How to use Genferon suppositories during menstruation

Genferon suppositories activate the immune system and help the body fight thrush pathogens. The advantage is that it can be prescribed to men. Pregnant women, as they are most susceptible to thrush, can use Genferon starting from the second trimester. A minimum of contraindications and side effects determine its widespread use by doctors. Experts warn about the dangers of independently calculating the dosage and starting treatment without consulting a doctor.

Causes of vaginal candidiasis

We have identified several main factors for the occurrence of thrush in women (although there are several times more reasons):

• Pregnancy.
• Long-term use of antibiotics without the use of probiotics.
• Poor nutrition – abuse of sweets, fatty, spicy, salty foods.
• Immunodeficiency.

All of the listed reasons for the appearance of a pathological condition come down to one thing - a violation of the body’s defenses. Due to weakened immunity, it is easier for a fungal infection to penetrate the human body, because there are no barriers in its way.

Prevention of finger fungus

Age and social status do not affect protection from the fungus in any way, since it can live absolutely anywhere. However, most often these are wet areas - a swimming pool, sauna, bathhouse, public beach. If the human body is weakened by chronic diseases, and the skin is covered with wounds and cracks, the likelihood of “catching” a skin fungus increases. To avoid this, it is important to follow a few simple recommendations:

• If you have to work with acidic or alkaline liquids, be sure to wear gloves. This way you will protect your skin from the appearance of wounds and microcracks.
• Do not take antibiotic medications unless necessary. Medicines of this type destroy all bacteria, including those vital to the body. Prolonged and uncontrolled use of antibiotics leads to a weakening of the defenses, which makes the likelihood of getting sick higher;
• When visiting nail salons, choose a trusted nail technician. Before treating your nails, make sure that the special instruments are sterile. In everyday life, use only your own manicure tools. Try not to injure your nails - mushrooms can enter the body even through the smallest cracks.

Functions of the drug Genferon for thrush

The scope of application of this medicine is multifaceted. Thus, it is used in the treatment of diseases such as chlamydia, vaginosis, trichomoniasis, balanitis, herpes and other infectious, inflammatory diseases of the genitourinary system. In relation to fungal infections of the genus Candida, the drug Genferon for thrush has the following effect:

• Antifungal - the medicine suppresses the activity of candida, helps to quickly reduce the number of pathogenic microorganisms during the first day of use.
• Analgesic effect - helps to quickly relieve pain, itching, burning in the genital area.
• Regenerating effect - the medicine promotes rapid healing of the vaginal mucosa and restores damaged tissue. The regeneration process takes place quickly, without side effects.
• Antibacterial , antiviral effect - in addition to the antifungal effect, the medicine simultaneously suppresses the growth of pathogenic bacteria and viruses.
• Immunomodulatory effect - the product strengthens the immune system, promotes the growth of leukocytes, the action of which is aimed at effectively combating the fungus.

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Contraindications

It is important to start treatment with the drug after examination by a doctor.
"Genferon" will help support the body during the fight against thrush or other infectious diseases. The condition for a quick and safe cure is a correctly calculated dose and time of administration. It is important to consider contraindications for use. To do this, the doctor must conduct research, study the anamnesis and give the patient a test. "Genferon Light" is prescribed with caution to people with intolerance to medications.

Release form of the medicine for candidiasis, its composition

The drug is available in the form of suppositories for vaginal or rectal use, as well as in the form of tablets, syrup, solution and ointment. To treat vaginal candidiasis, doctors most often prescribe suppositories.

The composition of suppositories for insertion into the vagina includes the following components:

• Interferon - plays the role of an immunomodulator; this component increases immune defense at the cellular level.
• Taurine – has an anti-inflammatory, restorative effect. Thanks to this amino acid, micro damage to the vaginal mucosa heals very quickly.
• Anesthesin is a substance due to which the patient quickly disappears the unpleasant and painful symptoms caused by thrush.
• Citric acid - restores normal microflora, as a result of which the fungus dies.

Indications

Among the indications for the use of Genferon suppositories are:

• genital herpes;
• STIs: chlamydia, ureaplasmosis, mycoplasmosis, trichomoniasis;
• thrush or chronic vaginal candidiasis;
• bacterial vaginosis;
• HPV infections;
• colpitis;
• cervicitis;
• vulvovaginitis;
• bartholinitis;
• adnexitis;
• urethiritis;
• cervical erosion.

Genferon suppositories can be used vaginally or rectally, thereby expanding the spectrum of action of the drug.

Scheme for using medication for the treatment of vaginal candidiasis

The drug Genferon should be used only after consultation with a specialist. It is the doctor who will tell you in what dosage the drug should be used. After all, vaginal suppositories are available in dosages of 125, 250, 500 thousand IU, as well as 1 million IU. The doctor prescribes the required dosage based on the clinical picture, the patient’s age, possible complications, and characteristics of the body.

Genferon suppositories for thrush are used as follows:

• At the initial stage of the disease with acute signs of the disease, administer the suppository twice a day for ten days.
• In acute form, use the medicine three times a day. The duration of the treatment course is two weeks.
• In the chronic course of the disease, administer one suppository at a time. After administration, wait two or three days and reintroduce the suppository, and so on. The duration of treatment in this case can be three months.

Patients should understand that the medicine Genferon actively acts on the fungus and quickly eliminates the symptoms of thrush. But this does not mean that after the patient stops being tormented by itching, burning and pain in the genital area, she should stop treatment. In no case, because then the disease will return again in a few days. Even if all the symptoms have passed, you need to go to the end, be treated for as many days as the doctor prescribed.

Similar means

The drug "Genferon" for the treatment of thrush has a list of medications that will help replace the original medication in case of contraindications. You cannot select the medications yourself, as you may make a mistake in the dosage. The patient should study the instructions for use for proper use of the substitute. Avonex, Alfaron, Bioleukin, Gepon, Derinat, Imunogran, Lykopid, Pegintron, Symbioflor, Cycloferon and Erbisol are widely used in the treatment of thrush.

Different opinions of users about the drug Genferon

On the forums you can find various reviews about Genferon suppositories for thrush. Some write that this is the best drug for candidiasis, others note its disadvantages: the appearance of side effects, addiction. Due to the fact that this product contains immunomodulatory ingredients, adverse reactions may indeed occur. They are expressed as follows: trembling, inexplicable fatigue, short temper, apathy, loss of appetite. However, none of the patients writes that the drug is useless. On the contrary, most people note that the suppositories act quickly and the symptoms of the disease go away very quickly.

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In order for the drug to really help you and not lead to side effects, you need to choose the right dosage of suppositories, frequency and duration of their use. And for this you should visit a specialist, because only he knows which patient to prescribe suppositories in what quantity.

Side effects

Improper use of the Genferon suppository can cause unpleasant consequences for the patient. There is no obvious deterioration in health, but the patient complains of discomfort. To minimize the likelihood of side effects, it is enough to strictly follow the doctor’s instructions and avoid unauthorized changes in the regimen of use. Side effects are:

• itching at the injection site;
• headaches;
• minor changes in laboratory tests;
• feeling tired;
• lack of appetite;
• slight change in body temperature.

Recommendations that will protect you from thrush

To prevent the appearance of vaginal candidiasis, you must follow these rules:

1. Always use personal hygiene products - towel, underwear, razor, soap.
2. Use condoms, especially when changing partners.
3. Stop wearing synthetic underwear. It creates a greenhouse effect, the skin stops breathing normally in it, resulting in an ideal environment for the appearance and spread of fungal infections.
4. Wear comfortable, not tight clothes.
5. Limit intake of sweets, fatty, salty foods, canned food. These products not only lower the body's defenses, but also feed the fungus. For him, pickles and sweets are the most favorable habitat.
6. Change your pads regularly, try not to use panty liners because they create a greenhouse effect.
7. Treat chronic diseases in a timely manner.
8. When taking antibacterial drugs, be sure to take probiotics - agents that normalize the intestinal microflora and prevent the occurrence of dysbiosis.

Dosage form and active ingredients

Genferon is used in the local treatment of candidiasis (thrush). It is produced in the form of white or pale yellow suppositories of an oblong shape with a pointed end on one side. The medicine is sold in cardboard packs, each containing 5 or 10 suppositories, packaged in blisters.

The drug has a combined composition. Its active ingredients are human recombinant interferon alpha-2b, benzocaine and taurine. The concentration of interferon in one suppository is 250,000, 500,000 or 1,000,000 IU. The content of benzocaine and taurine for all types of medicine is the same and is 55 mg and 10 mg, respectively. Additional components of the product are sodium citrate, citric acid, solid fat, polyethylene glycol 1500, emulsifier T-2, dextran 60000, polysorbate 80, water.

Thanks to the combined composition, Genferon has a comprehensive effect on the problem area. It suppresses the activity of the Candida fungus, which is responsible for the development of thrush, as a result of which a woman’s white, cheesy vaginal discharge disappears, pain, itching and burning disappear, and the microflora of the genital organs, disturbed by the pathological process, is restored.

Genferon suppositories help not only get rid of vaginal candidiasis, but also reduce the likelihood of its recurrence in the future. This allows them to be used in the treatment of chronic thrush, in which other medications are ineffective.

What complications will arise if the pathology is not treated?

If a woman does not follow the doctor’s instructions or self-medicates, then she risks not only getting a chronic course of the disease, but also developing problems such as:

• Infertility – thrush can lead to the formation of adhesions in the cervix, which can become an obstacle to pregnancy.
• Spontaneous abortion (if a pregnant woman has thrush).
• Cystitis, pyelonephritis.
• Complete refusal of sex , lack of libido.

Ointment for fungus on hands

Universal remedies for hand fungus have not yet been developed. Different types of fungi react differently to tablets, ointments and other medications, so before starting therapy it is necessary to identify the pathogen.

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Medicines for the fungus are divided into two groups - general and systemic. The second ones are necessary if the virus has passed through the nail fold, entered the bloodstream and spread throughout the body. Remedies for fungus of the second group include:

1. Terbinafine is a fungal remedy that comes in the form of white capsule-shaped tablets. The therapeutic effect of the drug is its destructive effect on pathogenic fungi, causing them to stop growing and die.
   Terbinafine is contraindicated in cases of hypersensitivity, severe liver and kidney diseases, and under 2 years of age.

   If used carelessly, side effects may occur: anemia, edema, lupus erythematosus, headache, depression, bloating. The average cost is 350 rubles.

2. Griseofulvin is a broad-spectrum antifungal drug. Inhibits the growth of pathogenic microorganisms at the initial stage. Accumulates in the skin and nails, helping them to be more resistant to fungal infections. Promotes the separation of infected keratin, which is subsequently replaced by new tissue.
   Contraindicated during pregnancy and breastfeeding, with hypersensitivity, systemic lupus erythematosus, blood diseases, and under 2 years of age.

   Causes side effects such as: headache, fatigue, nausea and vomiting, urticaria, angioedema. The average price of Griseofulvin is 325 rubles.

3. Mycozoral is an antifungal drug taken locally or systemically. Contraindicated in case of chronic liver pathologies, lactose intolerance and under the age of three years. Side effects include decreased appetite, headache, dizziness, anemia and skin reactions. The average cost is 500 rubles.

Terbinafine Griseofulvin Mycozoral

If the listed remedies do not suit you in terms of cost, try to cure mycosis with more affordable analogues: Bifonazole - up to 100 rubles, Diflucan - 180 rubles, Flucostat - 200 rubles.

Interaction

The drug is well tolerated by patients. Local allergic reactions (burning sensation in the vagina) are possible. These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor.

Phenomena that occur with the use of all types of interferon alfa-2b, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia, may be observed, but more often they occur with significant exceeding the daily dose over 10,000,000 IU. To date, no serious side effects have been observed.

As with any other interferon alfa-2b drug, if the temperature rises after its administration, a single dose of paracetamol in a dose of 500–1000 mg is possible.

Genferon® is most effective in combination with drugs (including antibiotics and other antimicrobial drugs) used to treat urogenital diseases.

Non-narcotic analgesics and anticholinesterase drugs enhance the effect of benzocaine.

Benzocaine reduces the antibacterial activity of sulfonamides.

The drug is strictly prohibited for use by women in the first trimester of pregnancy. At this stage, the organs and systems of the unborn child are actively forming, and the active substances of the drug can harm the development of the fetus. In later stages of pregnancy, suppositories are used only on the recommendation of the attending physician and under his supervision. Unauthorized use of this remedy for herpes infection by pregnant women is strictly prohibited.

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The drug should be prescribed with caution to people who suffer from allergic reactions on the skin. Excipients of the drug can provoke the appearance of an additional rash, but this is an allergic one. This restrictive aspect applies only to those people who have an individual tendency to allergies. As a rule, in healthy people there are no such phenomena on the skin.

Like any other medicine, Genferon suppositories have some side effects, the presence of which is possible if a person is prone to certain diseases. In most cases, if the dosage specified in the instructions for use is followed, there are no side effects from the drug. If the patient exceeds the dose of the drug, the following side effects may occur:

1. Thrombocytopenia. This is a disruption in the functioning of one of the main components of blood - platelets. The patient may experience nosebleeds and poor blood clotting when injured.
2. Leukopenia. The level of leukocytes in the blood decreases. Resistance to biological agents entering the body from the environment decreases. A person feels a general loss of strength and chronic fatigue.
3. Headache. Even severe migraines can develop, which can only be relieved with the help of strong painkillers.

If the correct dosage is observed and there are no blood diseases, such side effects almost never occur. During the treatment of genital herpes, you need to abstain from sexual activity, or use barrier contraceptives. It is forbidden to have sexual intercourse with a partner within 2 hours after using Genferon suppositories. Failure to comply with this rule may lead to a lack of proper medication effect.

It is important to remember that type 2 herpes infection, which manifests itself as a rash on the external genitalia, is a contagious disease transmitted during unprotected sexual contact. Therefore, proper protection will prevent the development of a disease such as genital herpes.

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Pharmacodynamics

Immunobiological properties

Genferon® is a combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects.

The composition of the drug Genferon® includes recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli, into which the human interferon alpha-2b gene was introduced using genetic engineering methods.

Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested primarily by an increase in cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation.

This is achieved through the activation of CD8 T killer cells, NK cells (natural killer cells), increased differentiation of B lymphocytes and their production of antibodies, activation of the monocyte-macrophage system and phagocytosis, as well as increased expression of molecules of the major histocompatibility complex type I, which increases the likelihood recognition of infected cells by cells of the immune system.

Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, the production of secretory IgA is restored. The antibacterial effect is mediated by immune system reactions enhanced by interferon.

Taurine helps normalize metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug.

Benzocaine (anesthetic) is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane, and blocks the conduction of nerve impulses. Prevents the occurrence of pain impulses at the endings of sensory nerves and their conduction along nerve fibers. It has an exclusively local effect, without being absorbed into the systemic circulation.

Use during pregnancy and breastfeeding

Indicated use for normalization of local immunity during pregnancy 13–40 weeks as part of complex therapy of genital herpes, chlamydia, ureaplasmosis, mycoplasmosis, CMV, human papillomavirus infection, bacterial vaginosis in the presence of itching, discomfort and pain in the lower parts of the urogenital tract.

Clinical studies have proven the safety of intravaginal use of the drug Genferon® 250,000 IU during pregnancy 13–40 weeks.

The safety of using the drug in the first trimester of pregnancy has not been studied.