of use.

As disadvantages, some patients point to the unpleasant smell of the candles, and when administering injections they talk about pain at the injection site.

Other foreign analogues

The medication given below acts as a high-quality replacement for a cheap imported drug similar to Longidase.

Hyaluronidase . An enzymatic medication that causes the breakdown of hyaluronic acid into glucosamine and glucuric acid, which causes its liquefaction.

The drug improves tissue and vascular patency, relieves swelling, causes resorption of adhesions and scars, and facilitates joint mobility. Country of origin: South Africa. The average price is 320–520 rubles.

Longidaza, its domestic and imported synonyms should be prescribed by the attending physician according to strict indications. Medicines improve the absorption of many drugs and require increased monitoring by a specialist.

Source zheleznaya-lady.ru

Longidaza is a drug that is available in the form of rectal and vaginal suppositories, as well as in the form of injections. It is prescribed for the treatment of gynecological and urological ailments, and is also used for orthopedic diseases.

The medicine relieves inflammation, acts as an antioxidant, improves immunity and improves joint function. Longidaza is sold at a high price, so people often look for cheaper analogues. Substitutes exist both among Russian drugs and in the list of foreign drugs.

Interactions with drugs

Longidaza can be used with antibacterial, antiviral, bronchodilator, antifungal agents, as well as glucocorticosteroids and cytostatics.

Adrenocorticotropic hormone, cortisone, and increased concentrations of estrogen can reduce the effect of the hyaluronidase enzyme. The drug increases the effect of local anesthetic drugs. What can replace Longidaza with?

Contraindications

What does Longidaza help with? Longidaza suppositories and injections are prescribed to adult patients as part of complex treatment, as well as for the prevention of diseases in which connective tissue hyperplasia is noted.

• Orthopedics: arthrosis, joint contracture, ankylosing spondylitis, hematomas.
• Gynecology: therapy and prevention of adhesions in the pelvic organs in diseases of an inflammatory nature (endometritis, infertility, intrauterine synechiae).
• Surgery: adhesions after operations, hypertrophic scars, wounds that do not heal over a long period.
• Urology: interstitial cystitis, chronic prostatitis.
• Cosmetology, dermatovenerology: keloid, developing, hypertrophic scars, limited scleroderma.
• Pulmonology, phthisiology: pneumosclerosis, tuberculosis, fibrosing alveolitis.

In addition, Longidaza is used to increase bioavailability when using certain antibacterial agents, as well as to enhance the effect of local anesthetics.

What is better, injections or suppositories, is determined by the doctor individually in each case. Before starting therapy, the patient must inform the doctor about the medications he is taking.

• Malignant tumors.
• Hypersensitivity/individual intolerance to the components of the drug.
• Acute infectious diseases.
• Hemoptysis.
• A history of pulmonary hemorrhage.
• Severe renal failure.
• Pregnancy.
• Age up to 12 years.
• Fresh hemorrhages into the vitreous body.

Women who are breastfeeding should use Longidaza suppositories only under the supervision of a physician. In case of severe liver failure, the drug should be used with great caution (there is a risk of developing pulmonary hemorrhage). If kidney function is impaired, suppositories are allowed to be used no more than once a week.

DETAILS: Antifungal drugs in urology

In medicinal protocols for various pathologies, Longidase suppositories can be used as a component of complex therapy, or as a single monotherapy drug. The main indication for the use of this drug is excessive new formation of structural elements of connective tissue - hyperplasia. Longidaza suppositories, despite the rather high price, are a popular drug in six branches of medicine. Let's look at them separately.

In gynecological practice, this drug, in most cases, is the main component of the treatment of adhesions that occur as consequences of inflammatory and chronic diseases of the pelvic organs. In addition, Longidaza suppositories are used for intrauterine synechia, chronic endomyometritis and tubo-peritoneal infertility.

Longidase suppositories are used for:

• chronic prostatitis – inflammation of the prostate gland of a chronic nature;
• interstitial cystitis, also known as painful bladder syndrome;
• narrowing of the lumen of the urethra (urethra) and ureters - stricture,
• Peyronie's disease - deformation of the penis due to the proliferation of fibrous tissue;
• benign prostatic hyperplasia at the initial stage.

It is also quite common to use Longidase suppositories to prevent scars that can occur after surgery on urological organs.

In this industry, Longidaza is prescribed in the postoperative period as therapy or prevention of scars. The drug is also used to prevent the development of adhesions after surgery on the abdominal organs, for the treatment of non-healing wounds, trophic ulcers and adhesive disease.

The main indication for the use of Longidase in orthopedics is joint contracture. This pathology is a limitation of passive joint mobility, caused by cicatricial tightening of tendons or skin. In addition, in orthopedic practice the drug is prescribed for arthrosis, hematomas and ankylosing spondylitis - a chronic systemic pathology of the joints, which is also called ankylosing spondylitis.

The main pathologies for the treatment of which Longidaza suppositories are used in pulmonology and phthisiology are:

• infiltrative tuberculosis is a form of tuberculosis characterized by inflammatory changes in the lungs of an exudative nature;
• cavernous fibrous tuberculosis is a form of pathology that is accompanied by the development of a fibrous cavity;
• pneumosclerosis - a disease caused by the replacement of lung tissue with connective tissue;
• tuberculoma - tuberculosis with a characteristic round formation in the lungs;
• alveolitis - infection and subsequent inflammation of the hole in the gum that forms after tooth extraction;
• pulmonary fibrosis – respiratory dysfunction caused by an increase in the volume of connective tissue in the lungs;
• siderosis is a pathology of the lungs, which is provoked by iron-containing dust settling in the respiratory organs;
• pleurisy is an inflammatory disease of the pleural layers;
• interstitial pneumonia is an inflammatory disease of the lungs, which is characterized by damage to the connective tissue around the alveoli.

In most cases, Longidaza suppositories are used in this branch of medicine to combat scars that are the result of injuries of various types. This drug is also prescribed for:

• scleroderma - an autoimmune pathology of connective tissue, which manifests itself as a characteristic skin lesion;
• pyoderma - purulent skin lesions.

Longidaza suppositories are not prescribed in the following cases:

• individual hypersensitivity or intolerance to the components of the drug;
• severe renal dysfunction;
• age up to twelve years;
• pregnancy and lactation period.

In addition, special caution in the use of Longidaza is needed in the acute course of any infectious disease (in such cases, Longidaza is prescribed only in combination with an antimicrobial drug), as well as in the case of patients who have recently suffered serious bleeding of any origin or are suffering from from renal failure.

Suppositories for vaginal or rectal use

Adults and adolescents over 12 years of age in the form of monotherapy and as part of complex therapy for diseases accompanied by connective tissue hyperplasia (including against the background of an inflammatory process).

Longidaza is also used to increase the bioavailability of antibacterial therapy in urology, gynecology, dermatovenereology, surgery and pulmonology.

In urology:

• Chronic prostatitis.
• Interstitial cystitis.
• Strictures of the urethra and ureters.
• Peyronie's disease.
• The initial stage of benign prostatic hyperplasia.
• Prevention of scar formation and strictures after surgical interventions on the urethra, bladder, and ureters.

In gynecology:

• Prevention and treatment of adhesions in the pelvis in chronic inflammatory diseases of the internal genital organs.
• Prevention and treatment of adhesions in the pelvis after gynecological manipulations (including induced abortions, previous surgical interventions on the pelvic organs).
• Intrauterine synechiae.
• Tubal-peritoneal infertility.
• Chronic endomyometritis.

In dermatovenerology:

• Limited scleroderma.
• Prevention of fibrotic complications of sexually transmitted infections.

In surgery:

• Prevention and treatment of adhesions after surgical interventions on the abdominal organs.
• Long-term non-healing wounds.

In pulmonology and phthisiology:

• Pneumofibrosis.
• Siderosis.
• Tuberculosis (cavernous fibrous, infiltrative, tuberculoma).
• Interstitial pneumonia.
• Fibrosing alveolitis.
• Pleurisy.

Lyophilisate for preparing a solution for intramuscular and subcutaneous administration

In gynecology:

• treatment and prevention of adhesions in the pelvis in inflammatory diseases of the internal genital organs, incl. tubo-peritoneal infertility, intrauterine synechiae, chronic endometritis

In urology:

• treatment of chronic prostatitis, interstitial cystitis

In surgery:

• treatment and prevention of adhesions after surgical interventions on the abdominal organs
• hypertrophic scars after injuries, burns, operations, pyoderma
• long-term non-healing wounds

In dermatovenerology and cosmetology:

• treatment of limited scleroderma, keloid, hypertrophic, developing scars after pyoderma, trauma, burns, operations

In pulmonology and phthisiology:

• treatment of pneumosclerosis, fibrosing alveolitis, tuberculosis (cavernous fibrous, infiltrative, tuberculoma)

In orthopedics:

• treatment of joint contractures, arthrosis, ankylosing spondylitis, hematomas

To increase bioavailability:

• with the joint administration of antibacterial drugs in urology, gynecology, surgery, dermatovenereology, pulmonology, to enhance the effect of local anesthetics.

• malignant neoplasms
• children under 12 years of age (efficacy and safety have not been studied)
• increased individual sensitivity to the drug.

The drug is prescribed with caution for acute renal failure and pulmonary hemorrhages.

Longidaza is prescribed to adults and adolescents over 13 years of age. The drug can be taken either in combination with other drugs or separately. Longidaza suppositories, the indications for use of which are described in the instructions, are prescribed for certain diseases.

Urology

The medicine helps get rid of chronic prostatitis, and at this stage of treatment other drugs are also prescribed, since in combination with other drugs Longidaza gives an even greater therapeutic effect.

Chronic cystitis, including the acute stage, in this case the drug is used separately; only herbal medicines taken orally can be used in combination. Disturbances in the functioning of the ureters and urethra.

For such diseases, the medicine is used as a separate therapy; the use of other drugs in this case is possible only under the supervision of a doctor. Benign prostatic hyperplasia at the initial stage of its manifestation. As a preventive treatment for scarred tissue after surgery on the urethra, ureters and bladder.

Instead of Longidase in this case, doctors can prescribe treatment with Strovak.

Gynecology

Pharmacokinetics

Suction

When administered rectally, the drug is quickly absorbed into the systemic circulation and Cmax is reached after 1 hour. The bioavailability of Longidaza® rectal suppositories is at least 70%.

Distribution

The drug is characterized by a high rate of distribution: the half-life of distribution is about 30 minutes.

Metabolism

The drug penetrates into all organs and tissues (including through the blood-brain barrier and the blood-ophthalmic barrier). Does not accumulate in tissues.

Removal

T1/2 ranges from 42 to 84 hours. It is excreted mainly by the kidneys.

Registration numbers

suppositories for vaginas. or rect. administration of 3000 IU: 5 or 10 pcs. LSR-002940/07 (2001-10-07 – 0000-00-00)

Experimental determination of suitable drugs:

• LONGIDAZE
• GLUCOSAMINE + CHONDROITIN SULPHATE
• POLYOXIDONIUM
• CHONDROITIN SULPHATE
• CHONDROFLEX
• ARTRA
• HYALURONIDASE
• GLUCOSAMINE + CHONDROITIN SULPHATE
• POLYOXIDONIUM
• TERAFLEX
• CHONDROXIDE
• CHONDROITIN-AKOS

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ATX code for LONGIDAZ

V03AX (Other medicinal products)

Experimental determination of suitable drugs:

• LONGIDAZE 29.041 (Drug with proteolytic activity), Lyophilisate for…
• GLUCOSAMINE + CHONDROITIN SULFATE 16.031 (A drug that regulates metabolism in cartilage tissue) Stimulates regeneration…
• POLYOXIDONIUM 14.009 (Immunostimulating drug), Vaginal and…
• CHONDROITIN SULPHATE Clinical and pharmacological groups 29.016 (A drug with improving the regeneration of cartilage tissue and anti-inflammatory effect for…
• CHONDROFLEX 16.031 (A drug that regulates metabolism in cartilage tissue), composition…
• ARTRA 16.034 (A drug that stimulates the process of regeneration of cartilage tissue), composition and…
• HYALURONIDASE 29.041 (Drug with proteolytic activity) Enzyme agent isolated from the testes…
• GLUCOSAMINE + CHONDROITIN SULFATE Clinical and pharmacological groups 16.034 (Drug that stimulates the process of regeneration of cartilage tissue) 16.031 (Drug that regulates metabolism…
• POLYOXIDONIUM 14.009 (Immunostimulating drug), Vaginal and rectal suppositories1…
• TERAFLEX 16.031 (A drug that regulates metabolism in cartilage tissue), composition…
• CHONDROXIDE 16.031 (A drug that regulates metabolism in cartilage tissue), composition…
• CHONDROITIN-AKOS 16.035 (A drug that stimulates the process of regeneration of cartilage tissue, with an anti-inflammatory effect) Form…

Popular analogue

Longidaza is not a cheap drug. Therefore, many women are looking for cheaper analogues. Lidaza is considered the most common replacement. However, this medicine cannot be called a full-fledged analogue, since Longidaza suppositories in gynecology are equated in their composition to an almost unique medicine.

Lidaza is available as an injection. Helps reduce swelling of tissues, promotes their permeability and elasticity. It softens scars well. The use of the product during breastfeeding and pregnancy is prescribed exclusively by a doctor. Therapy is carried out under the strict supervision of a specialist.

It is prohibited to get carried away with the medication. So, the following symptoms may occur:

1. Vomit;
2. Painful rapid heartbeat;
3. Nausea;
4. Minor swelling;
5. Shiver;
6. Headache;
7. Loss of balance.

Video about treatment with suppositories

In this video you will learn about the treatment of ovarian cysts:

Source medic-23.ru

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

How to use candles?

When treating with medication, the following scheme is practiced. In the first 5 days, one suppository should be administered before bedtime. Then, over the next 10 days, the suppository is administered before bedtime, but every other day. The course of treatment is one package of suppositories, that is, 10 rectal suppositories. On the recommendation of the attending physician, the dosage regimen may be changed and the course may be increased.

To prevent exacerbations, suppositories are used every other day two to three times a year. The preventive treatment regimen depends on the form of inflammation and concomitant diseases. The medicine cannot be used on an ongoing basis; a two to three month break must be taken between courses of treatment.

As an independent remedy, Longidaza is used only for prevention. The drug cannot relieve acute inflammation and swelling; it only increases the effectiveness of other medications and stimulates the immune system, therefore it is used in addition to antibacterial therapy.

Use for exacerbation

Exacerbation of chronic prostatitis is characterized by increased pain, increased pressure of the organ on surrounding tissues and impaired urination. During an exacerbation, it is important to relieve inflammation as early as possible, which is why antibiotics are used in therapy.

Longidaza during exacerbation helps improve the effectiveness of antibacterial therapy. The treatment regimen does not change - a rectal suppository is also administered daily before bed for the first five days. Reviews from patients note the good interaction of suppositories with such popular drugs as Ceftriaxone and Levofloxacin.

The effectiveness of combination therapy is due to the ability of Longidase to reduce swelling of the prostate and remove excess fluid from the body. This makes it possible to improve the transport of antibiotics directly to organ tissues.

As practice shows, the simultaneous use of rectal suppositories with Ceftriaxone helps relieve acute inflammation in an average of one week, while the use of only an antibiotic requires a minimum of two weeks of treatment. Despite this effect, you cannot independently reduce the dosage and duration of taking antibacterial drugs; any decisions to adjust the dosage are made only by a urologist.

Longidaza increases the effectiveness of antibiotics

Use for prevention

For preventive purposes, Longidaza should be taken a maximum of three times a year. The suppository is administered rectally before bedtime. Dosage regimen: 1 candle every other day. In total, 5 suppositories must be used for prevention.

Longidaza increases local immunity and improves tissue trophism, thereby reducing the frequency of exacerbations of chronic prostatitis. To enhance the therapeutic effect, the doctor may recommend rectal suppositories together with herbal preparations to improve the functionality of the prostate gland.

For prostate adenoma, the treatment regimen is adjusted depending on the size of the hyperplasia. At the second stage of adenoma, injections of the drug are indicated, since suppositories are not effective enough due to absorption in the intestine, while the solution enters directly into the blood.

Contraindications to the use of Longidaza suppositories

Gynecology

Longidaza is taken for limited scleroderma, promotes the healing of hypertrophic scars, as well as colloidal scars. The medicine is prescribed as a prevention of complications caused by genital tract infections.

Surgery

It is used for the preventive treatment of adhesions formed after surgical interventions on the abdominal organs, as well as for the treatment of wounds that do not heal for a long time.

Pulmonology

Longidaza is prescribed for tuberculosis, pneumonia, pleurisy, alveolitis, siderosis.

Contraindications:

• Longidaza is not prescribed to patients with pulmonary hemorrhages, when a person is forced to cough up blood clots.
• The medicine should not be taken in a condition in which a person has hemorrhage in the vitreous body.
• In the case of malignant neoplasms, the drug may worsen the patient's condition and promote tumor development or enable cancer cells to progress faster.
• In acute renal failure, the drug is contraindicated, since large volumes are excreted in the urine.
• The medicine can cause irreparable harm to pregnant women and women during lactation. There have been cases where the active substance of the drug reduced the mental performance of the fetus and caused intoxication of the mother during pregnancy.
• The medicine is not prescribed to children under the age of twelve.
• If a person has hypersensitivity to the components of the drug, otherwise a severe allergy may occur.

With caution and under the supervision of a physician, the drug can be taken by patients diagnosed with chronic liver failure. A high concentration of the active substance is observed in the liver.

The drug should not be taken if the patient has acute renal failure. If it is necessary to take this medication, it should be taken no more than once a week, under the supervision of a doctor.

Side effects

Longidase may cause adverse reactions in some patients, and they can also occur if the patient does not follow the dosage prescribed by the doctor. A person from the drug may experience itching on the skin, redness, swelling in the place where the injection was given, and allergies. As a rule, mild adverse reactions stop on their own within 2 days.

If the patient has an allergy, in this case the drug should be discontinued and the attending physician should be notified so that he can select a similar remedy. To avoid side effects, before you start taking Longidaza suppositories, the indications for use should be carefully read in the instructions.

Reviews

Doctors evaluate the drug ambiguously - some note the effectiveness of the drug in gynecology and urology, others note the difficulty of objectively assessing the result, which makes Longidaza appropriate only in combination or prevention.

Based on patient reviews, the following conclusions can be drawn:

• for urological and gynecological diseases, the drug is often prescribed in the form of suppositories. Injections are chosen in situations where it is difficult for the patient to maintain the interval (injections have a longer lasting effect);
• Regardless of the form of release, Longidaza promotes the resorption of small adhesions and the elimination of tubal infertility. For large, old adhesions it is not always possible to do without surgery, but injections relieve pain;
• the drug is effective in the treatment of acute and chronic prostatitis (increases the interval between exacerbations), as well as cystitis;
• injections go well with antibacterial agents and physiotherapy;
• to combat non-healing post-operative wounds, 5 injections may be sufficient;
• a number of patients found the injections painful;
• side effects (nausea and dizziness) occur rarely and do not lead to discontinuation of treatment;
• After injections, bruises and slight swelling may remain, disappearing only after a week.

All patients note the high cost of treatment. Longidaza is a drug based on a natural enzyme that has no analogues and produces a minimum of side effects.

The injections are especially effective for preventing adhesions and scarring and combine well with antibiotics.

The drug is safe when used according to instructions.

Article design: Svetlana Ovsyanikova

Belarusian generics

There is an effective modern Belarusian generic of Russian lidase, under the same name. The table contains a brief description of the medicine and approximate prices in domestic pharmacies.