Instructions for use of Indomethacin suppositories and customer reviews

If you need to purchase a strong anti-inflammatory drug from the non-steroidal group, first of all you should pay attention to Indomethacin.

In the pharmacy you can find tablets, ointments, solutions and drops, but the most well-known way to release the drug Indomethacin is suppositories.

The instructions for use state that this product helps to quickly solve diseases associated with inflammatory processes, while at the same time providing an antipyretic and analgesic effect.

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How to use Indomethacin ointment

Even if only external agents are used, an excess of their main active ingredient may accumulate in the body.
Indomethacin ointment should be used strictly according to the instructions and in accordance with the recommendations of the attending physician. Self-medication is unacceptable, since the drug is based on a potent ingredient. The dosage, duration and frequency of use are selected individually, in accordance with the patient’s age and the size of the affected area. The manufacturer does not recommend using more than 15 cm of ointment squeezed out of the tube per day for adults, and no more than 7.5 cm for children over 6 years old. The diameter of the outlet of the tube from different manufacturers is usually the same, and an overdose of the drug is unlikely. The following symptoms indicate an overdose of Indomethacin ointment:

• unusual taste in the mouth,
• feeling of nausea or vomiting during treatment,
• impaired coordination and memory,
• cramps or numbness of the limbs,
• parasthesia - tingling, goose bumps,
• headache, dizziness, fainting.

If, after applying the ointment, at least one of the signs of an overdose is observed, but the dose recommended by the doctor has not been exceeded, you must stop using the drug and consult a medical specialist. Usually, after stopping treatment or reducing a single dose, symptoms disappear, but sometimes symptomatic therapy is necessary.

You cannot continue to use Indomethacin ointment if there are side effects and signs of overdose, as more serious problems may appear - pulmonary edema, ulcerative lesions of the gastrointestinal tract, surges in blood pressure, destruction of the skin in the area of ​​application.

Analogs

Analogues of the drug are products with the same active substance.

1. Indomethacin Sopharma suppositories. In addition to the main active ingredient, such a drug also contains solid fats. The product has an extended list of contraindications. Use only as prescribed by a doctor and under his constant supervision.
2. Indomethacin Altfarm suppositories. This drug has the same contraindications for use that are typical for suppositories with indomethacin, but an expanded list of side effects. The drug can adversely affect the activity of almost all human organs and systems.
3. Indomethacin Berlin-chemi suppositories. In addition to indomethacin, the product contains solid fats and corn starch. It is this composition that determines the beneficial properties of the product. The drug has an extended list of both side effects and contraindications. In particular, indomethacin Berlin-chemi suppositories cannot be used by minor children until they reach the age of eighteen.

Any of these products should only be used as directed by a physician.

Instructions for use

Indomethacin ointment is considered an antirheumatic and anti-inflammatory agent.
It can reduce swelling of the affected area of ​​the body, remove stiffness of movement, relieve pain, and easily relieve inflammation and fever. The product allows you to eliminate pain after injuries and operations, and even those that appear periodically and suddenly, reduces swelling and inflammation near open wounds.

Indomethacin in the form of an ointment is an active external anti-inflammatory agent related to non-steroidal anti-inflammatory drugs. Its action is due to the inhibition of cyclogenase, which inhibits the synthesis of prostaglandins, suppresses the inflammatory phases, and inhibits platelet aggregation.

Indications

Indomethacin ointment is used in the following cases:

1. For degenerative and inflammatory diseases of the musculoskeletal system and inflammation of soft tissues (psoriatic, gouty and rheumatoid arthritis, rheumatism, ankylosing spondylitis, bursitis, osterarthrosis, tendinitis, etc.).
2. Neuralgia, myalgia, pain in the spine, radiculitis, plexitis, neuritis, sciatica, lumbago, etc.).
3. Traumatic inflammation in the abdominal cavity and soft tissues (with dislocations, sprains, after bruises or stress).
4. For postoperative swelling with no violations of skin integrity.
5. With superficial thrombophlebitis.

Directions for use and doses

The ointment is applied to the affected area in a thin layer with light movements 3 times a day (2 times for children).

The maximum dose for adults is no more than 15 cm of the product squeezed out of the tube, for children – 7 cm. The use of occlusive dressings with ointment is not recommended.

The product should not be applied to damaged areas of the skin, and should also be protected from contact with open wounds and mucous membranes.

Every 10 days during treatment with ointment, the general condition of the blood is checked.

Contraindications

Indomethacin ointment is contraindicated for use in the following cases:

1. If the patient's body is hypersensitive to the components of the drug.
2. In the acute phase of peptic ulcers in the gastrointestinal tract.
3. With severe renal and liver failure.
4. In places where the integrity of the skin is damaged.
5. For disorders in the hematopoietic system.
6. In cases of blood clotting disorders of unknown etiology.
7. Children under 6 years old and the elderly.

Overdose

The low systemic absorption of Indomethacin ointment when applied externally makes it almost impossible to overdose the drug.
But when using the product in an amount exceeding that recommended in the instructions, migraines, nausea, vomiting, and dizziness may occur. Cramps and numbness of the extremities also sometimes occur.

If the ointment is accidentally ingested, several side effects may develop simultaneously.

Side effects

Using Indomethacin ointment sometimes causes the following side effects:

1. The appearance of various rashes.
2. Allergic reaction.
3. Dryness, itching and hyperemia of the skin.
4. The appearance of a burning sensation at the application sites.

Very rarely, side effects can progress to attacks of suffocation and angioedema. Psoriasis may also develop on the skin at the application sites. If such phenomena occur, stop using the drug immediately and consult a doctor for further instructions.

Composition and pharmacokinetics

The drug in the form of an ointment in 1 g contains indomethacin 100 mg, which is the active ingredient.
The following auxiliary components are used: urea, transcutol R, PEG 400 and 1500, nipagin, propylene glycol, levomenthol, nipazole and distilled water. When applied externally, the active substance is immediately absorbed, ending up in the subcutaneous tissues within 5 minutes. The components of the ointment enter the synovial membrane and joint fluid, remaining active there for 5-7 days.

In the blood, the active substance binds to plasma proteins. Its metabolism occurs in the liver with the formation of negative products that are excreted through the intestines and kidneys.

Other

The ointment is available in pharmacy chains for free sale, but without a doctor’s prescription, the duration of its use cannot exceed 2 weeks, since self-medication with the use of this drug often leads to negative consequences.

Indications

It is already known how Indomethacin suppositories work in gynecology, for which suppositories are prescribed also needs to be considered in more detail. Specialists in this field of medicine practice introducing medication into a therapeutic complex in the presence of the following pathologies:

1. Menstrual bleeding accompanied by severe pain;
2. Damage to the uterine mucosa (endometriosis);
3. Inflammation of the bladder (cystitis);
4. Cyst on the ovary;
5. Inflammation of the appendages;
6. Inflammation of the fallopian tubes and ovaries;
7. Oophoritis;
8. Endometritis;
9. Myometritis;
10. Uterine fibroid;
11. Relief of pain after surgical interventions on the genital organs.

It is worth noting once again that suppositories are almost always used vaginally; in rare cases, specialists prescribe suppositories with Indomethacin to patients in gynecology rectally. Since the medicine is aimed at stopping the inflammatory process and reducing pain, it is not used in diagnosing pathologies of an infectious nature.

Indomethacin suppositories have quite broad indications for use in gynecology, for example, some obstetricians prescribe them to women not only to maintain pregnancy (only in the first or second trimester), but also, if necessary, to relieve pain in the prenatal period.

For cystitis

Considering Indomethacin suppositories in gynecology, for which this medicine helps, it must be said that it is often prescribed for an inflammatory process affecting the genitourinary organs. Cystitis often develops in women due to hypothermia. The main symptoms are frequent urination and pain during this process.

Initially, it is necessary to get rid of the acute period, and then carry out therapy that will not allow the pathology to become chronic. Therefore, doctors prescribe suppositories with this active ingredient, but it is important to know that the treatment must be comprehensive. Indomethacin suppositories are used in gynecology; they are used for this disease both rectally and vaginally.

With a cyst

The pathology is characterized by the formation of a neoplasm on the surface of the ovary in the form of a capsule, filled with liquid inside. The diagnosis is made after a thorough examination of the patient, and, in most cases, thanks to an ultrasound scan.

Suppositories are prescribed for ovarian cysts

Among the signs of the disease, a woman may notice minor pain in the lower abdomen (if a follicular cyst develops), and the menstrual cycle also changes (bleeding lengthens).

With a cyst with torsion, the pain syndrome is pronounced. Those who have used Indomethacin suppositories for this pathology leave different reviews of their effectiveness, but many women claim that they helped get rid of uncomfortable symptoms and speed up the recovery process.

During pregnancy

Indomethacin suppositories in gynecology are prescribed to women during pregnancy if they have been diagnosed with a condition such as increased uterine tone. The active ingredient in suppositories helps normalize it. If the contractility of the reproductive organ is not controlled, it can provoke hypoxia in the fetus (lack of oxygen), and placental abruption and spontaneous termination of pregnancy cannot be ruled out.

Doctors also leave reviews about suppositories with Indomethacin in gynecology on thematic resources. Most of them contain information that the action of the active component helps to stop the production of specific substances in the body that can enhance uterine tone.

However, using it without a medical prescription, that is, on your own, is strictly prohibited, since suppositories are not as safe as they might seem at first glance. Uncontrolled treatment can lead to the development of various pathologies in the fetus, and an overdose threatens fetal death.

Given this fact, the medicine is contraindicated for use in the last trimester of pregnancy. As for the lactation period, it is necessary to note the ability of the substance to penetrate into breast milk and affect the baby.

With algodismenorrhea

Experts prescribe vaginal suppositories with Indomethacin to women suffering from severe pain during menstrual bleeding. This condition develops due to the production of a large number of prostaglandins in the body.

To eliminate discomfort and easily tolerate algodismenorrhea, doctors advise girls to use Indomethacin suppositories in gynecology rectally. What else this drug is indicated for should be checked with doctors.

Indications for use of Indomethacin ointment

This ointment is prescribed by medical specialists to solve problems with muscle and joint structures. The product is widely used in traumatology and orthopedics, neurology and vertebrology - a scientific and experimental branch of medicine specializing in the development of innovative methods for treating the spine.

Due to the fact that the spectrum of action of Indomethacin ointment is quite wide, it is effective in the treatment of more than 25 diseases of the musculoskeletal system:

• arthritis and osteoarthritis,
• exacerbation of gout and lumbago,
• bursitis, scoliosis, sciatica,
• damage to tendons and ligaments, including as a result of injuries,
• deforming osteoarthritis,
• tendinitis and periarthritis.

Indomethacin-based ointment is effective for osteochondrosis, lumbar and thoracic lumbago, neuralgia and myalgia, radiculitis, dislocations accompanied by inflammation and swelling. The drug is often recommended for relieving pain from fractures during the rehabilitation period. In surgery, the ointment is used as a decongestant and analgesic after operations with minimal damage to the skin or after their complete healing. Edema often serves as a provocateur of pain, that is, by reducing it, it is possible to reduce the pain syndrome, which significantly reduces the quality of life.

The drug is also effective in the treatment of superficial thrombophlebitis of the lower extremities. The disease is accompanied by swelling and a feeling of heaviness in the legs, discomfort and pain in the calves, and redness of the skin in the affected area. Indomethacin ointment can relieve unpleasant symptoms after just a few applications and maintain the resulting effect for a long time. Application is possible for both acute and chronic thrombophlebitis.

Description of rectal suppositories Indomethacin

Indomethacin suppositories have analgesic, anti-inflammatory and analgesic effects. Their action is based on stopping the formation of substances that excite nerve endings, which dulls pain and stops the inflammatory process. Pain relief occurs as quickly as possible - within 10–15 minutes. These suppositories are considered one of the most effective local non-steroidal agents.

The composition of the medicinal product includes:

• indomethacin is the active ingredient, one suppository contains 50 or 100 mg;
• corn starch and solid fat are auxiliary components.

Indomethacin-based drugs are available in various forms, but in gynecology it is recommended to use suppositories. The fact is that the substances that make up the suppositories are quickly absorbed and have an effect directly on the source of inflammation.

Indomethacin is a non-steroidal drug with analgesic, anti-inflammatory, analgesic effects

Special instructions for the use of indomethacin ointment

This local drug is used with caution for the treatment of pathologies in elderly patients, in case of a history of diseases of the gastrointestinal tract, or symptoms of dyspepsia during therapy. The use of the drug is limited immediately after surgery, for epilepsy and parkinsonism

If the patient has a history of hypersensitivity to medications from the group of non-steroidal anti-inflammatory drugs, then indomethacin ointment is used in case of emergency.

You need to be aware: during the period of using indomethacin ointment, you must refrain from forms of activity that are associated with the need for a high speed of psychomotor reactions. The drug may reduce concentration.

Before using an external agent, you should carefully read the contraindications and special instructions to minimize the occurrence of negative reactions.

Composition, release form and type of packaging

Indomethacin suppositories are very popular in many areas of medicine.
Despite the various forms of release, suppositories have the most powerful effect in an attempt to avoid high temperatures, relieve swelling or remove inflammation.

Suppositories are used for rectal administration, most often they are inserted into the rectum, but in some cases, gynecologists often insert it into the vagina for women.

Each cardboard box of Indomethacin suppositories contains 5 or 10 pieces.

They are standard white or slightly yellowish in color. The active substance of this drug is indomethacin.

Thanks to its action, it reduces emerging inflammation and helps relieve swelling. Additionally, fat and paraffin paraffin, corn starch are added to this. Witepsol N15 is added from time to time.

Candles are produced in several countries at once:

• to Germany;
• in Bulgaria - Sopharma;
• In Russia, the drug is produced by 2 companies at once - Altfarm and BioSintez.

Pharmacology and pharmacokinetics

After introducing Indomethacin suppositories into the rectum, they begin to melt under the influence of the heat of the human body. As it melts, the active substance begins to penetrate the walls, producing an effect.

The product has several types of effects simultaneously:

• antipyretic;
• anti-inflammatory;
• pain reliever;
• decongestant.

Getting directly into the blood, completely ignoring the intestines and stomach, it is absorbed by the body and inhibits the release of the hormone prostaglandin. It is this hormone in the body that is responsible for the rapid development of inflammation and pain.

With regular use, Indomethacin suppositories help suppress all chronic inflammation, while relieving all pain and stiffness. Within a week from the start of use, you can feel significant improvements.

The main active ingredient of the suppositories is indomethacin, after entering the blood it reaches its maximum effect only after 1-2 hours, and it is best not to eat any food during this time, since the effect of the medicine will be much less regardless of the amount consumed.

Indomethacin has a very high absorption rate. After the end of action, it is excreted through the kidneys or gastrointestinal tract, however, due to its rapid action, it can often pass into breast milk and the placenta.

Side effects and contraindications for use

In addition to its positive properties, like any drug, Indomethacin has negative side effects. In first place are allergic reactions, which manifest themselves in the form of skin itching, hives, redness, rashes on the skin and mucous membranes. Also, side effects such as headache, dizziness, nausea, vomiting, and drowsiness cannot be ruled out.

Even when used externally, the drug can negatively affect the course of gastrointestinal diseases - gastric and duodenal ulcers, gastritis and esophagitis. The drugs provoke bleeding and menstrual irregularities.

Indomethacin is not used during pregnancy and lactation. Contraindications include:

• Hypersensitivity to drug components.
• Bleeding of various origins.
• Congenital heart defects.
• Cirrhosis of the liver.
• Bronchial asthma.
• Diseases of the optic nerve.
• Edema of various origins.
• Heart failure.
• Hypertonic disease.
• Chronic hepatic-renal failure.
• Disorders of the blood coagulation system.
• Children's age up to 14 years.

Today, indomethacin ointment and gel are the cheapest and most accessible, but not inferior in effectiveness to expensive modern drugs.

Use during pregnancy and breastfeeding

During pregnancy and lactation, suppositories with indomethacin are prohibited for the treatment of any pathologies. The drug negatively affects the development of the child, slowing down growth and mental development, and also negatively affects the formation of certain organs and systems.

Suppositories can be prescribed by a doctor in the second trimester, but only as a last resort if the health of the expectant mother is in danger and other methods of therapy have proven ineffective.

In the first and third trimester, the product is prohibited for use. Suppositories also cannot be used during lactation, since the drug passes into the mother's milk, which can harm the baby.

What are the prohibitions on medicine?

Indomethacin ointment should not be applied in the following situations:

1. Intolerance to drug substances.
2. Kidney diseases.
3. Bronchial asthma (chronic inflammatory damage to the respiratory system with the participation of various cellular elements).
4. Treatment of intervertebral and hip joints.
5. Liver lesions.
6. Diseases of the heart and blood vessels.
7. Age up to one year.

According to the instructions, the drug "Indomethacin" should be used with extreme caution when:

1. Hemorrhoids (inflammation that is associated with thrombosis, as well as pathological expansion and tortuosity of hemorrhoidal veins that form nodes around the rectum).
2. Hypertension (a serious chronic disease characterized by a persistent increase in blood pressure).
3. Pancreatitis (a disease characterized by acute or chronic inflammation of the pancreas).
4. Up to six years of age.
5. Breastfeeding.
6. Stomach or duodenal ulcer.
7. Problems with blood clotting.

special instructions

Additional recommendations and precautions:

1. Indomethacin suppositories should be used with extreme caution , since the active substances can react strongly and cause side effects;
2. After the introduction of suppositories, foreign sensations may appear in the rectum. These symptoms are not problematic and do not require discontinuation of treatment;
3. One of the side effects of the medicine is dizziness , so it is not recommended to drive a car or perform work that requires an increased level of concentration.

Recommendations for choosing ointment for joints

Any painful sensations in the muscles, joints, and spine make you think about the need to choose external medications to relieve discomfort. Only a doctor prescribes a course of therapeutic correction after carrying out all the necessary diagnostic measures. But you should still be aware of what local drugs are and why they are prescribed for diseases of the musculoskeletal system.

Groups of external products

Main groups of drugs for topical use:

• nonsteroidal anti-inflammatory drugs, which include indomethacin ointment;
• chondroprotectors;
• ointments with a warming and irritating effect;
• ointments based on steroidal anti-inflammatory drugs.

Medicines from the first group - non-steroidal anti-inflammatory external drugs - are effective and fast-acting. They are over-the-counter products: they can be purchased at any pharmacy after receiving doctor's recommendations. The drugs in this group include, in addition to indomethacin, such popular drugs as Diclofenac, Ketonal, Nise-gel, Ortofen and others.

Chondroprotectors (and others) for external use include glucosamine and chondroitin, which are necessary for regenerative processes in joint structures.

Warming, irritating external products are made on the basis of plant extracts (capsaicin), essential oils, snake and bee venoms

May provoke allergic reactions, so should be used with caution. Do not apply to damaged, irritated skin

Such drugs include Capsicam, Apizartron and others.

Sometimes the doctor may prescribe local remedies with active components of the steroid structure. These medications have a pronounced anti-inflammatory effect.

Why the choice of external products should be entrusted to a specialist

In case of sudden attacks of pain, patients neglect the need to visit a doctor, and immediately independently select an external medicine or some folk method of getting rid of unpleasant sensations. This is not recommended - attempts to self-correct the pathology can aggravate its course.

Medical consultation is necessary because only a doctor can carry out the necessary diagnostic procedures and determine the cause of the symptoms that bother the patient. After this, the doctor will prescribe a comprehensive treatment, including not only external medications, but also internal medications, physiotherapy, massage and physical therapy exercises.

Directions for use and doses

The instructions for use recommend placing the candles into the anus with the pointed end. You should first perform perineal hygiene and take a comfortable position: lying on your back or on your side. After the suppository is inserted (no deeper than 2-3 cm), you should lie down for about 30-40 minutes.

The instructions for use explain how to take indomethacin suppositories, but only the doctor can indicate how much. A specialist who has previously made a diagnosis has the right to prescribe the dosage and duration of therapy. Based on the clinical picture of the disease, the type of infection, and the severity of organ damage, conclusions are drawn - it is strictly forbidden to violate the course regimen.

Advice! If the doctor has prescribed to take half a suppository 4 times a day, then the suppository is slightly heated at room temperature and cut in half lengthwise with a sharp knife. There is no need to cut across, you cannot insert the candle with a blunt end - this will lead to the appearance of cracks in the anal area.

There are a huge number of indications for taking the drug. Indomethacin is an excellent suppository for sexually transmitted infections, for the prevention of diseases and infections of the genitourinary system. Suppositories are often used in gynecology and problems with the musculoskeletal system - the anti-inflammatory and antibacterial effect allows you to quickly achieve symptom relief and get rid of exhausting pain. But to cure chronic or aggravated prostatitis, suppositories alone are not enough; complex therapy with broad-spectrum antibiotics will be required.

Instructions for use

Apply the product in a medium layer and rub in a little. Too little amount of product will not produce results. There is no need to press hard on the skin and joints. For 20 minutes, the area with the applied medicine is left to soak, avoiding contact with clothing and other tissues. When the allotted time is up, remove the remaining medication with a cotton swab or a clean napkin.

You can measure the permissible norm in centimeters. For adults, up to 15 cm of ointment can be used per day. For children over 14 years old, up to 7.5 cm is recommended.

The medicine can only be used on areas of damaged ligaments, cartilage and tendons. Do not allow the drug to come into contact with mucous membranes.

The course of treatment with the drug lasts up to 8 days. Sometimes the drug is used longer - in parallel it is necessary to monitor the number of platelets in the blood.

Properties

Suppositories can be used both rectally and vaginally (in women). This drug, penetrating into the bloodstream, inhibits the production of prostaglandin hormones.

Their production contributes to the development of inflammation and pain. Due to the good absorption of this drug, the therapeutic effect occurs quite quickly, within the first week from the start of use.

Unlike tablets, suppositories have a great advantage when using them. They are not exposed to acids and enzymes in the gastrointestinal tract, but enter directly into the bloodstream.

Instructions for use

Indomethacin has a number of special parameters that require impeccable execution. These characteristics include:

The ointment should not be used for children under 14 years of age! The child’s body is still weak and not yet strong, which makes it difficult to completely remove the drug. Accumulating in the body, Indomethacin can lead to intoxication. For the same reason, this medicine is not prescribed to pregnant women. During lactation, Indomethacin is also contraindicated.

For an adult, the ointment has a beneficial effect, but for a baby it can be detrimental. Increased attention should be paid when driving vehicles and working with dangerous mechanisms. The ointment can cause symptoms that distract from important processes that require concentration. You should be careful when using Indomethacin as an ointment for hemorrhoids

It is necessary to provide only a local effect in an amount strictly specified by a specialist.

In any case, if suspicious symptoms occur after using this medicinal substance, precautions must be taken

Drug interactions

The drug should not be used with aspirin or other similar medications. Taking the products together leads to an increase in the toxicity of cyclosporine, which can cause poisoning of the body.

It is not recommended to take indomethacin suppositories together with diflunisal. This combination can lead to hemorrhage in the gastrointestinal tract.

If the drug is used together with probenecid, this will lead to an increase in the concentration of indomethacin in the blood. An increased content of the substance will not have a positive effect on the treatment of the pathology, but will lead to undesirable consequences due to an overdose of the drug.

With the simultaneous use of suppositories and beta-blockers and saluretics, suppositories reduce the effectiveness of these medications. Combining the use of indomethacin with indirect anticoagulants increases the effect of the latter drugs.

The dosage of indomethacin suppositories 50 mg three times a day leads to an increase in the concentration of lithium in the blood and reduces the rate of elimination of lithium from the body in people suffering from mental disorders.

Doctors do not advise combining the drug with digoxin, since the concentration of digoxin in the blood increases.

The use of indomethacin suppositories in combination with other drugs may change the chemical composition of some components in both drugs.

Such a change can cause significant harm to the body. Before starting to use suppositories as prescribed by a doctor, it is necessary to study the interaction of indomethacin with other drugs.

The use of indomethacin suppositories with other drugs
Acetylsalicylic acid	There are contraindications due to the likelihood of internal bleeding
Non-steroidal drugs
Cefoperazone	Blood clots may appear
Parayetamol, cyclosporine, gold preparations	Possibility of nephrotoxic effect
Diuretics	Reduces efficiency
Probenecid	Overdose of indomethacin in the blood
Drugs containing: diflunisal, colchicine	Internal bleeding and housing and communal services complications may occur
Digoxin, lithium salts, immunosuppressants	Increases drug toxicity
Probenecid	Increases the toxic effect of indomethacin
Antiplatelet and anticoagulant drugs	Increased risk of ulcers and bleeding
Pentoxofylline
Zidovudine	Increases the myelotoxicity of indomethacin
Tacrolimus
Bisphosphonate	Increases the bioavailability of indomethacin

Combination with other medications

The drug interacts with some medications, which should be taken into account when using it. When used simultaneously with antihypertensive drugs, as well as with diuretics and uricosuric drugs, the effectiveness of the latter decreases.

Indomethacin ointment can increase the effect of anticoagulant drugs, fibrinolytics, as well as drugs that have an inhibitory effect on platelet production. In addition, when taking mineralocorticoids and NSAIDs simultaneously, the risk of adverse reactions increases. In combination with sulfonylurea, the hypoglycemic effect increases.

In combination with indomethacin ointment, Paracetamol increases the likelihood of developing nephrotoxic syndrome.

The risk of gastrointestinal syndrome increases when combined with colchicine, ethyl alcohol and glucocorticoids.

The toxic effect on the kidneys increases when the ointment is combined with medications containing gold and cyclosporine. In addition, indomethacin increases the plasma concentrations of digoxin, lithium and methotrexate.

The likelihood of developing a lack of prothrombin in the blood and bleeding increases with the simultaneous use of ointment with cefamandole, valproic acid and cefoperazone. The intensity of elimination of antibacterial drugs from the penicillin group is reduced when using indomethacin. The toxic properties of zidovudine also increase.

Adverse reactions

The use of suppositories with indomethacin may cause the following adverse reactions:

• in the central nervous system - depressed state, dizziness and fainting, lethargy and drowsiness even after a long rest, problems with going to bed at night, as well as the quality and duration of sleep, loss of sensitivity in the fingers of the upper extremities, involuntary contraction of the arm muscles;
• in the area of ​​the cardiovascular system - pressure changes, swelling of soft tissues, tachycardia, heart failure, pain in the heart area;
• in the gastrointestinal tract - pain in the abdomen, stool disturbances, lack of appetite, dry mouth, nausea, exacerbation of chronic gastrointestinal pathologies, cramps, bloating, enlarged liver;
• in the area of ​​the circulatory system – a decrease in the number of leukocytes, but extremely rarely;
• manifestations of allergies - discomfort in the anal area, rash on the epidermis, rarely - Quincke's edema.

Cases of bleeding from the vagina and nose, pain and increased sensitivity of the breast were also recorded.

Composition and pharmacological action

The main active substance of the external agent Indomethacin ointment is represented by indomethacin.
The composition of the external product is supplemented with auxiliary components in the form of petroleum jelly, anhydrous lanolin, silicon dioxide, lavender oil, stearyl alcohol and beeswax.

Local application of Indomethacin ointment prevents the active components from being absorbed into the systemic bloodstream, and due to this it can be used for a long period without side effects on the body

Spectrum of action of external agents with indomethacin:

1. reduces pain with inflammation in muscle and joint tissues caused by rheumatic and non-rheumatic causes;
2. eliminates joint pain at rest and pain of movement;
3. relieves morning stiffness in joints;
4. increases the range of motion along all axes of the joint;
5. relieves spontaneous pain, pain when moving;
6. eliminates tissue swelling caused by inflammation;
7. reduces the permeability of the walls of capillary and small vessels.

How to use indomethacin suppositories rectal and vaginal

In indomethacin suppositories from various manufacturers, the main active ingredient is indomethacin.

It helps relieve symptoms of various diseases, but does not change the progressive course of the disease.

The popular indomethacin suppositories produced by Biosintez include:

• Active ingredient: indomethacin - 50 mg or 100 mg.
• Auxiliary ingredients: solid fat, urea, colloidal silicon dioxide, castor oil, nipazole and polysorbate 80.

The composition of indomethacin suppositories produced by Berlin-Chemie also includes indomethacin, but the auxiliary components are only solid fat and corn starch.

The composition of indomethacin suppositories produced by Sopharma includes:

• Active ingredient: indomethacin - 50 mg or 100 mg.
• Auxiliary ingredients: petroleum jelly, lavender oil, colloidal silicon dioxide, lanolin, beeswax and dimethyl sulfoxide.

The method of administration is rectal or vaginal, depending on the disease. For example, for hemorrhoids, lower back pain or prostatitis, suppositories are inserted only into the rectum (rectally), and for female gynecological diseases (for example, cystitis) - either vaginally or rectally. The gynecologist will tell you exactly how.

How to use indomethacin suppositories rectally:

1. If the suppository is too soft to insert, place it in cold water or refrigerate for 30 minutes before removing the foil wrapper.
2. Remove the foil and moisten the suppository with a little water.
3. Lie on your left side, slightly lift your right knee. Left-handed people should lie on their right side and raise their left knee.
4. Insert about 2.5 cm of the suppository into the rectum using your finger.
5. Remain lying down for several minutes and avoid bowel movements for at least one hour to allow the medicine to be completely absorbed into the rectal wall.

Dosage depends on your medical condition and response to treatment. Adults should not use more than 200 milligrams per day. For children, the dosage is calculated depending on weight. The maximum dose for children is 4 mg per kilogram per day, or 150 to 200 milligrams per day.

Important

To reduce the risk of side effects (such as stomach bleeding), use this drug at the lowest effective dose for the shortest possible time.

There is no need to increase the dose or use it more often than prescribed. Under certain conditions (eg arthritis), treatment may take up to 4 weeks before the suppositories are fully effective.

How to use indomethacin suppositories vaginally:

1. It is advisable to insert suppositories before bed, after placing a piece of cloth under the pelvic area (in case the contents of the suppository leak out of the vagina).
2. Remove the packaging from the suppository.
3. Lie on your back and bring your knees to your chest.
4. Carefully insert the suppository as far into the vagina as possible. You shouldn’t try to push it as deep as possible, but it shouldn’t be close to the “entrance”, otherwise it will leak out.
5. Lie down without moving for 15 minutes.

Side effects

According to the instructions for use and reviews of Indomethacin, the digestive system may react to taking the drug with flatulence, nausea and vomiting, gastrointestinal bleeding, anorexia, jaundice, unpleasant or painful sensations in the abdomen, gastritis, constipation, diarrhea, gastrointestinal perforation, erosive gastrointestinal lesions, stomatitis, intestinal stricture, bleeding from the sigmoid colon or diverticulum, hepatitis.

On the part of the nervous system, during the use of Indomethacin, undesirable effects of the active component may appear, such as: involuntary muscle contractions, convulsions, peripheral neuropathy, depersonalization, psychotic episodes, other mental disorders, anxiety, sleep disturbance, fatigue, paresthesia, depression, parkinsonism, headaches, dysarthria, dizziness, fainting, muscle weakness.

From the CV side, undesirable effects may develop such as arrhythmia, chest pain, arterial hypotension, tachycardia, palpitation, increased blood pressure, congestive heart failure, swelling, hematuria. What else does the instructions for Indomethacin tell us?

From the hematopoietic system - hemolytic anemia, purpura, aplastic anemia, DIC syndrome, thrombocytopenia, ecchymosis, leukopenia, petechiae.

Urinary system: interstitial nephritis, proteinuria, nephrotic syndrome, renal failure, impaired renal function.

Also, from the senses, undesirable reactions such as periorbital pain, tinnitus, diplopia, hearing impairment, visual perception disorders, and deafness may occur.

On the metabolic side, the development of hyperglycemia, glucosuria, and hyperkalemia cannot be ruled out.

Among other things, while taking it, various undesirable allergic reactions may occur, such as: angioedema, Lyell's syndrome, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, erythema nodosum, urticaria, angiitis, hair loss, bronchial asthma, respiratory distress, dyspnea, anaphylactic phenomena, pulmonary edema, a sharp drop in blood pressure, rash and itching.

The instructions for Indomethacin contain this entire list of adverse reactions.

Other undesirable effects include breast tenderness (enlargement), nosebleeds, hot flashes, hyperhidrosis, vaginal bleeding, and gynecomastia.

Additionally, when using rectal suppositories, the following may develop: exacerbation of hemorrhoids, tenesmus, irritation of the mucous membranes in the rectum, exacerbation of colitis.

When using Indomethacin in the form of external ointments, undesirable effects may occur, such as exacerbation of psoriasis, burning at the site of application, hyperemia, as well as dry skin, rash and itching at the site of application, allergic manifestations, systemic manifestations (if the drug used for a long time). The instructions and reviews for Indomethacin confirm this.

Side effects

Suppositories containing Indomethacin should be used with extreme caution. Violation of the dosage, as well as non-compliance with medical recommendations, often leads to the development of negative reactions in the body.

In particular, doctors note that the side effects are as follows:

• Feeling of nausea, sometimes with vomiting;
• Abdominal pain;
• Opening of internal bleeding;
• Flatulence;
• In rare cases, the development of hepatitis or jaundice;
• Dizziness and pain;
• Possible fainting, paresthesia and sleep disturbances, mental disorders.
• Decreased hearing and vision acuity;
• Development of renal failure;
• Kidney dysfunction;
• Heart failure.

If the components of the drug are taken seriously, patients may experience vaginal bleeding, it is possible that gynecomastia will develop, the appearance of menopausal symptoms (hot flashes followed by fever), and increased sweating. If significant side effects are detected, therapy should be stopped, and then go to the hospital, where the patient will be treated, and the doctor will select an analogue.

Analogues of the drug Indomethacin

The ointment has a number of analogues, the composition and action of which resemble or complement the action of Indomethacin:

1. Indovazin - ointment or gel, in addition to indomethacin, contains troxerutin - a venotonic, decongestant substance. Thus, Indovazin ointment reduces capillary permeability, perfectly strengthens the walls of blood vessels, and reduces tissue swelling. Effectively used for radiculitis, chronic and acute forms of polyarthritis, inflammation of the nerves, various joint injuries, dislocations, sprains. It perfectly relieves swelling after surgery, treats hematomas, as it improves blood microcirculation, thereby strengthening blood vessels.
2. Indobene is also an ointment or gel, has a similar pharmacological effect, and is more often used to treat injuries to tendons, ligaments, joint dislocations, sprains, and bruises. The ointment is effective in the treatment of osteoarthrosis, osteochondrosis, lumbago, shoulder-arm syndrome and some other similar diseases of the musculoskeletal system.

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There are several other drugs that have a similar therapeutic effect with the same symptoms of the disease - Indomethacin-Biosynthesis ointment, Indomethacin-Acri, Indotard, Metindol. All of them also have contraindications, since they all contain indomethacin and you need to be very careful when using these ointments.

But, the most important thing is not to let the disease progress and start treatment on time. As you know, prevention of treatment of any disease is much more effective and produces results faster than treatment itself. No wonder they say: movement is life. A joint disease that limits our movement, constrains our joints, and causes pain with every movement is a very serious problem leading to disability. A healthy lifestyle is the most important condition in the prevention and treatment of many diseases.

The use of Indomethacin suppositories in gynecology

In gynecology, suppositories with indomethacin are used for the following indications:

• Endometriosis and adenomyosis. Candles relieve pain and reduce inflammation.
• Ovarian cyst – slows down the growth of the tumor.
• Inflammation of the appendages – relieves pain and relieves inflammation.
• Inflammation of the ovaries, fallopian tubes - therapeutic effect.
• The likelihood of miscarriage - indomethacin suppositories are used only according to the indications of a specialist in the period from 16 to 32 weeks.
• Inflammation of the walls of the uterus - relieves pain and relieves inflammation.
• Fibroma – slows down tumor growth.
• Painful periods - relieve pain.
• Cystitis - relieve pain and inflammation, prescribed together with antibacterial drugs.
• Inflammation of the appendages – relieves pain and relieves inflammation.
• Myoma – slows tumor growth, relieves pain.
• Postoperative period – prevents the formation of adhesions.
• Painful menstruation – quickly relieves painful sensations;

Indications for the use of Indomethacin suppositories in gynecology:

• algodysmenorrhea (pain during menstruation): Indomethocin eliminates pain caused by the onset of menstruation;
• endometriosis and adenomyosis: with these diseases, in addition to pain, tissue is destroyed under the influence of inflammatory mediators. Indomethacin suppositories fight this scourge due to the fact that they have an anti-inflammatory effect;
• cystitis: Indomethacin suppositories in this case can be prescribed in conjunction with antibacterial therapy. they help reduce pain and inflammation, eliminating the unpleasant symptoms of cystitis;
• adnexitis (inflammation of the uterine appendages): anti-inflammatory and analgesic effect of the drug;
• ovarian cyst: Indomethacin helps relieve pain associated with cyst growth;
• Uterine fibroids: In some cases, Indomethacin helps slow tumor growth and relieve pain. With this disease, taking suppositories is possible only under the strict supervision of the attending physician.
• postoperative period: preventing the formation of adhesions
• threat of miscarriage (strictly from 16 to 32 weeks): strictly according to indications and under the supervision of the treating gynecologist. At a later date, Indomethacin suppositories may cause premature closure of the ductus botellus.

For any disease, suppositories with Indomethacin should be prescribed by your doctor, since there are a number of contraindications to their use. No more than 1-2 candles can be used per day. Thanks to this dosage of the drug, therapeutic concentrations in the blood are maintained.

In gynecological practice, suppositories with Indomethacin have found the widest use, because there is a wide range of diseases for which they are effective, since the development of these pathological processes occurs against the background of an imbalance of prostaglandins.

Indomethacin suppositories should be used with caution by women who have the following diseases: gastrointestinal bleeding, gastric and duodenal ulcers, ulcerative colitis, Crohn's disease, gastritis, proctitis, bleeding from the rectum of unknown origin.

In addition, contraindications for the use of Indomethacin suppositories in gynecology are the presence of epilepsy, parkinsonism, fractures, and impaired renal and hepatic function. The drug should not be used in the presence of hypertension, hypersensitivity to the drug and a tendency to bleeding.

There are much fewer contraindications for Indomethacin suppositories than for a similar drug that has a systemic effect, since Indomethacin in suppositories is practically not metabolized in the liver. This is also associated with increased activity when the drug is used rectally.

Therapy of osteochondrosis using the drug

Osteochondrosis, like most diseases, is characterized by interrelated symptoms, manifested in the form of pain, inflammation and swelling. Degenerative-dystrophic changes that occur against the background of osteochondrosis can lead to pinching of nerve endings. An inflammatory process occurs, swelling develops in the surrounding tissues, accompanied by severe pain. The result is partial or complete movement in the spine.

Treatment of such symptoms must be carried out with the help of medications that simultaneously have an analgesic and anti-inflammatory effect. Moreover, they should be selected not only for external use, but also for internal use.

The most effective drugs in the fight against acute inflammation are non-steroidal drugs. For local therapy, special gels and ointments are used. For example, Indomethacin-Biosynthesis ointment. Instructions for use and price are of interest to many. By itself.

A medicinal ointment containing the substance indomethacin is a complex remedy. When fighting osteochondrosis, it eliminates the three main symptoms of the disease: pain, swelling, inflammation. In addition, when using external products, there is a very low percentage of toxicity, as well as overall effects on the body. The product for external use allows you to achieve a cumulative, prolonged effect.

Contraindications

Like most medications, Indomethacin suppositories have certain contraindications. They are represented by diseases, as well as patient conditions, in which it is impossible to carry out therapy using this medication.

During pregnancy, suppositories are used under the supervision of a doctor.

Treatment does not allow in such situations:

1. Individual intolerance to the constituent components of the drug;
2. Pathologies or poor functioning of the kidneys and liver;
3. Third trimester of pregnancy;
4. Acute period of peptic ulcer;
5. Pathologies in which there is a dysfunction of the blood;
6. Allergy to aspirin and other anti-inflammatory drugs;
7. Optic nerve diseases;
8. The patient's age is less than 14 years.

It is unacceptable to administer suppositories rectally in the presence of bleeding from the rectum, diagnosed hemorrhoids and proctitis.

It is very important that therapy for elderly patients is carried out under strict medical supervision. The same applies to patients diagnosed with epilepsy or cardiovascular failure.

Strictly does not allow the intake of alcoholic beverages of varying strengths during the period of therapy, since the likelihood of negative reactions increases several times.

The drug Indomethacin, composition, purposes of use

This medicine can be produced in various forms (tablets, suppositories, ointments); there are conflicting opinions about its positive effects, since it gives strange consequences.

The first thing worth noting is that this remedy cannot be used without the recommendation and prescription of a doctor. The drug belongs to the group of NSAIDs, and is also a manufacturer of indoleacetic acid. Its actions are aimed at coping with the inflammatory process and reducing pain at the site of the lesion. Indomethacin tablets block the work of inflammatory agents and also reduce platelet aggregation. The active ingredient is indomethacin. In various forms of the drug, other excipients may be used.

Absorption is quite fast, the process of drug breakdown, its metabolism, takes place in the liver.

This medicine is used to improve the condition of a patient who suffers from pain syndromes of a rheumatic nature. But you should understand that it is not recommended to buy drugs from this group without a doctor’s prescription, as there may be side effects that contribute to deterioration of health. There are options for administration, both internally and externally. Depending on the diagnosis and personal tolerance, the doctor prescribes the best option; there are cases when the drug is used in several forms at once. The use of indomethacin can be prescribed for the following ailments:

• Neuralgia;
• Pain in the spine and other joints;
• Various types of traumatic inflammation.

These ailments cause serious pain; in such cases, a specialist may suggest indomethacin ointment for quick external use. If the patient has had surgical interventions, then in order to relieve inflammation, such a drug can be used (local application).

There are also a number of reasons why you will be prescribed an NSAID drug:

• Inflammation associated with joint deformation, various types of arthritis, about which we recommend reading in more detail;
• In cases of soft tissue damage, but only if it is rheumatic in nature;
• Prescribed in cases of complex therapy, but again, in order to relieve pain and inflammation itself.

Use during lactation and pregnancy

It is absolutely prohibited to use Indomethacin during breastfeeding, because very often the active substances pass into breast milk.

The absorption of the drug is very strong, so it is best to avoid it during pregnancy, especially in the first 16 weeks, when the fetus is just beginning to form.

Doctors prescribe it for use only when the positive effect from it greatly exceeds the side effects. Basically, this is done only in the 3rd trimester.

Instructions for use

Indomethacin tablets are prescribed exclusively for oral administration at the indicated dosage. It is not recommended to chew them or crush them in other ways. The maximum daily dosage is 200 mg, but usually therapy begins with a minimum dose of 50 mg. If this is not enough, it is increased.

It is strongly not recommended to increase the dose on your own. The tablets should be taken during or immediately after meals. Do not use on an empty stomach in order to prevent negative reactions from the digestive tract. The duration of treatment depends on the severity of clinical manifestations and concomitant pathologies. As a rule, 10 days are enough, but in some cases the medicine is taken for up to 3-4 weeks, provided there are no contraindications or adverse reactions.

Ointment and gel are used externally to treat sore joints or bruises. It is necessary to apply a thin layer, do not rub vigorously. Use no more than 3 times a day. To achieve maximum therapeutic results, treatment is recommended for 10-14 days. Longer use may cause complications.

Suppositories are used only rectally. There is an opinion that the product can be inserted into the vagina, but the instructions prohibit this. Such experiments can provoke severe complications of the mucous membranes. The daily norm is 1 suppository. It is recommended to administer in a lying position to a depth of at least 2 cm. This promotes rapid absorption of the drug.

The best time to administer a suppository is before bed. The duration of the course depends on the patient's condition. Doctors do not recommend using suppositories for longer than 7 days. A longer course will certainly lead to complications and adverse reactions. You should also not increase the dosage on your own. If the daily dose does not help relieve pain and associated symptoms, it is worth consulting with a specialist about the advisability of using other dosage forms.

When taking the tablet form of the medication, the active substance is quickly absorbed into the digestive tract. Already 2 hours after consumption, the maximum concentration of indomethacin is observed in the plasma. This explains its speed. Metabolism occurs in the liver, where the component is converted into inactive breakdown products. The removal period of the ointment or gel takes up to 10 hours. The medicine does not accumulate in tissues. It is excreted in greater quantities in urine and in smaller quantities in feces.

When using rectal suppositories, the period of absorption and processing is slightly reduced. 30 minutes after administration, the maximum concentration of the substance in the blood is observed, and the therapeutic effect is observed within 15 minutes after administration. The use of the external form of the drug also ensures rapid action.

Reviews

Quite often, Indomethacin suppositories are prescribed in gynecology (rectally and vaginally). Reviews about this drug can be found both from doctors and from women who were treated. In most cases, girls note a good therapeutic effect, regardless of what pathology was treated.

The medicine has practically no side effects, copes well with eliminating uterine hypertonicity, and also allows you to get rid of algodismenorrhea. However, it is not recommended to carry out therapy on your own, determining the duration and daily dosage, as this may negatively affect your overall health.

Analogues in structure

Today there are a huge number of indomethacin analogues. It is produced in Russia, Bulgaria, Italy. Almost all manufacturers offer various forms - from solutions to ointments. The only exception is indomethacin, used in ophthalmology - it is produced strictly in the form of drops or suspension.

Modern suppositories and ointments based on this substance differ not only in name and country of origin, but also in price. What analogues of indomethacin are most often found in pharmacies? We are talking about the following medications:

• Indomethacin Sopharma.
• Indomethacin Berlin Chemie.
• Indomethacin-Altpharma.
• Indomethacin Biosynthesis.
• Indobene.
• Methindol.

Which drug should be preferred? Are there any fundamental differences between them?

Similarities and differences

All these medicines have the same effect; they can differ only in price, quantity and dosage of suppositories in the package and the weight of the ointment.

The most expensive are indomethacin suppositories and ointment from the Berlin Hemi company, jointly produced in Italy and Germany. This is due both to the well-known brand and to the quality and reliability of the drug itself. All Berlin Hemi products are protected from counterfeiting.

Methindol is a drug that is produced in Poland. It can also be classified as an expensive analogue of indomethacin. The price of Methindol varies significantly in different pharmacy chains.

Indomethacin from Sopharma, Bulgaria is in the middle price category. The cost of tablets, ointments and rectal suppositories is lower than Berlin Hemi products, but higher than their Russian counterparts.

Indomethacin from Altpharma and Biosintez companies is produced in Russia. This is due to its low cost. But it’s not always cheap – it’s of poor quality. The drug is well tolerated, is available in all dosage forms - tablets, suppositories, ointments, and does not have any special side effects.

Indobene is a drug from an Austrian company. Available in the form of tablets, dragees, rectal suppositories. The local form is not an ointment, like other manufacturers, but a gel. The gel structure allows indomethacin to be quickly and easily absorbed through the skin without leaving any traces.

But what if indomethacin is not available in pharmacies in any form or if an allergic reaction or intolerance occurs to it? Is it possible to replace this medicine with a similar effect?

Interaction with other drugs

The Berlin-Chemie company produces Indomethacin suppositories in 2 dosages: 50 and 100 mg in the form of white suppositories with a yellowish or creamy tint. They are rectal and vaginal. They have an easy-to-use torpedo-shaped shape and have a weak specific odor.

https://www.youtube.com/watch?v=ytpressde

Preparations with this dosage are sold in cardboard packs containing packages with contour cells, each of which contains 5 suppositories. In total, a pack can contain 2, 6 or 10 packages with cells.

Average price from 80 to 250 rubles.

The drug consists of 50 mg or 100 mg of indomethacin as the active substance and auxiliary components - solid fat and corn starch.

Before using suppositories, you should consult a doctor, since the drug has properties that negatively affect other medications, or you experience the negative effects of some of them on yourself when used simultaneously.

The use of suppositories with indomethacin creates the following effects in combination with:

• Methotrexate, cyclosporine, zinovudine - increases their toxicity
• Probenecid - increases its concentration in blood plasma
• Diflunisal - creates a risk of significant bleeding in the gastrointestinal tract
• Digoxin, lithium, penicillin - increases their content in the blood
• Ethanol, colchicine, glucocorticosteroids - creates a risk of gastrointestinal complications (diarrhea, nausea, vomiting, inflammation in the gastrointestinal tract) with bleeding
• Saluretics (diuretics) - makes them less effective
• Paracetamol, gold preparations, cyclosporine - increases the likelihood of developing the nephrotoxic effect of indomethacin (kidney damage)
• Cefamandole, valproic acid, cefoperazone - causes bleeding disorders
• Diuretics (diuretics that do not remove potassium) - increases the risk of hyperkalemia (abnormal concentration of potassium in the blood), which can lead to paralysis and threaten cardiac arrest.

The use of Indomethacin suppositories can cause a number of side effects associated with disorders in all systems of the human body.

• Digestive system: attacks of nausea, vomiting, dry mouth, decreased appetite, heartburn, thirst, increased bilirubin in the blood, gastric disorders. Long-term use of suppositories in large doses leads to the appearance of ulcers of the gastrointestinal mucosa.
• Nervous system: dizziness, poor sleep, irritation, headaches, leg cramps, apathy, lethargy, drowsiness, confusion.
• Cardiovascular system: arrhythmia, heart failure, high blood pressure, tachycardia.
• Urinary system: kidney failure, nephrotic syndrome, decreased potency.
• Sense organs: decreased vision, hearing, impaired taste.
• Hemostasis system: bleeding of various locations (gastrointestinal tract, hemorrhoidal, gingival, uterine).
• Hematopoietic system: anemia, leukopenia.
• Water-electrolyte metabolism: dehydration, imbalance of acids and alkalis in the body, hyperkalemia.
• Allergic reactions: Quincke's edema, skin rashes, bronchospasms. Sometimes - anaphylactic shock.
• Metabolism: decreased levels of chlorine and sugar in the blood with dizziness, thirst, arrhythmia, convulsions, the appearance of glucose in the urine.
• Other: edema syndrome, increased sweating, acute hemorrhoids, aseptic meningitis.

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The active substance of the drug is the non-steroidal drug indomethacin. It has an anesthetic, antipyretic, anti-inflammatory effect. Thanks to its use, the patient’s attacks of pain are relieved, fever goes away, and inflammation is reduced.

When administered rectally, the suppositories melt under the influence of the heat of the human body, indomethacin is released and absorbed into the walls of the rectum. The effectiveness of the drug is explained by its direct entry into the blood (bypassing the stomach and intestines, as when taking tablets).

The active component of this medicine can cause serious side effects, such as internal bleeding, so suppositories containing indomethacin are not prescribed for hemorrhoids. An allergic reaction in the form of bronchospasms, urticaria, and angioedema can occur in asthmatics and people sensitive to allergens. Other side effects of indomethacin suppositories:

• increased blood pressure;
• insomnia;
• headache;
• diarrhea;
• drowsiness;
• noise in ears;
• irritability;
• hallucinations;
• dizziness.

Attention! The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and give treatment recommendations based on the individual characteristics of a particular patient.

Complications and consequences

Typically, Indomethacin gel is well tolerated by patients. Rarely, side effects may occur:

• Allergic reactions in the form of urticaria, which is accompanied by itching.
• Dermatitis.
• Headache.
• Asthma attack, which can lead to shortness of breath.
• Nausea accompanied by vomiting.
• Swelling.
• Anaphylactic shock.
• Quincke's edema.

If negative symptoms occur, you should immediately consult a doctor.

Action of the drug

According to the instructions for use and reviews, Indomethacin gel has anti-inflammatory, angioprotective, analgesic, capillary stabilizing, and anti-edematous effects. After its application, pain is eliminated, swelling is reduced, regeneration of damaged tissues and joints is accelerated, capillary fragility is reduced, and blood supply to tissues in case of venous insufficiency is improved.

The active components of the drug block the synthesis of prostaglandins.

Video about indomethacin suppositories

Method of using indomethacin suppositories:

The body has a terrible reaction to indomethacin. Can it be replaced with Diclofenac? Or what other NSAIDs can be used instead??

I think that when you see a doctor, you will be given similar drugs that will not cause allergies. It all depends on the disease for which Indomethacin is prescribed. For example, Naproxen, Ketoprofen, Diclofenac have the same analgesic and anti-inflammatory effect.

But these drugs also have contraindications, so you need to consult a doctor; self-medication can only do harm.

The anti-inflammatory drug Indomethacin is often used to treat various pathological processes of the joints. The pharmaceutical agent directly affects the inflammatory focus, eliminating painful symptoms and improving the patient’s well-being. However, it should be taken into account that the medicine is used as an adjuvant in combination with drugs, the main purpose of which will be the treatment of damaged joints.

What are Indomethacin tablets

Being an anti-inflammatory drug that reduces temperature and prevents the formation of blood clots, Indomethacin tablets are used to suppress inflammatory foci in the body, the growth of serous exudates and reduce the proliferation of tissues characteristic of inflammation of various etiologies. Being used to relieve rheumatic joint pain, the drug Indomethacin not only relieves severe pain, but also helps reduce the volume of edema and tumors. This action returns patients to their previous quality of life.

However, you should not try to treat various ailments on your own using only these pills. Doctors prescribe the drug Indomethacin to patients as an adjunct to the main treatment, which consists of drugs that have a selective effect on the cause of the disease. If you “numb” the pain with Indomethacin tablets for a long period of time without contacting a specialist, then there is a possibility of additional diseases occurring, since the drug has an extensive list of side effects.

Indomethacin rectal suppositories for prostatitis, hemorrhoids and gynecological diseases

The study, published in an issue of the Chinese Journal of Andrology, examined the effects of indomethacin suppositories and the antidepressant trazodone in a group of 60 patients with chronic prostatitis.

Treatment was carried out for 8 weeks. All patients showed a decrease in scores on the chronic prostatitis symptom scale, and the number of side effects was low.

Study Finding: The therapeutic alliance of indomethacin suppositories and trazodone is safe and effective and may help relieve symptoms of prostatitis and may also improve sperm quality and sexual function. However, further research is needed.

For acute or chronic prostatitis, 1 suppository (100 mg) is usually prescribed twice a day. The urologist will give an exact dosage recommendation. Through the venous plexus in the rectum, the active component is quickly absorbed into the blood and reduces swelling and spasms in the prostate gland, relieves pain in the lower abdomen.

Reviews on forums and websites about the use of Indomethacin for prostatitis are mostly positive. It is praised for its convenient packaging, quick pain relief, and small size. There are complaints of burning in the anus, abdominal pain and dizziness, but these are common side effects of this drug and do not require its discontinuation.

Indomethacin: rectal suppositories in gynecology

• Uncomfortable and painful sensations during menstruation (algodysmenorrhea). A very common phenomenon that women encounter before their first birth, and sometimes even before menopause. The growth of endometrial cells beyond its boundaries (endometriosis) is a condition that can cause severe pain and inflammation. Indomethacin successfully combats both problems. Cystitis - suppositories are used together with drug therapy. Inflammation of the uterine appendages (adnexitis) – as part of complex therapy. A benign neoplasm of the uterus (fibroleiomyoma) is sensitive to indomethacin and slows down its growth when suppositories are used.

Indomethacin rectal suppositories should be used only under the supervision of a gynecologist, as they have many contraindications. The daily dose is no more than 200 mg per day.

Indomethacin: rectal suppositories for hemorrhoids

In accordance with the instructions, use 1 rectal suppository with indomethacin in the morning and at night. Suppositories fight inflammation characteristic of this disease, have rapid analgesic and antipyretic effects and prevent the formation of blood clots.

The course of treatment is from 3 to 10 days. If there is bleeding from the rectum, suppositories should not be used.

Instead of indomethacin suppositories, your doctor may recommend using Diclofenac, Naproxen or Ketaprofen suppositories. They also belong to non-steroidal anti-inflammatory drugs and have antipyretic and analgesic properties. Those who specifically need suppositories with indomethacin can purchase Metindol.

Drug analogues

Sometimes the use of the original drug is impossible for one reason or another, so it is necessary to find a suitable substitute with similar pharmacological properties. The most popular analogues are the following:

1. Ibuprofen is the most popular and effective substitute, which contains the active ingredient of the same name. It has a pronounced analgesic, antipyretic and anti-inflammatory effect. Available in the form of tablets, gel, suppositories, ointments. The advantage of the medicine will be the presence of a special release form - a suspension for children. This allows it to be used not only by adults, but also by babies from 3 months. The drug is not prescribed for peptic ulcers, allergies, aspirin-induced asthma, or during pregnancy and lactation.
2. Diclofenac also belongs to the group of non-steroidal anti-inflammatory drugs. It has several forms of release: tablets, suppositories, ointment, gel, solution for intramuscular injection. It has a good effect and is often used as an adjuvant in the treatment of inflammatory pathologies of organs and systems. Not used for the treatment of pregnant and lactating women, children under 14 years of age, patients with severe pathologies of the kidneys, liver, or allergies to the components of the composition.
3. The drug Naklofen also contains diclofenac, due to which it has a therapeutic effect. Available in tablet and injection form, as well as suppositories and gel for external use. The medicine helps relieve acute pain, slow down the progression of the inflammatory process, and eliminate hyperthermia. It is prescribed in short courses of 5-7 days, as it often provokes complications. The advantage of the medicine will be the ability to prescribe a solution for drip infusions. This use option helps provide emergency assistance in case of severe pain.

Any of the drug analogues has similar properties and effects on the body, but this does not allow it to be used independently and without prior examination.

Analogues in action

Since indomethacin is a NSAID, in fact, any drug from this group can be considered its analogue. But in practice everything is a little more complicated.

NSAIDs are divided into groups depending on their chemical structure, duration and direction of action. The last point is especially important when selecting optimal therapy. All NSAIDs have three effects:

• anti-inflammatory;
• antipyretic;
• anesthetic.

Pharmacological properties

The main component of the pharmacological agent belongs to the group of non-steroidal anti-inflammatory drugs and has a pronounced therapeutic effect. Its effectiveness is explained by its inhibitory effect on the enzyme cyclooxygenase. This substance stimulates the production of prostaglandins, which become the main cause of the development of the inflammatory process.

When the synthesis of cyclooxygenase is suppressed, prostaglandins stop entering the systemic circulation, the progression of the pathological process slows down, and the patient’s condition significantly improves.

In addition, the drug has a pronounced analgesic property, and also relieves general and local hyperthermia. Pain is eliminated by reducing swelling, reducing capillary permeability and strengthening the vascular wall. The medicine also affects substances that provoke a persistent increase in body temperature. There is evidence of the effect of the active component on cell metabolism. It helps restore their normal functioning, improves the protective properties of membranes and prevents destruction.

For patients with pathologies of the musculoskeletal system, this pharmacological agent is indispensable. It helps eliminate pronounced clinical manifestations, relieves swelling and reduces the time of morning stiffness, which is often observed with inflammatory and degenerative changes in bone and cartilage tissue.

The medication prevents the formation of blood clots by inhibiting the process of platelet adhesion and thins the blood, facilitating its movement through the vessels to the site of inflammation. Thanks to the complex effect, complete and partial recovery in chronic pathology is possible.

Indications and contraindications

Instructions for the use of Indomethacin ointment and other dosage forms suggest their prescription only after a thorough examination and identification of the cause of the disorder.

The medicine is used in the following cases:

1. neuritis and neuralgia of varying severity;
2. chronic gout with frequent relapses;
3. arthritis of rheumatoid and infectious etiology;
4. arthrosis with damage to the knee and hip joints, as well as deformation of the limbs;
5. spondylitis, advanced osteochondrosis;
6. chronic radiculitis with frequent attacks and irradiation of pain to the lower extremities;
7. myalgia and joint pain of unspecified etiology;
8. bruises, sprains, ruptures of tendons and ligaments;
9. post-traumatic pain syndrome;
10. prostatitis in the acute stage;
11. urethritis and cystitis;
12. pyelonephritis, glomerulonephritis at different stages;
13. intervertebral hernia with severe pain;
14. pinched nerve endings due to displacement of the vertebrae;
15. fever due to colds and viral pathologies;
16. severe bursitis without suppuration in the joint capsule.

Instructions for the use of Indomethacin suppositories in gynecology suggest their use for colpitis, adnexitis, menstrual irregularities and other pathologies. The drug is also allowed to be used for symptomatic therapy for diseases of the ENT organs of an inflammatory nature.

Main contraindications:

• hypersensitivity to the components of the drug or tendency to allergic manifestations;
• period of bearing a baby and breastfeeding;
• children up to 14 years of age (external forms up to 6 years);
• liver cirrhosis, liver failure;
• chronic renal failure;
• bleeding disorders due to decreased platelet levels;
• internal bleeding of varying etiology and severity;
• acute pancreatitis;
• peptic ulcer with threat of perforation of the stomach wall;
• bronchial and aspirin-induced asthma with frequent attacks;
• acute period of myocardial infarction;
• chronic, acute colitis or enteritis;
• recovery period after surgery on the coronary vessels;
• severe anemia;
• gastritis with increased acidity of gastric juice;
• congenital heart defects;
• hemorrhoids, proctitis, anal fissures and bleeding from the anus.

• hypersensitivity to the components of the drug or tendency to allergic manifestations;
• period of bearing a baby and breastfeeding;
• children up to 14 years of age (external forms up to 6 years);
• liver cirrhosis, liver failure;
• chronic renal failure;
• bleeding disorders due to decreased platelet levels;
• internal bleeding of varying etiology and severity;
• acute pancreatitis;
• peptic ulcer with threat of perforation of the stomach wall;
• bronchial and aspirin-induced asthma with frequent attacks;
• acute period of myocardial infarction;
• chronic, acute colitis or enteritis;
• recovery period after surgery on the coronary vessels;
• severe anemia;
• gastritis with increased acidity of gastric juice;
• congenital heart defects;
• hemorrhoids, proctitis, anal fissures and bleeding from the anus.

External forms of the drug are prescribed with extreme caution when the integrity of the skin is damaged. It is prohibited to treat the wound surface directly. Relative contraindications include old age, heart failure, coronary heart disease, epilepsy, diabetes mellitus, severe arterial hypertension, and peripheral vascular damage.

It is forbidden to take the medicine simultaneously with other NSAIDs, anticoagulants and hormonal drugs. These drugs increase the toxic effect on the liver and increase the negative impact on the organs of the digestive system.

For parkinsonism, epilepsy and chronic alcoholism, you should also refrain from taking the medicine. You should not combine the drug with Paracetamol and products that contain it, since such a mixture increases the toxic effect on the kidneys several times.

If the patient is taking antacid medications, the absorption of indomethacin is significantly slowed down. The drug reduces the effectiveness of diuretics and antihypertensive medications. External forms should not be used simultaneously with other medications from the same group, since the risk of developing an allergic reaction significantly increases.

Side effects

If recommendations are not followed, patients often develop adverse reactions from organs and systems. The first symptom will be pain in the stomach, indigestion, nausea, vomiting, flatulence, bloating, heartburn, frequent loose stools or persistent constipation, decreased or complete lack of appetite.

In severe cases, chronic gastrointestinal pathologies worsen in patients. If there were no symptoms before treatment, gastritis, liver failure, colitis and other diseases associated with taking the medication may develop.

Negative reactions are observed from the central nervous system: headache, weakness, dizziness, drowsiness, disturbance of psycho-emotional balance, depression, decreased concentration and mental performance, memory impairment. Sometimes vision temporarily deteriorates, dark spots and spots appear before the eyes, and ringing in the ears.

Some patients experience damage to the mucous membranes of the oral cavity. Small ulcers appear on them, which can bleed. This makes it difficult to eat, and the patient’s weight decreases. In advanced cases, a severe form of anorexia may develop. In this case, restoration of metabolism is significantly complicated.

Patients with a bleeding tendency often experience bleeding gums or gastrointestinal bleeding. In severe cases, consciousness is impaired, convulsions begin, and blood pressure drops to critical levels.

The allergic reaction manifests itself sharply and is accompanied by a rash, hyperemia, swelling, peeling, itching and irritation of the epidermis. In advanced cases, symptoms of Quincke's edema or urticaria appear.

When using rectal suppositories for a long period, a person may experience signs of irritation of the rectal mucosa, as well as bleeding from the anus.

If the complications are mild, it is enough to stop taking the medicine to eliminate them. If they worsen, it is necessary to urgently seek qualified help.

Release forms, how to use the drug correctly

This medicine, as mentioned above, can be released in different forms, this is necessary so that the doctor can select a high-quality course of treatment for the patient, directions for eliminating pain and inflammation in the immediate localization. Prices for such a drug may vary, depending on what you buy - ointment or tablets. But you should understand that if you are prescribed pills, you do not need to replace them with something else.

Today, the following forms of drug release can be distinguished:

• Eye drops. They are rarely prescribed, but they do occur. Their price is approximately 200-220 rubles;
• Indomethacin suppositories. They can be prescribed in cases of severe pain in the spine, with severe inflammation of soft tissues (under conditions of a traumatic nature), with pain in the joints;
• Tablets/dragés. The most common treatment option. It is in this form that the doctor prescribes this drug. But there is another opinion here that it is better to use suppositories or ointments for a quick effect of eliminating pain and inflammation. It is better to use tablets in a complex treatment method, then the effect will be 100%. The issue price is 30-45 rubles;
• Capsules. Similar to tablets. They are prescribed, but it is better to do it in combination. They have an advantage over tablets - they dissolve quickly;
• Ointment. Used in cases of severe pain in the joints and back. The ointment is applied to the affected area. The effect occurs after a minimum amount of time. Should be used as prescribed by a doctor.

There can’t even be any talk of self-medication with such a drug. Therefore, the specialist himself will prescribe a course of treatment for you and determine the dosage. Instructions for use of Indomethacin are attached to any release form, but it is better to take the drug based on the instructions prescribed by your doctor:

1. Pills. Their quantity and duration of use depend on the severity of the disease. In general, an adult should take about 25 mg of this substance, and then split it into 2-3 doses. It is possible to increase the dosage up to 50 mg. After 4 weeks of treatment, if the outcome is positive, the dosage begins to be reduced. In no case should you exceed 75 mg of the drug per day. Since the drug is quite serious, it should not be taken on an empty stomach; use it after meals;
2. The use of Indomethacin suppositories is prescribed for severe back pain. It is worth understanding that the drug enters the body through the rectum, so it is worth emptying the intestines before directly using the drug. Most often, an adult is prescribed only 100 mg of the drug, 1 suppository. The option is two times 50 mg. If it is more acute, they can increase the dosage, up to 200 mg;
3. Injections. They will be used in the most serious forms of the disease. Prescribed 60 mg, administered intramuscularly. This course of treatment lasts about 2 weeks, while the injection itself is given once every 1-2 days.

Prices of candles in pharmacies

The price of indomethacin suppositories depends on the manufacturer and dosage of the drug.

The average cost of a package of suppositories of 50 mg of active ingredient is:

• 90 rub. pharmaceutical, Russia (10 candles);
• 70 rub. pharmaceutical company "Sopharma", Bulgaria (package contains 6 suppositories);
• 280 rub. pharmaceutical, Germany (10 candles).

The average price of indomethicin in suppositories with a dosage of 100 mg is:

• 120 rub. "Altfarm", Russia (10 pieces per package);
• 100 rub. “Sopharma”, Bulgaria (pack of 6 pcs.);
• 360 rub. "BERLIN-CHEMIE, Germany (10 pieces per pack).

The purchase of the drug is carried out according to a prescription from the attending physician. The medicine should not be used after the expiration date.

Indomethacin suppositories are an effective drug for the treatment of gynecological diseases. Take the medicine only as prescribed by the gynecologist, taking into account the existing contraindications and side effects indicated in the instructions.

Article design: Vladimir the Great

Indomethacin price

The medication is sold in pharmacies at prices that depend on the pricing policy, release form, and pack size. In Moscow the cost will be:

Type of drug release	Manufacturer	Price, rubles
Tablets 25 mg 30 pcs.	Ozone	27
	Sopharma	56
Ointment 10% 40 g		80
Ointment 10% 30 g	Biosynthesis	59
Rectal suppositories 100 mg 10 pcs.	Berlin-Chemie	378
	Biosynthesis	74
Suppositories 50 mg 5 pcs.	Sopharma	80

Use in childhood

Indomethacin in any pharmacological forms is not prescribed for children under 14 years of age.

Elderly age

People try not to prescribe this dosage form in old age. Since it can provoke an exacerbation of old chronic processes and cause unpredictable side effects.

Most often, when this drug is prescribed, it is used in tablet form. This is due to the fact that when they are taken, the effect occurs smoothly.

Suppositories, bypassing the stomach, immediately enter the bloodstream and have an almost instant effect. But for older people this is unacceptable.

Indomethacin suppositories for prostatitis: special instructions, cost, analogues, reviews

It is necessary to understand what an analogue of this drug is. Pharmaceutical manufacturers and doctors use this name to mean drugs that are similar in chemical structure and composition.

But the correct name for these dosage forms will be considered generics, or synonyms (pharmacological copies of the drug).

Substitutes include medicinal substances that have identical effects. They may belong to the same or different pharmacological groups, be monocomponent, or combined with other dosage forms.

They may also have different chemical structures.

The most common, accessible analogues can be considered:

• Methindol. Produced in Poland. It is considered an expensive analogue of Indomethacin suppositories. The average price ranges from 150 to 200 rubles.
• Indomethacin suppositories from Sopharma are produced in Bulgaria and have a relatively cheap price from 85 to 100 rubles.
• Indomethacin in various dosage forms is produced in Russia by Altpharma. Its main advantage is that it is well tolerated by patients; it does not have many contraindications and side effects. The average price of suppositories does not exceed 120 rubles. for 10 pieces, dosage of 100 milligrams.
• Indobene. Produced in Austria, it has a relatively low price, up to 200 rubles.

Methindol Indomethacin Sopharma Indomethacin Altfarm Indobene
These analogues are very similar in chemical structure, their main component is Indomethacin.

If individual intolerance to it occurs, or an allergic reaction develops, this means that this drug must be replaced with an analogue that will be comparable in action to Indomethacin.

Such medications include:

• Ibuprofen. Manufacturer: Darnitsa. It has become widespread in the treatment of not only adults, but also children. Available in various dosage forms. The number of side effects is much lower than that of other similar drugs. The average price does not exceed 100 rubles.
• Butadion. A very once popular drug, but due to the fact that it has a lot of side effects, it is not prescribed so often at this time
• Diclofenac. Rectal forms of this drug are very well tolerated by patients and have a minimum of side effects. The average price can range from 10 to 20 rubles. Suppositories containing Diclofenac are sold in pharmacies under the name Dicloberl or Diclovit. They are very similar in pharmacological action, but differ in price.

Despite the fact that Indomethacin suppositories have many analogues, it should be remembered that they all have side effects and contraindications. This is why you should not engage in individual selection and prescribe your own medicine. To do this, you need to go to the clinic.

At the moment, analogues of indomethacin suppositories are available in pharmacies. Their cost varies and depends on the number of suppositories in the package and milligrams. Analogues of the drug include:

• Ketoprofen;
• Naproxen;
• Movimed;
• Diclofenac;
• Indobene;
• Methindol.

All of the listed analogues have the same effect as Indomethacin, but before use, be sure to read the instructions. Analogs may cost less, but before purchasing, you should make sure that the drug contains the required amount of active ingredient. The price of medicines depends on the manufacturer; for example, a drug from a foreign representative will cost more than a local one.

If for some reason it is impossible to use Indomethacin suppositories, then the doctor may recommend a replacement drug - both in the form of suppositories and in another form.

You can purchase this non-steroidal anti-inflammatory drug, which is a derivative of indoleacetic acid, at any pharmacy. The average cost of Indomethacin suppositories for prostatitis is 70 rubles. The medicine is dispensed strictly according to the doctor's prescription.

In order for the medicine to retain its medicinal properties longer and not deteriorate ahead of time, it must be stored correctly - at a temperature of 25 degrees. The product can be stored for three years.

This remedy is one of the most effective, as it has anti-inflammatory and analgesic, antipyretic and anti-edematous properties. Indomethacin suppositories for prostatitis will quickly relieve unpleasant symptoms, especially inflammation, pain and swelling, and will also help improve your well-being and condition. The remedy takes effect approximately a quarter of an hour after the suppository is inserted into the rectum.

DETAILS: Gynecology and urology in Moscow

A drug	Compound	Price, rubles
Amelotex	Meloxicam	200
Diclofenac	Diclofenac	105
Flexen	Ketoprofen	190
Ibuprofen	Ibuprofen	110
Voltaren	Diclofenac	340
Ketonal	Ketoprofen	280

The drug must be used very carefully in older people - the risk of side effects is much higher. Allergic reactions to this product are often observed; people with a tendency to allergies should also be careful. Indomethacin should not be combined with other NSAIDs in simultaneous use, as this increases the risk of bleeding and gastrointestinal ulcers.

Patient reviews, drug prices

The use of this medicine leaves positive feedback from patients. More often than others, rapid pain relief is observed, as well as a return to normal life already on the 5-7th day of using indomethacin. You can read more about the reviews on the use of this medicine below.

The drug in question is very effective for various diseases, but it should be taken only after consultation with a specialist doctor.

Indomethacin Berlin Chemi is a fairly affordable drug. In city pharmacies it can be found at a price of 200-250 rubles. The price depends on the pharmacy itself, as well as on the manufacturer. Sold without a prescription.

Reviews:

• Ivan Nikolaevich, 56 years old. Reviews of the ointment from my friends are positive. But I didn’t buy it because I didn’t have a doctor’s prescription. At the pharmacy, I was also advised to buy ointment to relieve back pain. Bought. After applying the ointment 3 times, I felt relief. I use it only according to the instructions.
• Oleg, 23 years old. I know what the drug helps with, but I haven’t bought it myself. After I started playing sports, frequent injuries forced me to see a doctor, I was prescribed Indomethacin for external use. I was surprised that its effect was instantaneous. Now, in cases of severe knee or back pain, I use this ointment, but only on the recommendation of a doctor.

Doses, duration of treatment

Indomethacin in tablet form is recommended to be taken after meals. The exact dosage is selected individually, taking into account the course of the pathological process and the severity of symptoms. The initial dose of the drug generally starts with 25 mg three times a day (in adults), then, taking into account susceptibility, the daily dosage is increased to 100 mg per day (3 doses).

When treating gout, it is recommended to take Indomethacin in the following doses:

• Acute attacks - 0.05 g of medication 3 times a day.
• Preventing the formation of exacerbations - 0.025 g 2 times a day.

The highest daily dose is 200 mg.

When the desired therapeutic effect is achieved, Indomethacin therapy continues for a month at the same or reduced dose. With prolonged use, the daily dosage cannot be higher than 75 mg.

Injections. To eliminate acute manifestations or relieve chronic processes, the drug is administered intramuscularly at a dose of 60 mg up to 2 times a day. The duration of such therapy is 1-2 weeks. Subsequent treatment is carried out using tablets or suppositories.

Suppositories. Used for exacerbation of chronic processes or acute conditions. In such a situation, the usual dose is 1 suppository twice a day. It is necessary to monitor that the maximum daily dosage does not exceed 0.2 g. As maintenance therapy, suppositories of 0.05-0.1 g are used 1 time before bedtime. The suppository is administered after natural bowel movement deep into the anus.

Ointment. In accordance with the instructions, the product is applied to the damaged part in a small layer. During the day, it is forbidden to increase the maximum dose - up to 15 cm of the drug, which is squeezed out of the tube. For children, the largest amount of Indomethacin does not exceed 7 cm. The medicine is mainly used for a long time. Early cessation of use can return negative symptoms. The duration of therapy depends on the course of the pathological process.

Pregnancy and lactation

Indomethacin may cause disturbances in fetal development, blockage of the arterial ducts, myocardial insufficiency, bleeding due to a decrease in the number of platelets in the bloodstream, kidney dysfunction, difficulty in labor or premature birth. Based on the above facts, indomethacin tablets are prohibited for use during late pregnancy and breastfeeding. During the first two trimesters, the drug is prescribed only when absolutely necessary.

Release forms

Indomethacin is available in several pharmacological forms (tablets, suppositories, ointments). First of all, it is forbidden to use the drug without the consent of a specialist. The medicine is classified as a non-steroidal anti-inflammatory drug. Its effect is aimed at eliminating inflammation and reducing pain in the affected area.

Pills

The number and duration of use of tablets varies depending on the severity of the disease. Mostly, they are produced in 30 and 60 pcs. packaged. Covered with an enteric coating. Quickly absorbed by the body. Before taking, you must carefully read the instructions for the drug.

For joint diseases, Indomethacin ointment is used for application or rubbing into the affected area. Contains a 10% concentration of the active substance. It also contains auxiliary elements: cholesterol, stearyl alcohol, dimethyl sulfoxide, bronopol, lanolin, white petroleum jelly. In tubes of 30 or 40 g, in a cardboard pack 1 tube.

Indomethacin eye drops are an effective medication widely used in ophthalmology to achieve analgesic and anti-inflammatory effects. The medicine is effective for infections and eye injuries. Pack contains 5 ml. The content of the main active component indomethacin is 0.1%.

Suppositories

Rectal suppositories have been used in medical practice for quite a long time; they have a number of positive qualities needed in the treatment of pathological processes in the spine and joints. Suppositories are available in 50 mg and 100 mg. There are up to 10 suppositories in a package. In addition to the main component Indomethacin, the medicine contains excipients: silicon dioxide, castor oil, solid fat, urea, polysorbate.

Like any drug, Indomethacin suppositories have side effects.

1. Digestive system:

• Nausea, vomiting
• Heartburn
• Gas formation
• Anorexia
• Diarrhea
• Liver disorders
• Abdominal pain
• Irritation of the intestinal mucosa

2. Nervous system:

• Dizziness, headaches
• Insomnia
• Irritability
• Fatigue
• Drowsiness
• Depressive state

3. Cardiovascular system:

• Increased blood pressure
• Tachyarrhythmia
• Heart failure

4. Urinary system:

• Kidney dysfunction
• Proteinuria
• Hematuria
• Interstitial nephritis
• Nephrotic syndrome
• Necrosis of the papillae

5. Sense organs:

• Hearing loss
• Noise in ears
• Impaired taste sensitivity
• Visual impairment
• Conjunctivitis

6. Allergic reactions:

• Skin rash
• Itching
• Hives
• Quincke's edema
• Bronchospasm
• Anaphylactic shock

7. Local reactions:

• Itching
• Burning
• Exacerbation of hemorrhoids

An overdose of Indomethacin suppositories may cause nausea, vomiting, headache, dizziness, memory impairment, disorientation, and, in severe cases, the drug can cause convulsions and numbness of the limbs.

As you can see, the drug has a lot of contraindications, therefore, in order to avoid complications, it should be used strictly as prescribed by the attending physician.

While using indomethacin suppositories, you should avoid driving a car and other types of work that require increased concentration.

When interacting with other drugs, indomethacin can reduce the effect of drugs, increase toxic effects on internal organs, and also increase the risk of developing diseases and complications, therefore, this should be taken into account when prescribing indomethacin.

Indomethacin

Indomethacin is a derivative of indoleacetic acid. It has pronounced anti-inflammatory activity and is a strong NSAID. The main indications for prescribing indomethacin:

Indomethacin is available in various forms - tablets, injections, ointments, suppositories. The choice of dosage form is determined by the localization of the process, tolerability of the drug and the presence of other diseases in the patient.

Suppositories and ointment are considered the safest. Indomethacin tablets are irritating to the gastrointestinal tract and have the ability to cause erosions and ulcers. The administration of this substance intramuscularly, and especially intravenously, is fraught with complications such as an allergic reaction. In addition, many patients have a negative attitude towards injections.

Topical application of indomethacin is characterized by a lower risk of complications or side effects. The same applies to the rectal method of administration - indomethacin suppositories.

However, it is not uncommon for a situation where the required medicine is not available at all in the pharmacy or is not available in a specific form. Is it possible to replace indomethacin with something? What analogues exist?

Side effects

When treating joint diseases with Indomethacin, the following adverse effects occur:

• nausea;
• burning inside the esophagus;
• loss of appetite;
• pain in the abdominal cavity;
• failure of the liver;
• dizziness;
• increased fatigue;
• painful sensations in the head;
• depression;
• sleep disorders;
• irritability;
• high blood pressure;
• tinnitus;
• presence of blood impurities in urine;
• bleeding;
• allergies;
• anemia;
• swelling.

With prolonged use of the drug, the formation of local negative manifestations such as burning, redness, itching and rash, redness of the skin, and the appearance of allergies is likely. When side effects appear, you should immediately contact a specialist.

Interaction

1. When this drug is combined with beta-blockers and saluretics, a decrease in their effectiveness may be observed.
2. When taken simultaneously with indirect-acting anticoagulants, their effect is significantly increased.
3. You should not prescribe drugs containing Indomethacin; together with Diflunisal, this can lead to the development of gastric bleeding.
4. When used in combination with Probenecid, it is possible to enhance the drugs of the Indomethacin group.
5. When combined with Cyclosporine, its toxicity sharply increases.
6. If you use Digoxin and Indomethacin suppositories at the same time, it is possible to increase the concentration of Digoxin in the bloodstream, this leads to an increase in its effect.

Pharmacological action of Indomethacin tablets

The mechanism of action of Indomethacin is that the drug inhibits the activity of the enzymatic group that produces prostaglandin hormones, which take an active part in the initiation and development of an inflammatory focus in the joints or body. The bone marrow's production of platelets, which contribute to painful swelling and swelling, is also reduced. At the same time, the temperature of the body area where the inflammation occurred decreases, the pain syndrome decreases, and morning stiffness and swelling go away.

After administration, according to the description, the tablets are absorbed very quickly, starting to act after 20-30 minutes, the maximum concentration of Indomethacin in the bloodstream is reached after 2 hours. A pronounced anti-inflammatory effect occurs after 5-7 days of continuous use. It is excreted by the kidneys or intestines after 6-8 hours, after intensive processing by the liver.

• Treatment of gout with medications
• Inexpensive medicines for prostatitis in men
• Neuralgia - treatment at home. Symptoms of neuralgia

Composition of the ointment

Indomethacin ointment contains a non-steroidal anti-inflammatory substance of the same name ( indomethacin ). It belongs to a large group of drugs that is used for pain relief and treatment of joint and muscle inflammation. Indomethacin is derived from an acid and has a number of side effects . Therefore, drugs with indomethacin and other non-steroidal drugs are used only when necessary, always as prescribed and taking into account contraindications.

The main effect of the ointment is to relieve inflammation and reduce pain, as well as reduce swelling, heat, remove swelling and increase range of motion. How does indomethacin treat joints?

During inflammation, so-called prostaglandins and cyclooxinases are formed in the area around the lesion. These substances are biological regulators; they expand the vascular lumens, change the activity of enzymes and the production of hormones. In case of inflammation, they cause increased temperature, swelling and pain in the area of ​​inflammation.

Note: the appearance of pain during injuries and destructive changes is a necessary reaction. It attracts a person’s attention to the disease process and signals the development of pathology. That's why you can't just numb the pain. It is necessary to treat, and pain relief will be a side effect of treatment.

The ointments are produced in tubes of 40 g, each of which contains 4 g of indomethacin. In addition to the main component, the ointment contains urea (a diuretic to reduce swelling) and formative synthetic substances (macrogols, benzoates) .

Indomethacin is a so-called prostaglandin synthesis inhibitor (stops their formation). This is due to its anti-inflammatory effect. It does not treat inflammation or counteract its cause. It relieves its symptoms.

Characteristics and description of the medication

Gel "Indomethacin" is a combination drug, a local NSAID. Used for external application. The main active component of the drug is indomethacin; additional components of the drug include: sodium benzoate, carbomer, ethanol and others.

The gel has a yellow tint and the smell of ethanol. It is placed in tubes with a capacity of thirty, fifty, ninety or one hundred and twenty grams. One gram of the drug may contain one hundred or fifty milligrams of the active substance (10% or 5%).

According to the instructions, Indomethacin gel is indicated in the following situations:

• Polyarthritis in acute and chronic form.
• Neuritis.
• Radiculitis.
• Psoriasis.
• Thrombophlebitis.
• Plexites.
• Arthritis in acute or chronic form.
• Spondylitis.
• Arthrosis.
• Bursitis and myositis.
• Swelling and inflammation after surgery.
• Rheumatism.
• Gout.
• Pain syndrome in the spine.
• Neuralgia.
• Inflammation of soft tissues due to injuries.