Nolpaza for pancreatitis: reviews, instructions for use

Directions for use and doses

Nolpaza is intended for oral administration before breakfast. The tablets are swallowed without chewing and washed down with 2-3 sips of water.

The regimen for taking Nolpaza is determined by the doctor depending on the patient’s condition. The standard dose of the drug for exacerbation of pancreatitis is 40 mg once a day. For patients in whom inflammation of the pancreas is combined with gastric ulcers or other chronic gastrointestinal pathologies, the doctor may increase the daily dosage of pantoprazole to 80 mg. In this situation, the remedy should be taken twice a day (before breakfast and dinner).

Switched from Omez to Nolpaza.

Hello everyone) I would like to share a review about the drug Nolpaza 20 mg.
I discovered it for myself just a year ago. Before this I always used Omez.

My pancreas worries me very much from time to time. Sometimes for six months I completely forget about it, but at some point, wild pain and a feeling of fullness begin, characteristic of pancreatitis. This usually happens when there is an error in nutrition, that is, I overeat or eat a lot of fatty foods.

One time it got to the point where I had a fever. Before this incident, I didn’t even imagine that it could rise because of the pancreas. But I felt very bad then.

Previously, I always went on a strict diet, of course, and used Omez.

This time, the new doctor prescribed me Nolpaza along with other drugs.

My question is, what about Omez? — she explained that Nolpaza was prescribed to me instead of Omez.

It turns out Nolpaza is a newer and more effective drug.

It contains another active substance - pantoprazole.

But it has the same effect as omeprazole, a specific proton pump inhibitor.

That is, it blocks the final stage of hydrochloric acid synthesis.

I was treated for two weeks in total. But relief came to me within three days. The heaviness and pain are gone. The temperature also dropped. I took Nolpaza twice a day. In the morning before meals and in the evening. But this is in my case when I delayed everything too much. For mild cases, take one tablet once a day in the morning.

Almagel A also helped me well with this treatment. I also wrote a review about it here:

According to my feelings, when treated with Nolpaza, my symptoms of pancreatitis disappeared significantly

faster than when taking Omez. I repeat that after three days I already felt normal and was able to work. With Omez, my treatment was more extended in time.

Therefore, I personally recommend Nolpaza to everyone who has similar problems.

And to those who doubt the choice between Nolpaza and Omez. Try a newer drug.

But it’s better, of course, live without pills and be healthy)))

Often, for pancreatitis, doctors prescribe Nolpaza to reduce stomach acidity and relieve symptoms of mucosal inflammation.

Side effects

Undesirable effects from the drug Nolpaza may occur:

• painful sensations in the abdominal area;
• bowel dysfunction (diarrhea, constipation);
• nausea;
• flatulence;
• vomiting syndrome;
• dizziness;
• headache;
• blurred vision;
• allergic reactions (itching, rash or urticaria on the skin, Quincke's edema, anaphylaxis, erythema multiforme, Steven-Johnson syndrome);
• depression;
• muscle or joint pain;
• interstitial nephritis;
• blood diseases (thrombocytopenia, leukopenia).

In some patients, Nolpaza may cause increased body temperature, weakness, swelling of the extremities, or pain in the mammary glands.

Side effects of the drug also include its negative impact on driving. If a person drives a car or does other work that requires concentration, he should not take these tablets.

Indications for use of Omez

It is very important to perform an endoscopic examination of the stomach and intestines before using Omez. It is imperative to exclude the presence of pathological tumors. Since, the use of Omez can blur and mask the clinical picture of oncological pathology.

Omez is prescribed in the following cases:

1. Peptic ulcer, which appears under the influence of psycho-emotional factors and stressful situations.
   Pathological conditions of the stomach and intestines , accompanied by the development of ulcers and erosions.
2. When it is necessary to treat side effects from the use of non-steroidal anti-inflammatory drugs.
3. Peptic ulcer, which appears under the influence of psycho-emotional factors and stressful situations.
4. Zollinger-Ellison disease.
5. Erosive lesions of the upper part of the stomach and esophagus.
6. Infectious diseases that reduce the amount of positive microflora of the mucous membrane of the stomach and intestines.
7. Treatment of the consequences of negative symptoms of gastritis (heartburn, acid belching, increased gas formation).

Omez in capsule form has the same scope of application as lyophilized powder for parenteral use. With intravenous drip administration, a more prolonged and rapid effect from the use of Omez is observed.

Composition and release form

Nolpaza is a drug from the group of proton pump inhibitors containing the active component pantoprazole, presented in the form of sodium sesquihydrate. The dosage of this substance in one tablet is 20 or 40 mg. The list of inactive components of the drug includes mannitol, crospovidone, sodium carbonate, calcium stearate and sorbitol. The tablet shell is made using propylene glycol, hypromellose, talc, macrogol 6000, povidone, Eudragit L30D dispersion, food colors E171 and E172.

When is the drug used?

• Nolpaza is prescribed by doctors for peptic ulcers of the stomach and duodenum, and for other pathologies of these organs;
• to relieve symptoms similar to gastroesophageal reflux disease;
• in combination with antibiotics to destroy Helicobacter pylori (bacteria).

In most cases, it treats diseases and inflammations of the stomach and related organs. To prevent a negative reaction from the stomach, gastroenterologists suggest using the medicine for acute and chronic pancreatitis in adults.

Conditions for dispensing from pharmacies

Nolpaza is sold according to a prescription.

• Omeprazole for pancreatitis: instructions for use
• Application of Pariet for pancreatitis
• How to take Nexium for pancreatitis?
• Mexidol for pancreatitis

I often suffer from exacerbations of pancreatitis: as soon as I eat something wrong, abdominal pain, belching, and intestinal upset immediately appear. The doctor advised taking Nolpaza tablets at the first signs of pancreatitis. This remedy begins to act within an hour and a half after administration. After a 14-day course of treatment with Nolpaza, I completely forgot about my chronic pancreatitis. Now I keep the pills ready. If the disease suddenly worsens again, I will immediately start taking them.

Previously, during exacerbations of pancreatitis, I took Omez, but one day I noticed that it began to cause side effects for me. I told my gastroenterologist about this, and he replaced Omez with Nolpaza. This medicine is also a proton pump inhibitor, but has a different composition. Nolpaza is not inferior in effectiveness to Omez, it acts quickly and safely. During the entire time I took it, I never noticed any of the side effects listed in the instructions.

During the next attack of pancreatitis, as prescribed by the doctor, I started taking Nolpaza tablets, the effect of which is aimed at normalizing the acidity of gastric juice and reducing the load on the pancreas. I was disappointed with the drug, because while taking it I felt dry mouth, dizziness and constant hunger. I took the medicine for 5 days and quit because I felt worse and worse during treatment. Instead of the drug Nolpaza, the doctor prescribed tablets based on another active ingredient. They helped cure pancreatitis.

Hello! Please advise me on this issue, because... I really trust your opinion, and my further treatment and quality of life will depend on it. About 5 months ago, the following symptoms began to bother me: belching, nausea, pain in the left hypochondrium after eating, bloating, rumbling, gurgling in the stomach, a feeling that food was not being digested properly. In the morning, the stomach is also swollen, there is rumbling, discomfort in the left side, a white coating on the tongue. All this is accompanied by general weakness. Against this background, the stool became ointment-like, greasy, sometimes with pieces of undigested food. At the moment the status has not changed. Due to personal circumstances, it was not possible to immediately see a doctor. During this time, I tried to treat myself (because I suspected that it was gastritis and dysbacteriosis) with the following drugs: omez, de-nol, pancreatin, alpha-normix, bifidumbacterin, bifiform; but the condition has not changed. I tried motilium, ganaton, but these drugs caused pain in the mammary glands and the release of colostrum. 20.05. I went to see a doctor, and based on my complaints, she suggested that I go to a hospital for examination. I give you the results:

Analogues of the drug

Substitutes for Nolpaza in terms of the functioning component and mechanism of influence include:

1. Zovanta.
2. Zolopent.
3. Controll.
4. Pangastro.
5. Panazol.
6. Pantaz.
7. Panocyte.
8. Pantralis.
9. Panum.
10. Ulsepan.

Another group of analogs is similar in the mechanism of influence, but differs in the active element (they contain omeprazole):

• Hasek.
• Diaprazole.
• Omez.
• Omenax.
• Mistletoe.
• Omeprazole.

Also among the analogues there are groups with the active ingredients dexlansoprazole, rabeprazole, esomeprazole, etc.

One of the most frequently prescribed analogues of Nolpaza is the drug Omez. Despite the different active ingredients, the drugs have the same pharmacological effect. It is impossible to say for sure which drug is better. They are similar in their effects, list of indications and contraindications. However, according to the instructions, Omez has a slightly wider list of indications and includes ulcerative pancreatitis and peptic ulcers. Nolpaza is considered a drug of a newer generation. However, Omez has more positive reviews from patients. Regarding the price, Omeza costs almost half as much.

In any case, you cannot change medications yourself. This is the exclusive prerogative of the doctor.

Treatment of chronic pancreatitis.

Treatment of chronic pancreatitis during remission includes:

I. Strict adherence to diet. Since it is errors in the diet that become the trigger for each subsequent exacerbation, and each exacerbation leads to the irreversible loss of functioning pancreatic cells, it becomes clear that following a diet is a very important point in maintaining the functioning of the organ.

The patient should avoid drinking alcohol, fatty, fried, smoked foods, canned food and marinades. Preference in food should be given to steamed or boiled foods.

You should limit your intake of dairy products (milk, cheese, cottage cheese, etc.) to 200 ml per day.

For meat, you should give preference to lean beef (rather than pork), lean poultry (chicken, turkey, etc.). You can eat non-fatty fish, black caviar.

Vegetable soups containing cereals should be prepared.

When preparing porridge, you can add a small amount of milk, or cook it in water.

You should limit your consumption of products made from yeast dough (they are allowed to be eaten no more than once a week), but you can use dry cookies, stale white, and black bread in your diet.

The daily diet of patients with chronic pancreatitis should contain no more than 1 chicken egg per day. You can make a steam omelet from eggs.

II. Replacement therapy with enzyme preparations. In chronic pancreatitis, glandular tissue is replaced by connective tissue, resulting in disruption of the enzymatic function of the pancreas. For this reason, many patients require medications containing lipase, amylase, trypsin, and chymotrypsin. A doctor should select the dose of enzyme preparations, since their overdose can lead to the development of intestinal inflammation (colitis).

Enzyme preparations should not be chewed, because they are covered with a special enteric coating that prevents the release of the active substance in the stomach. Otherwise, the enzymes are inactivated by acidic gastric juice before reaching the duodenum.

Since pancreatitis primarily decreases the production of lipase, the activity of the enzyme preparation is determined by the activity of the lipase. Therefore, the digital designation next to the name of the drug indicates the activity of the enzymes contained in the capsule.

Enzyme preparations include:

• Pancreatin - 250-500 mg, applied 3-6 times a day immediately before meals. Should be taken with water or fruit juice.

Pancreatin is included in many enzyme preparations: Panzinorm, Creon, Mezima Forte, Ermital, etc.

• Panzinorm 10000 - take 1-2 capsules with each meal, including a light snack. The maximum number of capsules per day is 15.
• Creon 10000/25000 – take 1 capsule with each meal.
• Mezim forte (Mezim forte 1000) - take 1-2 capsules with each meal, without chewing.

III. Eliminate pain. Often, patients with chronic pancreatitis are bothered by constant aching pain in the abdomen in the projection of the pancreas. Since there are several mechanisms for the development of pain syndrome (impaired outflow of pancreatic juice through the ducts, activation of enzymes inside the pancreas, etc.), drugs from several pharmacological groups can be used to eliminate pain.

1. Proton pump blockers. They suppress the production of hydrochloric acid in the stomach, which stimulates the secretion of digestive enzymes by the pancreas.

Proton pump blockers include:

• Omeprazole (Omez) - 20 mg 1-2 times a day;
• Lansoprazole (Lanzap, Acrilanz) - 30 mg 1-2 times a day;
• Pantoprazole (Nolpaza) - 40 mg 1 time per day;
• Rabeprazole (Pariet) - 20 mg once a day. If necessary, continuous administration at half the dose is possible.
• Esomeprazole (Nexium) - 20-40 mg once a day. Swallow without chewing and wash down with water.

2. H2-histamine receptor blockers:

• Famotidine (Quamatel) 20-40 mg 2 times a day.
• Ranitidine (Zantac, Ranisan) 150 mg 2 times a day.

3. Antispasmodics. These drugs reduce the pressure in the pancreatic ductal system, which leads to a decrease in pain in the patient.

Antispasmodic drugs include:

• Drotaverine (No-shpa, Spasmol) - 40 mg, 1-2 tablets. 2-3 times a day.
• Mebeverine (Duspatalin) - 200 mg 2 times a day 20 minutes before meals, drink without chewing.

4. Non-steroidal anti-inflammatory drugs. They reduce inflammation and prevent the destruction of glandular tissue of the pancreas.

The most commonly used NSAIDs for chronic pancreatitis are:

• Diclofenac (Voltaren, Ortofen) 75 mg 1-2 times a day orally for 2-3 weeks.

IV. Treatment of diabetes mellitus (if any). It is carried out according to a standard scheme, as a rule, with insulin preparations during the period of exacerbation and with the help of glucose-lowering tablets during the period of remission. A feature of the treatment of diabetes mellitus in pancreatic patients is a significant reduction in the need for hypoglycemic drugs (or the complete disappearance of clinical diabetes mellitus) against the background of enzyme replacement therapy.

Treatment of chronic pancreatitis during exacerbation.

Since exacerbation of chronic pancreatitis is a serious condition and can be aggravated by the development of hypovolemic shock and other serious complications, treatment of such patients in most cases is carried out in a hospital.

Features of the use of the drug

Treatment of pancreatitis is a very long process. To restore the functions of the pancreas and its ability to produce pancreatic juice, complex therapy is prescribed. Therapists and gastroenterologists prescribe therapeutic fasting and prescribe various types of medications in order to eliminate the symptoms of the disease and provide proper treatment.

Medicines for pancreatitis relieve pain, treat inflammatory processes in the pancreas, eliminate its insufficiency and prevent the development of complications. Patients are recommended to take sedatives and hormonals, choleretic and enveloping medications.

In parallel with Nolpase, antibiotics, antispasmodics and enzyme preparations can be taken for pancreatitis. Antacid effectiveness and the effect of painkillers do not change, the action of the active components is balanced and does not affect each other.

In other diseases with additional intake of drugs that contain substances that can be absorbed and exert their effect in an acidic environment, nolpaza reduces the effect of the latter.

Chronic pancreatitis: symptoms.

Patients with chronic pancreatitis are concerned about abdominal pain, indigestion and endocrine disorders (diabetes mellitus, hypoglycemic conditions).

Pain. The vast majority (85%) of patients experience pain in the upper abdomen. In the first years of the disease, it is often intense and burning. With a long-term illness, the pain becomes less pronounced. It can be diffuse, encircling, but more often the unpleasant sensations are localized in the left or right hypochondrium, or in the epigastric region. Many patients notice a connection between pain and food intake: it appears or intensifies 20-30 minutes after eating and is often provoked by a diet violation: eating fatty, spicy, baked foods, raw vegetables and fruits (especially citrus fruits). In some cases, the pain may be constant and not go away even between meals.

All patients with chronic pancreatitis have indigestion to one degree or another, since the pancreas produces enzymes involved in the digestion of fats (lipases), carbohydrates (amylase), and protein (trypsin, chymotrypsin). Abdominal bloating, increased gas formation, flatulence, rumbling in the stomach, belching, and nausea appear. There may be vomiting, which does not bring relief.

A characteristic symptom of chronic pancreatitis is a change in the nature of stool: it becomes frequent (2-4 times a day), copious, has a pasty consistency, gray color, and a foul odor. Often, with severe deficiency of the enzymatic function of the gland, feces become shiny in appearance and are poorly washed off the walls of the toilet, because contains a large amount of undigested fat. No less typical for patients with pancreatitis is the alternation of diarrhea and constipation.

Since both pain and dyspeptic symptoms are usually associated with food intake, many patients begin to eat less and less often. Poor digestibility of food and malnutrition leads to weight loss in patients (with severe impairment of the enzymatic function of the pancreas). In addition, in severe cases, hypovitaminosis A, D, E, K may occur. For this reason, patients with chronic pancreatitis may experience bone pain, deterioration of night vision, and neurological disorders.

In some patients, the islets of Langerhans, in which insulin and glucagon are synthesized, are destroyed. If insulin production suffers more, the patient develops diabetes mellitus - blood glucose levels rise, thirst, excessive urination, and the need to eat large amounts of food appear. When the pancreas is unable to provide the proper level of glucagon in the blood, hypoglycemic conditions develop: ravenous hunger, severe weakness, body tremors, and sweating. Hypoglycemia can cause serious harm to the brain, which relies on glucose for nutrition.

With an exacerbation of chronic pancreatitis, all symptoms worsen: the pain may become unbearable, cutting, the nature of the stool will change (diarrhea will most likely develop), and symptoms of diabetes may appear.

If the outflow of pancreatic enzymes from the gland is impaired, their partial penetration into the bloodstream may occur, which will lead to the development of life-threatening systemic complications, such as hypovolemic shock, acute renal failure, etc.

What does the pancreas produce?

Conventionally, several groups of pancreatic enzymes can be distinguished:

• nucleases (break down RNA and DNA, which are the basis of all nutrients);
• amylases (digest starch and glycogen, correct carbohydrate metabolism);
• Proteases are divided into three more groups: elastases - break down elastins and proteins; chymotrypsin and trypsin - regulate digestive processes, are a kind of digestive juice; carboxypeptidase - using a different mechanism, it breaks down substances in the same way as other proteases;
• steapsin (breaks down fats);
• lipase (aimed at processing some fats already processed by liver bile).

What is the difference

The main difference is the active ingredients included in the drugs. The active component of Nolpaza is pantoprazole, and the constituent base of Omez is omeprazole.

These drugs differ by country of origin. Nolpaza is a European medicinal drug that is produced in Slovenia, and Omez is produced in India.

The methods of influence are also different. Nolpaza is better absorbed and has a gentler effect on the gastrointestinal tract, which reduces the risk of side effects. It is best to take Nolpaza as a prophylactic agent, since long-term use is possible without consequences. It is allowed to take the drug during pregnancy and lactation.

Omez is a more aggressive drug that has an immediate therapeutic effect. Improvements are observed 30-40 minutes after omeprazole enters the patient’s body. Use is not recommended during pregnancy and childhood.

Patients often choose Omez, since it is several times cheaper than Nolpaza.

Information! When choosing a medicine for the treatment of pathological lesions of the gastrointestinal tract, it is necessary to take into account the opinion of experts (doctors and pharmacologists) and the severity of the disease.

Many medical specialists prefer Nolpaza, since this particular drug was developed according to European criteria. This is a more gentle remedy that is easily tolerated by patients during long-term treatment.

How are medications similar?

If a person suffers from a chronic form of a disease associated with the gastrointestinal tract, visiting a gastroenterologist is considered routine. It is possible that for the same diagnosis, the doctor constantly prescribes different medications. First, the therapy includes the drug Omez, a little later - Nolpaza.

To begin with, it is worth noting that both drugs belong to the same drug group, as a result of which they have the same indications for use. Let's consider for which pathological processes of the gastrointestinal tract Omez and Nolpaza are prescribed:

• The presence of inflammation of the mucous membrane of the organ of various etiologies.
• Gastroduodenitis with increased stomach acidity.
• The appearance of ulcers on the organ (including if the disease is caused by bacteria).
• The patient complains of chronic heartburn.

The drugs act on the body as follows: the active components of Omez or Nolpaza, when they enter the stomach, form a barrier that protects the organ from harmful effects. In addition, medications help normalize the acidity level of the organ.

Another similarity is ease of use. Both products contain the same amount of active ingredient. Omez and Nolpaza are drunk in the morning before meals.

The active substance works throughout the day, so drinking the product more than once a day is useless.