Baklosan patient reviews, instructions for use and composition

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Baklosan tablets are a new generation of muscle relaxants that are used to relieve increased muscle tone and eliminate pain due to muscle spasms. The drug is recommended for the complex treatment of multiple sclerosis, pathologies of the musculoskeletal system, and cerebral stroke. The medicine helps eliminate cramps in muscle tissue, facilitate massage and physical therapy.

Contraindications for use

Taking Baklosan tablets is contraindicated in the presence of the following pathological or physiological conditions of the body:

• Hypersensitivity or individual intolerance to the active substance or auxiliary component of the drug.
• Epilepsy is a severe pathology of the central nervous system, which is characterized by the development of severe tonic-clonic seizures.
• Having a history of seizures.
• Psychosis is an acute disturbance of the functional activity of the cerebral cortex, accompanied by the development of hallucinations, motor and speech excitation, and the appearance of delusional thoughts.
• Parkinson's disease is a severe disorder in the transmission of nerve impulses between motor structures and centers of the brain and spinal cord.
• Acute or chronic renal failure, in which the excretion of metabolites and unchanged active substances from the body is sharply reduced.
• Pregnancy at any stage and breastfeeding (if it is necessary to use the drug while breastfeeding, the child is transferred to taking artificial adapted milk formulas for the period of using Baklosan tablets).

Baklosan tablets are used with caution for cerebrovascular insufficiency (reduced volume and intensity of blood circulation in the brain), for gastric or duodenal ulcers, in the elderly and in children under 12 years of age

pharmachologic effect

Baclofen is a derivative of gamma-aminobutyric acid. Instructions for use of Baklosan tablets indicate that they are powerful central muscle relaxants. During the action of the main substance, a muscle relaxant (relaxation of muscle mass) and antispastic (elimination of muscle spasm) action occurs, which is facilitated by the following effects:

1. Decreased excitability in hypersensitive nerve fibers passing through the brain and spinal cord. As a result, the feeling of excitability is dulled and unwanted muscle cramps are prevented.
2. Reducing existing tension in the fibers of the striated muscles.
3. Suppression of excessive activity in interneurons responsible for the timely delivery of impulses to afferent nerve cells.

Thanks to such pharmacological effects, the drug Baklosan eliminates the readiness of muscles for cramps, and accordingly, the severity of contractile tension in them is minimized. Due to timely relaxation in muscle fibers, joint movements increase. As for the neuromuscular transmission of impulses at these synapses, there is no effect on it.

After oral administration, Baklosan is absorbed through the blood; the required therapeutic concentration occurs in about half an hour. As for the maximum accumulation of the active component in the blood masses, it is observed after 3 hours. Baclofen is characterized by high bioavailability, its accumulation in the tissues of the central nervous system and unhindered penetration through the blood-brain barrier are noted.

Normal passage of the drug through the placental barrier was noted, with subsequent distribution in the body of the developing baby in utero. You need to understand that baclofen is produced in breast milk. The metabolic process takes place in the liver. The resulting metabolites, as well as the active component, are excreted unchanged by the body through urine through the kidneys.

Side effects

Taking Baklosan tablets may be accompanied by the development of negative reactions and side effects from various organs and systems, these include:

• Digestive system - nausea, vomiting, dry mouth, unstable stool (constipation or diarrhea).
• Cardiovascular system – arterial hypotension (decrease in systemic blood pressure).
• Central nervous system - increased fatigue, disturbances of consciousness in the form of confusion, apathy (lack of emotions and indifference to the outside world), depression (decreased mood), anxiety, ataxia (staggering gait) and hallucinations. Seizures of varying intensity may also often develop.
• Musculoskeletal system – myalgia (severe muscle pain), muscle weakness, tremor (hand trembling).
• Eyes – nystagmus and spasm of accommodation (visual impairment when trying to focus on near and distant objects).
• Urinary system - development of chronic renal failure with long-term use of the drug, dysuria (painful urination, which often manifests itself as a burning sensation), enuresis (bedwetting). Sometimes acute urinary retention may develop.

If any side effects develop, use of the drug must be discontinued.

special instructions

Baklosan can cause an increase in the effect of drugs that affect the functions of the central nervous system and blood pressure. As a result of combined use with antidepressants, a decrease in muscle tone may be observed.

Using the medication may cause hallucinations . Therapy using Baklosan tablets eliminates the use of alcohol, since the drug enhances its effect.

Patients with liver disease should periodically monitor the activity of markers of liver cell destruction. As a result of the action of Baklosan, psychomotor reactions slow down, so patients should avoid performing work associated with increased concentration.

Non-standard scope of application of Baklosan

Since 2008, studies have been conducted in France on the effectiveness of using the drug for the treatment of alcohol dependence. The result was positive: 80% of patients were able to get rid of their bad habit. Therefore, since 2019, the drug has been approved for use in the treatment of alcohol dependence.

Due to the wide range of diseases for which Baklosan has a therapeutic effect, it has become widely used among the population. In addition to helping with various diseases, Baklosan gives a feeling of relaxation and confusion.

The drug is popularly called a legal drug, and the number of people who use it unnecessarily is growing every day. Moreover, tablets intended for oral use are often inhaled in powder form to achieve a narcotic effect. Over time, the body gets used to the drug, so large doses, several times higher than the norm, become necessary for a state of euphoria.

To purchase Baklosan, no special permission from a doctor is required, so it is available for free sale in pharmacies. Anyone can take the drug, but its use in uncontrolled quantities leads to a condition similar to drug addiction.

Overdose cases

If the therapeutic dose determined by a specialist is not maintained, and the drug is taken uncontrolled and in large quantities, the development of muscle hypotension may occur. It is accompanied by depressed tone and strength in the striated muscles.

In case of an overdose, it is also possible that the functioning of the respiratory centers may deteriorate, which can lead to respiratory arrest. In extreme cases, coma develops. And even if a person receives emergency assistance, symptoms of respiratory depression and muscle hypotension appear over the course of several days.

A specific antidote to the drug has not been developed. In the case of an overdose, the person’s stomach is immediately washed, and depending on his general condition, symptomatic treatment is carried out.

Among the analogues of Baklosan, Lioresal stands out in the form of rectal suppositories, Baclofen.

Indications for prescribing the drug

When considering the question of why the drug Baklosan is prescribed, it is necessary to focus not only on the aspects of pharmacological effects on men with prostatitis, but also on the advisability of treating other forms of pathologies of various etiologies. The medicine Baklosan has the following indications for use:

• Increased muscle tone in various forms and stages of multiple sclerosis (in particular with sclerosis of prostate tissue);
• Tumors localized in the spinal column;
• Diseases of the spinal cord of an infectious nature;
• Syringomyelia;
• Motor neuron diseases;
• Spinal column injuries;
• Stroke;
• Cerebral palsy;
• Cerebrovascular pathologies in adult patients;
• Meningitis of various etiologies;
• Traumatic brain injuries;
• Alcoholism;
• Myelitis;
• Heart attack;
• Convulsive syndrome of unknown origin;
• Spasms in the muscle tissue or glandular organs, accompanied by unbearable pain.

Patient reviews

Victor. I have a first group disability. I have been suffering from muscle hypertonicity for about 15 years. Treatment with Baklosan helps to partially relax the muscles, flex and straighten the arms and legs. For me, using the drug is necessary.

Kirill. I take Baklosan as prescribed by a doctor after a traumatic brain injury received in an accident. During treatment, the prescribed dosage should be strictly observed. The medicine helped me, for which I am very grateful to the doctor.

Svetlana. The drug was prescribed for cerebral circulatory problems and lumbar arthrosis. I take one tablet twice a day. After seven days of use, no side effects are observed, and there is a noticeable improvement in the condition.

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Dosage violations and their consequences

Exceeding the recommended dosage may lead to a number of health problems.

Elderly people should be especially careful as their bodies will be more susceptible to side effects. Consequences of overdose:

• Nausea;
• Profuse vomiting;
• Diarrhea or constipation;
• Excessive fatigue;
• Dizziness;
• Reduced pressure;
• Urinary incontinence;
• Vision problems due to nerve dysfunction;
• Involuntary muscle contraction;
• Swelling of the body;
• Muscle pain;
• Unreasonable euphoria;
• Apathy, manifestations of depression;
• Gait disturbance;
• Dry mouth;
• Constant drowsiness;
• Loss of sensation;
• Numbness.

Long-term use of Baklosan, even if the dosage is strictly followed, can lead to impaired kidney function. Therefore, courses of taking the drug are usually short-term. It is also recommended to take pills only with a doctor's prescription.

Pharmacological properties of the drug

A persistent increase in the tone of skeletal muscles occurs due to the disinhibition of the segmental apparatus of the spinal cord observed in various pathological conditions, disturbances in the conduction of nerve impulses and an imbalance of signals conducted from the central nervous system to muscle fibers and in the opposite direction.

The therapeutic effect of Baclofen is based on its ability to change the body's stereotypical reaction to a stimulus, coordinated by the nervous system. Baclofen inhibits spinal cord reflexes - spinal, carried out with the help of striated muscles (stretch reflex, flexion, extensor, tendon, positional, rhythmic) and visceral, responsible for the functioning and operational state of internal organs and regulated by the efferent structures of the autonomic nervous system. This occurs due to the stimulation of presynaptic metabotropic GABA receptors, classified as class B. These cellular receptors are found in all parts of the nervous system, activate potassium ion channels that control many physiological functions of the cell, and prevent the release of amino acid neurotransmitters that facilitate the transfer of information between neurons and glands and muscle tissue.

The result of the influence is:

• muscle relaxant effect – reduces the sensitivity of neurotendon and muscle spindles and their aggressive reaction to changes in the length and force of contraction of fibers, relieves skeletal muscles from hypertonicity;
• antispastic effect – relieves spastic syndrome by suppressing mono and polysynaptic spinal reflexes and improving electrical transmission in the spinal cord;
• analgesic effect - reduces pain by activating specific opioid receptors, increasing the synthesis of neurotransmitters, endogenous opioid peptides, thereby reducing the body's pain sensitivity;
• antidepressant effect - fights excessive excitability of the subcortical parts of the brain, has a calming effect, suppresses fear, anxiety, and reduces the effects of stress. The effect is achieved due to the presence of the body's main inhibitory neurotransmitter, gamma-aminobutyric acid, which is responsible for the production and maintenance of the balance of hormones, neurotransmitters and other substances that provoke overexcitation.

Symptoms of an overdose of Baclosan

After entering the gastrointestinal tract, the drug is absorbed, and after 2.5-3 hours the concentration of the active substance, baclofen, reaches its maximum level in the blood. The medicine remains in the lymph for about 8 hours, so there is no need to take it earlier than after 7 hours.

About 30% of the active substance binds to blood proteins, the rest is almost completely processed by liver cells - hepatocytes and rushes to the diseased organ.

If the dose of the drug is too high, the body responds in the form of the following signs of intoxication:

Muscle hypotension. The disorder is manifested by symptoms: drooling, decreased muscle strength, decreased activity, lethargy. Confusion

In this state, a person is unable to concentrate attention on anything, and therefore, to make decisions.

As a result of prolonged exposure to Baklosan, the main signs of confusion appear:

• Changes in speech: it becomes confused. From the outside, it seems that a person takes a long time to find the right words, so he makes long forced pauses.
• Poor orientation in space and time.
• Inability to concentrate on completing a specific task. Loss of the essence of the issue being solved, unclear purpose of the actions being performed.
• Quick change of mood. The appearance of causeless anxiety, aggression, joy or depression.

It is important for parents of children to know about such side effects of the drug, since teenagers actively share knowledge about available narcotic substances. Aggression and rejection of parents are a reason for tightening control over the child’s social circle and actions

Respiratory failure is a pathology associated with gas exchange disorders in the lungs. As a rule, this condition is accompanied by a drop in the partial pressure necessary to saturate the blood with oxygen below 60 mmHg. Art.

For comparison, the normal partial pressure of oxygen for a young person is 95-100 mmHg. Art., and for an elderly person (over 70 years old) – about 70 mm Hg. Art. At the same time, the pressure of carbon dioxide, on the contrary, increases, reaching a level of 45 mm Hg. Art. (at a norm of 40 mm Hg). A drop in oxygen levels leads to increased blood circulation to compensate for the loss of oxygen from vital organs.

The first symptoms of respiratory failure are:

1. Heart rhythm disturbance.
2. Nausea.
3. Headache.
4. Sleep disturbances (desire to sleep during the day and insomnia at night).
5. Frequent breathing, shortness of breath.
6. Panic state of the patient.

If assistance is not provided in a timely manner, the most severe consequence of respiratory failure can be coma or death.

A coma occurs as a result of a severe overdose. This condition can develop from several hours to several days and is characterized by loss of consciousness, inhibition of the functioning of all vital systems of the body.

It is important to recognize a life-threatening condition

Precoma has the same symptoms as an overdose of Baclosan. This is confusion with changes in behavior and impaired psychomotor reactions, but reflexes are preserved.

• Coma at the 1st stage of development is characterized by stunning, inhibited reaction to stimuli, and the absence of a swallowing reflex.
• At stage 2 of development, a person does not control bowel movements and urination, the skin loses sensitivity, and a state of deep sleep occurs.
• At stage 3, consciousness, reaction to pain and light are absent, breathing, pressure, and body temperature decrease.
• At stage 4, it is necessary to use an artificial respiration apparatus, otherwise the patient will die.

If Baklosan poisoning occurs, it is necessary to call an ambulance and take all possible measures to preserve the person’s health.

Video: Baklosan.

Is Baklosan a drug?

You cannot take the drug for a long time, otherwise the drug is addictive, which is why many people recognize it as a narcotic drug. Those who stop using the drug abruptly actually experience the so-called “withdrawal syndrome” familiar to drug addicts. The patient feels depressed, depressed, apathetic towards everything, does not want to live, suicidal moods may appear, a state of anxiety up to attacks of uncontrollable fear.

You should stop taking the drug as gradually as you started. Abrupt withdrawal of the drug worsens the patient's quality of life. Pain returns, mobility of the spine and limbs decreases. It seems to the patient that the pain has intensified, although in fact it has remained at the same level.

People with an unstable mental state need to be especially careful, and if the symptoms worsen, they need the help of a narcologist and even sometimes a psychiatrist. You should not turn a blind eye to the patient’s depressive state, because it will not go away on its own and will only get worse. The sooner the patient contacts a specialist, the better.

How to get rid of addiction

The drug does not cause chemical addiction; it is predominantly psychological, and traditional drug treatment in this case is ineffective. The peculiarity of baklosan is that it is necessary to control its withdrawal, monitor the patient’s condition, gradually returning him to a full, healthy life. The Narconon program provides this effect.

The technique does not involve drug detoxification (this is important in the treatment of psychological addictions). The consequences of damage to the body are eliminated by taking vitamin-mineral complexes, niacin, and oil mixtures

They are supplemented by diet, running, and visiting the sauna. The physical and psychological consequences of intoxication during drug withdrawal are eliminated with the help of assistive procedures performed by specially trained staff.

Healthy communication skills are returned by sequentially going through the following stages:

• “Objective processes” - gaining a clear view of what is happening;
• “Overcoming ups and downs in life” - support aimed at avoiding temptations, harmful, old social circles;
• “Personal values” - liberation from the past and awareness of one’s own responsibility for actions;
• “Changing states in life” - developing the ability to creatively solve problems;
• “Life Skills” - obtaining tools for conscious and complete abstinence from drugs.

On average, the program lasts from 8 to 10 weeks. The result of its complete completion is cessation of drug use and preservation of the effect for life.

Consumer Reviews

A potent narcotic drug helps cope with serious pathological processes. If it is used correctly and all the doctor’s instructions are followed, the treatment generally takes place without unpleasant symptoms, as indicated by patient reviews.

Several years ago, my daughter was diagnosed with a neurological disease that resulted in disability. The doctor prescribes regular use of Baklosan, it helps us well, relieves spasms, which no drugs could cope with before.

Maria, 46 years old

While working, I sit at the computer for a long time, which causes terrible pain in my shoulder and neck areas. The neurologist recommended taking a course of treatment with Baklosan. In the first few days I felt like I was “weightless”, but over time I began to adapt. I concluded for myself that taking this medicine should be combined with massages or therapeutic exercises.

Evgeniy, 32 years old

For our family, Baklosan became a real salvation when my grandmother had a stroke.
The right side was seriously damaged, which is all we had to go through to eliminate its immobility! Muscle tension is now well relieved by this medicine, and painful spasms occur very rarely. Irina, 37 years old

Baklosan is a specific drug against prostatitis

Baklosan, according to patient reviews, can partially solve another significant problem - inflammation of the prostate gland in men

Doctors emphasize that the drug is used exclusively to eliminate symptoms, which, due to certain circumstances, the patient can tolerate with great difficulty

Baklosan (baclofen) is a muscle relaxant that can eliminate pinched pain. This means that the pharmacological product will not always relieve negative symptoms.

Baklosan, according to reviews from doctors, exhibits the highest degree of effectiveness in the treatment of prostatitis and other forms of prostate disease if pain occurs due to improper attachment of the pelvic muscles. This may be a consequence of surgical intervention in the tissues of the pelvic organs due to hidden and obvious injuries.

Certain sports and previous infections can also lead to similar phenomena.

Why is baclofen used in medicine?

The pharmacological activity of the drug is mainly manifested in its antispastic effect. Baclofen also works as an analgesic and muscle relaxant. It is bound to plasma protein by 30%, metabolized in the liver and excreted by the kidneys. Analogues of baklosan are Tizanil, Sirdalud, Mydocalm and other drugs of the same group.

Baclofen in different forms and doses is prescribed for:

• multiple sclerosis, stroke;
• tumors, injuries and infections of the spinal cord;
• cerebral palsy, meningitis;
• TBI and other diseases accompanied by spasticity of skeletal muscles.

Consequences of use and development of addiction

What is baclofen from the point of view of a narcologist? This is a drug that, when taken uncontrolled, has an effect similar to butyrate and MDMA. Knowing what baclosan is, drug addicts use it to enhance the effect of other dangerous drugs (marijuana, amphetamines), which provokes neuropsychic disorders.

The medicine causes strong psychological dependence due to withdrawal symptoms - loss of appetite, nighttime panic attacks, insomnia. The drug is easy to purchase at the pharmacy. It is accessible, and due to its low price and prevalence, it is becoming a drug popular among teenagers and marginalized people. Addicts taking baklosan drink it in tablets or inhale the powder of the drug through the nose, which leads to damage to the respiratory tract.

The physical harm that baclofen causes to the body and the consequences of its abuse are significant - this is both a threat to the patient’s mental state and a disruption of the body’s functioning. As noted in the dissertation by Candidate of Chemical Sciences O.A. Dukov, information about severe poisoning is increasingly appearing regarding the drug. The drug is also dangerous because it causes:

• asthenic condition, dizziness;
• muscle hypotonia, tremors of the arms and legs;
• headaches and cramps;
• constipation for up to a week, nausea;
• manic-depressive, obsessive-compulsive disorder, sociopathy;
• sudden death due to respiratory arrest.

Analogs and price

The choice of analogue is made by the attending physician, taking into account contraindications and the patient’s condition. Similar in composition and active component are Lioresal, Baclofen, Mydocalm, Tizanidine, Sirdalud, Tizanil.

You can purchase the medicine at the pharmacy with a doctor's prescription. The price of Baklosan 10 mg and 25 mg tablets is 270 rubles, Baklosan 50 mg costs from 520 rubles.

Excessive dosage

When taking baclofen, an overdose is expected. This is due to the loss of self-control when taking medication and the formation of psychological dependence.

Symptoms

Accidental or intentional excess of the drug dose is characterized by the following symptoms:

• slowing down of mental activity;
• confusion;
• lack of reflex muscle function (may last about 72 hours), likelihood of falls due to inability to maintain an upright position;
• dizziness followed by fainting;
• paleness of the skin;
• chills, fever, cold sweat;
• drop in blood pressure due to blockage of the pressor department;
• depression of respiratory function due to suppression of the activity of centers in the medulla oblongata;
• delirious or comatose states.

Taking baklosan regularly and for a long time, the consequences can be very disastrous. Muscular hypotension is fraught with immobility, as well as weakening of the respiratory muscles. When respiratory activity is suppressed, respiratory pathology (Cheyne-Stokes) is likely to develop.

Medical practice knows cases of death due to brain death. The lethal dose is individual for everyone.

Treatment of addiction to baclofen (baclosan)

Treatment of addiction to baklosan in a rehabilitation center gives drug addicts a chance to return to normal living conditions. Medical institutions accept patients in any condition of severity and try to provide assistance to everyone who applies for it. Patients undergo a detailed examination of the body. Only after this is a diagnosis made and complex recovery therapy prescribed. First of all, the drug addict’s body is cleansed of harmful and toxic substances. The patient then undergoes treatment and psychological rehabilitation. Drug addicts in the past strengthen their psyche and begin to control their behavior.

Baklosan tablets instructions for use

"Baklosan" is taken orally during meals. If you had to skip one dose of the drug, you do not need to take a double dose the next time.

Adults and children over 12 years of age are required to take 5 mg of medication three times a day. Over the course of several days, the dose of the drug must be increased to achieve a therapeutic effect. Typically this dose is 35-75 mg. The maximum amount of baclofenane should exceed 25 mg per day.

For older people, the dosage is the same as for adults, but increasing the daily dose of the active substance will require a longer period of time, as there is a possibility of side effects.

Children should begin treatment with a dose of 5 mg three times a day. The maximum amount of active substance depends on the age of the child:

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• from 3 to 6 years – 20-30 mg per day;
• from 6 to 10 years – 30-60 mg per day;
• from 10 to 12 years – 2.5 mg/kg body per day.

Release form

The drug is made in slightly convex, round tablets, painted white. The main active ingredient is baclofen, the concentration of which in 1 tablet is 25 or 10 mg. Auxiliary ingredients include gelatin, potato starch, lactose, ethylcellulose, magnesium stearate.

The medicine is packaged in plastic bottles of 50 pcs. One bottle is placed in a cardboard box for convenient storage and long-term use of the medicine.

Negative consequences

The medication is taken under the supervision of the attending physician.

Formation of habituation

Baclofen is addictive

Initially, the substance was synthesized in order to eliminate epileptic attacks and prevent them. Subsequently, the medicine was no longer used for prophylaxis. Because patients developed persistent addiction, which increased the risk of overdose.

Mechanism

After 5-7 days of systematic use of baclofen, dependence develops. This effect is due to the strong effect of the active substance on the central nervous system. The psychotropic properties of the drug cause a state of euphoria, increase motor activity, and eliminate feelings of anxiety and uncertainty.

A person experiences a surge of strength, the need for rest disappears, efficiency and an irresistible desire for communication increases. This effect lasts up to 10-12 hours.

However, after the drug is removed from the body, severe depression develops.

Possibility of physical dependence

The main physical effect is decreased muscle tone (muscle hypotonia). This is the cause of excess energy and euphoria. But taking excessive doses results in weakness, clumsiness of movements, and decreased reflexes.

However, chemical and physical dependence does not occur.

Possibility of psychological dependence

Not wanting to experience the usual feelings of anxiety and fear that return after the end of the drug effect, patients begin to take baclofen regularly.

When possible attempts to do this, a person experiences withdrawal syndrome, which is characterized by atony, convulsions, cramps, migraines, depression, and pain throughout the body. Therefore, doctors recommend a gradual reduction in dosage.

Drug addiction and alcoholism

Paradoxically, in some European countries this remedy is used in the treatment of drug and alcohol addicts.

On the one hand, the medication relieves withdrawal symptoms. However, quite often patients, after discharge from the hospital, continue to take the drug, but in tandem with hard drugs. By prolonging and enhancing the effect of drugs, this drug provokes severe poisoning with baklosan and the development of polydrug addiction.

Baklosan is incompatible with alcohol

Alcohol addicts do the same thing, combining alcohol with the drug. Which leads to alcohol intoxication. Because the medication is not compatible with alcohol. This is due to the fact that when combining these substances, a person may not feel intoxicated. But after the medicinal effect ceases, the reverse process occurs.

Combination with medications

When taking baclosan simultaneously with tricyclic antidepressants, muscle hypotension increases.

Concurrent use of antiparkinsonian medications increases the risk of developing hallucinatory manifestations and psychomotor overexcitation.

Effect of the drug

Baclosan is a muscle relaxant with analgesic and anti-inflammatory properties. The medicine reduces motor activity and muscle tone.

The active substance inhibits the excitability of the endings of sensory fibers and reduces the conduction of nerve impulses by neurons, which helps relieve tension in muscle tissue. The medicine does not affect the nerve transmission of impulses, so it is often used in the treatment of neurological disorders accompanied by muscle spasms. The drug also helps eliminate muscle pain and increase motor activity of joints.

After use, the active substance penetrates into the systemic bloodstream within 30 minutes. The maximum concentration is achieved three hours after taking the product. The breakdown of the drug occurs in the liver, the remains are excreted from the body by the kidneys.

Baclofen is able to cross the blood-brain barrier and accumulate in nerve fibers. Baclofen, crossing the placental barrier, accumulates in fetal tissues.

Side effects

The medicine Baklosan is potent, so the presence of side effects is not surprising. But in some cases they become serious and require special attention. You should definitely find out about such side effects before you start taking the drug.

Some patients, after starting to take the drug, may develop muscle soreness - so-called myalgia.

The most common side effects are weakness, sleep disturbances, and gait disturbances. Drowsiness, nightmares, asthenia, and tremors of the extremities were noted. Sometimes there is the appearance of sharp oscillatory eye movements, a depressive state develops or, on the contrary, a state of complete euphoria. The listed side effects are only a small part of them, which relate only to the nervous system.

There is a possibility of respiratory dysfunction: the appearance of shortness of breath, attacks of lack of air. In some cases, the cardiovascular system may suffer from hypotension. Vision is impaired and body temperature drops.

There is a high probability of problems with stool. Some patients experienced abnormalities such as diarrhea and constipation. In more rare cases, liver damage occurred, causing pain in the abdominal cavity. Nausea occurred and, less frequently, vomiting.

For men, there is a possibility of erectile dysfunction. In certain cases, enuresis and urine retention develop. In some cases, excess urine output was noted—that is, polyuria developed.

Special Recommendations

Taking the drug sometimes causes addiction, so many patients are interested in how to properly stop taking the drug after a course of therapeutic measures.

If addiction does occur, you should inform your doctor about this problem. Often, he prescribes a gradual reduction in the dosage of the drug, and subsequently a complete refusal of it. This measure is necessary, since if abruptly discontinued, the patient will experience serious withdrawal, which will lead to a general deterioration in health. There is a possibility that the state of the nervous system will be disrupted.

Using the drug for a hangover

Alcohol is a toxin that depresses the nerve system. The breakdown products of alcoholic beverages cause poor health. Ethanol is the main culprit in the occurrence of the post-taxation state.

The concepts of “hangover” and “abstinence” are often confused. With the first option, someone who has had too much in the evening will never think about “treating” with alcohol. Absistence – a craving for alcohol the morning after drinking strong liquids, means the first stage of alcohol dependence.

It is not recommended to take the drug during the period of morning sickness after drinking alcoholic beverages. Taking medication will not make you feel better, but will worsen your health.

Ethyl alcohol, after it gets inside, does not have time to leave the organ cells and blood by the morning. The use of the drug leads to a mixture of components. This can cause acute mental illness.

Consequences of taking Baklosan

Previously, Baclosan was used for the prevention and treatment of epilepsy.
But then it turned out that the drug was addictive, and they stopped using it. The drug demonstrates a strong psychotropic effect, eliminates anxiety, improves mood, even euphoria. The duration of sleep and rest decreases, physical activity increases. In this case, the ability to objectively evaluate is lost, and the desire for creativity arises.

As a result of drug withdrawal, depression develops. Complications after an overdose for a drug addict boil down to numerous mental disorders. Consequences:

• Sociopathy develops.
• Lost connection with reality.
• Manic-depressive psychosis occurs.
• Obsessive states appear.

Withdrawal from the drug causes a feeling of total devastation in the drug addict. It is so pronounced that patients resort to suicide.

Clinical picture of overdose

The lethal dose of baklosan is individual for each person and is directly dependent on the state of health and the duration of drug addiction. For example, in patients with endocrine diseases and liver pathologies, taking several tablets can provoke excess production of hormones, which is an extremely dangerous condition for human health.

If the drug addict has a history of stomach and duodenal ulcers, taking too many pills will cause painful abdominal cramps and heavy bleeding. Death will result from perforation of the ulcer.

Accidental or intentional overdose is characterized by the following symptoms:

• Slowing of mental activity, confusion. The person does not understand and is not aware of the essence of what is happening.
• Lack of muscle reflex. The drug addict is unable to remain in an upright position; falls, bruises, and head injuries are possible.
• Dizziness gives way to deep fainting.
• The skin is pale, chills, fever, and cold sweat appear.

Fatal outcome as a result of overdose occurs due to the development of central respiratory failure due to the anesthetic effect of baclosan. Insufficient ventilation of the lungs occurs against the background of a lack of molecular oxygen inside the bloodstream. It is replaced by carbon dioxide, intoxication with which provokes:

• increased heart rate;
• arterial hypotension;
• breathing disorders.

Low oxygen concentration accelerates blood circulation and promotes swelling of large and small vessels. The drug addict experiences shortness of breath and coughing when trying to inhale. A panic state develops. After a few minutes, the person falls into an unconscious state, followed by a coma. In the absence of medical intervention, swelling of the pulmonary parenchyma and brain occurs, which becomes the cause of death.

About the drug Baclosan

Baklosan is used to treat neurological diseases that occur with painful spasms of skeletal muscles and clonic convulsions. The drug relieves pain, reduces muscle tone and eliminates spasms. Indications for use:

1. post-stroke condition;
2. injuries, tumors and infectious diseases of the spine;
3. cerebral palsy;
4. meningitis;
5. multiple sclerosis;
6. osteochondrosis, arthritis and arthrosis;
7. relief from tetanus;
8. neoplasms in the brain.

The drug was created for the treatment and prevention of epileptic seizures.

Contraindications

Poisoning with Baklosan can occur even when taking a therapeutic dose of the drug if the patient has contraindications. In addition, there are a number of pathologies for which the use of this drug is prohibited. Contraindications:

• individual hypersensitivity;
• Parkinson's disease;
• disruption of the respiratory system;
• epileptic seizures;
• urogenital pathologies;
• mental disorders;
• convulsive syndrome;
• ulcerative pathologies of the stomach and duodenum;
• diseases of the liver and biliary tract.

The drug should not be taken during pregnancy and lactation. The exception is cases when the benefit to the mother outweighs the possible risk to the fetus. It is also not recommended to use it for sclerotic phenomena in blood vessels and cerebral circulatory insufficiency.

Side effects when taking Baclosan

The negative consequences of drug treatment are more typical for older people. In addition, they are often observed when the therapeutic dosage of Baklosan is independently exceeded. Side effects:

1. visual and auditory hallucinations, anxiety, depression;
2. decreased blood pressure, deterioration of cardiovascular system functions;
3. diplopia, trembling of the eyeballs;
4. disruption of the gastrointestinal tract: decreased peristalsis, bloating, nausea, vomiting, heartburn and belching;
5. drowsiness, apathy, emotional lability, migraine;
6. loss of appetite, weight loss.

Overdose

Exceeding recommended doses is manifested by the following symptoms:

• coma;
• muscle hypotonicity;
• confusion;
• depression of the respiratory center.

Taking into account the fact that there is no specific antidote therapy, it is recommended to drink plenty of fluids and diuretics. Artificial ventilation is performed if respiratory depression is diagnosed.

Long-term use of this drug can cause problems in the functioning of the kidneys.

Precautionary measures

According to the RLS (medicine register), to reduce the likelihood of side effects, patients with liver disease and diabetes should undergo regular examinations of the condition of liver tissue and blood glucose levels.

The drug should be discontinued gradually so as not to cause a negative reaction in the body. If symptoms such as severe chest pain, choking, disorientation, hallucinations, convulsions, severe visual impairment, or vomiting occur, call an ambulance immediately.

And it is also not recommended to use Baklosan before driving vehicles and for people who need to be concentrated at work.

In some cases, Baclosan is prescribed in combination with other medications. These are usually medications designed to treat the nervous system, high blood pressure, and gout symptoms. Taking Baklosan with strong antidepressants can cause a pronounced decrease in muscle tone. Drugs to reduce Parkinson's symptoms may cause confusion and hallucinations if taken with Baclosan.

The nuances of use for pregnant women, during lactation, children and the elderly

For patients under 3 years of age, and sometimes 12 years of age or after 65 years of age, tablets are prescribed if they are absolutely necessary, and the condition of the body is monitored when taking it. Pregnant and lactating women are prohibited from drinking Baklosan. Possible pathologies of fetal development, premature birth or complications of the birth process.

The drug may reduce the reaction rate, so it is better to refrain from driving and potentially dangerous actions.

CleverMindRu

Hi all! A couple of days ago, the editor of our VK group, Dmitry Bobrov, received a message from a person who had been using Baclofen (medicine, “pharmacy drug”) for a long time. I don’t presume to judge the complete reliability; after all, the person relied on his own experience, and not on evidence and research.

The project is by no means a “moralphage”, we can safely write about the benefits of certain drugs, but VERY many people underestimate the danger of what is in pharmacies, they say, “this is a pharmacy, everything there is useful for good health!” First of all, this review is specifically for those who think so, even unconsciously. “First of all, this is a medicine, but at the same time it is a classic drug that causes severe dependence and a very unpleasant withdrawal syndrome. Naturally, to obtain a narcotic effect, you need to take more than the therapeutic dose, but not by much; there are cases when a person, even taking 25 mg per day, enjoys it and faces unpleasant consequences at the end of treatment.

It gained particular popularity after the ban on the free sale of codeine-containing drugs; many lovers of pharmaceutical drugs switched to it. The vast majority of buyers purchase it not for medical reasons, but for recreational use. Formally, this is a prescription drug, but in practice it is sold to everyone; they are either not interested in having a prescription at all, or are content with the answer “I forgot at home.” Of course, a lot depends on the individual characteristics of the person, but on average, beginner baclonauts (drug addicts addicted to baclosan/baclofen ) take 75-100 mg, which is enough at first to feel its full effect. For some, it does not cause any positive effects, only side effects in the form of vomiting, loss of coordination, etc. And the main effects are as follows: strong empathy, hyper sociability, foolishness, excellent mood, a feeling of happiness, the disappearance of all sorts of fears and complexes, increased activity, interest in the world around us, 4-5 hours of sleep begin to be enough.

Naturally, there are also unpleasant side effects, but they are usually simply not noticed at the first stage. Reminds me of ecstasy lite. Thus, if a person likes the drug, as a rule, he begins to take it every day, in full confidence that he can quit at any time and nothing bad will happen. Sooner or later, tolerance develops, the number of side effects increases, and dosages for some consumers reach up to 400 mg per day.

Gradually, instead of feeling happy, depression appears even while taking it. Plus, when taken for a long time, it has an extremely negative effect on the condition of the kidneys and pancreas; at best, swelling and pain in the side appear, and often it ends up in the hospital. Deaths have also been recorded. Naturally, an awareness of one’s plight arises and a decision is made to quit and never touch these pills again. And then a severe withdrawal syndrome arises - suicidal thoughts, insomnia, constant anxiety, inability to communicate with people without fear, paranoid thoughts. All those psychological problems that were previously perfectly masked with the help of pills appear, amplified significantly.

There is also a risk of developing multiple organ failure and death if the drug is abruptly discontinued if it has been taken for a long time in doses above 150 mg. The acute phase of “withdrawal syndrome” usually lasts about two weeks (if you do not take sleeping pills at a minimum, there is a high risk of developing acute psychosis or a suicide attempt), then follows a very long period of depression, weakness, and constant internal tension. Moreover, neither antidepressants nor any other medications (except for other pharmaceutical drugs with a similar mechanism of action), as a rule, practically do not help. It usually ends with the quitter getting tired of enduring all this and going to the pharmacy for a new can, and everything repeats.

After several years, baklosan generally ceases to have positive effects, but there are often cases when one has to take it anyway in order to somehow survive, because without it a person can only lie in bed in a semi-vegetable state, it is impossible to even watch a movie, focus on the story. And this is such a terrifying state, reminiscent of insanity, that no matter what, there is an irresistible desire to get out of it. The majority of consumers still manage to quit, and even recover completely mentally and physically (if they took it for no more than two months, and in a dosage not exceeding 100 mg), but if the period is longer, a year or two, and the dosage was overestimated, negative consequences remain, but not so serious as to significantly reduce the quality of life. But for those who are at risk, people who initially have a number of psychological problems and injuries, distinguished by specific cognitive characteristics of the brain, it is extremely difficult to stop; the drug affects them in such a way that when they start using it, they do not even understand that those magical changes personal qualities and attitude towards the world around them are caused by the fact that they eat 3-4 small tablets daily.

A person simply becomes different, anxiety, fears, complexes, isolation and everything that previously prevented him from being happy disappear. And a feeling arises like, yes, here I am, the real one, finally it happened. Naturally, if in order to obtain similar effects it would be necessary to inject heroin, for example, it is possible that the understanding that this is a drug, from which it is much more difficult for the group described above to come off than from opiates, would still have appeared earlier. This situation is caused by the fact that 15-20% of those who decided to try it, most likely initially, from childhood, have problems with the normal functioning of the GABA neurotransmission, dopaminergic and glutamatergic systems. Therefore, they take it not for the sake of a buzz, but for the sake of adaptation in society, getting rid of the constant feeling of “misunderstanding” and loneliness, in order to receive joy from communication, experience vivid feelings and emotions and not be afraid to express them, not be ashamed of oneself and be sincere. And even having mentally understood that this is a very dangerous and harmful substance and after a month having decided to quit it, they go to the pharmacy again after one or two weeks, a simply uncontrollable desire arises. Because in a sober state, life already seems so gray and joyless; it is impossible to communicate with friends who appeared during the period of use; feelings and emotions disappear almost completely.

A person again wants to get into another world, become “himself”, and not experience constant internal tension. Then all this is repeated many times, first with a sincere desire to stop, then a period of sobriety, and again a breakdown. Dosages increase, the effect gradually fades away, no matter how much you take, depression appears while taking it, mixes with other surfactants and alcohol. Often, realizing that the situation is critical, the addict simply replaces it with another pharmaceutical drug, or begins drinking alcohol daily, sometimes in very large quantities. So, if a person does not quit on the first, or at most on the second attempt, he ends up in a vicious circle, irreversible damage to the most important brain systems occurs, despite the fact that not everything was in order with them in the first place. That is, even with maximum effort and quitting, it will probably never be able to recover, or (if the period of use is no more than two years approximately) it will take many years, perhaps decades.

It is surprising that despite the huge amount of information on the Internet about its powerful addictive potential, about numerous cases of ending up in intensive care and being in a two-three-day coma (including among schoolchildren), that the majority of those who buy baklosan in a pharmacy use it's like a drug - he's still not on the PKU. Those who decided to try it out of nothing to do, out of interest, to people who believe that it is not a drug, but just pharmacy nonsense, would simply not sell it. And to simulate diseases for which baclosan is indicated, firstly, is difficult, and secondly, those “interested” would most likely be lazy. I believe that it is necessary to put this drug on PCU, this will avoid deaths as a result of either an overdose or suicide (most often during withdrawal, but sometimes while under its influence, people have committed suicide).

On one forum, a doctor talked about a patient who, after a few years, reached the point where he could not work or think. They treated him long and hard (in the clinic), also for several years. Upon discharge, he hanged himself almost immediately. You also often see messages from addicts like this:

“THE BUCKLE IS FULL OF FUCK, WHICH CANNOT BE CONTROLLED, WHICH MAKES THE CAP LEAKING, IF YOU JOIN IT IN THE FINALE: YOU WILL END UP IN A MENTAL HOSPITAL, DROOLING.., WITH ORGANIC BRAIN DAMAGE AND A SMASHED FUCKING NERVOUS SYSTEM HIM!!! !!”

Moreover, the irony of fate is that something like this is written in a state of drug intoxication; a sober person addicted to baklosan cannot and does not want to write anything at all. Therefore, it is difficult to know how large the number of people facing this problem is. Even in a specialized forum dedicated to psychiatry and addiction, someone who stops taking baklosan has to use it again.”

Overdose and intoxication of the body

Clinical manifestations of overdose and poisoning of the body with Baklosan are similar to those during intoxication with alcohol, synthetic drugs, barbiturates, antidepressants and other centrally acting drugs. In the practice of narcologists, cases of overdose of this muscle relaxant are not uncommon.

• lack of any connection with reality
• acute disturbances in the functioning of the heart and blood vessels
• depression of the respiratory center
• renal and liver failure

Regular consumption of Baklosan intranasally or orally in increased dosages for several weeks inevitably leads to the death of the drug addict. In case of intoxication with a muscle relaxant, it is important to provide assistance immediately. The following algorithm of actions is recommended:

• Calling "emergency".
• Ensuring air flow.
• Drink plenty of fluids.
• Gastric lavage.
• Resuscitation measures in the absence of signs of life - pulse and breathing.

Baklosan has no antidotes. After the victim is admitted to the toxicology department, the doctors’ actions are aimed at relieving the symptoms of intoxication and eliminating its likely consequences.

There is information that adult drug addicts have a chance of surviving after taking Baklosan in a dosage of up to 1125 mg. A dose of 1250-2500 mg of muscle relaxant is lethal.

Interaction with other drugs

Baclofen was originally created as a treatment for epileptic disease. The substance was first synthesized by the large Swiss company Ciba-Geigy in 1962 by the famous pharmaceutical chemist Heinrich Keberle. Despite the fact that the drug did not succeed in treating epilepsy, it had a positive effect on the condition of patients who previously had:

• Stroke.
• Muscle spasms.
• Traumatic brain injuries.

The synthesized drug was initially intended to be used only orally, but the intrathecal method made it possible to achieve more effective treatment, without the side effects that could occur with the usual swallowing of tablets. Currently, Baclofen is used to treat a number of diseases.

Composition and properties

The composition of Baklosan is not overloaded with unnecessary components. Small round tablets contain:

• 10 or 25 mg of active ingredient - baclofen (ppm);
• lactose, gelatin, starch, E572, talc, ethylcellulose - for better digestibility.

The drug is packaged in jars of 50 tablets.

Being a muscle relaxant, the drug acts on GABA B receptors, which are responsible for the reactions of the nervous system. As a result of suppression of the activity of interneurons, the transmission of nerve impulses is inhibited, which leads to a decrease in the tension of the nerve receptors responsible for the contraction and stretching of skeletal muscles. It is important to note that Baklosan does not directly affect processes in neuromuscular synapses.

As a result of the use of the medication, uncontrolled spasms in skeletal muscles, which often occur in neurological diseases, occur. Thanks to complete relaxation of the body, it becomes easier to carry out massage, exercise and manual therapy.

Non-medical use

Non-medical use of Baklosan in a dosage of 50-150 mg (the maximum recommended therapeutic dose per day is 30-100 mg) gives a pronounced antidepressant effect, against which the mood improves, complexes go away, and the level of anxiety decreases. In most cases, severe drowsiness is noted.

The listed effects of taking Baklosan, based on unusual experiences after the influence of psychoactive substances, are included in the definition of “psychedelic state” or the slang word “trip”. This condition lasts for a limited time - after about 10-14 hours, the narcotic effect of Baklosan wears off, severe depression sets in, and the need arises to continue taking the drug.

We suggest you read: Reasons why alcohol is not broken down in the body

When the dose of 150 mg is exceeded, the opposite effect is sometimes observed - instead of euphoria, a person experiences severe aggression and emotional stress. This condition, according to narcologists, develops against the background of inhibition of dopamine receptors. The combination of Baklosan with other drugs or alcoholic beverages often results in acute intoxication, coma and death of the addict.

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We will help motivate a person so that he has a desire to get rid of addiction. We will give recommendations on how to communicate with a drug addict.

Many pharmacological drugs with narcotic effects are prohibited from free sale by regulatory authorities. There is a high probability that this will soon affect baklosan, a drug used in the treatment of cerebral palsy . Drug addicts use the drug for its euphoric effect in combination with other toxic compounds. An overdose of baclosan is often diagnosed in patients in intensive care units. The absence of a comprehensive antidote significantly increases the possibility of death.

First aid for overdose

Immediately after the first signs of poisoning appear, you must call an ambulance. The fact is that a complex antidote for removing baclosan from the body has not yet been synthesized . Therefore, comprehensive measures are taken to prevent dangerous symptoms of overdose. While waiting for the doctor to arrive, first aid should be provided to the drug addict:

1. Lay down, cover, calm down. If a person is unconscious, he needs to be turned on his side - this way he will not choke on vomit.
2. Clear your stomach. It is necessary to dilute potassium permanganate in a liter of warm water until a light pink color appears. Give the victim a drink and induce vomiting until clear liquid leaves the stomach .
3. Prepare strong sweet tea. The tannins and tannins contained in the drink will bind unabsorbed baclosan.

Any adsorbents or enterosorbents absorb the active substance of the tablets well. You can use several tablets of activated carbon as an antidote.

In case of overdose, a person must be hospitalized for further treatment. Complex detoxification therapy is carried out in a hospital setting. If necessary, the person is connected to a ventilator.

Baklosan (Baclofen) is a centrally acting muscle relaxant aimed at eliminating muscle spasms in pathologies of the central nervous system and dysfunction of the musculoskeletal system. An overdose of Baklosan occurs due to the fact that the patient neglects the doctor’s recommendations, independently increases the dosage, or prescribes the drug himself.

The result of such actions is the development of drug addiction or severe overdose, sometimes with irreversible consequences.

Analogs

As an alternative to Baclosan, you can take other medications whose active ingredient is baclofen. And also the drug can be replaced with centrally acting muscle relaxants. The most popular analogue of Baklosan is Baclofen from the Vidal company. But also popular:

• Mydocalm produced in Hungary. It is produced in tablets or ampoules. The price is 400 rubles per palette.
• Tizanidine , which is manufactured in Israel, costs no more than 200 rubles.
• Lioresal - Swiss-made rectal ampoules will cost from 1.7 to 2.4 thousand rubles.
• Sirdalud is also produced in Switzerland and costs about 340 rubles.
• Tizanil is an Indian drug that costs about 220 rubles.

You should not select an analogue yourself. It would be safer for your health to consult your doctor.