Suppositories with nystatin for thrush in gynecology + how to take pills for candidiasis + use for menstruation

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

What is nystatin ? This is a polyene antibiotic with antifungal activity. Shows activity against yeast-like fungi Candida . against bacteria . Has a fungistatic effect. Resistance of fungi to the drug develops slowly.

The structure of nystatin contains double bonds, which determine its affinity for the formation of the cell membrane of fungi - the substance molecule is embedded in the membrane and forms channels for the transport of electrolytes into the cell. An increase in osmolarity inside it leads to death. The cell lyses, losing its resistance to external osmotic forces.

Pharmacokinetics

When taken orally, it is almost not absorbed into the gastrointestinal tract. Does not accumulate with repeated doses. Excreted through the intestines.

The active substance of ointments and suppositories when applied externally is not absorbed through the mucous membrane and skin.

Indications for use

For vaginal suppositories

• candidiasis of the vulvo-vaginal area ;
• prevention of fungal diseases with local antibiotic .

For tablets

• prevention of fungal diseases in the postoperative period during operations on the gastrointestinal tract ;
• candidiasis of internal organs of the skin and mucous membranes ;
• prevention of gastrointestinal candidiasis during long-term antibiotic therapy .

Indications for use of ointment

Candidiasis of the skin and mucous membranes .

Instructions for use of Nystatin (Method and dosage)

The drug has several forms of release, so we will consider the instructions for use of all dosage forms.

Nystatin tablets, instructions for use

How to take the pills? The tablets are taken orally, regardless of food intake. They are swallowed without chewing. Nystatin tablets are prescribed to adults for candidiasis of internal organs , 500,000 units 6-8 times a day. Duration of treatment is up to 14 days. The average daily dose is 1,500,000 - 3,000,000 units. For generalized candidiasis - up to 6,000,000 units per day, repeated courses are given after 2 weeks.

For children under 1 year of age, the dose is 125,000 units, from 1 to 5 years - 250,000 units, over 13 years - 500,000 units, dosage frequency 3-4 times a day. Duration of treatment is up to 14 days.

Nystatin ointment, instructions for use

Nystatin ointment is intended for external use; it is applied in a thin layer to the skin or mucous membranes 2 times a day for 10 days. Often combined with oral tablets. For stomatitis in a child, apply ointment to the affected areas 3 times a day after meals, treatment continues for at least a week.

If local irritation , skin rash or urticaria , the drug is discontinued.

Nystatin suppositories, instructions for use

Vaginal suppositories Nystatin are inserted deep into the vagina. The dosage regimen is individual. Usually 1 candle in the morning and evening. The duration of treatment is 14 days. During menstruation, treatment is not interrupted. During the treatment period, avoid sexual intercourse. Treatment of the sexual partner is necessary. During pregnancy, suppositories with Nystatin are used as prescribed by a doctor in case of urgent need.

Contraindications and side effects

“Nystatin” is not recommended to be combined simultaneously with taking “Clotrimazole” in any form of release, since the first significantly reduces the effectiveness of the second drug. There is no information about other drug interactions.

Antifungal.

• The tablets may cause nausea, vomiting, bitter taste in the mouth, diarrhea, chills, abdominal pain, and allergic reactions.
• Suppositories - burning and itching, local allergic reactions.
• Ointment - rash, irritation of skin and mucous membranes, urticaria.

Hydrocortisone reduces the effect of nystatin, and it reduces the activity of clotrimazole. Suppositories are chemically incompatible with hydrogen peroxide, potassium permanganate, salicylic and lactic acids, sodium bicarbonate.

If the above phenomena occur during the treatment of candidiasis with Nystatin, the drug should be discontinued. It is also not recommended to drink alcohol throughout the course of therapy, as it can reduce the effect of the treatment and cause some side effects, such as nausea or vomiting.

The use of Nystatin for thrush is contraindicated in the following cases:

• Sensitivity and intolerance by the patient to any component of the drug.
• Allergy to the components of the medication.
• Pregnancy and breastfeeding period.
• Diseases of the digestive system.

Only a doctor, based on test results, can coordinate the course of treatment and give individual advice on how to take Nystatin for candidiasis

Nystatin during pregnancy

Pregnancy is a predisposing factor for the development of vulvovaginitis . The main thing in this situation is the safety of treatment. The instructions include contraindications for the use of nystatin during pregnancy, since there is no information about their safety for the fetus. Nystatin suppositories can be used during pregnancy only in exceptional cases when the benefit to the mother outweighs the risk to the fetus. Reviews from forum visitors confirm that the drug in this form is sometimes prescribed to pregnant women for short courses of treatment.

The use of ointment is contraindicated during pregnancy. However, it has been proven that the active substance is not excreted in milk when used externally, so breastfeeding can be continued during treatment with the ointment. Do not apply the ointment to the area of ​​the mammary gland and nipple.

Approximate price of the drug

and etc.

The price of nystatin starts from 25-30 rubles per 15 g tube of ointment. Nystatin suppositories for thrush and tablets cost about 40-50 rubles. There are more expensive analogues of this medicine - it makes sense to use them if the fungus has developed resistance to nystatin itself, or if you are intolerant to the drug.

In other cases, it is not worth overpaying for expensive substitutes - nystatin has the same properties as expensive drugs for candidiasis.

Nystatin is an inexpensive and effective remedy against candidiasis, which is available in the form of tablets, suppositories, as well as ointments and creams. The doctor will tell you which form of the drug to choose. Nystatin tablets should not be taken if you have diseases of the liver, pancreas or stomach problems.

It is unacceptable to use medications containing nystatin without a doctor's prescription. If the dosage is calculated incorrectly, a person may develop resistance to the main substance, and next time it will help worse or not help at all.

Nystatin for thrush

Candidiasis of the genital mucosa and oral cavity is called thrush . The main method of treating mild and moderate oral thrush is local treatment in the form of mouth rinses and treatment of the affected areas with a solution of this drug.

Women often experience candidal vulvitis or vulvovaginitis . Vaginal cream or ointment is recommended for the treatment of vulvitis, and tablets and suppositories for vaginitis. For mild vulvovaginitis, local treatment is sufficient - vaginal tablets or suppositories: micogal, clotrimazole, Klion-D. Suppositories with nystatin for thrush have recently been rarely used, since most strains of the Candida fungus have become insensitive to it. The drug has a mycostatic effect, not mycocidal. This provides temporary relief, making you feel better, but leads to relapse. Reviews from forum visitors also speak about this.

If there is no other choice, or the woman has an individual intolerance to the above drugs, then Nystatin is prescribed.

How to take Nystatin suppositories for thrush? They are inserted deep into the vagina 2 times a day. It is very important that the sexual partner also treats with antifungal tablets. If treatment is not carried out, there is a possibility of re-infection of the woman. For mild cases of the disease, drugs for local treatment can be replaced with a single dose of Fluconazole .

For recurrent candidiasis , which tends to exacerbate more than 4 times a year, a combination of local and systemic administration of drugs with one active ingredient is necessary. So, ointment and tablets for thrush are applied topically orally. The following treatment regimen is also possible: a suppository with Nystatin 250,000–500,000 units at night for 14 days, a thin layer of ointment on the mucous membrane of the vulva and vagina 2 times a day for 14-21 days, and tablets of 500,000 units 4 times a day for up to 10 days.

If there is a combined infection (yeast-like fungi and various bacteria), then complex drugs are used, which include nystatin: Macmiror , Terzhinan , Mikozhinaks , Polizhinaks .

Nystatin and its release forms

The drug is also available in the form of ointments, which is used in the treatment of balanoposthitis in men.

The antimycotic is also produced in the form of suppositories for rectal and vaginal administration for vaginal candidiasis, as well as for anal thrush.

The creators of the drug Nystatin made sure that patients could choose the most convenient method of treatment with this medicine and successfully use it.

Shapes:

• vaginal suppositories;
• ointments;
• rectal suppositories;
• pills.

Rectal suppositories are prescribed by a doctor if pathogens are in the rectum. The drug is administered rectally 2 times a day, the course is 2 weeks. Vaginal nystatin suppositories for thrush are most often prescribed. In order for the diagnosis to be as accurate as possible, a woman is given a vaginal culture test.

Nystatin ointment for thrush is also prescribed by the doctor at each stage of the disease. More often it is prescribed in the presence of a urogenital infection. It is necessary to lubricate the affected tissues at least 2-3 times a day, the course is 10-14 days. In case of a complex course of the disease, the doctor may recommend inserting a tampon well coated with nystatin ointment vaginally. It is recommended that the patient undergo a flora sensitivity test before prescribing the ointment.

Nystatin in tablet form is actively used by doctors for the treatment and prevention of thrush. It must be remembered that this medicine belongs to the group of antibiotics.

Vaginal suppositories, tablets, ointment.

Nystatin analogues

Level 4 ATC code matches:
Colistin

Alpha Normix

Pimafucin

Analogs of the polyene series: Levoy , Natamycin ; imidazoles: Ketoconazole , Miconazole , Clotrimazole ; triazoles: Fluconazole , Intraconazole .

Reviews about Nystatin

Nystatin tablets, what are they for? This is an antifungal drug used to treat candidiasis , a fungal disease that can occur with damage to the skin, nail plates, mucous membranes and internal organs ( generalized candidiasis ). Candidiasis of the genital mucosa and oral cavity is called thrush. The main method of treating mild to moderate oral thrush is local treatment. Adults can dissolve the tablet after meals 3-4 times a day or lubricate the affected areas of the oral mucosa with ointment. For newborns, a tablet of nystatin 250,000 units is crushed and dissolved in a small amount of water. Drops of the resulting solution are applied to a gauze swab and the areas are treated 3-4 times a day. Children from 2 years of age can be given the drug orally, 1/4 tablet three times a day, and the oral mucosa can be treated with the drug “ Candide ”.

Reviews of Nystatin suppositories for thrush are associated with side effects: increased urination, irritation, burning sensation in the vagina. Women often stopped treatment immediately after the symptoms disappeared, while the pathogen was not eliminated and the symptoms returned after a while. According to many women, these suppositories are not very effective; they believe that the drug is “outdated” and prefer modern antimycotic drugs. There are also reviews that these suppositories were prescribed during pregnancy to treat thrush.

Reviews of Nystatin tablets are most often associated with its prescription for the prevention of dysbacteriosis during long-term use of antibiotics. From the first days of antibiotic treatment, many patients were prescribed 250,000 units 4 times a day. It is effective only for the prevention of intestinal candidiasis, since its systemic absorption is 3–5% and it does not affect fungi outside the intestine. When taking the tablets, side effects were observed in the form of nausea and stool upset. In order to prevent candidiasis infections, this drug is immediately introduced into tablets containing an antibiotic. Thus, Tetracycline with nystatin are used for bronchitis , tonsillitis , furunculosis , tracheitis , cholecystitis , purulent skin infections and acne .

Nystatin ointment was used to treat superficial candidomycosis of the skin and in cases of mild disease, good results were noted. For severe fungal skin infections, local application of ointment alone was not enough and systemic antimycotics ( Fluconazole ) were prescribed.

Which suppositories are not dangerous in the treatment of thrush in pregnant women?

Nystatin tablets for thrush are prescribed to both children and adults. The dosage and treatment regimen will be slightly different.

About Nystatin tablets, instructions for use contain the following information:

1. Adults and children over 13 years old - 1 tablet (50,000 units) up to 4 times a day or 1 tablet (250,000 units) up to 8 times in 24 hours.
2. Children from 5 to 12 years old - 1 tablet (250,000 units) 4 times a day.
3. Children from 1 year to 5 years - 1 tablet (250,000) once a day.
4. Infants - ½ tablet (250,000 units) per day.

The minimum course duration is 10 days, the maximum is 14 days. In case of a recurrent form, the course of therapy is repeated after a week's break.

Sex during the period of treatment for thrush with Nystatin is extremely undesirable. In addition, it is recommended to conduct therapy with two partners at once.

Nystatin for thrush is a medical drug that should not be prescribed to yourself, as this can lead to complications. Only a qualified doctor can make a diagnosis and prescribe a course of treatment after the necessary examination.

The specific course and treatment of thrush with nystatin is prescribed based on data about which organs are infected. The use of the medicine and the dose can be local or systematic. Representatives of the beautiful woman are prescribed suppositories and ointments, and men are prescribed nystatin ointment and tablets. Getting rid of the disease of male representatives of the 2nd type:

• Locally. It is necessary to lubricate the affected head of the penis at least 2-3 times a day.
• Combined view. Simultaneous use of ointments and tablets, taken 2-4 times a day.

Separately, it is worth mentioning the tablet form of the medicine. It is forbidden to break or chew them. You need to drink it with water. The dose is prescribed by the attending physician and must be strictly followed. Nystatin tablets are often prescribed for candidiasis of the oral cavity and vagina.

Rectal suppositories are recommended when the fungus is localized in the intestinal area. If after examination a thrush of the genital organs is detected, then the doctor prescribes it for both partners, even if the man claims to be healthy and has no symptoms of the disease. In cases where one of the partners has not been treated, there is no guarantee of success in treatment or the longevity of a positive result, since any of the individuals may be a carrier of the fungus.

https://youtu.be/Dl0VXc2YSJs

Periods when the body especially needs treatment:

• Exacerbation of candidiasis.
• Chronic thrush.
• Candidiasis dysbacteriosis.

There are cases when a patient is intolerant to Nystatin, the drug Flucanazole or Diflucan its analogues. During treatment, sexual intercourse is possible only with the use of a condom, that is, a barrier method of treatment.

When treating thrush with Nystatin, you must adhere to the following basic rules:

• Women are not recommended to use vaginal suppositories during their periods.
• You cannot drink alcohol at the same time.
• Limit the consumption of fried, smoked and salted foods.
• It is not recommended to take Clotrimazole at the same time, as the effect of treatment will decrease.
• Both partners must undergo treatment.
• It is better to abstain from sexual relations during the period of therapy.
• Carry out a repeat therapeutic course after 14-20 days.

Treatment of candidiasis in the early stages in a woman can be carried out using suppositories and ointment with nystatin

Treatment of thrush with Nystatin in women and men allows you to achieve the desired effect in a fairly short time. The drug has an effect on fungal infection at any stage of the disease. But you should remember that you should not choose medications for treatment on your own, as this can lead to undesirable health consequences.

Nystatin price, where to buy

You can buy nystatin preparations for thrush at any pharmacy, they are available for free sale and you do not need a prescription in Latin, written out by a doctor. Their cost is reasonable. Thus, the price of Nystatin in suppositories ranges from 84-92 rubles, the price of Nystatin in tablets No. 20, 500,000 units. is 20-28 rubles, and the price of Nystatin ointment 30 g is 49-75 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Nystatin sup.
  vaginal 500 thousand units 10 pcs. PJSC Biosintez 168 rub. order

Pharmacy Dialogue

• Nystatin suppositories (sup. vag. 250TE No. 10) Biosynthesis OJSC

  50 rub. order

• Nystatin (tablet p/o film. 500TE No. 100 (blister sheet)) Belmedpreparaty

  134 RUR order

• Nystatin ointment (tube 100 units 30 g) Biosynthesis OJSC

  82 RUR order

• Tetracycline + nystatin (tablet 100 mg + 22.2 mg No. 10) Biosynthesis OJSC

  93 RUR order

• Nystatin suppositories (sup. vag. 500TE No. 10) Biosynthesis OJSC

  170 rub. order

Europharm* 4% discount using promo code medside11

• Nystatin vaginal suppositories 500000 units 10 pcs Biosynthesis PAO

  120 rub. order

• Nystatin rectal suppositories 500000 units 10 pcs Biosynthesis OJSC

  129 RUR order

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Pharmacy24

• Nystatin ointment 15g PAT "Lubnipharm", Ukraine
  18 UAH. order
• Nystatin 500000 OD No. 10 rectal suppositories PAT Monfarm, Ukraine

  59 UAH order

• Nystatin 500000 units No. 20 tablets PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine

  23 UAH order

PaniPharmacy

• Nystatin ointment Nystatin ointment 100000U/g 15g Ukraine, Lubnyfarm PJSC

  21 UAH order

• Nystatin suppository Supp. with nystatin 500000 units No. 10 Ukraine, Monfarm JSC

  50 UAH order

• Nystatin suppository Supp. with nystatin 250000 units No. 10 Ukraine, Monfarm JSC

  42 UAH order

• Nystatin tablets Nystatin tablets. p/o 500000ED No. 20 Ukraine, Health LLC

  20 UAH order

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Compatibility with alcohol and drugs

Frequency of administration: for adults – up to 8 times a day, for children – up to 4. There is no connection to food intake.

The dosage for adults is selected individually, taking into account the form, stage and characteristics of the disease. The instructions indicate: maximum 6,000,000 units (for generalized thrush). But doctors say that the fungicidal effect appears when consumed ≥ 10,000,000 units per day, which corresponds to 20 tablets. Simply put, 3-4 tablets at a time.

A single dose for children under 3 years of age is 25,000 units, a daily dose is 100,000 units.

The standard duration of therapy is 10-14 days.

Opinions about this medicine, as well as about any other, are different. Out of 10 respondents, 7 speak positively about the drug. Among the advantages, these people name:

• efficiency;
• affordability;
• no side effects (practically not absorbed, does not accumulate in the body).

Main disadvantages: long course of treatment, bitter taste.

One nuance cannot be ignored: 70% of respondents selected the drug on their own (without consulting a doctor or undergoing tests).

3 people complain about the absolute ineffectiveness of the tablet form of this antimycotic, but praise suppositories with nystatin.

It’s curious: economically “savvy” comrades calculated that they needed 14 packages of No. 20 for the full course of treatment, and the cost was 1,680 rubles. Agree, it's not that cheap.

99 out of 100 competent specialists consider this option obsolete and prescribe other systemic drugs. The reason is resistance. Simply put, the resistance of pathogenic microorganisms to therapeutic effects.

The tablet form of Nystatin for thrush according to the old scheme is recommended by doctors working in the outback far from the achievements of pharmaceuticals. And patients who are treating themselves buy it in accordance with previously received recommendations.

Nystatin interacts with a small number of drugs as it passes through the body. Possible consequences when used together are indicated in the table.

When using ointments and suppositories, the active substance does not enter the general bloodstream and does not interact with ethanol. But drinking alcohol is not recommended because it affects the metabolism of carbohydrates.

In addition, alcohol increases the concentration of sugar in the blood, which is a good environment for the proliferation of fungi. This negatively affects the effectiveness of therapy. The use of tablets affects the condition of the liver; in this case, drinking alcohol is prohibited.

Candida fungi, which actually cause the disease, are present in the body of almost every healthy person. The problem arises when they begin to multiply excessively due to concomitant unfavorable factors.

Such factors may be a weakened immune system, colds, pregnancy, taking antibiotics, severe stress, or contact with an infected sexual partner. Thus, no one is immune from the occurrence of the disease.

Nystatin is an effective and widely known treatment for thrush, which has been successfully used to combat the disease for many years. Nystatin has various forms of release (tablets, ointment, vaginal and rectal suppositories), which ensures its effective use for the treatment of different patients.

The drug Nystatin is an antibiotic whose destructive effect is aimed at fungi of the genus Candida and Aspergillus. The main active ingredient of the drug is nystatin. In small quantities it slows down fungal cells, in large quantities it kills. It is poorly absorbed into the gastrointestinal tract, which explains its gentle effect on the body.

But some doctors consider Nystatin to be an outdated drug with many side effects, so they prescribe more modern analogues of the drug. In addition, some strains of Candida fungi are capable of developing resistance to nystatin.

The drug is available in the following basic forms:

• tablets – small, round, light yellow in color, dosage 250, 500 thousand units; excipients - sugar, calcium stearate, talc, potato starch, dyes;
• ointment - dosage 1000 thousand units per 1 g; includes excipients such as lanolin and petroleum jelly;
• vaginal suppositories - dosage 250, 500 thousand units; Excipients include propyl ester of parahydroxybenzoic acid, food grade citric acid, Witepsol N-15, Witepsol W-35;
• rectal suppositories - dosage 250, 500 thousand units; The excipients are the same as for vaginal suppositories, plus Vaseline oil.