Effect on the body
Nolpaza is a proton pump inhibitor.
Its action is based on blocking the synthesis of hydrochloric acid in the final stage, reducing and stabilizing total acidity in the stomach, helping in the treatment of inflammatory processes in the digestive tract. Pantoprazole in the drug reduces the release of acid within 60 - 100 minutes after administration, while achieving the maximum therapeutic effect. The substance does not affect the motility of the digestive process in the stomach and the intensity of intestinal motility.
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Next, absorption occurs through the intestinal mucosa and metabolism in the liver. The drug is excreted in the urine, and the remainder is excreted in bile. The activity of gastric secretion will be restored three to four days after the last use of the tablet.
Salts are almost not absorbed from the gastrointestinal tract, but are excreted along with feces. The remaining percentage of bismuth is excreted by the kidneys in the urine.
Characteristics of De-Nola
This is an antiulcer agent that has a bactericidal effect. It is presented in the form of tablets, the main component is bismuth. The drug is characterized by astringent and anti-inflammatory properties. When the medication enters the stomach, it creates a protective film on its surface.
To get rid of gastritis or stomach ulcers, doctors often prescribe various medications. This could be De-Nol and Nolpaza.
Indications for use:
- stomach and duodenal ulcers;
- gastroduodenitis;
- gastritis;
- irritable bowel syndrome;
- dyspepsia.
Duration of therapy is 4-8 weeks. Over the next 8 weeks, it is prohibited to use medications that contain bismuth. To get rid of Helicobacter pylori, it is recommended to take the medicine together with antibiotics that have an anti-Helicobacter effect. The medication should not be used for longer than 8 weeks. During therapy, stool may turn black. Sometimes there is a slight darkening of the tongue.
Joint effect
Often Nolpaza and De-Nol are prescribed simultaneously. The first drug stops the production of hydrochloric acid. The second medication has antibacterial and antiulcer effects.
But you need to take them together with caution. This is explained by the fact that De-Nol promotes envelopment of the mucous membrane, thereby creating a protective film. It protects the walls of the stomach and intestines from negative effects. But it also makes it difficult to absorb nutrients from other medications.
Prescription of drugs
De-Nol is prescribed when a patient has:
- ulcers in the stomach, duodenum;
- irritable bowel syndrome, which is accompanied by loose stools;
- dyspepsia not associated with organic gastrointestinal diseases;
- chronic gastritis and gastroduodenitis during exacerbation, associated with a high content of Helicobacter pylori.
Nolpaza is used for the following diseases:
- peptic ulcer of the duodenum, stomach;
- Zollinger-Ellison syndrome, accompanied by increased production of gastric secretions;
- GERD (gastroesophageal reflux disease), in the presence of pain in the esophagus, acid belching, heartburn in the stomach;
- in combination with two antibiotics to destroy bacteria in the walls of the stomach Helicobacter pylori;
- different forms of reflux - esophagitis;
- inflammation and ulcerative conditions of the gastrointestinal tract caused by long-term use of non-steroidal anti-inflammatory drugs.
In addition, Nolpaza can be used for a long time as a prophylactic against gastric and duodenal ulcers. The drug is able to stabilize the level of acidity in the stomach.
When taking both medications, the duration of the course of therapy and dosage are prescribed by the doctor after consultation and a complete examination of the gastrointestinal tract.
Action of Nolpaza
This is a hypoacid drug classified as a proton pump inhibitor. Available in tablet form.
When using the medicine, the secretion of gastrin increases. The medication is administered orally and it quickly enters the bloodstream. For patients with liver dysfunction, the dosage must be adjusted.
Indications for use:
- peptic ulcer of the stomach and duodenum;
- reflux esophagitis;
- identification of Helicorbacter pylori;
- conditions that provoke hypersecretion.
Caution when taking the medication should be exercised by patients who have a high risk of developing hypovitaminosis B12, and those who are at risk of developing gastrointestinal bleeding and ulcers. No cases of overdose were identified.
Caution when taking Nolpapza should be exercised by patients who have a high risk of developing hypovitaminosis B12.
Evgeniy, 55 years old, gastroenterologist, Moscow: “De-Nol is an effective remedy that I often prescribe for the treatment of gastrointestinal ulcers. Envelops the stomach with a protective film and has an antibacterial effect on Helicobacter pylori. Often leads to constipation, which should be taken into account by older patients.”
Mikhail, 52 years old, gastroenterologist, Samara: “Nolpaza is a proton pump blocker that helps protect the stomach during treatment with glucocorticoids and NSAIDs. Thanks to the drug, the development of pain, heartburn, ulcers, and gastritis is prevented. In some cases, it causes negative reactions in the body.”
How to take medicine correctly
- If Nolpaza is prescribed, it is drunk before meals once a day or twice, depending on the type of disease and the indicated dosage, on average 20–80 mg of pantoprazole (1–2 tablets at a time) per day. A detailed list of diseases and medications for them can be read in the instructions.
- The tablet should not be chewed so that the active substance does not damage the mucous membrane of the oral cavity and esophagus, but begins to exert its effect inside the body. It should be swallowed whole and washed down with plenty of drinking water.
- Depending on the form of the disease, taking Nolpaza can be seven days, a month, two or more.
De-Nol is taken twice a day, two tablets or one tablet 4 times a day. The drug is drunk half an hour before meals, washed down with plain water. The course of treatment usually lasts a month or two. It is not recommended to take the drug for a longer period; it is forbidden to increase the daily dose of tablets.
An overdose may cause poisoning of the body. To eliminate it, rinse the stomach and give the victim activated charcoal and a laxative. Then continue treatment based on symptoms.
Nolpaza is taken in the morning on an empty stomach, 1 tablet. De-Nol is taken 4 times a day, with 3 tablets taken during the day after meals, and the last one before bed.
De-Nol is taken 4 times a day, with 3 tablets taken during the day after meals, and the last one before bed.
Sanpraz
Pantoprazole in tablets and solutions for intravenous administration, manufacturer – India. A proton pump inhibitor that helps reduce the concentration of gastric juice. The product blocks the production of hydrochloric acid at the end of the process, reduces secretion, stimulated and basal. Sanpraz treats internal bleeding of the gastrointestinal tract and stress and acute peptic ulcers, erosive gastritis. The action of the medicine completely coincides with the action of nolpaza.
Contraindications for use are children and adolescents under eighteen years of age, oncological diseases of the gastrointestinal tract, allergies and sensitivity to elements of the substance.
Doctors prescribe one tablet once a day. No dosage adjustments should be made for patients with renal impairment or the elderly. A larger dose of Sanpraz is prescribed and monitored by the doctor, depending on the type and severity of the disease.
To prevent the disease, you should take half a tablet in the morning for a month. The solution is administered using a dropper or jet method, using one bottle per day (contains 40 ml of active substance).
Does not combine with iron salts or ketoconazole. Has side effects. While taking the medicine, the patient may experience dizziness, disorientation, thrombophlebitis, nephritis, arthralgia; dry mucous membranes, diarrhea or constipation. The development of allergic reactions of the body is possible.
Contraindications to De-Nol and Nolpaza
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De-Nol and Nolpaza are contraindicated during pregnancy and breastfeeding. Nolpaza can be prescribed by a doctor if necessary and under supervision to a nursing woman, and the baby should be weaned from the breast and transferred to artificial nutrition for the duration of treatment.
Both drugs cannot be prescribed to patients with impaired renal function and individual intolerance to the drug or one of its components.
Nolpaza has an additional range of contraindications:
- Children and adolescents should not be prescribed medicine if they are under eighteen years of age;
- patients with liver failure should take the tablets with constant monitoring of liver enzyme levels to avoid cirrhosis or liver failure;
- for stomach and intestinal disorders that arise against the background of neuroses;
- people who have problems absorbing vitamin B12;
- patients with hereditary fructose intolerance.
In the presence of malignant oncological formations, a full examination should first be carried out to identify the cause of the disease and establish the correct diagnosis. The medicine can mask the underlying disease and its symptoms.
Contraindications for the use of De-Nol include:
- severe impairment of kidney function;
- intolerance to the components of the drug;
- pregnancy;
- lactation period.
Contraindications to the use of Nolpaza:
- intolerance to the components of the product;
- neurotic dyspepsia;
- severe liver or kidney disease.
Adverse reactions
Common undesirable effects for both drugs: nausea, vomiting, constipation, allergic reactions in which there is a rash on the body and itchy skin.
Taking De-Nol in large quantities and for a long period, you can get encephalopathy - the accumulation of bismuth in the central nervous system.
In rare cases, Nolpaza may cause other undesirable effects:
- blurred vision and dizziness can be caused by the central nervous system;
- a decrease in the number of leukocytes can develop leukopenia, and platelets - thrombocytopenia;
- pain in the muscles and joints, leading to the appearance of myalgia and arthralgia;
- Inflammation of the renal tubules in the genitourinary tract, leading to kidney failure.
A severe allergic reaction to Nolpaza may manifest as Lyell's syndrome with a blistering rash all over the body or Stevens-Johnson syndrome with a regular rash.
During treatment with De-Nol, side effects may develop such as:
- constipation, diarrhea, nausea, vomiting;
- itching, skin rash;
- encephalopathy.
Side effects that may occur during Nolpaza therapy:
- increased concentration of liver enzymes, nausea, flatulence, gastralgia, stool disorders;
- jaundice;
- blurred vision, headache, dizziness;
- urticaria, skin rash, itching, Quincke's edema;
- hypertriglyceridemia;
- increased body temperature, muscle pain.
Taking Rabeprazole
Rabeprazole is a Russian-made proton pump blocker. The active substance is rabeprazole sodium. Available in 10 mg capsules. The drug is completely absorbed after 3.5 hours. The intake does not depend on food; De-Nol and Rabeprazole in the regimen do not interfere with each other. The Indian analogue based on rabeprazole is Khairabezol.
May have side effects:
- decreased appetite, nausea, vomiting, persistent diarrhea or constipation,
- stomatitis,
- bloating,
- dizziness with headache,
- lethargy, drowsiness,
- disturbance of taste and vision,
- temperature increase,
- pain in the back, muscles, joints,
- runny nose, cough, sinusitis,
- allergic skin rash.
Blood tests reveal: increased liver tests, leukopenia, thrombocytopenia. The drug is not used to treat children due to the lack of reliable research results.
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Difference between drugs
The drugs have different compositions and have different types of effects on the body. Nolpaza reduces gastric secretion, acting as a pump, due to which the level of hydrochloric acid in the stomach necessary for the healing of the mucous membranes is achieved.
De-Nol envelops the surface of inflamed areas and ulcers with a protective film, preventing hydrochloric acid from penetrating inside, helping to speed up the healing process. The effects of drugs are interrelated, so they can be prescribed in complex therapy.
Nolpaza
A synthetic mono-drug with the active ingredient – pantoprazole.
Enteric-coated tablets contain a number of auxiliary elements. Their set consists of mannitol, sorbitol, anhydrous sodium carbonate, crospovidone and calcium stearate. Drugs of this type are used for the treatment and prevention of all types of ulcers in the gastrointestinal tract.
- The drugs are prescribed to reduce the number of Helicobacter pylori bacteria, for inflammatory and ulcerative diseases of the gastrointestinal tract.
- Children under 12 years of age should not be given the medications in question.
- In some cases, drugs have the same contraindications for use and side effects on the body.
