“Phlebodia 600 – a drug for the treatment of chronic venous insufficiency”

Category: Published 04/05/2017 · Comments: · Reading time: 5 min · Views: 3,553

A pharmacological agent belonging to the subgroup of angioprotectors is Phlebodia 600 tablets. What is the drug prescribed for? The product helps strengthen and protect vascular structures from injury. The instructions for use recommend taking the medicine “Phlebodia” for venous insufficiency. It has proven itself excellent in the practice of phlebologists and surgeons.

Phlebodia tablets

The drug is one of the angioprotectors. The medicine is used to treat vein diseases. The active ingredient of the drug helps improve blood microcirculation and helps restore blood vessels that have lost their tone . According to the instructions for use, Phlebodia tablets are mainly used for the treatment of hemorrhoids and varicose veins of the lower extremities, but are also used for a number of other negative conditions associated with disturbances in the circulation of biological fluids (blood, lymph) in the body.

Compound

The drug Phlebodia is available in tablet form. Moreover, one package contains 15 pills. The active component of the medicinal formula is granulated diosmin, a flavone-like pigment that is obtained from plants of the rue family. One tablet contains 600 mg of pure substance. Among the auxiliary components, the manufacturer in the instructions for use indicates cellulose, stearic acid, red cochineal and other components. You can find out about the mass fraction of each of the mentioned substances in the angioprotector from the table below:

pharmachologic effect

The therapeutic effect is achieved 60 minutes after taking the medication. In this case, the therapeutic effect of the angioprotector lasts for 96 hours. The active components of the drug easily penetrate even the smallest subcutaneous veins of the lower extremities, lungs, kidneys and selectively accumulate in damaged vascular walls. The therapeutic and restorative effect of the drug Phlebodia is largely determined by the properties of its active substance - diosmin. This flavonoid has the following pharmacological effects:

• increases vein tone;
• has an anti-inflammatory effect;
• fights excessive permeability of lymphatic capillaries;
• prevents the appearance of trophic ulcers;
• has a vasoconstrictor effect;
• prevents bleeding;
• stimulates skin circulation;
• stimulates the circulation of biological fluid in the lymphatic vessels.

Indications for use

Phlebodia tablets for varicose veins effectively act on venous vessels, thereby preventing their excessive expansion under the influence of high blood pressure. The substance diosmin, as an active component of the drug, improves microcirculation of biological fluids, eliminates swelling and pain. As part of complex therapy for venous insufficiency, the medication is used to quickly get rid of the manifestations of acute hemorrhoids or symptoms of varicose veins of the legs. In addition, according to the instructions, the drug is recommended for use for the following vascular problems:

• increased capillary fragility;
• acute uncomplicated hemorrhoids;
• lymphovenous insufficiency;
• after phlebectomy as a prophylaxis for varicose veins;
• violation of venous microcirculation;
• after removal of intrauterine devices to prevent bleeding.

Release form, composition and packaging

Tablets, film-coated, pink, round, biconvex.

Excipients: talc, colloidal silicon dioxide, stearic acid, microcrystalline cellulose.

Film shell composition: Sepifilm 002 (hypromellose (E464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg); Sepispers AP 5523 pink (propylene glycol - traces, hypromellose (E464) - 0.458 mg, titanium dioxide (E171) - 4.026 mg, crimson dye (Ponceau 4R) (E124) - 0.401 mg, iron oxide black (E172) - 0.130 mg, iron red oxide (E172) - 0.020 mg); Opaglos 6000 (carnauba wax (E903) - 0.075 mg, beeswax (E901) - 0.075 mg, shellac (E904) - 0.150 mg, ethanol 95% - traces).

15 pcs. - blisters (1) - cardboard packs. 15 pcs. - blisters (2) - cardboard packs.

How to take Phlebodia

The instructions for use of the drug indicate that it should be taken orally. The drug is quickly absorbed from the gastrointestinal tract. Excretion of the active components of the drug occurs mainly by the kidneys. Up to 11% of ingested diosmin is excreted from the body with bile and feces. The treatment regimen is prescribed individually to each patient, taking into account the pathophysiological stage of a particular disease .

In a situation where Phlebodia 600 is used for the treatment of varicose veins or chronic venous insufficiency of the lower extremities, the recommended daily dose of the medication is 1 tablet. The duration of treatment is a month. The presence of trophic ulcers requires a longer course of treatment (about six months). If the symptoms of hemorrhoids worsen, the instructions for use recommend taking 2-3 tablets of the drug per day for a week.

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Contraindications and side effects.

Contraindications to the use of Phlebodia 600 include:

• excessive sensitivity to the components of the drug;
• lactation period;
• age less than 18 years;
• the first three months of pregnancy.

In the early stages of pregnancy, it is contraindicated to take Phlebodia 600

When the drug was used by women during pregnancy in the second or third trimester, no side effects were observed. However, the drug can only be used as prescribed by a specialist, since this action poses a certain risk for the child.

No symptoms associated with overdose or concomitant use of the drug with other drugs were identified. There was also no effect of the drug on the ability to drive a car or other vehicle.

Phlebodia during pregnancy

In the course of large-scale clinical studies, it was proven that the medication does not have a teratogenic (harmful) effect on the body of the mother and fetus. However, in order to avoid undesirable consequences (accidental involution), an angioprotector is prescribed only from the second trimester of pregnancy. Reviews from expectant mothers about the use of the drug indicate its extremely positive effect on the body.

Pharmacokinetics

Suction

Rapidly absorbed from the gastrointestinal tract, detected in plasma 2 hours after administration. Cmax in blood plasma is achieved 5 hours after administration.

Distribution

It is evenly distributed and accumulates in all layers of the wall of the vena cava and saphenous veins of the lower extremities, and to a lesser extent in the veins of the kidneys, liver, lungs and other tissues. Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum 9 hours after administration and persists for 96 hours.

Removal

Excreted in urine - 79%, in feces - 11%, in bile - 2.4%.

Phlebodia's analogs

Angioprotectors constitute a large group of medications aimed at strengthening the walls of the micro- and macrovasculature. The range of applications of Phlebodia analogues is largely similar, which cannot be said about their cost. The significant difference in price is due to the use of unique technologies for the production processing of diosmin by some pharmaceutical companies. Thus, among modern drugs created using the most modern equipment, the following effective analogues of Phlebodia can be distinguished:

• Vasocket;
• Diosmin;
• Venarus;
• Detralex;
• Diovenor.

pharmachologic effect

Angioprotective drug. It has a venotonic effect (reduces the distensibility of veins, increases their tone / dose-dependent effect /, reduces venous stagnation), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance / dose-dependent effect/, reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Strengthens the vasoconstrictor effect of epinephrine (adrenaline), norepinephrine (norepinephrine), blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Price Phlebodia

The drug is sold in packages of 15, 30 and 60 tablets. As with any other medicine, it is more profitable for financial reasons to buy several blisters at once. Moreover, this is also advisable from the point of view of following the doctor’s recommendations. For these reasons, it is better to purchase the medicine for the entire course. You can roughly estimate the cost of treatment by reading the metropolitan prices for the drug shown in the table below:

Is it possible to completely cure the pathology?

Almost all patients, taking this medicine, hope to eliminate the pathology completely. They want to get rid of not only unpleasant symptoms, but also eliminate varicose veins, hemorrhoids, ulcers, and so on. Is this really possible? What do doctors say about this?

Doctors say that the drug is an excellent preventive measure. It is very effective in the early stage of the disease. In such a situation, the tablets quickly relieve disturbing symptoms and prevent the expansion of venous blood flow. The composition also eliminates hemorrhoids well, preventing its further progression. It is worth noting that simultaneously with such a correction, nutrition should be normalized.

Despite all the positive qualities, the drug cannot completely eliminate already dilated veins. This is exactly what all phlebologists and vascular surgeons confirm. If there is a malfunction of the valves, then only surgery can help fix the problem. The use of the drug described above only helps to relieve signs of pathology. Regular use of the prescribed courses prevents possible problems.

Compound

The medicine Phlebodia 600 looks like round pink tablets with a gray-brown core. Their composition:

• active ingredient: granulated diosmin (600 mg per piece);
• auxiliary ingredients: opagloss (palm, beeswax, gum lac, ethanol), talc, red cochineal, black and red iron oxides, propylene glycol, titanium dioxide, stearic acid, silicon dioxide, microcrystalline cellulose;
• composition of the protective film: hypromellose, polyethylene glycol stearate, microcrystalline cellulose.

Which is better – Curantil or Trombo ACC?

Both drugs are most often prescribed during pregnancy; they are analogues in relation to each other.

Curantil is prescribed to improve blood circulation, starting from the 2nd trimester of pregnancy. Before pregnancy, when planning, use Thrombo ACC.

The reason for prescribing these drugs may be hereditary thrombophilia or indications of blood tests (coagulogram, etc.), by which a hematologist or gynecologist determines the risk of blood clots in a pregnant woman.

In this case, the drugs can be prescribed simultaneously.

Thrombo Ass contains acetylsalicylic acid and costs from 40 rubles, and Curantyl contains Dipyridamole, and its price in pharmacies starts from 520 rubles. The difference in cost, as you can see, is quite large. Therefore, if you need a budget product, it is better to choose Trombo ACC.

Which one is better is decided strictly individually for each patient, depending on the purpose of treatment and indications.

Operation shown

For LVN, surgical intervention is possible. During the event, diseased venous areas are removed and angioplasty is performed. It is possible to install prostheses when the doctor creates an artificial vein. Another option is bypass surgery. During the work, the surgeon uses other vessels of the patient’s lower extremities.

If the disease is severe, the patient is seen by the doctor at the last stage, there is a risk of gangrene, and amputation of the limbs is required. To minimize the likelihood of such consequences, it is necessary to consult a doctor in a timely manner as soon as suspicion of LVN arises.

What is the benefit of the drug

Phlebodia 600 is a venotonic tablet from France. The active substance of the drug is diosmin. Thanks to him:

• the tone of the veins increases, stagnant formations in them are eliminated;
• blood microcirculation in the capillaries is restored;
• the permeability of the venous walls decreases;
• blood supply to the skin improves;
• lymph outflow returns to normal;
• inflammation decreases.

Phlebodia 600 - venotonic drug from France

Venotonic in the early weeks and later

In the first trimester, the medicine is contraindicated due to the lack of experience in its use in the early stages of pregnancy. After 12 weeks it can be used as prescribed by a doctor. Experimental studies of Phlebodia 600 were carried out, which did not reveal any disturbances in the development of the embryo under the influence of the drug. Data obtained in clinical practice also indicate the absence of a negative effect on the course of pregnancy and fetal formation.

Precautionary measures

Phlebodia, like any medication, has a list of contraindications:

• Intolerance to the components of the drug.
• During pregnancy (up to 13 weeks) and lactation.
• Patients under 18 years of age.

If the rules of administration are violated or there is hypersensitivity to the components of the venotonic, negative reactions occur:

• nausea, burning sensation in the chest, pain in the abdomen;
• headache.

If such symptoms appear, stop taking the drug and consult a phlebologist. There is no information on drug overdose. Phlebodia is allowed to be taken before activities that require increased attention.

If during the treatment of hemorrhoids there is no rapid therapeutic effect, then you need to inform your doctor. The doctor will conduct an additional examination and select a different treatment tactic.

Additional methods

You can stimulate blood flow at the capillary level and prevent the formation of blood clots by using plants that contain salicylates and coumarins in different parts - their effectiveness is to some extent similar to acetylsalicylic acid, but the effect is milder, and the risk of side effects is lower. Such medicines include basil and peony, raspberries and sweet clover. Decoctions with meadowsweet and toadflax will benefit the sick.

All of these plants have an anti-inflammatory effect, although some have a stronger effect.

To stop the activity of foci of inflammation, you should pay attention to the possibility of using buckthorn, bergenia, and oak bark. These plants are rich in gallic acid, tannins, that is, substances that inhibit inflammation.

You should not expect that such folk remedies will become effective substitutes for ointments, gels and tablets. To prevent LVI from developing into a more severe form, it is necessary to strictly follow the therapeutic program recommended by the doctor and use the patented medications prescribed by him. For example, such as Phlebodia 600. According to reviews, this drug is quite effective. It eliminates not only symptoms, but also affects blood vessels, improving them. This remedy has helped many patients cope with the acute stages of the disease.

Instructions for use of the medication and its analogues

The drug is prescribed according to a specific regimen. It all depends on the stage of the disease and the symptoms that appear.

To treat venous insufficiency, the medicine is prescribed one capsule daily. The course of such correction is two months. After surgical interventions, a similar dosage regimen is chosen.

In severe forms of pathology and severe symptoms, the medication is prescribed for six months. In this case, the patient should consume 600 milligrams of diosmin per day. This amount of substance is equal to one tablet.

When treating hemorrhoids of external and internal localization, the drug is prescribed for a period of one week. In this case, in the first three days you need to take up to four capsules of the medicine. After this, the dosage is reduced to two tablets. If necessary, you can continue taking it for up to one month.

Analogues of the described drug are used in slightly different schemes. From one to seven tablets can be prescribed per day. It all depends on the pathology and the chosen medication.

Features of application

The tablets should be taken before or during meals. This will reduce the risk of side effects. To increase the effectiveness of the drug, additional treatment methods must be used. For example, if you have varicose veins, wear compression garments, give up tight shoes, and stand less. If you have hemorrhoids, do not lift heavy objects and avoid constipation. And to prevent edema, do not drink a lot of fluids at night, do not eat salty foods, and avoid stuffy rooms.

Often, Phlebodia tablets are prescribed together with Curantil during pregnancy. This treatment is very effective when there is a risk of developing fetoplacental insufficiency. These drugs complement and enhance each other's effects, thinning the blood and strengthening the walls of blood vessels. When used together, blood circulation improves and the supply of oxygen and nutrients to the fetus is normalized, the risk of developing blood clots is reduced and excess fluid is removed from the body faster.

What's better

The difference between medications of similar action and composition can be large.

To make an error-free choice, you have to answer a number of questions:

• what the drug contains in addition to the active substance;
• how to take the chosen medicine;
• what price will you have to pay for the medicine at the pharmacy.

The instructions that come with all medications help to understand this partly, but it is better to have an accurate idea of ​​how a particular drug works.

Phlebopha or Phlebodia?

It should be taken several times a day before or after meals, and the maximum daily dose cannot exceed 1800 mg.

Phlebofa is more expensive than Phlebodia 600

According to research results, it was revealed that, unlike Phlebodia, Phlebopha does not have a negative effect on the child that a woman is carrying, so this remedy can be taken without fear during pregnancy.

However, during lactation it is recommended to refrain from using Phlebof.

Detralex or Phlebodia 600?

In general, the effect obtained from taking Detralex and Phlebodia 600 is very similar, so the priority of one of these drugs is determined by the individual needs of the patient.

The cost of these drugs, when purchasing a package of 30 tablets, differs little, so this parameter can not be taken into account when comparing.

Troxevasin and Phlebodia?

Troxevasin (in tablet form) is degraded primarily in the liver. Then, along with bile and urine, it is excreted from the body. Phlebodia puts a similar load on the kidneys. Therefore, here you need to decide which organ is healthier and able to withstand treatment with such drugs.

Troxevasin puts stress on the liver

The presence of kidney failure makes it impossible to take both medications. Also, Troxevasin is not suitable for people suffering from stomach and intestinal ulcers.

The only group of patients for whom the use of Troxevasin will definitely be preferable are allergy sufferers. In addition, it is prescribed not from the age of 18, but from the age of 15.

How to replace the drug

Phlebodia 600 is a rather expensive medicine. On the Russian pharmaceutical market you can find both foreign and domestic complete analogues, which are cheaper:

• Vasocket;
• Venolek;
• Phlebofa;
• Diosmin.

Their composition and functions are identical. True, some diosmin analogues contain less (500 mg). Phlebodia is produced in Latvia in the form of a cream-gel.

Phlebodia cream-gel is applied directly to the legs and eliminates heaviness in them

The most famous analogue of the drug Phlebodia 600 is Detralex. This product contains both diosmin and hesperidin. The manufacturer claims that the medicine is produced using a special technology in which the raw materials are subjected to additional grinding (micronization). It is believed that in this form the active substance is better absorbed in the gastrointestinal tract. Detralex is available in the form of tablets and suspension. According to marketing research, in the summer months this drug is the best-selling medicine in Russia. Its complete analogue of Russian production is Venarus.

If a pregnant woman does not tolerate diosmin-containing drugs well, they can be replaced with Troxerutin or Troxevasin. Their active ingredient is troxerutin, which increases the density of the vascular wall, relieves inflammation, and reduces capillary fragility. The products can be purchased at pharmacies both in the form of capsules and in the form of ointments, creams and gels.

Objective comparative studies of the above analogues have not been conducted. Some doctors prefer to prescribe more modern angioprotectors: Phlebodia 600 and Detralex. Another part notes that products based on troxerutin are almost as effective as they are, but are much cheaper.

Table: Phlebodia 600 and analogues

Photo: replacement options for Phlebodia 600

Vasocket is produced in Germany and is a complete analogue of Phlebodia 600

One tablet of Venolek contains 500 mg of diosmin

Phlebofa is a complete analogue of Russian-made Phlebodia 600

One package of Diosmin contains 30 tablets

Detralex is the most popular diosmin-based drug

Venarus is a complete analogue of Detralex

Troxerutin capsules can be prescribed to a pregnant woman in case of intolerance to diosmin-containing drugs

Troxevasin is the most famous medicinal brand, the active ingredient of which is troxerutin.