Amoxiclav dosage for adults and children: method of administration, release forms

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Our children are not immune from pathogenic microorganisms that can cause a serious infectious process. And there is no way to do without antibiotics. But while the bacteria grows and sensitivity is determined, precious time is wasted.

The situation can be saved by broad-spectrum antibacterial drugs that act on many strains of microorganisms. In this regard, Amoxiclav has proven itself well, but the instructions for its use are difficult to understand. Let's put it into pieces once and for all.

Operating principle

The antibacterial substance in Amoxiclav - amoxicillin - belongs to the penicillin antibiotics.
It has a fairly wide range of antimicrobial effects, but it is further expanded by the addition of clavulanic acid. This acid combines with enzymes called beta-lactamases. These enzymes are produced by bacteria to reduce the activity of penicillin drugs. Due to the presence of a lactamase inhibitor in Amoxiclav, amoxicillin easily affects a larger list of microorganisms, among which there are different strains of staphylo- and streptococci, as well as Escherichia, Yersinia, Haemophilus influenzae, Listeria, Bacteroides, Peptococcus, Clostridia, Proteus, Enterococcus and many other pathogens.

Reviews of Amoxiclav 875 mg

Patient reviews of Amoxiclav are almost always positive; many note that the drug not only helps, but also has no side effects:

Maria Prokhorova: My child and I just recently suffered from follicular tonsillitis. At the appointment, the doctor recommended Amoxiclav in a dosage of 875, warned in advance that this is a large dosage, but since we are already 12 years old, we can take one tablet a day. Thank God, after a few days the ulcers began to disappear from my throat. And after a week and a half, the son was already like a cucumber. We had no side effects, I recommend Amoxiclav to everyone.
Natalya Ionova: She underwent serious abdominal surgery on her gallbladder, but after the operation, for some reason, some kind of infection developed on the seam. I immediately developed a high temperature, it’s good that I was under observation. They immediately started injecting Amoxiclav. I took this medicine before. Just like last time, it did not let me down and helped me cope with the infection.

Reviews from doctors about Amoxiclav generally coincide with reviews from patients. In any case, the patient should be careful and careful when choosing the appropriate antibiotic.

Overdose

If a child receives more of the suspension than is appropriate for his or her body weight, this will most likely lead to gastrointestinal distress, such as vomiting or diarrhea. In addition, an overdose of Amoxiclav may also cause dizziness, nervous agitation, or insomnia. In some children, exceeding the dose of medication provokes seizures.

Having identified an overdose of the suspension, which occurred less than 4 hours ago, it is recommended to rinse the stomach and give the baby a sorbent so that the drug is less absorbed in the intestines. Next, the child should be monitored and, if necessary, symptomatic therapy should be used. In severe cases, hemodialysis is used because it effectively removes amoxicillin and clavulanic acid from the patient's body.

List of antibiotics

Antibiotics are substances that inhibit the growth of living cells or lead to their death. May be of natural or semi-synthetic origin. Used to treat infectious diseases caused by the growth of bacteria and harmful microorganisms.

Universal

Broad-spectrum antibiotics - list:

Penicillins.
Tetracyclines.
Erythromycin.
Quinolones.
Metronidazole.
Vancomycin.
Imipenem.
Aminoglycoside.
Levomycetin (chloramphenicol).
Neomycin.
Monomycin.
Rifamcin.
Cephalosporins.
Kanamycin.
Streptomycin.
Ampicillin.
Azithromycin.

These drugs are used in cases where it is impossible to accurately determine the causative agent of the infection. Their advantage is a large list of microorganisms that are sensitive to the active substance. But there is also a drawback: in addition to pathogenic bacteria, broad-spectrum antibiotics contribute to suppression of the immune system and disruption of normal intestinal microflora.

List of strong new generation antibiotics with a wide spectrum of action:

Cefaclor.
Cefamandole.
Unidox Solutab.
Cefuroxime.
Rulid.
Amoxiclav.
Cefroxitin.
Lincomycin.
Cefoperazone.
Ceftazidime.
Cefotaxime.
Latamoxef.
Cefixime.
Cefpodoxime.
Spiramycin.
Rovamycin.
Clarithromycin.
Roxithromycin.
Klacid.
Sumamed.
Fuzidin.
Avelox.
Moxifloxacin.
Ciprofloxacin.

Antibiotics of the new generation are notable for their deeper degree of purification of the active substance. Thanks to this, the drugs have much less toxicity compared to earlier analogues and cause less harm to the body as a whole.

Narrowly targeted Bronchitis

The list of antibiotics for cough and bronchitis usually does not differ from the list of broad-spectrum drugs. This is explained by the fact that the analysis of sputum takes about seven days, and until the causative agent of the infection is precisely identified, a product with the maximum number of bacteria sensitive to it is needed.

In addition, recent studies show that in many cases the use of antibiotics in the treatment of bronchitis is unjustified. The fact is that the prescription of such drugs is effective if the nature of the disease is bacterial. If the cause of bronchitis is a virus, antibiotics will not have any positive effect.

Commonly used antibiotic drugs for inflammatory processes in the bronchi:

Ampicillin.
Amoxicillin.
Azithromycin.
Cefuroxime.
Ceflocor.
Rovamycin.
Cefodox.
Lendatsin.
Ceftriaxone.
Macropen.

Sore throat
List of antibiotics for sore throat:

Penicillin.
Amoxicillin.
Amoxiclav.
Augmentin.
Ampiox.
Phenoxymethylpenicillin.
Oxacillin.
Cefradine.
Cephalexin.
Erythromycin.
Spiramycin.
Clarithromycin.
Azithromycin.
Roxithromycin.
Josamycin.
Tetracycline.
Doxycycline.
Lidaprim.
Biseptol.
Bioparox.
Inhalipt.
Grammidin.

The listed antibiotics are effective against sore throats caused by bacteria, most often bethemolytic streptococci. As for the disease caused by fungal microorganisms, the list is as follows:

Nystatin.
Levorin.
Ketoconazole.

Colds and flu (ARD, ARVI)
Antibiotics for the common cold are not included in the list of necessary medications, given the fairly high toxicity of antibiotics and possible side effects. Treatment with antiviral and anti-inflammatory drugs, as well as restoratives, is recommended. In any case, it is necessary to consult a therapist.

Sinusitis

List of antibiotics for sinusitis - in tablets and for injections:

Zitrolide.
Macropen.
Ampicillin.
Amoxicillin.
Flemoxin solutab.
Augmentin.
Hiconcil.
Amoxil.
Gramox.
Cephalexin.
Digital
Sporidex.
Rovamycin.
Ampiox.
Cefotaxime.
Vertsef.
Cefazolin.
Ceftriaxone.
Duracef.

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Indications

Due to its high antibacterial activity, Amoxiclav is in demand for infectious processes of various localizations. The drug is prescribed:

for otitis media, tonsillitis, bacterial sinusitis, retropharyngeal abscess, purulent sore throat and other pathologies of the ENT organs caused by microbial infection;

with bacterial inflammation of large bronchi, bronchioles or lung tissue, which is manifested by cough, thick sputum, fever and other symptoms;
when the urinary system is affected by microbes;

with infection of soft tissues and skin, including inflammation due to secondary infection, for example, with;
with inflammation under the influence of bacteria of bones, ligaments and other connective tissues;
with cholangitis or cholecystitis;
for gynecological infections.
when bacteria damage the teeth and tissues around them;

When is Amoxiclav 875 mg prescribed?

What the prescription of the drug Amoxiclav 2x 875 helps with, the summary of the drug can tell you:

diseases of the organs of hearing and smell - chronic sinusitis, otitis media, pharyngitis;
antibiotic is used to treat severe infections such as chronic pneumonia or bronchitis;
inflammation of the paranasal sinuses;
venereal diseases;
inflammatory disease of the urinary and biliary tract;
infections of bone and joint tissues and skin.

Interesting! Now even in gynecology they can prescribe Amoxiclav tablets to adults.

There are also contraindications for use, such as diseases of the stomach and duodenum and diseases associated with impaired renal function in patients.

Important! Amoxiclav 875 is not prescribed to a child due to the high dosage of amoxicillin.

Side effects

Some young patients react to the suspension with decreased appetite, nausea, abdominal pain, episodes of vomiting, or loose stools. The drug can also affect the functioning of the liver, which will appear in a biochemical blood test (enzyme activity may increase) or provoke jaundice. In some cases, the use of Amoxiclav leads to the appearance of candidiasis.

In addition, treatment with Amoxiclav sometimes causes skin itching, redness, Quincke's edema, urticaria and other allergic reactions. In rare cases, the drug worsens hematopoiesis, and then the number of platelets and leukocytes in the child’s blood test decreases. Occasionally, the consequence of taking the suspension is negative symptoms from the central nervous system (convulsions, sleep disturbances, headaches) or kidney damage.

Pharmacokinetics

After taking the Amoxiclav 375 mg tablet, the active substances are quickly absorbed from the gastrointestinal tract. The drug is absorbed regardless of food intake.

The active substances of Amoxiclav 250 mg + 125 mg are found in tissues and body fluids: gall bladder, abdominal organs, skin, adipose, muscle tissue, synovial, peritoneal fluids, bile, purulent discharge. In the absence of inflammation of the meninges, the active substances do not cross the blood-brain barrier.

Amoxicillin is excreted by the kidneys, and clavulanic acid is also excreted by extrarenal mechanisms. 6 hours after taking Amoxiclav 250 mg + 125 mg, 60-70% of amoxicillin, 40-65% of clavulanic acid are excreted through the kidneys

The active substances cross the placental barrier, trace concentrations are excreted in breast milk.

Instructions for use

Preparation of a suspension from the powder form of the drug is carried out immediately before the start of therapy. To properly dilute the drug, the powder is shaken, after which water is added inside the bottle - up to the mark marked on the bottle or in the amount indicated in the annotation. You need to add the liquid in several stages: first pour a little water and shake vigorously, then add the rest of the water and shake again, waiting until all the powder has dissolved.

To reduce the risk of negative effects of Amoxiclav, it is recommended to drink the drug with meals. The medicine is taken with a plastic syringe, which is sold along with a bottle of powder. The required dose of antibiotic must be determined by the doctor. In this case, to calculate the daily dosage, only the content of amoxicillin in the suspension is taken into account. Babies in the first three months of life are given this substance at 30 mg per kilogram of weight, and at the age of over 3 months - 20 mg/kg.

The indicated daily doses are prescribed if the severity of the disease is moderate or mild. If the infection is severe, then the baby’s weight in kilograms is multiplied by 40 mg of amoxicillin. The same increased dosage is prescribed for damage to the respiratory tract. The calculated amount of the drug with a dosage of amoxicillin of 125 and 250 mg is divided into three doses and given to the child with an interval of 8 hours. For children under three months of age, the daily dose should be divided into two doses and given every 12 hours.

For example, Amoxiclav was prescribed to a 2-month-old baby with a moderate infection who weighs 5000 g. Multiplying 5 by 30, we get 150 mg - this is the dose of amoxicillin that should be given to this patient per day. This amount of antibiotic is contained in 6 ml of suspension with a dosage of 125 mg + 31.25 mg, which means that the baby should be given 3 ml of the medicine twice a day.

If the drug is prescribed for pneumonia in a child whose weight is 15 kg, then he needs 600 mg of amoxicillin (15x40) per day. According to calculations, it turns out that at one time such a patient is given 200 mg of antibiotic, which is contained in 4 ml of suspension with a dosage of 250 mg + 62.5 mg. Approximate dosages depending on the severity of the infection, body weight and age of the baby can also be seen in the table in the paper instructions for the powder.

For a suspension containing 400 mg of antibiotic per 5 ml, the doses are slightly different, but are also indicated on the tablet. The daily amount of such a drug is also calculated using amoxicillin, multiplying the patient’s weight in kilograms by 25-45 mg, depending on the severity of the infectious process. The drug is given twice a day, that is, the calculated daily dose is divided into two doses and approximately the same interval of 12 hours is placed between them.

As for the duration of treatment with Amoxiclav, it differs for different diseases and can be either 5 days or 2 weeks. It is necessary to check with the doctor for how long to give the suspension to the child in order to prevent the development of bacterial resistance and not to leave the infection untreated.

Release forms: suspension and tablets

The pharmacological industry offers the consumer two forms of antibacterial drug release. The first is tablets. It is more suitable for adults. The great advantage of this form is that the tablets are convenient to take anywhere, following the dosage regimen. They are available in dosages of 250 and 500 mg of amoxicillin and 125 mg of clavulanic acid. The blister contains 15 or 20 tablets.

The second form of release is powder from which a suspension is prepared. It is better for children to purchase Amoxiclav in this form, especially for those who do not yet know how to chew or swallow tablets.

The table below shows the dosages in which Amoxiclav powder is produced for children:

Total dose in 5 ml suspension, mg	Amoxicillin dose, mg	Dose of clavulanic acid, mg
125	125	31,25
250	250	62,5
400	400	57

The powder and prepared suspension are white or yellowish-white in color. The product is available in 100 ml dark glass containers. The bottle contains 25 grams of powder. The package is equipped with a measuring spoon or pipette. You can read how to prepare the suspension in the attached instructions and watch the video accompanying the article with a step-by-step algorithm of actions.

Storage conditions and overdose

If the therapeutic dose of the medication is exceeded, disruptions in the functioning of the gastrointestinal tract may occur. The patient may experience stomach pain, vomiting, nausea and diarrhea. Due to disruptions in the nervous system, muscle contractions, lethargy and headaches appear.

An overdose of the drug can lead to hemolytic anemia, renal or liver failure. If the patient shows signs of overdose, stop taking the product. In this case, you will need to consult a specialist. The medication is available only by prescription. The shelf life of Amoxiclav is 2 years. The medication is stored in a dark place that is difficult for children to reach.

Contraindications to the use of antibiotics

Since Amoxiclav is a penicillin antibacterial drug, it is not prescribed to a child who is allergic to penicillin. It should not be given to children who are hypersensitive to cephalosporins and beta-lactam antibiotics.

Other factors limiting the use of the drug include:

individual intolerance to the components of the drug, both primary and auxiliary;
liver failure and problems with liver function;
cholestatic jaundice, which can be provoked by taking an antibacterial agent;
lymphocytic leukemia;
mononucleosis of infectious origin;
renal failure;
colitis;
pathological processes affecting the gastrointestinal tract.

Instructions for use Amoxiclav

The instructions for use indicate that Amcosiclav tablets are for adults and children over 12 years of age (or with a body weight >40 kg)

for
mild or moderate infection,
1 tablet is prescribed.
(250 mg+125 mg) every 8 hours or 1 tablet. (500 mg + 125 mg) every 12 hours, in case of severe infection and respiratory tract infections
- 1 tablet. (500 mg+125 mg) every 8 hours or 1 tablet. (875 mg+125 mg) every 12 hours.

For odontogenic infections

1 tablet is prescribed. (250 mg+125 mg) every 8 hours or 1 tablet. (500 mg + 125 mg) every 12 hours for 5 days.

For moderate renal failure (creatinine clearance 10-30 ml/min), 1 tablet is prescribed. (500 mg + 125 mg) every 12 hours, for severe renal failure (CR

What complications may arise

Like any drug of the penicillin group, Amoxiclav 2x 875 may have side effects, some of which can cause a lot of inconvenience to patients:

if you are sensitive to penicillins, cross-allergic reactions are possible;
severe disturbances in the functioning of bile-forming and hematopoietic organs;
headaches and migraines;
nausea, vomiting, diarrhea;
thrush and itching in the genital area.

In the case of a severe course of the disease, in which the patient is prescribed to take large dosages of Amoxiclav 875, it is worth understanding that the likelihood of consequences is very high.

In order to reduce the risk of impact on the body, the patient should take the drug according to the rules described above, including remembering to take the medication not with meals, but before meals. Also, do not forget to drink plenty of fluids during the course of treatment.

After completion of treatment, the patient should undergo all tests and be examined by a specialist. This will help determine whether there are any undesirable effects from taking an antibiotic and promptly deal with their manifestations.

If, as a result of sanitizing the infection, the number of bacteria has not decreased, and even moreover, they turned out to be resistant to the therapy, you need to turn your attention to other antibiotics, because the composition of each drug is different from each other, and you should also not forget about personal intolerance to some elements of the drugs.

Analogs

Instead of Amoxiclav in liquid form, other antibiotics can be used, the composition of which is represented by the same combination of active substances. The following analogues are produced in suspension:

«»;
«»;
"Panklav 2X";
"Medoclav";
"Augmentin SR".

All of them are used for the same infections and are a complete replacement for Amoxiclav, because in these liquid medicines clavulanic acid is also added to amoxicillin.

In addition, instead of Amoxiclav, amoxicillin preparations, for example, Hiconcil, “” or “” suspension, can be used. Since these antibiotics do not contain clavulanic acid, the spectrum of influence of such drugs on bacteria is not as wide as that of Amoxiclav, but in some situations they are also suitable for treating sore throat, bronchitis or other infections. But it is up to the doctor to decide whether amoxicillin alone can be used for a particular child.

Another popular option for replacing Amoxiclav with drugs with a similar effect is cephalosporin antibiotics. They are noted to be highly effective, but such medications should also be prescribed by a specialist, because they have their limitations.

In childhood, among the cephalosporins, the most popular are "", "", "" and "", since they have a convenient release form - granules or powder. But, if the infection is severe, the doctor may prescribe injectable medications, for example, "" or "".

If you are allergic to amoxicillin and other penicillin or cephalosporin antibiotics, the doctor will select a drug from another group, for example, a macrolide drug. For example, it could be a “suspension” approved for children of any age. Also often used in childhood are suspensions “” and “”, which can be given to children older than 6 months.

For detailed information about the antibiotic "Amoxiclav" for children, see the following video.

Names of antibiotics for colds and flu

In the treatment of respiratory diseases, targeted drugs are used that act on the cause of the disease. They inhibit pathogens. This type of therapy is called etiological therapy. In the fight against flu and colds, the main thing is to choose the right medications. Some people, in an effort to recover as quickly as possible, start taking strong antibiotics for colds at the first symptoms of ARVI. Is it correct?

When to take antibiotics for colds and flu

In most cases, respiratory diseases are caused by viruses, which are not affected by antibacterial medications. Therefore, their use from the first day of the disease is not justified. Treatment of respiratory diseases with antibiotics is justified if, on the 5th-6th day of the flu or cold, a person feels consistently unwell. As a rule, these are symptoms of a bacterial infection, which provokes the development of purulent sore throat, acute bronchitis, and pneumonia.

Signs of complications of flu and colds:

after the onset of ARVI, following improvement on days 5-6, body temperature rises sharply;
general health worsens, fever, cough, shortness of breath appear;
pain in the throat, chest area, and ears intensifies;
lymph nodes enlarge.

When treating colds and flu with antibiotics, never interrupt treatment when you feel better. People who make this mistake suffer twice as much later. In this case, an improvement in a person’s condition does not mean that the disease has passed. A batch of bacteria died under the influence of antibiotics, but another part of them adapts to the drug and begins to attack the weakened body with renewed vigor. This leads to a new round of the disease with subsequent complications.

What antibiotics are best to take for a cold?

To treat respiratory diseases, bactericidal drugs are taken to destroy pathogenic microorganisms. Antibiotics play the role of heavy artillery in the fight against colds and flu when there is a risk of acute complications. Three main groups of antibacterial drugs are used to treat respiratory diseases:

penicillin - ampiox, augmentin, amoxapclav;
cephalosporins - cefotaxime, cefpirome, cefazolin;
macrolides - roxithromycin, azithromycin, clarithromycin.

List of effective antibiotics for adults

For colds of bacterial origin, doctors prescribe antibiotics in extreme cases. A prolonged cough, persistent sore throat, severe fever, and persistently high body temperature are alarming signs of the development of an acute disease. In this case, traditional antiviral drugs, immunostimulants, vitamins and herbs are powerless. For effective therapy, you need to know which antibiotic is best for a cold in an adult:

amoxicillin;
arlet;
flemoclav;
rovamycin;
azithromycin;
hemomycin;
suprax;
cefepime;
erythromycin;
Levofloxacin.

Names of good drugs for children

For the treatment of bacterial diseases at an early age, antibiotics are used in extreme cases. For pneumonia, acute otitis media, purulent sore throat resulting from a respiratory illness, taking such drugs is justified. The form of antibiotics prescribed depends on the age of the child. For infants - medicines in injections, for older children - in tablets. Babies are not always given injections; you are allowed to open the ampoule and give the child the medicine in the required dosage. Children's antibiotics for colds:

ampicillin;
flemoxin solutab;
Moximac;
avelox;
augmentin;
zinnat;
macrofoam;
fromilid uno;
esparoxy;
alpha normix.

Parents often mistakenly believe that antibacterial therapy is necessary for the successful treatment of flu and colds in children. This is a misconception about the effect of antibiotics on a child's body. For viral infections in children, the use of these drugs is unjustified, even at high temperatures that persist for a long time.

Treatment of children with antibiotics leads to dysbiosis, weakened immune system, and anemia. It is advisable to administer antibacterial therapy to children only in critical situations. For example, when aerobic streptococcal tonsillitis, acute otitis media, pneumonia, inflammation of the paranasal sinuses are observed. The use of antibiotics for the treatment of children with colds and flu without complications is justified when:

pronounced signs of reduced body resistance - constant subfertile body temperature, frequent colds and viral diseases, HIV, oncology, congenital disorders of the immune system;
rickets, malformations of general development, lack of weight;
the child has a history of chronic recurrent otitis media.

Gentle drugs for the treatment of colds in pregnant women

When treating complications of a respiratory disease in an pregnant woman or a nursing mother, the effect of the antibiotic on the development of the fetus is taken into account. For treatment, gentle antibacterial drugs are selected. To select the appropriate medicine, the doctor identifies the causative agent of the disease and its resistance to various drugs. If it is impossible to conduct such a study, gentle antibiotics for pregnant women are prescribed:

ampicillin;
oxacillin;
cefazolin;
erythromycin;
azithromycin;
bioparox;
minocycline;
oxamp;
ericcycline;
ristomycin.

For the treatment of flu and colds in pregnant and nursing mothers, in order to avoid the occurrence of dysbacteriosis, it is advisable to take drugs in the form of injections. To avoid allergic reactions, the use of antibacterial therapy is combined with antihistamines. Chocolate, citrus fruits, and coffee are excluded from the diet of pregnant and lactating women.

List of broad-spectrum antibiotics

In bacterial therapy for the treatment of complications of influenza and colds, drugs are prescribed aimed at suppressing groups of pathogens. Such drugs are called broad-spectrum antibiotics. They help cure complications of influenza and acute respiratory infections. Cheap pills are as effective as expensive ones. These types of medications are available in pharmacies without a prescription. Before taking, read the instructions and read reviews about antibiotics. A good drug has few side effects. Broad-spectrum antibiotics:

amosin;
becampicillin;
ospamox;
ecoball;
zinforo;
kefselim;
flamefix;
cefodox;
clacid;
oletherine

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Pharmacological effect

The combination of amoxicillin with clavulanic acid is unique in its own way. Amoxicillin and other penicillin antibiotics cause the death of bacterial cells by binding to their surface receptors. However, during the use of the drug, most bacteria have learned to destroy this antibiotic using the enzyme beta-lactamase.

Gram-negative bacteria are also sensitive to amoxiclav:

bordetella;
Brucella;
gardnerella;
Klebsiella;
Moraxella;
salmonella;
Proteus;
shigella;
clostridium and others.

Regardless of the combination with food, the drug is well absorbed into the body, the maximum concentration of the drug is achieved within the first hour after administration.

Description of the drug

Before considering whether Amoxiclav can be taken for the flu, it is important to understand what effect this drug has. At the same time, it must immediately be said that this antibiotic can only be effective against those microorganisms that are sensitive to it. It will not have a suppressive effect on all other bacteria, which means it will not eliminate the source of the disease.

That is why, before initially prescribing Amoxiclav for flu and colds, it is very important to test the sensitivity of bacteria to its active substance.

Many people wonder whether Amoxiclav helps with the flu, because, as most patients mistakenly think, it is antibiotics that can most quickly eliminate a cold. In fact, this opinion is deeply erroneous, because the flu is always provoked by a virus, which means that in order to cure it, a person should take antiviral medications.

As for Amoxiclav, it is an antibiotic that has a completely different therapeutic direction. With its help, you can only eliminate bacterial complications, which sometimes develop against the background of a cold.

Thus, Amoxiclav for influenza will be useful only when aerobic and anaerobic bacteria of different classes actively multiply in a person during this pathology.

Amoxiclav prevents bacterial growth

Pharmacological properties and indications for use

Amoxicillin is an antibiotic that is considered a semi-synthetic derivative of penicillin. Functional against a huge number of bacteria, has a bactericidal effect. The main active components of the drug are absorbed from the intestines. When the level of components in the blood reaches the required concentration, the fight against the disease begins after 3 hours. The elements of Amoxiclav are perfectly distributed throughout all tissues of the body.

Clavulanic acid and amoxicillin pass through the fetal placenta during pregnancy and are passed on to the baby through breastfeeding. The active elements are excreted unchanged by the kidneys. The half-life is 65 minutes. Amoxiclav 500 is indicated for viral diseases that are caused by sensitivity to penicillin:

Infectious diseases of the urinary system.
Infectious flows in the cells of the abdominal cavity.
Infectious disorders of the upper respiratory tract.
Infectious skin diseases.

The medication has contraindications for use. For example:

Viral diseases.
Severe disorders of the multifunctional activity of the kidneys and liver.
Tumor process.
Allergy to penicillin.

The medicine is taken orally after meals. The dosage is prescribed only by a doctor; it depends on the age and weight of the patient. Recommended standards:

Schoolchildren over 12 years of age and adult patients take one 500 mg tablet 2 times a day.
In severe cases of the disease, tablets are used 2 times a day.
Children aged 6 to 12 years should take half a tablet 2 times a day.

Antibiotics for colds and flu: what is best for adults to take

People with medical education know for certain that antibiotics for colds and flu are ineffective, but they are not cheap and are harmful.

Moreover, both doctors in clinics and those who have just graduated from medical school know this.

However, antibiotics are prescribed for colds, and some patients are advised to take these medications to prevent infections.

For a common cold, it is better to do without antibiotics. The patient must be provided with:

bed rest;
drinking plenty of water;
balanced diet with a high content of vitamins and minerals;
if necessary, effective antipyretic tablets or injections;
gargling;
inhalation and nasal rinsing;
rubbing and compresses (only in the absence of fever).

Perhaps the treatment of colds can be limited to these procedures. But some patients persistently ask their doctor for a good antibiotic or a cheaper analogue.

It happens even worse: a sick person, due to the fact that he has no time to visit the clinic, begins self-medication. Fortunately, pharmacies in big cities today are located every 200 meters. There is no such open access to medicines as in Russia in any civilized state.

But in fairness, it should be noted that many pharmacies have begun to dispense broad-spectrum antibiotics only with a doctor’s prescription. However, if you wish, you can always pity the pharmacy pharmacist by citing severe illness or find a pharmacy for which turnover is much more important than people’s health.

Therefore, antibiotics for colds can be purchased without a prescription.

When should you take antibiotics for acute respiratory infections and flu?

In most cases, colds are of viral etiology, and viral infections are not treated with antibiotics. Broad-spectrum tablets and injections are prescribed only in cases where an infection has arisen in an organism weakened by a cold that cannot be defeated without antibacterial drugs. This infection can develop:

in the nasal cavity;
in the mouth;
in the bronchi and trachea;
in the lungs.

In such a situation, antibiotics are needed for colds and flu.

Laboratory research methods, the results of which can be used to judge the need to take antibacterial agents, are not always prescribed. Often, clinics save on sputum and urine cultures, explaining their policy by saying that this is too expensive.

Exceptions are smears taken from the nose and pharynx for sore throat for Lefler's bacillus (the causative agent of diphtheria), selective cultures of urine for diseases of the urinary tract and selective cultures of tonsil discharge, which are taken for chronic tonsillitis.

Patients treated in a hospital are much more likely to have laboratory confirmation of a microbial infection. Changes in clinical blood test are indirect signs of bacterial inflammation. Having received the results of the analysis, the doctor can proceed from the following indicators:

ESR;
leukocyte count;
an increase in segmented and band leukocytes (shift of the leukocyte formula to the left).

And yet, doctors prescribe antibiotics for colds very often. Here is a clear example of this, taken from the results of an inspection of one children's medical institution. 420 outpatient records of young patients from 1 to 3 years were analyzed. In 80% of cases, doctors diagnosed children with acute respiratory infections, acute respiratory viral infections; acute bronchitis – 16%; otitis – 3%; pneumonia and other infections – 1%.

For pneumonia and bronchitis, antibacterial therapy was prescribed in 100% of cases, but in 80% it was prescribed for both acute respiratory infections and inflammation of the upper respiratory tract.

And this is despite the fact that the vast majority of doctors are well aware that using antibiotics without infectious complications is unacceptable.

Why do doctors still prescribe antibiotics for flu and colds? This happens for a number of reasons:

reinsurance due to the early age of children;
administrative settings;
preventive measures to reduce complications;
lack of desire to visit assets.

How to determine complications without tests?

A doctor can determine by eye that an infection has been added to a cold:

the color of discharge from the nose, ears, eyes, bronchi and pharynx changes from transparent to dull yellow or poisonous green;
when a bacterial infection occurs, a repeated rise in temperature is usually observed, this is typical for pneumonia;
the patient's urine becomes cloudy and sediment can be observed in it;
pus, mucus or blood appears in the stool.

Complications that may arise after ARVI are determined by the signs given below.

The situation is this: a person had an acute respiratory viral infection or a cold and was already on the mend, when suddenly the temperature jumped sharply to 39, the cough intensified, chest pain and shortness of breath appeared - all these manifestations signal that there is a high probability of developing pneumonia.
If a sore throat or diphtheria is suspected, the temperature rises, the sore throat intensifies, plaque appears on the tonsils, and the lymph nodes on the neck become enlarged.
With otitis media, fluid is released from the ear, and when you press on the tragus in the ear, severe pain appears.
Signs of sinusitis manifest themselves as follows: the patient’s sense of smell completely disappears; Severe pain occurs in the forehead area, which intensifies when the head is tilted; the voice becomes nasal.

What antibiotics to take for a cold?

Many patients ask their therapists this question. Antibiotics for colds should be chosen based on the following factors:

localization of infection;
the age of the patient (adults and children have their own list of medications);
medical history;
individual drug tolerance;
state of the immune system.

But in any situation, only a doctor prescribes antibiotics for colds.
Sometimes broad-spectrum antibiotics are recommended for use against uncomplicated acute respiratory infections.

Against some blood diseases: aplastic anemia, agranulocytosis.

With clear signs of weakened immunity:

low-grade fever;
colds and viral diseases more than five times a year;
chronic inflammatory and fungal infections;
HIV;
congenital pathologies of the immune system;
oncological diseases.

Children under 6 months:

against infant rickets;
against weight loss;
against various developmental defects.

It is recommended to take antibiotics for colds for the following indications:

Bacterial tonsillitis requires treatment with macrolides or penicillins.
Purulent lymphadenitis is treated with broad-spectrum drugs.
Acute bronchitis, exacerbation of its chronic form, and laryngotracheitis and bronchiectasis will require the prescription of macrolides. But first it is better to do a chest x-ray, which will rule out pneumonia.
In acute otitis media, after otoscopy, the doctor makes a choice between cephalosporins and macrolides.

Azithromycin – an antibiotic for colds and flu

Azithromycin (other name Azimed) is a broad-spectrum antibacterial drug.
The active substance of the drug is directed against the protein synthesis of sensitive microorganisms. Azithromycin is rapidly absorbed from the gastrointestinal tract. The peak effect of the drug occurs two to three hours after administration. Azithromycin is rapidly distributed in biological fluids and tissues. Before you start taking pills, it is better to test the sensitivity of the microflora that provoked the disease. For adults, Azithromycin should be taken once during the day, one hour before meals or three hours after meals.

For infections of the respiratory tract, skin and soft tissues, a single dose of 500 mg is prescribed on the first day of admission, then for three days the patient takes Azithromycin 250 mg per day.
For acute urinary tract infections, the patient should take three Azithromycin tablets once.
Against the initial stage of Lyme disease, three tablets are also prescribed once.
For stomach infections caused by Helicobacter pylori, the patient should take three to four tablets at a time for three days.

The release form of the drug is tablets (capsules) of 6 pieces in a package (blister).

Other antibacterial drugs

If the patient does not have an allergic reaction to penicillin, antibiotics for influenza can be prescribed from the semi-synthetic penicillin series (Amoxicillin, Solutab, Flemoxin). In the presence of severe resistant infections, doctors prefer “protected penicillins,” that is, those consisting of Amoxicillin and Clavulanic acid, here is their list:

Solutab.
Flemoclav.
Augmentin.
Ecoclave.
Amoxiclav.

For angina, this treatment is best.

Names of cephalosporin drugs:

Cefixime.
Ixim Lupin.
Pantsef.
Suprax.
Zinatsef.
Cefuroxime axetil.
Zinnat.
Aksetin.
Super.

For mycoplasma, chlamydial pneumonia or infectious diseases of the ENT organs, the following medications are prescribed:

Azithromycin.
Macropen.
Azitrox.
Z factor.
Chemomycin.
Zitrolide.
Zetamax.
Sumamed.

Should antibiotics be prescribed?
It is useless to treat influenza and ARVI with them, so this problem falls entirely on the shoulders of the doctor. Only a physician who has the patient’s medical history and test results in front of him can give a full account of the advisability of prescribing a particular antibacterial drug. In addition, inexpensive but effective antiviral drugs can be used in treatment, which indicates an integrated approach to the treatment of influenza.

The problem is that most pharmaceutical companies, in pursuit of profit, continually throw out more and more new antibacterial agents into a wide sales network. But most of these drugs could be in stock for the time being.

Antibiotics, flu, colds - what conclusions can be drawn?

So, from all that has been said above, we can conclude that antibiotics should be prescribed only for bacterial infections. Flu and colds are 90% viral in origin, so for these diseases, taking antibacterial drugs will not only not bring benefit, but can provoke a number of side effects, for example:

decreased immune response of the body;
depression of kidney and liver function;
imbalance of intestinal microflora;
allergic reactions.

The use of these drugs for the prevention of viral and bacterial infections is unacceptable. Taking aggressive medications, such as antibiotics, is possible only in extreme cases, when all indications exist.

The main criteria for the effectiveness of treatment with antibacterial drugs include the following changes:

relief of the patient’s general condition;
decrease in body temperature;
disappearance of symptoms of the disease.

If this does not happen, then the medicine needs to be replaced with another. To determine the effectiveness of the drug, three days must pass from the start of treatment. Uncontrolled use of antibacterial medications leads to disruption of the resistance of microorganisms.

In other words, the human body begins to get used to antibiotics and each time require more and more aggressive drugs. In this case, the patient will have to be prescribed not one drug, but two or even three.

Everything you need to know about antibiotics is in the video in this article.

stopgripp.ru⁪>

Compound

The action of Amoxiclav is provided by two active ingredients at once. The first of these is amoxicillin, presented in this medication in the form of a trihydrate. Its dosage in 5 milliliters of an already prepared suspension can be 125 mg or 250 mg, as well as 400 mg. The second component is the potassium salt of clavulanic acid. Its dosage in 5 milliliters of medication is 31.25 mg, 62.5 mg or 57 mg.

Among the auxiliary ingredients of the medicine you can see silicon dioxide, carmellose sodium, sodium citrate, citric acid and some other compounds, thanks to which the powder is stored for a long time and easily dissolves. To make the product taste sweet and smell good, lemon, strawberry and wild cherry flavors are added to it, as well as sodium saccharinate.

Price for Amoxiclav 875 mg in different cities of Russia

The price of Amoxiclav 2x tablets 875 mg by 125 mg is in the range from 395 to 420 rubles per pack. But the price for Kviktab will be from 400 to 470.

Prices for many analogues of Amoxiclav 875 may be lower, but before purchasing cheaper substitutes, you should weigh the pros and cons, carefully study the instructions of the drugs and consult a doctor.

Currently, pharmacological networks have a very large selection of drugs aimed at combating various infections. However, without having the skills of a pharmacist, you should not make hasty conclusions about the quality of a product based on its price. Nowadays, consumers often buy drugs that they later regret taking.

Injection

The use of Amoxiclav in the form of an injection solution intended for intravenous administration is widely used.

If a child under three months of age is to be treated, the injection solution is administered very slowly over 40 minutes. The dose of the drug is calculated depending on the weight of the baby:

The presented treatment regimen and calculation of the substance remain the same in general for children from 3 months to 12 years: the dosage is calculated according to the same proportions: 30 mg/kg. body weight, the time of administration of the drug is also maintained (three times a day), however, at this age, in case of severe infections, the intervals between injections can be reduced to 6 hours.

We list the main dosages of the drug for children whose body weight does not exceed 40 kg:

Creatinine clearance: 10–30 ml/min.: Amoxiclav is used at 25 mg/5 mg. per 1 kg. body weight every 12 hours;
Creatinine clearance: less than 10 ml/min: 25 mg/5 mg. per 1 kg. body weight every 24 hours;
Hemodialysis: 25 mg/5 mg. per 1 kg. body weight every other day using an additional dose of 12.5 mg/2.5 mg. per 1 kg. body weight at the end of dialysis.

For adult patients and children over 12 years of age with a body weight of more than 40 kg, Amoxiclav is administered at a dose of 1200 mg. every 8 hours, and in acute infectious diseases - every 6 hours.

If patients suffer from renal failure, Amoxiclav doses are adjusted: the dose is reduced or the intervals between doses of the drug are increased:

Since during hemodialysis about 85% of the drug leaves the body, at the end of each session the patient is administered the usual dose of the injection solution. No dosage adjustment is required for peritoneal dialysis.

The exact duration of treatment, which usually ranges from a week to two weeks, can only be determined by the attending physician. If the patient experiences a decrease in the severity of symptoms during treatment, then you can switch from injections to oral forms of Amoxiclav.

In order to prepare a solution for injection, the entire contents of the bottle (600 mg) are dissolved in 10 ml. water for injection, respectively 1200 mg. – in 20 ml. water for injections.

Intravenous administration of the drug must be done no later than 20 minutes after preparing the solution. The drug should be administered very slowly, over about 3-4 minutes.

Intravenous infusions are made with Amoxiclav solution. For this, ready-made solutions that contain 1200 mg. or 600 mg. the drug must be diluted again in 50 or 100 ml. solution for infusion. The duration of the infusion is 30 to 40 minutes.

The indicated dosages of substances and liquids for dilution allow you to maintain the required concentration of amoxicillin in the infusion solution.

We indicate periods of stability of the concentration of the active substance in solutions:

Aqueous solution: 4 hours at 25 °C and 8 hours at 5 °C;
Solutions of sodium chloride and calcium chloride intended for intravenous infusion: 3 hours at 25 °C;
Ringeralactate solution for intravenous infusion: 3 hours at 25 °C;
Sodium chloride solution 0.9% for intravenous infusion: 4 hours at 25 °C and 8 hours at 5 °C.

The prepared solution must not be frozen. Do not mix Amoxiclav solution with solutions of dextran, sodium bicarbonate or dextrose. Only clear solutions can be administered intravenously.

How to use

The exact dosage regimen is inserted by the doctor individually, depending on the severity of the disease and the healing effect. The duration of treatment with an antibiotic can be from 5 to 14 days.

Pills

Take orally just before eating, swallowing whole, without chewing and washing down with water.

As noted in the instructions, adults and children weighing more than 40 kilograms with pathologies of mild and moderate severity are prescribed 1 tablet (250 milligrams/125 milligrams) every 8 hours (3 times throughout the day) or 1 tablet (500/125 milligrams) ) every 12 hours (2 times throughout the day); in severe forms of the disease, 1 tablet of 500 milligrams/125 milligrams is prescribed every 8 hours (three times throughout the day) or 1 tablet of 875 milligrams/125 milligrams every 12 hours (twice throughout the day).

Amoxiclav Quiktab tablets

Before use, the tablet must be dissolved in 100-150 milliliters of water and stirred very well. Adults and children over 12 years of age are prescribed 1 tablet (500 milligrams/125 milligrams) 2-3 times a day; for severe conditions - 1 tablet (875 milligrams/125 milligrams) twice a day.

Powder for parenteral use

To prepare a solution for intravenous administration, dissolve the contents of the bottle in water for injection (for Amoxiclav 600 milligrams - 10 milliliters; for Amoxiclav 1.2 grams - 20 milliliters). Then the resulting solution is administered intravenously slowly over 4-5 minutes.

If the medicine must be administered as an intravenous infusion, then 600 milligrams of the medicine are diluted in 10 milliliters of water for injection and added to the infusion solution (50 milliliters). Antibiotic 1.2 grams is diluted in 20 milliliters of water for injection and added to 100 milliliters of infusion solution. The drug is administered dropwise over 30-40 minutes. Freezing of funds is not permitted.

Suspension

Shake the bottle with the powder very well, add warm boiled water (up to the mark) in 2 additions, shaking each time until the powder is completely dissolved.

In pediatrics, newborns and infants up to 3 months are prescribed a medicine at the rate of 30 milligrams per 1 kilogram of weight (daily dose), this amount must be divided and given in 2 doses at equal, irregular intervals.

From 3 months, the antibiotic is prescribed at a dose of 25 milligrams per 1 kilogram of body weight, which is also divided equally into 2 doses. For infectious diseases of moderate severity, 20 milligrams per 1 kilogram of body weight are prescribed and divided into 3 administrations. In severe conditions, the dose is greater - 45 milligrams per 1 kilogram of weight and divided into 2 injections throughout the day.

additional information

Amoxiclav must be stored in a dry place at a temperature not exceeding 25 °C and out of the reach of children. The shelf life of the drug expires after three years from the date of release. The drug is packaged in a cardboard box containing 5 or 7 blisters. One blister contains two dispersible tablets. Amoxiclav is available with a doctor's prescription.

Manufactured by Personale 47, 2391 Prevalje, Slovenia (full cycle). Verovškova 57, Ljubljana 1526, Slovenia (series release); Lek, enterprise comp. Sandoz, Poland/Slovenia.

Sources

https://www.sandoz.ru/news/media-releases/the-company-sandoz-represents-a-novelty-in-the-children-line-amoxiklav-quicktab
https://studfiles.net/preview/5243279/page:4/
https://fb.ru/article/408242/amoksiklav-proizvoditel-instruktsiya-po-primeneniyu-analogi
https://www.rlsnet.ru/tn_index_id_219.htm#proizvoditel%60
https://farmamir.ru/2015/07/amoksiklav-instrukciya-primenenie-otzyvy/
https://sportwiki.to/Distribution_of_medicines
https://infekc.ru/infekcionnue/odontogennye-infekcii-simptomy-i-lechenie.html

Alla Kanchar, Pharmacy, pharmacist 4 articles on the site

Graduated from Lugansk State Medical University. She defended her thesis on the topic: “Prospects for the development of an ophthalmic dosage form based on a phytochemical substance obtained from the herb Canadian petal.” I work as a pharmacist in a pharmacy in Lugansk.

Comparison of Amoxiclav Quiktab and Amoxiclav

After studying the instructions for the drug Amoxiclav 500/125, many patients remain perplexed as to how Amoxiclav Quiktab differs from Amoxiclav, if the content of active substances (amoxicillin and clavulanic acid) is completely identical.

The secret lies in the dispersible tablets. The name comes from the word dispersion - mixing, dissolution, which occurs in the oral cavity. The drug is absorbed by the walls of the duodenum, which allows for a faster and more effective effect on pathogenic microorganisms.

What does Amoxiclav help with?

Indications for use include infectious and inflammatory diseases that develop due to the influence of microorganisms sensitive to this medicine. The following indications for the use of Amoxiclav are determined:

biliary tract infections (cholangitis, cholecystitis);
odontogenic infections;
connective and bone tissue infections;
infectious diseases of soft tissues, skin (including consequences of bites);
infectious diseases of the lower respiratory tract (pneumonia, acute and chronic bronchitis);
gynecological diseases of an infectious nature;
urinary tract infections (cystitis, prostatitis, etc.);
infections of the ENT organs, as well as infectious diseases of the upper respiratory tract (otitis media, retropharyngeal abscess, sinusitis, pharyngitis, tonsillitis).

About the side effects of antibiotics

Any drug, regardless of manufacturer, composition, or high cost, can lead to undesirable consequences. Amoxiclav is no exception.

Taking the drug may cause nausea, loss of appetite, vomiting, diarrhea and/or abdominal pain. Among the adverse reactions, the manufacturer lists allergic rash, itching, urticaria, headaches, and dizziness. The package insert for the drug states that rare cases of liver dysfunction, anaphylactic shock, reversible leukopenia, seizures, etc. have been recorded.

Adult patients and parents of young patients should not be afraid of the large list of side effects of Amoxiclav. This only means that the drug has been carefully studied by the manufacturer.

It is worth paying attention to the fact that the drug can cause poisoning or increase side effects if you neglect the dosages recommended by the manufacturer. When should you call emergency services or see a doctor yourself? Symptoms of an overdose of Amoxiclav:

Symptoms of an overdose of Amoxiclav:

dysfunctions of the gastrointestinal tract, leading to a significant deterioration in overall health;
anxiety, insomnia, dizziness and even convulsions.

The problem can be solved by adjusting the dosage and/or treating the above symptoms. If you have recently taken the drug, gastric lavage and activated charcoal are recommended. You can also remove Amoxiclav from the body by hemodialysis using an artificial kidney machine.

Reviews

Doctors in reviews report that this medication is more effective in treating various diseases of the respiratory canals than its analogues. Typically, specialists prescribe a course of five days, after which it is necessary to take drugs that restore the microflora. Doctors report that this drug has an excellent effect on bacterial infections of the genital tract, rarely causing side effects.

Also in reviews of Amoxiclav 875+125 it is reported that in parallel, doctors prescribe antifungal medications with probiotics to restore normal microflora. Injection use of the drug allows you to quickly eliminate the manifestations of diseases of the otolaryngological organs. The comments also note that the medication in question treats inflammation of the middle ear well.

Is Amoxiclav 875+125 effective for sinusitis?

Use for cystitis

According to the instructions, for cystitis the drug is taken as follows:

The pills must be dissolved in 250 milliliters of water, mixed thoroughly and taken according to the scheme.
Before use, the powder must be diluted in one glass of water.
Take tablets, as a rule, half an hour before meals to reduce the risk of side effects.
The drug is used for adults and children over twelve years of age, provided their weight is over forty kilograms. The maximum daily dosage is 1200 milligrams. You should take one tablet every twelve hours.
In the presence of severe disease, it is allowed to increase the dose to 1000 milligrams at a time. The maximum daily dosage is 2 grams. The intervals between doses are eight hours at a dose of 625 milligrams of the drug and 12 hours at 1000.
The course of treatment for cystitis usually lasts seven days. When the course of the disease becomes severe, the course increases to fourteen days.
If the patient has severe kidney failure, the one-time dosage of the drug should not exceed 625 milligrams.

Treatment of cystitis is carried out in outpatient and inpatient settings. The described drug has a number of adverse reactions, therefore, at the time of therapy, monitoring is carried out by a medical professional. Particular attention is paid to the first dose of the drug in order to timely detect allergic reactions. Some patients treated with this drug may experience anaphylactic shock. For example, one patient took Amoxiclav for cystitis, and within three hours of taking the pills she developed anaphylactic shock. Fortunately, the necessary medical measures were provided in a timely manner. Next, we will find out how to take the medication in question if patients develop bronchitis.

Amoxiclav 875+125 is prescribed for bronchitis. Is this justified?

Drug interactions

The absorption of the described drug slows down under the influence of antacids, glucosamines, and laxative dosage forms. A reverse accelerated effect is observed when taking ascorbic acid.

If we talk about NSAIDs, Phenylbutazone, Allopurinol, various diuretics , they lead to blockade of tubular secretion, thereby increasing the amount of amoxicillin. Considering the combination of Probenecid with Amoxiclav, it is clear that the level of the active antibiotic substance is likely to increase. When combined with Methotrexate, the toxic effect of this medication increases significantly. Therefore, such a duet is not recommended to be used in practice.

The antibacterial effect is reduced by Rifampicin . You should not simultaneously be treated with drugs that minimize the work of Amoxiclav. For the same reasons, it is worth abandoning the parallel use of sulfonamides.

Women should remember that the drug described often reduces the effect of oral contraceptives.

special instructions

During treatment there is a risk of superinfection. It is provoked by bacteria that exhibit active resistance to the drug. If it is possible to develop mononucleosis with an infectious genesis , it is worth using another, more suitable medication.

Amoxiclav-based therapy is immediately discontinued if symptoms of antibiotic-associated colitis . If during treatment convulsions and dizziness , for this period it is better to avoid driving or operating complex mechanisms that require increased concentration.

A standard contraindication or special instruction is abstinence from alcohol for the period of the therapeutic course. Combination with antibiotics will worsen the general condition.

Combination with other drugs

If the patient takes ascorbic acid (vitamin C) in parallel with Amoxiclav, this will only improve the absorption of the antibiotic. But some other drugs can slow down this process, in particular:

antacids (Almagel, Phosphalugel, Smecta, etc.);
medications containing glucosamine (Teraflex, Artra);
laxatives (Senadexin, Guttalax, Bisacodyl);
aminoglycosides (Gentamicin, Amikacin).

The attending physician should also take into account that diuretics (Furosemide, Torasemide), Allopurinol, Phenylbutazone, non-steroidal anti-inflammatory drugs (Ibuprofen, Nimesulide) and some other drugs block tubular secretion of the kidneys. This means that their simultaneous use with Amoxiclav increases the concentration of amoxicillin, leading to increased side effects and overdose. By the way, clavulanic acid “does not suffer” from this interaction. It is derived mainly in a different way.

The interaction of other drugs with Amoxiclav has also been studied. You should be careful when prescribing and taking this drug with Methotrexate, Disulfiram, Rifampicin, macrolide and tetracycline antibiotics, and sulfonamides.