"Strepsils" for children over 3 years old: instructions for use, dosage, reviews

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Green Elena Stanislavovna

Otolaryngologist of the second category

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Strepsils lozenges for cough and sore throat are a combined medicine with bactericidal and bacteriostatic action. The drug is prescribed for symptomatic treatment of pain and sore throat associated with infectious lesions of the oral cavity and upper respiratory tract. Its effectiveness is due to the presence of antifungal components in the composition, which allows it to be used for coughs caused by bacterial infections and complicated by Candida fungi.

Strepsils lozenges are an affordable cough medicine that is used for the symptomatic treatment of adults and children. You can buy it at a pharmacy without a prescription, but consulting a doctor if signs of the disease appear is mandatory.

Varieties

Among the products under this brand are the following dosage forms:

1. Strepsils lozenges:

• "Original".
• "Soothing effect with honey and lemon."
• "With vitamin C and orange flavor."
• “For sore throat and nasal congestion with eucalyptus and menthol.”
• "Sugarless".
• "With a warming effect."
• "Strepsils plus".
• For children over 5 years old.
• "Strepsils intensive".

2. Strepsils plus throat spray.

All of these products help relieve the symptoms of upper respiratory tract diseases and are pleasant to the taste.

Indications and contraindications for use

Strepsils is prescribed for cough only as part of complex therapy for the corresponding disease of the respiratory system.

Indications for use of the medicine are:

• pathological conditions accompanied by pain in the mouth or throat;
• tonsillitis;
• laryngitis;
• pharyngitis.

to relieve cough or oropharyngeal pain is contraindicated

Why does my throat hurt?

The causes of pain and discomfort in the throat can be viruses or bacteria. The latter microorganisms cause diseases of the upper respiratory tract only in 10% of cases.

The main cause in the vast majority is a viral infection. In this case, the use of antibiotics is unjustified and useless. If the doctor stated that the disease occurred as a result of bacterial activity, then antiseptic drugs are indicated for the patient in therapeutic measures. Therefore, you should not engage in self-diagnosis. You must take antimicrobial drugs only with a doctor's prescription. What is better to use: products from the Strepsils line, analogues or synonyms of this medicine, this should be decided by a medical specialist.

Side effects

After using Strepsils Intensive lozenges containing honey and lemon, some patients experience a feeling of tongue numbness. This phenomenon is temporary and is caused by certain components of the drug. Sometimes there is a change in taste sensations.

Decreased sensitivity of the tongue occurs when lozenges containing lidocaine are used for treatment. Therefore, it is recommended to take hot food with caution.

Side effects characteristic of drugs from the NSAID category occur in case of an overdose of the drug (taking 12 or more lozenges during the day). From the digestive tract, symptoms such as dyspepsia, diarrhea, nausea, and abdominal pain are observed. With prolonged use, exacerbation of peptic ulcer disease and internal bleeding are possible.

Allergic skin reactions (urticaria, rash, itching) may also appear during treatment with Strepsils Intensive lozenges. The instructions for use warn that in severe cases the development of anaphylactic shock and Quincke's edema is possible.

An increased dose of flurbiprofen (more than 2 g per day) can lead to drowsiness, headache, and discomfort in the epigastric region. More rare side effects include tachycardia, renal dysfunction, and heart failure. Patients suffering from diabetes should be aware that throat lozenges contain sugar.

How does Strepsils work?

The main active ingredients of the drugs of the Strepsils brand, reviews of which are positive, are 2,4-dichlorobenzyl alcohol and amylmetacresol. These substances provide a local antibacterial and fungicidal effect. They are active against a fairly large group of gram-positive and gram-negative microorganisms. Their action is based on the following effects:

• bacterial cell membranes are destroyed;
• dehydration of microorganism cells occurs.

As a result of these actions, the bacteria die. These active substances are highly effective against streptococci, diplococci, staphylococci, microorganisms of the genus Aerobacter, Klebsiella, Proteus. Strepsils, which is quite simple to use, also works well with Candida-type fungi. This quality is very important when a fungal infection is added to the bacterial one.

Strepsils lozenges are presented on the pharmaceutical market in nine types.

In each of them, the active substances are 2,4-dichlorobenzyl alcohol at a concentration of 1.2 mg and amylmetacresol, the content of which in the drug is 0.6 mg, supplemented with various components to relieve certain symptoms.

Release form and composition

• lozenges (lollipops): round, flat-cylindrical, with the letter S on both sides; bluish-green in color, the edges of the tablet may be uneven, there may be small air bubbles inside the caramel mass, and a white coating on the surface; have a characteristic menthol odor (4, 6, 8 or 12 pcs. in blisters; 1, 2 or 3 blisters in a cardboard pack/metal box/laminated foil package/attached to a cardboard cover);
• dosed spray for topical use: a red, transparent solution with a characteristic odor [20 ml of spray or 70 doses (≥140 clicks on the valve) in glass bottles, sealed with a white plastic cap with a dispenser closed with a white plastic cap; 1 bottle in a cardboard box].

Composition of 1 lozenge:

• active ingredients: lidocaine hydrochloride monohydrate – 10 mg; amylmetacresol – 0.6 mg; 2,4-dichlorobenzyl alcohol – 1.2 mg;
• auxiliary components: sodium saccharinate, tartaric acid, levomenthol, peppermint leaf oil, anise seed oil, indigo carmine, quinoline yellow dye, liquid dextrose (dextrose, poly- and oligosaccharides), liquid sucrose.

Composition of 0.5 spray dose (1 press on the valve):

• active ingredients; lidocaine – 0.78 mg; amylmetacresol – 0.29 mg; 2,4-dichlorobenzyl alcohol – 0.58 mg;
• auxiliary components; glycerol, levomenthol, citric acid, sorbitol solution 70% (uncrystallized), saccharin, peppermint leaf oil, anise seed oil, azorubine (carmosine edicol), concentrated hydrochloric acid, sodium hydroxide, purified water, ethanol 96%.

Classical

"Strepsils Original" is the classic form of the drug. Along with the main active ingredients, the lollipops contain essential oils of peppermint and anise. These auxiliary components help soften the mucous membrane of the mouth and throat by stimulating the activity of the salivary glands. In addition to this effect, essential oils provoke local tissue hyperemia, which promotes more intense blood circulation. All these effects help the body cope with the disease faster.

Compound

The active ingredients of Strepsils in any of its forms are dichlorobenzyl alcohol with amylmetacresol. Depending on the purpose, other ingredients are added. For example, “Strepsils” with menthol and eucalyptus contains levomenthol, while the analogue with vitamin C includes ascorbic acid. Strepsils-plus spray contains lidocaine hydrochloride, which provides an anesthetic effect for sore throat.

Lollipops, just like the spray, contain additional ingredients. For example, children's "Strepsils" includes tartaric acid along with flavoring, coloring, sodium saccharinate, etc. "Strepsils-Intensive" contains levomenthol in combination with honey, sucrose, acrogol, "Strepsils-plus" adds peppermint oil, and, In addition, anise seeds, citric acid and purified water are included directly in the spray.

The herbal additives in the Strepsils line are proven plants used in folk medicine, and at the same time in the field of modern pharmaceuticals. They help very well with pain, redness in the throat, in case of dry irritated cough, dryness and burning sensations.

For example, eucalyptus is highly valued due to its high content of essential oils, which give the plant expectorant, anti-inflammatory and bactericidal properties. It also contains a natural antiseptic, which is cineole. Another herbal component is peppermint. Its essential oil has soothing, antiseptic and expectorant effects.

And, of course, since ancient times people have known the healing properties of honey. When mothers and fathers have coughs and severe pain in children, they give them milk with honey, which softens and soothes the mucous membrane, stopping the cough and reducing pain. Thus, in the products of the Strepsils line, the substances that were developed by pharmacologists complement the drugs known to the folk recipe. Their effectiveness and safety do not need to be confirmed.

With vitamin C

In this drug, the main active ingredients are supplemented with vitamin C, which is considered a highly effective immunomodulator.

Vitamin C also reduces capillary permeability, fights inflammation and allergic manifestations. As a result, the intensity of prostaglandin synthesis decreases, swelling subsides, and the patient’s condition improves. This drug "Strepsils" has positive reviews. It is very popular for treating throat diseases. Its composition is enriched with essential oils of anise and orange, which soften the mucous membranes and tone the human body.

When will the spray help?

To relieve a sore throat and eliminate pathogens of the inflammatory process, you can use Strepsils Intensive or Plus. However, the drug in the form of a spray has a wider range of therapeutic effects and is often prescribed not only for the treatment of colds, but also in the treatment of dental diseases of the oral cavity (periodontitis, stomatitis).

"Strepsils Plus" is indicated for use by patients suffering from irritation of the mucous membrane of the mouth and larynx due to smoking or inhalation of harmful (allergic) substances. The active ingredients suppress the development of streptococci, staphylococci, and fungal pathogens.

Menthol and eucalyptus

The combination of 2,4-dichlorobenzyl alcohol, amyl methacresol with menthol and eucalyptus essential oil has a good antibacterial, analgesic, anti-inflammatory, and slight expectorant effect. This medicine is excellent for nasal congestion. Essential oils of eucalyptus and menthol affect blood vessels, and they narrow.

Thus, the swelling of the nasal mucosa subsides, breathing is restored, and the condition improves.

Reviews of Strepsils for children over 3 years old

Doctors in the reviews recommend that if children have a sore throat, gargle with medicinal plants, alternating them with taking suitable medications that alleviate the condition. For example, specialists’ comments often recommend Strepsils spray or tablets.

Parents, in turn, confirm the effectiveness of these lozenges in treating the throat of children. It is often noted that timely treatment with this drug does not allow the development of purulent sore throat in young children. It is reported that as part of therapy, purulent plaque in children disappears, swelling of the throat mucosa subsides and children begin to calmly swallow, drink and eat solid food.

Strepsils is prohibited for use in children over 3 years of age, but parents still give them this medication in the form of lozenges. The main thing is to make sure that the child does not choke on the candy.

Lemon and honey

The combination of lemon and honey is a good tradition in the treatment of colds. That is why this combination of products was included in the Strepsils product. Contraindications to bee products may be a serious prerequisite for refusing to use these antiseptic lozenges.

Thanks to the combination of amylmetacresol, 2,4-dichlorobenzyl alcohol with honey, lemon and peppermint essential oils, this drug "Strepsils" produces an anti-inflammatory, softening and bactericidal effect.

Also, these lozenges help to establish metabolic processes, increase resistance to infections and stimulate the body to cleanse itself of toxins.

Vokasept for sore throat

An effective Indian medicine, Volkasept, is available in the form of lozenges and syrup. The active ingredients are the same as those in the Strepsils Plus spray - amylmetacresol and dichlorobenzyl alcohol. Excipients enhance the therapeutic activity: essential oils of mint and anise, menthol, eucalyptus oil.

Vokasept lozenges and syrup, like Strepsils Intensive tablets, are combined medications that have an antiseptic and analgesic effect. The active components have an effect on most gram-positive and gram-negative microorganisms. With timely treatment, the drug helps prevent the addition of a bacterial infection to a viral disease.

Lozenges and syrup should be used for the symptomatic treatment of inflammatory processes in the upper respiratory system. Vokasept is effective for tonsillitis, pharyngitis, and laryngitis.

Additional component

The product line of this brand includes the item “Strepsils Plus”, the instructions for which depend on the form of the product. Medicines, which are available in the form of lozenges and sprays, show high effectiveness in the treatment of infectious diseases of the mouth and throat. The composition of these drugs, in addition to 2,4-dichlorobenzyl alcohol and amylmetacresol, includes lidocaine, as well as essential oils of anise, peppermint and levomenthol.

Lollipops are the standard form of release of this brand, but Strepsils spray, the use of which is prescribed for the same symptoms, is a completely different form. In addition to the antiseptic, vasoconstrictor and local irritant effect, it has an analgesic effect due to the anesthetic lidocaine. Thanks to this medicine, significant discomfort in the throat can be eliminated. However, caution should be exercised when using a product such as Strepsils spray. Reviews of this drug allow us to conclude that this pharmaceutical product can cause an allergic reaction to the components, as well as numbness of the mouth and larynx as a result of exposure to lidocaine.

Description of the dosage form

Cough lozenges for resorption are produced in blisters of 8 pieces in a cardboard package.

Strepsils lozenges contain 2 active ingredients:

• 2, 4-dichlorobenzyl alcohol - leads to the complete destruction of pathogenic microorganisms due to their dehydration;
• amylmetacresol - destroys the walls of pathogens, has bactericidal and bacteriostatic properties.

Due to the activity of these components against most gram-positive and gram-negative organisms, the use of Strepsils for cough not only relieves the inflammatory process of the larynx, but also acts directly on the cause of the disease.

Many cough medications are indicated only to suppress the cough reflex and thin the mucus, while Strepsils inhibits the spread of pathogenic microorganisms, which at the same time prevents complications.

There is evidence that the use of lozenges containing amylmetacresol and 2, 4-dichlorobenzyl alcohol is effective in cases of infection with a virus that causes acute respiratory infections. However, the virucidal effect of this drug does not apply to rhinoviruses and adenoviruses, which often cause ARVI. Fungi of the genus Candida, which provoke coughing during fungal pharyngitis, are also sensitive to the antiseptics included in Strepsils lozenges.

There are several varieties of lollipops called "Strepsils".

1. Original - they additionally contain mint and anise essential oils. Once on the mucous membrane, they envelop the throat, which promotes pain relief and increased salivation. Active secretion of saliva is necessary for the natural cleansing of the mucous membrane and its softening.
2. Menthol + eucalyptus - have a more pronounced analgesic effect, enhance the antibacterial and anti-inflammatory effect.
3. Lemon + honey - help relieve inflammation of the mucous membranes, help speed up recovery from infectious pathologies accompanied by cough.
4. With vitamin C - ascorbic acid improves immune defense, reduces the severity of edema and inhibits inflammatory processes.
5. Lemon + herbs - help cope with redness of the throat, reduce soreness and soreness, stimulate expectoration during a wet cough.

Contraindications

Despite the fact that the drug is local and its active ingredients practically do not penetrate into the bloodstream, in some cases you should take the drug "Strepsils" with extreme caution. Contraindications to this pharmaceutical product are as follows:

• the presence of sensitivity to any component included in the composition;
• Children under 6 (and Strepsils Plus up to 12) years old are also contraindicated in all of the above remedies.

This medicine should be used with extreme caution by pregnant and lactating women. You should consult with your doctor about the suitability of Strepsils, who evaluates each situation individually.

What does it contain?

Which component provides the therapeutic effect of Strepsils Intensive? The composition of the lollipops is indicated on each package. The manufacturer uses flurbiprofen as an active ingredient, a non-steroidal anti-inflammatory drug with pronounced analgesic properties.

The mechanism of action of the component is associated with inhibition of prostaglandin synthesis and inhibition of COX. One tablet contains 8.75 mg of the active component flurbiprofen.

Auxiliary components are macrogol 300, levomenthol, liquid sucrose, honey, dextrose, lemon flavor, potassium hydroxide. Due to the fact that the product is available in the form of lozenges, the components of the drug can get into the most difficult to reach places. A properly selected dosage of substances in the composition provides a powerful therapeutic effect.

Features of application

Lollipops of all the above types should be dissolved 1 piece after 2-3 hours. It is very important to follow the dosage: you are allowed to take no more than 8 tablets per day.

Strepsils spray is used to irrigate the area with inflammation by double pressing the dosing head of the bottle.

The procedure can be repeated after 3 hours, but no more than 6 times a day. The duration of treatment with this drug for more than 5 days should be agreed with your doctor.

What is used in pediatrics?

Strepsils Intensive lozenges are prescribed to children only after reaching 12 years of age. The spray has a similar age limit. For younger patients, the manufacturer offers to purchase “Strepsils for Children”. Lollipops can be used for inflammatory processes in the throat area in children over 6 years of age.

When treating with the drug, you must strictly adhere to the dosage. Children over 12 years of age are allowed to dissolve 1 Strepsils Intensive lozenge. The instructions for use recommend doing this every 2-3 hours at the initial stage of development of the disease.

The spray is used to irrigate the oral cavity every 3-4 hours. One dose corresponds to two presses on the nebulizer. More than 6 doses per day are prohibited. The duration of treatment with the spray should not exceed 5 days. Tablets are used for treatment only for three days.

For children

Due to the fact that children under 12 years of age also need an effective local medicine for diseases of the mouth and throat, Reckitt Benckiser has created a special drug “Strepsils for Children”. The active ingredients in it are the same as in all other lollipops, and in the same concentration, but do not contain sugar or essential oils. This means that the tablets do not contribute to the development of caries and minimize the risk of an allergic reaction. Any child will like the taste of lemon or strawberry and will make treatment enjoyable.

Side effects

Using Strepsils for coughing can cause an allergic reaction and irritation of the mucous membrane. Less often, there is a risk of distortion of taste sensations and impaired sensitivity of the inner side of the cheek.

The observed hypersensitivity reaction manifests itself as follows:

• bronchospasm, shortness of breath;
• anaphylaxis;
• nonspecific allergic reaction;
• skin manifestations: itching, redness, urticaria;
• Quincke's edema;
• extremely rare: bullous dermatitis, erythema multiforme, epidermal necrositis.

From the gastrointestinal tract, adverse reactions manifest themselves in the form of dyspepsia, diarrhea, vomiting, exacerbation of peptic ulcer disease and gastritis.

A special case

A completely different remedy from other products of this brand is Strepsils Intensive, reviews of which allow us to draw conclusions about the effectiveness of this drug. Its peculiarity is that it uses flurbiprofen at a concentration of 8.75 mg as the main active ingredient. This component is a non-steroidal anti-inflammatory drug and reduces the intensity of prostaglandin production. The effect of the drug occurs within 15 minutes after taking it and lasts about 3 hours. The medicine eliminates inflammation and relieves pain in infectious and viral lesions, as well as in occupational diseases of the oropharynx and smoker's cough.

Due to the fact that Strepsils Intensive, reviews of which indicate its popularity in our country, does not contain antibacterial components and does not have an antiseptic effect, it has a wider range of contraindications, including:

• stomach and duodenal ulcers;
• pregnancy and lactation;
• children's age up to 12 years.

Instructions for use Strepsils

The product is prescribed for local use. The average price is 190-240 rubles. 1 package contains 24 units of medication, 12 in 1 blister.

For children

The drug is prescribed to children from 5 to 6 years of age. The resemblance to candy increases the child’s interest in the treatment. Dose – 1 tablet every three hours. The daily amount of lozenges should not exceed 8 units of medication. The duration of the therapeutic course is 3 days. Extension of treatment is discussed with the doctor. Lollipops should not be used for children under 5 years of age due to the risk of ingesting large particles of the medication and causing suffocation.

For adults

Instructions for use include the prescription of Strepsils to eliminate cough in adult patients according to the above scheme.

During pregnancy and lactation

Cough medicine during pregnancy and lactation is used only after consultation with a doctor. The doctor evaluates the risk-benefit ratio for the mother and child. In 90% of cases, pregnant or lactating women do not notice negative consequences of using the medicine.

Analogs

Among the many drugs aimed at easing the suffering of a person with a sore throat, there is not only the Strepsils line of products. Analogs of these pharmaceutical products can also cope with ailments of the oropharynx. These drugs include:

• Spray and solution "Angilex".
• Lozenges "Neo-angin".
• "Grammidin."
• Spray "Inhalipt".
• Sage tincture.
• "Theraflu LAR" - tablets and throat spray.
• “Gorlospas for children”, etc.

Your doctor will decide which drug is appropriate for your specific situation.

How to replace Strepsils Intensive?

Finding an analogue of the original product is not at all difficult. Pharmacies sell a huge number of all kinds of medications to help cope with a sore throat. Based on flurbiprofen, you can purchase the medicine “Strepfen” (England), available in the form of lozenges. The drug has a slight antipyretic effect and also quickly eliminates pain.

Effective substitutes include the following medications:

1. "Hexoral Tabs."
2. "Vocasept."
3. "Angi Sept."
4. "Theraflu LAR".
5. "Agisept."
6. Trisils.
7. "Isla-mint."
8. "Sebidin Plus".

Properties of the drug

Strepsils is a combination drug that belongs to the group of antibacterial agents. This medicine can relieve the patient of a sore throat by suppressing the inflammatory process of the oropharynx. Such effects are achieved thanks to two active components: dichlorobenzyl alcohol and amylmetacresol. Both of these substances have an antimicrobial effect.

They are able to destroy gram-positive and gram-negative bacteria. As a result, the growth and reproduction of pathogenic microorganisms is suppressed.

Drug analogues

Faringosept, Strepsils spray, Grammidin and Septolete are created for the treatment of various infectious diseases. Manufacturing companies have created a wide range of products with different tastes for the most convenient and enjoyable treatment.

Strepsils or Septolete: which is better? Both products have similar effects and properties, the only difference between them is the price and the active substance. The active substance in Strepsils is amylmetacresol and 2,4-dichlorobenzyl alcohol, in Septolete it is benzalkonium chloride and thymol.

The cost of the first medicine is indicated in the lower section, the second drug costs from 132 to 145 rubles (30 lozenges). That is, it is cheaper to buy Septolete. And according to the mechanism of action, the medications are equal.

Faringosept or Strepsils: which is better? The first drug is a strong bacteriostatic. Its active substance is ambazone monohydrate. The medicine eliminates harmful microorganisms and prevents their proliferation in the oral cavity.

The medication fights against staphylococcus, streptococcus and pneumococcus. Unlike Strepsils, Faringosept is prescribed for children from 3 years of age. The average cost in pharmacies in the Moscow region is 140 rubles per package of 20 lozenges.

That is, it is more profitable than Strepsils. Both drugs have different compositions; if the patient has a bacterial infection, then it is better to use Faringosept, it works faster and more efficiently.

Strepsils or Grammidin: which is better? The difference between Grammidin and Strepsils is that it has an antibiotic as an active component. It has both antiseptic and antibacterial effects.

It is the cheapest among the products under consideration; the cost of Grammidin is about 120 rubles. It is much more effective than Strepsils because it contains the antibiotic grammidin C.

Instructions for use for children and adults contain information that lozenges and lozenges do not affect other medications taken simultaneously with them. The medicine is available without a prescription.

The medication is stored at room temperature in a place protected from children. Since the tablets taste good, a child who does not understand that they are not candies can eat more of them than they should, resulting in an overdose.

The shelf life of Strepsils is no more than three years.

Strepsils intensive lozenges and tablets are very effective, so their cost in pharmacies is a little high. The price of the medicine ranges from 173 to 480 rubles. The cost of the drug depends on the number of tablets in the package and their taste.

If there is a need to change the medication, use one of the suggested remedies below. Strepsils analogues:

• Angi sept;
• Gripcold;
• Grammidin;
• Decathylene;
• Ingaflu;
• Angilex;
• Yox;
• Coldact;
• Lisak;
• Agisept;
• Septolete;
• Faringosept and others.

Similar medicines are medicines that have the same international nonproprietary name or ATC code. Before using them, consult your physician or pediatrician for advice.

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In the detailed instructions for use of Strepsils, information about the drug interactions of lozenges with representatives of other pharmacological groups is completely absent. This means that such an antiseptic drug is involved in complex therapy without harm to the patient’s health. It is important to remember that self-medication is contraindicated.

Strepsils price

The price of Strepsils No. 24 in Russia ranges from 170-215 rubles. In Ukraine, such packaging will cost 50-70 hryvnia.

When is it prescribed?

Lollipops are recommended for use for the symptomatic treatment of pain in the throat and oral cavity. The prerequisites for the appearance of pain can have both infectious and bacterial etiologies. The symptom often occurs with influenza, ARVI, tonsillitis, laryngitis.

It should be borne in mind that the manufacturer strongly does not recommend self-medication, and you should first visit a doctor to determine the true cause of the discomfort in the throat. Lozenges can be used as part of a complex treatment of pain syndrome.

Pharmacological properties

Cetylpyridinium chloride is an antiseptic from the group of quaternary ammonium compounds. It acts as a cationic detergent. The quaternary ammonium compound binds to the surface of bacterial cells, penetrates it and connects with the cytoplasmic membrane of the microorganism. As a result of binding, the cytoplasmic membrane of the microorganism increases permeability to low molecular weight ingredients, mainly potassium ions. Then quaternary ammonium compounds penetrate the cell, disrupting the functions of the cell, thus destroying it. Cetylpyridinium chloride has a broad spectrum of antimicrobial action; The bactericidal effect on gram-positive bacteria (in particular Staphylococcus) is considered the most pronounced. Gram-negative bacteria are moderately sensitive to cetylpyridinium chloride, while some strains of Pseudomonas are relatively insensitive. Cetylpyridinium chloride also has antifungal activity (particularly against Candida and Saccharomyces) and viral activity against some enveloped viruses. Benzocaine blocks the conduction of nerve impulses, including pain impulses, thereby eliminating the sensation of pain. Blocking the conduction of pain impulses occurs due to a decrease in the permeability of nerve cell membranes to sodium ions. There is no data in the literature on the pharmacokinetics of cetylpyridinium chloride. Most data on the pharmacokinetics of quaternary ammonium compounds come from animal studies. It is known that quaternary ammonium compounds are poorly absorbed (10–20%), and the part that is not absorbed is excreted unchanged in the feces. Data in the literature on the pharmacokinetics of benzocaine are also very limited. Some local anesthetics, including benzocaine, are known to be very poorly soluble in water, so their absorption is minimal. Benzocaine, which is absorbed, is mainly hydrolyzed by cholinesterases in the blood plasma and is metabolized to a lesser extent in the liver. Decomposition products are excreted in the urine.

Pharmacological group

Septolete total has local anesthetic, antifungal, antibacterial and anti-inflammatory properties.

Benzydamine is a non-steroidal anti-inflammatory drug that provides analgesic and anti-inflammatory effects.

Cetylperedinium chloride is an antiseptic substance from a number of quaternary ammonium compounds. The presence of this component in the drug is due to antifungal, antimicrobial and virucidal effects.

Cetylperedinium chloride is not absorbed. Benzydamine is absorbed into the systemic circulation through the oral mucosa, but its amount is not sufficient for TOO to have a systemic effect on the body.

Danger of overdose

Overdose occurs in very rare cases. Typically, its symptoms are observed when consuming more than ten lozenges per day.

Signs of overdose include:

• diarrhea;
• vomit;
• skin rashes.

If these signs occur, stop using the medication. It is recommended that in case of overdose, drink plenty of fluids. Consultation with your attending physician is also advisable.

In case of an overdose of an aerosol, the following reactions may occur:

• increased sweating;
• convulsions;
• vomit;
• shortness of breath;
• lack of coordination;
• nervous overexcitation;
• decrease in pressure;
• tremor.

If such symptoms are observed, then medications are prescribed for symptomatic therapy.

The danger of an overdose of the spray is that high doses of cetylpyridinium can lead to serious complications. The development of coma cannot be ruled out. Exceeding doses of this substance can be fatal.

Strepsils, reviews

Discussions around Strepsils continue on review sites. Opinions are mixed. Below are some typical comments.

Olga, 23 years old: “I always use Strepsils. Lollipops are good for relieving sore throats. With them I cough and get sick less often.”

Andrey, 42 years old: “The drug is too expensive. 200 rubles for candies that didn’t help me. I don't recommend it."

Oleg, 32 years old: “Standard Strepsils is the best remedy for me for a sore throat and dry cough. Other flavors don't help. I am a believer in the original medicine."

Indications for use

Strepsils is prescribed to patients suffering from the following pathologies:

Strepsils cough lozenges

• tonsillitis (tonsillitis);
• laryngitis (false croup);
• pharyngitis;
• tracheitis;
• stomatitis;
• periodontal disease;
• gingivitis.

A significant reason for prescribing Strepsils is an infectious infection accompanied by damage to lymphoid tissue. The list of indications for use includes pathologies of a fungal nature, sore throat during colds, aphthae, wet as well as dry cough that irritates the throat. Strepsils is included in treatment complexes to soften affected mucous membranes. The medication is combined with powerful antiseptics and antibiotics, which are characterized by a wide spectrum of action.

Lollipops are indicated for use for sore throat

The positive effect on cough is due to the influence of essential oils. The patient’s well-being improves due to the timely elimination of irritating factors and increased coughing. Strepsils is prescribed when the first symptoms appear in a child or adult. The drug is allowed to be used for preventive purposes (after surgery in dentistry, in ENT practice).

Restrictions on use recommended by the instructions

Before using the drug "Septolete Total", the indications for use must be studied

But no less attention should be paid to contraindications. If you have at least one, then these lozenges will not work

On the contrary, they can aggravate your condition. Even if the medicine is prescribed by a doctor, you should not be lazy and refuse to read the instructions.

The abstract prohibits the use of lozenges for the treatment of children. The question of clarifying the limited age remains open to this day. Initially, Septolete Total was not recommended for use by people under 18 years of age. Septolete Total, produced since 2016, can be used from 12 years of age. The medicine is not prescribed in case of hypersensitivity to its components. Persons with lactose and fructose intolerance, as well as pregnant women, should first consult a doctor. During lactation, the use of the medication is not contraindicated, since only a small amount is often absorbed into the bloodstream.

During pregnancy

During pregnancy and lactation, such pharmaceutical use is not prohibited. Treatment for medical reasons takes place under strict medical supervision. Clinical studies have not been conducted in these categories of patients, so before starting a course it is important to make sure that the benefit to the mother's health is higher than the potential harm to the unborn or infant.

“Can Strepsils be used during pregnancy and lactation?” or “Can pregnant women take throat lozenges?” - the most frequently asked questions about this product. These questions should be resolved only by the attending physician, based on the patient’s condition, course of the disease, medical history and possible risk to the child or fetus.

Description of the product

The drug belongs to antiseptic drugs that are prescribed for complex therapy of otolaryngological diseases. Used for inflammation of the oral cavity in dental practice.

The medicine is intended for local use. Septolete is an effective remedy for bacterial infections, since it acts directly on the site of inflammation.

Composition and dosage forms

The medicine contains the following active ingredients:

• benzalkonium;
• levomenthol;
• eucalyptus leaf oil;
• thymol;
• mint oil.

In addition, the drug in the dosage form of tablets and lozenges contains other auxiliary components:

• lactose;
• sorbitol;
• titanium dioxide;
• magnesium stearate;
• povidone;
• glycerol;
• dyes.

Septolete spray also contains cetylpyridinium chloride.

The drug is available in the following forms:

• in lozenges (available in 15 or 10 pieces in one blister);
• in Septolete tablets for resorption;
• in candies (produced with cherry, lemon and apple flavors and aroma);
• Septolete D (lollipops without added sugar);
• spray.

In the form of a spray and lozenges, you can buy Septolete Total or Septolete Plus at the pharmacy.

STREPSILS

Strepsils.

STREPSILS. Manufacturer: Boots Healthcare International. International name: Various. ATX codes: R02AA20.

Pharmachologic effect. Antiseptic combination drug for local use in ENT practice and dentistry. Has an antimicrobial effect. Active against a wide range of gram-positive and gram-negative microorganisms in vitro; has an antifungal effect. Natural medicinal additives included in the preparation have a softening and decongesting effect on the mucous membrane. The drug is available in five versions, each of which contains various natural additives that provide additional therapeutic effects.

Pharmacokinetics. Due to low systemic absorption, data on the pharmacokinetics of Strepsils are not available.

Indications. Infectious and inflammatory diseases of the oral cavity and pharynx.

Dosage regimen. Adults and children over 5 years old are recommended to dissolve 1 tablet every 2-3 hours. drug. The maximum daily dose is 8 tablets.

Side effect. Rarely: allergic reactions.

Contraindications. Hypersensitivity to the components of the drug.

Pregnancy and lactation. It is possible to use Strepsils during pregnancy and lactation according to indications.

Special instructions. The patient should be informed that if symptoms persist during the use of the drug, are accompanied by high fever, headache or other phenomena, it is necessary to consult a doctor. When prescribing the drug to patients with diabetes, it is necessary to take into account that 1 tablet. contains 2.6 g of sugar (exception: Strepsils with lemon and herbs).

Overdose. Symptoms: gastrointestinal discomfort. Treatment: carry out symptomatic therapy.

Drug interactions. No clinically significant interactions between Strepsils and drugs from other groups have been identified.

Storage conditions and periods. The drug should be stored at a temperature not exceeding 25 °C. Shelf life: 3 years. Conditions for dispensing from pharmacies. The drug is approved for use as a means of OTC.

Release form, composition and packaging. Lozenges. 1 tablet: 2,4-dichlorobenzyl-ethanol 1.2 mg; amylmetacresol 600 mcg; peppermint oil; anise oil; levomenthol; tartaric acid; ponceau edicol; karmazin edikol; hardener made from liquid confectionery sugar and liquid glucose. 8 pcs. — contour cell packaging (1). Cardboard packs. 6 pcs. — contour cell packaging (2). Cardboard packs. 12 pcs. — contour cell packaging (1). Cardboard packs. 12 pcs. — contour cell packaging (2). Cardboard packs. Strepsils with lemon and herbs (no sugar). Lozenges. 1 tablet: 2,4-dichlorobenzyl-ethanol 1.2 mg; amylmetacresol 600 mcg; rosemary oil; tartaric acid; sodium saccharin; maltitol syrup; isomalt; flavoring agents. 8 pcs. — contour cell packaging (1). Cardboard packs. 6 pcs. — contour cell packaging (2). Cardboard packs. 12 pcs. — contour cell packaging (1). Cardboard packs. 12 pcs. — contour cell packaging (2). Cardboard packs. Strepsils with honey and lemon. Lozenges. 1 tablet: 2,4-dichlorobenzyl-ethanol 1.2 mg; amylmetacresol 600 mcg; honey; peppermint oil; lemon oil; tartaric acid; quinoline yellow; hardener made from liquid confectionery sugar and liquid glucose. 8 pcs. — contour cell packaging (1). Cardboard packs. 6 pcs. — contour cell packaging (2). Cardboard packs. 12 pcs. — contour cell packaging (1). Cardboard packs. 12 pcs. — contour cell packaging (2). Cardboard packs. Strepsils with vitamin C. Lozenges. 1 tablet: 2,4-dichlorobenzyl-ethanol 1.2 mg; amylmetacresol 600 mcg; vitamin C (100 mg); anise oil; orange oil; levomenthol; tartaric acid; ponceau edicol; sunset yellow; hardener made from liquid confectionery sugar and liquid glucose. 8 pcs. — contour cell packaging (1). Cardboard packs. 6 pcs. — contour cell packaging (2). Cardboard packs. 12 pcs. — contour cell packaging (1). Cardboard packs. 12 pcs. — contour cell packaging (2). Cardboard packs. Strepsils with menthol and eucalyptus. Lozenges. 1 tablet: 2,4-dichlorobenzyl-ethanol 1.2 mg; amylmetacresol 600 mcg; levomenthol; eucalyptus oil; tartaric acid; indigo carmine; hardener made from liquid confectionery sugar and liquid glucose. 8 pcs. — contour cell packaging (1). Cardboard packs. 6 pcs. — contour cell packaging (2). Cardboard packs. 12 pcs. — contour cell packaging (1). Cardboard packs. 12 pcs. — contour cell packaging (2). Cardboard packs.

In what cases is Strepsils used?

As an independent medication, Strepsils is prescribed by a doctor for the development of acute respiratory viral infections and acute respiratory infections, accompanied by a sore throat. It is prescribed as an additional remedy in complex therapy for diseases such as:

1. Tonsillitis, occurring in both acute and chronic forms.
2. During pharyngitis, gingivitis, stomatitis.
3. It is also used as a prophylactic agent for infection of soft gum tissue after tooth extraction or treatment.
4. When diagnosing a sore throat and after tonsil removal.

It is prescribed to take 1 tablet at an interval of 3 hours, the main thing is not to take more than 8 tablets per day. The tablet is kept in the mouth until it is completely dissolved.

Regarding side effects: they may manifest themselves in the form of allergic reactions, but no other negative phenomena are observed. This is due to the fact that the drug acts locally, without penetrating into the blood.

Dosage with application regimen

Strepsils intensive for children over 5 years of age and adults, it is recommended to take one lozenge every 2-3 hours. The dosage of the medicine should not exceed 8 lozenges.

How to use the medicine? The antiseptic is taken half an hour after or before meals. You cannot chew them; the medicine is dissolved until completely dissolved.

In what cases should you not take Strepsils intensive? What side effects may occur?

It is not recommended to use the drug if you have an allergic reaction to one of the active or additional components. Other contraindications:

• tablets should not be given to children under 5 years of age;
• lollipops are prohibited for use by children under 12 years of age;
• Strepsils should be taken with caution for children and adults if the functioning of the kidneys and liver is impaired.

Attention! One lozenge contains 2.5 grams of sugar. This may be a contraindication for individuals diagnosed with type 1 and type 2 diabetes mellitus. The exception is lemon and herb lollipops.

The medication increases the duration of bleeding and should not be taken simultaneously with anticoagulants. The combination product has no other contraindications.

special instructions

Patients with ulcerative lesions of the mucous membrane of the oropharynx, if symptoms of the disease persist for more than 3 days, should consult a doctor.

The drug should not be used simultaneously with anionic compounds. Since they are contained in toothpastes, it is not recommended to take Septolete Total before or after brushing your teeth.

Septolete total spray contains 96% ethanol in small quantities: 26.760 mg in 1 dose. Contact of the drug with the mucous membrane of the eyes should be avoided. Do not inhale.

Milk may reduce the antimicrobial effect of cetylpyridinium chloride, so it is recommended to refrain from consuming it during treatment.

If hypersensitivity reactions develop, you should immediately discontinue Septolete Total and consult a doctor to prescribe appropriate therapy.

Reception Guide

When prescribing a therapeutic regimen, the doctor must take into account the interaction of Strepsils with other medications:

When taking Strepsils lozenges, you must consider their interaction with other medications.

1. With the simultaneous use of cough lozenges and Flurbiprofen, anticoagulants are activated.
2. Combination with diuretics can slow down their action.
3. It is strictly forbidden to drink Strepsils in parallel with Mifepristone.
4. The same applies to quinolone antibiotics. The “duet” of Strepsils and drugs from this category is fraught with the appearance of convulsive syndrome.

Lollipops are allowed to be given to minors over 5 years of age. You can take no more than 8 pieces per day. Ignoring this recommendation may lead to an overdose. If unpleasant consequences occur, the patient should stop taking the medication. The next step should be a visit to your doctor. He will identify the cause of the ailment and, if necessary, change the drug regimen.

The use of the drug during lactation is allowed with the permission of a doctor.

Pregnancy and lactation are relative contraindications to taking Strepsils. In this case, the drug is allowed to be taken only after consultation with a doctor. Lozenges are often prescribed to older people; adjustments to the daily dose are usually not required.

Strepsils does not affect reaction speed and the ability to concentrate. During therapy, the patient can drive a car and perform his job duties without fear.

Treatment with Strepsils at home (without first visiting a specialist) cannot be continued for more than 3 days. If relief does not occur during this time, you must contact a medical facility. The doctor will extend the therapeutic course or replace the drug.

The risk of side effects is increased in people with allergies. Strepsils contains dyes that can cause complications.

Overdose

Due to the low concentration of both influencing substances in Septolet plus, overdose is not possible when used in recommended doses. Prolonged use of doses higher than prescribed or very frequent use over a short period of time may cause methemoglobinemia. If signs of intoxication occur, use of the medicine should be stopped immediately. Manifestations and symptoms of methemoglobinemia may appear within 45–60 minutes after taking the medicine. Depending on the degree of oxidation of hemoglobin, mild symptoms such as headache, cyanosis, fatigue, asthenia, and shortness of breath may appear. In more severe forms of methemoglobinemia, a feeling of palpitations, convulsions, arrhythmia and coma may occur. Treatment includes the administration of 100% oxygen, in serious cases, also the use of the antidote methylene blue and gastrointestinal lavage, taking activated charcoal. When taking doses significantly higher than recommended, symptoms may occur. gastrointestinal disorders, nausea, vomiting and diarrhea. Cetylpyridinium chloride may cause attacks of nausea and vomiting due to irritation of the gastrointestinal mucosa. Treatment includes the usual procedures of gastric lavage, maintaining breathing and circulation (using vasoconstrictors, if necessary).

Pharmacological properties

pharmacodynamics Mechanism of action.
Benzydamine hydrochloride is an NSAID and a pain reliever.
The mechanism of action is believed to be associated with inhibition of prostaglandin synthesis and, consequently, with a decrease in the severity of inflammation (such as pain, flushing, swelling, fever). Benzidamine hydrochloride also has a moderate local analgesic effect. Cetylpyridinium chloride is an antiseptic of the group of quaternary ammonium compounds. It acts as a cationic detergent. Quaternary ammonium compounds bind to the surface of bacterial cells, penetrate through it and bind to the cytoplasmic membrane of the microorganism. As a result of binding, the cytoplasmic membrane of microorganisms increases permeability to low molecular weight ingredients, mainly potassium ions. Quaternary ammonium compounds then enter the cell, disrupting the functions of the cell and thus destroying it. Cetylpyridinium chloride has a broad spectrum of antimicrobial activity, as well as antifungal activity (for example against Candida
and
Saccharomyces
) and antiviral activity against some enveloped viruses.
The most pronounced bactericidal effect is on gram-positive bacteria (in particular Staphylococcus
).
Gram-negative bacteria are moderately sensitive to cetylpyridinium chloride, whereas some strains of Pseudomonas
are relatively insensitive.
Pharmacokinetics Absorption.
Of the two active substances, only benzydamine is absorbed, so no pharmacokinetic interaction occurs at the systemic level.
The absorption of benzydamine through the mucous membrane of the oral cavity and pharynx is evidenced by the detected amount of it in the blood plasma, which is not sufficient to obtain a systemic effect. Distribution.
The volume of distribution of the drug in the form of lozenges and spray is the same.
Removal
. It is excreted mainly in the urine, mainly in the form of inactive metabolites. T½ and systemic clearance are similar for all dosage forms of the drug.

Indications for use

According to the instructions for use, the drug is indicated in the presence of acute respiratory diseases accompanied by sore throat.
The medication can be used to treat colds of any nature - bacterial, viral and fungal. Strepsils is most often used to treat acute pharyngitis. This disease is accompanied by inflammatory lesions of the pharynx. Acute pharyngitis is characterized by pain in the throat when swallowing or at rest, fever, and redness of the palate.

The drug is also indicated for use in the treatment of acute tonsillitis. This disease is also called “angina”. The pathology is characterized by severe pain in the throat, increased body temperature, and the formation of white plaque on the tonsils.

Strepsils is used much less frequently in dental practice. The drug has a wide spectrum of antiseptic effect, so it can be used to treat infectious pathologies of the oral mucosa and gums.

Acute stomatitis is an inflammatory disease of the oral mucosa. It is accompanied by the formation of an ulcer on the inside of the lip or cheek. With stomatitis, local pain syndrome is observed.

Strepsils is also indicated for the treatment of acute gingivitis. The pathology is characterized by an inflammatory process in the gum area. They turn red, the patient notes pain and swelling. When brushing your teeth, your gums may bleed.