YARINA, YARINA - instructions for use of the medicine, reviews, description, price

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The abstract describes the drug as a monophasic low-dose oral combined estrogen-progestogen contraceptive drug .

Yarina acts by blocking ovulation and increasing the viscosity of cervical mucus.

In women using Yarina birth control pills, the menstrual cycle is normalized, menstrual-like painful bleeding is less common, the intensity and duration of bleeding is reduced, resulting in a reduced likelihood of iron deficiency anemia . There is evidence of a reduced risk of ovarian and endometrial .

Composition of hormones in Yarina: ethinyl estradiol and drospirenone .

Drospirenone has an antimineralocorticoid effect and is able to prevent weight gain and the appearance of other symptoms associated with deterioration of fluid excretion from the body.
Drospirenone demonstrates antiandrogenic activity and helps reduce acne and oily skin.

Pharmacokinetics

Drospirenone

When taken orally, it is quickly absorbed. The highest level in the blood is reached after about an hour and a half. Bioavailability approaches 75-85%. Eating food does not affect the bioavailability of drospirenone.

albumin in the blood and does not bind to corticosteroid-binding globulin . Only about 4% of the total content in serum is present in free form.

Completely metabolized. Transformation products are represented by acid derivatives of drospirenone , which are excreted in urine and feces in a ratio of 6/5. The half-life is approximately 40 hours.

In women with moderate liver dysfunction, pharmacokinetic parameters are comparable to those in healthy women, and the half-life of drospirenone in such patients is 1.8 times longer than in healthy individuals with normal liver function. In patients with moderate liver dysfunction, the clearance of drospirenone was reduced by half compared to healthy women.

The concentration of drospirenone in the blood at steady state in women with mild renal impairment is comparable to that in healthy women. And in women with moderate renal impairment, the content of drospirenone in the blood is 35% higher than in healthy women.

There were no fluctuations in blood potassium concentrations when using drospirenone.

Ethinyl estradiol

After consumption, ethinyl estradiol is actively absorbed. The highest level in the blood, as Wikipedia indicates, is achieved in an hour and a half. Metabolized in the liver, bioavailability is about 45%. The main transformation method is aromatic hydroxylation. Approximately 98% of the molecules of the substance are bound by albumin.

It is not excreted from the body in unchanged form. Ethinyl estradiol derivatives are excreted in urine and bile. The half-life is 24 hours.

https://youtu.be/3J1s9jijFhI

pharmachologic effect

This drug has a good contraceptive effect, which is manifested in the ability of the drug to increase the viscosity of cervical mucus and suppress the ovulation process. Thickening of the cervical mucus prevents sperm from penetrating into the uterine cavity.

Systematic use of Yarina helps reduce or completely eliminate pain during the premenstrual period, reduce the intensity of bleeding, and normalize the menstrual cycle. These contraceptive effects reduce the likelihood of iron deficiency anemia and the development of endometrial and ovarian cancer.

The combined action of ethinyl estradiol and drospirenone helps to increase HDL levels and improve the lipid profile.

Contraindications

Contraindications to the use of Yarina tablets:

current and past thrombosis and thromboembolism (including stroke, venous thrombosis, myocardial infarction, pulmonary embolism ), cerebrovascular changes;
current and past pancreatitis with hypertriglyceridemia ;
current and past pre-thrombosis conditions (including angina pectoris , ischemic attacks );
current and past migraines with neurological symptoms;
diabetes mellitus with vascular complications;
risk factors for vascular thrombosis , for example, atrial fibrillation , complicated changes in heart valves, vascular diseases of the brain or heart, surgery followed by prolonged immobilization, arterial hypertension , smoking after 35 years;
decompensated renal failure or acute renal failure;
insufficiency of liver function or severe liver disease (until normalization of tests);
current and past liver tumors;
hormone-dependent malignant tumors or suspicion of them;
bleeding from the vagina of unknown origin;
lactation;
pregnancy or suspicion of pregnancy;
hypersensitivity to the components of the drug.

If any of the above disorders develop for the first time while taking the medication, it should be discontinued immediately.

Yarina hormonal tablets should be taken with extreme caution if you have any of the following conditions or diseases:

risk factors for thrombosis: obesity , smoking , arterial hypertension, dyslipoproteinemia , extensive trauma, migraine , prolonged immobilization, heart valve defects, surgical interventions, hereditary predisposition to the development of thrombosis ;
other diseases that can provoke changes in peripheral circulation or superficial phlebitis ;
hypertriglyceridemia;
angioedema of hereditary origin;
liver diseases;
postpartum period;
diseases that arose or were complicated during pregnancy or previous use of sex hormones ( porphyria , jaundice , herpes of pregnant women, cholelithiasis, otosclerosis, Sydenham's chorea ).

Side effects

As with other combined contraceptives, side effects of Yarina such as thromboembolism or thrombosis .

Side effects of Yarina:

from the genital area: discharge from the vagina or mammary glands, pain and enlargement of the mammary glands;
from the digestive system: vomiting, abdominal pain, nausea, diarrhea ;
from the visual side: discomfort when using contact lenses;
disorders of nervous activity: deterioration of mood, mood changes, weakening or increased libido , headache , migraine ;
skin: erythema nodosum , rash, urticaria, erythema multiforme ;
from the metabolic side: weight change, water retention in the body;
other disorders: allergic reactions.

Instructions for use of Yarina (Method and dosage)

The tablets should be taken orally in order, according to the directions on the package, at the same time every day, with water.

Yarina tablets, instructions for use

The drug is taken 1 tablet per day for 3 weeks. Taking tablets from the next pack should be started after a seven-day break, with “ withdrawal bleeding ” usually developing. It begins approximately 3 days after taking the last tablet and can continue until the use of tablets from a new blister.

Start of reception

How to take Yarina for the first time?

If you have not used any hormonal contraceptives in the previous month, the use of the medicine begins on the 1st day of the menstrual cycle. It is also permissible to start using it on days 2-5 of the menstrual cycle, but in this case you need to use a barrier method of contraception in the 1st week of use.

If the patient switches from other oral combined contraceptives, a contraceptive patch or vaginal ring , then it is advisable to start using the medicine on the day following the last tablet of the “old” drug, but no later than the next day after the standard 7-day break (for products containing 21 tablets ) or after consuming the final inactive tablet (for products containing 28 tablets). When using a vaginal ring or contraceptive patch, use of the medication should begin on the day the patch or ring is removed, but no later than the day the new ring or patch is installed.

The transition from contraceptives ( mini-pills containing only gestagen ) to Yarina can be done on any day (without a temporary break). Switching from an implant containing only gestagen , or a gestagen-releasing intrauterine contraceptive - on the day of its removal. Switching from the injection form - from the day on which the following procedure should be performed. In all of the above cases, you need to use a barrier method of contraception in the 1st week of use.

After childbirth or an abortion in the second trimester, you should start taking the medicine no earlier than 4 weeks after the birth (provided that the mother is not breastfeeding) or the abortion. If use is started later, you need to use a barrier method of contraception in the 1st week of use. But if the patient has already had sexual intercourse, before starting to use Yarina, it is necessary to exclude pregnancy or wait until the 1st menstruation.

After an abortion in the 1st trimester of pregnancy, it is allowed to start taking the medication on the day of the abortion. If this condition is met, the patient does not need additional methods of contraception.

Missed pills

If the medicine was taken less than 12 hours late , contraceptive protection is not reduced. A woman needs to take the pill as quickly as possible, the next pill is taken at the usual time.

If the medicine was taken more than 12 hours late , contraceptive protection is reduced. The more pills you miss, the greater the likelihood of pregnancy. If you skip 1 tablet, the chance of getting pregnant is minimal. If you are late for more than 12 hours, follow the recommendations below.

The pass was made in the first 7 days of taking the drug

You should take the last missed tablet as soon as possible, even if you need to take 2 tablets together. The next tablet is taken at the usual time. It is recommended to use a barrier method of contraception for another week. If you had sexual intercourse within 7 days before missing a pill, you must consider the possibility of pregnancy.

The pass was made on days 8-14 of taking the drug

You should take the last missed tablet as soon as possible, even if you need to take 2 tablets together. The next tablet is taken at the usual time. If the patient has taken the pills correctly over the past 7 days, then there is no need to use additional contraceptive measures. Otherwise, or if you miss 2 or more tablets, you must additionally use barrier methods of contraception for another week.

The pass was made on days 15-21 of taking the drug

The risk of pregnancy increases due to the upcoming temporary break in taking the drug. The patient must do one of the following two options. Moreover, if the pill regimen has been followed over the last week, there is no need to use additional methods of contraception.

You should take the last missed pill as soon as possible, even if this means taking 2 pills at the same time. Subsequent tablets from the current package are consumed as usual until they run out. The next package should be used without interruption. Until the tablets from the second package run out, withdrawal bleeding is unlikely, but breakthrough bleeding and spotting while using the tablets cannot be ruled out.
You need to stop taking the tablets from the current blister and start a seven-day break, and then start taking the medicine from the new blister. If the patient has not taken the pills and has not developed withdrawal bleeding during the seven-day break, pregnancy must be excluded.

For vomiting and diarrhea

If vomiting or diarrhea within four hours after taking the tablets, they may not be completely absorbed. In such a case, additional contraceptive measures should be taken, and the above recommendations should also be followed when skipping pills.

How to change the first day of the menstrual cycle?

To postpone the 1st day of menstruation, you need to continue taking Yarina from a new package without a seven-day break and take the tablets as needed. In this case, spotting or bleeding is possible.

YARINA

encounter the drug “Yarina” and hormonal contraceptives in general. So here's my story. Let me start with the fact that when I was a teenager I started having problems with my skin. From the age of thirteen, pimples, blackheads and blackheads became my constant and faithful companions. And no matter how much I fought with them, two or three new ones invariably took the place of one defeated pimple. I looked at my peers who were spared this scourge with outright envy, especially at the age of 16-17, when acne began to disappear in those who had it. For me, there was no end in sight... Eighteen, nineteen, twenty years... And only after crossing the age line of 21, I was finally able to breathe a sigh of relief: my skin finally began to clear up. Acne gradually began to disappear and delight me with its presence only once a month, during a strictly defined period. And yet the joy did not last long. At the age of 23 they returned, but in such quantity and quality that all my previous suffering seemed to me to be harmless “little flowers”. These were no longer just pimples, but huge subcutaneous comedones. And they looked very little like their younger “brothers” - they walked all over the face, but then disappeared practically without leaving a trace. The new “friends” occupied only the cheeks, chin and neck, but did not go away for a long time and left behind ugly scars. In addition, they were unbearably sick, so much so that sometimes it was even difficult to fall asleep. At first, I tried to fight them on my own - I bought all possible and impossible masks/creams/talkers, wiped my face with calendula tincture. But if earlier these remedies could still give some result, then against comedones they turned out to be like a dead poultice. Unfortunately, I have almost no photographs left from that period - with such beauty on my face, it was painful for me to look at myself in the mirror again, not to mention taking pictures. If I took photographs, it was only from a distance, and then after combing my hair over my cheeks so that skin defects were not so noticeable. We managed to dig up only one photo, in which, when enlarged, you can still see how severely acne-damaged the skin on the chin is (the cheeks are damaged in the same way, but shyly covered with hair): Photo from ten years ago. Before receiving Yarina. As a result, tired of the useless struggle, I made an appointment with a dermatologist. She, in turn, only glanced at me briefly and sent me to take hormone tests. The test results confirmed the diagnosis of “hormonal imbalance” and showed an increase in the hormone DHEA sulfate DHEA-S (dehydroepiandrosterone sulfate) is a hormone that reflects the ability of the adrenal glands to produce male sex hormones. Both an increase and a decrease in the content of this hormone are unfavorable for health ovya. Its excess may indicate diseases of the ovaries and adrenal glands, and its deficiency may indicate diabetes or inflammatory processes in the kidney area. The dermatologist explained that my problems with skin and hair (in addition to “vulgar” acne, I was also worried about active hair loss) are associated precisely with the increased production of this very notorious hormone in the body and will not be solved just like that. You can get rid of them only by taking hormonal contraceptives. And she prescribed Yarina, which I had to take for at least three months. Yarina is a low-dose monophasic oral combined estrogen-progestogen contraceptive drug. Yarina's contraceptive effect is carried out through complementary mechanisms, the most important of which include suppression of ovulation and changes in the properties of cervical secretion, as a result of which it becomes impenetrable to sperm. In women taking combined oral contraceptives, the cycle becomes more regular, painful menstrual-like bleeding is less common, the intensity and duration of bleeding decreases, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduced risk of endometrial and ovarian cancer. Drospirenone contained in Yarin has an antimineralocorticoid effect and is able to prevent weight gain and the appearance of other symptoms (for example, edema) associated with estrogen-dependent fluid retention. Drospirenone also has antiandrogenic activity and helps reduce acne (blackheads), oily skin and hair. At that time, I didn’t think about it, but after that I constantly asked myself - how could she prescribe me hormones based on just a blood test? Why didn’t she additionally send you for an ultrasound, for a more detailed examination to other specialists - an endocrinologist, a gynecologist, a urologist in the end? Why, instead of finding the root cause of hormonal imbalance, did you decide to eliminate only its external manifestations? All these questions remain unanswered. And then I didn’t have them, because I was used to taking doctors at their word. And I didn’t have the Internet at hand; I got it much later. But there was a pharmacy nearby, and in the pharmacy there was “Yarina”... Price. At that time, the drug, although it was slightly more expensive than its analogues, did not hurt the wallet too much - its cost was about 500 - 550 rubles per blister. Over time, the price began to rise: first to 600, then to 700 rubles. At some point it jumped up to 1000, but then dropped again to 900. For this amount I bought it for the last time. Now, as far as I know, Yarina has risen in price again. So if you plan to constantly “sit” on Yarin, then be prepared that for this “pleasure” you will need to pay about 12,000 rubles a year. Composition: 1 tablet ethinyl estradiol - 30 mcg drospirenone - 3 mg Excipients: lactose monohydrate - 48.17 mg, corn starch - 14.4 mg, pregelatinized corn starch - 9.6 mg, povidone K25 - 4 mg, magnesium stearate - 800 mcg. Shell composition: hypromellose (hydroxypropyl methylcellulose) - 1.0112 mg, macrogol 6000 - 202.4 mcg, talc (magnesium hydrosilicate) - 202.4 mcg, titanium dioxide (E171) - 556.5 mcg, iron (II) oxide (E172) - 27.5 mcg. Release form. At the pharmacy you can buy Yarina either in a box or in a separate blister. One box is designed for three months of use - it includes three blisters, instructions for use and a cardboard protective case for tablets. However, due to the high cost - for a three-month course you will have to pay about 3,000 rubles - few people buy the entire box at once. Therefore, “Yarina” is sold mainly in one blister pack. But you may not get the instructions and protective case - only if the pharmacist is in a good mood that day. On the day when I made my last purchase of this drug, I was in an average lousy mood, so you will see photos of the instructions, but, unfortunately, no photo of the case. Contraceptives Schering AG Yarina. Instructions Contraceptives Schering AG Yarina. Side effects. Contraceptives Schering AG Yarina. Side effects. The Yarina tablets themselves are small in size, I would say even miniature. This, of course, is very convenient - such tablets are much easier to swallow and they will not get stuck in the throat. They are covered with a light yellow shell with the combination of letters DO embossed on them. Contraceptives Schering AG Yarina How to take. Like any other oral contraceptives, there is a dosage calendar behind the blister. One day - one tablet. So, if you start taking OK on Monday, then take a pill labeled PN, and then move along the arrow in accordance with the day of the week until all the pills are gone. It is necessary to use OK every day, strictly at the same time. Just one course is 21 days (21 tablets). Then you should take a seven-day break, during which menstruation should begin. In fact, this will not be real menstruation, but “Yarina’s bleeding.” At first, taking hormonal contraceptives was scary for me - scary stories about “increased hairiness” and sudden weight gain after starting to take them made themselves felt. But I was so driven to despair that I was ready to drink anything just to restore my face, if not beauty, then at least a more or less decent appearance. And finally I made up my mind. I took a three-month course and... nothing happened. I didn’t grow a beard, and I didn’t have any fat on my sides or thighs. It’s true that acne, contrary to expectations, has not disappeared anywhere. Not in three months, not in six months, not in a year. But I, with manic persistence, still continued to swallow Yarina, especially since the contraceptive effect from it brought me complete delight. Of course - now there was no need to shake every month before the start of menstruation, worrying about whether they would start or not - they now always came consistently at the same time - on the second day after the end of the next package. And no unwanted pregnancy! And after a year and a half, the first aesthetic result finally began to appear - there were significantly fewer new pimples on the face, and traces of old ones could now be safely “killed” with scrubs and peels, without fear of damaging inflamed comedones. Because I almost no longer had inflamed comedones. The hair loss also stopped and, to my delight, I noticed that the hair on my head had become much thicker. But the “antennae” above the upper lip, on the contrary, disappeared. It would seem that now the goal has been achieved and the experiment with hormones can be stopped. However, this was not the case. It turned out that once you get hooked on hormones, it’s not so easy to get off them. As soon as I took a break of several months (and such breaks must be taken periodically), all the skin problems gradually returned. Yes, they didn’t just come back, but almost double the size and the comedones looked even worse than they were before the first use of Yarina. And again I ran to the pharmacy in panic, and again frantically swallowed another pack of pills. And so on endlessly...2014. Five years on Yarina. New acne appears only during the withdrawal period. Thanks to scrubs and peelings, the skin has become significantly smoother. First side effect. Years passed. “Yarina” had already become such a strong part of my life that I simply couldn’t imagine how I could live without her before. The skin became, if not perfect, then at least completely cleansed. Periodic visits to the gynecologist's office only instilled confidence that my commitment to OK was an extremely noble cause. Gynecologists, both from paid and free clinics, did not find any abnormalities in my reproductive system, unanimously praised me for such careful attitude towards my health and advised me to continue drinking “Yarina” in the future. However, every year the concern grew more and more - what to do with Yarina next? Age is steadily moving toward thirty, I need to somehow take care of procreation, but I still can’t stop taking hormonal contraceptives. And in the sixth year of taking it, a surprise awaited me in the form of the first side effect. Suddenly, out of the blue, my libido disappeared. At all. At all. This also did not happen all at once - at first I stopped experiencing orgasm, and then, gradually, I completely cooled down to such a pleasant and previously very exciting process. At that time, I associated this with a crisis in the relationship and did not attach much importance to it. And it was very, very in vain... After all, it was just the first bell... 2015. Six years on Yarina. Shortly before the last use. The face has completely cleared up. Side effect number two. How I parted with “Yarina” forever. So I probably would have spent the rest of my life on hormones if, in the seventh year of taking it, a new emergency had not happened - intermenstrual bleeding began. Like all other side effects - also gradually. For a couple of months it was just a small smudge between periods. Then menstruation began in full for the second time in a month, although I did not stop taking the pills and the “bleeding oYarina” menstruation very quickly stabilized, and the acne, to the extent it was before, no longer returned. Acne became completely ordinary and appeared only once a month, or as a reaction to an unsuccessful face cream or toner. It would seem that the story with OK is over and it did not bring any serious consequences for the body. The third side effect is fatal. A year after abandoning Yarina. And I certainly could not have expected that Yarina would deal me another fatal blow, but later, almost a year after stopping taking it. In the spring of 2017, I had an ultrasound of the abdominal organs. It was then that a real shock overtook me when the cheerful and sociable ultrasound doctor, looking at the monitor, suddenly stopped, turned pale and after a minute pause asked if I knew that I had a tumor in my kidney. There is also a cyst on the liver, only much smaller in size. And the next six months are in a blur - computed tomography with contrast, hospitalization, surgery, three days in intensive care, difficult rehabilitation... And the histology result, which made me speechless, because doctors do not announce such diagnoses to patients in advance: Histology results. My kidney was completely removed. Luckily, on time. The tumor has not yet metastasized. What does “Yarina” have to do with her? Yes, the most direct. Hormones can trigger the development of tumors and this is exactly what happened in my case. Most likely, I had some problems with my kidney before I was prescribed Yarina (hence the acne as a reaction), but the dermatologist did not bother to send me for a full examination and prescribed a drug that only muffled the external manifestations and contributed to the appearance of the tumor in the kidney and its degeneration. And a cyst on the liver is one of the traditional side effects of Yarina, and this is written in black and white in the instructions. Contraceptives Schering AG Yarina. Side effects. I did not write this review to scare you. This review is a warning. The body is a very delicate and fragile thing, and any intervention in the processes occurring in it can have very serious consequences. No, not everyone can develop cancer after taking Yarina. Everyone's body is different and it reacts to this crap in different ways. But interference in hormonal processes does not occur in anyone without leaving a trace on the body. Even if now it seems that everything is good and wonderful, no one can give you a guarantee that it will always be this way, that side effects will not appear after many years. I also thought that “Yarina” was perfect for me, and for seven years in a row I sang her praises. It all ended very sadly. And I was lucky - thanks to the fact that the tumor was detected on time, I was able to save my life. And even without chemotherapy and radiation therapy - with the type of oncology that I had, such treatment methods are not used in the early stages. Within six months after the operation, I managed to return to a normal (or almost normal, as far as possible with a single kidney) life and return to work. Moreover, doctors say that pregnancy is not a taboo for me either; three years after the operation, it is quite possible, although under the strict supervision of doctors. And yet, I wouldn’t wish the nightmare I went through on anyone. So if you do not have any medical need to drink Yarina, you should not do it. Well, if you can’t do without it, don’t forget to regularly undergo a full examination. This is the only way to maintain your health and prevent the most severe consequences.

Before I tell you my more than seven-year history of relationship with oral contraceptives "Yarina", I would like to warn all the girls in advance - if you plan to use them solely as a means of preventing unwanted pregnancy, then it is better for you to choose another, more gentle method. I myself have never been against a barrier method of contraception and would never have switched to pills in my life if circumstances had not forced me to do so. Moreover, if it were possible to turn back time, then even the doctors’ testimony would not have forced me to swallow this muck. I would try to find other, alternative methods of treatment or other, more competent doctors. But, unfortunately, it is now too late to talk about this; we can only warn those who have not yet been lucky enough to encounter the drug “Yarina” and hormonal contraceptives in general. So here's my story. Let me start with the fact that when I was a teenager I started having problems with my skin. From the age of thirteen, pimples, blackheads and blackheads became my constant and faithful companions. And no matter how much I fought with them, two or three new ones invariably took the place of one defeated pimple. I looked at my peers who were spared this scourge with outright envy, especially at the age of 16-17, when acne began to disappear in those who had it. For me, there was no end in sight... Eighteen, nineteen, twenty years... And only after crossing the age line of 21, I was finally able to breathe a sigh of relief: my skin finally began to clear up. Acne gradually began to disappear and delight me with its presence only once a month, during a strictly defined period. And yet the joy did not last long. At the age of 23 they returned, but in such quantity and quality that all my previous suffering seemed to me to be harmless “little flowers”. These were no longer just pimples, but huge subcutaneous comedones. And they looked very little like their younger “brothers” - they walked all over the face, but then disappeared practically without leaving a trace. The new “friends” occupied only the cheeks, chin and neck, but did not go away for a long time and left behind ugly scars. In addition, they were unbearably sick, so much so that sometimes it was even difficult to fall asleep. At first, I tried to fight them on my own - I bought all possible and impossible masks/creams/talkers, wiped my face with calendula tincture. But if earlier these remedies could still give some result, then against comedones they turned out to be like a dead poultice. Unfortunately, I have almost no photographs left from that period - with such beauty on my face, it was painful for me to look at myself in the mirror again, not to mention taking pictures. If I took photographs, it was only from a distance, and then after combing my hair over my cheeks so that skin defects were not so noticeable. We managed to dig up only one photo, in which, when enlarged, you can still see how severely acne-damaged the skin on the chin is (the cheeks are damaged in the same way, but shyly covered with hair): Photo from ten years ago. Before receiving Yarina. As a result, tired of the useless struggle, I made an appointment with a dermatologist. She, in turn, only glanced at me briefly and sent me to take hormone tests. The test results confirmed the diagnosis of “hormonal imbalance” and showed an increase in the hormone DHEA sulfate DHEA-S (dehydroepiandrosterone sulfate) is a hormone that reflects the ability of the adrenal glands to produce male sex hormones. Both an increase and a decrease in the content of this hormone are unfavorable for health ovya. Its excess may indicate diseases of the ovaries and adrenal glands, and its deficiency may indicate diabetes or inflammatory processes in the kidney area. The dermatologist explained that my problems with skin and hair (in addition to “vulgar” acne, I was also worried about active hair loss) are associated precisely with the increased production of this very notorious hormone in the body and will not be solved just like that. You can get rid of them only by taking hormonal contraceptives. And she prescribed Yarina, which I had to take for at least three months. Yarina is a low-dose monophasic oral combined estrogen-progestogen contraceptive drug. Yarina's contraceptive effect is carried out through complementary mechanisms, the most important of which include suppression of ovulation and changes in the properties of cervical secretion, as a result of which it becomes impenetrable to sperm. In women taking combined oral contraceptives, the cycle becomes more regular, painful menstrual-like bleeding is less common, the intensity and duration of bleeding decreases, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduced risk of endometrial and ovarian cancer. Drospirenone contained in Yarin has an antimineralocorticoid effect and is able to prevent weight gain and the appearance of other symptoms (for example, edema) associated with estrogen-dependent fluid retention. Drospirenone also has antiandrogenic activity and helps reduce acne (blackheads), oily skin and hair. At that time, I didn’t think about it, but after that I constantly asked myself - how could she prescribe me hormones based on just a blood test? Why didn’t she additionally send you for an ultrasound, for a more detailed examination to other specialists - an endocrinologist, a gynecologist, a urologist in the end? Why, instead of finding the root cause of hormonal imbalance, did you decide to eliminate only its external manifestations? All these questions remain unanswered. And then I didn’t have them, because I was used to taking doctors at their word. And I didn’t have the Internet at hand; I got it much later. But there was a pharmacy nearby, and in the pharmacy there was “Yarina”... Price. At that time, the drug, although it was slightly more expensive than its analogues, did not hurt the wallet too much - its cost was about 500 - 550 rubles per blister. Over time, the price began to rise: first to 600, then to 700 rubles. At some point it jumped up to 1000, but then dropped again to 900. For this amount I bought it for the last time. Now, as far as I know, Yarina has risen in price again. So if you plan to constantly “sit” on Yarin, then be prepared that for this “pleasure” you will need to pay about 12,000 rubles a year. Composition: 1 tablet ethinyl estradiol - 30 mcg drospirenone - 3 mg Excipients: lactose monohydrate - 48.17 mg, corn starch - 14.4 mg, pregelatinized corn starch - 9.6 mg, povidone K25 - 4 mg, magnesium stearate - 800 mcg. Shell composition: hypromellose (hydroxypropyl methylcellulose) - 1.0112 mg, macrogol 6000 - 202.4 mcg, talc (magnesium hydrosilicate) - 202.4 mcg, titanium dioxide (E171) - 556.5 mcg, iron (II) oxide (E172) - 27.5 mcg. Release form. At the pharmacy you can buy Yarina either in a box or in a separate blister. One box is designed for three months of use - it includes three blisters, instructions for use and a cardboard protective case for tablets. However, due to the high cost - for a three-month course you will have to pay about 3,000 rubles - few people buy the entire box at once. Therefore, “Yarina” is sold mainly in one blister pack. But you may not get the instructions and protective case - only if the pharmacist is in a good mood that day. On the day when I made my last purchase of this drug, I was in an average lousy mood, so you will see photos of the instructions, but, unfortunately, no photo of the case. Contraceptives Schering AG Yarina. Instructions Contraceptives Schering AG Yarina. Side effects. Contraceptives Schering AG Yarina. Side effects. The Yarina tablets themselves are small in size, I would say even miniature. This, of course, is very convenient - such tablets are much easier to swallow and they will not get stuck in the throat. They are covered with a light yellow shell with the combination of letters DO embossed on them. Contraceptives Schering AG Yarina How to take. Like any other oral contraceptives, there is a dosage calendar behind the blister. One day - one tablet. So, if you start taking OK on Monday, then take a pill labeled PN, and then move along the arrow in accordance with the day of the week until all the pills are gone. It is necessary to use OK every day, strictly at the same time. Just one course is 21 days (21 tablets). Then you should take a seven-day break, during which menstruation should begin. In fact, this will not be real menstruation, but “Yarina’s bleeding.” At first, taking hormonal contraceptives was scary for me - scary stories about “increased hairiness” and sudden weight gain after starting to take them made themselves felt. But I was so driven to despair that I was ready to drink anything just to restore my face, if not beauty, then at least a more or less decent appearance. And finally I made up my mind. I took a three-month course and... nothing happened. I didn’t grow a beard, and I didn’t have any fat on my sides or thighs. It’s true that acne, contrary to expectations, has not disappeared anywhere. Not in three months, not in six months, not in a year. But I, with manic persistence, still continued to swallow Yarina, especially since the contraceptive effect from it brought me complete delight. Of course - now there was no need to shake every month before the start of menstruation, worrying about whether they would start or not - they now always came consistently at the same time - on the second day after the end of the next package. And no unwanted pregnancy! And after a year and a half, the first aesthetic result finally began to appear - there were significantly fewer new pimples on the face, and traces of old ones could now be safely “killed” with scrubs and peels, without fear of damaging inflamed comedones. Because I almost no longer had inflamed comedones. The hair loss also stopped and, to my delight, I noticed that the hair on my head had become much thicker. But the “antennae” above the upper lip, on the contrary, disappeared. It would seem that now the goal has been achieved and the experiment with hormones can be stopped. However, this was not the case. It turned out that once you get hooked on hormones, it’s not so easy to get off them. As soon as I took a break of several months (and such breaks must be taken periodically), all the skin problems gradually returned. Yes, they didn’t just come back, but almost double the size and the comedones looked even worse than they were before the first use of Yarina. And again I ran to the pharmacy in panic, and again frantically swallowed another pack of pills. And so on endlessly...2014. Five years on Yarina. New acne appears only during the withdrawal period. Thanks to scrubs and peels, the skin has become significantly smoother. First side effect. Years passed. “Yarina” had already become such a strong part of my life that I simply couldn’t imagine how I could live without her before. The skin became, if not perfect, then at least completely cleansed. Periodic visits to the gynecologist's office only instilled confidence that my commitment to OK was an extremely noble cause. Gynecologists, both from paid and free clinics, did not find any abnormalities in my reproductive system, unanimously praised me for such careful attitude towards my health and advised me to continue drinking “Yarina” in the future. However, every year the concern grew more and more - what to do with Yarina next? Age is steadily moving toward thirty, I need to somehow take care of procreation, but I still can’t stop taking hormonal contraceptives. And in the sixth year of taking it, a surprise awaited me in the form of the first side effect. Suddenly, out of the blue, my libido disappeared. At all. At all. This also did not happen all at once - at first I stopped experiencing orgasm, and then, gradually, I completely cooled down to such a pleasant and previously very exciting process. At that time, I associated this with a crisis in the relationship and did not attach much importance to it. And it was very, very in vain... After all, it was just the first bell... 2015. Six years on Yarina. Shortly before the last use. The face has completely cleared up. Side effect number two. How I parted with “Yarina” forever. So I probably would have spent the rest of my life on hormones if, in the seventh year of taking it, a new emergency had not happened - intermenstrual bleeding began. Like all other side effects - also gradually. For a couple of months it was just a small daub between periods. Then menstruation began in full for the second time in a month, although I did not stop taking the pills and the “bleeding oYarina” menstruation very quickly stabilized, and the acne, to the extent it was before, no longer returned. Acne became completely ordinary and appeared only once a month, or as a reaction to an unsuccessful face cream or toner. It would seem that the story with OK is over and it did not bring any serious consequences for the body. The third side effect is fatal. A year after abandoning Yarina. And I certainly could not have expected that Yarina would deal me another fatal blow, but later, almost a year after stopping taking it. In the spring of 2017, I had an ultrasound of the abdominal organs. It was then that a real shock overtook me when the cheerful and sociable ultrasound doctor, looking at the monitor, suddenly stopped, turned pale and after a minute pause asked if I knew that I had a tumor in my kidney. There is also a cyst on the liver, only much smaller in size. And the next six months are in a blur - computed tomography with contrast, hospitalization, surgery, three days in intensive care, difficult rehabilitation... And the histology result, which made me speechless, because doctors do not announce such diagnoses to patients in advance: Histology results. My kidney was completely removed. Luckily, on time. The tumor has not yet metastasized. What does “Yarina” have to do with her? Yes, the most direct. Hormones can trigger the development of tumors and this is exactly what happened in my case. Most likely, I had some problems with my kidney before I was prescribed Yarina (hence the acne as a reaction), but the dermatologist did not bother to send me for a full examination and prescribed a drug that only muffled the external manifestations and contributed to the appearance of the tumor in the kidney and its degeneration. And a cyst on the liver is one of the traditional side effects of Yarina, and this is written in black and white in the instructions. Contraceptives Schering AG Yarina. Side effects. I did not write this review to scare you. This review is a warning. The body is a very delicate and fragile thing, and any intervention in the processes occurring in it can have very serious consequences. No, not everyone can develop cancer after taking Yarina. Everyone's body is different and it reacts to this crap in different ways. But interference in hormonal processes does not occur in anyone without leaving a trace on the body. Even if now it seems that everything is good and wonderful, no one can give you a guarantee that it will always be this way, that side effects will not appear after many years. I also thought that “Yarina” was perfect for me, and for seven years in a row I sang her praises. It all ended very sadly. And I was lucky - thanks to the fact that the tumor was detected on time, I was able to save my life. And even without chemotherapy and radiation therapy - with the type of oncology that I had, such treatment methods are not used in the early stages. Within six months after the operation, I managed to return to a normal (or almost normal, as far as possible with a single kidney) life and return to work. Moreover, doctors say that pregnancy is not a taboo for me either; three years after the operation, it is quite possible, although under the strict supervision of doctors. And yet, I wouldn’t wish the nightmare I went through on anyone. So if you do not have any medical need to drink Yarina, you should not do it. Well, if you can’t do without it, don’t forget to regularly undergo a full examination. This is the only way to maintain your health and prevent the most severe consequences.

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Interaction

The use of drugs that stimulate the work of hepatic microsomal enzymes may cause an increase in the excretion of sex hormones , which causes breakthrough bleeding or weakening the reliability of contraception. These drugs include Phenytoin, Primidone, barbiturates, Rifampicin, Carbamazepine, Rifabutin and others.

Penicillins and tetracycline can reduce the enterohepatic circulation of estrogen , thereby reducing the concentration of ethinyl estradiol . During the period of use of drugs that affect microsomal enzymes , and for about a month after completion of their use, barrier contraception should be used.

Combined contraceptives may change the metabolism of other drugs, causing their concentrations in the blood and tissues to increase or decrease.

Drug interactions

When combining the Yarina contraceptive with sleeping pills, St. John's wort, Rifampicin, Carbamazepine, Griseofulvin, it is necessary to additionally use barrier methods of protection. These medications increase the clearance of hormones by accelerating the induction of liver enzymes. HIV and hepatitis C protease inhibitors can have a clinically significant effect on the concentration of estrogens and progesterones, therefore such drugs are not recommended to be used simultaneously with Yarina Plus.

Most antibiotics can reduce ethinyl estradiol levels. If antibacterial drugs are used together with a contraceptive, additional external methods should be used to prevent unwanted pregnancy. Such measures must be carried out during the course of antibiotics and for a week after completion of treatment. Yarina can affect the metabolism of antiepileptic drugs, so their combined use is not recommended.

special instructions

Before starting or resuming use of the drug, you need to familiarize yourself with your personal and family history, conduct a gynecological and general medical examination, and exclude the presence of pregnancy. The structure and scope of research, as well as the regularity of examinations, are determined in each individual case individually. Standard follow-up examinations must be carried out at least once a year.

The patient should be informed that the drug does not protect against HIV infection and other sexually transmitted diseases.

A relationship has been established between taking combined contraceptives and an increase in the incidence of vascular thrombosis and thromboembolism, including pulmonary artery thrombosis , venous thrombosis, myocardial infarction , and cerebrovascular disorders.

The risk of venous thromboembolism is highest in the 1st year of taking such drugs. An increased risk occurs after initial use of oral contraceptives or resumption of their use.

Arterial thromboembolism , the risk of which also increases when taking drugs like Yarina, can lead to vascular occlusion, stroke or heart attack . Signs of a stroke: weakness or loss of sensation in the face or limbs, problems with speech and its understanding, confusion, sudden loss of vision, dizziness, gait disturbance, causeless headache, loss of balance, loss of consciousness. Other signs of vascular occlusion: swelling, sudden pain, blue discoloration of the limbs, sharp pain in the abdomen.

Signs of a heart attack : heaviness, discomfort, pain, pressure, feeling of tightness in the arm or chest; discomfort radiating to the cheekbone, back, arm, larynx, stomach; nausea, cold sweat, vomiting or dizziness, anxiety, weakness, shortness of breath , tachycardia .

Arterial thromboembolism can be fatal.

The risk of thrombosis and thromboembolism increases:

in smokers;
with age;
for obesity;
close relatives or parents have ever had thromboembolism
with prolonged immobilization, surgery, operations on the lower extremities (in these situations, it is advisable to stop the use of combined contraceptives and not resume it for 15 days after completion of immobilization);
for arterial hypertension ;
for dyslipoproteinemia ;
for diseases of the heart valves;
for migraines ;
with atrial fibrillation .

An increase in the frequency and severity of migraine during the use of combined contraceptives may be grounds for stopping their use.

The appearance of benign liver tumors has rarely been observed during the use of combined contraceptives, and malignant tumors have been observed extremely rarely.

In patients with hypertriglyceridemia, it is possible that there is an increased likelihood of developing pancreatitis when taking medications like Yarina.

In women with hereditary angioedema, exogenous estrogens can cause or worsen the course of this disease.

While taking combined contraceptives, irregular bleeding or spotting may occur, especially during the first months of use. Therefore, assessment of irregular bleeding of any nature should be carried out only after an adaptation period of approximately 3 cycles has been completed.

If the bleeding described above recurs, then it is necessary to conduct an examination and examination to exclude malignant tumors or pregnancy.

As a consequence of withdrawal, some patients may develop bleeding when taking a break or stopping taking the pills.

Taking Yarina can change the results of a number of laboratory tests, for example, indicators of the liver, kidneys, adrenal glands, thyroid gland, the content of carrier proteins, the state of coagulation , carbohydrate metabolism and fibrinolysis .

The drug does not affect the ability to drive vehicles.

Pharmacological properties

Pharmacodynamics

Yarina Plus is a low-dose monophasic combined oral estrogen-progestogen contraceptive. Includes active and auxiliary vitamin tablets.

The effect of the drug is achieved mainly by suppressing ovulation and increasing the viscosity of cervical mucus.

When taking combined oral contraceptives (COCs), cycle regularity is achieved, reducing the duration, intensity and pain of menstrual bleeding, thereby reducing the risk of iron deficiency anemia. There is also evidence of a reduced risk of endometrial and ovarian cancer.

Drospirenone has an antimineralocorticoid effect, prevents hormone-dependent fluid retention, which can promote weight loss, and reduces the risk of developing peripheral edema. In addition, the substance has an antiandrogenic effect, reduces oily skin and hair and helps reduce acne.

Unlike folic acid, calcium levomefolate is a biologically active form of folate, making it better absorbed. The inclusion of this substance in Yarina Plus reduces the risk of developing a neural tube defect in the fetus if pregnancy occurs unexpectedly, immediately after stopping taking COCs.

Pharmacokinetics

Drospirenone is absorbed almost completely in a short period of time (absorption of the drug does not depend on food intake). The maximum concentration is reached within 1–2 hours and is 37 ng/ml. Bioavailability is in the range of 76–85%. The substance interacts with serum albumin and does not interact with sex hormone binding globulin (SHBG) or corticosteroid binding globulin (CBG). The average apparent volume of distribution is from 3.7 to 4.2 l/kg. Most of the metabolites of drospirenone are represented by its derivatives - acid forms of drospirenone, formed without the participation of the cytochrome P450 system. Drug clearance is 1.2–1.5 ml/min/kg. The decrease in plasma concentrations of drospirenone occurs in two phases, the half-life of the second phase is approximately 31 hours. The substance is not excreted unchanged. Metabolites are excreted by the kidneys and intestines within approximately 1.7 days. With regular use of Yarina Plus, the concentration of drospirenone in the blood increases 2-3 times, an equilibrium state is achieved in the second half of the cyclic treatment.

Ethinyl estradiol has rapid absorption. The maximum concentration is reached after 90 minutes. The bioavailability of the substance is reduced by 25% when ingesting food. Ethinyl estradiol actively binds to blood albumin (approximately 98%). Estimated volume of distribution is 2.8–8.6 l/kg. It is transformed in the liver by aromatic hydroxylation, producing numerous metabolites. Excreted in the form of metabolites in urine and feces. The half-life is 24 hours.

Calcium levomefolate has rapid absorption. It is delivered to organs and peripheral tissues in the form of L-5-methyl-THF. Folates are involved in the biosynthesis of purines, thymidine, DNA, RNA, glycine, and methionine. It is excreted mainly by the kidneys, both in its original form and in the form of metabolites, as well as through the intestines.

Yarina's analogues

Level 4 ATC code matches:
Ovidon

Rigevidon

Non-Ovlon

Mercilon

Yarina Plus

Miniziston 20 fem

Novinet

Microgynon

Janine

Lindineth

Cyclo-Proginova

Regulon

Logest

Midiana

Belara

Femoden

Jess Plus

Jess

Zoely

The most common analogues: Dailla, Regulon, Vidora, Jess, Midiana, Claira, Janine, MODELL, Dimia, Simicia .

The price of Yarina's analogues is usually less affordable than the price of the described drug.

Which is better: Midiana or Yarina?

Midiana and Yarina are complete analogues in composition and quantitative ratio of components in the preparation. Reviews indicate that there are no fundamental differences in the effect of these two products. Midiana is cheaper in cost. The choice should be made based on economic considerations and individual tolerance.

Which is better: Novinet or Yarina?

Novinet and Yarina differ somewhat in their active ingredients, but not in their mechanism of action. The cost of Novinet is almost 2 times cheaper, and in addition to the contraceptive effect, it reduces the risk of developing iron deficiency anemia . The choice is made based on the doctor’s recommendations and economic considerations.

Which is better: Yarina or Regulon?

Regulon and Yarina are analogs and only slightly differ in the structure of the active ingredients. The mechanism of action is identical. Reviews do not record differences in the incidence of side effects. The price of Regulon is approximately 2 times lower than the price of the described medicine.

Which is better: Yarina or Klaira?

Klaira, unlike Yarina, has a lower concentration of hormonal components and is recommended for use by more mature women. The prices of the drugs are comparable. The choice is based on the recommendations of the attending physician and individual indications.

Diana is 35 or Yarina – which is better?

Diana 35 and Yarina are analogues in terms of mechanism of action and effect. However, it is worth noting that the first has a lower concentration of hormonal components and a higher price. Side effects and therapeutic effect depend on individual characteristics.

Yarina and Yarina Plus

The differences between Yarina and Yarina Plus are that the latter drug additionally contains calcium levomefolate , which reduces folate in the body of the woman and fetus in the event of an unplanned pregnancy. The prices of the drugs are comparable.

Janine or Yarina - which is better?

Zhanine and Yarina are analogue drugs. According to statistics, Yarina demonstrates a greater ability to provoke side effects. The prices of the drugs are almost equal.

Indications for use

Who is Yarina suitable for, and in what cases is she prescribed?

Yarina tablets are needed for protection against pregnancy (for healthy women), as well as for the treatment of certain gynecological problems and acne.

Therapeutic effects from Yarina

Restoration of the menstrual cycle
Reducing pain and PMS symptoms
Reducing blood loss during menstruation (or getting rid of intermenstrual bleeding)
Reducing the risk of developing uterine and ovarian cancer
Preventing Endometriosis
Prevention of anemia caused by iron deficiency
Treatment of moderate forms of acne (from acne on the face)
Preventing edema (removing excess fluid from the body while preserving potassium)
Prevention and treatment of excess greasiness in hair and skin, sulfur, the appearance of unwanted body hair (hirsutism)
Prevention and treatment of dysmenorrhea

Sometimes, to facilitate pregnancy, doctors prescribe Duphaston after Yarina. This is necessary in order to restore the endometrium, which may become thinner while taking OCs. You need to drink Duphaston strictly after ovulation for 10 days (if the cycle is 28 days, then you drink it from the 16th to the 25th day of the cycle).

Pregnancy and Yarina - read.

Yarina is also often prescribed by doctors for polycystic ovarian disease (cyst). The drug has proven itself well as a therapeutic measure for polycystic ovary syndrome, as well as in cases with single large tumors.

Yarina for endometriosis

Endometriosis is a female disease of the reproductive period (develops against the background of an increase in the amount of estrogen and a decrease in the amount of progesterone). At an early stage, it can be treated with hormonal drugs. Usually either Janine or Yarina is prescribed. The second drug is preferable in some respects.

https://youtu.be/C6QN6KxIEjE

Why Yarina?

This is a newer and more active drug due to the content of a larger proportion of the main components
Yarina's absorption period is only 1.5 hours
The list of contraindications for the use of Yarina is much smaller than for other drugs (for example, Zhanine)
Even after stopping taking Yarina, a positive effect of the drug is observed (hormonal balance is restored, tissue proliferation stops, neoplasms resolve)

Yarina with adenomyosis

Yarina is prescribed as part of the complex treatment of adenomyosis (internal endometriosis).

Adenomyosis is a chronic gynecological disease. At the initial stage, the pathological process is asymptomatic; over time, complications are possible, including infertility.

Main signs of the disease:

long and heavy menstruation
pelvic pain of varying intensity and nature

Visit your gynecologist regularly to detect pathology in a timely manner.

Yarina for uterine fibroids

Uterine fibroids are a benign tumor that develops from the muscle cells of the uterus. For a long time, the tumor may not show any signs and not cause discomfort to the woman. .

When diagnosed with uterine fibroids, Yarina is prescribed to normalize the cycle, reduce the amount of menstrual blood loss (which stops the growth of fibroids), eliminate painful sensations during menstruation, to block ovulation, to prevent malignant tumors of the uterus and ovaries, as well as to prevent anemia.

Due to the monophasic nature of Yarina, containing both estrogens and progesterones, the nutrition of the fibroid first stops, after which it stops its development and freezes.

Yarina with an ovarian cyst

The cause of cysts is hormonal imbalance. A cyst is a sac filled with fluid. As it grows, it can cause the development of polycystic ovary syndrome, and then infertility. When walking, exercising, or during sexual intercourse, cysts provoke pain in the lower abdomen.

https://youtu.be/XkNm8thZYvU

How does Yarina work? At the level of the hypothalamic-pituitary system, the production of follicle-stimulating hormone is blocked (lack of ovulation). The permeability of cervical secretions for sperm decreases, and egg implantation also does not occur. As a result, during the period of taking OK, the female reproductive system has the opportunity to completely rest and recover.

Yarina for mastopathy

The mammary gland is very sensitive to sex hormones. Violation of their balance leads to the development of mastopathy and its unpleasant manifestations.

Oral contraceptives when taken regularly:

reduce proliferative processes in the breast (uncontrolled cell growth with the formation of cysts, fibroadenomas, etc. does not occur) This is achieved primarily through the establishment of menstrual function and the regulation of connections in the hypothalamus - pituitary gland - ovaries - mammary glands.
help reduce the level of estrogen in the blood (protect the breasts from their excessive influence).
have a therapeutic effect on the organs of the woman’s reproductive system.
reduce the risk of breast cancer by 2 times. The effect of taking it lasts for 10 years, so it is preferable to use hormonal contraceptives after 30–35 years of age.
reduce the rate of progression of mastopathy.

Yarina for endometrial hyperplasia

Hyperplasia must be treated comprehensively. Therapy should consist of several successive stages. Yarina is used at the first stage of treatment (reception can last up to six months).

The first stage of treatment is to stop the bleeding. If the drug does not work, then curettage of the uterine cavity is performed and a number of hemostatic drugs are administered to stop the bleeding.

If necessary, blood substitutes and drugs that normalize the water-salt balance in the body are also administered. In some cases, intravenous injections of vitamins B, C, rutin and folic acid are given.

During pregnancy and lactation

The medicine is not prescribed for detected pregnancy and lactation.

If pregnancy is detected while using Yarina, the medicine must be discontinued immediately. Studies have not found an increased risk of developmental defects in newborns whose mothers took sex hormones before or during early pregnancy. At the same time, the use of combined contraceptives can reduce the volume of breast milk and change its composition, so the use of such drugs is not recommended until breastfeeding is completed.

Reviews about Yarina

Reviews from doctors about Yarin are quite restrained in characterizing the drug, which has its own advantages and disadvantages.

The online forum reports that a fairly large number of women who took Yarina hormonal pills developed a variety of side effects: from acne and other skin changes to severe vascular disorders. Other reviews reported that birth control pills, on the contrary, have a beneficial effect on the condition of the skin and are recommended for polycystic ovary syndrome .

Reviews from doctors about tablets for endometriosis indicate positive treatment results with continuous dosing. This regimen of use contributes to the suppression of menstrual function, inhibits retrograde blood flow to the pelvic organs and stimulates regression in endometrioid heterotopias . The duration of treatment for endometriosis is at least six months.

Reviews of Yarin after discontinuation are usually satisfactory, but sometimes changes may appear in the form of weight gain or the appearance of acne . There are a number of reports that there are no periods after withdrawal. The situation is considered normal if there are no periods within 4-5 days after stopping taking birth control pills. But if they do not appear within a week, you should consult a gynecologist for advice.

Yarina and pregnancy after her

The forum and numerous reviews indicate that pregnancy after discontinuation of the drug is not accompanied by deviations in its course or pathological changes in the development of the fetus.

Yarina price, where to buy cheap

The price of birth control pills Yarina (No. 21) in Ukraine does not fluctuate depending on the region - both in Odessa and in the city of Kharkov it is 240-290 hryvnia.

How much does it cost in Russian pharmacies?

The price of Yarina tablets (No. 21) in Russia is 810-890 rubles. The cost of a package of 63 tablets can reach 2,300 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Yarina tablets p.p.o.
3mg+0.03mg 21 pcs. Bayer Weimar GmbH and Co. KG/Bayer AG RUB 1,136 order
Yarina tablets p.p.o. 3mg+0.03mg 63 pcs. Bayer Weimar/Bayer Pharma
RUR 3,040 order
Yarina Plus tablets p.p.o. 3mg+0.03mg+0.451mg 84 pcs. Bayer Weimar/Bayer Pharma
RUB 3,192 order

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Yarina plus (table p/o No. 28x3) Bayer
RUB 3,193 order
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RUB 1,097 order
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Yarina plus N28 tablets - 3 packs Promotion of Bayer Pharma AG, Nimecchina/Bayer Weimar GmbH i Co.
KG, Nimechchyna 631 UAH.order
Yarina No. 21 tablets Bayer Pharma AG, Nimechchina/Bayer Weimar GmbH i Co. KG, Nimechchyna
271 UAH order
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261 UAH. order

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Yarina tablets Yarina tablets. p/o No. 21 Germany, Bayer Pharma
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Yarina plus tablets Yarina Plus tablets No. 28 (21+7) Set 2+1 Germany, Bayer Pharma
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Yarina plus tablets Yarina plus tablets No. 28 Germany, Bayer Pharma
271 UAH order

Release form and composition

The dosage form of the drug Yarina Plus is film-coated tablets: round, biconvex; active tablets are orange and Y+ embossed in a regular hexagon, auxiliary vitamin tablets are light orange and M+ embossed in a regular hexagon (21 active and 7 auxiliary vitamin tablets in a blister, in a cardboard box 1 or 3 blisters and a block of stickers for registration of the reception calendar).

Composition of 1 active tablet:

active ingredients: drospirenone – 3 mg, ethinyl estradiol betadex clathrate in terms of ethinyl estradiol – 0.03 mg, calcium levomefolate – 0.451 mg;
auxiliary components: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hyprolose (5 cP), magnesium stearate;
film shell: orange varnish; or hypromellose (5 cP), macrogol-6000, talc, titanium dioxide, yellow iron oxide dye, red iron oxide dye.

Composition of 1 supplementary vitamin tablet:

active substance: micronized calcium levomefolate – 0.451 mg;
additional components: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hyprolose (5 cP), magnesium stearate;
film shell: light orange varnish; or hypromellose (5 cP), macrogol-6000, talc, titanium dioxide, yellow iron oxide dye, red iron oxide dye.