Diprospan: detailed instructions for use, how it works, how injections are made

special instructions

When studying the instructions for use of the medication, it is useful to pay attention to the special instructions paragraph, which contains information:

Do not inject the drug into unstable joints;
blood monitoring is carried out before and after steroid therapy;
you cannot combine Diprospan injections with the use of anesthetics in one ampoule; the mixture is prepared in a syringe;
does not affect hormonal levels;
therapy of active tuberculosis, intercurrent infections and sepsis requires combination with antibiotic therapy;
children who are in contact with patients with measles and chickenpox receive specific immunoglobulins during the treatment period.

Contraindications

According to the instructions, Diprospan injections are strictly prohibited for patients who have an individual intolerance to one of the components of the drug. The medication is prescribed with caution to patients who have been diagnosed with the following pathologies:

Diverticulitis.
Ulcerative pathology of the duodenum or stomach.
Thrombophlebitis.
Disorders of the liver, in particular cirrhosis.
Diabetes mellitus.
Chicken pox.
Mental disorders.
HIV.
Gallstone pathology.
Glaucoma.
Tuberculosis.
Hypertension.
Jade pathology.
Osteoporosis.

It is not recommended to carry out therapy with Diprospan and make intra-articular injections if processes of an infectious nature progress in the joints. It is also not recommended to use the medication if the joints are unstable or the ligaments are damaged.

Indications for the use of Diprospan tablets

The use of GCS is recommended for the following diseases:

connective tissue lesions (for example, scleroderma, dermatomyositis, periarteritis nodosa, rheumatoid arthritis);
joint diseases in acute or chronic form (including ankylosing spondylitis, Still's syndrome, polyarthritis, periarthritis, synovitis, etc.);
acute rheumatism, rheumatic carditis, minor chorea;
bronchial asthma, allergic reactions associated with damage to the respiratory organs (allergic bronchitis), lung cancer, asthma attacks;
allergic reactions to drugs or food, swelling, urticaria, serum sickness, rhinitis, drug exanthema, hay fever, forms of conjunctivitis, insect bites;
in dermatology: pemphigus, psoriasis, eczema, all types of dermatitis, pyoderma, etc.;
swelling of the brain associated with injury, disease, surgery or radiation therapy;
inflammatory process in the organs of vision;
adrenal insufficiency stage 1 or 2 (including the condition after removal of the adrenal glands), adrenal hyperplasia (including congenital);
kidney diseases of autoimmune origin (including acute glomerulonephritis);
nephrotic syndrome;
subacute thyroiditis;
in the hematopoietic organs - agranulocytosis, panmyelopathy, autoimmune hemolytic anemia, acute lymphoid and myeloid leukemia, lymphogranulomatosis, thrombocytopenic purpura, secondary thrombocytopenia in adults, erythroblastopenia (erythrocytic anemia), congenital (erythroid) hypoplastic anemia;
diseases developed against the background of tuberculosis;
berylliosis, Loeffler's syndrome (which cannot be treated with other drugs);
multiple sclerosis;
Gastrointestinal organs: ulcerative colitis, Crohn's disease, local enteritis.

Pregnancy and lactation

Treatment with Diprospan is prescribed during pregnancy if there is a special need for it (threat to the life of the mother). The doctor must weigh the expected benefits against all possible risks. Use during pregnancy is fraught with a significant decrease in immunity and an increased risk of a woman contracting serious infections. Treatment with glucocorticosteroids may slow down the growth and development of the child in the womb and cause late manifestations of adrenal cortex dysfunction.

With the systematic administration of Diprospan, there may be a need to increase the dose specifically during pregnancy. With regular or periodic use during gestation, the expectant mother should be hospitalized in advance before giving birth. The woman will be monitored for adrenal insufficiency under stress (after the onset of labor).

The newborn (if the mother was treated with Diprospan) will also require medical supervision (to monitor the functioning of the adrenal cortex). A thorough examination by an ophthalmologist is advisable for early detection of signs of cataracts (this consequence is rare, but not impossible).

In some cases, glucocorticosteroids are administered to pregnant women after 32 weeks. This reduces the risk of dyspnea in the newborn.

Betamethasone passes into breast milk. The drug may have a negative effect on the health of the newborn. If the mother needs treatment with Diprospan, breastfeeding should be stopped.

Composition and release forms

Diprospan exists as:

solution;
suspension.

Both options are designed to give injections.

The formula of the solution contains betamethasone (betamethasone 1) in the form:

disodium phosphate (2 milligrams);
dipropionas (5 milligrams).

The solution is contained in milliliter ampoules, which are packaged in boxes of one or five pieces.

Diprospan, as an injection suspension, includes Betamethasonum (active ingredient) dipropionate in the amount of 6.43 milligrams and sodium phosphate - 2.63 milligrams. These compounds contain the equivalent of 5 and 2 milligrams of the active component, respectively, as well as additional substances:

liquid for injection;
chloride, phosphoric acid salt (anhydrous disubstituted), sodium edetate;
cellulose glycolic acid;
macrogol 4000;
benzyl alcohol;
Tween (or polysorbate) 80 – solvent;
nipagin (methyl parahydroxybenzoate);
nipazole (propyl parahydroxybenzoate).

The suspension is supplied in transparent light ampoules or pre-filled syringes with a capacity of 1 ml, placed in cardboard cellular packages of one or five pieces.

Diprospan is not produced as tablets or ointment.

Use of the drug during pregnancy and breastfeeding

The effect of Diprospan and its analogues on the female body during pregnancy has not been fully studied. If the need for injections of the drug nevertheless arises, the attending physician will have to conduct a full examination and weigh all the risks so as not to harm the mother and child.

What to do if during pregnancy a woman has completed a full course of treatment with Diprospan or its substitutes? After birth, mother and baby are completely under close medical control. Observation will allow timely detection of the presence of adrenal insufficiency.

Drug analogues

There are cases when the original drug is not suitable for some reason. In such situations, it is necessary to find a high-quality analogue of Diprospan, which has similar pharmacological properties. There are several popular remedies from this group:

Flosteron injection suspension is considered an absolute analogue of the original medicine. Contains the same active ingredient and has the same therapeutic properties. It is actively used in the treatment of pathologies of joint joints and other disorders. The medicine can be administered intramuscularly, as well as inside the joint. The instructions and contraindications for use are almost the same, so the medicine is most often used as a substitute.
The drug Hydrocortisone differs in composition, but has similar pharmacological properties. It is based on the active substance of the same name, which has anti-inflammatory, analgesic and decongestant effects. The product has several dosage forms: eye ointment, powder for solution, suspension for intra-articular administration, tablets and cream for external use. The drug is not prescribed to pregnant and lactating women, children and adolescents, and patients with severe allergies to its components.
The drug Cortef has a similar therapeutic effect, but is available only in tablet form, which significantly reduces its effectiveness when it enters the digestive tract. However, it is often used for the same pathologies as Diprospan, but only at the initial stage, when there are no serious complications.
Kenalog is available in the form of tablets and suspensions for intra-articular and intramuscular administration. It is used similarly to the original product and has similar contraindications and side effects. It is prescribed in short courses and is contraindicated for daily administration, as it can cause serious complications.

Contraindications to the use of analogues

Despite the fact that there are a large number of cheap analogues of Diprospan, you cannot use them yourself.

All drugs belonging to the group of corticoids have the following contraindications:

disorders in a person’s mental state;
pathologies caused by fungus;
severe liver damage, renal dysfunction in the stage of decompensation;
HIV infection;
too high sensitivity to analogue components;
ulcerative lesions of the digestive system;
intestinal anastomosis;
low pressure;
chickenpox;
instability of the joint (when the drug is administered into its cavity);
high blood sugar;
pregnancy and breastfeeding period.

Diprospan is an effective remedy for combating many diseases, however, like any other drug, it has side effects and has certain contraindications. Before using it, you should definitely consult your doctor.

Sources:

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When is it prescribed?

Diprospan is a broad-spectrum drug and is used by doctors for various pathologies.

For diseases of muscles and soft tissues:

bursitis;
osteoporosis;
rheumatoid arthritis;
epicondylitis;
radiculitis;
lumbago;
torticollis;
fasciitis;
foot diseases

Diprospan helps against allergies, manifested by:

hay fever;
bronchial asthma;
rhinitis;
allergic bronchitis;
allergies to medications, injected serum, insect bites.

Diprospan can be prescribed for dermatological diseases:

neurodermatitis;
coin-shaped eczema;
contact or atopic dermatitis;
photodermatitis;
hives;
lichen planus;
cystic acne;
herpetic dermatitis, pemphigus.

The drug is widely used for systemic diseases:

nodular periarthritis;
dermatomyositis;
scleroderma;
lupus erythematosus.

The drug is indicated for oncological diseases of the hematopoietic organs, dysfunction of the adrenal cortex, nephritis.

What does Diprospan help with? indications and contraindications

The medication treats diseases that require the use of glucocorticosteroids. Indications can be divided into several groups, depending on the nature of the pathology.

Location	Diseases
Bones and muscles	Radiculitis; Heel spur; Torticollis; Sciatica; Arthritis of rheumatoid origin; Read also: Review of high blood pressure pills: the best drugs for the treatment of hypertension with minimal side effects Lumbago
Leather	Eczema; Psoriasis; Ringworm; Herpes; Cystic acne; Hives
Connective tissue	Polymyositis; Libman-Sachs disease; “Thick skin” – scleroderma
Blood	Leukemia; Lymphoma
Kidneys	Adrenal insufficiency

The product has proven itself in the fight against various manifestations of allergies: both seasonal and chronic. These include bronchial asthma, rhinitis and bronchitis.

In addition, Diprospan treats diseases that require therapy using glucocorticosteroids, for example:

nephritis;
hepatitis;
damage to the mucous membrane of the eye;
colitis.

Diprospan is prescribed after rhinoplasty to quickly relieve swelling.

Contraindications to the administration of Diprospan:

fungal infections of a systemic nature;
hypersensitivity to the components of the drug and any of the glucocorticosteroids;
joint instability, arthritis of infectious origin (if it is necessary to inject Diprospan solution into the joint);
children's age (under three years).

Analogues of the product and their cost

At the pharmacy you can purchase products that have similar pharmacological effects:

Betaspan. The product is available in the form of a solution. The composition contains 4 mg of betamethasone, concentrated phosphoric acid, water, sodium hydrogen phosphate dihydrate and sodium edetate. It has pronounced antirheumatic, anti-inflammatory and antiallergic effects. After application it acts quickly and powerfully. For fungal infections and allergies to components, use is prohibited. Cost - from 500 rubles.
Flosteron. The manufacturer produces the product in the form of a suspension for preparing a solution. The composition is the same as that of Diprospan. It has antitoxic, antishock and immunosuppressive effects. It is effective for allergic reactions combined with shock. Lasts for a long time. Contraindicated in case of hypersensitivity to components and systemic mycoses. Price per package - 300 rubles.
Celeston. The solution contains 5.3 mg of betamethasone sodium phosphate. Prescribed for the treatment of diseases of the digestive tract, blood, respiratory system, skin, and musculoskeletal system. Used for allergies, edema, cancer and tuberculous meningitis. The drug can be administered intravenously, intra-articularly and intramuscularly. It is contraindicated to use the solution if you are allergic to the components. Cost - from 550 rubles.
Prednisolone. The solution contains 30 mg of prednisolone sodium phosphate. Used for acute hepatitis, poisoning, shock, diseases of the respiratory tract and musculoskeletal system. Can be administered intravenously, intramuscularly. Has a quick and intense effect. Contraindicated for peptic ulcers, osteoporosis, high blood pressure, mental illness and systemic mycoses. Price per package - 100 rubles.

Pharmacological action of Diprospan

The active components in Diprospan are betamethasone sodium phosphate and betamethasone dipropionate. The excipients are sodium chloride, sodium hydrogen phosphate dihydrate, disodium edetate, benzyl alcohol, polyoxyethylene sorbitan monooleate, methyl parahydroxybenzoate, sodium carmellose, propyl parahydroxybenzoate, polyethylene glycol, water for injection, hydrochloric acid.

According to the instructions, Diprospan is a drug that stops the release of interferon gamma, interleukin 1 and interleukin 2 from macrophages and leukocytes.

Despite the affordable price, Diprospan is a very effective drug that has antiallergic, anti-inflammatory, desensitizing, antitoxic, antishock and immunosuppressive effects on the body. Diprospan inhibits the process of release of adrenocorticotropic hormone and beta-lipotropin by the pituitary gland, without reducing the level of circulating beta-endorphin. The medicine helps to blunt the secretion of thyroid-stimulating and follicle-stimulating hormones.

Entering the body after an injection, Diprospan increases the excitability of the central nervous system, increases the number of red blood cells and reduces the content of eosinophils and lymphocytes. The drug stimulates the synthesis of matrix ribonucleic acid and the formation of a complex that penetrates the cell nucleus through interaction with specific cytoplasmic receptors.

Matrix ribonucleic acid promotes the formation of proteins, including lipocortin, that mediate cellular effects. Lipocortin blunts phospholipase A2, reduces the synthesis of endoperoxides, leukotrienes, PGs and blunts the release of arachidonic acid.

The use of Diprospan helps to normalize the process of protein metabolism by reducing its amount in the blood plasma, increasing the albumin-globulin ratio and albumin synthesis in the kidneys and liver. The drug affects the processes of protein catabolism in muscle tissue.

The instructions for Diprospan indicate that the substances included in its composition take part in lipid metabolism. The drug increases the synthesis of higher fatty acids and thyroglobulin, affects the redistribution of fat deposits, and also leads to the development of hypercholesterolemia.

The use of Diprospan affects carbohydrate metabolism. The drug increases the amount of carbohydrates absorbed from the gastrointestinal tract and increases the activity of glucose-6-phosphatase, which promotes the flow of glucose from the liver into the blood.

The drug participates in water-electrolyte metabolism, retaining sodium and water in the body by stimulating the excretion of potassium. It flushes calcium from bones and increases its excretion by the kidneys.

The wide range of uses of the drug is due to the affordable price of Diprospan and its properties.

Instructions for use Diprospan method and dosage

The drug is prescribed taking into account the severity and nature of the disease.

Diprospan is administered intravenously by stream or drip. A single dose is 4-8 mg; according to indications, the dose is increased to 20 mg. The average maintenance dose is 2-4 mg. First, the infusion solution must be diluted in 0.9% sodium chloride solution or dextrose solution. The medicine should be prepared before use; the prepared solution can be stored in the refrigerator for 1 day.

The initial dose for children 1-5 years old is 2 mg, 6-12 years old – 4 mg. In order to prevent hyaline-membranous disease of newborns during premature birth, 8 mg is administered intramuscularly 48-72 hours before birth (at least 24 hours). After 24 hours, the injection is repeated.

Recommended doses for intra-articular and periarticular administration:

large joints (pelvic, knee, ankle, shoulder) – 4-8 mg,
middle joints (elbow, wrist) - 2-4 mg,
small joints (interphalangeal, sternoclavicular, metacarpophalangeal) – 1-2 mg.

When administering the drug intrawound for the treatment of skin diseases, the dose is 0.2 ml per square meter. see. The dose should not exceed 4 mg per week.

For local infiltration, the following doses are prescribed:

for the treatment of bursitis – 1-2 mg (in acute cases – up to 8 mg),
for synovial cyst and synovitis – 1-2 mg,
for the treatment of tendonitis – 2 mg,
for myositis, fibrositis, peritendinitis, periarticular inflammation, the dose is 2-4 mg.

The administration should be repeated every 7-14 days.

According to indications, subconjunctival administration is used. The dose is 2 mg.

Analogues of Diprospan in injections

Diprospan is a sterile injection suspension made from the synthetic corticosteroid betamethasone. The medicine is produced in ampoules and filled syringes. This is a dispersive liquid with a suspension. It is used for mono and complex treatment. Analogs are made on the basis of betamethasone. They have the same features as the original drug. The average price per package is 1000–1200 rubles.

Flosteron

Hormonal antirheumatic and anti-inflammatory agent. Contains 2 mg of betamethasone disodium phosphate and 5 mg of betamethasone dipropionate, in 1 ml of suspension and additional substances. Used to treat osteoarthritis, rheumatism, myositis, radiculitis, lumbago.

The ampoules are packaged in a cardboard box; 1 ml contains 7 mg of active ingredient. The required dose depends on the severity and nature of the disease and is selected individually. For systemic treatment, injections are made deep into the buttock muscle. Injection into the joint is carried out only by a doctor. For pain relief, add a 1% lidocaine solution to the syringe. The drug has the following contraindications:

spinal tuberculosis;
osteoporosis;
infectious periarthritis;
lactation period;
diabetes;
stomach ulcer;
thrombophlebitis.

The suspension is used with caution for nonspecific ulcerative colitis, liver and kidney diseases. Relative contraindications are pregnancy, immunodeficiency conditions, heart and vascular diseases, as well as children and old age

The cost of one package starts from 200 rubles.

Betaspan

This is the most popular analogue of Diprospan in ampoules. Active ingredient: betamethasone. The product is highly effective in restoring joint mobility. Eliminates inflammatory processes in the musculoskeletal system in a short time.

The ampoule contains 4 mg of active substance per 1 ml, there are 5 ampoules in a pack. It is administered intramuscularly, intravenously (in saline solution) by stream or drip. The dose, course and treatment regimen are determined by the doctor. Usually this is 8 mg of the active substance, then the amount of medication is adjusted according to the clinical result obtained. The contraindications are as follows:

hypersensitivity to incoming components;
breast-feeding;
cataract, glaucoma;
severe skin lesions.

During pregnancy, the drug is prescribed as a last resort. The cost varies depending on the volume of the active substance and the number of ampoules, the average price is 560 rubles.

Celeston

Diprospan can be replaced with Celeston in injections. 1 ml of solution contains 5.3 mg of betamethasone sodium phosphate. The medicine has a rapid absorption period and prolonged action, the effect is felt after 1–2 hours. Used as an ambulance for damage to the muscles and skeleton - post-traumatic osteoarthritis, lumbago, lumbosacral radiculitis.

The drug can be injected into the soft tissue of the affected area. In emergency cases, the medicine is administered intravenously with a solution of sodium chloride (0.9%) or glucose. After achieving the desired effect, the dose is gradually reduced. Celeston, like other analogues of Diprospan, has side effects:

disturbance of electrolyte levels;
fluid retention;
increased blood pressure;
heart failure;
muscle weakness;
osteoporosis;
joint instability.

Possible individual intolerance, ophthalmological problems, post-injection inflammation. Cost of 1 ampoule (4 mg/1 ml) from 1150 rubles.

All Diprospan substitutes have side effects. We cannot talk about a general therapeutic effect. The individual result depends on the patient’s medical history, the nature and severity of the disease

When purchasing substitutes, it is important to read the documentation so as not to buy a counterfeit

Diprospan analogs have an effective effect on all systems of the body, but if used uncontrolled, they can lead to serious complications, including death. Independent replacement of the drug is prohibited.

Pharmacological properties

Pharmacodynamics. Diprospan is a glucocorticosteroid (GCS) drug that has high glucocorticoid and low mineralocorticoid activity. The drug has anti-inflammatory, antiallergic and immunosuppressive effects, and also has a pronounced and varied effect on various types of metabolism.

Pharmacokinetics. Betamethasone sodium phosphate is highly soluble and after intramuscular administration it quickly undergoes hydrolysis and is almost immediately absorbed from the injection site, which ensures a rapid onset of therapeutic action. Almost completely eliminated within one day after administration. Betamethasone dipropionate is slowly absorbed from the depot, metabolized gradually, which determines the long-term effect of the drug, and is eliminated over more than 10 days. Betamatezone binds well to plasma proteins (62.5%). Metabolized in the liver to form predominantly inactive metabolites. It is excreted primarily by the kidneys.

How to use the drug?

Diprospan injections and its substitutes have several methods of administration: injection around the joint and inside, intramuscularly, subcutaneously, into the tissue, inside the focal area.

Intravenous injections are strictly prohibited. Also, Diprospan should not be administered between the vertebrae. A special disposable syringe is attached to the ampoules of the product.

According to the instructions for use of Disprospan, for each method of administration of the medication there is its own dosage:

intramuscularly – one to two milliliters every two to four weeks;
peri- and intra-articularly as a blocking agent:
ankle, knee, shoulder joint - one milliliter,
elbow, wrist - from half a milliliter to one,
hip joint - from one to two milliliters
sternoclavicular region, wrist joint - from a quarter of a milliliter to five;
subcutaneously - every seven days, one milliliter as an anti-inflammatory agent; in severe inflammation, the dosage can be increased to two milliliters, the injection is given inside the focal area.

The administration of Diprospan and its substitutes for allergies does not cause any pain in the patient. If the patient still experiences pain, then in this case it may be necessary to mix the medicine with an analgesic.

As soon as a lasting positive effect appears, the dosage of Diprospan (substitutes, analogues) begins to be reduced until injections are not required at all.

The course of treatment with Disprospan or its analogues takes quite a long time. Therefore, after completion, it is necessary to be observed by the attending physician for one year. Sometimes the observation period may take longer.

Administration of the drug Diprospan intramuscularly
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Contraindications and side effects

swelling;
rapid weight gain;
inflammation of the pancreas;
development of diabetes mellitus;
nervous excitability;
the occurrence of seizures several times a day;
atrophy of the skin.

When using the drug for children, developmental delay may occur.

To avoid negative consequences after use, you should pay attention to those for whom taking the drug will be contraindicated or reduced to the minimum dosage. For people with diabetes, the correct dose of medication should be selected, since a large amount of it can lead to the fact that the diabetic’s need for insulin increases significantly

The use of the drug for viral or fungal diseases will be ineffective and will only worsen the condition of the body, causing weakness. Diprospan is contraindicated for gastric ulcers, osteoporosis, arterial hypertension, and glaucoma.

Rules for the administration of Diprospan

If the drug is prescribed for intramuscular administration, one to two milliliters of the drug is usually prescribed. If it must be injected into the periarticular area, in this case zero point two milliliters are injected per square centimeter of the joint surface. If the drug must be administered inside the joint itself, then the dosage is a maximum of two milliliters per injection, the drug is administered no more than once a week.

Before administering the drug, it must be warmed to human body temperature. If the medicine is colder or hotter than the desired temperature, the patient will feel discomfort upon administration. Also, medicine heated to thirty-six degrees spreads faster throughout the body.

It is important to administer the drug correctly

When injected into the muscle, the injection must be placed in the area of the upper outer quadrant of the buttock.

Instructions for use

The instructions for use indicate that the dose of Diprospan and the method of administration depend on the clinical picture and severity of the disease.

For intramuscular administration, a dose of 1-2 ml is used. The drug is injected deep into the gluteal muscle.
When administered intradermally into the lesion, one dose should contain no more than 0.2 ml/cm2, and the total dosage per week should not exceed 1 ml.
If periarticular and intraarticular administration is necessary, the dosage can vary from 0.25 to 2 ml. Here you need to take into account the size of the joint.
If local infiltration is used, then diprospan is dosed as follows: for tenosynovitis and synovial cyst - 0.25-0.5 ml, for bursitis - from 0.25 to 1-2 ml, for fibrositis and myositis - from 0.5 to 1 ml, for tendonitis – 0.5 ml.

The injection of this drug is not painful, but in exceptional cases diprospan can be combined with an anesthetic. For pain relief, a local anesthetic is used - a one percent solution of lidocaine or procaine, which is mixed with the drug in one syringe.

Diprospan dosage regimen

The dosage and method of administration of the solution is determined individually, taking into account the type of disease and the characteristics of the patient’s body. Diprospan should be administered deeply intramuscularly, using large muscles and not touching other tissues to prevent their atrophy.

Dosage Features:

Severe conditions requiring emergency treatment and cases of arthritic form of pathology - the initial dosage is 2 ml.
Skin pathologies – 1 ml of suspension.
Diseases of the respiratory system - the drug begins to act within 2-3 hours after the IM injection.
In the treatment of bronchial asthma, hay fever, allergic bronchitis and allergic rhinitis, a positive effect is observed if the medication is administered in an amount of 1-2 ml.
When treating chronic and acute bursitis, the initial dosage of medication for intramuscular injection will be 1-2 ml. If necessary, repeated injections can be performed.

Diprospan should be administered deeply intramuscularly, using large muscles and not touching other tissues to prevent their atrophy.

Side effects of the medicine

Long-term therapy with this drug can disrupt metabolic processes in the patient's body. Therefore, with long-term use of Diprospan, the patient may notice the appearance of edema due to water retention in the body. Weight gain may also occur.
On the part of the heart, an increase in blood pressure may be observed. If the medication is taken incorrectly, there is a risk of heart failure.
Muscles lose their strength and mass, bones become more fragile, and there is a risk of osteoporosis.
From the digestive system, severe flatulence is observed, and pancreatitis may develop. The walls of the stomach and intestines are affected by ulcers and erosions.
In the presence of increased intracranial pressure, headaches and dizziness, and decreased vision may be noted. The patient may also suffer from insomnia, constant fatigue, and irritability. In severe cases, depression may develop.
Intraocular pressure increases, vision sharpness decreases. Possible development of exophthalmos. In rare cases, the patient may lose vision completely.
The patient’s individual reaction to the medicine can manifest itself in the form of allergies, from hyperemia and urticaria to anaphylactic shock.
Many patients, after introducing the drug into the body, note a feeling of a sharp rush of blood to the face.

Diprospan has serious side effects

The drug “Diprospan”: reviews, composition and properties of the drug

It's no secret that in some cases, an inflammatory disease can only be cured with the help of hormonal agents. And today the drug “Diprospan” is considered quite popular and effective. Reviews about it are mostly positive, and doctors quite often prescribe this drug to patients. So what are the properties of this medicine? Are there any contraindications? Are there any possible side effects? These questions interest many.

This medicine is available in the form of an injection solution, which is placed in transparent glass ampoules. The box contains five ampoules, each containing 1 ml of solution. The role of the main active components here is played by corticosteroids. In particular, one milliliter of solution contains 6.43 mg of betamethasone dipropinate and 2.63 mg of betamethasone sodium phosphate. Purified water, nipazole, sodium salt, carboxymethylcellulose and some other components are used as auxiliary substances in production.

This medicine is a complex of two glucocorticoid substances. It quickly blocks the inflammatory process and has a desensitizing effect. The active substances also stop the allergic reaction in the body. The drug has a mineralocorticoid effect, although it is rather weakly expressed and therefore does not have any great therapeutic significance. The uniqueness of the medicine is ensured by the content of two active components at once. Betamethasone sodium phosphate is quickly absorbed by the body almost immediately after administration and provides a quick effect. This substance is completely eliminated from the body within 24 hours. The second active component, betamethasone dipropionate, acts more slowly, creating a kind of depot in the tissues, from which it is released gradually - thus, the medicine also has a long-term effect (the period of elimination of the substance from the body is 10 days).

In fact, there are many diseases when it is advisable to take the drug "Diprospan". Reviews from specialists and patients indicate that the medicine really quickly eliminates the symptoms of inflammation and some other diseases. When is it prescribed?

To begin with, it is worth noting that the drug is widely used to treat some dermatological diseases. In particular, it is prescribed to patients suffering from contact and atopic dermatitis, coin-shaped eczema, severe photodermatitis, urticaria, herpetic dermatitis, lichen planus, cystic acne and pemphigus vulgaris. In addition, Diprospan is effective for psoriasis, as it helps relieve symptoms of exacerbations.
Since the medicine has pronounced antiallergic properties, it is used to treat diseases such as allergic bronchitis, bronchial asthma and hay fever. The drug is also effective in eliminating allergies to certain medications and insect bites.
Indications for taking the medicine are also diseases of the soft tissues and musculoskeletal system. For example, it is used to treat rheumatoid arthritis, bursitis, torticollis, osteoarthritis, fasciitis, lumbago, radiculitis, epicondylitis, etc.
The drug "Diprospan" is used for various systemic connective tissue diseases, including lupus erythematosus, periarteritis nodosa, scleroderma, dermatomyositis.
There are some other diseases that require glucocorticoids. For example, the medicine is used in modern medicine to treat adrenal insufficiency, hemoblastosis, as well as ulcerative colitis, nephritis and nephrotic syndromes. Indications for use are also considered regional ileitis, malabsorption syndrome and adrenogenital syndrome.

This solution is usually administered intramuscularly, although in some cases patients are also prescribed subcutaneous injections. When treating joint diseases, the solution can be injected directly into the joint capsule. Using the drug without permission is strictly prohibited, since only the attending physician can determine the dose and regimen - these indicators depend on many factors, including the age and condition of the patient, the stage of development of the disease, and concurrent use of other medications. As a rule, patients are administered 1–2 ml of solution every 2–4 weeks (in especially severe cases, the dose may be increased). In some cases, the administration of the drug may be accompanied by unpleasant sensations - sometimes Diprospan is administered along with an anesthetic in order to ease the pain.

Naturally, the drug has a number of contraindications. If we are talking about short-term use of the medicine, then it should not be taken in only one case - if there is hypersensitivity to any of the components. The medicine "Diprospan" for joint diseases is usually injected directly into the joint cavity. In such cases, contraindications include joint instability, the presence of periarticular infection, bleeding disorders and previous arthroplasty. The solution should not be used for subcutaneous injections to patients suffering from a variety of infectious skin diseases, acne and dermatitis. In addition, contraindications include renal failure, diverticulitis, peptic ulcers, osteoporosis, tuberculosis, thrombophlebitis, ulcers, nephritis, and liver disease. The medicine is not used during the vaccination period, as well as for chickenpox. The drug is not used to treat pregnant women and nursing mothers.

Short-term use of the drug rarely leads to any side effects other than an allergic reaction. However, with long-term use, more serious consequences of taking Diprospan are possible. Reviews from doctors and the results of pharmacological studies indicate that some patients experience disorders of the digestive system, including flatulence, pancreatitis, ulcers, and polyphagia. Sometimes there is increased excitability, neurosis, depression, sleep disturbances, swelling, headaches, convulsions, increased intracranial pressure, arterial hypertension. Hormonal drugs can cause metabolic disorders, such as osteoporosis, complications of infectious diseases, growth retardation in children, menstrual irregularities, secondary renal failure, and weight gain.

Characteristics of the medicine

Diprospan belongs to the group of corticosteroids used systemically. The medicine is produced as a suspension for the preparation of an injection solution. It has a pronounced anti-inflammatory effect, therefore it is used for inflammatory processes of various etiologies.

The active ingredient of Diprospan is betamethasone, consisting of two fractions - disodium phosphate 2.63 mg and dipropionate 6.43 mg. The first substance ensures the rapid action of the drug, and the second its prolonged therapeutic effect.

Diprospan blocks the production of prostaglandins, the main provocateurs of inflammation. The drug retains sodium in the blood, but removes hydrogen, ammonium and potassium. But this action is weakly expressed.

In addition, he:

has an anti-shock effect;
activates the body's immune response;
relieves allergy attacks.

The drug is released in ampoules of 1 ml. It is prescribed intramuscularly, injections are given inside the joints, and injections are also made into the affected areas. The advantages of Diprospan over other corticosteroids are the speed of action, long-term preservation of the therapeutic effect, and fewer side effects.

The benefits of taking the medicine are noted after 2-3 hours and last for one month. In addition, to achieve clinical recovery, the patient needs rare injections of the drug, as well as a minimum therapeutic dose.

Pharmacological action and composition of the drug

Betamethasone is the main active component of this drug.

The drug is available in the form of ampoules of one milliliter. The consistency of the drug should be slightly viscous.

The main component of Diprospan is betamethasone

Compound.

Betamethasone disodium phosphate – 2 milligrams.
Betamethasone dipropionate – 5 milligrams.

The drug has high glococorticosteroid activity. It also contains slight corticoid activity. This drug has a pronounced anti-inflammatory effect, which is necessary in the treatment of osteochondrosis. The composition of the drug allows it to effectively influence areas of inflammation and suppress the development of the inflammatory process in them.

In addition, Diprospan also has an immunomodulatory and anti-shock effect. The effect of the drug occurs within ten to twenty minutes after its administration, which is why Diprospan is widely used to relieve acute pain, as well as as an emergency anti-shock drug. After administration of the suspension, the drug continues to act in the body for another three days.

Analogs

The solution has many analogues:

Cortef;
Polkotoron;
Kenalog;
Medrol;
Flosteron.

The latter is a complete analogue of Diprospan. If the latter is not available, you can purchase Flosteron at the pharmacy. However, it is still worth consulting a doctor.

An almost complete analogue of the product is Kenalog, but Diprospan is more effective and its cost is higher.

There are also analogues of the medication in the form of ointments. These include:

Akriderm;
Beloderm and Beloderm Express;
Celestoderm.

Only a specialist can judge the possibility of using drugs like Diprospan.

Many patients are wary of hormone therapy because they are afraid that they may affect the body and, having cured one disease, will cause another. Indeed, this kind of treatment is carried out only under the supervision of a doctor, then the result will not be long in coming.

The drug Diprospan, which belongs to the group of glucocorticosteroids, has long established itself as an effective remedy at an affordable price. It affects the body, helping to cope with many pathologies. Reviews about it are mostly positive. Despite all the advantages, it should be remembered that self-prescription and self-medication are dangerous. Before using any medicine, even the best one, you should definitely consult a doctor.

Price and analogues of Diprospan

One ampoule of the product costs around 200 rubles, and a package with five ampoules costs an average of 800 rubles. If we talk about cheaper analogues of the drug, then they are all produced in Ukraine. Let's look at some of them:

"Betameson". This is a popular analogue of the drug "Diprospan". Also included in the group of synthetic glucocorticosteroids. It is produced on the basis of betamethasone dipropionate, which allows the drug to quickly relieve inflammation and allergic manifestations. It is available in the form of ointments, ampoules and tablets. Often prescribed for stomach ulcers, tuberculosis, osteoporosis, some sexually transmitted diseases and glaucoma.
"Prednisolone" is an analogue of "Diprospan" in injections. It is also a hormonal drug, cheaper. Quite common in the treatment of arthrosis, psoriasis, arthritis, allergies and various dermatological pathologies. The drug should not be used against the background of a fungal infection. It is quite difficult to choose which is better - Prednisolone or Diprospan.
"Mesoderm". A drug based on betamethasone. This analogue of Diprospan is used to treat skin and joint pathologies, as well as various types of allergies. Do not use for acne, tuberculosis, syphilis and fungal infectious diseases.
"Betaspan". Used for systemic use. Produced in ampoules. People often don’t know what to choose: “Diprospan” or “Betaspan”. The latter is prescribed for diseases of allergic, respiratory, dermatological, rheumatological, hematological and gastrointestinal origin. The drug should not be administered against the background of progressive mycosis, as well as in case of hypersensitivity to the components of the solution.

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Let's consider reviews about Diprospan and analogues.

Indications

Before prescribing glucocorticosteroids to a patient, the doctor must fully study his medical history, symptoms, and pathologies. This is necessary because in many cases this group of drugs can be prescribed in addition to existing therapy, since treatment with glucocorticosteroids alone may be ineffective.

"Diprospan" refers to glucocorticosteroids

Diseases for which glucocorticosteroids are prescribed:

osteochondrosis of the spine, regardless of its location;
rheumatoid arthritis;
inflammatory processes of soft tissues and ligaments.

There are also a number of diseases for which glucocorticosteroids are used as additional therapy, including:

allergies;
skin lesions;
renal failure;
connective tissue damage.

“Diprospan” is especially effective for pathologies of the locomotor system, including osteochondrosis

What are the contraindications?

The use of Diprospan and its analogues may not always bring the desired effect. There are a number of diseases for which the use of this medication is contraindicated.

What's on this list?

Fungal infectious diseases;
acute stages of liver disease and renal failure;
stomach and duodenal ulcers;
intestinal obstruction;
diseases of the musculoskeletal system, including infectious arthritis, poor joint stability;
hypotension;
human immunodeficiency virus (HIV);
chicken pox;
disease of the nervous system.

Also, Diprospan and its substitutes should not be used if there is a risk of an allergic reaction to any component, as well as if you are intolerant to drugs from the glucocorticosteroid group.

Diprospan indications for use

special instructions

Glucocorticoids increase tolerance to ethyl alcohol, reducing its toxic effect on the body. At the same time, the concentration of alcohol in the blood remains the same. This allows the use of these hormonal drugs in the treatment of ethyl alcohol poisoning.

Diprospan can be mixed with solutions of local anesthetics in equal volumes. It is unacceptable to use the medication in the treatment of hyaline membrane disease in newborns. The drug should not be injected into the intervertebral spaces, into infected areas and unstable joints. Before starting treatment, it is necessary to conduct an examination: a general blood test, blood glucose levels, electrolytes. For concomitant tuberculosis, sepsis, and intercurrent infections, antibiotics are administered simultaneously.

Ophthalmology

Diprospan has found its application in the treatment of eye diseases. It is successfully used in the postoperative period for eye surgeries, in the treatment of endocrine ophthalmopathy and cholazion. The drug is quickly absorbed by tissues and has a prolonged effect.

It does not cause complications because it does not crystallize in tissues. The long-term effect of the drug provides a long-lasting therapeutic effect and reduces the need for repeated use of the drug. In ophthalmic practice, Diprospan is administered parabulbarly or used in press therapy.

It is possible to administer the medicine directly into the cholazion. The drug accumulates around the orbit of the eye, so it needs to be injected half as much as similar corticosteroids (for example, Dexamethasone). With retrobulbar administration, the interval between injections is 7-12 days. The course of treatment involves 4-5 injections over two months. If Diprospan does not help, then an analogue that has a similar effect in a higher dosage (Dexamethasone) is prescribed.

The use of the medicine is possible only after prescription by a doctor, since it causes:

persistent hypertension;
worsening of diabetes mellitus;
exacerbation of chronic diseases;
steroid cataract.

Diprospan is prescribed with caution to children, since the drug causes a delay in puberty, inhibits the process of formation of the skeletal system and the development of the child as a whole. Long-term use of high doses of the drug, as well as combining it with certain medications, causes side effects

Thus, its simultaneous use with azathioprine promotes the development of myopia or cataracts. In patients suffering from glaucoma, the use of Diprospan together with antidepressant medications increases ocular hypertension. Antiepileptic drugs used together with Diprospan reduce its effect. Taking other hormonal drugs together with Diprospan increases the risk of side effects.

Long-term use of high doses of the drug, as well as combining it with certain medications, causes side effects. Thus, its simultaneous use with azathioprine promotes the development of myopia or cataracts. In patients suffering from glaucoma, the use of Diprospan together with antidepressant medications increases ocular hypertension. Antiepileptic drugs used together with Diprospan reduce its effect. Taking other hormonal drugs together with Diprospan increases the risk of side effects.

Side effects

A single use or a short course of therapy does not cause significant side effects.

The following side effects are possible when taking the drug:

hypernatremia, increased excretion of calcium and potassium from the body, fluid retention in tissues, weight gain;
increased blood pressure, chronic heart failure;
steroid myopathy, muscle weakness, tendon ruptures, osteoporosis, tubular bone fractures, aseptic femoral and necrosis of the humeral head;
hiccups, pancreatitis, flatulence, erosive and ulcerative lesions of the gastrointestinal tract;
increased sweating, dermatitis, steroid acne, atrophy and thinning of the skin, impaired wound healing;
convulsions, headache, increased intracranial pressure, dizziness, increased irritability, mood changes, depression and insomnia;
secondary adrenal insufficiency, steroid diabetes mellitus, menstrual irregularities, delayed growth and sexual development in pediatric patients;
glaucoma, cataracts, increased intraocular pressure; arterial hypotension, shock, angioedema, anaphylactic reactions;
subcutaneous and cutaneous atrophy;
aseptic abscesses.

Is the drug related to hormones?

Is Diprospan a hormonal drug? In humans, the adrenal cortex produces its own glucocorticosteroid hormones. They ensure the proper functioning of tissues and body systems. Glucocorticosteroid hormones determine the normal growth of the child. These substances are very important.

Diprospan is a medicinal product related to hormonal substances. It is created artificially. Hormonal medications are excellent in treating autoimmune processes, allergic reactions, and severe inflammation. Diprospan contains betamethasone, a hormonal substance.

Is the Diprospan injection hormonal or not? Diprospan has its own side reactions characteristic of hormonal drugs from the GCS group. Injections can cause tissue atrophy, facial skin hyperemia, and tissue abscess formation.

Common adverse events include:

osteoporosis;
steroid myopathy;
bone fractures;
dysfunction of the adrenal glands;
steroid stretch marks;
mood swings;
sleep disturbance;
Itsenko-Cushing syndrome;
steroid-induced diabetes mellitus;
delay in sexual development.

Other reactions to taking the drug are also possible. After completing therapy with the hormonal drug Diprospan, its effects gradually fade away.

Interaction with other drugs

This drug interacts with some other drugs. In particular, it weakens the effect of taking diuretics, insulin, anticoagulants and vaccines. It is worth considering that when taking Diprospan and non-steroidal anti-inflammatory drugs simultaneously, the risk of ulcerative lesions and bleeding in the gastrointestinal tract increases. On the other hand, the drug enhances the effects of hormonal contraceptives.

Drug interactions

When using Diprospan simultaneously with other medications, the following are observed:

acceleration of the metabolism of betamethasone with phenytoin, rifampin, ephedrine, phenobarbital with a decrease in the effectiveness of therapy;
changes in blood clotting with indirect anticoagulants are likely; dose adjustment is necessary;
the likelihood of hypokalemia increases with potassium-sparing diuretics;
increased potassium excretion provoked by amphotericin B;
decrease in the blood plasma concentration of salicylates with GCS;
the likelihood of digitalis intoxication (due to hypokalemia) and arrhythmia with cardiac glycosides increases;
it is possible to adjust the dose of drugs with estrogens, due to the danger of their overdose;
it is possible to increase the frequency of intensity or occurrence of erosive and ulcerative diseases of the gastrointestinal tract with ethanol-containing drugs, ethanol, NSAIDs;
it is possible to slow down the absorption of somatotropin when administered simultaneously with GCS;
The influence of GCS on the nitrogen blue tetrazole test directly on bacterial infection is noted and can provoke a false negative result.

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Analogues and substitutes of Betaspan

Analogues of the drug Betaspan based on the main active ingredient are:

Flosteron;
Depos;
Loracort;
Diprospan.

The above drugs have the same ATC codes and chemical structure.
The difference lies in the doses of the active ingredients of the drugs and the place of production. Treatment of endocrine skin diseases and pathologies of the musculoskeletal system can be carried out with Betaspan or Diprospan.

The drugs are completely interchangeable, differ slightly in price and list of side effects. The decision about whether to prescribe Diprospan or Betaspan to a patient can only be made by the attending physician.

Substitutes for Betaspan according to indications and method of use - Prednisolone, Dexamethasone, Medrol, Cortisone, Dexazone, Metypred.

Medicines for gout: tablets, ointments, injections, full list of drugs

Gout is a complex joint disease that must be treated with medications. The joint is affected due to excessive amounts of uric acid and its salts. Medicine for gout is selected based on examination of the patient, determining the causes of the pathology. Treatment must be carried out immediately.

Causes and symptoms of pathology

So, gout is most often localized on the big toes. The cause of the development of the disease may be too much physical activity, poor nutrition, or metabolic disorders in the body.

Gout is an insidious disease. It may not appear for a long time. During an exacerbation, it has the following symptoms: swelling of the affected area, increased local temperature, severe joint pain, which appears most often at night. The joint becomes very sensitive to any touch.

Features of treatment of gout during exacerbation

So, it is advisable to carry out treatment inpatiently. At this stage of treatment, it is important to eliminate severe pain, eliminate or reduce the intensity of the inflammation process in the joints, and restore normal joint mobility. During the period of exacerbation, the attack is stopped with the help of several groups of drugs.

Nonsteroidal anti-inflammatory drugs

Butadion. This is an anti-inflammatory ointment that can relieve pain and fever. In addition, this drug is considered a good antirheumatic agent. Apply the ointment in a thin layer around the affected area. There is no need to rub it in.

Indomethacin. This tablet drug is considered one of the most effective non-steroidal anti-inflammatory drugs. It is prescribed for the treatment of gout in the legs in most cases. The main advantage of the medicine is the ability to quickly relieve pain during exacerbation. You need to take 0.05 g tablets three times a day. Another form of Indomethacin is an ointment.

Ibuprofen. This medicine is also used in tablet form. Most often, Ibuprofen is used during the period when the exacerbation attack has reached its peak and the symptoms are most pronounced. The daily dose can range from 1200 to 2400 mg.

Digestion and Absorption

When ingested, the active component is divided into 2 substances - sodium phosphate and betamethasone dipropionate. The first is quickly absorbed and provides a therapeutic effect, the second creates a certain reserve and is gradually released, providing a therapeutic effect. Sodium phosphate is excreted within 24 hours.

The maximum concentration of the drug in the blood is achieved 2 hours after administration. Dipropionate is metabolized rather slowly, and its supply is maintained for 8-10 days without repeated administration.

The period of absorption and excretion largely depends on the condition of the patient and the individual characteristics of his body. As a rule, in patients with disorders of the gastrointestinal tract or urinary system, this period increases slightly. But scientists have proven that prolonging it does not affect the therapeutic effect. The main amount of the active substance is excreted through the kidneys in a processed form, some unchanged.

Diprospan injections for joints

Diprospan is a glucocorticoid drug for parenteral administration, which is a unique drug that combines a long-acting form and a fast-acting substance. Thus, Diprospan injections not only contribute to the rapid elimination of pathological symptoms, but also provide a long-lasting therapeutic effect.

What is Diprospan

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Indications for use

According to the instructions for use, Diprospan injections can be used in the following cases:

inflammatory diseases of the structures of the musculoskeletal system (myositis, tenosynovitis, synovitis, bursitis);
pain syndrome due to arthrosis of the knee joint and other joints of the body (blockade of the knee joint);
Diprospan for rheumatoid arthritis can effectively eliminate pain;
injections help eliminate joint pain due to gout and psoriasis;
with osteochondrosis of the spine with persistent pain syndrome;
conservative treatment of hygroma of any location;
humeroscapular periarthritis (blockade of the shoulder joint);
pain in the lumbar region, thoracic spine and neck;
pain syndrome after traumatic injuries;
with osteochondrosis of any segment of the spinal column and its consequences (spinal hernia);
allergic reactions (insect bites, hay fever, hay fever, allergic rhinitis, urticaria, Quincke's edema);
shock states of various origins;
attack of bronchial asthma;
various skin diseases;
systemic connective tissue diseases;
treatment of leukemia;
adrenal insufficiency;
liver diseases and liver failure.

Directions for use and doses

Diprospan can be used for:

intramuscular injection;
joint injections;
injection into the soft tissue around the joint (blockade);
intravenous administration of synovial bursae;
intradermal use.

The medicine is not intended for intravenous and subcutaneous administration. The dosage regimen and duration of therapy are determined in each case individually, depending on the disease and its severity.

For systemic therapy (intramuscular administration), Diprospan is used in an initial dose of 1-2 ml. Further treatment is carried out as needed, depending on the patient's condition.

But most often the drug is administered topically. In such cases, it is often used together with local anesthetics (lidocaine, procaine). Diprospan is administered into the joint in a dose of 0.5-2 ml. Approximate dose calculation, depending on the size of the joint:

large – 1-2 ml;
medium – 0.5-1 ml;
small – 0.25-0.5 ml.

As a rule, the course of treatment is 1-5 injections with an interval of 1 week. After achieving the desired result, the dose of the drug should be gradually reduced to the minimum effective. And only after that you can try to cancel it completely. If pathological symptoms return again, then the dose of Diprospan is increased.

Side effects and contraindications

Diprospan, like any other glucocorticoid, has many side effects and contraindications for use.

Main side effects:

disturbance of metabolic processes in the body (increased sodium concentration, decreased potassium amount, obesity, development of alkalosis and lipomatosis);
provoking the development of heart failure and increased blood pressure;
muscle weakness and loss of mass, development of osteoporosis, provocation of bone fractures and tendon ruptures;
development of gastritis and gastrointestinal ulcers, gastrointestinal bleeding;
activation of latent infection, development of candidiasis, suppression of immunity;
development of steroid acne, stretch marks on the skin;
increased pressure inside the skull, convulsions, headache, dizziness, insomnia;
menstrual irregularities in women, secondary adrenal insufficiency, steroid diabetes mellitus, Itsenko-Cushing syndrome;
provocation of cataracts, glaucoma, exophthalmos;
allergic reactions, up to anaphylactic shock.

The frequency of side effects, as well as the degree of their severity, depends on the method of drug administration and duration. As a rule, all side effects are well eliminated by reducing the dose of the drug.

Administration of Diprospan is contraindicated:

with systemic mycotic lesions;
for intravenous and subcutaneous use;
for injections into the joint for infectious arthritis, instability of the joint associated with pathology of the ligamentous apparatus;
with a skin infection at the injection site;
in children under 3 years of age;
if you are hypersensitive to this drug or other glucocorticoids;
if there are systemic parasitic and infectious diseases;
in a state of immunodeficiency;
in the period after vaccination;
for gastrointestinal tract diseases;
for arterial hypertension, severe heart failure;
for diabetes, thyrotoxicosis, Itsenko-Cushing's disease;
with kidney failure;
for osteoporosis.

Use during pregnancy and lactation

To date, there is no data on possible risks to the fetus when the mother uses the drug Diprospan, since no studies have been conducted. Taking this into account, such treatment is contraindicated and can be used in exceptional cases when the benefit to the mother outweighs the risk to her unborn child.

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If there is a need to use Diprospan injections in nursing mothers, then switching to artificial feeding should be considered, since the penetration of the drug into breast milk and its negative effect on the baby has not been studied.

Overdose

As a rule, exceeding the dose of the drug does not lead to life-threatening conditions. If very high doses are used for diabetes, glaucoma, or acute peptic ulcers, conditions may develop that require emergency care.

Terms of sale

Diprospan belongs to the group of prescription drugs and is dispensed from the pharmacy strictly according to a doctor’s prescription.

Price and analogues

The average price for Diprospan injections for one ampoule ranges from 325-400 rubles, for a package of 5 ampoules - 1000-1200 rubles.

Analogues of Diprospan:

Betaspan Depot,
Depos,
Flosteron,
Betamethasone-Norton,
Betaspan,
Soderm,
Celeston.

Reviews of Diprospan injections

Lyudmila, 25 years old: “My dad has been suffering from rheumatoid arthritis for 25 years. Despite basic therapy, he suffers greatly from constant pain in his ankle and elbow joints. The attending physician prescribed Diprospan injections into his joints. One injection was given into each painful joint once every 3 weeks. My health has improved significantly, the pain has almost gone away.”

Nina Ivanovna, 62 years old: “I have been suffering from arthrosis of the knee joints for 10 years. Problems began with the onset of menopause. I tried various painkillers and anti-inflammatory drugs, but the pain still did not go away. I had to start walking with a cane. A friend advised me to try Diprospan intra-articular injections. I noticed relief after just 1 injection; after the 3rd, the pain completely disappeared. At this point I stopped treatment, but, unfortunately, the pain returned again after 2 months. Conclusion: the medicine is excellent, but the effect is short-term.”

Oleg, 40 years old: “Due to my professional activities, I have been suffering from osteochondrosis of the lumbar spine since I was young. The pain is constant, analgesics and NSAIDs eliminate the pain syndrome for only a few hours. The doctor advised me to do a spinal block with anesthetics and Diprospan. Immediately after the first injection, the pain decreased significantly and I began to move more freely. The full course of treatment consisted of 4 injections. It's been 2 months now and the pain hasn't returned. True, I started doing physical therapy because injections are too expensive.”

In conclusion, it is worth noting that Diprospan is an excellent assistant in the fight against acute pain and inflammation, especially in the case of pathology of the musculoskeletal system. But do not forget that this is only a symptomatic remedy. Although it relieves acute symptoms, it is often unable to eliminate the true cause of pain. Therefore, such therapy should be prescribed only in emergency cases and never replace physical therapy and other basic therapeutic measures.

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Indications for therapy

Since the drug has anti-shock properties, it is often used as an emergency aid for shocks of various etiologies. This can be toxic, burn, cardiogenic or traumatic shock. There are other cases when the medicine is used to relieve acute symptoms:

Acute allergic reactions with the threat of transition to anaphylactic shock.
Deterioration of the patient's condition during blood transfusion.
Severe form of bronchial asthma of various etiologies with frequent attacks of suffocation.
Poisoning with toxic substances of varying severity.
Severe rheumatoid arthritis with severe pain.
Severe bursitis with suppuration of the intraarticular bursa.
Advanced stage polyarthritis.
Chronic deforming osteoarthritis.
Spondylitis, intervertebral hernia.
Allergic reaction to the introduction of foreign serum.
Severe irritation from insect bites.
Allergic reaction to drugs, food, pollen with the development of chronic dermatitis and rhinitis.
Systemic pathologies, for example, lupus erythematosus.
Dermatological diseases: psoriasis, eczema, lichen planus, alopecia of various etiologies and severity.
Advanced stage adrenal insufficiency.
Ulcerative colitis of nonspecific type in the acute stage.

An absolute contraindication for the use of the drug is hypersensitivity to its components. But there are many pathologies that can worsen when using the drug:

Chronic form of arterial hypertension at an advanced stage.
Pathologies of infectious and viral nature in the acute stage.
Severe form of type 1 diabetes mellitus.
Fungal pathologies of mucous membranes and skin.
Ulcerative lesion of the gastric mucosa with the threat of perforation of the organ wall.
Acute stage of tuberculosis with pronounced clinical manifestations.
Advanced osteoporosis.
Glaucoma of various forms.
The period of bearing a baby and breastfeeding.
Children and teenagers up to 18 years of age.
Thrombophlebitis in the acute stage with pain.
Mental disorders of a chronic form with regular relapses.

You should not use the medicine simultaneously with vaccination drugs, since the body's reaction may be unpredictable. Since the medicine is administered not only intramuscularly, but also into the joint cavity, there are contraindications for the second use.

You should not inject the drug into a joint in case of acute osteomyelitis, arthritis of infectious etiology, instability of the joint joint, if the cause of severe pain in the joint is unclear, or severe hemarthrosis. It is strictly contraindicated to use the product in conjunction with anticoagulants, as it reduces their effectiveness.

It is noted that when drinking alcohol during treatment with the drug, the body’s sensitivity to its negative effects decreases. At the same time, the concentration of harmful compounds in the blood does not decrease. A person will not feel a boundary that cannot be crossed, which will lead to various violations. This especially applies to people who suffer from chronic alcoholism.

For various pathologies, the medicine is administered intramuscularly as deep as possible into the gluteal muscle. Incorrect injection technique often leads to complications such as compaction at the injection site or the appearance of an abscess. To avoid this, it is recommended not to use the medicine yourself at home.

In case of severe damage to the visual apparatus, it is possible to administer the medicine through the lower eyelid to achieve the maximum therapeutic effect. However, this method of administration is used extremely rarely due to the threat of unpleasant complications. The course of therapy for intramuscular administration does not exceed 5 injections. In rare cases, it is extended, but only under strict indications.

The procedure is not carried out every day. Typically, the interval between them ranges from 1 to 3 days, depending on the severity of the violation. If the medicine is injected into the joint cavity, the procedure is performed only by a doctor in a hospital setting. After this, the patient is recommended to spend a day under observation.

If paired joints are affected, the medicine is administered to them alternately with an interval of 7-14 days. The medicine is administered into one joint no more than once every 3 months. More frequent use is permitted in cases of extreme necessity and the impossibility of finding an alternative. The joint area at the supposed puncture points should be treated with medical alcohol. After this, the doctor begins to inject, trying to avoid nerve endings. To do this, he first probes the articular joint.

If the hip joint is affected, the entire volume of the medicine is injected into one point, since the place is dangerous and there is a risk of hitting the nerve. If the knee joint hurts, the injection is given on both sides at the points of greatest pain. The specialist injects half of the volume into one point, and the other half into another.

After removing the needle, the puncture site is again treated with alcohol and covered with a special adhesive plaster. As a rule, severe bleeding does not develop in this area, so a large amount of dressing material is not required.

This procedure is called a blockade, and after it is carried out it is not recommended to load the joint for at least 1 hour. The best option would be a horizontal position. Observation over the next 24 hours is necessary to exclude possible complications. It is better to ask your doctor about how many injections you will need.

Diprospan is a drug from the glucocorticosteroid group. It is characterized by increased glucocorticoid activity and insignificant mineralocorticoid activity. The drug has an immunosuppressive and antiallergic effect, has a pronounced and varied effect on all types of metabolic processes in the human body.

The main active ingredient of Diprospan is betamethasone sodium phosphate. It is highly soluble in liquid and, after intramuscular administration, is quickly absorbed from the injection site and undergoes hydrolysis.

This ensures the earliest possible start of treatment. Almost all of the drug is excreted by the kidneys within 24 hours after administration.

Diprospan is presented in the form of a suspension (for injection into the joint) and a solution for injection. It is indicated for the treatment of adults suffering from diseases in which glucocorticosteroid therapy makes it possible to achieve the desired clinical effect.

It should be borne in mind that a Diprospan injection in some cases will be an additional treatment that cannot replace classical therapy. So - diprospan instructions for use, what do you need to know?

So, the drug is recommended for ailments:

musculoskeletal system and soft tissue pathologies (bursitis, rheumatoid arthritis, torticollis, epicondylitis, osteoarthritis, fasciitis, ganglion cyst, coccydynia);
allergic (bronchial asthma, allergic bronchitis, seasonal rhinitis, drug allergies, hay fever, serum sickness, reactions to various insect bites);
dermatological (atopic dermatitis, neurodermatitis, coin-shaped eczema, contact dermatitis, alopecia areata, urticaria, severe photodermatitis, lichen planus, keloid scars, cystic acne, psoriasis, pemphigus vulgaris);
systemic connective tissue diseases (lupus erythematosus, periarteritis nodosa, scleroderma, dermatomyositis);
primary and secondary adrenal insufficiency (due to the use of mineralocorticoids);
hemoblastoses (acute leukemia in children, palliative treatment of leukemia and lymphomas in adult patients).

Also, indications for use are other problems and pathological conditions that require treatment with glucocorticosteroids (regional ileitis, adrenogenital syndrome and pathological disorders in the blood).

The medicine is necessary for intramuscular, interstitial, intraarticular, periarticular, intralesional and intradermal injections. Due to the small size of betamethasone crystals, it is possible to use a small-diameter needle for insertion into the lesion and subcutaneously (which cannot be achieved using another drug).

Diprospan and its analogues are administered using a disposable syringe, which should be shaken before use. It is strictly forbidden to inject Diprospan subcutaneously and intravenously! When using the medicine, absolute compliance with the rules of septic tanks is provided.

The method of dosing and administration in each specific case will be selected individually and depends on the indication, the patient’s response and the severity of his disease.

If the treatment is systemic, then the initial dosage of the drug will be 1-2 ml. Repeat the administration if necessary and depending on the current condition of the patient. Intramuscular injection should be done deeply, choosing large muscles for this. To prevent atrophy, it is important to avoid contact with other tissues.

The instructions for use state that the volume of the administered drug will vary depending on the pathology:

in conditions that require emergency measures, the initial dose will be 2 ml;
for dermatological problems, 1 ml is prescribed;
for respiratory diseases, 1-2 ml should be used (hay fever, bronchial asthma, allergic rhinitis and bronchitis). The start of work occurs within a couple of hours after intramuscular injection of the suspension;
for chronic and acute bursitis, the initial volume will be 1-2 ml of suspension. If necessary, several additional injections are given.

If the expected clinical response does not occur after a certain period of time, the injection should be discontinued and treatment reconsidered.

A local injection only in rare situations requires an additional local anesthetic. To do this, it is better to use a 1% or 2% solution of lidocaine or procaine hydrochloride.

First, the drug Diprospan is drawn into it, and then the required volume of local anesthetic is taken from the ampoule and the syringe is shaken.

Diprospan: price

You can buy Diprospan in Moscow at an average price of 211.15 rubles for 1 ampoule of injection solution and 213.04 rubles for 1 ampoule of injection suspension.

Price in Ukraine: Diprospan can be purchased at an average price of 68 - 494 hryvnia for 5 ampoules.

It is possible to buy Diprospan in Minsk at a price of 300,000 – 333,400 Belarusian rubles.

The price of 1 ampoule of Diprospan is about 220 rubles. You can buy the drug in Moscow for about 230 rubles.

The price of Diprospan injections in Ukraine is 1100-1600 UAH for 5 ampoules of 1 ml.

How much does an allergy shot cost, for example, in Kharkov? Approximately 250 UAH. In Odessa - 290 UAH.

Tablets of this drug are not sold.

The price of Diprospan in Russian pharmacies is about 200 rubles.

Which is better – Kenalog or Diprospan

Kenalog and Diprospan have similar properties, but there is a difference between them. Thus, when treating joint diseases, doctors often prescribe Diprospan. The fact is that it is distinguished by the small size of its crystals. Research shows that they are three times less than Kenalog. These sizes make it possible to inject Diprospan directly into the joints and periarticular capsules.

This gives a pronounced therapeutic effect and helps prevent side effects, since injections of the drug into the joints in this case do not cause crystalline synovitis, as happens when using other drugs from this group, and also do not lead to atrophy of the skin and muscles.

It has been proven that Diprospan has the most powerful anti-inflammatory effect compared to all drugs in its group, including Kenalog.

Unlike Kenalog, Diprospan gives fewer side effects, does not cause retention of potassium and sodium salts in the body, thus there are no prerequisites for the appearance of swelling.

Careful reception

The drug "Diprospan" and analogues are prescribed with caution and under strict medical supervision in the following situations:

Osteoporosis.
HIV and AIDS.
Chicken pox, measles.
Tuberculosis in latent or active form.
Purulent lesions, including abscess.
Increased fat content in the blood.
Liver failure, cirrhosis.
Kidney failure or other pathological processes in these organs.
Obesity that has reached the third or fourth stage.
The period of bearing a child and breastfeeding.
Angle-closure glaucoma.
Recent surgery in the intestinal area.
Two months after vaccination.
Lymphadenitis resulting from BCG vaccination.
Recent pathologies of fungal, viral or parasitic origin.
Endocrine diseases such as hypothyroidism, diabetes mellitus, Itsenko-Cushing syndrome, thyrotoxicosis, etc.
Administration of the drug intramuscularly for thrombocytopenic purpura.
Pathologies of the digestive system that occur in a chronic form during the period of exacerbation, such as gastritis, peptic ulcer and ulcerative colitis.
Recent myocardial infarction, since the drug increases the risk of proliferation of a necrotic lesion, as well as rupture of the heart muscle.
Acute mental illnesses, such as schizophrenia, manic psychosis and others.

It’s easy to find analogues cheaper than Diprospan.

Overdose

If the dosage prescribed by the doctor is exceeded, the following symptoms occur:

Sleep disturbance.
Nausea.
A state of euphoria.
Nervous excitement.
Depressive state.

In addition, administration of large doses can cause increased pressure in the arteries, osteoporosis and fluid retention in the body.

If signs of overdose appear, the administration of the drug is canceled, the balance of electrolytes in the body is adjusted, antacids, lithium-containing drugs and phenothiazines are taken.

Reviews

Victoria, 32 years old, Moscow: “I don’t have the best memories associated with Diprospan. This drug was injected into my grandmother when she was dying of bone cancer. The product really helped - it reduced pain, enhanced the effect of analgesics, but the relief was short-lived. I had to inject more and more often, and after about 10 injections my kidneys stopped working. In general, for allergic snot, this is too much.”

Igor, 54 years old, Yekaterinburg: “I buy Diprospan and inject myself. A doctor once prescribed it to me for psoriasis. The drug helps, but not for long. The plaques still get inflamed.”

Nelya, 59 years old, Sochi: “I was injected with Diprospan for a heel spur. Heel pain appears every spring and is very bothersome. The drug works quickly and reliably. 2 injections at intervals of a week and the pain disappears. The product does not eliminate the problem, but it relieves the symptoms perfectly.”

Anastasia, 33 years old, Nalchik: “I bought Diprospan only once, when I was bitten by a bee and my larynx began to swell. I was terribly scared. I was afraid that the remedy would not help. 1 ampoule was enough, the swelling quickly began to subside. The second one is there “just in case.” I hope it doesn't come."

Compound

On the pharmaceutical market, the drug is presented in the form of a suspension for injection. The drug can be administered intramuscularly, intraarticularly and periarticularly. One ampoule contains 1 ml of suspension. The drug is packaged in packages of one and 5 ampoules.

The active component of the drug is betamethasone. In Diprospan it is presented in two forms:

Betamethasone dipropionate, the content of which is 5 mg per ampoule. This substance helps prolong the therapeutic effect of the drug.
Betamethasone sodium phosphate, the content of which is 2 mg in one ampoule. This component allows you to quickly achieve a positive effect.

The components of Diprospan are completely eliminated from the body in the form of inactive metabolic products through the kidneys. For this reason, the use of the drug is contraindicated in patients with kidney disease or failure.

Drug differences

The difference between Betaspan and Diprospan is only in the name, packaging and manufacturer. Diprospan is produced by a Swiss company, and Betaspan is produced directly in the Russian Federation. Both drugs are dispensed from pharmacies only with a prescription from the attending physician.

Analogues of medications are also other corticosteroid drugs that have a strong anti-inflammatory effect on joints (for example, Flosteron), as well as a natural hormone of the endocrine gland.

Compatibility with drugs and alcohol

It is not recommended to combine the medicine with diuretics. This combination can lead to the development of hypokalemia (potassium deficiency in the body). It is also not possible to combine the drug with Phenobarbital, Ephedrine, Rifampicin, which help weaken the therapeutic effect of Betaspan.

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Concomitant use of the drug with androgens, oral contraceptives, anabolic steroids, immunosuppressants, and antipsychotics leads to increased side effects. If you have hypoprothrombinemia, you must be careful when taking acetylsalicylic acid and Betaspan in parallel, due to the likelihood of bleeding.

The combined effect of the drug with alcohol
poses a danger to the patient's health.
This combination can lead to an increase in the frequency of side effects, severe gastrointestinal ulcers, and severe intoxication.

The use of the drug can influence the speed of reactions, which is important when driving vehicles or other mechanisms. In this regard, during the treatment course it is worth refraining from these types of activities.

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Infants whose mothers were treated with significant doses of the drug during pregnancy are recommended to be examined for the presence of congenital diseases (cataracts, adrenocortical insufficiency).

Attention! After long-term drug treatment for children, the instructions for use of Betaspan recommend monitoring their growth and development, as there are risks of inhibiting the normal course of these processes.

Characteristics of Diprospan

Diprospan is a synthetic glucocorticosteroid. It is an analogue of the natural hormone of the adrenal glands. At the same time, Diprospan has a pronounced anti-inflammatory effect, which determined the scope of its use. The drug is also used in the treatment of allergies, since it suppresses the corresponding reactions and has an immunosuppressive effect. It also relieves pain that accompanies inflammatory diseases.

After taking Diprospan, if the dosage has not been exceeded, no side effects occur.

Only long-term use of the product in large quantities leads to such unpleasant consequences. Therefore, it is necessary that the doctor be able to select the necessary dosage that does not give side effects, but provides a therapeutic result. Then the drug can be taken by patients from all age groups.

The advantage of Diprospan compared to other drugs from this group is precisely that it rarely gives side effects and does not have a depressing effect on the pituitary gland.

Diprospan has a pronounced anti-inflammatory effect.

Indications for the use of Diprospan:

pathologies of organs and tissues of rheumatic or simply inflammatory origin - arthritis, osteoarthritis, gout, bursitis, lumbago;
Bekhterev's disease;
allergic reactions, including bronchial asthma, atopic dermatitis, urticaria, allergies to insect bites and medications (you need to administer an ampoule of Diprospan - and in a matter of minutes the swelling begins to subside).

Contraindications for the prescription of Diprospan may be diseases of the thyroid gland (although it is a synthetic hormone that should not have a direct effect, there is an indirect effect), fungal and viral infections, and pathologies of the gastrointestinal tract. Side effects include skin reactions, increased blood pressure and intraocular pressure.

Diprospan is most often used in the form of a suspension for intramuscular or intra-articular injections. However, the drug is also included in the ointment, where it is used in combination with salicylic acid (Diprosalic).

What is the difference?

Despite the same “filling”, these drugs are still significantly different. First of all, the security profile .

The production of any medicinal substance must be carried out in accordance with federal law dated 04/12/2010 N 61-FZ “On the circulation of medicines”. Based on the results of the examination, registration is granted to the drug, after which it can be sold in pharmacies.

Both drugs are registered and have a license number.

Nevertheless, a high-quality manufacturer who cares about the health of its consumers conducts various clinical trials before releasing the drug. The quality and safety of diprospan is checked at the world level. The research results can be found in the public domain on the Internet. In addition to the Russian Federation, the drug substance is exported to many other countries, and a production error will cost the Belgian manufacturing company many billions.

In addition, clinical studies of the comparative effectiveness of diprospan in comparison with other drugs are constantly being conducted.

The pharmaceutical company that produces Betaspan is not so popular. There is not a single clinical study regarding the safety profile of this drug. There is also no officially registered instruction.

The smaller evidence base for betaspan determines its lower cost.

Indications for injections

Injections are often included in a comprehensive scheme for eliminating conditions that require quick and effective therapeutic intervention. These include:

endocrine pathologies (acute adrenal insufficiency, bilateral adrenalectomy, congenital adrenal hyperplasia, insufficient function of the adrenal cortex);
diseases of joints and muscle tissue (arthritis, bursitis, fibrositis, myositis, calluses);
skin diseases (Stevens-Johnson syndrome, dermatitis, complicated types of psoriasis, dermatomycosis, neurodermatitis, eczema);
respiratory diseases (pneumonia, tuberculosis, berylliosis);
ophthalmological disorders (iridocyclitis, corneal ulceration, optic neuritis, conjunctivitis);
allergic conditions (rhinitis, allergies to medications, Quincke's edema);
hematological pathologies (thrombocytopenia, erythroblastopenia, hypoplastic erythroid anemia);
collagenosis (rheumatic carditis, systemic lupus, dermatomyositis);
types of shock (burn, anaphylactic, traumatic, postoperative).

Betaspam instructions for use
Injections of the drug are also indicated for eliminating cerebral edema, cancer, and ulcerative lesions of the gastrointestinal tract. In prematurely born babies, the drug provides high-quality prevention of the development of distress syndrome.

The instructions for use indicate that the product should be administered only to the site of the disease - into the joints, skin, intramuscularly. Subcutaneous and intravenous use of the drug is prohibited.