Fluconazole instructions for use for thrush, for the treatment of women and men

pharmachologic effect

The abstract contains information that the drug acts as an antifungal agent, specifically inhibiting the synthesis of fungal sterols . Belongs to the class of triazole compounds .

There is a specific effect on fungal enzymes that depend on cytochrome P450 . The active substance demonstrates activity against a variety of strains of Candida spp. (including effective against visceral candidiasis), Cryptococcus neoformans (including effective against intracranial infections), Trichophytum spp, Microsporum spp. The drug is also active against microorganisms that are causative agents of endemic mycoses: Coccidioides immitis, Hystoplasma capsulatum, Blastomyces dermatitidis.

The drug stops the conversion of fungal cells into lanosterol into ergosterol .
Under its influence, the permeability of the cell membrane increases, the process of its growth and replication is inhibited. It is highly selective for cytochrome P450 of fungi, but in the human body it almost does not inhibit these enzymes. Does not demonstrate antiandrogenic activity. https://youtu.be///www.youtube.com/watch?v=H2QSgQZo1No&t=153s

Pharmacokinetics and pharmacodynamics

Wikipedia indicates that after oral administration, the drug is actively absorbed into the human gastrointestinal tract. In plasma, the concentration of the active substance is more than 90% of the level that is observed if intravenous administration is practiced. The absorption of the substance is not affected by food intake, so it does not matter how you take it, before or after meals. After taking the medicine orally, the highest concentration in the blood occurs after 0.5–1.5 hours. The half-life from the blood is 30 hours. That is, you can take the product once a day. For vaginal candidiasis, a single dose of the drug is sufficient, for which one tablet or another form of the drug is used.

11–12% of the active substance binds to blood plasma proteins. When the drug begins to work depends on the treatment regimen. If you take the medicine once daily, then a stable concentration of the active component in the human blood is observed on the fourth or fifth day (in 90% of people). If on the first day of treatment the patient is given a double daily dose, then this effect is observed already on the second day of treatment.

Penetrates into all fluids in the body. It is excreted from the body through the kidneys, approximately 80% is excreted unchanged.

Indications for use

The following indications for use of the drug are determined:

infectious diseases caused by candida (disseminated candidiasis, generalized candidiasis, other forms of invasive candidiasis;
candidiasis of the mucous membranes (including the pharynx, oral cavity, esophagus);
candiduria;
chronic atrophic and mucocutaneous candidiasis of the oral cavity (develops in people with dentures);
non-invasive bronchopulmonary infections;
genital candidiasis (vaginal candidiasis in acute form and with relapses);
prevention of recurrent manifestations of vaginal candidiasis (if the disease develops three times a year), candidal balanitis ;
cryptococcal infection, cryptococcal meningitis;
onychomycosis;
dermatomycosis (including mycoses of the body, feet, groin area);
pityriasis versicolor;
endemic mycoses deep;
prevention of the development of fungal infections in people who have undergone cytostatic or radiation therapy.

Contraindications

There are the following contraindications for the use of this medicine:

manifestation of high sensitivity to fluconazole or to azole compounds, which are similar in chemical structure to fluconazole;
concurrent use of terfenadine if the patient receives a dose of Fluconazole 400 mg per day or more;
concomitant use of astemizole or any other drugs that increase the QT interval;
age up to 4 years.

It should be taken with caution in case of liver failure, also kidney failure, when a rash appears in people suffering from a superficial fungal infection, in potentially pro-arrhythmogenic conditions in people with risk factors (organic heart disease, taking medications that provoke the development of arrhythmia , electrolyte imbalance). How to take Fluconazole in this case, you should definitely ask a specialist.

In children

They try not to prescribe fluconazole for thrush to children under 4 years of age, but if other antifungal drugs do not help, it can even be prescribed to infants. The drug is taken once at a rate of 1-3 mg/kg body weight. For oral candidiasis, powder is poured out of the capsule, a solution is prepared from it, and the oral cavity is wiped with tampons soaked in it.

For severe candidiasis of the skin and mucous membranes, a course of treatment is carried out for a period of 3 to 5 days. If the child cannot take tablets and capsules, the doctor will prescribe rectal suppositories or intravenous administration of the medication. It is prescribed in the same doses as for tablets (capsules).

Instructions for use of Fluconazole (Method and dosage)

The drug is prescribed for oral administration (Fluconazole Stada capsules, Fluconazole Teva, tablets) or for intravenous administration. There are also other forms of medication, the active ingredient of which is fluconazole - suppositories, ointment.

The solution is infused at a rate not exceeding 10 ml per minute.

Fluconazole tablets, instructions for use

The dosage of the drug depends on the disease and its severity.

Patients with disseminated candidiasis and candidemia are prescribed 400 mg on the first day, then the dose should be reduced to 200 mg. For the treatment of generalized candidiasis, are advised to take 6–12 mg per 1 kg of weight per day.

For patients with oropharyngeal candidiasis , 50 mg to 100 mg of Fluconazole is indicated once a day, the treatment period is 1-2 weeks.

People suffering from atrophic candidiasis of the oral mucosa are advised to take 50 mg once a day. Treatment is combined with the use of local products for the treatment of prostheses. When treating other candidiasis infections of the mucous membranes, 50–100 mg per day is prescribed, the period of therapy is from 14 to 30 days.

In order to prevent the development of relapses of oropharyngeal candidiasis in people with AIDS , 150 mg once a week is indicated. If mucosal candidiasis develops in children, the dose should be taken at the rate of 3 mg of drugs per 1 kg of weight per day. On the first day, you can give your child a double dose.

Patients with cryptococcal infections and cryptococcal meningitis are usually prescribed 200–400 mg of drugs once a day. On the first day, 400 mg of the drug is indicated. The duration of treatment can be from 6 to 8 weeks. Children are prescribed a dose of 6–12 mg per 1 kg of weight per day.

People suffering from infectious skin diseases are recommended to prescribe 150 mg once a week or drink 50 mg of the drug once a day. Treatment should be continued for 2-4 weeks. For men and women with mycosis of the feet , longer therapy is sometimes required - up to 6 weeks.

Patients with pityriasis versicolor are recommended to take 300 mg once a week, the treatment period is 2 weeks. Depending on the intensity of your symptoms, your doctor may prescribe another dose of Fluconazole in the third week. It is possible to use another treatment regimen - 50 mg 1 time per day, the treatment period is two to four weeks.

Patients with onychomycosis are prescribed 150 mg once a week. Therapy should continue until a healthy nail grows in place of the diseased nail.

People suffering from deep endemic mycosis sometimes undergo a long course of treatment with the drug, which can last up to two years. The dose per day is 200–400 mg.

Instructions for the use of fluconazole for thrush stipulate that for vaginal candidiasis, a single dose of the drug is taken, its dose is 150 mg.

As a rule, Fluconazole for thrush is effective after a single dose. But your doctor will tell you more about how to take Fluconazole for thrush after an individual consultation. Before determining how to take any medicine for thrush if you have thrush, the specialist takes into account the causes of the disease and the individual characteristics of its course. For chronic thrush, Fluconazole Teva or other types of the drug are prescribed to prevent relapses at a dose of 150 mg once a month. The product should be used for 4-12 months. For the purpose of prevention, capsules are prescribed in a dose of 50–400 mg once a day, depending on how high the risk of the disease is. For children with thrush, Fluconazole tablets are prescribed at a dose of 3–12 mg of medication per 1 kg of weight per day. How much to drink depends on the severity of the infection.

For balanitis, the treatment regimen for men is as follows: the drug should be taken in a dose of 150 mg once.

Some patients are interested in whether it is possible to take pills or capsules during menstruation. According to experts, you can take Fluconazole at any time, regardless of your monthly cycle. How long it takes for the medicine to help depends on the intensity of the symptoms of the disease.

Possible adverse reactions

Fluconazole helps to quickly get rid of thrush. But taking it may be accompanied by adverse reactions. They occur rarely and, as a rule, with:

exceeding daily dosages;
long-term use;
individual intolerance to the drug.

The most common adverse reactions observed in patients are:

allergic reactions (manifested by swelling of the face, itching, rash);
dizziness;
nausea (sometimes vomiting);
headache;
bowel disorders.

After treatment, it is recommended to abstain from sexual intercourse for 4-7 days. If this is not possible, the use of local contraceptives is required.

Interaction

Before starting treatment, it is important to know not only what Fluconazole in tablets and other forms helps with, but also about the interaction of drugs with other drugs.

When taking Warfarin , the prothrombin time of fluconazole becomes longer.

With simultaneous administration of hypoglycemic oral agents belonging to the group of sulfonylurea derivatives, the half-life of Fluconazole increases. As a result, there is a possibility of hypoglycemia.

With simultaneous administration of Phenytoin, a clinically significant increase in the concentration of phenytoin is observed.

With simultaneous repeated use of hydrochlorothiazide, an increase in the concentration of fluconazole in the blood is observed. There is no need to change the dosage.

With simultaneous treatment with Rifampicin, AUC decreases by 25%. The half-life is also reduced by 20%. In some cases, the doctor decides to increase its dose.

When treating with Fluconazole, monitoring the concentration of cyclosporine in the blood is recommended.

If the patient is simultaneously receiving high doses of Theophylline, it is important to consider the possibility of Theophylline overdose.

It is contraindicated to take a dose of more than 400 mg per day in combination with Terfenadine.

When taking Cisapride simultaneously, negative side effects from blood vessels and the heart may occur, in particular, paroxysms of ventricular tachycardia .

If Fluconazole and Zidovudine , the patient should be monitored by a doctor, as the side effects of Zidovudine may increase.

If treatment with Astemizole , Cisapride , Tacrolimus , Rifabutin or any other drug that is metabolized by the cytochrome P450 system is simultaneously prescribed, the concentration of these drugs in the blood may increase.

The absorption of Fluconazole is not affected by simultaneous administration of Cimetidine or antacids.

Additional recommendations for treating thrush

Despite the fact that Fluconazole effectively fights fungal infections, you must adhere to a certain diet when taking it. You must refrain from consuming sugar and yeast for the entire treatment period. It is also not recommended to drink alcohol, soda and coffee. They “feed” the fungi, which leads to a decrease in the therapeutic effect of treatment.

In isolated cases, malfunctions of the liver and exacerbation of chronic liver pathologies may occur.

When taking Fluconazole, patients should focus on proper nutrition. Allowed to eat:

porridge with water;
soups prepared with fish or meat broth;
vegetables;
boiled meat;
seafood.

From drinks you can drink weak unsweetened tea, compotes, juices. But you should abstain from fruits or reduce their consumption to a minimum, since they also contain a lot of sugar.

special instructions

If liver dysfunction is observed during treatment, constant monitoring by a physician is important. If signs of liver damage are observed, the medication should be discontinued.

When using the medicine topically for men and women, it should be taken into account that people with AIDS are more likely to develop a variety of skin reactions.

It is necessary to take into account not only how long it takes for Fluconazole to act, but also the fact that if treatment is stopped prematurely, relapses may develop. Therefore, it is important to completely complete the prescribed treatment regimen. It is important to take this into account when using Fluconazole for nail fungus, since reviews for nail fungus indicate that if treatment is stopped prematurely, a relapse of the disease may occur.

Many patients have a question about whether Fluconazole is an antibiotic or not? Please note that this is an antifungal agent, not an antibiotic.

Whether men can take this drug depends on the diagnosis. Fluconazole for men is prescribed for fungal infections; it must be taken exactly as prescribed.

Briefly about thrush

Thrush (also known as candidiasis) is a fungal infection that affects the genitals. It is most often diagnosed in women, but can also occur in men. The main reason for the development of the disease is a violation of the microflora of the vagina or intestines. This can be preceded by various conditions:

stress;
taking antibiotics;
bad habits;
poor nutrition;
sexually transmitted infections;
chronic inflammatory diseases of the pelvic organs.

The fungus is resistant to external conditions and quickly adapts, so it can be easily transmitted from one person to another. Household transmission of infection rarely occurs. This is most often observed during unprotected sexual intercourse. Therefore, if a woman has been diagnosed with thrush, both partners must undergo treatment.

Main symptoms of candidiasis:

itching, burning;
unpleasant sour smell;
curd-like copious discharge;
swelling of the labia;
pain when urinating.

In men, thrush can provoke the formation of painful erosions on the penis, redness, and gray-white plaques.

Fluconazole analogs

Level 4 ATC code matches:
Medoflucon

Vfend

Itracon

Mikosist

Irunin

Mikomax

Orungal

Mycoflucan

Sporagal

Orungamin

Flucostat

Difluzol

Rumicosis

Futsis

Vero-Fluconazole

Kandizol

Kanditral

Itraconazole

Diflazon

Fluconazole analogues are products with a similar active ingredient. The price of analogues depends on the manufacturer and the form of release of the drug. There are a number of analogues of this drug: Diflazon , Diflucan , Vero-Fluconazole , Mikomax , Flucostat , Fluconazole Teva , Fluconazole Stada , etc.

Which is better: Fluconazole or Diflucan?

Often patients compare two drugs with antifungal action - Fluconazole and Diflucan . What is the difference between these medicines? Both drugs are based on the active substance fluconazole. Diflucan is available in tablets of 50 mg, 100 mg, 150 mg, and other forms. But the price of Diflucan is much higher.

Flucostat or Fluconazole - which is better?

Speaking about how Flucostat from Fluconazole, it should be noted that both drugs contain the same active substance. Flucostat is a more expensive medicine. What is the difference between these medications, and which one is best prescribed in a particular case, is determined by a specialist. As a rule, Fluconazole is more often prescribed when prophylaxis is necessary for cancer patients after radiation and chemotherapy.

Fluconazole or Nystatin - which is better?

Nystatin is an antifungal drug, an antibiotic, active against candida . Under the influence of Nystatin, the permeability of the membrane of fungal cells is disrupted, which contributes to disruption of their growth and reproduction. Which drug is preferred in a particular case depends on the diagnosis and the doctor’s prescription.

What else do you need to know?

Treatment with Fluconazole leads to the fact that the disease goes away within two or three days after taking the drug. However, to confirm the result, the doctor will prescribe a microflora test. This is the only way to be sure of a complete cure for Candida.

If Fluconazole is prescribed for thrush, the price of the drug is affordable for everyone. The cost of one capsule is from 15 rubles.

The active substance is also included in other antifungal drugs. The analogues are as follows:

Diflucan;
Mycoflucan;
Mycomax;
Flucostat;
Diflazon and others.

It is worth noting that the cost of analogues is much higher (more than 100 rubles per tablet). The minimum price for the domestic drug Fluconazole.

Video about the drug

https://youtu.be/_qLFkM-XjhI

Reviews about Fluconazole

Due to the high fungicidal activity of this drug, patient reviews and doctors' reviews of Fluconazole are mostly positive. Patients, leaving reviews about Fluconazole Teva, as well as reviews about Fluconazole Stada on the forums, write that the drug helps to quickly and effectively eliminate the symptoms of fungal diseases. Users mention that the tablets are relatively inexpensive, but at the same time they allow you to completely get rid of nail fungus and other unpleasant diseases. In some cases, it is enough to take Fluconazole 150 mg once to completely overcome the symptoms of the disease.

Very often, women write positive reviews about Fluconazole for thrush . It is noted that the medicine not only relieves thrush, but also helps prevent relapses of the disease.

Symptoms and causes of thrush

Thrush in women develops due to the proliferation of yeast-like microorganisms. They also have a name - Candida fungus. When the fungus begins to develop in the vaginal area, the vaginal mucosa is affected.

Candida microorganisms are always present in the human body. In a healthy state, their number is reduced to a minimum. Therefore, the disease does not develop.

But if the following reasons happen to a woman, then favorable conditions are created for the development of fungus:

hypothermia;
taking contraceptives;
chronic organ disease;
reduced immunity.

The development of a pathogenic microorganism leads to the appearance of candidiasis. Before using the medicine, you should study the symptoms of thrush.

During the course of the disease, a woman experiences the following symptoms:

burning and itching in the vagina;
redness of the mucous surface;
cheesy white discharge;
pain when urinating;
discomfort during sexual intercourse.

The symptoms described may relate to another type of sexually transmitted disease. Therefore, self-medication is a last resort method that should be resorted to in extreme cases.

The disease itself is not venereal. If the female body is predisposed to the development of this fungus, then the disease can occur regardless of the frequency of sexual intercourse.

If a woman cannot determine what type of pathology her symptoms belong to, then she can look at photos on the Internet. Pathology is divided into 2 types: acute and chronic.

The acute form makes itself felt in the following ways:

copious white discharge;
irritation in the groin area;
painful sensations when touched;
the appearance of a rash on the skin;
itching and burning even after a hygiene procedure;
swelling of the genital organ;
frequent urge to go to the toilet in a small way with painful sensations;
pain or discomfort during sexual intercourse.

The causes of inflammation are changes in the vaginal microflora. The number of beneficial bacteria is sharply reduced, which allows pathogenic candida microorganisms to multiply unhindered. The chronic form makes itself felt with less pronounced symptoms.

In chronic form, pathology can develop under the following circumstances:

damage to the vaginal or genital mucosa;
hormonal disorders that arose due to pregnancy, illness, therapy;
indiscriminate use of antibiotics;
decreased immunity;
lack of vitamins in the body;
dysbacteriosis;
excessive use of personal hygiene products;
poor quality underwear;
drinking alcohol and smoking;
eating junk food;
violation of personal hygiene rules;
stress and overexertion.

The pathology becomes chronic due to untimely treatment, early withdrawal of medications prescribed by a doctor, or lack of treatment at all. Unlike the acute course of the disease, the course of treatment for the disease increases. Despite this, Fluconazole works great for thrush and in the chronic course of the disease.

If the disease manifests itself, you should contact a medical institution for a full examination. Only a doctor can determine the dosage and how many days you need to take the pills.

Fluconazole price, where to buy

The price of Fluconazole tablets depends on the packaging and manufacturer. You can buy Fluconazole in Moscow at prices ranging from 10 to 290 rubles. Capsules 150 mg (1 piece in a package) can be bought for 10-200 rubles. Capsules 50 mg can be purchased at a price of 25 rubles (7 pcs in a package). The cost of Fluconazole Teva 150 mg is 190-220 rubles per pack. (1 PC.).

The price of Fluconazole in Ukraine (Odessa, Kyiv, etc.) is 17-20 hryvnia (50 mg capsules, 7 pcs.). Price Fluconazole 150 mg in Kharkov, Zaporozhye, Dnepropetrovsk, etc. - on average 30 hryvnia (2 pcs per package). 150 mg tablets can be bought in Ukraine for an average of 20 hryvnia.

How much tablets for thrush cost in Kazakhstan and Belarus depends on the packaging and manufacturer. In Minsk, you can buy 150 mg capsules for 10,000 – 103,000 rubles, depending on the number of tablets in the package and the manufacturer.

How much other forms of release of the drug with fluconazole (suppositories, ointment, cream) cost also depends on the manufacturer.

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