Buserelin Depot - instructions for use, doctors' reviews, price

1 Description of the drug Buserelin, instructions for use.
2 Side effects when using Buserelin
3 Contraindications for the use of Buserelin
4 How to take Buserelin for endometriosis?
5 The principle of action of the drug
6 Reviews of doctors and patients about Buserelin

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Buserelin Depot is an artificially created hormonal preparation of gonadotropin-releasing hormone. In most cases, it is used to suppress the synthesis of sex hormones , which in excess amounts can lead to endometriosis, fibroids or breast cancer.

Buserelin is used for the complex treatment of hormone-dependent malignant tumors in men and women. This product is available in the form of a nasal spray or solution for intramuscular injection. In the pharmacy, the medicine may be called: “Buserelin-depot”, “Buserelin-long” or simply “Buserelin”. This synthetic analogue of natural gonadotropin-releasing hormone is especially useful in the treatment of endometriosis (the main complication of which is infertility).

Description of the drug Buserelin, instructions for use.

Buserelin is a hormonal drug with antiandrogenic, antigonadotropic and antiestrogenic properties. As already mentioned, it has an antitumor effect by binding to the receptors of pituitary cells, causing a short-term increase in the level of hormones in the blood. By reducing the synthesis of testosterone, it has a suppressive effect on the synthesis of sex hormones . With a continuous course, the drug reduces inflammatory processes, the size of pathological tissue, and reduces its blood supply.

If you stop taking Buserelin, there may be irreversible consequences. This can lead to complications such as: further development of the disease, proliferation of tumors; transition of benign formations to malignant.

Reviews about "Buserelin"

“Buserelin,” according to reviews, is most often used in the form of a spray. The effectiveness of the drug is controversial. Some patients do find it effective, but many claim that certain unwanted reactions, including cysts, have occurred after use. "Buserelin", according to doctors, can only be used under the qualified supervision of the attending physician. However, it is often used in medical practice and helps in the treatment of uterine fibroids, hyperplastic endometrial processes and endometriosis, as well as tumor hormone-dependent processes of the genital area in women.

How to take Buserelin for endometriosis?

First of all, it is worth noting that the drug is a suspension for intramuscular administration . Buserelin is diluted right before injection . The ampoule comes with two needles with different colored caps. It is very important not to confuse their sequence , because the quality of the injection depends on this. A needle with a pink tip is used to draw up a solvent and inject it into an ampoule with a dry lyophilisate. The suspension is shaken and drawn into a syringe in a vertical position. After this, the needle is replaced with another one with a green tip and the injection is performed.

For endometriosis, Buserelin is administered once, at a dosage of 4.2 mg four times a month. As a rule, injections begin in the first five days of the menstrual cycle.

The course of treatment can range from 3-6 months . After this time, the patient is prescribed a general blood test and a hormone test, and a pelvic ultrasound is performed.

Buserelin-Depot

Diagnosis: uterine fibroids 7-8 weeks, endometriosis. They did a hysteroscopy, removed the polyp. They prescribed Buserelin Depot 6 injections. After the first injection, I didn’t notice any side effects, but my periods came, heavy, as usual. But after the second, strong hot flashes began. At night I didn’t sleep, I had a terrible headache, I tried all the pills for headaches, only Pentalgin helped. I lost 2 kg in a week, because... I felt sick and couldn’t eat. My blood pressure began to rise significantly, it reached 194/121, my pulse was under 100. I started taking Prestarium 5 mg. At night I had dry mouth, which caused a cough, my periods came scanty. After the third injection, the side effects were the same , nagging pain in the lower abdomen increased and my lower back began to hurt. I noticed a change in mood. Sometimes I wanted to cry for no clear reason. I went to the doctor, an ultrasound showed that the endometrium was normal, the fibroids remained the same. They prescribed Femoston 5 mg + 1 mg. once a day. After the third injection, my periods came VERY heavy, lasted for a week. I took the fourth injection, while taking Femoston, the side effects no longer tormented me, but the joints on my hands began to hurt. My periods came again, but they were more scanty, the duration was the same I had it for 7 days, there was a turmoil in my stomach, I’m still trying to cope with this with Linex, 6 tablets a day. Now I took the 5th injection, more pain in the joints, especially in the shoulders, drowsiness, it’s very difficult to get up in the morning, but no one canceled work. I’m waiting, what will happen next...they will come, they won’t come.....I don’t even know what to say yet, whether it’s worth using it or not. But it’s for sure that doctors need to take it more seriously and be more attentive to the patients who are prescribed this drug. that before this you need to undergo some additional tests, I’m not a doctor, I don’t know. I read a lot about this drug, about the reviews, I see that very often problems begin in the mammary glands, often leading to operations. I also have pain, but I’ve had fibrocystic mastopathy for a long time, I’m being monitored, but after the sixth injection I want to get checked unscheduled, on my own initiative. It feels like now it’s being prescribed at random, it will help, it won’t help... Well, we can only hope and believe... HEALTH to everyone ,girls!!!!

The principle of action of the drug

The principle of action of the drug is due to its ability, as a gonadotropin-releasing hormone agonist, to suppress the function of gonadotropic hormones, in particular follicle-stimulating hormone and luteinizing hormone, which regulate the production of estrogen. Buserelin depot competitively binds to the receptors of the pituitary lobe, activating a short-term increase in the level of sex hormones, which is observed during the first 10 days of administration.

After such an outbreak, the receptors of the cells of the anterior pituitary gland, which produce gonadotropic hormones, completely lose sensitivity to the stimulating effects of the drug. As a result, the secretion of gonadotropic hormones decreases, and with continued use of Buserelin Depot, it is completely blocked.

As a result, on the 12th–14th day of taking the drug, there is a complete suppression of the synthesis of sex hormones in the ovary and a decrease in the concentration of estradiol in the blood to postmenopausal values.

Thus, Buserelin-depot suppresses the function of gonadotropic hormones, thereby stopping the production of estrogen. The use of the drug leads to a decrease or complete disappearance of the typical symptoms of endometriosis, since, thanks to its effect, the growth of the endometrium is dulled.

It should be noted that treatment with Buserelin does not cure endometriosis completely. The pathology may recur after 1–2 years. But similar relapses can also be observed during surgical removal of endometrioid heterotopias. Therefore, it is rational to use a complex of hormonal and surgical therapy.

Indications for use

The general indication for the use of Buserelin is pathologies of the reproductive system, dependent on hormones, which were caused by relative or absolute hyperestrogenism. This condition is marked by an increased level of estrogen, which causes hormonal imbalance and disrupts the functioning of many organs. These diseases are: uterine fibroids, infertility during the IVF procedure, endometriosis in the pre- and postoperative period to reduce recurrences, breast cancer, hormone-dependent prostate cancer, endometrial hyperplasia.

Modern methods of treating fibroids

Doctors at our clinics use an innovative method of treating fibroids – uterine artery embolization. The procedure is performed not by a gynecologist, but by an endovascular surgeon. He is a highly qualified specialist in the field of vascular surgery and radiology.

Embolization is not accompanied by pain and does not require anesthesia. The doctor punctures the right common femoral artery under local anesthesia. After this, a thin catheter is inserted into the vessel and passed into the uterine arteries. Then an embolization drug is injected through the catheter, which blocks the vessels feeding the fibroid. Microparticles of the drug are biologically inert and do not cause allergic reactions.

Reviews about the procedure are only positive. Immediately after embolization, menstrual bleeding is normalized, its duration and volume are reduced. After a few weeks or months, the symptoms of compression decrease and disappear. Within 6-8 months after the procedure, myomatous nodes and the overall size of the uterus decrease. Small myomatous formations disappear completely. They are replaced by scar tissue and never increase in size, while after taking buserelin, fibroids grow back.

During pregnancy

According to reviews and according to the instructions, the use of Buserelin during pregnancy and lactation is prohibited. This is due to the hormonal effect of the drug and the negative effect on fetal development. During breastfeeding, the medication passes into breast milk, so it can enter the newborn’s body and lead to negative consequences.

Indications

Buserelin-Depot is used for the following types of gynecological diseases:

endometriosis stages 1-2 as monotherapy;
endometriosis stages 3-4, as a method of preparation for surgery;
uterine leiomyoma;
hyperplastic processes of the endometrium with the risk of precancerous changes;
postoperative management of endometrioid disease and uterine fibroids, as prevention of relapse of the disease;
hormone-dependent diseases of the mammary glands (mastopathy);
IVF (the drug is used in the preparation for artificial insemination).

Properties of the drug

Buserelin Depot is a medicine created for the treatment of endocrine diseases in women and men. The basis of the synthetic drug is a substance similar to natural hormones produced by the hypothalamus. The medicine acts on the pituitary gland, increasing the concentration in the blood of the main reproductive hormones - FSH and LH. This effect on the endocrine background ensures a decrease in the concentration of estrogen and a decrease in the risk of growth of myomatous nodes.

The advantages of the drug include:

rapid therapeutic effect for uterine fibroids;
1 injection per month is enough to get a good result;
preservation of the main reproductive organ and reproductive function.

Buserelin Depot after intramuscular injection ensures a long-term supply of the drug to the blood and an effect on uterine fibroids for 4 weeks. Reviews from women show that course treatment helps to significantly reduce the size of leiomyoma and creates conditions for the dream of having a baby to come true.

It is important to listen to the doctor and do everything correctly in order to provide therapy for the muscle tumor and preserve the ability to conceive and bear a fetus.

Advantages of the medicine

The undoubted advantages of treating endometriosis with Buserelin-Depot are:

high efficiency, which is associated with a guaranteed decrease in the level of estrogen in a woman’s blood;
ease of use (monthly injection);
no effect on body weight;
no negative effect on metabolism;
no risk of thrombosis and vascular complications;
the woman will not have an increase in hormones with androgenic effects (no seborrhea, acne and hirsutism);
there is no dysfunction of the liver, kidneys or digestive organs.

In severe forms of endometriosis, the drug has a multifaceted positive effect, helping the doctor relieve the woman of many unpleasant symptoms of the disease.

Indications

Buserelin-Depot is used for the following types of gynecological diseases:

endometriosis stages 1-2 as monotherapy;
endometriosis stages 3-4, as a method of preparation for surgery;
uterine leiomyoma;
hyperplastic processes of the endometrium with the risk of precancerous changes;
postoperative management of endometrioid disease and uterine fibroids, as prevention of relapse of the disease;
IVF (the drug is used in the preparation for artificial insemination).

Buserelin: what types of drug are there?

The hormonal balance in the human body is controlled by the brain: a special gland (hypothalamus) produces special substances (releasing factors) that act on most of the endocrine glands. With endometriosis, it is necessary to take into account the influence of estrogens - the more there are, the more severe the symptoms and the greater the risk of spreading endometrioid disease. Buserelin is one of those drugs that can suppress hypothalamic releasing factors and create conditions for reducing the production of estrogen. Typically, doctors use the following drug options:

Buserelin-Depot;
Buserelin-Long;
Buserelin acetate in the form of a nasal spray;
Goserelin.

Any type of drug provides a lasting therapeutic effect, but reviews from doctors show that it is better to give preference to the original drug (Buserelin-Depot).

Side effects of taking the drug

Artificial menopause does not go unnoticed for a woman. All the characteristic symptoms of menopause occur - hot flashes followed by chills, sudden mood swings, irritability and even aggressiveness. Many patients complain of insomnia or increased sleepiness, deterioration of attention and memory. Intimate life suffers - vaginal dryness makes sexual intercourse unpleasant. Characterized by decreased libido, headaches and attacks of dizziness.

Bone demineralization is another unpleasant side effect of therapy. A sharp decrease in estrogen levels leads to the development of osteoporosis, which threatens bone fractures. During treatment, a decrease in bone mineral density by 6-8% is observed. This fact limits the duration of therapy to 6 months.

One of the side effects of treatment with Buserelin may be osteopenia (decreased bone mineral density), which over time turns into osteoporosis.

To improve the tolerability of GnRH agonists, add-back therapy, or cover therapy, has been developed. According to this scheme, Buserelin Long is prescribed together with estrogen-containing drugs. The dosage of estrogen in them is minimal and does not affect the course of endometriosis, but the woman’s condition improves. Menopausal hot flashes go away, libido is restored, and mood improves. But the main thing is that cover therapy reduces the risk of developing osteoporosis and allows a woman to complete the entire course of treatment without risk to health.

On a note
Sometimes ovarian cysts form in the first months of therapy. These are functional formations - they usually do not require treatment and go away on their own within 2-3 cycles.

It is also useful to read: How endometriosis affects a woman’s intimate life