Curantil during pregnancy - what is it prescribed for: indications for use and side effects of the drug

Category: Published 01/06/2017 · Comments: · Reading time: 4 min · Views: 4,268

Curantil tablets help prevent the formation of blood clots and restore the body’s defenses. What does this medicine help with? The drug improves blood circulation. The instructions for use suggest using “Curantil” tablets for the prevention and treatment of thrombosis and heart diseases.

Pharmacological properties

Curantil tablets, which help the medicine prevent the formation of blood clots, have antiplatelet, vasodilating and immunomodulatory effects. The drug dilates blood vessels, increases the speed of blood circulation and its quantity, and improves oxygen supply to the heart muscle.

The drug is actively used for the treatment of many cardiovascular pathologies due to the ability of the active substance to prevent thrombus formation. The use of Curantil tablets during pregnancy helps prevent blockage of the placental vessels.

As a result, the likelihood of complications associated with manifestations of hypoxia and insufficient oxygen for the child is significantly reduced. The immunomodulatory properties of the drug are due to the formation and increase in interferon activity.

This allows the medicine to be used for the prevention and treatment of influenza and colds. After taking the tablet, the maximum effect is observed after 1 hour.

Why is Curantil recommended during pregnancy?

In obstetric practice, the prescription of Curantil tablets is a standard scheme for the prevention of intrauterine pathologies in the fetus. The main nutrition to the baby comes through the placenta and umbilical cord, which are penetrated by a network of small blood capillaries.

The smaller the lumen in the bloodstream, the worse the transport of oxygen, nutrients and minerals to the embryo. This is fraught with hypoxia and inhibition of the development of organs, systems, and weight gain.

In most cases, pregnancy proceeds normally, but if a woman has a genetic predisposition to thrombophlebitis, the likelihood of full development of the fetus is at risk.

If the expectant mother does not know about the problem, then the pregnancy may be unsuccessful. Due to the formation of blood clots in the bloodstream of the umbilical cord or in the placenta, fetal development is impossible. At 10–14 weeks, a frozen pregnancy or miscarriage can be diagnosed.

To prevent such cases, a woman is prescribed Curantil throughout pregnancy according to a regimen individually selected by the gynecologist and with constant monitoring of the well-being of the woman and the fetus.

Additionally, an analysis is carried out to determine the qualitative characteristics of blood viscosity and the possibility of blood clots.

Contraindications

Doctors and the instructions forbid taking the Curantil tablet if:

liver failure;
low blood pressure;
atherosclerosis of the coronary arteries;
hypersensitivity to the drug "Curantil", from which these tablets can cause allergies;
obstructive pulmonary pathologies occurring in severe form;
heart failure;
angina pectoris;
kidney failure;
collapse;
complicated hypertension;
aortic stenosis;
ailments that cause bleeding;
hemorrhagic diathesis;
myocardial infarction;
severe arrhythmia.

Overdose symptoms, treatment

The cardiovascular and nervous systems respond most quickly to exceeding the permissible dose of Curantil.
On the part of the heart and blood vessels, there is a decrease in total blood pressure, tachycardia (increased heartbeat), redness of the skin and a feeling of heat in the body. The central nervous system and its peripheral parts react with the development of general weakness and dizziness. Currently, no antidote has been identified. To quickly eliminate the most severe symptoms, it is recommended to stop taking the medication. Next, intravenous administration of the drug “Aminophylline” is prescribed in a volume of up to 100 mg. If an attack of angina pectoris (or any other heart reaction) develops, Nitroglycerin is prescribed - 1 tablet under the tongue.

In addition, symptomatic treatment is carried out in accordance with the severity of the patient's condition. Hemodialysis in case of an overdose of the drug "Curantil" (medical reviews confirm) will not give a positive effect.

Medicine "Curantil": instructions for use

Taking tablets "Curantil 25"

During influenza epidemics, as well as to prevent respiratory viral infections, you need to drink 50 mg of the drug once a week (2 tablets). Take the medicine for a month.

To prevent recurrent incidence of ARVI, especially for persons with a predisposition to these ailments, 100 mg of the drug per day is prescribed. Drink 2 tablets with an interval of 2 hours. The duration of therapy takes 2-2.5 months.

Instructions for use of tablets "Curantil 75"

The dosage is determined by a specialist depending on the complexity of the pathology and the individual characteristics of the patient. To reduce platelet aggregation, Curantil 75 is taken in the amount of 1-3 tablets per day. In difficult cases, the dosage can reach 0.6 g.

To treat coronary heart disease, you need to take 1 tablet of 75 mg every 8 hours. It is possible to increase the volume of the drug taken. To prevent thrombosis and in case of impaired cerebral circulation, 3 to 6 tablets per day are prescribed. The maximum daily dose is 0.45 g.

Use during pregnancy

An individual approach to the selection of a treatment regimen is required. The standard dose can be 25 mg three times a day.

Before or after meals?

How to take Curantil is explained in the instructions for use. The medicine is taken before meals with half a glass of water. Do not chew the tablets.

Release form and composition

There are such forms of release of this drug as tablets, dragees and intravenous solution.

Release form	Description
Pills	They have a yellow, sometimes with shades of green, color. The dosage can be 25, 50, 75 or 100 mg - this is indicated immediately on the package, for example, Curantil 75.
Dragee	They may contain 25 or 75 mg of the active ingredient and are placed in dark glass bottles.
Solution	Placed in transparent glass ampoules, the concentration is 0.5%. Each container contains 2 ml with 0.01 g of active substance.

The composition of the drug of any form includes the active element dipyridamole.

Additional substances in tablets:

Macrogol 6000 - a polymer of ethylene glycol, is a substance for cleansing the intestines. It is not absorbed into the bloodstream at all and is released in its original quantity.
Lactose monohydrate acts as a sugar substitute in medicines.
Povidone k-25 is used to prepare medicinal solutions.
Corn starch does not have a medicinal effect; it is only needed as a filler for tablets.
Titanium dioxide is used in the preparation of tablets and capsules. Gives a white color and is a filler.
Hypromellose is a universal additional substance for the preparation of solid forms of drugs, used for granulation.
Magnesium stearate is an emulsifier, often synthetic, used as an auxiliary element.

Curantil and, in particular, dipyridamole, improves the movement of blood through the vessels. This occurs due to the fact that the active substance of the drug prevents platelets from sticking together. In addition, it expands arterioles - the smallest arteries, even smaller than capillaries. The uniqueness of the component is that this effect does not affect large arteries and vessels. Dipyridamole also increases the body's resistance to a harmful external environment, that is, it promotes the functioning of the immune system. When dipyridamole enters the body, it triggers the synthesis of interferon, making it more resistant to viral infections.

The highest concentration of the main substance in plasma is achieved an hour after oral administration. Communication with plasma proteins is almost complete. Dipyridamole tends to accumulate in red blood cells - erythrocytes and in the heart. The substance dipyrimidol tends to be deposited in gallstones. Metabolization of the active component occurs in the liver due to communication with glucuronic acid. The half-life is 20-30 minutes, exit from the body is with bile.

Side effects

The drug "Krantil" can cause:

tides;
headache;
arthritis;
hyperemia;
noise in ears;
tachycardia;
thrombocytopenia;
weakness;
diarrhea;
heartbeat;
bradycardia;
myalgia;
skin rash;
nausea;
ear congestion;
decreased blood pressure;
hives;
vomiting;
bleeding;
dizziness;
rhinitis;
epigastric pain;
excessive bleeding during surgery.

special instructions

In case of an overdose of "Curantyl 75", blood pressure sharply decreases, tachycardia occurs, and severe weakness appears. It is necessary to rinse the stomach, induce artificial vomiting and drink absorbents (hydrolytic lignin, activated carbon).

To avoid disruption of the normal functioning of the stomach, the drug is washed down with milk.

To normalize intracardiac blood flow in the event of circulatory disturbances in the myocardium, Amminophylline is prescribed.

When driving vehicles, you should be careful. If there is a sharp decrease in pressure, it is better not to drive

Analogs of the drug "Curantil"

Drugs that have a similar effect:

"Clopidogrel."
"Tromboneti".
"Aspirin Cardio"
"Dysgren."
"Plavix".
"Cardiomagnyl".
"Aspecard."
“Godasal.”
"Plagril."
"Aspicor".
"Zilt."
"Brillinta."
"Atrogrel".
"Magnicor".
"Atherocardium".

Drug interactions

When using the drug, it is necessary to take into account interactions with other medications:

With simultaneous use, Curantil enhances the effect of antihypertensive drugs.
When used together, Curantil may weaken the anticholinergic effects of cholinesterase inhibitors.
When used simultaneously, xanthine derivatives weaken the vasodilator effect of Curantil.
With simultaneous use of Curantil with anticoagulants or acetylsalicylic acid, the antithrombotic effect of the latter increases and, accordingly, the risk of developing hemorrhagic complications.

Consumer opinion about a pharmaceutical product

Consumer reviews about the effectiveness of Curantil tablets are mostly positive, although there are comments from patients who did not notice a difference from their prescription. There are many discussions on forums for young mothers about the advisability of prescribing pills during pregnancy:

Tatyana, 27 years old “I took Curantil during pregnancy as prescribed by my gynecologist. I thought that I had some problems, but in the corridor I heard from other girls that it was prescribed to everyone, without exception, at the initial stage of fetal development. The doctor explained that this is necessary for adequate nutrition of the fetus, so that the lumen of the blood artery in the umbilical cord and in the capillaries of the placenta is normal and blood circulation is not inhibited. I didn't argue. It’s necessary, that means it’s necessary! The baby was born without pathologies and with good immunity, because she herself was not sick. Later I learned that it is recommended as a prophylaxis against influenza and viruses, and not only for pregnant women.”

Anzhelika, 26 years old “To give birth to my first child, I had to go through a lot. Several attempts failed, although I considered myself completely healthy and all the tests confirmed this. After my third miscarriage, I was referred to a geneticist, who ordered a test to determine my susceptibility to blood clots. It turns out that during pregnancy the likelihood of blockage of a blood vein in the umbilical cord increases several times. The diagnosis was confirmed. I was prescribed a complex treatment, which included Curantil. I drank it constantly during pregnancy, but under the close supervision of my gynecologist and therapist. Everything was successful and I finally became a mother. Everything is fine with the child. Girls, do not refuse the treatment proposed by the doctor, and do not look for pitfalls in this if you want health for yourself.”

What does Curantil 25 help with: indications

Treatment and prevention of ischemic cerebrovascular accidents
encephalopathy
primary and secondary prevention of coronary heart disease, especially with intolerance to acetylsalicylic acid
prevention of arterial and venous thrombosis and treatment of their complications
prevention of thromboembolism after heart valve replacement surgery
prevention of placental insufficiency during complicated pregnancy
microcirculation disorders of any type (as part of complex therapy)
prevention and treatment of influenza, ARVI (as an interferon inducer and immunomodulator) - for taking the drug in a dose of 25 mg.

Patients' opinions about "Curantil"

The opinions of people who took Curantil both in connection with various diseases and during pregnancy are both positive (the majority of such reviews) and negative.

Patients who took the drug for cerebrovascular accidents speak well of the medication. And the headaches practically go away, and the dizziness and feelings of constant general weakness cease to bother me. The majority of reviews from pregnant women about Curantil are also positive. A woman’s body, which works under heavy overload, must provide the developing child with oxygen and nutrients in full. And if there are problems with the vessels of the brain, heart, or blood microcirculation, this medication will come in very handy.

However, negative opinions about the medication also exist. This is not to say that side effects develop very often, but they do exist. For example, reviews from pregnant women about taking the drug “Curantil” report problems such as headaches and decreased blood pressure. The development of allergic reactions in the form of skin rashes and itching is not so uncommon.

In general, everything is strictly individual. For some, “Curantil” helped get rid of problems, for others it caused undesirable effects. In any case, consulting a doctor and strictly following his instructions will minimize the development of side effects and help achieve a positive effect when treating with this drug.

The antenatal clinic gave me Curantil for free. Drink 3 times a day for two weeks, then take a break for two weeks and drink again. What is it for and who drank it. The contraindications are scary; it says that it should be taken with caution during pregnancy, I don’t have any complications, everything is normal.