Rectal suppositories Ketonal - instructions for use

When is the drug prescribed?

The composition of the ampoules allows for intravenous injections in the presence of the following indications:

1. Rheumatoid arthritis, which affects the small and large joints of the extremities.
2. Osteoarthritis affecting cartilage tissue.
3. Psoriatic and gouty arthritis.
4. Ankylosing spondylitis, which causes limited mobility of the spine. This is due to the fusion of intervertebral joints and the occurrence of inflammation in them.
5. For various pain syndromes - neuralgia, tendonitis, joint pain, ossalgia, bursitis, radiculitis, adnexitis, back pain and toothache.
6. Prescribed as an analgesic during the period of postoperative pain and syndrome that occurs along with inflammation.
7. Injections help cope with pain associated with oncology and tumors.
8. Ketonal injections are prescribed by doctors to women during painful menstruation and during childbirth.

When are suppositories prescribed?

These drugs can be used for various diseases of internal organs, as well as colds. In addition, there are suppositories for adults and for children (they differ in the dosage of the drug). Such a remedy can replace medications produced in tablet form. A rectal suppository has a local effect on the large intestine. These medications are often used to treat conditions in pregnant women and children. A rectal suppository is prescribed for the following conditions:

• fever associated with the presence of inflammatory and infectious pathologies (ARVI, tonsillitis, acute respiratory infections);
• spasms in the digestive system (intestinal, biliary colic, pylorospasm, cholecystitis);
• peptic ulcers of the intestines and stomach;
• severe pain syndrome in children (headache, muscle pain, post-traumatic pain, toothache);
• haemorrhoids;
• spasms of the genitourinary system;
• it is acceptable to use after vaccination if the child has a high temperature;
• algodismenorrhea;
• biliary dyskinesia, which is accompanied by spasms.

It is recommended to use suppositories after bowel movements (you can pre-administer a cleansing enema). For children, a rectal suppository is the best remedy for constipation. In addition, nowadays doctors prescribe rectal suppositories for children as immunomodulatory and antifermentation agents. The pharmacy often asks for anti-inflammatory suppositories, since they relieve pain well. Some anti-inflammatory rectal suppositories add epinephrine. This remedy stops bleeding well.

Analogs

When choosing a drug, you should pay attention to its analogues. This will allow you to choose the most suitable product at the lowest price.

It is worth saying that not all Ketonal analogues have the same pronounced effect, so an alternative should be discussed with a specialist.

Analogues of the drug Ketonal:

• Artrum.
• Artrosilene.
• Bystrumgel.
• Ketoprofen.
• Oruvel.
• Fastum.
• Flexen.

The listed analogues of the product contain the substance ketoprofen, which is found in the drug Ketonal.

Since the medicine has a number of side indications, it is necessary to consider analogues of Ketonal according to the mechanism of action, but containing a different active substance. These drugs include selective NSAIDs; they have fewer adverse reactions:

• Meloxicam.
• Nimesulide.
• Celebrex.
• Etoricoxib.

These drugs are available in a large number of medications. It is worth discussing the possibility of their use with your doctor.

Local treatment

However, rectal suppositories, which are intended for prostatitis, bring less effect than suppositories for abnormalities in the rectum. The reason is the inaccessibility of the prostate gland, so suppositories for prostatitis cannot quickly penetrate the affected area, but only penetrate through nearby tissue. To quickly penetrate the necessary substances to the prostate, suppositories intended for the inflamed gland contain a certain carrier.

Suppositories are prescribed by a urologist both for prevention and for exacerbation. The choice of suppositories depends on what effect a man expects for prostatitis. Usually medications with antibiotics are prescribed to relieve spasms, with propolis and other beneficial ingredients. The suppositories are designed to eliminate swelling, relieve pain and inflammation. They are also able to supply tissues with oxygen and prevent stagnation from forming. Quickly normalize sexual performance and urination.

Suppositories promote rapid recovery of the inflamed prostate

The doctor prescribes suppositories in addition to the main treatment regimen for prostatitis. Therapy usually lasts about two weeks, after which a break is taken for 10 days and the entire prescribed course is repeated again. The exact treatment regimen depends on the individual case.

What does it help with?

The medicine is prescribed for the symptomatic treatment of painful conditions. Indications for use are foci of inflammation of various natures:

• rheumatoid arthritis;
• seronegative spondyloarthropathy;
• gout and pseudogout;
• inflammation of synovial bursae, tendon tissue;
• degenerative pathologies of the musculoskeletal system (including osteoarthritis).

Ketonal injections are also used for pain accompanying the following conditions:

• migraine, headache;
• neuralgia, myalgia;
• oncological diseases;
• menstrual irregularities;
• periods after injuries or operations, accompanied by fever and the development of inflammatory processes.

The doctor may prescribe a drug to relieve symptoms: inflammation, pain. The medicine eliminates the manifestations of the disease, but does not affect its development.

Contraindications and side effects

The use of injection solution is prohibited if there are contraindications. These include:

• severe liver failure;
• severe disturbances in the functioning of the renal apparatus (including severe failure, rapidly developing diseases of the organ, hyperkalemia);
• problems with blood clotting;
• chronic dyspepsia (prolonged pain in the epigastric region);
• a combination of asthma, intolerance to ASA or other NSAIDs, nasal polyposis and paranasal sinuses (the combination may be complete or incomplete);
• decompensated heart failure;
• individual intolerance to the components of the drug, tiaprofenic acid, salicylates, other NSAIDs;
• exacerbation of peptic ulcer;
• recent coronary artery bypass surgery;
• internal bleeding or suspicion of it;
• last 3 months of pregnancy;
• granulomatous enteritis, nonspecific ulcerative colitis;
• breastfeeding period;
• age up to 15 years.

During therapy, unwanted effects may occur. Side effects may occur from the following body systems:

1. Immune system: anaphylaxis.
2. Central nervous system: sleep problems, neuropsychic weakness, depressive states, headaches, dizziness, loss or confusion, paresthesia, polyneuropathy, convulsive syndrome, unstable emotional state, taste disturbances.
3. CVS: rapid heartbeat, hypertension, heart failure, relaxation of vascular smooth muscle.
4. Blood, lymph: hemorrhagic and hemolytic anemia, decreased levels of leukocytes and platelets, disorders of bone marrow hematopoiesis.
5. Respiratory system: exacerbation of asthma, swelling of the larynx, bleeding from the nose, bronchospasms, runny nose.
6. Gastrointestinal tract: vomiting, epigastric pain, dyspepsia, nausea, stool disorders, gastritis, severe gas formation, stomatitis, peptic ulcer disease. Bleeding, exacerbations of Crohn's disease and ulcerative colitis, perforation of the gastrointestinal tract, and stool with blood inclusions occur extremely rarely. There may be pain and discomfort in the intestines and stomach.
7. Sense organs: tinnitus, drying and inflammation of the conjunctiva, blurred vision, hearing loss, pain in the eyes, optic neuritis.
8. Biliary tract, liver: hepatitis, increased bilirubin levels and liver transaminase activity.
9. Urinary system: inflammation of the urethra and bladder, blood in the urine, kidney problems, hyperkalemia, water retention and resulting weight gain.
10. Skin: rashes, itching, photosensitivity, hair loss, urticaria (including exacerbation of the chronic form), bullous rash, purpura, Quincke's edema, Lyell's syndrome, erythema.
11. Others: peripheral edema, causeless fatigue, sputum with blood, difficulty breathing, muscle twitching, constant desire to drink, prolonged or intense bleeding from the uterus during menstruation.

Drug interactions

Ketonal is a solution that weakens the effect of diuretics and antihypertensive drugs, increasing the effectiveness of some anticonvulsants (phenytoin) and hypoglycemic drugs for oral administration.

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With the simultaneous use of thrombolytics, antiplatelet agents and anticoagulants, the risk of bleeding increases.

Concomitant use of ACE inhibitors, potassium-sparing diuretics, tacrolimus, trimethoprim and low molecular weight heparins increases the likelihood of hyperkalemia.

Ketoprofen increases the blood levels of CCB, cyclosporine, methotrexate, cardiac glycosides, and lithium-containing drugs.

Indications and contraindications for use

Ketonal helps in the treatment of the following diseases:

• inflammation of various etiologies;
• diseases of bone and joint tissues, which are accompanied by inflammatory processes and degenerative changes;
• various forms of arthritis;
• osteoporosis;
• diseases of the musculoskeletal system;
• gout;
• pain and aches in the muscles of various causes;
• inflammatory processes of nerve endings;
• inflammation that develops in the pelvis in women against the background of impaired functioning of internal organs.

Ketonal shows high effectiveness in relieving pain during the rehabilitation period after injuries and surgical operations. It is recommended to take for pain caused by intervertebral hernia, reactive inflammation of the articular tissue and between the vertebrae. The medication helps with prolonged intense headaches and migraines, if other medications do not give a positive result.

Ketonal is not used in the following conditions:

• individual intolerance to the components that make up the drug, a history of reactions to taking NSAIDs in the past;
• stomach or duodenal ulcer;
• gastritis;
• Crohn's disease;
• the presence of ulcerative colitis;
• abnormalities in the liver and kidneys;
• internal bleeding or tendency to it;
• blood diseases characterized by slow clotting, hemophilia;
• internal bleeding or tendency to it;
• 3rd trimester of pregnancy;
• breastfeeding period;
• dyspeptic disorders in chronic course;
• Age limit: under 15 years old.

Relative contraindications that require careful use of the drug are ulcers, bronchial asthma, and disorders of the digestive system.

Can the medicine be used during pregnancy?

The use of Ketonal in the 3rd trimester of pregnancy is strictly prohibited, since the medication reduces the intensity of labor.

In the 1st and 2nd trimesters, the drug can be used, but in extreme cases, when the doctor decides that the positive result from its use outweighs the risks of possible complications. Using Ketonal in the early stages increases the risk of spontaneous miscarriage.

There is no data on the penetration of the active substance into breast milk. It is not recommended to use Ketonal during lactation, only when absolutely necessary. During the period of use of the drug, breastfeeding should be suspended.

Features and Cautions

Pregnant and lactating women

In the first and second trimester, Ketonal is prescribed only in cases where the benefit to the mother outweighs the risk to the child. The third trimester suggests a complete ban on this drug, since ketoprofen can cause late and complicated labor. If taking Ketonal is necessary during breastfeeding, then the child is transferred to artificial formula.

Mechanism control

Ketoprofen does not directly affect the ability to control complex mechanisms or devices that require attention and reaction speed. But it is still not recommended to use it in such cases, since the list of side effects of the drug includes disorders of the nervous system.

Interaction with other drugs

Injections and other forms of Ketonal reduce the effectiveness of Mifepristone, diuretics and blood pressure lowering drugs, but enhance the effect of hypoglycemic medications (to reduce blood sugar levels).

In combination with other NSAIDs (Diclofenac, Aspirin, Ketorol, etc.), alcohol and glucocorticosteroids, it can provoke gastrointestinal bleeding. Impaired renal function is possible when Ketonal is taken simultaneously with diuretics and ACE inhibitors (Enalapril, Captopril, etc.). The risk of bleeding increases when ketoprofen is combined with any antithrombotic drugs, be it anticoagulants, thrombolytics or antiplatelet agents. When ketonal is combined with cardiac glycosides, Methotrexate, lithium preparations or calcium channel blockers, the blood concentration of these drugs increases.

Important instructions

Capsules and tablets can be taken with antacids such as Almagel, as well as milk, since they do not affect the rate of absorption and at the same time reduce the risk of developing complications from the gastrointestinal tract.

Long-term use of Ketonal (injections and other forms) involves monitoring the composition of the blood and the state of the kidneys and liver, especially for older people.

The drug should be used with caution and under the supervision of a doctor for hypertension and heart disease.

Interaction with other drugs

Considering Ketonal's ability:

• retain fluid in the body,
• inhibit renal microcirculation and glomerular filtration,
• block the synthesis of hypotensive prostaglandins.

Taking it together with the most prescribed antihypertensive drugs (diuretics, ACE inhibitors) leads to a weakening of their effect.

And in the case of combination with ACE inhibitors, it also leads to a deterioration in the nitrogen excretion function of the kidneys. This subsequently leads to progression of heart and kidney failure.

Patients who constantly take drugs that lower glycemia for diabetes (sulfonylurea derivatives - glibenclamide, glimepiride, gliclazide) experience inhibition of its metabolism, which potentiates the hypoglycemic effect and the development of hypoglycemic complications.

When combining Ketonal with blood thinning drugs (thrombolytics, disaggregants, anticoagulants), strict control of hemostasis is necessary due to the risk of developing hemorrhagic syndrome of any localization due to the antiplatelet effect of Ketonal.

In practice, patients often take several non-steroidal anti-inflammatory drugs at the same time to enhance the analgesic effect, which leads to the development of side effects in a short time without achieving the desired therapeutic effect.

For example, when using Ketonal with dexalgin in the form of an injection, which is an isoform of ketoprofen, the daily dose accumulates.

Ketoprofen prolongs the action of cardiac glycosides (digoxin) in the human body, which requires monitoring potassium levels and electrocardiographic parameters.

Alcohol intake potentiates the effect of Ketonal and, accordingly, increases the risk of bleeding and dizziness due to the joint metabolism of substances in the liver, which can also lead to damage to the liver tissue.

Ketonal suppositories enhance the nephrotoxicity of methotrexate and cyclosporine, increasing their concentration in the blood.

Combined use with glucocorticosteroids increases the likelihood of side effects.

Women should note that Ketonal suppositories reduce the effectiveness of mifepristone. Only 8-12 days after its discontinuation is it possible to take NSAIDs

Patients with mental disorders taking lithium-based drugs require dose adjustment of Ketonal due to its ability to increase lithium toxicity.

Ketonal goes well with narcotic analgesics. With tramadol in one syringe it precipitates.

The drug Ketorol composition and release forms

Of course, first you should familiarize yourself with the list of ingredients and other useful information. This drug is produced in the form of round convex tablets with a green hard shell (on the cut you can see a white or slightly grayish tablet core).

What components does the medicine “Ketorol” consist of? Composition is an important point. The main active substance is ketorolac tromethamine (each tablet contains 10 mg). Other components are also present, in particular corn starch, lactose, magnesium stearate, microcrystalline cellulose, sodium carboxymethyl starch and silicon dioxide (colloidal) are excipients. The film shell contains propylene glycol, green dye and hypromellose.

By the way, you can also buy Ketorol injection solution at the pharmacy. Injections are indicated for severe pain. This product is also produced in the form of a gel for external treatment of tissues.

Description of the drug and dosage dosage

Ketorol is a non-steroidal anti-inflammatory drug with a strong analgesic effect. The active ingredient is ketorolac tromethamine or ketorolac. The drug has antipyretic, analgesic and anti-inflammatory properties. Ketorolac by its action inhibits the formation of prostaglandins, which play an important role in inflammatory and pain processes. The substance does not inhibit the functioning of the respiratory center, does not have a negative effect on opioid receptors, does not have an antidepressant or sedative effect, and is not addictive. Ketorol's analgesic effect is similar to morphine and is largely superior to NSAIDs of other groups. The analgesic effect begins half an hour after intramuscular injection and an hour after administration. The greatest effect is achieved after 1-2 hours.

The composition of the tablets and the drug in ampoules includes tromethamine ketorolac and additional inactive substances.

The main indications for use are blocking pain of varying severity, manifested for any reason, including oncology and postoperative pain.

Release form: tablets, ampoules, suppositories (suppositories), ointment, gel.

Mode of application:

1. Tablets are prescribed orally once. The dosage depends on the severity and intensity of the pain. If necessary, the dose is repeated, but without exceeding the maximum allowable dose of 4 tablets per day, i.e. 40 mg. You should not take the drug for more than five days in a row.
2. Injections are administered intramuscularly. The dosage is prescribed individually depending on the intensity of pain. If necessary, the amount of the administered drug is adjusted. It is allowed to take opioid analgesics in reduced doses in parallel. The maximum dose for intramuscular injections is 90 mg per day for patients under 65 years of age, a single injection is given in a volume of 10-30 mg. After the age of 65 years, the dosage of Ketorol should be reduced to 10-15 mg at a time, and the maximum possible dose should be no more than 69 mg per day, especially in cases of renal impairment. The medication is administered for no longer than five days.
3. Ointment and gel are used to relieve pain in post-traumatic inflammation of muscles, ligaments, and joints. For soft tissue injuries, sprains, dislocations, bursitis, tendonitis, epicondylitis, inflammation of the synovial membrane, osteoarthritis of the superficial joints.

In some cases, it is necessary to switch from intramuscular injections to oral administration of the drug in tablets. In this case, the maximum permissible dose of the drug should also be observed. The total daily dose of the drug in any form of release is no more than 90 mg per day for people under 65 years of age, and 60 mg per day for people over 65 years of age.

Characteristics of Ketonal

This is a non-narcotic, non-hormonal drug, characterized by antipyretic, anti-inflammatory and analgesic properties. It helps relieve moderate and severe pain of various origins, for example, with colic, neuralgia, myalgia, radiculitis, osteoarthritis, spondylitis, arthritis, etc.

Dosage forms of Ketonal:

• pills;
• gel;
• cream;
• rectal suppositories;
• solution in ampoules for intravenous or intramuscular administration;
• capsules.

The main active component of the drug is ketoprofen. This substance belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs). A distinctive feature of the drug is the provision of a wide range of analgesic effects, distributed to the peripheral and central nerve fibers that are responsible for the perception of pain impulses. Therefore, Ketonal is often used for pain in joints, muscles, and ligaments. The drug reduces inflammatory reactions, which helps relieve pain in joint diseases and relieves morning stiffness.

Tablets, injections, suppositories and capsules are prescribed for the treatment of degenerative or inflammatory diseases of cartilage, ligaments, muscles, joints and bones:

• rheumatoid arthritis;
• glenohumeral syndrome;
• rheumatism;
• gout and pseudogout;
• osteochondrosis;
• osteoarthritis;
• arthrosynovitis;
• periarthritis;
• polyarthritis;
• reactive arthritis;
• ankylosing spondylitis;
• psoriatic arthritis.

To relieve pain, doctors often prescribe drugs such as Ketonal or Ketorol.
In addition, these dosage forms are prescribed to relieve severe or moderate pain in the following diseases and conditions:

• phlebitis;
• lumbago;
• lumbodynia;
• sciatica;
• radiculitis;
• neuralgia;
• myalgia;
• headache;
• bursitis;
• tendinitis;
• lymphadenitis and lymphangitis;
• pain after operations, injuries, during menstruation and malignant tumors.

Gel and ointment are indicated in the following cases:

• periarthritis and rheumatoid arthritis;
• neuralgia;
• myalgia;
• bursitis, tendinitis;
• osteoarthritis;
• reactive arthritis;
• psoriatic arthritis;
• ankylosing spondylitis;
• ruptures of tendons and muscle ligaments, sprains, bruises of ligaments and muscles, injuries to the musculoskeletal system;
• radiculitis.

Contraindications for Ketonal include:

• intolerance to drugs of the NSAID group;
• bleeding disorders;
• exacerbation of inflammatory bowel diseases (enteritis, Crohn's disease, etc.);
• exacerbation of a stomach or duodenal ulcer;
• chronic digestive disorders (constipation, diarrhea, flatulence, etc.);
• bleeding of any location (uterine, gastrointestinal, etc.);
• coronary artery bypass grafting performed less than 2 months ago;
• heart failure;
• progressive kidney disease;
• severe liver or kidney failure;
• third trimester of pregnancy;
• breastfeeding;
• children under 15 years of age.

Contraindications for Ketonal include: intolerance to NSAIDs, blood clotting disorders.
Cream and gel should not be applied to wounds on the skin (wetting dermatitis, eczema, open wound, etc.).

Ketanov indications

Ketanov's indications relate to the elimination of severe pain that occurs for various reasons.

Both tablets and injections are prescribed for the same pathologies and symptoms. The dosage form depends on the patient’s preferences, the risk of side effects or individual intolerance to the auxiliary components in Ketanov.

Pain can be relieved with the drug in the following pathologies:

• Ailments of the oral cavity, for example, dental diseases;
• Disorders of the musculoskeletal system;
• Particularly severe headaches;
• Formation of malignant tumors;
• Colitis;
• Ear diseases;
• Discomfortable sensations after childbirth and during menstruation.

Separately, it is worth highlighting the use of the product for the treatment of pathologies of the back and joints. For example, Ketanov copes well with pain due to osteochondrosis or osteoarthritis.

Effect of the drug

Like other propionates, ketoprofen works by affecting the enzymes COX1, COX2. It does not have a selective effect, therefore it affects all foci of the presence of these substances that are involved in the production of prostanoids (prostaglandins and other mediators of pain and inflammation). The result is suppression of enzyme production and a decrease in the inflammatory response, which occurs both locally and in the central nervous system and hypothalamus.

Ketonal also acts in a different way. It suppresses the production of bradykinin, a substance that dilates blood vessels, which is one of the factors responsible for pain sensitivity. Inhibiting the release of this peptide also reduces pain. The medicine also affects leukotrienes - these substances cause spasms, trigger allergic-inflammatory reactions, also participating in inflammation. Administration of Ketonal provides the following effects:

• analgesic;
• anti-inflammatory;
• decongestant;
• antipyretic.

By stabilizing liposomal membranes, the use of the drug helps reduce cell damage that occurs during inflammation. The active substance penetrates well into the synovial fluid without damaging articular cartilage. It is easily absorbed from the small intestine with a bioavailability of 90%, the peak concentration is detected after 1.3 hours, and is not affected by food intake. When administered intravenously, the maximum effect develops within 20 minutes. The medicine is excreted by the liver, which imposes restrictions on therapy for diseases of this organ.

pharmachologic effect

The active component ketoprofen blocks the action of the enzyme cyclooxygenase, partially lipoxygenase. This leads to suppression of prostaglandin synthesis, including in the central nervous system and hypothalamus. The product stabilizes liposomal membranes, inhibits the synthesis of bradykinin and leukotrienes. Ketoprofen does not have a negative effect on articular cartilage.

When used rectally, the active component is quickly absorbed, reaching maximum concentration after 2 hours. Ketoprofen has 90% bioavailability and is 99% bound to plasma proteins (albumin). The substance is actively metabolized with the participation of microsomal liver enzymes and has a 2-hour half-life.

Ketoprofen binds to glucuronic acid and is excreted as a glucuronide. The drug does not form active metabolites and is excreted by the kidneys and through the intestines. In old age, pharmacodynamics slow down.

Patient opinions

The vast majority of those who have used Ketonal speak extremely positively about the various forms of the drug.

1. Svetlana, 20 years old: “I injured my back while playing sports and now periodically experience severe pain. I tried to take many painkillers, but Ketonal became a real salvation for me!”
2. Igor, 48 years old: “Ketonal-gel was recommended to me after I severely sprained the ligaments in my leg. The drug helped, now I always keep it in my medicine cabinet, just in case.”
3. Marina, 36 years old: “After gynecological surgery, I experience severe pain during menstruation. Only taking Ketonal Duo helps to forget about them. “I have never experienced any side effects.”

Use during pregnancy, breastfeeding and children

It is not recommended to take Ketonal at the stage of maternity planning due to decreased fertility , increased risk of miscarriage and the development of heart disease in the fetus.

In the first and second trimesters: use Ketonal suppositories only as prescribed by a doctor, with an assessment of the expected benefits and potential harm.

In the third trimester - contraindicated due to the ability of anti-inflammatory drugs to inhibit labor and prolong bleeding.

If use is necessary during lactation, you should consider stopping breastfeeding.

Ketonal suppositories are not used in children under 15 years of age.

Release form, composition and packaging

Today there are several types of medicine:

• pills;
• ointment (cream);
• gel;
• solution for injections;
• candles;
• Ketonal Duo capsules.

• active substance of capsules - ketoprofen 150 mg, auxiliary ingredient - lactose;
• rectal suppositories contain 100 mg of ketoprofen;
• the solution contains ketoprofen (50 mg per 1 ml), a little propylene glycol, alcohol, purified water;
• the main component of the tablets is ketoprofen 100 mg, auxiliary components are magnesium stearate, corn starch, talc powder, lactin, silicon dioxide;
• the ointment contains 50 mg of ketoprofen, propylene glycol, paraffin, magnesium sulfate, methylparaben, water for injection;
• The gel combines ketoprofen 50 mg, propylene glycol, petroleum jelly, magnesium sulfate, lavender extract, alcohol solution, glyceryl, and pure water.

Medicines are produced in the following packages:

• tablets, capsules - glass bottles;
• gel, ointment - aluminum tubes with a lid;
• rectal suppositories - strips;
• solution for injections - glass ampoules.

All of the above types of medicine are packaged in cardboard boxes.

Rectal suppositories Ketonal: indications for their use

The active ingredient of these suppositories is ketoprofen, which is part of the group of non-steroidal drugs with an anti-inflammatory effect. This substance can soothe even severe pain and stop fever.

Indications

Rectal suppositories Ketonal are used for various diseases to relieve pain. For example, women can use suppositories for painful menstruation.

The active substance of the drug has not only analgesic properties, but also a therapeutic effect. Therefore, suppositories can be used to treat rheumatic diseases such as gout, shoulder capsulitis, post-infectious reactive arthritis and other diseases.

Drugs based on ketoprofen have a wide range of effects on the human body. Thus, it is often used in proctology for the treatment of external and internal hemorrhoids at different stages of inflammation, with bleeding from the anus or with wounds in this area, as well as inflammation of the rectum.

If there is bleeding from the anus, before using these suppositories, it is important to first find out whether this fact is related to any formation in the rectal area. In this case, the doctor will prescribe appropriate treatment for you.

Contraindications

The drug Ketonal can be purchased freely in any form. However, experts do not recommend using it for self-treatment. The fact is that for effective treatment it is necessary to know the exact diagnosis of the disease. And this can only be done by a doctor with the help of good diagnostics. It happens that patients simply relieve pain with the help of medications, without knowing or conducting therapeutic therapy for the underlying disease.

As a result, over time the disease begins to progress to a more severe form.

It is important to know that Ketonal (rectal suppositories) is not suitable for all patients. And this is the reason to seek help from a doctor.

The drug has contraindications, which include intolerance to the elements included in its composition, an allergic reaction to the active substance, bleeding in the gastrointestinal tract, heart and kidney disease.

Only in some cases does the doctor prescribe this drug to patients who suffer from anemia, cirrhosis of the liver, diabetes mellitus, and blood diseases. Treatment of elderly patients with rectal suppositories must be carried out under the watchful supervision of a specialist.

Side effects

When using Ketonal suppositories, side effects are rare. They may appear if the drug is used for a long time. With proper use and dosage of the drug, the treatment is gentle, without causing bad consequences.

The body's negative reaction during treatment with suppositories mainly affects the gastrointestinal tract. During this period, heartburn, nausea, vomiting, poor digestion of food, discomfort after eating, and failure to defecate may occur.

The main side effects include pain in the lower abdomen, burning sensation, allergies in the form of various skin rashes, etc. Some other systems may also react negatively, resulting in headaches, mild dizziness, and disturbed sleep.

Side effects that occur during treatment with rectal suppositories must simply be monitored. When the patient has an uneasy feeling about this, discomfort increases, you should visit a doctor. Consultation with a specialist is also necessary in cases where an allergic reaction and tinnitus occur.

Rectal suppositories should be used only as prescribed by a doctor or strictly following the recommendations specified in the instructions. If the permissible composition level has been exceeded, there is a greater risk of side effects. In this case, when going to the doctor, be sure to show him the packaging of the medicine you are using.

Rules for taking capsules

Capsules should not be bitten or chewed. They are swallowed whole, along with the shell, washed down with plenty of liquid. As a rule, ordinary water is used for these purposes. Drink Ketonal with food or immediately after taking it.

Use on an empty stomach is also not prohibited, but then unpleasant and painful sensations may occur.

Treatment rules:

1. Frequency of administration – up to 3 times a day.
2. Single dosage – 1 capsule (if necessary, the quantity can be increased to 2 pieces).
3. Stop taking when the required result is achieved.

The frequency of taking Ketonal Duo and Uno is once a day.

Rules for using candles

The dose of the drug is determined by the doctor. It is strictly not recommended to administer more than 2 suppositories per day, because there are no specific drugs to treat an overdose. Usually, the symptoms of an overdose are quite mild and can be relieved with symptomatic methods. But you shouldn’t overdose.

Suppositories, regardless of the reason for prescription, are administered exclusively rectally. They can be combined with other forms of this medication to enhance the effect. The drug is used until the condition is normalized and the patient can lead a normal lifestyle.

Basic Rules:

1. Suppositories are administered after defecation. If the patient has problems with bowel movements, then she is recommended to do a microenema or take a mild laxative.
2. After defecation, it is recommended to wash the anus and external genitalia with warm water and soap.
3. To ensure that insertion of the suppository causes minimal discomfort, it is recommended to sit down and gently push the suppository into the rectum. The candle must be inserted as deeply as possible.

Side effects

Ketonal, side effects occur when prohibitions on use are ignored or the drug is used uncontrolled.

• stomach ache;
• nausea, urge to vomit;
• diarrhea;
• stomatitis;
• dryness in the oropharynx;
• bleeding in the stomach;
• liver pathologies;
• migraine;
• sleep problems;
• excessive fatigue, nervousness;
• problems with diction;
• hypertension, rapid heartbeat;
• swelling;
• conjunctivitis, accompanied by pain in the eyes;
• agranulocytosis;
• bloody discharge in the urine;
• exacerbation of kidney disease.

Sometimes the remedy entails allergic reactions, characterized by bronchopulmonary spasm, shortness of breath, Quincke's edema, and runny nose. And the use of Ketonal cream or gel causes swelling, skin rashes, urticarial rash, necrosis, and dermatitis.

Overdose

If Ketonal is taken in a daily dose exceeding 2.5 mg, there may be abdominal pain, nausea, vomiting, drowsiness, and convulsions. You should immediately consult a doctor or call an ambulance.

It is recommended to rinse the stomach, take sorbents (Polysorb, Filtrum, Enterosgel, Phosphalugel), antihistamines (Suprastin, Cetirizine), drugs that reduce the secretion of gastric juice (Omeprazole, Rabeprazole). There is no specific antidote.

Basic pharmacological properties

The main active component of the ointment, ketoprofen, belongs to the group of non-steroidal anti-inflammatory substances. Thanks to it, the drug has analgesic, anti-inflammatory and antipyretic effects.

Ketoprofen blocks the work of specific enzymes lipogenase and cyclooxygenase, which are responsible for the synthesis of prostaglandins. It is these substances that are responsible for the appearance and development of the inflammatory process, and also cause pain and fever. Ketoprofen affects not only the central, but also the peripheral nerve fibers, which are responsible for the perception and transmission of pain impulses. That is why Ketonal is considered a highly effective pain reliever. In addition, for joint diseases, the cream eliminates stiffness and swelling of the affected areas.

Adsorption of the active substance into the systemic circulation is minimal, but increases if the ointment is used for a long period. The exchange and excretion of metabolites occurs in the skin and subcutaneous tissues.

Mechanism of action

Rectal suppositories Ketonal are prescribed for inflammatory diseases of the pelvic organs. The drug has an analgesic effect and quickly eliminates pain. Thanks to the active element ketoprofen, suppositories have the ability to raise the pain level by inhibiting enzymes from lysosomal membranes.

On average, the concentration of the active component in the blood reaches 1 hour 20 minutes after using the medication. This indicator may vary depending on the individual reactions of the body.

In proctology, the medicine is used to treat hemorrhoids. Ketonal suppositories have a wide spectrum of action and help restore blood pressure in the rectal area, which promotes the resorption of nodes. Also, rectal use increases the elasticity of the veins and strengthens the vascular network.

Suppositories help facilitate blood flow in the pelvic organs. Thanks to the use of a drug based on ketoprofen, capillary absorption improves, the inflammatory process decreases, blood clots resolve, and the blood becomes much thinner.

special instructions

There are a number of special instructions that should be followed when using the drug Ketonal DUO in treatment.

Ketoprofen can interact significantly with other drugs; in particular, the drug can weaken the effects of diuretics and a number of antihypertensive drugs, while enhancing the hypoglycemic effect of oral hypoglycemic drugs, as well as a number of anticonvulsants (phenytoin).

Concomitant use with potassium salts, potassium-sparing diuretics, angiotensin-converting enzyme inhibitors, other NSAIDs, trimethoprim, low molecular weight heparins, cyclosporine, tacrolimus increases the risk of hyperkalemia in the patient.

Ketonal increases plasma concentrations of cardiac glycosides, blockers of “slow” calcium channels, lithium salts, cyclosporine, methotrexate and digoxin. The drug also increases the toxicity of methotrexate and the nephrotoxicity of cyclosporine.

Concomitant use with probenecid significantly reduces the clearance of ketoprofen in the blood plasma.

All NSAIDs can reduce the effectiveness of mifepristone

Therefore, it is important to start taking NSAIDs no earlier than 1-2 weeks after stopping the last one.

Ketonal DUO should not be combined with other cyclooxygenase inhibitors

With a long course of treatment with NSAIDs, it is necessary to systematically assess the state of the general picture of blood tests, kidney and liver function, which has a special role in elderly patients (over 65 years old); it is also important to conduct a stool test several times during a long course of treatment (more than a year) for hidden blood

If any visual disturbances associated with drug therapy are detected, Ketonal DUO should be stopped immediately.

Like other NSAIDs, Ketonal is able to blur the clinical picture of infectious and inflammatory diseases. If during the use of ketoprofen there were signs of infection or deterioration in health, you should immediately consult a doctor.

The use of ketoprofen can affect female fertility; therefore, patients with infertility (including those undergoing examination) are not recommended to take the drug.

There is no data on the negative impact of Ketonal DUO in therapeutic doses on the ability to drive a car or operate complex machinery.

In this case, caution must be exercised, since the drug can cause dizziness, as well as a number of other side effects.

Use during pregnancy and breastfeeding

Inhibition of prostaglandin synthesis may have undesirable effects on pregnancy and/or embryonic development. Data obtained from epidemiological studies with the use of prostaglandin synthesis inhibitors in early pregnancy confirm an increased risk of spontaneous abortion and the formation of heart defects (~1-1.5%). The drug can be used by pregnant women in the first and second trimesters of pregnancy only if the benefits for the mother justify the possible risk to the fetus. The use of ketoprofen in pregnant women during the third trimester of pregnancy is contraindicated due to the possibility of developing weakness of labor in the uterus and/or premature closure of the ductus arteriosus, a possible increase in bleeding time, oligohydramnios and renal failure. To date, there is no data on the release of ketoprofen into breast milk, therefore, if it is necessary for a nursing mother to use ketoprofen, the issue of stopping breastfeeding should be addressed.

Characteristics of Ketorol

This is a powerful analgesic with a fairly weak antipyretic and anti-inflammatory effect. It is most often prescribed to relieve moderate to severe pain, especially associated with injuries. The drug helps if the back hurts or a person suffers from migraines, neuralgia, radiculitis. Dosage forms: tablets, gel, solution for intravenous and intramuscular administration. The main component is ketorolac.

The mechanism of action of the drug is based on its ability to block the work of cyclooxygenase, a special enzyme that converts arachidonic acid into prostaglandins. These are substances that provoke the development of pain, inflammation and an increase in body temperature.

Ketorol thins the blood well, so it is prescribed with caution to people suffering from diseases associated with bleeding (stomach ulcers, hemophilia, etc.)

Indications for use of the drug:

• injuries (synovitis, tendonitis, bursitis, ligament damage, soft tissue inflammation, bruises, etc.);
• radiculitis;
• neuralgia;
• pain in joints and muscles;
• osteoarthritis;
• pain syndrome after injury.

The analgesic effect of the drug is aimed at relieving pain, but does not eliminate its cause and does not cure the underlying disease. An overdose of the gel is impossible, but if it accidentally gets into the stomach, for example, when licked from hands, lips, etc., then you need to induce vomiting and take some kind of sorbent (activated carbon, Enterosgel, Polysorb).

Overdose with injection solution and tablets is possible. It manifests itself as symptoms of poisoning: nausea, vomiting, abdominal pain. In addition, other undesirable effects of the body may be observed:

Ketorol helps if the back hurts or a person suffers from migraines, neuralgia, radiculitis.

Ketorol is contraindicated in the following cases:

• “aspirin” asthma;
• hemorrhagic diathesis and stroke;
• renal and liver failure;
• decreased blood clotting;
• peptic ulcers;
• ulcers and erosions of the digestive organs;
• dehydration;
• hypovolemia;
• angioedema (in the past);
• bronchospasm;
• impaired hematopoiesis in the bone marrow;
• high risk of bleeding;
• simultaneous use with other NSAIDs;
• children under 16 years of age;
• pregnancy, breastfeeding;
• intolerance to the components of the drug.

Nuances of use

In gynecology

Ketonal is widely used for the treatment of various female diseases that are inflammatory in nature. The medicine is widely used after manipulations such as abortions, endoscopic interventions and operations.

Using the medicine during menstruation is strictly prohibited. If the patient experiences menstruation, the course of treatment must be suspended until it ends.

During pregnancy and lactation

Since the components of the medication are able to penetrate the placental barrier, the use of suppositories by a woman during pregnancy is strictly prohibited. You should not use the medicine while breastfeeding newborns.

After cesarean section and childbirth, taking the medication is strictly prohibited.

For prostatitis

The medicine can fight a variety of inflammatory processes. That is why it is widely used to treat prostatitis. Also, with its help, the consequences of this disease are eliminated.

In childhood

If the child’s age is less than 14 years, then using the medication for its treatment is strictly prohibited.

Instructions for use

Pills

The dose should be prescribed by a doctor, taking into account the individual characteristics of the body. Usually the daily dose does not exceed 1 tablet, but there may be exceptions. Do not take more than 2 tablets per day.

The medicine should be taken with meals, washed down only with clean water. Do not drink tea, coffee or carbonated drinks.

Ointment (cream)

The ointment is suitable for external use only; it is not recommended to use it simultaneously with other creams.

Apply ointment to the affected area using medical gloves. At the end of the procedure, wash your hands thoroughly. After allergic manifestations, immediately stop using the product and consult a doctor.

Gel

Apply a little gel to the sore spot and distribute the product over the skin with massaging movements. You can use the product no more than 3 times a day. Treatment without medical advice should not last more than 2 weeks.

Intramuscular and intravenous injections

Injections speed up the release of the drug into the blood, so the doctor prescribes one ampoule three times a day. It is effective to take the whole complex - suppositories and tablets.

Intravenous administration is usually prescribed to patients undergoing hospital treatment. The use of the medicine occurs with or without interruptions. For intermittent administration, a dropper is used: two ampoules of the product must be diluted with 100 milliliters of glucose solution and injected into the patient’s vein. After 7-8 hours, repeat the manipulation. For continuous administration, the dropper is made in this way: two ampoules need to be diluted with 500 milliliters of glucose solution, injected into a vein, and repeated after 9-10 hours.

Candles

For elderly patients, suppositories should be placed only after consultation with the doctor, as there is a risk of internal bleeding that is not accompanied by external manifestations.

Capsules

It is recommended to drink 1 capsule three times a day to relieve severe pain. Drink only clean water. You should not take more than 6 tablets per day.

How to use injections?

A solution for intravenous or intramuscular administration is indicated when quick and effective pain relief is necessary, as well as if for some reason oral administration is not possible. The injection form can be combined with oral (tablets, capsules) and rectal (suppositories) forms of the drug. The duration of use of injections and all other forms of Ketonal is determined by the speed of pain elimination. Moreover, the maximum permitted daily dose of the drug has been established, regardless of the release form - this is 200 mg.

Each ampoule contains 2 ml of solution for injection containing 100 mg of ketoprofen. Intravenous administration is prescribed 1-2 times a day, 1 ampoule (100 mg each). Injections are given where the muscles are located close to the skin (top of the shoulder or thigh). It is not recommended to inject into the buttock, since a layer of subcutaneous fat may prevent the medicine from fully penetrating into the muscles and reduce effectiveness.

Ketonal injections intramuscularly, if you have mastered the equipment, can be done at home. Intravenous infusions of the solution are performed exclusively in a hospital setting by a medical professional.

Never administer droppers with Ketonal yourself - this can be dangerous to life and health.

Your doctor may prescribe short or long drips. In the first case, 1-2 ampoules of the drug (100-200 mg of ketoprofen) are taken per 100 ml of physiological solution and administered drip-wise over 30-90 minutes. In the second case, a similar volume of Ketonal is dissolved in 500 ml of saline and a dropper is placed for 8 hours. Between procedures for intravenous administration of the drug, regardless of duration, at least eight hours must pass.

You may be interested in reading: Ketanov: instructions for use, tablets and injections

Possible side effects that occur during treatment

This medicine may cause unwanted side effects in some cases. The list of them is quite impressive, but it is worth saying that in medical practice they are rarely recorded and, as a rule, are associated with improper use.

• The drug can affect the nervous system, causing headaches, increased drowsiness, and dizziness. Paresthesia, convulsions and distortion of taste sensations are much less common. Sometimes patients also complain of tinnitus and blurred vision.
• Possible side effects from the digestive system, including nausea, vomiting, stool disorders, bloating. Much less frequently, therapy leads to the development of gastritis, exacerbation of Crohn's disease, and the appearance of gastrointestinal bleeding.
• Side effects include allergic reactions, which include hives, skin rashes, itching, and swelling. Anaphylactic shock develops much less frequently.
• During therapy, disturbances in the functioning of the respiratory system may occur, including nosebleeds, bronchospasm, severe rhinitis, asthmatic attacks, and laryngeal edema.
• Sometimes there is an increase in the level of liver enzymes and bilirubin.
• Possible impairment of kidney function up to renal failure.
• Other side effects include fatigue, swelling, weight gain, hypertension, and hemorrhagic anemia.

If any deterioration occurs, you should immediately stop therapy and report your symptoms to your doctor.

Types of suppositories for prostatitis

Since prostatitis can manifest itself in different forms and stages, it is important to use the prescribed medicine correctly. In pharmacies you can find many types of suppositories that are effective for prostatitis, not only domestically produced, but also foreign ones

Each type has different components and area of ​​influence. The main types of rectal suppositories are suppositories:

• with antibiotics;
• with antispasmodics;
• suppositories that have an anti-inflammatory effect;
• with honey product (propolis);
• with royal jelly;
• from wax;
• with parts of animal prostates.

Also, suppositories based on bee products are effective for prostatitis.

Ketonal's analogs

• Ketoprofen.
• Ortofen.
• Diclofenac.
• Ketanov.
• Movalis.

Ketoprofen and Ketonal - what is the difference?

The main active ingredient in both drugs is ketoprofen. These agents have an almost identical mechanism of action, but in order to make the right choice, you should familiarize yourself with their differences.

1. Ketonal and Ketoprofen are presented in the same release forms, except that the first product is manufactured in Slovenia or by a German organization, and its opponent is produced by Russian companies, Vertex.
2. Ketoprofen is safer for children; in pediatrics it is prescribed from 6 years of age. Ketonal cannot boast of such an advantage; it is more suitable for teenagers.
3. The cost of the analogue ranges from 70-180 rubles, and the price of Ketonal is higher.

What to choose, Ketonal or Ketoprofen, depends on the desires of the consumer. The analogue is cheaper, therefore, it is considered more affordable. Those who trust European production more than domestic ones, Ketonal is suitable. In addition, the German drug causes fewer side effects.

Flamax or Ketonal - what to choose?

Flamax, like Ketonal, belongs to a number of non-steroidal anti-inflammatory drugs based on propionic acid. The active substance is ketoprofen. These funds have a number of differences.

1. Flamax has the same effects as Ketonal, but this product has higher absorption and bioavailability (90%).
2. An analogue is produced in Russia, and Ketonal is produced in Germany. The cost of Flamax is 100-150 rubles, which is cheaper than the opponent.
3. Contraindications and side effects are the same for both drugs.
4. Flamax is produced in the form of ampoules, capsules, tablets, rectal suppositories, and Ketonal has a wider selection of production forms.

To eliminate pain due to pathologies of the musculoskeletal system, preference should be given to Ketonal, the drug has a stronger antispasmodic effect.

Ketanov and Ketonal - which is cheaper?

Both drugs are not considered full-fledged analogues, since they have a number of significant differences.

1. Ketanov and Ketonal have different active ingredients, in the original it is ketoprofen, and the opponent includes ketarolac in its composition. Despite this nuance, both elements are comparable in effectiveness to morphine; Ketonal is evacuated from the body faster and has fewer side effects. Due to this nuance, the drug is prescribed to older people.
2. Ketonal can be used in conjunction with other medications at minor oral dosages.
3. Ketanov's action begins 40 minutes after internal administration, and reaches its maximum effect after 2 hours, and its brother is famous for the same.
4. Ketonal is more effective for eliminating long-term pain in a chronic form.
5. Ketanov is produced in India, its cost ranges from 70 to 250 rubles, depending on the form of release. This is slightly cheaper than the price of Ketonal.

If you choose between these drugs, you should rely on your doctor’s recommendations. Note: Ketanov has a more powerful analgesic effect, while his opponent has an anti-inflammatory effect.

Ortofen or Ketonal - what to choose for osteochondrosis?

Ketonal and Ortofen have the same effect, but their similarities end there.

1. Ketonal has a stronger effect on severe pain due to diseases of the musculoskeletal system; the product allows you to quickly relieve discomfort without harming the articular cartilage. The medicine is inferior in power to Ortofen, this medicine is more effective in inflammatory processes.
2. Both drugs are rarely used in pediatrics. Ortofen is manufactured in Kharkov, Ukraine. Cost - from 40 to 170 rubles, depending on the form of release. In terms of price, Ketonal's analogue is cheaper.
3. Ortofen has a large list of side effects, they occur more often than after using Ketonal.

If you choose between Ketonal and Ortofen for pain caused by diseases of the musculoskeletal system, it is better to give preference to the first remedy. Ortofen is more suitable for eliminating inflammation. Lovers of European quality will appreciate Ketonal, and admirers of domestic production will appreciate Ortofen.

Description of the substance

The active ingredient of the drug Ketonal is ketoprofen. In suppositories, the dosage of the active component is 100 mg. The drug belongs to the pharmacological group NSAIDs (non-steroidal anti-inflammatory drugs).

Suppositories are applied rectally and can be used to treat men and women. Ketonal is prescribed for inflammation of the urinary system. The remedy is indicated for prostatitis, hemorrhoids, diseases of the uterus and appendages.

The active substance ketoprofen does not accumulate in the human body. No negative effects on the bone and cartilage system were detected. The component has the ability to eliminate pain and fight swelling.

The mechanism of action is associated with the blockade of prostaglandins E2, suppression of COX (cyclooxygenase) activity, inhibition of bradykinin synthesis and stabilization of lysosomal membranes. All these effects provide its high anti-inflammatory activity, which reduces the manifestations of inflammatory and degenerative diseases and provides a lasting analgesic effect.

Action of the active substance:

1. Oral administration. The maximum concentration of ketoprofen in the blood reaches a few hours after administration, absorption in the gastrointestinal tract is high. Tablets act faster than regular long-acting medications.
2. Use of rectal suppositories. Intestinal absorption is much higher. The effect of the active component occurs within 1 hour after administration. The half-life lasts about 2 hours. If liver function is impaired, the effect of the drug slows down for 1 hour.
3. Intravenous administration. The use of ketoprofen intravenously helps to achieve the maximum concentration of the active substance in the blood within 5 minutes after injection.

Usually, 1 tablet or suppository is sufficient to eliminate pain. No dose adjustment is necessary depending on the patient's age or weight. The doctor may change the dosage if the patient has a history of renal failure.

Contraindications

Nonsteroidal anti-inflammatory drugs are not completely safe medications. These drugs have a number of general contraindications that Ketonal also has.

To prevent unwanted effects, you should consult a specialist before using the medicine. Contraindications to the use of ketorofen preparations:

• History of allergy to the components of the product.
• Combinations of allergic diseases with episodes of asthma.
• Peptic ulcer disease.
• Blood clotting disorders.
• Use in childhood.
• Liver failure.
• Severe kidney failure.
• Severe cardiovascular failure.
• Pregnancy (3rd trimester).
• Lactation.
• Continued bleeding.

The product should be used with caution if the gastric mucosa is infected with the bacterium Helicobacter pylori. Confirmed infection caused by this microorganism increases the risk of gastric ulcers and their severe complications

Ketanov contraindications

Contraindications to Ketanov can be divided into absolute and relative. In the first case, you will have to abandon the medicine and replace it with another remedy. Relative restrictions allow for careful use of the medication.

The main contraindications to Ketanov include:

• Hypersensitivity to the active substances and auxiliary components in the composition of the product;
• Past or current history of aspirin-induced asthma.
• Bronchial pathologies;
• Edema of angioneurotic type;
• Insufficient amount of fluid in the body;
• Blood circulation disorders;
• Gastrointestinal pathologies;
• Leg ulcers;
• Problems with blood clotting;
• Kidney disease, excessive concentration of creatinine in the body;
• Risk of hemorrhagic stroke;
• Diathesis;
• Predisposition to bleeding;
• The period of gestation and lactation;
• Constant pain;
• Childhood.

How it works

Today, NSAIDs in general, and drugs containing ketoprofen in particular, are considered a promising line in protecting pain receptors (nociceptors). And therefore, in pain relief. This is achieved by changing the threshold of sensitivity to pain.

Cyclooxygenase is not a pain mediator, that is, it does not contribute to the formation of a pain signal, but it makes nociceptors more sensitive to pain. NSAIDs suppress the synthesis of this substance, therefore, pain receptors remain insensitive to irritation.

Cyclooxygenase is conventionally divided into two forms: COX-1 and COX-2. According to their mode of action, all NSAIDs are classified as substances:

• Selectively acting on one of these forms (COX2).
• Suppressing the synthesis of both forms.

In the former, the negative impact on the stomach and intestines is minimized, the risk of developing allergic reactions and inadequate reaction of the urinary system is reduced. But as painkillers they are significantly inferior to non-selective COX inhibitors. The latter are more effective as analgesics, but also have a wider list of side effects.

Ketoprofen is a non-selective cyclooxygenase inhibitor, which means it has a very strong analgesic effect.

How to use ketans for toothache

Ketanov for toothache not only helps relieve pain, but also reduces swelling of the tissue surrounding the tooth root. This further facilitates the treatment process and the dentist’s work. If you took a ketan tablet before visiting the dentist, inform your doctor about this fact. He will take this circumstance into account when injecting an anesthetic drug. To quickly relieve suffering from toothache, Ketanov is taken depending on the age of the patient, 1-2 tablets at a time.

Can ketans be used during pregnancy?

It is strictly forbidden to take Ketanov during pregnancy. Ketanov is similarly prohibited during breastfeeding. Ketorolac easily passes into breast milk and can cause significant harm to the health of a newborn baby.

Arketal Rompharm

Arektal Rompharm is a drug with an analgesic, antiphlogistic and fever-reducing effect.

The described drug is dispensed from pharmacies in the form of solutions for intramuscular and intravenous injections, 2 ml in each ampoule.

The composition of 1 milliliter of the drug includes:

• Ketoprofen – 50 mg;
• Additional components;

The product is recommended for therapeutic treatment and pain relief for the following diseases:

• Arthritis;
• Spondylitis;
• Osteoarthrosis.

Erectal Rompharm should not be used:

• For bleeding of any nature;
• For ulcerations of the stomach and intestines;
• With poor blood clotting;
• For bronchial asthma;
• In case of excessive sensitivity to the components of the described product;
• Up to 15 years of age.

According to the instructions, there may be side effects. Therefore, before use, it is imperative to consult a doctor.

Ketonal - analogues

Ketonal is often prescribed for pain relief, inflammation and fever. This drug is highly effective, bioavailable and fast-acting. But Ketonal is not suitable for all patients - analogues of the medication are recommended in cases of intolerance to this medication and the occurrence of allergic reactions after its use.

Analogues of Ketonal in capsules and tablets

The presented drug in tablet form is available in two dosages - 100 and 150 mg.

Analogues of Ketonal Duo and standard capsules:

• Flamax Forte;
• Ketoprofen and Ketoprofen MB;
• Flexen;
• Bystrumcaps;
• Profenid;
• Artrum;
• Oruvel;
• Ultrafastin.

Analogues of Ketonal in the form of cream and gel

This medication for topical use can be replaced with the following:

It is worth noting that all of the listed drugs identical to Ketonal have the same concentration of the active substance (ketoprofen) - 2.5%.

Analogues of Ketonal in the form of rectal suppositories

In the form of suppositories, the following analogues of the described drug can be purchased in the pharmacy chain:

As you can see, there are few medications identical to the medication in the form of rectal suppositories. Moreover, the listed analogs do not have such high bioavailability and effectiveness, begin to act much more slowly and require the use of large doses of ketoprofen. Therefore, doctors do not recommend replacing Ketonal suppositories. If they are intolerant, another medicine in the form of tablets, injection solution or gel is usually recommended.

Liquid analogues of Ketonal

The fastest way to relieve pain is an intramuscular injection, since the active substance immediately enters the circulatory system and reaches the source of inflammation. Because of this, there are the most synonyms of Ketonal in the form of an injection solution:

• Artrosilene;
• Flamax;
• OKI;
• Flexen;
• Oruvel;
• Arketal.

There is also a unique analogue of the drug used in medical institutions - V*Ergotex KF10001. It is available in the form of a powder, which is a concentrate of ketoprofen, and is considered more effective and biologically available than Ketonal.

More about contraindications

Not all patients can take this medicine. "Ketonal" has a number of contraindications, which you should definitely familiarize yourself with:

• pregnancy and lactation (you need to stop breastfeeding for the duration of therapy);
• children's age (the drug can be used to treat patients over 15 years of age);
• severe kidney disease, including renal failure;
• bleeding disorders, including hemophilia;
• liver failure;
• uncompensated heart failure;
• hypersensitivity to ketoprofen, salicylates and other non-steroidal anti-inflammatory drugs;
• bleeding, including gastrointestinal;
• postoperative period during coronary artery bypass grafting;
• chronic dyspepsia.

Negative reviews

But not all patients were satisfied with taking Ketonal DUO tablets. Some of them indicate in their negative reviews that the drug was not effective enough. It eliminates the pain, but after a few hours it returns again. And you can no longer take another capsule, since otherwise the patient will exceed the daily dosage. Therefore, people have to endure the pain and then switch to another effective remedy. In the reviews they indicate that instead of the promised 24 hours, the capsules only last about 5-7. Patients also write in reviews that after taking it they noticed a deterioration in their own well-being. Most often they suffer from nausea, headaches and abdominal discomfort. After finishing taking the capsules, these symptoms disappear. The high cost of the drug is another significant drawback. Because of this, some patients cannot afford to constantly use this painkiller. Therefore, they are forced to choose a more budget-friendly analogue. Doctors in the reviews note that the drug negatively affects the condition of the gastrointestinal tract, so it is still not worth using it for a long period. Otherwise, complications may occur.

This article discussed in detail the instructions for Ketonal DUO (150 mg). We can say that this is a modern drug that is highly effective. If you take it correctly, following your doctor’s recommendations, you can reduce the risk of side symptoms to a minimum.

Analogues of Ketonal capsules

Last price update: 10/01/2019 (150+ cities and 12,000+ pharmacies)

Source of information about drugs – RLS Directory of Medicines©

Purpose of the page: show a list of analogues (synonyms), current prices and drug ratings provided by users (over 10,000 ratings in total).

List of analogues: sorting by price, rating

Ketonal (capsules) Rating: 69

Cheaper substitutes for Ketonal

Flamax forte (tablets) Rating: 65 Top

Analogue is cheaper from 148 rubles.

Flamax Forte also belongs to non-steroidal anti-inflammatory drugs and has a similar list of indications. In this substitute, the dosage of ketoprofen is 2 times higher than the minimum in the “original” drug.

Ketoprofen (tablets) Rating: 61 Top

Analogue is cheaper from 130 rubles.

Ketoprofen is an inexpensive Russian drug with a similar active ingredient by name. Prescribed for the treatment of degenerative diseases of the musculoskeletal system (for example, arthritis, osteoarthritis). There are contraindications and side effects.

Analogue is cheaper from 87 rubles.

Flexen is an Italian-made substitute, which will also cost less than Ketonal. It contains the same active ingredients, so the indications for use do not differ significantly.

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The purpose (mission) of the site is to provide users with the most complete and up-to-date list of available analogues of drugs with prices in pharmacies and ratings for analogues (synonyms), which were set by the users themselves. Thus, the site analogist.ru can help you not only select cheaper analogues of drugs, but also show you the highest quality drugs according to site users.

The information published on the site is for informational purposes only and does not replace qualified medical care. Be sure to consult your doctor!

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Ketanov

Ketanov is a non-steroidal drug with the main substance in the form of ketorolac, which has an analgesic, fever-reducing and antiphlogistic effect.
Compared to narcotic analgesics, the described analogue of Ketonal does not have any negative effect on psychomotor functions and heart function, does not depress the respiratory center and does not cause addiction. Ketanov is dispensed from pharmacies in the form of ointment, solution and tablets.

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The tablet of the described product contains:

• Ketorolac (10 mg);
• Additional substances;

1 milliliter injection solution contains:

• Ketorolac (30 mg.);
• Additional substances;

The described medication in any form is used to relieve pain after any surgical intervention, as well as for injuries to bones, muscles and tissues.

Ketanov can help:

• For toothache;
• For pain symptoms in the kidneys and liver;
• For tissue pathologies of a permanent nature;

Instructions for use of the described product indicate one or another contraindication to the use of the drug in the form of:

• Hypersensitivity;
• Angioedema;
• Bronchospasm;
• Aspirin asthma;
• Dehydration;
• Hypovolemia.

Also, the medication is not indicated:

• For liver and kidney diseases;
• For disorders of the hematopoietic system;
• During pregnancy and childbirth;
• When breastfeeding;
• Up to 16 years of age.

Compared to the cost of the main drug, the price of the Ketonal analogue is significantly less. You can purchase the medicine in pharmacies at prices ranging from 23 to 57 rubles per pack.

Ketonal cream analogs

This page provides a list of all analogues of Ketonal cream according to composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Ketonal cream: Diclofenac
• The most popular analogue of Ketonal cream: Diclofenac
• ATC classification: Ketoprofen

When calculating the cost of cheap analogues of Ketonal cream, the minimum price was taken into account, which was found in the price lists provided by pharmacies

This list of drug analogues is based on statistics of the most requested drugs

All analogues of Ketonal cream

Analogues in composition and indications for use

The above list of drug analogues, which indicate substitutes for Ketonal cream , is the most suitable, since they have the same composition of active ingredients and coincide in indications for use

Analogues by indication and method of use

Different composition, may have the same indication and method of use

How to find a cheap analogue of an expensive medicine?

To find an inexpensive analogue of a medicine, a generic or a synonym, first of all we recommend paying attention to the composition, namely the same active ingredients and indications for use. The same active ingredients of a drug will indicate that the drug is a synonym for the drug, pharmaceutically equivalent or a pharmaceutical alternative. However, we should not forget about the inactive components of similar drugs, which may affect safety and effectiveness. Do not forget about the instructions of doctors; self-medication can harm your health, so always consult a doctor before using any medication.

Ketonal cream price

On the sites below you can find prices for Ketonal cream and find out about availability at a pharmacy near you

• Ketonal cream price in Russia
• Ketonal cream price in Ukraine
• Ketonal cream price in Kazakhstan

All information is presented for informational purposes and is not a reason for independent prescription or replacement of medication.

More contraindications

There are relative and even absolute contraindications for taking the drug Ketanov. Their list is quite large. If the patient has an absolute contraindication for taking Ketanov, then it should not be used under any circumstances, even with severe pain

If the patient has a pathology that is a relative contraindication for taking this analgesic, then it should be taken only under the close supervision of a doctor, with extreme caution

We present to you a list of pathological conditions and diseases for which Ketanov is absolutely contraindicated:

1. The patient has or had “aspirin asthma.”
2. Individual sensitivity has been discovered.
3. Angioedema.
4. Bronchospasm.
5. Dehydration.
6. A small volume of blood was detected.
7. Exacerbation of peptic ulcers is observed.
8. The patient has decreased blood clotting.
9. There is an exacerbation of gastrointestinal lesions.
10. Liver failure.
11. Renal failure (creatine concentration in the blood is greater than 50 ml/l).
12. Hemorrhagic diathesis.
13. Hemorrhagic stroke, even if it is only suspected.
14. Hematopoiesis is impaired.
15. There is a risk of bleeding.
16. Pregnancy.
17. Lactation.
18. Chronic pain.
19. Age less than 16 years.

Analogues of Ketonal capsules

Ketonal (capsules) Rating: 516

Ketonal is a capsulated drug that has analgesic, anti-inflammatory and antipyretic effects. The active ingredient is ketoprofen in a dosage of 50 mg. per one capsule.

Analogs of the drug Ketonal

Analogue is cheaper from 87 rubles.

Flexen is an Italian anti-inflammatory and antirheumatic drug with systemic action. Active ingredient: ketoprofen. Can be prescribed for arthritis, osteoarthritis, radiculitis, gout, bruises, dislocations and muscle strains.

Analogue is cheaper from 130 rubles.

Pharmstandard, Synthesis (Russia) Ibuprofen is a non-steroidal anti-inflammatory drug. It is produced in the form of tablets that contain 200 or 400 mg of the ibuprofen molecule. When released into the bloodstream, it has hypothermic, anti-inflammatory, analgesic, and antiplatelet effects. Arthritis, osteochondrosis, ankylosing spondylitis, neuralgic amyotrophy, diseases accompanied by inflammation and degeneration of the musculoskeletal system, pain syndrome of various localizations, adnexitis, elevated body temperature - indications for the use of Ibuprofen. Used from 200 mg 3-4 times a day, depending on the pathology and severity of symptoms. Use for bronchial asthma, blood clotting disorders, ulcerative lesions of the stomach and intestines is strictly prohibited. Undesirable manifestations may include dyspeptic symptoms, shortness of breath, ringing, tinnitus, blurred vision, headache, insomnia. In pediatrics, it is allowed from 3 months; for pregnant women, use in the first two trimesters under medical supervision is permissible.

Analogue is cheaper from 148 rubles.

Flamax Forte also belongs to non-steroidal anti-inflammatory drugs and has a similar list of indications. In this substitute, the dosage of ketoprofen is 2 times higher than the minimum in the “original” drug.

Ketonal (cream, gel, injections, tablets, suppositories), Ketonal Duo – price

Ketonal is a fairly common drug; it has many analogues, both with ketoprofen and with other active ingredients that perform all the necessary functions:

• relieve swelling of joints;
• normalize the production of collagen and elastin;
• improve intracellular metabolism;
• normalize the amount of synovial fluid.

These medications include the following:

• creams and balms based on glucosamine and chondroitin;
• Fastum gel;
• Shark cartilage;
• Arthrocol;
• Dexalgin;
• Joint;
• Sustavin;
• Sertofen;
• Bystrum gel;
• Espol ointment

Difference between Ketonal and Ketoprofen

Many people are interested in what is the difference between Ketonal and Ketoprofen. Let's look at the main similarities and differences. In both the first and second products, the active ingredient is ketoprofen. But in the cream there is a greater concentration of it, due to which it acts more actively and faster. Although it has more contraindications than Ketoprofen in a small concentration.

In conclusion, I would like to note that no one is immune from joint pain and diseases. Most often, changes in tissues occur with age, when the body wears out, all intracellular processes deteriorate and slow down. But it is possible that problems can also develop in young people as a result of some factors, for example, the consequences of injuries and fractures, or due to excessive physical exertion.

We invite you to read: Determined late pregnancy

Features of candle treatment

Suppositories, like tablets, have positive and negative features when used. For example, it is inconvenient to take suppositories at the right time, since at the appointed hour a man may find himself in a crowded place and there will not be a place where he could insert a suppository. Moreover, after administration it is better to stay in a horizontal position for a while.

The advantage of suppositories is that the active substances can quickly approach the prostate gland and begin their action. In order for the drug to get as close to the prostate as possible, a man should not immediately get out of bed after administration.

Using suppositories, you don’t have to worry about the negative consequences that appear when treating with pills.

Suppositories can be prescribed in both small and large dosages for prostatitis, since the active components of the drugs do not pass into the liver and do not remain there to disintegrate, like tablets. Suppositories do not have the ability to negatively affect the entire body, as happens when taking medications. They have the ability to not leave behind toxins that are harmful to the human body.

A minor disadvantage of suppositories is that a man has to prepare in advance for the procedure of administering the medicine in the form of a suppository. In addition, he will need to remain in bed for some time after inserting the candle.

How to treat an inflamed prostate gland is something everyone decides for themselves. You should not listen to the advice of friends and relatives; it is better to immediately turn to specialists. For example, Ketonal suppositories are recommended for those men who are not yet 55 years old. This is due to the fact that at a later age all of the listed contraindications begin to develop.

Pharmacokinetics

The instructions for “Ketonal DUO” (150 mg) also call this drug an improved version of conventional capsules. The main difference is the method of releasing the active substance from them. The improved capsules contain two types of pellets: standard white and yellow, coated with a special shell. The former release ketoprofen within a short period of time after taking the capsule. Yellow pellets begin to act only after some time. Thus, with their help, the drug remains effective for a long time. Therefore, these capsules can be taken only once a day so as not to feel pain.

The drug is well absorbed and has high bioavailability, approximately 90%. Eating may affect the rate of absorption of the drug, slowing it down. Accordingly, the capsules in this case will not act so quickly. The drug is excreted through the kidneys. They process approximately 90% of the active substance. Another 10% is excreted from the body through the intestines.

Symptoms and treatment of overdose

When taking more than 200 mg of the active substance per day, an overdose may occur. It can be identified by the corresponding symptoms that are characteristic of all NSAIDs. Patients begin to complain of severe nausea, which over time develops into vomiting. However, in especially severe cases it can be bloody. A person begins to experience severe stomach pain, and melena appears - unformed black stool with an unpleasant odor. If you do not seek help from a doctor in time, the symptoms begin to intensify. The patient is diagnosed with impaired consciousness and respiratory depression. Convulsions appear, and subsequently severe renal failure develops, since the organs cannot cope with the removal of large amounts of the active substance from the body.

The instructions for using Ketonal DUO tablets indicate that in case of an accidental overdose, it is necessary to immediately perform a gastric lavage and then give the patient activated charcoal to slow down the absorption of the drug. You should also seek help from a doctor. Specialists will prescribe symptomatic therapy to the patient, usually taking drugs that reduce the secretion of the stomach walls. When diagnosing kidney failure, it is necessary to perform hemodialysis to help the body remove ketoprofen from the body faster.

Ketoprofen

Ketoprofen is a fairly effective substitute for Ketonal with its inherent analgesic, fever-reducing, anti-exudative effect. The anti-inflammatory effect is achieved in the treatment of ailments such as arthritis, as well as diseases indicated by damage to the ligaments, tendons and muscles.

The described drug is produced as:

• Gel for external use;
• Ointment;
• Tablet form, where the main component and additives are Ketaprofen (150 mg), microcrystalline cellulose, povidan, colloidal silicon dioxide, magnesium stearate.

Ointment and gel are necessary if the patient has affected joints, inflamed lymph nodes, veins, tendons, ligaments and muscles. Similar external agents are also prescribed for joint swelling, muscle and ligament injuries, and post-traumatic swelling.

Ketoprofen is recommended by doctors for use for ailments in the form of:

• Arthritis;
• Rheumatic conditions;
• For inflammation of the tendons;
• For bursitis, tenosynovitis.

The analogue is contraindicated:

• In cases of kidney and liver dysfunction;
• People with stomach ulceration and hematopoietic disorders;
• For skin diseases;
• When carrying a child, especially in the 3rd trimester;
• When breastfeeding;
• In children up to 14 years of age.

Ketaprofen can only be taken under medical supervision for diseases such as bronchial asthma, cardiac disorders, arterial hypertension, and diabetic conditions. In addition, the course of treatment using the ointment and gel of the described product should not last more than 14 days.

Reviews

Evgeniya, 36 years old

I learned about Ketonal from a friend. One day I urgently needed to restore a damaged knee, and a friend advised me to buy Ketonal cream. The pain went away after just one use. Now all members of my family use this drug.

Valentina, 58 years old

I have been suffering from back pain for a long time. This prevented me from fully enjoying life and leading an active lifestyle. But thanks to Ketonal, I have long forgotten what a sore lower back is. I stopped resorting to drug treatment and now Ketonal is my constant companion.

Composition of Ketanov

Both Ketanov injections and other forms contain ketorolac. Ketanov for toothache tablets contain 10 mg. of this substance, and the injection form is 30 mg. in 1 ml. Ketanov tablets contain characteristic additional components that allow it to start working faster, maintain its properties and be effective:

• starch;
• silica;
• cellulose;
• magnesium stearate;
• macrogoals;
• talc.

Ketanov injections additionally contain sodium chloride, sodium edetate, sodium hydroxide, ethanol and water. Thanks to all this, Ketanov’s action occurs faster, and the analgesic effect is stronger.

Dosage form, composition, packaging

The active ingredient in Ketonal may reduce the effectiveness of blood pressure-lowering medications and enhance the effect of oral antihypoglycemia medications.

Combined use with other non-steroidal anti-inflammatory drugs, salicylates or alcohol increases the risk of complications of gastrointestinal diseases.

Medicines such as Actelise, Reteplase, drugs to reduce blood clotting: Phenylin, Warfarin Nycomed and medications for the treatment of peripheral circulatory disorders can cause bleeding.

The product is available in the form of rectal suppositories. Externally they are bullet-shaped, white, uniform in consistency, smooth.

Each suppository includes a medicinal substance - ketoprofen 100 mg and additional components to facilitate the administration procedure: solid fat, glyceryl caprylocaprate.

Ketonal suppositories are contained in a cardboard package with two foil strips of 6 suppositories each.

There are different forms of release of Ketonal:

• in the form of tablets of 100 and 150 mg;
• capsules 50 mg;
• in ampoules for intravenous and intramuscular injections of 50 mg/ml - 2.0 ml;
• in the form of a patch;
• in the form of a cream for external use.

Warming patchCapsulesCreamAmpoules for injectionRectal suppositoriesTablets

The main component of the drug weakens the effectiveness of antihypertensive drugs and diuretics, and increases the effectiveness of hypoglycemic drugs (oral administration), as well as some medications that relieve seizures (for example, phenytoin).

The likelihood of gastrointestinal diseases increases significantly when taking other NSAIDs, salicylates, ethyl alcohol and corticosteroids in parallel.

The likelihood of bleeding increases when the drug is used together with antiplatelet agents, thrombolytics and anticoagulants.

Concomitant use of the drug with ACE inhibitors and diuretics may lead to a risk of deterioration of kidney function.

Joint use leads to an increase in the amount in the blood of medications such as cyclosporine, calcium channel blockers, methotrexate, drugs with lithium, cardiac glycosides.

Ketoprofen can reduce the effect of mifepristone. Therefore, medication treatment should be started no earlier than 12 days after the end of mifepristone use.

The likelihood of bleeding increases when combined with pentoxifylline. This combination requires frequent monitoring of clinical parameters.

Concomitant use of probenecid may reduce the rate of clearance of the main component of the drug, ketoprofen.

What to pay attention to when reading the instructions

The instructions are quite accessible and describe in detail the indications and contraindications for the use of Ketanov, recommended doses, treatment regimen and possible side effects. Be sure to read the instructions before using this drug! This will protect you from possible mistakes in its use, as well as from overdose. The instructions describe in detail about Ketanov injections and tablets: what they are for, what treatment regimen and dosage should be followed. As we have already mentioned, the drug is offered in the form of tablets or solution. For most patients, the most convenient form of this medication is tablets. The instructions indicate that they should be taken orally and swallowed whole. You should not bite them or chew them. It’s not without reason that the manufacturers hid the active ingredient of the drug behind the shell. This reduces its negative impact on the gastric mucosa. During administration, the tablet should be taken with water. There should be a little water, but not less than 100 ml. To prevent negative effects on the mucous membranes, take the drug after meals. But keep in mind that if you ate something very fatty or had too much food before taking the pill, the effect of taking it will come a little later.

There are times when pain needs to be relieved as soon as possible. Then the tablet can be taken before meals. Ketanov should be used when pain really bothers you and exhausts you. In some cases, for example, after a serious injury or surgery, Ketanov is taken according to the schedule. In this case, you need to drink it even when there is no pain. If you drink Ketanov in order to overcome sudden pain, then take only one tablet. Before doing this, you should definitely consult a doctor, as there are a number of pathologies in which it can be dangerous. If you take the drug according to the schedule prescribed by the doctor, then you will most likely need to take 1 tablet 3-4 times a day at regular intervals. It also happens that a person suffers from severe unbearable pain. Then it is permissible to increase the dosage to 2 tablets 3-4 times per day.

Also in some cases you should take half the dose (half a tablet), namely if:

1. You weigh less than 50 kg.
2. You are over 65 years old.

Continuous use of Ketanov should not exceed 5 days. In some rare cases, taking the drug for a week is allowed. If you take it longer, the risk of serious and even dangerous side effects will increase significantly. Ketanov injections are also allowed for deep intramuscular injection. In this case, the doctor will try to select a minimal but effective dose. In doing so, he must take into account your age, weight, concomitant diseases, nature and cause of pain. He should continually monitor your response to treatment. In severe cases, opioid analgesics are used along with Ketanov. Any form of Ketanov is used for a maximum of 5 days.

Reviews about Ketonal Duo

A variety of dosage forms (capsules, ampoules, suppositories, retard tablets, forte) allows you to choose the most effective route of administration and select an adequate dosage.

Ketoprofen is an effective remedy for the treatment of pain (postoperative and oncological), as evidenced by reviews of Ketonal Duo capsules. In oncology, it is highly effective in relieving pain that accompanies bone metastases. It is often used to relieve an acute attack of migraine, various diseases of the musculoskeletal system, and algodismenorrhea. In general, Ketonal Duo was well tolerated; side effects occurred with long-term use. The most common symptoms were diarrhea, abdominal pain, exacerbation of peptic ulcer disease and chronic colitis.

Drug Ketonal

Ketonal suppositories are an anti-inflammatory agent that has analgesic, antipyretic and antiaggregation effects. In addition, “Ketonal” stabilizes the functioning of lysosomal membranes in chronic inflammation, prevents tissue destruction, helps increase range of motion, and reduces stiffness and swelling of joints. The Ketonal rectal suppository contains ketoprofen as an active ingredient. The main indications for the use of the drug "Ketonal" are various inflammatory, metabolic and inflammatory-degenerative diseases:

• psoriatic arthritis;
• osteoarthritis;
• rheumatoid arthritis;
• gouty arthritis;
• ankylosing spondylitis;
• bursitis;
• tenosynovitis;
• tendinitis;
• capsulitis.

"Ketonal" is an effective drug that has a quick effect, but you should not self-medicate. Long-term use of a rectal suppository can cause the development of ulcers in the rectum. The simultaneous use of pharmaceuticals based on an identical active ingredient will certainly lead to an overdose and side effects. In this case, the symptoms will correspond precisely to increased doses of the drug. It is necessary to eliminate unwanted manifestations only under the supervision of a doctor and according to individual recommendations. When using suppositories, children may experience the following symptoms:

• vomit;
• dizziness;
• nausea;
• diarrhea;
• swelling;
• itching

If the patient is already prescribed any medications, the use of Ketonal rectal suppositories can cause serious negative consequences, so they can only be used as prescribed by a doctor.