The main task of Hofitol is to cleanse the liver of decay products and establish its normal functioning. The drug contains only natural ingredients, namely artichoke extract. Produced at the plant of a French pharmaceutical company. At the same time, you can find cheap, similar means for restoring liver cells. Next, we’ll take a closer look at which analogue of Hofitol to choose?
Medicine Hofitol
The drug belongs to the category of herbal medicines, so it is safe even for children, but from a certain age of the child. In addition, it has few side effects. The natural base of the drug is rich in microelements and vitamins, which are necessary to normalize metabolism, especially after taking antibiotics. A high concentration of biologically active substances helps to cope with dyspepsia and even relieve symptoms of toxicosis during pregnancy, restore kidney and liver function.
Composition and release form
The drug has several forms of release: tablets, injection and oral solution. The basis of each of them is an extract from the leaves of the field artichoke, contained in different concentrations. Hofitol - instructions for its use indicate that the drug also includes a number of excipients, different for each release form. The table shows in detail the composition of the drug:
| Lamisil release form | Active substance | Short description | Excipients |
| Pills | Dry leaf extract of Cynara scolymus (field artichoke) – 200 mg | Biconvex shape, round, brown. Available in aluminum blisters of 60 pieces or propylene tubes of 60 or 180 pieces. | magnesium stearate; pregelatinized corn starch; magnesium trisilicate; talc; components of the tablet shell. |
| Oral solution | Thick aqueous artichoke extract – 200 mg/ml | Available in the form of syrup (drops) or suspension in dark glass bottles. | ethanol 96%; tincture of orange peel in alcohol; purified water; additives E216 and E218; glycerol. |
| Injection solution for parenteral use | Purified field artichoke leaf extract – 20 mg/ml (100 mg/amp.) | Sold in ampoules of 5 pieces in a cardboard box. | distilled water – 5 ml. |
Pharmacodynamics and pharmacokinetics
The active component artichoke is rich in a complex of vitamins, ascorbic acid, inulin and other biologically active substances. The combination of cynarin and phenolic acids in the leaves has a choleretic effect. Carotene and B vitamins help the body normalize metabolic processes. Additionally, Hofitol has a diuretic and diuretic effect. The effect of the drug is due to the combined influence of its constituent substances, so identification of metabolites and kinetic observations are not possible.
Indications for use
Hofitol - instructions for use indicate that it can be used either independently or as part of complex therapy in combination with other drugs. In the first case, it is prescribed for the purpose of treatment and prevention:
- liver cirrhosis;
- chronic non-calculous cholecystitis;
- chronic hepatitis;
- gestosis (late and early toxicosis during pregnancy);
- dyspeptic disorders with nausea, heartburn, flatulence, feeling of heaviness in the abdomen;
- chronic nephritis;
- dyskinesia of the biliary tract of the hypokinetic type with lethargy and slowing of bile outflow.
Preparations based on field artichoke are often included in complex therapy with other drugs. In this case, treatment is carried out against diseases such as:
- anorexia;
- obesity;
- uraturia;
- chronic intoxication with alkaloids, hepatotoxic substances, nitro compounds;
- urolithiasis disease;
- atherosclerosis.
Belarusian generics
Belarusian generics are a good solution in finding an answer to the question of how to replace hofitol. The table will help you determine an inexpensive, effective medicine from Belarusian pharmaceutical companies.
| Name of the drug | Average price in rubles | Characteristic |
| Sandy immortelle flowers | 75–80 | The cheapest drug, identical to hofitol in its effect on the body. |
The product is available in the form of granular powder, which is diluted with boiled water and consumed orally before meals. Natural raw materials.
Phytohol120–300 The drug has a positive effect on the functioning of the liver and normalizes the mechanisms of the biliary tract.The vitamin complex in artichoke leaves has a beneficial effect on digestion and cholesterol levels. A synonym for hophytol from the category of cheaper drugs.
Milk Thistle Shrot40–55 Milk thistle fruits increase the secretory function of the gastrointestinal tract, relieve constipation, remove toxins, lower blood sugar, and also successfully remove toxic substances from the liver.Indications for use include diseases of the biliary tract, liver, gall bladder, hemorrhoids, atherosclerosis, dysbacteriosis.
Instructions for use of the solution for the liver
Despite the fact that the drug has virtually no side effects, it is not recommended to take Hofitol without studying the instructions for use.
Description of the drug
The Hofitol solution contains an active substance – artichoke extract (Cynara Scolymus L.). The plant contains a complex of phenols and bioflavonoids, which have a pronounced diuretic and choleretic effect. Additional components of the solution are:
- ethanol;
- flavoring;
- purified water;
- glycerol;
- E 218, E 214.
- Hofitol has three release forms:
- pills;
- oral solution;
- injection.
Biologically active substances help remove urea, heavy metal salts, alkaloids, nitrates and other toxic compounds from the body.
Indications and contraindications
Hofitol has indications for use and contraindications. The drug is prescribed to patients with the following diseases:
- impaired motility of the biliary tract;
- chronic acalculous cholecystitis;
- chronic hepatitis;
- fibrous changes;
- kidney diseases: nephritis, failure.
Complex therapy is prescribed if the patient has:
- intoxication;
- metabolic disorders (anorexia, obesity);
- atherosclerosis;
- urolithiasis disease.
The medicine is contraindicated in case of individual intolerance to the components. The choleretic effect of the drug can lead to complications if the patient has cholelithiasis, blockage of the bile ducts, acute inflammatory processes in the liver and kidneys.
How to take for adult patients?
Before taking the Hofitol solution, it must be shaken and then diluted with water
The solution is prescribed with caution to patients with alcoholism, since the drug contains ethyl alcohol.
Medicine dosage
The instructions for use provide dosages of the Hofitol solution for adults. A single dose is 2.5 or 5 ml of solution (corresponding to 0.5–1 teaspoon), diluted in 15 ml of water. The maximum daily dosage is 15 ml of solution.
Before or after meals?
The choleretic effect of the Hofitol solution determines how to take the medicine - before or after meals. Taking the medicine before meals activates the digestion process. How many minutes before meals to take Hofitol is not indicated in the instructions. Gastroenterologists recommend drinking the medicine 15 minutes before meals.
If you take the drug and do not eat, undesirable effects are possible - nausea, belching.
Application for children
Hophytol in solution can be given to children. Dosage is calculated by age:
- up to a year - 5-10 drops diluted in a teaspoon of water;
- from one to 6 years – 10–20 drops diluted in a tablespoon of water;
- from 6 to 12 years old, 2–3 ml are prescribed;
- Children over 12 years of age are prescribed an adult dosage.
The drug is indicated 3 times a day 20 minutes before meals.
Treatment of jaundice in newborns
For jaundice in newborns, Hofitol is prescribed as an adjuvant to accelerate metabolic processes in hepatocytes. The product helps remove toxins from the body. The drug is given only after being prescribed by a pediatrician strictly in accordance with the instructions for use of the solution.
During pregnancy
Hofitol is a herbal medicine that does not cause malformations in the fetus. Therefore, the drug can be taken by pregnant women. Gynecologists prescribe the medicine to normalize metabolic processes and support a woman’s liver and kidneys. The drug is also prescribed to improve blood circulation in the placenta.
Important! Clinical studies have confirmed that the drug increases the flow of oxygen to the fetus, thereby improving all its vital signs.
How long to store after opening?
The validity period of a closed bottle is 4 years at a temperature not exceeding 25 degrees. No more than two months in accordance with the temperature regime is the answer to the question of how long to store Hofitol after opening.
Indications and contraindications for use
Indications for use are kidney diseases; they are also prescribed for certain liver pathologies. Among them:
- chronic renal failure;
- chronic nephritis;
- insufficient urine output;
- hepatitis;
- cholecystitis;
- cirrhosis.
Among the contraindications to the use of Hofitol:
- hypersensitivity to artichoke and other components of the drug;
- acute liver and kidney diseases;
- cholelithiasis;
- severe liver dysfunction;
- severe renal failure;
- insufficient patency of the urinary tract;
- insufficient obstruction of the biliary tract.
Release form, composition and packaging
Hofitol is produced in:
- tablets (60-180 pcs),
- injections (100 mg 1 ampoule),
- suspensions (200 ml) in the form of a thick artichoke extract, which is preferable for children,
- syrups (120 ml) in bottles.
Hofitol in ampoules for injection Hofitol Hofitol
The composition of the tablets contains:
- Vole artichoke (dried aqueous extract),
- excipients: rosin, talc, sucrose, gelatin, disperse dye, calcium carbonate.
Solutions:
- aqueous extract of field artichoke,
- ethyl alcohol, orange flavor, purified water, methyl parahydroxybenzoate, dietary supplements E218 and E 216.
Injections:
- field artichoke (leaves) purified extract,
- distilled water (5ml).
The packaging form is cardboard. The tablets are placed in polypropylene tubes and blisters.
Mode of application
Hofitol in tablet form:
- for children from six to 12 years old: one tablet of the drug three times a day;
- for children over 12 years of age and adult patients: up to two tablets of the drug three times a day;
- Duration of use of Hofitol: no longer than three weeks.
Hofitol in the form of an oral solution:
- for children under 15 years of age: up to one and a half milliliters of the drug three times a day;
- for children over 15 years of age and adult patients: up to three milliliters of the drug three times a day;
- Duration of use of Hofitol: up to three weeks.
Chophytol in the form of a solution for injection:
- for children under 15 years of age: up to half an ampoule of the drug three times a day;
- for children over 15 years of age and adult patients: up to two ampoules of the drug three times a day;
- Duration of use of Hofitol: up to 15 days.
Features of application:
- The drug in the form of an injection solution can be used intravenously and intramuscularly;
- Repeated courses of using Hofitol in tablet form are possible only as directed by a specialist.
How to replace the drug
If there is a need to select a replacement for Hofitol, then only the attending physician selects and prescribes a suitable analogue. The following drugs have a similar therapeutic effect:
- Allohol;
- Ursosan;
- Cenarix;
- Ursofalk;
- Artichol;
- Holosas;
- Phosphogliv;
- Holenzyme;
- Liv 52;
- Gepabene;
- Karsil;
- Flamin;
- Heptral;
- Livodex.
Characteristics of some analogues of Hofitol - table
| Name of analogue | Category | Description |
| Allohol | Release form | Pills |
| Active substance |
| |
| Indications |
| |
| Contraindications |
| |
| From what age is it used? | From 7 years old | |
| Price | Tablets, No. 10 – 8.60 rub. | |
| Holosas | Release form | Syrup |
| Active substance | Rose hip extract | |
| Indications |
| |
| Contraindications |
| |
| From what age is it used? | From 3 years | |
| Price | Syrup, 140 g - 70 rub. | |
| Hepatophyte | Release form |
|
| Active substance | Assembled:
In tablets:
| |
| Indications |
| |
| Contraindications |
| |
| From what age is it used? |
| |
| Price | Herbal collection, No. 20, filter bags of 1.5 g - 179 rub. | |
| Gepabene | Release form | Capsules |
| Active substance |
| |
| Indications |
| |
| Contraindications |
| |
| From what age is it used? | From 6 years old | |
| Price | Capsules, No. 30 – 465 rub. | |
| Holenzym | Release form | Pills |
| Active substance |
| |
| Indications |
| |
| Contraindications |
| |
| From what age is it used? | From 7 years old | |
| Price | Tablets, No. 50 – 206 rub. |
Contraindications
Before starting treatment, it is important to read the instructions for use of the drug, because it has a number of contraindications. Their list includes:
- obstruction of the bile ducts due to stones;
- individual intolerance to components;
- acute form of cholecystitis;
- acute stages of kidney disease;
- age up to 6 years (for tablet form);
- stage of exacerbation of chronic diseases of the urinary tract and liver pathologies;
- breastfeeding period.
The use of Hofitol in pediatric practice
In pediatrics, solutions for oral/parenteral use are prescribed without age restrictions, tablets are prescribed to children over six years of age.
Indications for use in children are acute or chronic hepatitis, acalculous chronic cholecystitis, fatty hepatosis, motility disorders and decreased tone of the gallbladder and its ducts, increased concentration of acetone in the blood, intoxication (salts of heavy metals, nitrates, etc.), oliguria, chronic renal failure. , chronic nephritis, skin diseases (acne in adolescents, psoriasis, etc.), dyspeptic disorders, obesity, neonatal jaundice.
Children over twelve years of age are prescribed tablets at the same dose as adults. The daily dose of Hofitol tablets for children 6-12 years old is 600 mg (the dose should be divided into three doses).
The optimal dosage form for newborns is drops. According to the instructions for Hofitol, for newborns it is necessary to measure 5-10 drops of the medicine for each dose. The medicine is given on an empty stomach 3 times a day. Before giving the child Chofitol in drops, the required dose is first dissolved in 5 ml of water.
For adolescents over twelve years of age, 2.5-5 ml of solution is diluted in 1 tbsp. l. water. For children under twelve years of age, take 2-3 (depending on age and indications) milliliters of the drug for the same volume of water. The indicated dose should be taken 3 times a day. 20 minutes before meals.
Reviews of Hofitol for children indicate that the drug not only copes with its task very well, but is also very well tolerated by young patients
In addition, the drug is very convenient to use and easy to dose, which is very important when it comes to treating infants
For newborns, reviews confirm this; the drug is prescribed mainly in cases where the child has physiological jaundice for a long period.
An excessive increase in the concentration of bilirubin in the blood during pathological jaundice is dangerous because it can lead to the development of non-infectious damage to brain structures.
Timely use of Hofitol for newborns helps normalize liver function and biotransformation of insoluble toxic indirect bilirubin into non-toxic direct bilirubin. Mothers of young children note that the child’s blood bilirubin decreased on average by the ninth day of life, and by the end of the second or third week, the symptoms of jaundice completely disappeared.
Use of the product during pregnancy
Pregnancy is a special period in a woman’s life when her entire body and she are completely tuned in to bearing a fetus.
So, often during 9 months of bearing a child, the expectant mother may encounter many problems, including liver, stool, gall bladder and other troubles. After a complete examination, the attending physician prescribes medications to the pregnant woman to improve her condition. Only medications that are safe during pregnancy are allowed. Reviews of Hofitol among pregnant women are extremely good. Thus, it has a softening effect on oxidative processes in cells, has a mild diuretic effect and improves the functioning of the gallbladder. The drug is also able to improve blood flow to the placenta, which has a beneficial effect on the unborn child. According to reviews, Hofitol is absolutely safe during pregnancy.
Release form
"Hofitol" is produced in three different forms:
- Solution. This medicine is an opaque brown liquid in which you can see a yellow sediment (this is normal and is not a sign of spoilage of the drug). The solution is placed in dark glass bottles in an amount of 120 milliliters.
- Pills. They are distinguished by a convex round shape and a dense brown shell. This “Hofitol” is packaged in blisters of 12-30 pieces or in plastic tubes. One pack contains 60 or 180 tablets.
- Ampoules. They are sold in 5 or 12 pieces per pack and contain 5 ml of clear solution. Such a liquid usually has a yellow tint, which can be either barely visible (the solution appears colorless) or darker.
Hofitol for children
It has been proven that Hofitol in syrup and drops is completely safe for children, so it can be used from birth. In pediatrics, indications for use of the drug may include:
- physiological jaundice of newborns (reduces the level of bilirubin in the blood);
- dyspepsia;
- acetone in the blood;
- dyskinesia;
- viral hepatitis.
Children from birth and infants are allowed to give drops of Hofitol, which is diluted with water. Give the medicine on an empty stomach, 5-10 drops, after mixing them in water.
From 6 years old you can use tablets and syrup. 1 tablet or 5 ml of the drug 2 - 3 times a day before meals or an hour after meals.
Treatment of children with Hofitol lasts 2–3 weeks.
Course and regimen for children
"Hofitol" is produced in the form of drops and tablets. The tablets are intended for use by children over 6 years of age (who can swallow the tablet). But if a small patient refuses the pill, he can be given Hofitol drops instead - the therapeutic effect will be the same.
For children under 6 years of age, the drug is prescribed in drops. The medicine has an unpleasant taste, but a solution diluted with water is much easier to give to a baby than tablets.
In order for a lasting positive effect to occur from taking the drug, it must be taken in a course. Course duration is 2-3 weeks; if this is not enough, the pediatrician can extend the course of treatment to 30 days.
Up to a year
For children, the product is prepared in drops; the dosage of the drug “Hofitol” is indicated in the instructions for use for children: 5-10 drops of the drug are diluted with 5 ml of boiled water and given to the baby three times a day before meals (on an empty stomach).
1-6 years
For children from one to six years of age, this drug is prescribed in liquid form. According to the instructions for use, the Hofitol solution for oral administration is diluted as follows: add 10-20 drops of the drug to 15 ml of boiled water. You need to take the medicine three times a day, half an hour before meals.
6-12 years
For older children, the dosage of the drug is increased several times. The age group of young patients from 6 to 12 years old consumes the medicine in this form: 40-60 drops of medicine (0.5 teaspoon) are mixed with 15 ml of cooled boiled water.
This solution is taken 3 times a day 30 minutes before meals.
Over 12 years old
"Hofitol" is prescribed to adolescent children from 12 to 18 years of age in the form of a solution in the dosage: 1 teaspoon of the medicine is mixed with 15 ml of cold boiled water. This amount is taken 3 times a day, on an empty stomach, half an hour before meals.
Did you know? The artichoke has gone hand in hand with humanity for almost five long millennia. The ancestral home of this plant is North Africa. The population of Ancient Egypt knew about the healing properties of the artichoke. The Egyptians grew this plant as a separate crop and ate it.
Reviews of substitutes
Hofitol has won many positive reviews. Satisfied patients note a good therapeutic effect, mild action, and no side effects. Some users indicate a weak effect of the drug. Doctors speak positively about the medicine.
Patients' opinions
Patients write reviews about Hofitol analogues that are quite different, their opinions differ.
I have weak kidneys and often have inflammation. I take herbal preparations as maintenance, because they can be used for a long time without harm to health. I used to take Urolesan, but now I switched to Hofitol. I really liked the product, it does not cause any side effects. In addition, my digestion normalized and my appetite appeared. By the way, it is a very safe remedy - it was prescribed to my daughter during pregnancy. Her health and tests were all normal.
Tatyana Semenovna, 56 years old, Moscow
Prescribed to reduce swelling and to reduce uric acid in urine Hofitol. I took it for 2 weeks and then took the tests again. The swelling has gone down a little, but the uric acid has not decreased much. They prescribed me other medications that suited me better. I think that the medicine is rather weak as a diuretic.
Antonina Fomina, 35 years old, St. Petersburg
I have chronic pyelonephritis. I was prescribed to take Hofitol during remission. The doctor said that it helps restore organ tissue, stabilizes urea levels and generally has a beneficial effect on the kidneys.
Stepan Ostapenko, 40 years old, Ekaterinburg
Instructions for use
The attending physician must decide which dosage form of the drug is best after determining the exact diagnosis; it is also important to take into account the form of other prescribed drugs. For example, if a drug for intramuscular or intravenous administration has already been prescribed for liver cirrhosis, then it is best to choose Hofitol in the form of tablets or syrup for oral administration
Pills
Recommended for use from the age of 6 years. The daily dose of the drug is 1-3 tablets three times a day before meals. The more accurate dose is determined by the doctor, taking into account the patient’s age, as well as the nature and extent of the disease.
The duration of the course of taking Hofitol in tablet form is usually up to three weeks. A week after intensive use, the dosage of the drug can be gradually reduced. If you need to repeat the course, you must take a break for at least a month.
Solution
Hofitol solution is used for intramuscular administration. Usually prescribed 1 ampoule several times a day
It is important to ensure that the time interval between drug administration is the same. For acute forms of diseases, you can use 2 ampoules at a time
Hofitol solution can also be administered dropwise into a vein. This method of use is usually prescribed for serious illnesses when urgent therapy is required. The active substance is immediately absorbed into the blood and begins to act.
1-2 ampoules of the drug must be diluted in 200 ml of physiological solution. The drug is administered through a dropper very slowly. The procedure is repeated once a day at the same time.
https://youtube.com/watch?v=Kc7o9HG-rMg
Syrup
Hofitol syrup is taken 1 teaspoon before meals three times a day. Before use, shake the contents of the bottle well. If necessary, the treatment time with the drug can be increased by the attending physician to 1 month.
Similar sisterhoods
The pharmacological market offers analogues of domestic and foreign production. All of them have a positive effect on the functioning of the kidneys and urinary tract.
Some preparations have an active component similar to Hofitol - artichoke extract, others - milk thistle seed extract, corn stalks with stigmas, a collection of herbs.
Domestic substitutes
The list of domestic medicines with a similar effect includes:
- Silymar is a herbal preparation that has a positive effect on kidney function and, to a greater extent, liver function. Has a hepatoprotective effect, removes toxins. The active substance is milk thistle seed extract. Produced in Russia. The average price is 110 rubles.
- Silybin is a plant-based medicine that has detoxification, diuretic, and antioxidant properties. Helps improve microcirculation. Ingredients: milk thistle seed extract. Country of origin: Russia. Price – about 150 rubles.
- Corn columns with stigmas are a herbal medicine based on corn silks. It has a diuretic and choleretic effect, removes oxalates and phosphates from the body in the urine. It is used as part of complex and monotherapy for cystitis, urolithiasis, and liver diseases. Country of origin: Russia. The average cost is 70 rubles.
- Artichoke extract is a cheap analogue of Hofitol. The main composition includes artichoke extract. Under its influence, the excretion of urine, salts, toxins, and urea increases. Country of origin: Russia. The average price is 150 rubles.
Foreign analogues
Foreign drugs with similar effects include:
- Cynarix Forte is another analogue of Hofitol. It is used both for cholecystitis and for chronic nephritis and renal failure. It has choleretic, diuretic and hepatoprotective effects. The active ingredient is artichoke leaf extract. Country of origin: Austria. The average price is 200 rubles.
- Urolesan is a herbal preparation that has a positive effect on the kidneys. It has an antibacterial, anti-inflammatory, diuretic effect in the kidneys, urinary tract, and normalizes blood circulation in the liver. Also removes sand and urea. It contains peppermint (oil), extracts of hop cones, oregano, and wild carrots. Country of origin: Ukraine. The average price of syrup is 280 rubles.
- Herbion is a complex herbal preparation that includes artichoke. The purpose of the medicine is choleretic. But it is also used for liver diseases. The components of the drug have an anesthetic and antispasmodic effect on the muscles of the bladder and gall bladder. There is also an anti-inflammatory and moderate antiseptic effect. Ingredients: artichoke, peppermint, chamomile, parila herb, caraway seeds. Country of origin: Slovenia. The price of the medicine is 200 rubles.
- Artibel is a herbal preparation. It has a diuretic, antioxidant and choleretic effect. Actively removes urea and toxins, enhances the effect of antibiotics. The main component is a dry extract from the leafy part of the artichoke. Country of origin: Belgium. The average price for 60 tablets is 220 rubles.
Instructions for use of Hofitol
Before using Hofitol according to the instructions, it is important to take into account your weight and age. Recommended dosage form per day:
Recommended dosage form per day:
- tablets – 2-3 pcs.,
- syrup for infants up to 1 year, 10 drops 3 times by diluting in 5 ml of warm water,
- capsules for jaundice – 1-2 pcs. 3 times,
- solution for intravenous intramuscular injections – 2.5-3 ml 3 times.
Dosage per day for children, taking into account age:
- 1-3 years – 0.5 tablets 3 times,
- 3-6 years – 1 tablet 2 times,
- 6-12 years, 1 tablet 3 times.
Treatment course, 2-3 weeks. In order to prolong therapy, you should consult your doctor. Injections for children are prescribed for up to 15 days; then, as prescribed by a doctor, they can switch to oral administration of syrup or tablets.
If drops are used, the bottle must be shaken before use to prevent any sediment from entering the body. Drops by dilution in water, the recommended form of taking Hofitol for children from birth.
It is better to give the drug according to the instructions, on an empty stomach up to 3 times a day:
- infants up to 1 year – 7-8 drops with stirring in 5 ml of water,
- 1 year-5 years – 10-20 drops and 15 liters of water,
- 6-12 years, up to 60 drops and 15 ml of water,
- 12-18 years old – 1 tsp. Chophytol + 15 ml of water.
Attention! The dose of tablets per day should not exceed 1.2 g. Single dosage of syrup - 0.5-1 hour
spoon 3 times a day. Course of therapy, up to 3 weeks.
Use of hofitol during pregnancy and lactation
Thanks to its composition, Hofitol has a positive effect on the female body as a whole during pregnancy.
Promotes:
- normalization of bile flow,
- protecting the liver from harmful external influences,
- enhancing the removal of excess fluid,
- relieving puffiness,
- elimination of unpleasant symptoms: nausea, vomiting, diarrhea,
- improving metabolism,
- improvement of appetite,
- removal of nitrogenous wastes,
- protecting the body from the negative effects of free radicals,
- providing antioxidant effects,
- reducing blood cholesterol levels,
- improvement of placental-uterine circulation.
On a note! Women are allowed to take Hofitol if the benefits in relation to the possible risks to the fetus are justified.
So, if gestosis is detected at the beginning of pregnancy, the effect will be much higher than the acceptable harm to the child.
A drug:
- has an antioxidant, hepatoprotective effect,
- minimizes lipid degradation and oxidation,
- creating a protective barrier for the liver,
- increases the secretion of bile,
- has a diuretic effect,
- lowers cholesterol levels,
- normalizes blood circulation in the placental barrier.
It is possible to prescribe the drug to pregnant women with atherosclerosis and inflammation in the urinary tract. According to the instructions, Hofitol can improve overall well-being when drowsiness, dizziness, headache, and weakness are observed in the 1st trimester.
During pregnancy, fluid stagnates excessively in the tissues, which is fraught with complications and serious pathologies. Hofitol normalizes the functions of blood vessels and kidneys, prevents the formation of dropsy and edema.
Attention! Hofitol for children is not an antibiotic, so it is unlikely to be effective against bacterial infections. Additional use of other uroseptics is required
Doses should not be neglected. Average dosage per day is 50 mg. Course of treatment, 3 weeks. Women during pregnancy can take it in the form of syrup, 1 tsp. or 5 ml 3 times a day with a treatment course of 2 weeks.
The frequency and duration of the course is selected exclusively by the attending physician on an individual basis. Data on how safe the drug is for women during lactation have not been identified.
The recommended dose for injections should not exceed 5 ml, for tablets - 2 pcs. every 8 hours, in saline solution - 1-2 ampoules or 200 ml per day.
https://youtube.com/watch?v=JB4JBqKyFGc
pharmachologic effect
The pharmacological group of drugs to which Hofitol belongs are drugs that affect the digestive system (liver, biliary tract) and metabolism in the body. The clinical activity of the drug is ensured by the mechanisms of action of Artichoke extract. The main types of pharmacological action of the drug are as follows:
- choleretic;
- diuretic;
- restoration of liver cells;
- decrease in urea concentration in the blood;
- improvement of metabolism;
- removing toxins from the body.
Instructions for use
Chophytol is a choleretic and diuretic of plant origin that reduces the level of nitrogen-containing compounds in the blood. One of the dosage forms of the drug is a solution (sometimes called “drops” or “syrup”) for oral administration.
Indications
Hofitol solution is prescribed as part of combination therapy if the following pathologies are observed:
- dysfunction of the bile ducts of the hypotonic type;
- chronic acalculous cholecystitis;
- fatty hepatosis;
- liver diseases such as chronic hepatitis and cirrhosis;
- chronic kidney pathologies, namely renal failure and nephritis.
The drug is prescribed to alleviate functional digestive disorders, as well as to improve the excretory function of the kidneys.
Directions for use and doses
Drops are taken orally. The dosage of the drug is selected depending on the age of the patient.
| Age | Single dosage |
| From birth to one year. | The drug is prescribed from 5 to 10 drops, which is from 0.3 to 0.5 ml of solution. |
| From 1 year to 5 years. | Hofitol is prescribed from 10 to 20 drops or from 0.5 to 1 ml of solution. |
| From 6 to 12 years. | The medicine is prescribed in 2.5 ml (0.5 teaspoon). |
| Over 12 years of age (including adult patients). | The drug is prescribed in 0.5-1 teaspoon doses, which corresponds to 2.5-5 ml of solution. |
Hofitol should be taken 3 times a day before meals, the duration of therapy can vary from 2 to 3 weeks. The need for a repeat course is determined by the doctor in each specific case individually.
During therapy you should not drink alcohol.
Also, the drug should not be taken simultaneously with medications that cause disulfide reactions, such as:
- feeling of heat;
- skin redness;
- vomit;
- increased heart rate.
These medications include:
- disulfiram;
- cephalosporins;
- chloramphenicol;
- sulfonylurea derivatives;
- antimycotic drugs;
- 5-nitroimidazole derivatives;
- cytostatics.
Also, due to the alcohol content, Hofitol cannot be taken simultaneously with sedatives.
Contraindications
Hofitol solution should not be prescribed to patients suffering from the following pathologies:
- diseases of the genitourinary system in the acute stage;
- diseases of the liver and bile ducts in the acute phase;
- cholelithiasis;
- individual intolerance;
- obstruction of the bile ducts;
- severe hepatocellular failure.
Due to the ethyl alcohol content, drops should be prescribed with caution to patients who have:
- chronic alcoholism;
- epilepsy;
- traumatic brain injuries.
Overdose
If recommended doses are exceeded, increased side effects may occur.
There is no specific antidote, so the victim is prescribed symptomatic therapy.
Side effects
As a rule, therapy with the drug is well tolerated, only with hypersensitivity may the development of allergies occur.
In this case, you should immediately stop taking the medication and seek medical help.
Also, if you take the drug for a long time and in large dosages, stomach upset may occur.
Compound
The solution for oral administration contains a thick aqueous extract of fresh artichoke leaves as an active substance.
The additional components of the dosage form include:
- ethanol;
- glycerol;
- preservatives E216 and E218;
- orange flavor.
1 teaspoon of Hofitol solution contains 0.13 g of ethanol.
Pharmacology and pharmacokinetics
The therapeutic effect of the drug is observed due to the biologically active compounds contained in the artichoke.
Cynarin in combination with phenolic acids has a choleretic and hepatoprotective effect. Vitamin C, thiamine, riboflavin, carotene and inulin normalize the metabolism of substances.
In addition, the drug has a diuretic effect and accelerates the excretion of urea from the body.
The therapeutic effect is due to several active components, so it is impossible to study the pharmacokinetics of the drug.
All of its active compounds cannot be traced using biological studies and markers.
Also, because of this, it is not possible to identify drug metabolites.
Conditions of storage and sale
You can purchase the drug without a doctor's prescription. It should be stored at a temperature of maximum 25 degrees, out of the reach of children. The shelf life of the medicine is 4 years, after which the medicine must be disposed of.
Side effects of Hofitol
Hofitol is widely used in pediatric practice by pediatricians, gastroenterologists and infectious disease specialists. The drug has proven itself as an effective and safe remedy for children from the first days of life. However, despite all the positive aspects of a natural remedy, in rare cases, unwanted side effects may occur after taking it:
- softening of stool;
- diarrhea;
- skin rash.
If such symptoms appear, you should stop taking the medication and consult a pediatrician. The doctor will adjust the dose of the medicine or prescribe another drug with a similar effect. Many practicing pediatricians claim that the risk of side effects increases if the prescribed dose is not followed, so it is very important to strictly adhere to the dosage regimen.
Allohol
This is no less effective, but at the same time a cheap analogue of Hofitol. The main task of the drug is to restore liver tissue and bile ducts. In addition to its healing effects on the liver and gall bladder organs, Allochol also improves the functioning of the gastrointestinal tract. This is its main difference with its analogue. Due to its herbal composition and strong diuretic effect on the body, it can be given to children.
Allohol
The drug is produced by a domestic company in the form of tablets. One package may contain 10, 20 or 50 capsules. A tablet unit has the following number of components:
- 0.08 g of dry bile;
- 0.04 g chopped garlic;
- 0.005 g nettle leaf squeeze;
- 0.025 g activated carbon.
The drug is prescribed if the patient experiences:
Cholecystitis
- regular constipation;
- acute form of cholecystitis;
- chronic form of hepatitis or cholangitis;
- pathological liver damage (in the early stages);
- cholesterosis or dyskinesia of the gallbladder.
The drug is often prescribed to older children with pathologies of the gallbladder and bile ducts. The dosage for adults compared to children differs in the minimum amount of active substance.
The drug is also recommended for patients to restore liver and gallbladder cells after surgery.
It is forbidden to take the medicine if the patient has the following problems:
- sensitivity to one or more components of the drug;
- jaundice of obstructive type;
- peptic ulcer of any type;
- acute form of hepatitis;
- calculous cholecystitis;
- hepatic dystrophy in acute form.
Women during pregnancy and lactation are advised to consult a physician before using Allochol. At the same time, the drug has no specific contraindications for this category of people.
Heartburn
Side effects to the drug are rare. They are mainly associated with overdose and ignoring contraindications. Side effects from taking the drug include allergic skin rashes, heartburn, belching and stomach pain.
In pharmacies, the average price of the drug is 16–20 rubles.
What are the contraindications and side effects?
The tablet form of the drug is contraindicated in children under six years of age. The medicine should not be taken if there are pathological changes in the kidneys, liver, urinary and biliary tracts. If a patient suffers from individual intolerance to field artichoke or other ingredients of the drug, then he is strictly prohibited from taking Hofitol.
In general, the drug is well tolerated by the child’s body and is considered quite effective. In some cases, long-term use of the drug causes hypersensitivity reactions in patients - itching appears, the skin turns red, swelling, rash, and urticaria occur.
If you use Hofitol in large quantities for a long time, the drug can also provoke a number of side effects. The most common of these are gastrointestinal disorders.
Hofitol should be used strictly following the dosage prescribed by the doctor. If the drug is used in excessive doses, an overdose is possible. It manifests itself through an increase in the above side effects. If these symptoms occur, it is recommended to consult a doctor and carry out symptomatic treatment.
Analogs
If you need to replace “Hofitol” with a medicine containing the same active substances, you can use the drug “Artichoke extract”. It is produced by several manufacturers in the form of dragees, coated tablets or capsules, and the content of artichoke extract in such a product is 100, 200 or 300 mg. Depending on the dose, it is prescribed from 6 or 12 years of age.
If it is necessary to give a choleretic drug to younger children, they usually choose the drugs “Flamin” or “Holosas”. Thanks to the convenient form of granules for use in childhood, Flamin can be used even in the youngest patients. The suspension prepared from them is contraindicated only for newborns. The effect of the drug is due to biologically active compounds that are obtained from immortelle flowers. There are also Flamin tablets, but they are not prescribed to children under 12 years of age.
As for the drug "Holosas", it is a sweet syrup containing an extract from rose hips. It has a choleretic effect and the ability to protect liver cells from damage. This drug can be prescribed to children in the same cases when Hofitol is prescribed, but it is contraindicated in children under 3 years of age.
An equally popular analogue of “Hofitol” can be called “Ursofalk”. The action of this drug is provided by ursodeoxycholic acid, which has strong hepatoprotective properties. In the form of a suspension, this medication can be given even to newborn babies, and tablets and capsules are prescribed to children over three years of age.
For older patients, Allohol can also replace Hofitol. In the composition of these tablets you can see dry bile and activated carbon, and the herbal components of this medicine are obtained from garlic and nettle.
For instructions on using the drug "Hofitol", see the following video.
Hofitol solution has a choleretic and diuretic therapeutic effect. It is used for complex therapy of various pathologies of the liver and kidneys.
What is better – Hofitol or analogues?
Instead of Hofitol, the doctor may prescribe analogues with a choleretic effect. You cannot change the drug yourself, since drugs with similar effects may contain other active ingredients.
Allohol
To understand which is better – Hofitol or Allochol, you need to understand the composition of the drug. Allochol does not contain artichoke extract. The active ingredients of the medicine are nettle and garlic extracts, bile, and sorbent. Allochol is more effective in cases of atonic constipation. Hofitol does not have such an effect.
Ursosan
If you choose between the drugs Ursosan or Hofitol, which is better should be determined by your doctor. Ursosan contains ursodeoxycholic acid (UDCA). A drug is prescribed to dissolve gallstones. The medicine is indicated for fatty and alcoholic hepatosis, hepatitis. It is more effective, unlike Hofitol.
Ursofalk
If you figure out which is better - Ursofalk or Hofitol - for patients with cholesterol gallstones, then you need to choose Ursofalk. This product contains UDCA, which is an effective and powerful hepatoprotector. In the initial stages of the disease, it is better to give preference to artichoke.
Gallstones
Odeston
To answer the question, is Odeston or Hofitol better, you need to know that medications have different active substances. Odeston contains a synthetic component, the myotropic antispasmodic hymecromone. The medicine relieves pain and restores the flow of bile. However, the drug is contraindicated in pregnant women and patients with a tendency to bleeding.
Holenzym
If you have a choice between Hofitol or Cholenzym, you should choose Hofitol if you are allergic to components of animal origin. Cholenzym contains natural bile and components of the pancreas and small intestine of animals. The drug is an enzyme and a choleretic at the same time. What is better to take – Cholenzym or Hofitol – the doctor should explain in each specific case.
Karsil
Karsil also refers to herbal preparations. However, it is better to take it for liver diseases as a hepatoprotective agent. Hofitol is more effective as a choleretic agent. Which is better - Karsil or Hofitol, depends on the course of the disease and the desired effect: determined by the doctor.
Cynarix
Cynarix is an Austrian drug based on artichoke. The medicine is an absolute analogue, therefore, which is better, Cynarix or Hofitol, is determined only by the cost of the medicine. Hofitol is somewhat more expensive, but Cynarix has a larger dose of the active substance in one tablet.
Flamin
Flamin belongs to herbal medicines, the active component of which is immortelle extract. The product improves the flow of bile. Prescribed to children and pregnant women. I prescribe the medicine as part of the complex therapy of giardiasis, so which is better – Flamin or Hofitol – is determined by the doctor according to the indications.
Holosas
Holosas contains rosehip extract and is a choleretic and hepatoprotective agent. It is used for vitamin deficiencies and as a general tonic. The drug can be taken with other drugs, so it does not matter which is better - Holosas or Hofitol. They can be taken together under the supervision of a doctor.
Gepabene
Gepabene belongs to the combined hepatoprotectors. The drug is indicated for spasms, as well as for the restoration of hepatocytes. If we are talking about what is better for children - Hofitol or Gepabene, the choice is Hofitol, since Gepabene is not prescribed in pediatrics.
Essentiale
Essentiale contains phospholipids, which, according to some data, restore hepatocyte membranes. If we consider Hofitol or Essentiale as choleretic drugs, then it is better to choose an artichoke. The drugs can be prescribed by a doctor at the same time.
Galstena
When it comes to choosing between the drugs Galstena or Hofitol, and which is better, preference can be given to artichoke if the patient has chronic kidney disease or gout. Galstena has a combined composition. The drug is used for obstructed bile outflow, symptoms of dyspepsia, and also as a preventive measure for the formation of gallstones.
How to take hofitol correctly
The dosage of the medicine and the course of treatment are determined by the specifics of the patient’s disease, his age, and medical history. The drug is taken before meals. Before drinking the liquid solution, it must be shaken thoroughly.
It should be taken into account that the drug does not have a negative effect on the ability to concentrate attention and reaction speed, therefore there are no professional restrictions. However, if side effects appear after taking the medicine, you should stop driving vehicles and machinery.
If we are talking about the drug in the form of drops, then special care should be taken, since each drop of the solution contains ethyl alcohol.
Depending on body weight, adult patients are prescribed 1 or 2 tablets up to three times a day. In the form of a solution, adults also take the drug 3 times a day, 1/2 or one teaspoon.
Usually the course of treatment does not exceed three weeks, but under certain circumstances the doctor may extend it up to a month.
Injections are administered once a day. The dosage ranges from 5 to 10 ml. If necessary, the doctor can adjust it. Typically, injections are administered over one to two weeks. After this, the patient is recommended to switch to other forms of release and take the drug orally.
What is better Allohol or Hofitol?
Both drugs are indicated for the treatment of liver and gallbladder diseases.
Destination:
- gastritis,
- gastroduodenitis,
- pancreatitis,
- cholecystitis,
- Giardiasis
Chophytol is indicated for toxicosis in pregnant women, in particular infants with heartburn, constipation, as a diuretic. Allochol contains artichoke as an active ingredient.
The drug promotes:
- removal of breakdown products from the biliary tract,
- normalization of gastrointestinal tract functions,
- relief from constipation,
- providing a choleretic effect.
It contains Allochol, natural ingredients and is cheaper. What is better, Allohol or Chofitol? It's difficult to answer. The drugs successfully fight bile formation and normalize digestion processes. Based on Hofitol, artichoke extract, based on Allochol, also artichoke.
But, according to patients, Allochol is more effective because it eliminates constipation well and quickly, enhances intestinal motility, eliminates fermentation processes and signs of flatulence.
Chophytol and Allohol are excellent choleretics, help stimulate the production of bile acids and increase bile secretion.
Chophytol additionally has a protective effect. Both drugs are bile-containing, so only your doctor can help you choose the best drug.
Hofitol for children is not able to cope with such problems alone, although it has proven effective in treating:
- psoriasis,
- hepatitis A,
- dyskinesia,
- jaundice,
- constipation
Positive dynamics and improvement in the condition of the skin are noted. The price of Hofitol is quite reasonable. This is a natural herbal composition and does not lead to side effects. Can be given to infants and used by women during pregnancy.
Application in obstetric practice
Why is the drug Hofitol used in pregnant women? Complications or diseases in women during different periods of gestation cannot be treated with most traditional synthetic medications. It is imperative to take into account the possible harmful effects on the fetus and the number of side effects of the drug. Along with gestosis, pregnant women often experience pathologies of the kidneys and urinary tract.
Due to its systemic effect on the entire body, Hofitol is used during pregnancy to treat:
- early toxicosis;
- dermatoses;
- liver dysfunction;
- therapy and prevention of gestosis;
- for fetoplacental insufficiency (improves blood flow, reduces intrauterine suffering of the fetus);
- for cystitis, pyelonephritis (in complex therapy).
Causes of fetoplacental insufficiency
Violation of the transport function and permeability of the placental barrier occurs for many reasons. One of them is a shift in the balance between the processes of peroxidation of fatty cell components and the antioxidant defense system in the mother-placenta-fetus system.
With fetoplacental insufficiency, fetal hypoxia develops, antioxidant protection decreases, free radical aggression and lipid oxidation increases, and placental cell membranes are disrupted.
Treatment regimen for pregnant women: 2 tables. 3 times a day or by injection in a hospital. The number of tablets can be increased as prescribed by the doctor.
In pediatrics
The instructions for use separately do not show anything about the possibilities of using the drug Hofitol for children, except for the dosage.
It is known that numerous attacks of body cells by free radicals lead to the activation of oxidation reactions, the development of various pathological processes and organ damage in children and adults.
- While taking Hofitol, a decrease in oxidative stress was recorded in children with obesity or metabolic disorders of proteins, fats and carbohydrates. At the same time, the effect of protecting the cells lining the heart cavity, blood and lymph vessels (endothelium) was observed.
- Hofitol is used for atopic dermatitis in children. This is one of the complex and common allergic diseases based on immune mechanisms. It manifests itself as inflammation of all layers of the skin. A significant factor in the development of the disease is considered to be dysfunction of the digestive organs. Depending on the identified pathology of the digestive tract, children with atopic dermatitis are prescribed cytoprotectors, motility regulators, or Chofitol as a hepatoprotector.
In neonatology
In newborns, it is used in complex therapy for prolonged jaundice of various causes with increased bilirubin levels and the risk of developing cholestasis. When switching to artificial feeding in infants taking Hofitol, stool normalization is observed within 3-4 days.
What is the drug and how does it work?
The main active ingredient of Hofitol is the juice extract of field artichoke leaves.
The drug has a positive effect on the body:
- reduces cholesterol and urea levels in the blood;
- stimulates bile synthesis;
- has diuretic and hepatoprotective effects.
The product is available in the form of tablets and solution.
Composition of the drug
The main ingredient of Hofitol in any form is artichoke. Its dried extract in the amount of 200 mg is added to the tablets. Other components in the medicine are: magnesium trisilicate, magnesium stearate, corn starch, disperse dye, calcium carbonate, sucrose, carnauba wax, gelatin. The composition of the shell dye includes: iron oxides, methyl parahydroxybenzoate, sucrose, ethyl parahydroxybenzoate.
The solution for oral administration contains a plant extract. Other components in the bottle contain: 96% ethanol, glycerin, propyl hydroxybenzoate, orange peel tincture, methyl parahydroxybenzoate, water.
The basis of the solution for injections is the juice obtained from the plant and distilled water. The concentration of the active substance is 200 mg.
Composition and pharmacological properties
The main active component of Hofitol is artichoke leaf extract. This compound has been proven to:
- accelerates the production and evacuation of bile;
- increases the liver’s resistance to pathological influences and activates the detoxification functions of this organ by stimulating the work of its enzyme systems;
- normalizes metabolic processes;
- accelerates the removal of urea from the body;
- slows down the reabsorption of salts and water in the kidney tubules, increases the rate of urine formation, reduces the concentration of fluid in tissues and serous cavities.
In addition to artichoke extract, Hofitol contains several auxiliary components. So, for the manufacture of tablets they use:
- magnesium trisilicate;
- gelatin;
- carnauba wax;
- iron oxide (black, yellow, brown);
- talc;
- sugar;
- ethyl parahydroxybenzoate;
- corn starch;
- methyl parahydroxybenzoate;
- rosin;
- magnesium stearate;
- gummilk;
- polysorbate;
- calcium carbonate.
The auxiliary components of the Hofitol solution are glycerol, ethyl alcohol, purified water, propyl parahydroxybenzoate, orange flavor and methyl parahydroxybenzoate.
special instructions
If unpleasant signs appear (nausea, diarrhea, abdominal pain), you should stop taking the drug and consult a doctor.
You should be extremely careful when giving Hofitol to children with diseases of the biliary tract and liver, since inadequate reactions, obstruction or deterioration of the liver are possible.
Due to the sucrose content, Chofitol should not be taken by children under 6 years of age in tablets for malabsorption syndrome, fructose intolerance, or sucrose deficiency.
It is not recommended to take the drug together with alcohol due to the ethanol content in the solution for oral use.
According to the injection instructions, Hofitol tablets are not capable of slowing down reactions or reducing concentration. The drops contain ethanol, which is something that people who operate vehicles and other machinery need to know.
The drug requires careful use for patients suffering from:
- epileptic seizures;
- pronounced cramps of the transverse muscles;
- chronic alcoholism;
- traumatic brain injury.
When using Hofitol for children (instructions), it is important to consider the dosage and body weight. It is preferable to give infants drops (5-10) by diluting with water (5 ml).
Dose for older children:
- 1-5 years -15 drops;
- 6-12 years – 50-60. The medicine should be given before meals 3 times a day.
Inhalations are not recommended for children under 3 years of age. The herbal medicine (field artichoke) has proven its safety and helps accelerate the excretion of bile, but can cause spasms and choking due to the inability of infants to expectorate excess.
It is best for children under 6 years of age to use the drug in an oral solution. In older children, before inhaling Hofitol, it is advisable to first consult with the treating pediatrician.
All analogues of Hofitol
Analogues in composition and indications for use
| Name | Price in Russia | Price in Ukraine |
| Sandy immortelle flowers Sandy immortelle | 46 RUR | 10 UAH |
| Bonjigar is a combination of many active ingredients | — | 20 UAH |
| Corn silk | 70 rub | 4 UAH |
| Olimethine peppermint oil, purified turpentine oil, essential calamus oil, olive oil, purified sulfur | — | — |
| Tansy flowers Tansy | 41 RUR | 8 UAH |
| Raphacholine C Artichoke, dehydrocholic acid, Peppermint, Black radish, activated carbon | — | 69 UAH |
| Holagol Turmeric, magnesium salicylate, peppermint, frangulaemodin, Eucalyptus rodum | — | 26 UAH |
| Choleretic collection Sandy immortelle, Trefolia, Coriander, Peppermint | 30 rub | 6 UAH |
| Coriander fruit Coriander | 40 rub | — |
| Polyphytol-1 Calamus, Immortelle sandy, Common oak, St. John's wort, Corn, Potentilla erectus, Peppermint, Dandelion, Wormwood | — | 32 UAH |
| Salvat Boldo, Buckthorn, Peppermint, Dandelion, Agrimony, Chamomile, Horehound | — | — |
| Flamin-Health Immortelle sandy | — | 44 UAH |
| Cynarix Artichoke | 194 RUR | 28 UAH |
| Phosphogliv Forte | 226 rub. | — |
| Berberine berberine bisulfate | 83 RUR | — |
| Cholesan is a combination of many active ingredients | — | 77 UAH |
| Allohol | 3 rubles | 6 UAH |
| Artichol | — | 15 UAH |
| Hepatophyte is a combination of many active ingredients | — | 20 UAH |
| Flamin | 118 RUR | 31 UAH |
| Holosas Rosehip | 63 RUR | 16 UAH |
| Artichoke-Astrapharm artichoke extract | — | 39 UAH |
The above list of drug analogues, which indicate substitutes for Hofitol , is the most suitable, since they have the same composition of active ingredients and coincide in indications for use
Different composition, may have the same indication and method of use
| Name | Price in Russia | Price in Ukraine |
| Ukrliv ursodeoxycholic acid | — | 82 UAH |
| Urdoxa ursodeoxycholic acid | 122 rub. | 850 UAH |
| Ursodex ursodeoxycholic acid | — | — |
| Ursoliv ursodeoxycholic acid | 711 RUR | 85 UAH |
| Ursolysine ursodeoxycholic acid | — | 77 UAH |
| Ursomax ursodeoxycholic acid | — | 270 UAH |
| Ursosan ursodeoxycholic acid | 3 rubles | 48 UAH |
| Ursofalk ursodeoxycholic acid | 91 RUR | 2 UAH |
| Ursochol ursodeoxycholic acid | — | 60 UAH |
| Choludexane ursodeoxycholic acid | — | 110 UAH |
| PMS-Ursodiol ursodeoxycholic acid | — | 422 UAH |
| Ursolac ursodeoxycholic acid | — | — |
| Ursonost ursodeoxycholic acid | — | 146 UAH |
| Grinterol ursodeoxycholic acid | 516 RUR | 395 UAH |
| Ursacline ursodeoxycholic acid | — | — |
| Ursodez ursodeoxycholic acid | 26 rub. | 800 UAH |
Indications
Artichoke activates the formation and secretion of bile, lowers cholesterol levels in the body, and also has a diuretic effect. The medicine is recommended for use in the following diseases:
- chronic hepatitis;
- inflammatory processes that attack the gallbladder;
- liver pathology, cirrhosis;
- nitrate intoxication, other intoxications.
Hofitol is effective in case of poisoning of the body with alcoholic beverages, in case of atherosclerosis, and also if the patient has problems with diuresis (for example, with a decrease in the daily volume of urine).
Doctors can also prescribe the drug for heart disease, psoriasis, fungal nail infections, nausea, and people diagnosed with kidney failure (but only in the early stages). Hofitol is recommended for use by patients who have problems with excess weight (for example, obesity).
Prescribing or continuing to take the drug is prohibited unless bile duct obstruction is excluded.
Holenzym
Cholenzim belongs to the middle group in terms of cost of Hofitol analogues. This is a medicine that has a positive effect not only on the functioning of the gallbladder and bile ducts, but also on the gastrointestinal tract.
Treatment with this remedy promotes an increase in bile in the liver and its active outflow through the bile ducts. However, there is practically no difference in the dosage and period of treatment with this medication.
In pharmacies, the drug can be found in its only release form - in the form of tablets for swallowing.
Holenzym
One pack may contain 10, 25, 30 or 50 tablets, each of which contains 0.1 g of animal substance:
- ground bile;
- chopped pancreas;
- dried mucous membrane of the small intestine.
Animal components are taken from cattle.
Indications for the use of the drug are the following health problems:
- chronic hepatitis or cholecystitis;
- increased gas formation;
- infectious diarrhea;
- ulcerative colitis or gastritis;
- not advanced form of pancreatitis;
- any symptoms of indigestion.
Diarrhea
In addition, the drug can be used to eliminate frequent flatulence, infectious diarrhea, and symptoms of overeating.
The drug has a list of contraindications similar to Hofitol:
- exacerbated chronic or acute pancreatitis;
- individual intolerance to the components of the drug;
- obstructive jaundice.
The average price for a medicine does not exceed 300 rubles.
In conclusion, it is worth saying that any of the named Hofitol substitutes requires consultation with your doctor before taking. In addition, you should choose the medicine carefully so as not to buy an expired product. It should also be taken into account that not all drugs can be taken at the same time with other medications. These simple rules will protect you from wasting money and adverse reactions of the body.
Sources
- Chophytol instructions for use
- THE DRUG "HOFITOL" IN COMPLEX THERAPY OF CHRONIC GLOMERULONEPHRITIS
- STUDYING THE INFLUENCE OF THE DRUG "HOFITOL" ON LACTATION FUNCTION IN MULTIPARABLE WOMEN WITH GESTOSIS
- CHOFITOL IS A STANDARDIZED ARTICHOKE EXTRACT. BIOCHEMICAL COMPOSITION AND PHARMACOLOGICAL EFFECTS
- ASSESSMENT OF THE INFLUENCE OF THE ANTIOXIDANT OF PLANT ORIGIN "HOFITOL" ON THE PROCESSES OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION OF BLOOD SERUM IN MULTIPAPARUS WITH GESTOSIS IN COMBINATION WITH IDA
- USE OF CHOFYTOL FOR ANEMIA IN PREGNANT WOMEN
Ursosan
One of the most popular, inexpensive analogues of Hofitol is Ursosan. The drug belongs to the hepatoprotective group of drugs. Like Hofitol, it acts as a choleretic agent. It also has hypocholesterolemic (reduces cholesterol in the blood), cholelytic (eliminates cholesterol plugs) and immunomodulatory (increases the level of immunity) effects on the body.
The drug is produced by a Czech company in tablet form and capsules, the active substance of which is ursodeoxycholic acid. One pack may contain up to 0.25 g or 0.5 g of active substance.
Ursosan is prescribed for:
- uncomplicated form of gallstone pathology;
- chronic, viral or acute form of hepatitis;
- chronic cholecystitis;
- biliary dyskinesia;
- initial stage of cirrhosis of a parenchymal organ;
- gastroesophageal reflux disease;
- biliary reflux gastritis;
- chronic form of opisthorchiasis.
Ursosan
The drug is also recommended for use by people with alcohol addiction, which has led to liver damage, and in the form of prevention of the negative effects of hormonal drugs.
The drug is prohibited for patients who have:
- dysfunction of the bile ducts;
- aggravated form of any gallbladder disease;
- excess calcium in stones;
- advanced cirrhosis of the liver;
- liver failure;
- hypersensitivity to the composition of the drug.
The instructions for the medication do not recommend giving it to children under three years of age, since a small child may choke on a large capsule. Use of the drug by older children is possible only with careful adherence to the dosage of the drug.
Side effects include nausea, vomiting, diarrhea, severe stomach pain, skin rashes and itching in different parts of the body. In rare cases, pain in the spine is observed. If all these symptoms are present, the drug should be stopped.
The cost of a cheap analogue depends on the volume of packaging and the place of sale of the product. The retail price in pharmacies is 250 rubles.
Flamin
Another good and inexpensive analogue of Hofitol in tablets is Flamin. This is a herbal preparation, the main effect of which is aimed at stabilizing the functioning of the gallbladder and the general condition of the biliary tract.
The main ingredient of Flamin is sandy immortelle flowers. Unlike previous analogues, this product is produced in the form of ointment, powder, syrup, tablets, drops and whole raw materials in briquettes. One tablet contains 0.05 g of the main substance.
Flamin
The drug helps well in the following cases:
- acute cholecystitis;
- hepatocholecystitis;
- cholelithiasis;
- dyskinesia of the gallbladder and its passages.
Flamin is prohibited for use if the following problems exist:
- cholelithiasis;
- hypersensitivity to the components of the drug;
- acute form of diseases of the bile ducts and liver;
- exacerbation of stomach ulcers;
- renal failure;
- obstructive jaundice.
As in the previous case, a side effect of the body on Flamin also occurs rarely and is expressed in a sharp increase in blood pressure (in hypertensive patients) and urticaria. In addition, it should not be taken together with other choleretic drugs.
The price of Flamin in pharmacies is on average 250 rubles.
Drug interactions
Hofitol contains ethyl alcohol, so it is not advisable to use it in combination with the following drugs:
- cephalosparins (Cefamandole),
- derivatives of 5 Nitroimidazole (Tinidazole, Metronidazole, Ornidazole),
- cytostatics (Procarbazine, Sulfonylurea, Glipizide, Tolbutamide, Disulfiram, Chloramphenicol).
Disulfiram-like reactions, nausea, redness of the skin, sensations of heat, and attacks of tachycardia are possible. In particular, there may be adverse reactions when taking Hofitol to children in combination with antifungal agents (Ketoconazole, Griseofulvin).
It is not recommended for children to take Hofitol together with drugs that can suppress the functions of the central nervous system. Do not neglect dosages when taking solutions containing ethanol.
If other drops also containing alcohol are used, the effect may be reduced and the functions of the central nervous system may be suppressed.
Additional therapeutic effects
The official instructions for use of Hofitol contain very little information about the benefits of the drug. Many clinical studies of the drug were conducted on different groups of patients. Based on the results, a summary list of proven therapeutic effects of Hofitol can be given:
- hepatoprotective effect (activation and support of liver functions);
- choleretic;
- reduces morning bitterness in the mouth;
- diuretic, increases filtration function of the kidneys;
- antioxidant;
- reduces toxicometabolic effects on the brain;
- membrane stabilizing effect;
- increases resistance to inflammatory reactions, stimulates the immune system;
- participates in metabolic processes (carbohydrate, fat metabolism, lipid metabolism, ketone bodies);
- reduces cholesterol and bilirubin levels;
- reduces the excretion of urea, nitrogen and protein in pyelonephritis, chronic renal failure;
- stimulates apoptosis of cancer cells;
- removes cadmium and lead from the body;
- reduces symptoms of irritable bowel syndrome;
- normalizes stool, eliminates pain in the epigastric region, belching, flatulence.
Many scientific works have been written about the drug Hofitol and research articles have been published.
