Why is Utrozhestan prescribed during pregnancy? Instructions for use of Utrozhestan during pregnancy

During pregnancy, women often have to cope with hormonal imbalances, which often lead to miscarriage and even infertility. Statistics show that a common cause of miscarriage is acute deficiency of progesterone, which is responsible for pregnancy. It is produced by the corpus luteum, which occurs as a result of ovulation and functions throughout the first trimester. If for some reason the body cannot cope with this responsibility, the woman is shown Utrozhestan, an analogue of human progesterone. Let's discuss the use of Utrozhestan during pregnancy and why it is prescribed to women.

Analogs

Only a physician can replace Utrozhestan with an identical drug.

Iprozhin

Catalent France Beinheim (France), Capsugel Ploermel (Italy)

Average cost: caps. 100 mg (30 pcs.) – 351 rub., caps. 200 mg (15 pcs.) – 368 rub.

Progesterone-based drugs are intended to replenish the lack of the hormone and eliminate the complications caused by it.

Iprozhin is produced in gelatin capsules with different concentrations of the active ingredient: 100 and 200 mg. The filler is peanut butter and soy lecithin.

Depending on the indications, the capsules can be used orally or intravaginally.

Pros:

• Stimulates ovulation
• More affordable price compared to other drugs
• Few side effects.

Flaws:

May cause allergies due to peanut oil content.

Crinon

Fleet Laboratories (England)

Average cost: (15 pieces of 1.125 g) – 2482 rubles, 90 g (1 piece) – 187 rubles.

The drug is in the form of a gel for intravaginal administration. Contains progesterone. The drug is used to ensure the luteal phase in preparation for artificial insemination, eliminating MC disorders caused by insufficient levels of the hormone in the body. It is also prescribed for replacement HT for women with menopausal disorders.

Pros:

• Easy to insert
• There is no need to lie down after the procedure
• It helps a lot.

Flaws:

• High price
• Not sold everywhere.

Utrozhestan analogues - other progesterone-based products

Utrozhestan has analogues. It is interesting that among all these drugs there are no obviously cheap ones, that is, you will not be able to save significantly by taking an analogue. However, a substitute drug can help out if the main one is not on sale. Before taking an analogue, you should definitely consult a doctor!

Table: analogues of Utrozhestan and their features

A drug	Release form	Compound	Peculiarities
Duphaston	Coated tablets, available in 20 or 28 pieces per package.	Dydrogesterone (progesterone analogue) 10 mg, excipients.	To maintain proper levels of progesterone, pregnant women are recommended to take 1 tablet 2 times a day, but the regimen is prescribed by a doctor in each specific case. The drug is in many ways similar to Utrozhestan. However, the manufacturer does not list drowsiness among the side effects, and also writes that “the drug does not affect the ability to drive vehicles or use other mechanisms.” For many women this can be important.
Prajeesan	Capsules, pack of 10 pieces.	Progesterone 200 mg, excipients.	As with Utrozhestan, this drug can be taken either orally or intravaginally. The manufacturer's recommended dosage for pregnant women is 200–400 mg 2 times a day.
Iprozhin	Capsules, pack of 15 or 30 pieces	Micronized progesterone 100 mg, excipients.	You can take it with water, or you can insert it into the vagina. To prevent miscarriage, a dose of 100–200 mg twice a day is recommended for pregnant women. The duration of treatment is determined by the doctor.
Crinon	Gel for intravaginal use. Each dose is packaged in a separate single-use vial.	Progesterone, 90 mg per dose, excipients.	Recommended for use when planning pregnancy. Pregnant women are allowed only if pregnancy occurred as a result of IVF and the gel has already been used in preparation for the procedure. In this case, it is used only at the earliest stages of waiting.

Is it possible to use Utrozhestan during pregnancy?

Utrozhestan is not contraindicated in the gestational period and, on the contrary, very often helps prevent miscarriage, so it is prescribed from the moment pregnancy is confirmed. Often women begin to take it at the preconception stage, and then continue treatment after successful conception. Taking Utrozhestan in the second trimester of pregnancy is also possible. However, during treatment, a woman’s liver parameters must be monitored. But taking Utrozhestan during lactation is undesirable, since the mechanism of its penetration into milk is poorly understood.

Utrozhestan in the 1st trimester of pregnancy

Utrozhestan is prescribed in the form of vaginal capsules in the first weeks of gestation. The drug is administered daily and always at the same time. This option of administration prevents pathological effects on the digestive system and toxic damage to the liver. In addition, oral administration in the first trimester is often impossible, for example, if toxicosis occurs.

Prescribing Utrozhestan in the early stages of pregnancy in adequate dosage completely eliminates uterine hypertonicity, stabilizes the functioning of the nervous system, and prevents possible miscarriage, which is associated with progesterone deficiency.

The negative impact of Utrozhestan on the development of the baby is practically absent. However, there is a small risk of developing hypospadias when using progestins to prevent miscarriage. This fetal pathology consists of the formation of an anomaly in the development of the posterior wall of the urethra or its complete absence. Therefore, before prescribing Utrozhestan, a woman should be informed about possible complications in the baby.

Utrozhestan in the 2nd, 3rd trimester of pregnancy

Utrozhestan is prescribed very rarely after the 20th gestational week, since the significance of this treatment at this period is practically reduced to zero. But in exceptional cases, when the placenta cannot cope with the production of progesterone, Utrozhestan in the 2nd trimester of pregnancy can be extended indefinitely.

Most often, such long-term use of Utrozhestan occurs with IVF, cervical insufficiency, and shortening of the uterus. Also, after 20 weeks, Utrozhestan can be prescribed if there is a history of miscarriage, surgery on the cervix, or premature birth.

Sometimes Utrozhestan tablets are prescribed during pregnancy in the 3rd trimester. Taking gestagens after the 30th gestational week is indicated for premature softening of the cervix, its shortening, and the baby’s position is too low. But such treatment is carried out only in particularly dangerous situations, when the risk of premature birth is too high. In addition, in the later stages, taking gestagens can be dangerous in the presence of thrombosis or serious liver disorders. Therefore, if Utrozhestan is indicated, until what week of pregnancy it should be prescribed, the obstetrician-gynecologist decides on an individual basis.

What kind of drug is Utrozhestan?

Progesterone is one of the most important female hormones. It is he who regulates the menstrual cycle, prepares the endometrium for it even before pregnancy, then ensures the process of implantation of the embryo into the uterus, supports pregnancy, and relaxes the uterus. In the early stages of pregnancy, progesterone has an anti-abortion effect: it suppresses the immune response to the embryo.

Progesterone deficiency at the beginning of pregnancy increases the risk of spontaneous abortion, therefore, in case of threatened miscarriage, treatment is aimed primarily at replenishing the lack of this hormone.

Progesterone was first synthesized in 1934, but its use during pregnancy was limited due to its low bioavailability. In addition, when taken, it was quickly destroyed in the liver and simply did not have time to act. The use of progesterone for miscarriage became possible only after the invention of a micronized form, which was registered in Russia under the trademark Utrozhestan. The molecule of the active substance Utrozhestan completely coincides with progesterone, which is formed in the female body. Due to the small particle size (up to 10 microns), Utrozhestan can be quickly and completely absorbed into the blood both from the gastrointestinal tract and from the vaginal mucosa.

The rights to Utrozhestan belong to the Bezek Healthcare group of companies from Belgium. The drug itself is produced in Spain and Thailand, and a Russian drug under the same brand is expected to be released soon.

Pharmacological properties

Progestin drug. Progesterone, the active substance of the drug Utrozhestan, is a hormone of the corpus luteum. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where, activating DNA, it stimulates RNA synthesis. Promotes the transition of the uterine mucosa from the proliferation phase caused by follicular hormone to the secretory phase. After fertilization, it promotes the transition to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the end elements of the mammary gland. By stimulating protein lipase, it increases fat reserves and increases glucose utilization. By increasing the concentration of basal and stimulated insulin, it promotes the accumulation of glycogen in the liver and increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of nitrogen in the urine. Activates the growth of the secretory department of the acini of the mammary glands, induces lactation. Promotes the formation of normal endometrium.

Pharmacokinetics. When taken orally. Suction. Micronized progesterone is absorbed from the gastrointestinal tract. The concentration of progesterone in the blood plasma gradually increases during the first hour, Cmax is observed 1-3 hours after administration. The concentration of progesterone in the blood plasma increases from 0.13 ng/ml to 4.25 ng/ml after 1 hour, to 11.75 ng/ml after 2 h and is 8.37 ng/ml after 3 hours, 2 ng/ml after 6 hours and 1.64 ng/ml after 8 hours after administration.

Metabolism. The main metabolites that are detected in blood plasma are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone.

Excretion. Excreted in the urine in the form of metabolites, 95% of which are glucurone-conjugated metabolites, mainly 3-alpha, 5-beta-pregnanediol (pregnandione). These metabolites, which are determined in blood plasma and urine, are similar to substances formed during the physiological secretion of yellow bodies.

With intravaginal administration. Suction. Absorption occurs quickly, progesterone accumulates in the uterus. A high level of progesterone is observed 1 hour after administration. Cmax of progesterone in blood plasma is achieved 2-6 hours after administration. When administering the drug 100 mg 2 times/day. the average concentration remains at 9.7 ng/ml for 24 hours. When administered in doses of more than 200 mg/day. progesterone concentration corresponds to the first trimester of pregnancy.

Metabolism. Metabolized to form predominantly 3-alpha, 5-beta-pregnanediol. Plasma 5-beta-pregnanolone levels do not increase.

Excretion. It is excreted in the urine in the form of metabolites, the main part being 3-alpha, 5-beta-pregnanediol (pregnandione). This is confirmed by a constant increase in its concentration (Cmax 142 ng/ml after 6 hours).

Cross-drug interactions

When combining Utrozhestan with other drugs, it is necessary to take into account their effect on liver enzymes, as this affects the course of the metabolic processes of progesterone. Accordingly, its concentration will decrease or increase, which will affect the therapeutic effect.

Medicines that enhance liver function include barbiturates, anticonvulsants (for example, Phentitoin), anti-tuberculosis drugs (Rifampicin), the diuretic Spironolactone, and the antimycotic Griseofulvin.

Some types of antibiotics of the ampicillin and tetracycline groups can change the intestinal microflora and, then, the transformation of steroids in the liver. Due to the fact that mutual reactions are influenced by many factors and features of processes in each organism, it is impossible to foresee the consequences in advance.

Progestins have the ability to reduce glucose tolerance, so if treatment is prescribed to a patient with diabetes mellitus, dosage adjustment may be required.

Progesterone can increase the content of Cyclosporine and reduce the effect of Bromocriptine.

The bioavailability of progesterone may be reduced in smokers and increased in drinkers.

When progesterone is combined with ketoconazole, each other's action mutually enhances.

Features of reactions when administering suppositories

There is no data yet on the interaction of progesterone with other substances of medications after the introduction of Utrozhestan into the vagina, since such studies have not been conducted. To avoid possible reactions and difficulty in the release of progesterone, Utrozhestan should not be combined with other intravaginal drugs.

Utrozhestan during pregnancy instructions

The drug fully compensates for the lack of progesterone without disturbing the woman’s natural hormonal balance. Proper treatment does not cause complications, does not contribute to excess weight gain or worsening pregnancy. But the effectiveness of replacement therapy during gestation depends on the adequacy of the prescribed dose and the general dosage regimen.

Utrozhestan during pregnancy - dosage

The treatment course of Utrozhestan depends on the method of its use, the course of pregnancy, and the severity of progesterone deficiency.

• Oral administration of Utrozhestan involves the administration of 200-300 ml of the drug in several doses. For example, 100 ml in the morning, and the rest of the dose at night.
• The Utrozhestan regimen during pregnancy to prevent unscheduled onset of labor looks like this: the expectant mother takes 400 ml of the drug every 7-8 hours until the condition stabilizes, or according to the regimen suggested by the doctor. After the condition improves, the dose of Utrozhestan is reduced to 200 ml. The maintenance dose is taken until the 36th gestational week. A longer course of treatment is not recommended.
• Intravaginal use of the drug involves the administration of 200 ml of progesterone daily. If necessary, it is allowed to increase the dose of Utrozhestan during pregnancy to 400 ml or more.
• To delay premature birth, Utrozhestan 200 during pregnancy is taken from 22 to 36 gestational weeks. If there is a threat of miscarriage, a woman is prescribed 200-400 ml of Utrozhestan vaginally at the same time with an interval of 12 hours. Therapy lasts up to 12 gestational weeks.

There are no problems with how to insert Utrozhestan during pregnancy. The procedure is quite simple and painless. Before removing the capsule from the blister, you need to wash your hands, then take the capsule and insert it into the vagina in a position comfortable for the woman. The use of an applicator is allowed. After the procedure, the woman needs to lie down for some time so that the contents of the capsule dissolve and the substances penetrate into the tissue of the vaginal membrane.

Utrozhestan - contraindications during pregnancy

Utrozhestan may be contraindicated in a pregnant woman if she has the following diseases:

• thrombophlebitis;
• liver damage of various etiologies;
• varicose veins;
• porphyria;
• undiagnosed bleeding;
• neoplasia of the genital organs and mammary glands.

Gestagens tend to retain water in tissues and affect the growth of hormone-dependent tumors. Given this effect of Utrozhestan, its use during pregnancy is limited for the following diseases:

• hypertension;
• epilepsy;
• bronchial asthma;
• kidney dysfunction;
• migraine;
• diabetes;
• cardiovascular abnormalities;
• lupus erythematosus;
• mastopathy;
• benign neoplasms.

Considering the high risk of thromboembolic and metabolic complications, Utrozhestan should be immediately discontinued if the following symptoms develop:

• visual impairment;
• blood clot formation;
• venous insufficiency;
• severe headache, including migraine attack.

Utrozhestan during pregnancy - side effects

Negative consequences from treatment are rare. Sometimes, if treatment rules are not followed or individual intolerance occurs, some disruptions in the functioning of various organs and systems are possible.

• mammalgia;
• amenorrhea;
• bleeding from the birth canal.

• sleepiness;
• absent-mindedness;
• headache;
• dizziness;
• depression.

Gastrointestinal disorders:

• diarrhea;
• nausea;
• occasional vomiting;
• constipation.

Skin damage:

• itching;
• acne;
• hives;
• yellowness of the skin;
• chloasma.

After vaginal administration of Utrozhestan during pregnancy, side effects are local in nature and manifest themselves in the form of unpleasant sensations in the vagina - itching, swelling, burning, hyperemia.

The following adverse reactions may also occur:

• decreased libido;
• localized alopecia;
• thromboembolism;
• short-term fluid retention in tissues;
• minor weight fluctuations;
• hirsutism;
• anaphylactic shock.

How to cancel Utrozhestan during pregnancy

Utrozhestan is a hormonal drug, therefore it needs to be gradually withdrawn so as not to provoke a hormonal imbalance. To successfully discontinue the drug without consequences, the daily dose is reduced by 100 ml every week. If the dose taken is low enough, it is reduced by 50 ml at intervals of three days. At the stage of dose reduction and until Utrozhestan is completely discontinued during pregnancy, the woman is constantly monitored so that she does not start bleeding.

Features of the use of Utrozhestan by pregnant women

The treatment regimen for Utrozhestan should be chosen by the doctor depending on the nature of the complications, risks for the course of pregnancy, restrictions on use and the consequences of using the drug for the health of the mother. Self-medication is unacceptable.

When taking the capsules orally, it is recommended to take them with water. Their intake should be separated in time from meals. It is best to take the drug at night, as it causes drowsiness . Usually the daily dose is divided into two or three doses.

The intravaginal method of use involves deep insertion of the capsule into the vagina. Before carrying out the procedure, you must follow the usual hygiene rules: washing and washing your hands. Utrozhestan is allowed to be used for vaginal bleeding, although in this case it is also possible to switch to oral administration.

Utrozhestan can be taken for a long time . If pregnancy occurs as a result of IVF, it is recommended to use gestagen during the first two trimesters. To prevent premature birth, the drug is administered from the 22nd to the 34th week.

Utrozhestan should be discontinued gradually over a week, reducing the dose by 100–200 mg. There are suggestions that abrupt withdrawal may provoke a threat of termination of pregnancy.

Indications for use

Hormonal drugs are designed to replenish the lack of progesterone in the female body and thereby eliminate conditions resulting from its deficiency.

Oral administration of the hormone is indicated for:

• Infertility caused by insufficient luteinization
• Vivid manifestations of PMS
• MC disorder due to ovulation disorders or ongoing amenorrhea
• Fibrocystic mastopathy
• Premenopause (first stage of menopause)
• Replacement HT in peri- and postmenopausal women (together with drugs containing estrogens).

Utrozhestan is used vaginally:

• As a means of HRT to correct the lack (or absence) of progesterone due to non-functioning/absent ovaries
• To prevent miscarriage or premature birth in pregnant women with various complications
• To ensure luteinization during preparation for IVF
• To normalize luteinization in spontaneous or induced MC
• Menopause occurring earlier than expected
• Together with estrogen-containing drugs in replacement HT
• Infertility due to insufficient luteal phase
• Preventing habitual or threatened abortion due to insufficient progesterone in the body.

What is it prescribed for?

When does the doctor prescribe taking a progesterone-containing drug? Utrozhestan is prescribed both to mothers carrying a child and to those who are just planning a pregnancy or have problems with the reproductive system. Progesterone plays an important role in the menstrual cycle, so it is necessary not only for expectant mothers, but also for women who are not yet planning to conceive a baby.

The table provides information on the indications for prescribing Utrozhestan:

During pregnancy	When planning fertilization	For the treatment of reproductive diseases
The risk of spontaneous abortion with uterine tone due to low progesterone production by the corpus luteum.	Inability to conceive due to luteal insufficiency, which is caused by hypofunction of the corpus luteum. The cause may be dysfunction of the hypothalamic-pituitary system, hyperandrogenism or inflammation of the appendages.	Premenstrual tension syndrome.
The risk of premature birth in women who have abnormalities of the birth canal, such as a shortened cervix, as well as premature rupture of the membranes of the fetus (more details in the article: what is the danger of a shortened cervix during pregnancy?).	Preparatory activities for artificial conception.	Failures of menstruation due to ovulation disorders.
Cystic growth of breast tissue
Hormone replacement treatment in pre- and postmenopause, premature menopause, and with removed ovaries.

Overdose

Symptoms: drowsiness, transient dizziness, euphoria, shortening of the menstrual cycle, dysmenorrhea.

In some patients, the average therapeutic dose may be excessive due to existing or emerging unstable endogenous secretion of progesterone, special sensitivity to the drug, or too low concentration of estradiol.

Treatment: in case of drowsiness or dizziness, it is necessary to reduce the daily dose or prescribe the drug before bedtime for 10 days of the menstrual cycle; in case of a shortening of the menstrual cycle or spotting, it is recommended to postpone the start of treatment to a later day of the cycle (for example, on the 19th instead of the 17th); in perimenopause and with HRT in postmenopause, it is necessary to ensure that the concentration of estradiol is optimal.

In case of overdose, symptomatic treatment is carried out if necessary.

Utrozhestan in late pregnancy

Utrozhestan can be used during late pregnancy if there is underdevelopment of the placenta. If there is chronic recurrent miscarriage, the doctor can play it safe and prescribe it for you after the 20th week and almost until the birth. Utrozhestan is also indicated in the later stages for those mothers who have undergone IVF. It is preferable to use suppositories - they do not affect the liver. You don’t have to worry – the drug does not harm the fetus.

Utrozhestan after 20 weeks of pregnancy

Utrozhestan is rarely prescribed during pregnancy after 20 weeks, since hormonal support after this period actually loses its significance. But it happens that, according to test results, there is still not enough progesterone in the blood, even taking into account the progesterone that the placenta begins to produce at 20 weeks. In this case, it may be necessary to drink Utrozhestan before giving birth. Also, the problem may be relevant if pregnancy occurred as a result of artificial insemination and in women with isthmic-cervical insufficiency.

Utrozhestan at 22 weeks of pregnancy

Utrozhestan during pregnancy at 22 weeks is prescribed for shortening of the cervix, as this can cause premature birth due to the threat of early dilatation. If you have a history of miscarriages, missed abortion or premature birth, the doctor may also prescribe Utrozhestan to be on the safe side. There's nothing wrong with that. Follow his recommendations strictly and when the time comes, discontinue the drug according to the prescribed regimen. It will definitely help you give birth to a healthy baby on time, without causing any harm to him, since it contains a plant analogue of progesterone.

Utrozhestan at 30 weeks of pregnancy

Utrozhestan at 30 weeks of pregnancy is prescribed for a short, soft cervix and if the baby is located low in the uterine cavity. If a doctor prescribes Utrozhestan for you at this period, then he has a reason for it, so you should not refuse - it can be dangerous for the baby. Of course, the drug is mainly used in the early stages, but each clinical case is completely individual. Trust the experts.

Overdose

Accidental or intentional intake of a large number of capsules may provoke undesirable reactions, manifested in the form of:

• Drowsiness, hypersomnia
• Brief dizziness
• Reducing the duration of the MC
• States of euphoria
• Dysmenorrhea.

In some women, intoxication may occur even at the recommended dose if she has unstable progesterone secretion. Intoxication is also facilitated by individual hypersensitivity to the main substance or too low estradiol content.

How to eliminate an overdose

If the drug causes drowsiness and dizziness, then the patient should reduce the dosage of the drug or take capsules before bedtime for 10 days of MC.

If the MC changes or spotting occurs, it is advisable to delay the start of MC therapy for several days.

To cope with other manifestations of intoxication, symptomatic therapy is prescribed.

Instructions for use and rules of administration in different release forms

The method of using Utrozhestan differs depending on the stage of pregnancy. There is also a difference if the medicine is taken orally and intravaginally. Despite the fact that the package contains instructions for use, the attending doctor can independently draw up a treatment regimen that the woman will have to follow. How should you use Utrozhestan in different trimesters?

1st trimester

Why are hormones prescribed in the early stages? In the first trimester, the medicine is prescribed to eliminate the tone of the uterus and prevent miscarriage. It is often prescribed to mothers whose previous pregnancies ended in spontaneous abortion. It is prescribed mainly at the 5th week of gestation, when bleeding from the vagina may appear.

In the early stages, Utrozhestan is used in the form of suppositories when there is a threat of miscarriage. They are placed in the vagina and left until completely absorbed. It is best to administer the suppository at night, attaching a pad to your underwear. In this way, the woman will be protected from unpleasant incidents if the medicinal suspension stains her underwear.

Dosage – 200 – 400 mg/day. Candles must be inserted 2 times a day at the same time. How long do you need to lie down after inserting the capsule? Typically about an hour, so it's best to administer them at night. If intravaginal administration is not suitable, you can take the medicine as tablets. You should not drink them with food; it is better to consume them on an empty stomach.

2nd trimester

In the second trimester, pregnancy may be in jeopardy due to a sharp decrease in the body's production of progesterone and increased uterine tone. This occurs between 13 and 22 weeks of gestation. Hormone deficiency is determined by test data. Sometimes the level is so low that even the amount produced by the placenta is not enough for a successful and safe pregnancy. Expectant mothers who conceived through in vitro fertilization, as well as those with a pathological condition of the cervix, are at risk.

If there is a risk of miscarriage, the treatment regimen is the same as in the 1st trimester. Utrozhestan can be taken orally and vaginally, 2 capsules at a dose of 200 – 400 mg/day. If pregnancy occurred through artificial conception, the dosage is increased to 600 mg/day.

3rd trimester

Why are hormones prescribed at the end of pregnancy? In the third trimester, Utrozhestan is prescribed vaginally when the cervix is ​​shortened, if the fetus has dropped low in the uterine cavity, to prevent premature birth. Usually the appointment is scheduled from 30 weeks.

The medicine is inserted into the vagina once a day. To minimize discomfort, this can be done before bedtime, introducing a suppository at night. Dosage – 200 mg/day.

How long does it take to be absorbed and how is it excreted?

Utrozhestan is absorbed quite quickly. If used as a tablet, it is quickly absorbed from the digestive system, and maximum plasma concentrations are observed after 1 to 3 hours.

When inserted into the vagina, the medicine begins to act a little slower. The maximum content of progesterone is detected 2–6 after administration. The effect lasts for 24 hours.

The drug is excreted through the kidneys in urine. Metabolites of progesterone, mainly pregnandione, are found in the urine. They are similar to those substances that are secreted by the corpus luteum under natural conditions.

Utrozhestan price

The drug is produced by pharmaceutical companies in France, Thailand, and Spain, commissioned by the Belgian group of companies BESINS HEALTHCARE. In Russia, DOBROLEK is engaged in the production of secondary packaging. The price of the drug depends on the concentration of the active substance and the number of capsules in the package. The average cost of medicine in Moscow is shown in the table below.

Manufacturer	Release form	Cost in rubles
OLIC	Capsules, 100 mg, 28 pieces	433
Capsules, 200 mg, 14 pieces	463
BESINS LAB (France)	Capsules, 100 mg, 30 pieces	455
Capsules, 200 mg, 14 pieces	485
CINDEA PHARMA	Capsules, 200 mg, 14 pieces	399

Instructions for use of Utrozhestan

As noted above, the peculiarity of Utrozhestan capsules is that they can be used both orally and vaginally. The treatment regimen is determined only by the attending doctor, based on the individual characteristics of the woman’s body and the severity of the disease.

The oval capsule of Utrozhestan contains 200 mg of progesterone

How to administer capsules intravaginally

Medical specialists prefer the intravaginal method of using Utrozhestan. This is explained by the fact that the absorption of the drug occurs much faster. The medicine acts directly on the inner layer of the uterus. The concentration of the hormone in plasma reaches a maximum after 2–3 hours. Using more than 200 mg daily dose is likely to increase progesterone levels to the required level.

Before carrying out the intravaginal procedure, you must wash your hands thoroughly to avoid infection. Next, you need to complete the following steps:

• lie on your back;
• bend your knees and bring them closer to your chest;
• insert the capsule deeply with your finger or applicator.

With certain skill and necessity, this procedure is carried out while sitting or standing.

The dose of Utrozhestan for vaginal administration is selected based on the following therapeutic goals:

• threatened abortion or recurrent miscarriage - from 200 to 400 mg per day, divided into two doses;
• risk of premature birth - 200 mg at night;
• conducting an IVF cycle - from 200 to 600 mg per day;
• infertility due to impaired function of the corpus luteum - from 200 to 300 mg per day from the 17th day of the menstrual cycle for ten days.

How to take Utrozhestan orally

Capsules are advised to be taken orally if irritation of the mucous membrane is observed when they are inserted into the vagina. For most diagnoses, the medicine must be taken at night and after waking up with water. To achieve the required level of progesterone, it is usually enough to take 200–300 mg of medication per day. If there is a risk of miscarriage or the woman is diagnosed with recurrent miscarriage, the dose may be increased by 100–300 mg.

Utrozhestan during pregnancy information about capsules

Utrozhestan is a drug from the group of sex gland hormones. It is a natural gestagen that can completely replace female progesterone.

The active component of Utrozhestan is micronized progesterone, enclosed in a gelatin capsule for intravaginal administration, as well as for oral administration. The capsule additionally contains glycerin, oil, and gelatin.

Externally, Utrozhestan capsules during pregnancy resemble elastic dragees based on gelatin, their color is pale yellow, there is no aroma, the shape of capsules with a dose of 100 ml is round, and capsules with a dose of 200 ml are oval.

The special formula of the active substance ensures complete absorption of Utrozhestan by the intestinal or vaginal mucosa. Progesterone, penetrating into the blood, performs all the functions of a female hormone. It takes part in preparing the endometrium for implantation of the fertilized egg into the walls of the uterus, reduces the muscle activity of the uterus and fallopian tubes, thereby preventing egg rejection. In addition, progesterone supports the fetus until the placenta is fully formed and prepares the female glands for future lactation.

The bioavailability of Utrozhestan is the same for internal and vaginal use. However, Utrozhestan suppositories during pregnancy provide faster penetration of progesterone and a pronounced local effect. Even with the introduction of an average dose of Utrozhestan (100 ml per day), reactive penetration of progesterone into the body occurs, which allows maintaining its normal level of 9.7 ng/ml, which corresponds to the luteal phase. Thus, taking Utrozhestan allows the endometrium to mature from the proliferation phase to the secretory phase and be successfully implanted into the fertilized egg. A gradual increase in the dose of Utrozhestan to 200 ml completely compensates for the need for progesterone during the 1st trimester.

Description of the drug

The main active ingredient of the drug Utrozhestan is progesterone. It is this hormone that is responsible for the normal course of pregnancy at various stages. The medicine is produced in the form of capsules with a soft shell and a stretchy base. These capsules usually have a yellow tint. Inside the gelatin shell there is an oily whitish suspension. It does not have a pronounced taste or smell.

At the beginning of pregnancy, gestagen (progesterone) has a positive effect on the structure of the uterine mucosa, which is necessary for the successful implantation of a fertilized egg. Later, it has a reducing effect on the contractility of the reproductive organ, which prevents increased tone and termination of pregnancy from developing. In addition, the hormone is directly involved in preparing the mammary glands for lactation.

The drug Utrozhestan is intended for oral administration or vaginal administration. The rate of absorption depends on the method of application. With vaginal administration, the desired therapeutic effect is achieved faster than when taking the hormone orally.

Overdose

Sometimes doctors prescribe an excessively high dose of medication for patients. This error may be caused by unstable production of progesterone by the woman’s endogenous system or low concentration of estradiol. The main symptoms of overdose include drowsiness, decreased menstrual cycle, euphoria, and dizziness. Treatment is symptomatic:

1. If dizziness or drowsiness occurs, reduce the dosage of the drug and postpone its administration to the end of the day before bedtime. The recommendations are followed for 10 days of the menstrual cycle.
2. If spotting or changes in the duration of menstruation appear, treatment begins on the 18th or 19th day of the cycle.
3. If side effects occur during the period of taking HRT and perimenopause, it is necessary to donate blood for hormones to determine the concentration of estradiol.

How to stop treatment correctly

For each woman using Utrozhestan, an individually selected withdrawal regimen is used. She must take into account the duration of pregnancy and the dosage of the medication. Most often, the amount of hormonal substance is reduced every 3-7 days, carefully monitoring the patient’s condition.

If any alarming symptoms occur after reducing the dose, you should return to the previous dosage at which the woman felt normal.

Expectant mothers receiving maximum doses of the hormone require the most attention. If after the first reduction in the amount of the active substance for 5 days there are no dangerous signs, then you can continue with the withdrawal.

An approximate drug withdrawal regimen for a woman who took it in the 1st trimester with a threat of miscarriage at a dose of 200 mg per day looks like this:

• at 11-12 weeks, a woman uses 100 mg in the morning and evening;
• at week 13 - only 100 mg at night;
• at week 14 – 100 mg every other day before bedtime;
• at week 15 the medication is completely stopped.

If the threat of miscarriage is serious, the woman complains of spotting, abdominal pain and other symptoms, she is prescribed an increased dosage, for example, 400 mg of progesterone daily until 13-14 weeks (200 mg twice a day).

Next, the medication is discontinued according to the following scheme:

• at week 15, a woman should take 200 mg at night and 100 mg in the morning;
• at week 16 – 200 mg before bedtime;
• at week 17 – 100 mg at night;
• Completely cancel after 18 weeks.

The use of Utrozhestan during the IVF protocol also requires higher doses, which are divided into 2 doses, and the completion of treatment occurs by 20-21 obstetric weeks.

Here is an approximate withdrawal regimen for a woman receiving 800 mg of a hormonal substance every day:

• at week 15, the expectant mother should take 400 mg in the morning (2 capsules with a dosage of 200 mg) and the same amount of hormone in the evening;
• at week 16, the morning dose is reduced, that is, the woman will receive 200 mg in the morning, and the evening dose remains 400 mg;
• at week 17, the dosage at night is also reduced, so the pregnant woman takes 200 mg of the hormone twice a day;
• at week 18 you should take 200 mg at night and only 100 mg in the morning;
• at week 19 – 100 mg twice a day;
• at week 20 - only 100 mg at bedtime;
• At 21 weeks, use is stopped.

If pregnancy, despite the prescription of Utrozhestan, cannot be maintained, the medication can be discontinued abruptly.

Often this increases the contractile activity of the uterus and allows it to independently reject the dead fertilized egg, so curettage is no longer necessary. Such a cancellation can only be carried out if there are reliable signs of miscarriage - after an ultrasound, blood tests and a medical examination. They do not use any special regimens; they simply stop taking the capsules.

The use of Utrozhestan receives mostly positive reviews, noting the high effectiveness of the drug both in the first trimester and at a later date. Women confirm that taking the capsules eliminated pain in the lower abdomen, spotting and other signs of a threatened miscarriage.

Expectant mothers who stopped using the medicine slowly and according to the regimen prescribed by the doctor indicate that the gradual reduction in dosage did not cause any harm to their health or the condition of the baby. Those same patients who, out of ignorance, sharply reduced the dose, noted a deterioration in their general condition and were forced to consult a doctor.

How does the medicine work?

After using the drug, immediate absorption of the active substance into the blood begins. When taken orally, the drug produces an effect within 3-4 hours. If the vaginal method of administration is used, the capsules begin to act within 1-2 hours.

The drug actively spreads throughout the body and has an effect primarily on smooth muscles. Thus, progesterone helps the endometrium transition from one phase to another. When pregnancy occurs, Utrozhestan tablets support normal progesterone production and help relax the reproductive organ. If there is a threat of abortion, the drug relieves tone from the uterus and stops bleeding, which is caused by a lack of hormone.

The drug is excreted mainly in the urine after 12-16 hours. That is why, if it is necessary to maintain progesterone levels, you need to use the product at regular intervals.

Features of use at different times

"Utrozhestan" refers to drugs that are allowed to be used throughout the entire gestational period, so it is prescribed both in the 1st trimester and at a later date.
Quite often, such a medication is prescribed during preparation for conception, if pregnancy does not occur due to insufficient progesterone levels or any diseases of the uterus (endometriosis, fibroids). In this case, treatment with Utrozhestan must be carried out under the supervision of a doctor. Prescribing it to yourself and using it just in case is unacceptable. The specialist must make sure that the woman has a progesterone deficiency and the use of such a hormone is really justified, because the threat of miscarriage is not always caused by a hormone imbalance. The cause may be genetic pathologies and then progesterone drugs do not help.

In the early stages, Utrozhestan is most often administered vaginally. This method reduces the load on the expectant mother’s digestive tract and ensures a faster effect of the medicine. In addition, oral use in the first months of pregnancy is often impossible due to severe nausea or frequent vomiting. The use of capsules helps eliminate hypertension and reduces the risk of possible miscarriage due to progesterone deficiency.

In the 2nd trimester, Utrozhestan is used in cases where the production of progesterone by the placenta is insufficient. At this time, the drug is received by expectant mothers who are carrying a baby after IVF, as well as patients with cervical insufficiency. Indications for taking capsules in later stages are also various problems with a previous pregnancy, for example, if a woman suffered a miscarriage, she had surgical manipulations on the cervix, or she had a premature birth.

For some pregnant women, the drug is prescribed in the 3rd trimester. The use of "Utrozhestan" at this stage is necessary if the cervix has shortened and softened ahead of time, and the baby is located too low. These signs of a high risk of premature birth are the main reason to prescribe capsules in the third trimester, however, due to the risk of side effects, the medication is used only in situations that are dangerous for the woman and baby, when the benefits of treatment outweigh the possible harm.

Utrozhestan during pregnancy

Women while expecting a baby may experience hormonal imbalances, leading to miscarriage and miscarriage. Medical research shows that the most common cause of child loss is progesterone deficiency. Gynecologists prescribe Utrozhestan during pregnancy if the patient:

• low (insufficient) progesterone level according to laboratory test results;
• in the past there were spontaneous abortions (miscarriages) in the first trimester or childbirth at 22-37 weeks;
• IVF procedure was carried out;
• the pregnant woman was taking this medication at the time of conception;
• shortening of the cervix while expecting a baby.

Many patients taking Utrozhestan ask the question: “Until what stage of pregnancy should I take it?” Only the treating gynecologist determines the duration of its use. Usually the drug is taken until the end of the first trimester, less often - until the 20th week. In exceptional situations, it is used until childbirth. Cancellation of Utrozhestan during pregnancy is a lengthy process that requires utmost attention. Abruptly stopping it may cause spontaneous abortion or worsen your health. Typically, the dose of Utrozhestan during pregnancy is reduced in stages, over one to one and a half months.

Utrozhestan during pregnancy. Photo: no2.htgetrid.com

How to take Utrozhestan

Utrozhestan during early pregnancy is used in a standard dosage - 200 mg before resting at night and in a volume of 100 mg when the need arises in the morning.

There are the following schemes for how to take medicine in various situations:

:

1. For premenopause - in a volume of 200 mg, for 10-12 days.
2. During menopause, the duration of use is determined by the gynecologist, the optimal dosage remains 100 mg.
3. For menstrual disorders - in the morning and evening, in the total volume of the substance 300 mg. The course of therapy is no more than 12 days.
4. During IVF - by installation in the vagina. The dose varies depending on the situation within 400-800 mg. Duration – at least two weeks.
5. In case of permanent miscarriage, threat of spontaneous miscarriage - 400 mg per 24 hours, intervaginally.
6. For non-functioning ovaries, when the 13th day of the cycle occurs, you should take 100 mg per day. When the 15th day comes and up to the 25th day, the dosage is increased to 200 mg per day. Then the norm is increased every 7 days.

The procedure must be carried out before bedtime, especially for intervaginal administration.
This is necessary so that the candle does not inadvertently leak out, but remains inside. How much and in what volume to take the drug will be recommended by the attending doctor based on the examination.

Additional information will also be provided by tests and ultrasound examinations.

expectant mother or pregnant woman.

If there is a threat of miscarriage, if necessary, therapy can last from 2 weeks to 1 month. In other situations, treatment does not exceed 12 days.

Indications

Progesterone deficiency conditions in women.

Inside:

infertility due to luteal insufficiency;

premenstrual syndrome;

menstrual irregularities due to ovulation or anovulation disorders;

fibrocystic mastopathy;

premenopause;

hormone replacement therapy (HRT) for peri- and postmenopause (in combination with estrogen drugs).

Intravaginally:

hormone replacement therapy in case of progesterone deficiency with non-functioning (absent) ovaries (egg donation);

prevention (prophylaxis) of premature birth in women at risk (with shortening of the cervix and/or anamnestic data of premature birth and/or premature rupture of membranes);

luteal phase support during preparation for in vitro fertilization;

luteal phase support in spontaneous or induced menstrual cycle;

premature menopause;

hormone replacement therapy (in combination with estrogen drugs);

infertility due to luteal insufficiency;

threatened abortion or prevention of habitual abortion due to progesterone deficiency.

Indications, contraindications, side effects

Pregnant women are prescribed Utrozhestan for:

• threat of abortion or if the woman has had abortions before;
• the existing threat of premature birth (when the due date has not yet approached, and the cervix has begun to shorten);
• increased uterine tone.

My doctor prescribed this drug to me after an ultrasound at 7–8 weeks of pregnancy. The reason was the discovery of a corpus luteum cyst (as a result, a possible disruption in the production of progesterone). In addition, the gynecologist drew attention to the insufficient attachment of the fertilized egg to the walls of the uterus. The doctor immediately predicted that I would have to drink Utrozhestan until the middle of the second trimester. In addition to taking hormones, motor rest was prescribed at least until the first screening.

To survive, the embryo must literally “grow” into the endometrium, and this requires progesterone

Women planning pregnancy and those diagnosed with infertility are prescribed Utrozhestan in preparation for the IVF procedure:

• to support the luteal phase (this helps the egg, if fertilized, to gain a foothold in the uterus);
• as hormone replacement therapy if the body does not produce enough progesterone.

In addition, Utrozhestan softens the onset of menopause and improves the quality of life of women who have had their ovaries removed for some reason.

Contraindications to the use of Utrozhestan are:

• thrombosis and thromboembolic disorders;
• bleeding from the vagina with an unknown cause;
• presence or suspicion of malignant tumors of the breast or genital organs;
• porphyria;
• incomplete abortion;
• liver diseases;
• age under 18 years (studies not conducted);
• breastfeeding (passes into breast milk);
• allergic reactions to the components of the drug (especially soy lecithin).

The manufacturer recommends using the drug with extreme caution in women with diabetes, cardiovascular disease, photosensitivity, asthma, and kidney disease.

Like any hormonal drug, Utrozhestan has side effects. If the “side effects” make themselves felt too strongly, then you should talk to your doctor about reducing the dosage.

Women taking this drug may experience:

• drowsiness, dizziness;
• menstrual irregularities, spotting outside of menstruation;
• headache;
• nausea, bloating, constipation or diarrhea;
• skin rashes, itching.

If the side effects are too severe, your doctor may recommend switching from oral to intravaginal: as mentioned above, the capsules can be used in both ways.

special instructions

The hormonal product is not suitable for use as contraception. The medicine is not taken with food, because it increases its bioavailability. The doctor must carefully monitor the condition of patients with depression, because Progesterone may worsen mental disorders. In some women, taking the drug causes a decrease in glucose tolerance. Further use of the drug is unacceptable if:

• visual disturbances and migraines occur;
• thrombotic complications appeared;
• The patient was diagnosed with breast cancer or a predisposition to it.

Rarely, cases of anaphylactic shock caused by a reaction to soy lecithin have occurred in patients. To avoid such incidents, before taking the drug, you should consult an allergist and take allergy tests. If the course of treatment is started early (before day 15), the cycle duration may change and bleeding may occur.

Contraindications

There are a number of situations in which the use of the hormonal agent in question is not recommended. This applies to the following cases:

• Thrombophlebitis in a patient.
• History of thromboembolic disorders.
• Incomplete abortion.
• Bloody discharge in a woman of unknown origin.
• Current or history of intracranial hemorrhage.
• Malignant neoplasms in the breast area.
• Severe kidney disease.
• The girl's age is under 18 years.
• Lactation period.

In addition, Utrozhestan is not prescribed to patients suffering from personal intolerance to the components of the drug.

With extreme caution, the drug is prescribed during pregnancy planning or after conception in case of pathologies of the heart and blood vessels, migraines, and high blood pressure. A special dosage is selected for both types of diabetes mellitus, renal failure, epileptic seizures, and liver diseases.

The drug Utrozhestan side effects

Like any other medicine, this drug can cause negative reactions in the body. It is worth noting that most often this occurs when the drug is used independently without a doctor’s prescription. The drug also causes an unexpected reaction in the body when overdosing or reducing the time between doses. The drug "Utrozhestan" may have the following side effects.

Allergy

If intolerance to any component of the drug occurs, this manifests itself as a skin rash, itching, and redness of the genitals (with vaginal administration). Nausea and vomiting may also occur. All these symptoms must be treated with appropriate medications. The hormonal medicine should be replaced with one with a similar effect.

Changes in the functioning of the excretory organs

When used orally, the drug "Utrozhestan" has side effects in the form of increased and diluted stools. Some patients report constipation and bloating. This may be caused by the effect of the drug on smooth muscle.

In addition, the drug can cause a diuretic effect on the body. This occurs especially often when using appropriate medications. Most often, treatment for such effects is not required, and therapy is not canceled.

Nervous system response

Side effects of the drug may include headache, weakness and drowsiness. Most often, such symptoms appear within 1-3 hours after administration. Doctors advise in this case to choose an alternative drug.

Bleeding from the genital tract

Very rarely, taking the drug may be accompanied by spotting and spotting. You should definitely report this side effect to your doctor and change your treatment regimen if necessary.

Use in different trimesters

Utrozhestan tablets or capsules are usually not used during pregnancy. More often during pregnancy, expectant mothers are prescribed suppositories. They can be used in the first, second and third trimester.

First trimester

In the early stages after conception, you can use it as prescribed by your doctor. Only a specialist can make a decision on prescribing medication based on the woman’s medical examination data.

In this case, it is recommended to insert suppositories into the vagina at the same time of day. This method of administering the hormone helps prevent the negative effect of the drug on the digestive system, in particular on the liver. In the right trimester, Utrozhestan is prescribed for the following purposes:

• Prevention of increased uterine tone and elimination of this condition.
• Normalization of the central nervous system.
• Preventing miscarriage and premature birth.
• Replenishment of progesterone in the body when there is a lack of it.

Utrozhestan does not have side effects on the fetus. This fact is confirmed by numerous medical studies. In extremely rare cases, a child develops a disorder such as an anomaly in the urethra.

Expert opinion

Ksenia Dunaeva

User experience expert and comment moderator. Higher medical education and more than 5 years of actual practice.

Ask Ksenia

It is advisable to minimize the use of any medications, even despite their apparent safety, in the first trimester of pregnancy. This is due to the fact that it is during the first 12 weeks that the formation of all vital organs and systems occurs. Even a drug such as Utrozhestan should be selected exclusively by a specialist. This will help prevent various complications and health problems of the mother and fetus.

Second trimester

In the second trimester of pregnancy, the drug is usually not taken. At this stage, a woman’s body, as a rule, does not experience a lack of progesterone. If this condition does occur, a specialist may prescribe Utrozhestan suppositories to the expectant mother.

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In the second trimester, the medication can be prescribed to pregnant women in the following situations:

• Development of isthmic-cervical insufficiency in the patient.
• Disorder in the form of shortening of the cervix.
• Fertilization was carried out using IVF.

In addition, when caring for a patient, the doctor must take into account the woman’s medical history. If she previously suffered a miscarriage, fetal failure or premature birth, Utrozhestan can be prescribed as a prophylaxis.

Third trimester

Starting from 30-34 weeks of gestation, a specialist can recommend that the expectant mother take the medication in question in the following situations:

• Shortened cervix.
• Too early softening of the reproductive organ and birth canal.
• Low attachment of the placenta.

In this case, the regimen of use and duration of use of Utrozhestan is determined by the doctor depending on the severity of the woman’s condition. Reviews from experts indicate that the use of the product is justified only if the benefits of its use significantly outweigh the risks for the mother and fetus.

The need for treatment with this hormonal medication is assessed individually for each woman, depending on her disease.

Interesting facts about Utrozhestan

• Some planning women prescribe progesterone themselves without passing the necessary tests or consulting a doctor. Independent choice of dosage and medication plan can lead to undesirable consequences: disruption of the menstrual cycle, anovulation, delayed release of the egg.
• In the countries of the European Union, Utrogectan is prohibited for oral use. It is believed that its vaginal use does not interfere with the functioning of the gastrointestinal tract and liver.
• Recently, the term “progesterone (morning) children” has been heard. This is the name given to babies born thanks to taking the medicine “Utrogectan”. Some doctors prescribe it to healthy women as a safety net, although the body itself produces hormones in the required quantities. Therefore, if all hormonal levels are normal, the reason for prescribing additional medications should be clarified.

How is drug withdrawal carried out?

Cancellation of Utrozhestan should be carried out according to a certain scheme. If the hormone is canceled incorrectly, a woman may experience some hormonal imbalances. Most often, one of two schemes is used:

• Reduce the dosage of the medication by 100 ml every 7 days.
• Reduce the dosage by 50 ml every three days.

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During this period, the expectant mother should regularly visit the doctor and undergo all necessary tests. This helps to monitor the condition of her blood and the body as a whole.

Action and release form

to guarantee the further development of the fetus
The threat of miscarriage often occurs due to insufficient progesterone in the female body.

The medication is designed in such a way that it contains the active substance – natural progesterone.

Proper use of the medicine allows the main component to safely penetrate the nucleus of the egg and carry out the process of RNA formation.

If you use the drug during the period of conception, the medicine has a positive effect on the reproductive system

women. This is revealed in the fact that a favorable environment is formed for the development of an embryo from the egg upon penetration of the sperm.

Using the drug on your own is strictly prohibited. We must not forget that such self-medication can harm a woman’s health. The doctor recommends it according to indications, and strictly prescribes the duration and frequency of use of the drug.

The medicine is available in the form of capsules

, but with different volumes of active substance - 100 and 200 mg. The question arises: is it possible to drink Utrozhestan, or should it be used in another way.

The drug is administered in different ways:

• orally;
• vaginally.

Both methods of application do their job perfectly, but in some situations it is recommended to follow the advice of your doctor. There are the following reasons for this:

1. When the drug is administered orally in the digestive organs, a small part of the active substance is subject to destruction
   , which as a result does not give the expected result.
2. When the capsule is inserted vaginally, the active ingredient reaches the desired organ faster, which stimulates an immediate effect.
3. When using the medicine for insertion through the vagina, a significantly smaller volume of the drug is required to obtain the desired result.

The doctor knows best the effects of the drug, so you must strictly follow his recommendations.

Pharmacological action of the drug

Why is the drug prescribed during pregnancy at different stages? During pregnancy, women usually use vaginal administration of the medication. For this, special candles are used. This type of treatment is carried out among expectant mothers for the following conditions:

• The woman is at risk of miscarriage or spontaneous abortion.
• Insufficient level of progesterone in the body.
• History of termination of pregnancy due to progesterone deficiency.

If a girl has previously had miscarriages, Progesterone can be prescribed by a specialist as a preventive measure. Utrozhestan is used as an emergency if there is a threat of miscarriage.

In addition, the remedy in question is often used in the following situations:

• Miscarriages during previous pregnancies.
• Various complications during pregnancy due to progesterone deficiency.
• Fertilization was done through IVF or this method was used in the past.
• The girl's previous pregnancy ended in premature birth.
• The development of infertility against the background of menstrual cycle disorders, namely its second phase.
• Isthmic-cervical insufficiency.

The above indications are just a few items from the entire list. Utrozhestan can be prescribed by a doctor to a patient for other disorders. The product is often used, for example, when planning a baby to normalize hormonal levels.

Indications for use

This occurs due to the effect of the active substance on the follicular hormone

.

After fertilization occurs, the main component contributes to the emergence of a condition that is necessary for the normal formation of a fertilized egg.

There are certain situations in which the use of the drug is mandatory:

• infertility;
• prerequisites for premature delivery at the onset of the 20th week and beyond;
• fibrocystic mastopathy;
• preventive measures in case of threat of unintentional miscarriage in the initial stages of embryo development.

Capsules can be administered either orally or intravaginally

. This method of influencing the body is necessary for developing menopause, as well as as a preventive measure for the development of uterine fibroids, premature menopause and endometriosis.

Before starting use, it is recommended to find out what kind of drug Utrozhestan is and why it is taken. The main function of the drug when it enters the body is to reduce tone, reduce excitability and neutralize the contractility of the internal muscles of the uterus

and her pipes.

Important! Additionally, the active component helps to increase the urge to go to the bathroom and empty the bladder. Increases the volume of fat deposits in the female body, which undergoes significant changes during the period of bearing a child. In addition to the main direction of action of the active component, the medicine has the following effects on the body of a pregnant woman:

In addition to the main direction of action of the active component, the medicine has the following effects on the body of a pregnant woman:

1. Stimulates the formation of soft tissues during the smooth transition of pregnancy into the 2nd and 3rd trimester.
2. Helps suppress re-ovulation.
3. Neutralizes the production of specific components in the hypothalamus. Such components stimulate the process of releasing a certain hormone of a specific nature.
4. Increases the amount of glucose released by cells.
5. The formation of the end elements of the mammary gland is stimulated, the swelling of the latter and the production of milk in the postpartum period are stimulated.

Utrozhestan in the early stages

reduce the likelihood of miscarriage
In the first trimester, it is recommended to influence the body through the introduction of suppositories. They must be placed at the same time before bedtime.

This type of medication administration is most preferable for a woman in an interesting position.

In this case, the active substance causes less negative effects and poor health.

Why the drug is prescribed in the first months of pregnancy can be found out from the following list:

• to normalize well-being;
• to calm the excited nervous system;
• to reduce uterine tone.

Utrozhestan does not cause side effects during early pregnancy and is well tolerated by women. Due to the fact that the drug is developed on a plant basis, it is not able to take part in lipid or carbohydrate metabolism.

The product does not stimulate the occurrence of edema

and does not harm the child. This is evidenced by a significant number of children born after taking the drug.

Utrozhestan for the threat of premature birth

If a condition preceding premature birth develops, it is recommended to take Utrozhestan only by mouth, as a pill. But if the pregnant woman is worried about severe drowsiness, unreasonable fatigue, or there are serious problems with the functioning of the liver

, then the product must be administered in the standard way - through the vagina.

This method can only be used in extreme situations, if there is no other way to use it.

What dosage is determined only by the gynecologist based on the current situation. It is better to follow your doctor's recommendations.

Otherwise, refusal of Utrozhestan if there is a threat of premature birth threatens to lead to disastrous results

.

The role of the hormone

This hormone performs the most important functions; in the female body it is produced:

• in the adrenal glands;
• in certain structures of the brain;
• During pregnancy, the synthesis of the hormone increases tens of times; in the early stages it is produced by the corpus luteum, and in the second trimester (starting from the 16th week) and in later stages, the placenta “takes over” the function of producing the hormone.

Normally, the amount of progesterone is determined by the phase of the cycle. During the follicular phase there is little of it, but after the onset of the ovulatory phase its amount increases, and the maximum amount of the hormone is produced during the release of the egg.

If conception occurs, the level of the hormone increases tenfold. Growth continues all the time, the level begins to decrease only before childbirth. With a lack of progesterone, the likelihood of pregnancy does not decrease, and the risk of spontaneous abortion also increases.

Main indications for use

The pharmacological properties of the drug are aimed at quickly eliminating the causes of infertility. And these are:

• Disruption of the endocrine system (endocrine infertility);
• Fibromatosis;
• Cystic mastopathy;
• Insufficient production of progesterone.

In such cases, it is recommended to take the drug orally in capsule form.

• Prevention of miscarriage (if indicated);
• To restore menstruation (if the menstrual cycle is disrupted);
• Endocrine system disorders.

In such cases, vaginal suppositories are prescribed.

These are very serious diseases that are a serious problem in conception. It is taking Utrozhestan that will help get rid of ailments that prevent a long-awaited pregnancy. But it is worth understanding that only a doctor can prescribe the drug, taking into account the individual characteristics of the female body.

Utrozhestan tablets

If there is a deficiency of progesterone, doctors prescribe tablets containing a synthetic and natural analogue of this hormone. Utrozhestan belongs to the last group of drugs. It will cope with progesterone deficiency in the shortest possible time. Utrozhestan capsules are suitable for intravaginal and oral use. The medicine can also be taken during pregnancy.

Composition and release form

The drug is produced in the form of round capsules. When the tablet is opened, an oily white substance is released, which is micronized progesterone. This hormone is the main active ingredient of the drug. When interacting with the skin, the gelatin shell of the tablet begins to dissolve. The full composition of one capsule is discussed in the table below.

Components	Concentration in mg
Micronized Natural Progesterone	100
Sunflower oil	149
Soy lecithin	1
Gelatin	77
Glycerol	32
Titanium dioxide	1.6

Pharmacodynamics and pharmacokinetics

The active ingredient of the hormonal drug is plant progesterone. It has the same structure as the ovarian corpus luteum hormone. The hormone promotes the transition of the uterine mucosa into the secretory phase. After fertilization of the egg, Utrozhestan helps its further proper development. Micronized progesterone is quickly absorbed from the gastrointestinal tract. The medicine is excreted in the urine 3-4 hours after administration.

Indications for use

For infertility caused by a deficiency of the corpus luteum of the ovary, fibrocystic mastopathy, severe premenstrual syndrome, when taking estrogen during hormone replacement therapy (HRT), doctors prescribe Utrozhestan orally or intravaginally - the instructions for use contain the following recommendations for the use of tablets:

• treatment of threatened abortion with progesterone deficiency;
• treatment of luteal insufficiency for in vitro fertilization or to support natural conception;
• prevention of uterine fibroids and endometriosis;
• treatment of recurrent miscarriages due to progesterone deficiency;
• HRT for the threat of premature menopause;
• prevention of premature birth.

Useful video about the drug Utrozhestan

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Utrozhestan during pregnancy: indications and contraindications - revealing secrets about pregnancy on Pitanie4Zdravie.ru

Pregnancy makes a woman truly beautiful. But during pregnancy, many questions arise that need to be answered. Especially for you, in the “Pregnancy from A to Z” section, we publish interesting and useful articles about pregnancy, so that this wonderful time for you will be as “problem-free” and joyful as possible.

You can also find here the main signs of pregnancy, how the baby’s fetus develops at different stages of pregnancy, understand what is possible and what is not possible at different stages of pregnancy. Learn more about the effect of various foods, vitamins (for example, the effect of folic acid) on pregnancy.

What is Utrozhestan?

The product belongs to the category of sex hormones. This is a natural gestagen that can replace progesterone secreted by the female body. It is necessary for the pregnancy to proceed without deviations. The hormone is contained in the medicine in an improved form, facilitating absorption.

It changes the structure of the endometrium of the uterus so that a fertilized egg can freely penetrate into it. Reduces the risk of uterine contraction and hypertonicity, prepares the mammary glands for lactation.

The active substance of the drug is created according to a special formula, which promotes complete absorption of the drug by the mucous membranes of the vagina and stomach. When utrozhestan enters the bloodstream during pregnancy, it begins to perform the functions of the missing hormone.

The drug is involved in strengthening the endometrium, which is necessary for fixation of the fertilized egg, reduces the activity of the muscles of the uterus and fallopian tubes, preventing egg rejection, and preserves the fetus until the placenta is fully formed. Another beneficial effect of utrozhestan is the preparation of the mammary glands for lactation.

The drug has the same bioavailability for both oral and vaginal use. But candles are more effective. When they are used, progesterone enters the blood faster and reaches the endometrium. Even average doses of the drug ensure normal levels of the hormone in the body of a pregnant woman. Taking it allows the endometrium to mature and be ready for the implantation of the fertilized egg.

A gradual increase in dose in the first trimester can replace the desired level of natural progesterone. The therapeutic effect of the drug becomes noticeable after two hours if taken orally, and after an hour if used vaginally.

Advantages of Utrozhestan

The medicine is well tolerated, does not change hormonal levels, and is not addictive. When taking it, metabolic processes do not fail, causing rapid weight gain. The fetus does not experience hormonal imbalance. Utrozhestan helps not only to bear a baby, but also to conceive one. After prescribing the medicine, the condition of pregnant women becomes stable after a short period of time. The risk of miscarriage disappears.

The drug is effective for the prevention of premature birth, which may be possible due to pathologies of the cervix. It is actively used when planning pregnancy and increases the possibility of conception.

Progesterone together with estrogens are responsible for the development of the fetus. Therefore, the prescription of such hormonal drugs is necessary in some cases. Sometimes women are afraid of them, believing that their hormonal levels will be disrupted. It will not happen. And refusal of medications leads to pathologies in the formation of the fetus, contraction of the uterus, and a decrease in the rate of cell division of the embryo, which is why it will stop growing. An intrauterine infection may develop and the development of the placenta may stop.

Hormonal agents will relax the uterus, help the fetus to gain a foothold, and create a plug of mucus that prevents the penetration of infections. They will put the woman’s nervous system in order and prevent new ovulation. Therefore, if a doctor has prescribed such drugs, they must be taken exactly according to the regimen he suggested.

Read whether it is possible to fly on an airplane while pregnant, why you are in a bad mood in an interesting position, or how to give birth to a healthy baby after a frozen pregnancy.

See you soon on Anna Lyubimova's blog - mamadetochek.ru!!!

Analogues of the drug

When planning pregnancy, the drug "Utrozhestan" is often replaced with analogues. This is most often due to ease of use and intolerance to some components. Among similar products are the following: “Pragisan”, “Progestogel”, “Progesterone”, “Iprozhin” and “Duphaston”. All of these drugs may have different uses. Some of them are intended for oral administration only, others are administered intravenously or vaginally.

Many patients ask their doctor: “Which is better, Duphaston or Utrozhestan?” In fact, the effect of these remedies is the same. The only difference is that Duphaston contains synthetic progesterone and can only be used orally.

Characteristics of the drug

The only dosage form of Utrozhestan is capsules. This medication is not available in the form of gel, tablets or solutions. The main ingredient of the drug is micronized progesterone. Its dosage in each capsule is 100 or 200 mg. The amount of active ingredient affects both the shape of the capsules and the packaging.

• The drug with a dosage of 100 mg has a round shape and is sold in 28 pieces per pack (14 capsules in one blister). The drug shell is made of glycerol and gelatin with the addition of titanium dioxide. It is shiny and yellowish, and inside there is a homogeneous white oily liquid, which, in addition to progesterone, includes soy lecithin and sunflower oil.
• The drug with a dosage of 200 mg has the same composition and is also presented in pale yellow soft gelatin capsules, inside of which a whitish suspension is placed. The difference between this medicine is the shape of the capsules - they are oval. In addition, the drug is packaged in 7 capsules in one blister and sold in 14 pieces in one cardboard box.

The medication is a prescription drug, therefore it is sold in pharmacies only after presentation of a prescription, which excludes the use of the hormone for other purposes. The average price of one package, regardless of dosage, is 400 rubles. Utrozhestan should be stored at home during the entire shelf life (3 years from the date of manufacture) in a place hidden from small children. The manufacturer's recommended storage temperature is up to +25 degrees Celsius.

How to properly stop taking the drug

Specialists in the field of gynecology strongly do not recommend abruptly stopping taking hormonal medications. A decrease in progesterone in the body can lead to:

• to spontaneous abortion;
• to fading of fetal development;
• to premature birth;
• to disruption of the functioning of the genital organs.

If the need to take Utrozhestan has disappeared, then treatment can only be canceled strictly according to the regimen.

1. First of all, it is necessary to reduce the daily dosage. For example, the patient took 400 milligrams of the drug per day for a long time (200 in the morning and 200 in the evening). This means she needs to first reduce the dosage to 300 milligrams (100 in the morning and 200 in the evening), then to 200 milligrams (100 in the morning and 100 in the evening or only 200 in the evening), and then to 100 milligrams.
2. As soon as the daily norm reaches 100 milligrams, it is worth reducing the frequency of its use. That is, first you need to use it every day, then every other day, then every two days, and then completely stop it.

When stopping the drug, it is important to listen to your body. If stretching appears in the lower abdomen or lower back, it means that the level of progesterone in the body is insufficient, you need to return the previous dosage of the drug

It is necessary to reduce the daily intake of capsules or suppositories at least once every three days.

Utrogestan and ovulation

The prescribed drug raises many questions among patients planning pregnancy. For example, many are interested in how it affects ovulation and whether it suppresses it.

There is an opinion that utrozhestan blocks the maturation of the egg. To understand how well-founded the fears are, you need to understand how ovulation and morning pregnancy correlate. The female cell grows thanks to the follicle-stimulating hormone follitropin (FSH) secreted by the pituitary gland. When it fully matures, the period of production of luteinizing hormone - luteotropin (LH) begins. The surge of LH causes the follicle to burst, releasing the egg. Too much progesterone can actually block the production of luteotropin, causing ovulation to be suppressed.

However, a competent gynecologist will never prescribe utrozhestan for conception unless there are serious reasons for this. To get pregnant, it is drunk only when a woman’s ovaries and adrenal glands do not produce enough of their hormone, and it is necessary to compensate for its deficiency in the body.

From the above, we can conclude that utrozhestan suppresses ovulation only when it is taken for other purposes, when it is done by a non-professional. Or when it is drunk not in the second phase of the cycle, as recommended by the instructions, but in the first. So, if, after a thorough examination, a trusted gynecologist has prescribed you Utrozhestan to get pregnant, feel free to take it.

Drug manufacturers produce synthetic and natural progesterone substitutes. The advantage of utrozhestan is that it belongs to the latter. Among modern women there are many who became pregnant with its help, since it has a positive effect on both the development of the fetus and the well-being of the expectant mother.

Side effects and contraindications

Many women notice dizziness and severe drowsiness while taking the drug for infertility. The instructions warn about this. To avoid such discomfort, you can try changing the method of taking the tablets from oral to vaginal or taking a smaller dose. Consult your doctor!

Rarely observed side effects related to the reproductive system: blood smears or intermenstrual bleeding. There are manifestations of hypersensitivity.

Utrozhestan is contraindicated in women who have:

• Allergic reaction to components;
• Thrombophlebitis, varicose veins (only oral administration is contraindicated);
• Serious liver dysfunction (only oral administration is contraindicated);
• Malignant tumors of the reproductive organs;
• Incomplete abortion;
• Porphyria;
• Vaginal bleeding of unknown origin.

You should be careful when taking the drug if you have epilepsy, diabetes, cardiovascular disease, chronic liver failure, or bronchial asthma. More detailed information is contained in the instructions for use.

Utrozhestan substitutes

The medicine can be replaced with capsules and suppositories called Duphaston. In terms of action, this is a complete analogue of utrozhestan. It also belongs to the group of gestagens, but contains not natural, but synthetic progesterone. Otherwise, the means are no different.

Experts have different views on drugs. Duphaston has been used for a long time, its effect on the body of a pregnant woman and the fetus has been well tested and studied. The therapeutic effect is more pronounced. Therefore, when there is a threat of miscarriage, gynecologists prefer to prescribe duphaston.

Utrozhestan has recently begun to be practiced in gynecology and obstetrics. Its action has not been fully studied. Many doctors are afraid to prescribe this medicine to expectant mothers. However, duphaston is less well tolerated and often causes poor health. Utrozhestan tablets are better accepted by the body during pregnancy and do not have similar effects.

Another substitute is a medicine called Iprozhin. It also belongs to the hormonal category, has the same contents, similar effects and uses, but is cheaper. An analogue of utrozhestan is the cheaper prajisan. It is prescribed only vaginally. The medicine is available in the form of suppositories and gel.

Prajistan has fewer contraindications, but it cannot be prescribed in the early stages of pregnancy and in cases of abnormal liver function. This same group of medications includes endometrin, often used to treat infertility. Its action is similar to that of Utrozhestan, reviews of which on the forums are very positive. It costs more and is less accessible.

Contraindications to the drug

Despite the fact that Utrozhestan is an analogue of natural progesterone, its use does not always benefit the female body. There are a number of conditions when it is better to avoid artificially increasing the concentration of the hormone in the blood during pregnancy planning. The main prohibitions on taking Utrozhestan are:

• individual intolerance or allergy to the drug;
• bleeding not associated with menstruation;
• incomplete termination of pregnancy;
• varicose veins and a tendency to form blood clots;
• oncological processes and suspicions of them;
• severe disturbances in the functioning of the liver and kidneys.

It is very important that therapy with Utrozhestan takes place under the constant supervision of a doctor, especially if a woman who wants to become a mother has been diagnosed with bronchial asthma, diabetes mellitus, or has problems with the cardiovascular or nervous systems.

A specialist will be able to assess the risks of simultaneous use of an artificial hormone and drugs intended to treat the underlying disease.

In each specific case, such a combination can give a different result - the active substances can enhance or neutralize each other. Therefore, the dosage of Utrozhestan will have to be selected individually.

When to use the drug

During planning, the doctor will prescribe Utrozhestan in all cases where the previous pregnancy was terminated spontaneously. Miscarriage is one of the most common indications when it is necessary to take the drug long before conception. In addition, taking capsules will be required in the following cases:

• creating optimal conditions for conception;
• ensuring maturation of the inner surface of the uterus;
• corpus luteum support;
• conception and pregnancy resulting from IVF;
• presence of gynecological diseases;
• prevention of pregnancy complications.

Which is better - oral or topical application?

The doctor will prescribe utrozhestan in capsules, which can be used in 2 ways - taken orally or used vaginally. The second option is the most optimal, the advantages of which are the following factors:

• Vaginal use allows you to more effectively influence the ovaries;
• the level of progesterone in the blood increases gradually, acting for a longer time;
• when inserted into the vagina, the rapid effect on the uterus ensures the effective growth of the “fetal sac”;
• blood flow in the pelvic area improves;
• the muscle tone of the future fruit receptacle decreases.

If it is inconvenient or difficult to use vaginal administration, then you can take capsules in preparation for conception. However, in this case, the effectiveness is lower due to the exposure of the capsules to the aggressive environment of the gastrointestinal tract and the subsequent effect on the liver.

What doses are used?

Capsules of the drug are available in doses of 100 and 200 mg. This is an undoubted advantage of the drug: if necessary, the doctor can vary the dosage from preventive to therapeutic. For each woman using utrozhestan when planning, the doctor will select the dose individually.

Sometimes 1 capsule daily is enough for pregnancy to occur. With IVF, in order to maintain the desired pregnancy, the doctor will prescribe the maximum dosage after the artificial insemination procedure. Sometimes, in order to get pregnant, you will need to take capsules in moderate quantities.

What is the duration of treatment

The drug can be taken in long courses. The absence of pronounced side effects allows you to safely use the drug throughout the entire preparation period and from the moment pregnancy occurs.

If side effects occur when using utrozhestan capsules, you can, with the permission of your doctor, switch to another progesterone drug.

Often, the doctor will prescribe utrozhestan during planning and from the early stages after conception. Pregnancy will continue if you use the drug according to the regimen recommended by a specialist for the entire period of gestation.

The possibility of getting pregnant while taking utrozhestan increases significantly if you strictly and consistently follow your doctor’s advice. If no serious problems with reproductive health are identified at the preconception stage, then it is quite enough to start taking folate and create the conditions for conception.

Composition of the drug and its release form

The main active ingredient of the product is progesterone. It comes in micro-dosed form. In addition, the capsules contain peanut oil, soy lecithin, glycerol, gelatin and titanium dioxide.

Consumers are presented with two forms of release of this medicine: “Utrozhestan 200” and “Utrozhestan 100”. They differ from each other only in dosage. This is provided for ease of use of the medicine.

Interaction

Oral administration

Progesterone enhances the effect of diuretics, antihypertensive drugs, immunosuppressants, and anticoagulants. Reduces the lactogenic effect of oxytocin. Concomitant use with drugs that induce microsomal liver enzymes CYP3A4, such as barbiturates, antiepileptic drugs (phenytoin), rifampicin, phenylbutazone, spironolactone, griseofulvin, is accompanied by an acceleration of progesterone metabolism in the liver.

Simultaneous use of progesterone with some antibiotics (penicillins, tetracyclines) can lead to a decrease in its effectiveness due to disruption of the enterohepatic recirculation of sex hormones due to changes in the intestinal microflora.

The severity of these interactions may vary in different patients, so predicting the clinical effects of these interactions is difficult. Ketoconazole may increase the bioavailability of progesterone.

Progesterone can increase the concentration of ketoconazole and cyclosporine, reduce the effectiveness of bromocriptine, and cause a decrease in glucose tolerance, thereby increasing the need for insulin or other hypoglycemic drugs in patients with diabetes.

The bioavailability of progesterone may be reduced in patients who smoke and with excessive alcohol consumption.

Intravaginal use

The interaction of progesterone with other drugs during intravaginal use has not been assessed. The simultaneous use of other drugs used intravaginally should be avoided to avoid disruption of the release and absorption of progesterone.

When is it prescribed?

We are accustomed to the fact that Utrozhestan is almost always prescribed when there is an “interesting situation”. But if a woman has problems with the hormone that do not allow her to become pregnant, then the doctor will prescribe medications in the preparatory period for the upcoming conception.

Utrozhestan in case of threat is the most common case of using the drug. But it is also in demand during menopause, when a woman experiences a deficiency of this hormone. In this way, ladies prolong the youth of their body and feel great. But here a doctor's opinion is necessary.

The use of the drug in the early stages of an “interesting situation” is justified, but sometimes a specialist prescribes it in the 2nd trimester. However, in this case, you need to remember the need to monitor the condition of the liver. The use of the medicine is prohibited during breastfeeding.

And the whole point is that the effect of the drug during this period has been little studied. Utrozhestan 100 capsules N28 is the most popular version of the drug. It is prescribed both for oral and intravaginal administration. The instructions indicate indications for use.

And these are not only the reasons I have already indicated, but also the following:

• with premenstrual tension syndrome;
• with fibrocystic mastopathy;
• for the prevention of uterine fibroids.

And this is not the entire list of indications. The price of such a composition is not as high as it might seem. It fluctuates around 500 rubles.

Pregnancy planning. And . Utrozhestan.

And do you think it’s worth starting without a doctor’s prescription?

Is it effective?

When used correctly, everything is effective

Is it worth the bother?

go to the doctor

Well, you give it! Utrozhestan is taken with low progesterone levels - is this your situation?

Don't even know. I haven't gone to the doctor yet. I understand that this is not an excuse, but you can’t get to our G. (((

Don't even know. I haven't gone to the doctor yet. I understand that this is not an excuse, but you can’t get to our G. (((

Utrozhestan is a very good thing. I drank myself. The doctor praised me when she found out. It obviously won't do any harm. just don’t cancel abruptly)

those. taken without a doctor's prescription? Vaginally? or orally and on what days of the cycle?

obviously no harm done

By asking the question I just wanted to hear the different opinions of those who have already taken it. Some helped, some not.

Yes, you are right, I heard that it helped someone, that’s why this question arose.

I don’t think it’s worth prescribing it yourself - go see a doctor. Since this medicine suppresses ovulation, the doctor himself must schedule the days on which you need to take the morning. And also a dose too. Because Utrik is available in different capsule doses. Do not self-medicate. And good health to you.

By the way, I took Utrik vaginally.

But did you try it by guessing and using the calendar method?

you would start by having everyone examined and treating the entire chronicle, infections would be cleared up by culture.

then they did folliculometry in 2-3 cycles and even then they probably got pregnant under her control.

parallel to my husband's spermogram.

This is all easier to do than putting extra hormones into the body.

healthy women do not need additional progesterone.

I even got pregnant with half of one ovary without progesterone.

Pharmacological features of the drug

Utrozhestan is a hormonal drug that has proven itself to be a highly effective and efficient drug, even if the body does not produce it in sufficient quantities. Utrozhestan is based on the synthetic hormone progesterone, which is necessary for the attachment of a fertilized egg and the successful development of pregnancy.

How does progesterone work in a woman’s body?

• Activates the production of the corpus luteum in the required quantity, which creates favorable conditions for fertilization;
• Promotes the qualitative transition of the egg into the uterine cavity;
• Reduces muscle activity of the fallopian tubes;
• In late pregnancy, it stimulates lactation for further breastfeeding.

Utrozhestan is prescribed only after examination and thorough laboratory tests. It is not always possible for a woman to become pregnant for a long time due to a lack of hormones. There are various individual characteristics of the body that only a specialist can determine.

Utrozhestan or Crinon

Manufacturer: Fleet Laboratories, UK
Release form: vaginal gel

Active ingredient: progesterone

Crinon has the same composition as Utrozhestan and is available in the form of a vaginal gel. Used up to 12 weeks in cases of threatened miscarriage and miscarriage, amenorrhea and progesterone deficiency. The difference between the analogue is that it is inserted daily into the vagina during pregnancy or 2 times a week for other indications.

Is it possible to replace medications, which is better – Crinon or Utrozhestan for IVF? Discuss with your doctor based on your individual characteristics. The cost of the analogue is several times higher.

Analogues of the drug Utrozhestan cannot be chosen independently, without consulting a doctor. The drugs are available by prescription and have many contraindications and side effects. Unsystematic use can aggravate the disease and lead to irreparable consequences. The information on the site is provided for informational purposes only.

Compatibility with other drugs

If the expectant mother is taking any medications, this must be taken into account when prescribing Utrozhestan, because this hormonal drug can affect the effect of other medications. For example, its use will enhance the therapeutic effects of anticoagulants, diuretics or immunosuppressants. Some antibacterial agents can reduce the effectiveness of Utrozhestan, for example, tetracycline and penicillin antibiotics, which is taken into account when treating infections in expectant mothers.

The combined use of drugs vaginally deserves special attention if the capsules are also prescribed for insertion into the vagina. It is not advisable to use the medication simultaneously with any other local agents. Therefore, if the expectant mother is prescribed treatment with suppositories “Terzhinan” or “Pimafucin”, “Fluomizin”, “Hexicon”, “Papaverine” and similar drugs in the form of vaginal tablets, suppositories or creams, then there should be a break between their use and the administration of “Utrozhestan” minimum 2 hours.

Objectives of natural matter

Progesterone is called “the key to maternal instinct.” It begins to be intensively produced by the corpus luteum when a mature egg leaves the follicle. Under its influence, favorable conditions are created for fertilization and implantation of the embryo in the uterus, not only physiological, but also psycho-emotional.

In the second half of the cycle, a woman’s libido increases, she becomes more emotional and caring, and morally mature to raise and protect a child.

If conception has occurred, the placenta takes on the role of the main producer of progesterone. The constantly increasing level of this chemical ensures normal tone of the uterus, reducing the contractility of its muscle fibers, and also prepares the ducts of the mammary glands for lactation.

In a situation where the level of progesterone in the blood is insufficient, the successful onset of pregnancy and bearing a baby becomes problematic.

In addition, a woman may be bothered by:

• cysts of the reproductive organs;
• rashes;
• irritability;
• mastopathy;
• disruptions of the menstrual cycle.

Substitution medications help correct the situation.

Utrozhestan in the last trimester of pregnancy

For some patients in late pregnancy, Utozhestan is simply necessary in some cases:

• When diagnosing an underdeveloped placenta;
• If conception was carried out using IVF therapy.

At such times, intravaginal use (vaginal suppositories) is recommended. Even in the 2nd and 3rd trimester, Utrozhestan does not harm the development and growth of the baby.

Properties of the drug

Every month, an egg matures in a woman’s body. The balanced operation of all systems determines whether the planned conception will occur or whether it will be withdrawn during menstruation. After fertilization has occurred, a temporary endocrine gland, the corpus luteum, begins to mature in the ovary. Its main function is the production of progesterone until the placenta is formed, this is 15-16 weeks of pregnancy.

The main active element of Utrozhestan is natural progesterone, but with an improved formula for rapid absorption when entering the body. Many mothers do not understand why utrozhestan is prescribed during pregnancy if conception has already occurred. The main function is to compensate for the deficiency of progesterone, which affects the preservation of gestation and the normal formation of the embryo.

Utrozhestan 200 contraindications when planning pregnancy

Not everyone can take hormonal medications, since each of them has a number of contraindications:

1. Thrombosis and thrombophlebitis.
2. Malignant formations in the genitals or mammary glands.
3. Unexplained bleeding and discharge from the genitals.
4. Liver dysfunction.
5. Varicose veins
6. Diseases of the central nervous system (CNS).
7. Lactation period - breastfeeding.
8. The patient's age is less than 18 years.

In addition, if a woman has cardiovascular disease, asthma or diabetes, she should immediately inform her doctor.

In such cases, the drug should be taken with caution and under the supervision of a qualified specialist.

The drug has no serious side effects; the most common are drowsiness, lethargy, diarrhea and constipation. Therefore, it is best to take Utrozhestan at home, when you don’t have to go anywhere and you can lie down quietly.

If you take Utrozhestan in the third trimester, serious complications in the liver may occur.

Uncontrolled use of the drug can lead to another dangerous condition - an excess of progesterone, which can result in disruption of the digestive system of a pregnant woman. In this case, the fetus will not receive enough energy necessary for its development, and, as a result, it may be born underdeveloped or weakened.

Progesterone and infertility

A common cause of infertility and miscarriage is a lack of progesterone. If its level in the blood is low, the endometrium (uterine lining) remains thin and a fertilized egg cannot implant in it. To solve the problem, expectant mothers are prescribed utrozhestan. This drug is a natural analogue of progesterone.

Utrozhestan is prescribed to normalize progesterone levels in the blood. It has been proven that the amount of this hormone has a direct effect on many processes in the body of the expectant mother. To determine how effective the drug is, you need to understand how pregnancy progresses on the morning of pregnancy. The pharmacological action of micronized hormone is as follows:

• formation of a healthy endometrium, increasing its thickness;
• preparing the mucous membrane for the attachment of a fertilized egg;
• promoting implantation and further development of the embryo;
• decreased contractility of the muscles of the uterus and tubes;
• stimulation of the growth of milk alveoli and the proliferation of glandular breast tissue.

Utrozhestan - composition and action

Progesterone is the active component of the drug Utrozhestan.
It is considered the "pregnancy hormone". It is he who ensures the successful conception and gestation of a baby, and also prepares a woman’s body for childbirth and breastfeeding. The progesterone contained in the medication is identical to that produced by the corpus luteum. The effects of progesterone at different stages of gestation:

• In the first days after conception, the hormone prepares the endometrium of the uterus for blastocyst implantation. At the same time, it makes the vaginal epithelium denser and the cervical mucus thicker - subsequently it forms a plug that protects the embryo.
• When the blastocyst is implanted into the endometrium, progesterone reduces the woman's immunity so that the body does not reject the embryo as a foreign element. In addition, the contractile activity of the smooth uterine muscles decreases, which reduces the likelihood of miscarriage.
• Progesterone helps the development of the mammary glands, as well as their ducts. This is necessary for milk synthesis and the ability to breastfeed a newborn.

How to use candles correctly

To achieve the best effect, you should learn how to use candles correctly. It is important that the woman places Utrozhestan as far into the vagina as possible and close to the cervix.

To do this you need to do the following:

• wash your hands and dry them well so that the candle does not stick to them;
• lie down, bend your knees, place a pillow under your hips;
• The candle is inserted as deeply as possible.

It is advisable to lie down for at least half an hour so that the medicine is absorbed into the mucous membrane. Alternatively, sit quietly, without sudden movements. Women are often interested in which is better: Utrozhestan or Duphaston.

Despite the fact that these two drugs have fairly similar indications for use, they cannot be called analogues. However, they have different chemical compositions. Moreover, in some situations, the doctor prescribes the simultaneous use of these compounds. Still, it is better to use them in order.

Are there any contraindications for taking pills?

Like many other products, the drug "Utrozhestan" 200 and 100 cannot be used if you are hypersensitive to the components. So, if you are allergic to peanut butter or soy, you should choose an alternative treatment.

When else should you not use Utrozhestan tablets? The instructions for use say the following. Capsules are contraindicated for thrombosis of veins and arteries. Also, during an exacerbation of phlebitis, you should not take this medicine. It is strictly forbidden to use the hormone in case of incomplete abortion or bleeding from the genitals of unknown origin. You should not take capsules if you have kidney or liver failure, or if malignant tumors that are hormonally dependent are detected.

You should use the product with extreme caution if you have problems with blood vessels and the heart, during lactation, and so on. Before taking it, you should definitely consult with a specialist and undergo some examinations.