The drug Qlaira, reviews from doctors, is taken during menopause

Advantages and disadvantages

Caution! Treatment with Qlaira for endometriosis is considered effective and safe - estradiol is a natural component, so the risk of negative effects on the body is minimized.
Unlike other oral contraceptives, tablets rarely cause thromboembolic complications. The drug has a flexible dosage regimen, which is also a clear advantage.

Advantages of taking Qlaira for endometriosis:

• good tolerance;
• getting rid of a large amount of menstrual flow and improving the patient’s quality of life;
• estradiol is a substance identical to natural, which minimizes the risk of side effects;
• the combination of active substances allows you to further increase the amount of “good” cholesterol and reduce the amount of “harmful” cholesterol.

Women who take Qlaira to eliminate the symptoms of endometriosis note an improvement in the condition of their facial skin and hair. Clear control of the menstrual cycle is also considered a plus. After completing the course of therapy, the patient can safely plan a pregnancy if the doctor considers the chances of conception high.

Like other hormonal drugs, Qlaira also has disadvantages:

• manifestation of frequent side effects - pain in the mammary glands, weight gain, bloating;
• increased risk of developing cervical cancer when infected with the human papillomavirus;
• quite high cost.

When prescribing a drug, the doctor, together with the woman, must study the advantages and disadvantages of Qlaira and decide on treatment with this drug, or on replacing it with another from the same pharmacological group.

Effective Rule

"Klaira" - reviews of women after 40 years: side effects

No matter how good the drug “Klayra” is, it has undesirable manifestations:

• gagging and feeling of nausea;
• pain in the peritoneal area;
• migraines and severe headaches;
• breast enlargement and discomfort in this area;
• weight gain;
• accumulation of fluid in tissues;
• vaginal candidiasis;
• menstrual irregularities;
• depression;
• blood pressure surges;
• lack of attraction to the opposite sex;
• skin reactions: spots, rashes;

• liver dysfunction;
• gallstones.

Research

The safety and effectiveness of estradiol valerate/dienogest tablets in the treatment of various symptoms of uterine dysfunctional bleeding were determined in two clinical studies.

The same packaging design and assay plan were used in both studies. Ultimately, 269 patients were selected to use Qlaira. Reviews from doctors (pros/cons are described in detail) participating in the study indicate that in addition, 152 patients were involved in the study, on whom the placebo effect was tested. These studies determined that the drug was significantly more effective than placebo in treating these symptoms, and it is worth noting that the response endpoint for Qlaira was more than 40% in each of the studies.

In addition, each of the studies clearly demonstrated a statistically and clinically significant reduction in menstrual blood loss, and in the future this was accompanied by a statistically significant increase in iron metabolism, which is currently often noted by doctors about the drug “Klaira” (we are considering the pros and cons of this drug) .

The estrogen in this drug is estradiol variate, which is a precursor of natural human 17β-estradiol. The estrogen component used in this product is significantly different from the estrogens typically used in combined oral contraceptives, which are standard synthetic estrogens such as mestranol or ethinyl estradiol, each of which contains an ethynyl group located at position 17α. This group provides significantly greater metabolic stability, but at the same time has a more pronounced effect on the liver, which is also quite important.

When describing the drug "Klayra", reviews from doctors often mention that its use has a much less pronounced effect on the liver compared to other three-phase COCs, which include levonorgestrel and ethinyl estradiol. During the research, it was determined that the effect on the concentration of globulin intended to bind sex hormones is less pronounced. When combined with dienogest, estradiol valerate shows a significant increase in HDL cholesterol, while the total concentration of LDL cholesterol decreases.

Dienogest is a progestogen that works when administered orally. It is distinguished by additional antiandrogenic partial effects, while its antiestrogenic, androgenic and estrogenic properties are negligible. Due to the unique chemical structure, a whole spectrum of pharmacological action is achieved, which includes the most significant advantages of 19-nor-progestogens, as well as various progesterone derivatives, which is often noted in the reviews available about the “Klayra” product (the pros/cons will be discussed below).

Preclinical data that were obtained through routine toxicity studies after multiple doses, as well as the carcinogenic potential and genotoxicity of this drug, did not show that there is any significant specific risk to humans. However, when describing the drug “Klaira”, reviews from gynecologists often say that one should not forget about the possibility of stimulating a number of tumors and hormone-dependent tissues with sex hormones. If used correctly, the so-called Pearl index (an indicator that determines the incidence of pregnancy in one hundred women during a year of using a particular drug) has a value of less than 1, but if pills are missed or used incorrectly, it may increase.

Next, the pharmacokinetics of the drug “Qlaira” will be considered. Reviews from gynecologists almost completely confirm the information provided by the manufacturer itself, which is why this drug is prescribed to many patients.

Estradiol valerate

• Absorption. Due to the administration of the drug estradiol, variate is absorbed quite quickly and completely. The breakdown into valeric acid and estradiol itself occurs during the absorption of this element in the gastrointestinal mucosa or during the first passage through the liver, as a result of which estradiol and its metabolites appear. If the drug is taken simultaneously with food, it does not have any clinically significant effect on the degree or rate of absorption of this element.

• Metabolism. Valeric acid has extremely rapid metabolism. After approximately 3% of the dose is ingested, it becomes completely bioavailable in the form of pure estradiol, which undergoes an intense effect of initial passage through the liver, as a result of which a significant part of the administered dose begins to be metabolized in the gastrointestinal mucosa. Combined with first-pass metabolism directly in the liver, approximately 95% of the total oral dose is ultimately metabolized before entering the systemic circulation. The main metabolites here are estrone sulfate, estrone and estrone glucuronide.

• Distribution. In blood serum, about 38% of estradiol is directly bound to SHBG, while 60% is bound to albumin, and only 2-3% constantly circulates in an unbound state. It is worth noting the fact that estradiol may not significantly increase the total concentration of SHBG in the blood serum, and this effect directly depends on the dose taken. On the 21st day of taking this drug, the total concentration of SHBG reached approximately 146% of the initial level, while by the 28th day, which is the end of the phase of using inactive tablets, it had already been reduced to 141%.

• Elimination. Due to the fairly large circulating pool of glucuronides and sulfates, as well as due to hepatic-intestinal recirculation, T1/2 of estradiol after oral use in the terminal phase is a complex characteristic directly dependent on all these processes.

• Equilibrium concentration. The pharmacokinetics of estradiol is directly dependent on the concentration of SHBG. In women, the concentration of estradiol in the blood plasma is a complex of endogenous estradiol, as well as the estradiol that comes in while taking this drug. During the phase of taking tablets containing 3 mg of dienogest and 2 mg of estradiol valerate, the average concentration of estradiol in the blood serum at an equal state is 51.6 pg/ml.

Side effects and contraindications

Like any medication that contains hormones, Qlaira requires an individual approach to each patient before starting treatment. This allows you to avoid negative consequences. Reviews from doctors about Klaira during menopause warn that the contraceptive is contraindicated in the following cases:

• individual intolerance to hormone-modulating components;
• negative reaction to lactose, galactosemia;
• tendency to form blood clots;
• diabetes;
• pancreatitis;
• kidney and liver diseases;
• bloody vaginal discharge of unknown origin;
• neoplasms;
• period of pregnancy and lactation;
• anemia;
• gallbladder damage;
• arrhythmia;
• angina pectoris, stroke;
• migraines complicated by impaired functioning of the organs of hearing, vision, and temporary loss of speech.

An overdose may cause gastrointestinal upset or vaginal bleeding. If it is necessary to combine the use of Qlaira with taking other drugs, you should consult a specialist. During the period of use, the following side effects may occur:

• nausea and vomiting;
• pain in the peritoneum;
• severe headaches;
• swelling, weight gain;
• candidiasis;
• disruption of the menstrual cycle;
• decreased libido, depression;
• skin rash;
• formation of gallstones.

Possible complications

Treatment with Qlaira tablets during menopause is most often tolerated satisfactorily.

In isolated cases, the drug causes the development of side effects:

• increased or decreased blood pressure;
• blood clot formation;
• dyspeptic disorders;
• liver hyperplasia, increased concentration of liver enzymes;
• lymphadenopathy;
• hot flushes;
• increased or decreased libido;
• emotional instability;
• headache;
• fast fatiguability;
• spotting during sexual intercourse;
• myalgia, muscle spasms;
• increased risk of breast cancer, uterine fibroids, cysts;
• increased irritability, aggressiveness;
• decreased concentration, seizures;
• allergic reactions;
• swelling, soreness, discharge from the mammary glands;
• amenorrhea, dysmenorrhea;
• mastopathy;
• weight gain;
• urogenital infections;
• dryness, burning, itching of the vagina.

Women at risk of developing complications include women who smoke, suffer from obesity, hypertension, frequent headaches, arrhythmia, and have recently undergone surgery. When taken during menopause, Qlaira can cause fluid retention in the body and swelling.

Changes in hormonal levels often manifest as weakened immunity; patients often suffer from vaginitis, herpes simplex, fungal or bacterial infections of the genitourinary organs.

When taking COCs simultaneously with other medications during menopause, metrorrhagia develops and the effectiveness of the contraceptive effect decreases. Breakthrough bleeding may occur when Qlaira is combined with inducers of microsomal liver enzymes. Anticonvulsants, some antibiotics and medications containing St. John's wort extract can reduce the clearance of the drug.

Composition of Qlaira

As noted above, the composition of the Qlaira hormones is represented by two substances: dienogest and estradiol valerate, as can be seen by reading the instructions for use. The composition contains auxiliary components:

• lactose monohydrate – helps increase the shelf life of the drug and adds sweetness to it,
• corn starch - acts as a binder,
• povidone – promotes the binding of toxins,
• Magnesium stearate – helps give tablets their shape.

The German company took care of the convenient use of “Klaira” and divided all the tablets into 5 colors. Each package contains dark yellow and light yellow, red, white and pink tablets. All tablets, except white ones, contain the active ingredient. In order not to get confused with the correct application, the manufacturer has provided detailed instructions.

Compound

Qlaira is a contraceptive for sequential use from the class of gestagens and estrogens. The tablets contain two active components - estradiol valerate and dienogest.

Each pill is consumed according to the scheme, on different days and contains different amounts of active ingredients:

• yellow – estradiol 3 mg;
• pink – estradiol 2 mg, dienogest 2 mg;
• light yellow – estradiol 2 mg, dienogest 3 mg;
• red – estradiol 1 mg;
• white (placebo) - include only auxiliary components.

This composition of the tablets increases the effectiveness of treatment, since it adapts to the natural changes in the endometrial layer that occur during the monthly cycle. Find out whether boron uterus and suppositories help treat endometriosis.

For whom the drug is contraindicated

Klaira, like all hormonal drugs, has an impressive list of contraindications

But doctors prescribe the drug with particular caution to women with blood diseases. After all, it promotes the formation of blood clots in blood vessels

Let's consider for which diseases and conditions the drug should not be taken:

1. Breastfeeding a baby. The drug should be discontinued before the baby is weaned.
2. Thrombosis and thromboembolism.
3. Have had previous strokes, mini-stroke or heart attacks.
4. Unstable blood pressure.
5. Heart valve disease or irregular heartbeats – arrhythmias.
6. High cholesterol levels.
7. Diabetes.
8. Serious diseases of the liver and biliary tract.
9. Malignant neoplasms of any location.
10. Migraine.
11. Obesity.

A contraindication to taking the contraceptive Qlaira is heavy smoking.

On what day do menstruation begin after stopping Qlaira?

For 2-3 months after stopping use of the drug, a woman may notice a change in the menstrual cycle - shortening or lengthening it. A cycle duration of up to 36 days is considered normal and does not require any special treatment. In some cases, women may experience a delay in menstruation after stopping birth control pills, sometimes for 2-3 months.

When discontinuing the pills, patients often notice increased hair loss, up to the formation of bald patches. This is caused by a sharp change in hormonal levels and the body needs time to restore the functioning of all organs and systems. In most cases, after a couple of months the condition of the hair follicles returns to normal, but if hair loss continues 2-3 months after stopping the drug, consultation with specialists is required.

Here is the action plan in this case:

• missed the dark yellow pill - no need to use a condom;
• missed the pink pill, use a condom for 9 days after missing the drug; pale yellow tablet from 8 to 17 in a row - use a condom for 9 days after missing the drug; missed pale yellow tablet from 18 to 24 in a row - use a condom for 9 days after missing the drug;
• Missed the red pill - no need to use a condom.

How to start taking pills from the first package?

• if you did not take hormonal contraceptives last month, then you should start using Qlaira at the first menstruation;
• if you are switching to Qlaira from another means, then you should start taking Qlaira the next day after you take the last pill from the previous contraceptive.

While taking the drug, the ovaries are blocked.

It takes time for the ovaries to resume normal functioning, usually about a month or two after stopping the pills.

But often a cycle failure can last up to six months. The first menstruation after stopping the drug may be heavy.

Klaira and thrush

Due to changes in hormonal levels, the patient’s immune system suffers and the fight against external negative factors decreases. An increase in estrogen in the blood leads to the accumulation of glycogen, which, in turn, contributes to the proliferation of fungal infections. Therefore, thrush may develop.

For uterine fibroids, Klaira suppresses the growth of foci of the disease and regulates the menstrual cycle.

The drug is prescribed under the following conditions:

• fibroid nodes no more than 2 centimeters;
• the size of the uterus together with the neoplasm is similar in size to 11 weeks of pregnancy;
• fibroids do not grow, symptoms are not expressed;
• there are no interruptions in the functioning of other female organs;

But it is impossible to achieve complete disappearance of fibroid nodes with hormones.

How to take Qlaira

You need to take Qlaira, like any other oral contraceptive, one tablet every day, regardless of whether intimacy is planned or not.

It is important to take the pill every day at approximately the same time, following the sequence indicated on the blister. A new package must be started regardless of whether menstruation has ended, is ongoing or has not yet begun.

Sometimes, when taking the last blister tablets, a woman may experience brown mucous discharge. Don't panic. They will go away on their own when the lady starts taking pills from the new blister

A new package must be started regardless of whether menstruation has ended, is ongoing, or has not yet begun. Sometimes, when taking the last blister tablets, a woman may experience brown mucous discharge. Don't panic. They will go away on their own when the lady starts taking pills from the new blister.

When to start taking the drug

It is important to start taking Qlaira correctly. Let's consider all possible options:

Let's consider all possible options:

1. The lady did not take any hormonal contraceptive pills during her previous menstrual cycle. People start drinking Klaira on the first day of menstruation.
2. If the patient took other combined oral contraceptives in the previous cycle, then the next day after the package runs out of active tablets, she can start taking Qlaira. She does not need to wait for her period, especially for its end.
3. In the last cycle, the woman used some kind of combined hormonal contraceptives: a skin patch, a vaginal ring, etc. She can start taking Qlaira the same day her birth control is removed.
4. When taking mini-pills in the previous month, which are gestagenic oral contraceptives containing only gestagens - analogues of the sex hormone progesterone, they switch to Qlaira as follows: the pills can be started on any day, but for 10 days they should be used during sexual contacts condom.
5. A woman who was protected from unwanted pregnancy with an intrauterine device or progesterone implants should start taking the pills on the day of removal of the device.
6. When long-term injections with progestogen drugs were used to protect against unwanted pregnancy, they switch to Qlaira on the day on which the next injection was scheduled.

Before you start taking Qlaira, you must consult a gynecologist.

Birth control after childbirth or abortion

It is important for ladies to know how many days after the procedure of termination of pregnancy or childbirth they can take Qlaira:

1. After an abortion performed before the 12th week of pregnancy, they start drinking Klaira on the day of the medical procedure. When an abortion was performed in the period from 13 to 24 weeks of pregnancy, they begin to drink Klaira 21-28 days after the procedure.
2. After giving birth, the optimal time to start taking Qlaira is 21-28 days. If a woman starts taking the drug later, then during the first 9 days, during intimate intimacy, additional protection in the form of a condom will be needed.

If after an abortion or childbirth there was sexual contact without protection, then before you start drinking Qlaira, you must make sure that pregnancy has not occurred. For this purpose, you should take a pharmacy pregnancy test, and also visit a gynecologist.

Reviews from women

Most of the women who took Qlaira leave positive reviews of the drug. It is well tolerated by the body and reliably protects against unwanted pregnancy. The main advantage is the slight bleeding while taking the contraceptive, which allows a woman to almost not feel the onset of menstruation. In addition, in the treatment of endometrium, judging by the reviews of women over 40 years old, “Qlaira” (moderate cost) gives excellent results.

Doctors claim that the product reliably protects women from unwanted pregnancy; few of the patients to whom it is recommended complain that they feel unwell or have difficulty taking it. It is well tolerated, reliably protects and does not require the use of additional protection if a dose is not missed.

You can buy the drug at any pharmacy; it has a long shelf life - 4 years. The cost of packaging at different pharmacies may vary, but it is still quite affordable. The price of “Klayra”, reviews of women over 40 years old confirm this, ranges from 650 to 1000 rubles.

Take care of your women's health, use reliable contraception to prevent the birth of an unwanted baby or abortion.

Hello dear girls) Please tell me, did Qlaira somehow affect someone’s hair? Has it become better, and most importantly for me, if it was falling out before, has it stopped falling out with this drug? This is VERY important for me!! this is the only reason why my gynecologist told me to drink Klaira. My hair is terrible, my hair is falling out catastrophically and, as tests showed, this is a hormonal imbalance .. I’m just in despair, a little more and there will be nothing to save ((( Please Share your opinion and advise me what to do!

I’m 38, the doctor prescribed it for me, everything is fine, at first I had a stomach ache for three days and that’s all. Then I noticed that insomnia had started, but I just started taking the pill in the evening, not before bed, but immediately when I got home from work. And by the time I go to bed, sleep comes normally.

Girls! who is about 45 years old and was prescribed Klaira to solve gynecological, hormonal problems and smoothly transition into an “interesting age”? Tell me, does it help? I already got acne from Rigevidon and bleeding from Charozette! (this was some time ago). Now I'm afraid to start other hormones.

I'm 49. I've been drinking Jess for 3 years without a break. From the 1st cycle all problems disappeared: spotting, PMS, endometriosis. I lost 2 kg. Just great. Nobody appointed. My daughter drank it and I decided to try it. Then the gynecologist said that I was drinking correctly. I prolong youth). Although at first I was afraid. Everything is individual.

There is a lot of useful information on the Sikirin forum about Klaira and other contraceptives.

Hi all! The doctor prescribed Klaira for me to regulate my hormonal cycle. I'm having a glitch. Menstruation may not come for two months. The doctor said the tablets are great: I don’t gain weight, the condition of my hair, skin, and nails improves. Well, in a word, it’s lovely, not pills! I’ve been taking it for the second month: on the 16th tablet, the smudge starts, my stomach feels tight. Weight +5 kg, hair is falling out, skin is dry, swelling. Besides, it's a terrible creepy thing! I roar even when watching movies. I lash out at my loved ones over trifles. Irritable, suspicious, complete apathy in mood. I’ll finish this pack, go to the doctor, let him change my medication.

The doctor prescribed Klaira for me because of myoma. I took all the tests in advance. I drink as prescribed by the doctor under the cover of cardiomagnyl 1 tablet. I don’t know how my fibroids are doing (I didn’t see a doctor until the end of January), but my overall health has improved, and the headaches have gone away. Libido is not lost. I'm waiting for my first period.

I haven’t gained weight, although I’ve only been drinking for 1 month. And my breasts didn't get bigger.

Acne and headache - this can usually be an addiction to the body. If it lasts 2-3 months. If more, then Klaira is definitely not suitable. And, by the way, acne is a rare side effect of Klaira. Anna Separately, you would like to write that Klaira does not cause weight gain.. Yes, the appetite may become a LITTLE bigger.. And you can add 1-2 kg.. but just don’t eat, girls, as you want these days) )) And the weight may become a little more due to breast enlargement..) A pleasant side effect..

Apparently not for everyone. I have been taking this drug for 1.5 months. Plbs 5 kilo. I'm shocked.

I started drinking 2 packs of Qlaira. My periods are not heavy, they are slightly painful, not like before I was cramped with pain.

I took Qlaira for 6 months. Every month I gained 1 kilo in weight. I quit, I haven’t taken it for half a year, the weight doesn’t go away, diets don’t help.

Please tell me what will happen if you stop taking Qlaira at 16-17 tablets?

Please tell me what will happen if you stop taking Qlaira at 16-17 tablets?

Now I can’t remain silent. I've been taking Qlaira for almost six months. Reason for prescription: endometriosis, heavy bleeding, as a result of low hemoglobin, then they discovered a polyp and after its removal they prescribed K. I read a lot of reviews, didn’t find any negative ones, but there are so many advantages: libido has increased, breasts have grown, and the skin is clearer, etc. . Okay, I think this is all not superfluous. Started the appointment. My result: after 3 months I feel better, my clothes became small, my tummy appeared, I weighed myself - 5 extra kilos (although the diet has not changed and the physical activity is the same); I took tests to the clinical examination and found an increase in sugar (I don’t know what to blame, but before taking K. there was nothing like that). Plus - only scanty periods. And now the most important thing is that I’ve been undergoing treatment with a coloproctologist for a week! Yes Yes! Hemorrhoids came out! It's not even called hemorrhoids, but thrombosis of hemorrhoids! Maybe someone can imagine what kind of pain this is! External nodes. The doctor clearly stated the reason - taking K. Hormonal drugs influence the occurrence of blood clots. Now I walk like a lame duck due to pain in my butt, sorry. The first days I sat and slept only on my side. The treatment was said to last a month. Damn pain! So my experience is sad: instead of growing libido and breasts, I only grew these painful nodes! It would be funny if it didn't hurt so much! Skin, hair - I don’t see any improvement anywhere either.

Yes, I also missed all of the above: all the time I was taking K., thrush “has been bothering me.” Endless itching and burning. (

I’m 43 years old, I haven’t had my period for six months, I was examined, the doctor said that I prescribed Klaira for menopause. I took the 13th tablet, do I need to take additional protection?

They prescribed Klaira after a miscarriage to treat the endometrium. As a result, after 3 months of taking it, 2 cm fibroids and polyps grew. They sent me for endometrial aspirate. For analysis in a week. In my case, it turned out that they were not curing, but crippling...

Drug interactions

The instructions for each drug indicate what interactions the drug has with other drugs and alcohol. “Qlaira” is no exception: when taking it, you should follow the recommendations in the instructions.

"Qlaira" and antibiotics

According to the instructions for use, if a woman takes antibiotics while taking Qlaira, the following steps must be taken:

1. After antibiotics, additional contraception should be used for 28 days.
2. After 28 days, when switching to a new pack of the drug, you do not need to use additional protection.

Comment! Some women, after a course of antibiotics, notice side effects such as spotting between periods; if this happens, you should consult a gynecologist.

If you follow these measures after taking antibiotics, an unwanted pregnancy will not occur.

Compatibility of "Klayra" and alcohol

According to the official instructions for the drug, o and alcohol can be consumed together, however, this should be done in moderation. With a high dosage of alcohol and simultaneous use of COCs, the load on the liver increases, which entails negative consequences.

Doctors note: the time interval between taking the drug and alcohol should be from 5 to 9 hours.

"Qlaira" and smoking

Smoking while taking Qlaira increases the risk of thrombophilia, as indicated in the instructions. This complication can occur in women who smoke after 35 years of age, so gynecologists do not recommend the drug at this age if they are constantly smoking.

When starting to take the drug at a younger age, women who smoke are advised to take a test for hereditary thrombophilia, as well as take a coagulogram three times a year.

Dosage

The medicine is prescribed for oral administration, one tablet daily for 21 days from the start of the menstrual cycle. It is advisable to take the tablets at the same time, chewing and drinking a small amount of water. After taking the last capsule, you must take a seven-day break. It is worth adhering to this algorithm until the woman begins to plan a pregnancy.

Before starting to use the drugs “Novinet” and “Klayra”, the instructions for use must be studied. It is also advisable to take analogues as prescribed by a doctor.

An overdose can cause the development of the following symptoms:

• nausea;
• vomit;
• spotting not associated with menstruation.

In the first few hours after taking the tablets, it is recommended to perform gastric lavage and prescribe symptomatic treatment. There is no antidote to the product.

special instructions

1. The risk of thromboembolism and thrombosis (arterial and/or venous) increases: in smokers, with age, in the presence of arterial hypertension, obesity, family history, migraine, dyslipoproteinemia, extensive surgery, atrial fibrillation, heart valve disease, prolonged immobilization.
2. The greatest likelihood of venous thromboembolism (VTE) occurs in the first year of taking Qlaira, mainly during the first 3 months. Thrombosis of other blood vessels (for example, mesenteric, hepatic, renal) develops extremely rarely when using the drug.
3. In some cases, while taking the drug, the development of benign or malignant (in extremely rare cases) liver tumors was observed. If severe pain occurs in the upper abdomen, an increase in the size of the liver, or signs of intra-abdominal bleeding appear during differential diagnosis, it is necessary to exclude liver tumors.
4. When assessing the benefit/risk ratio, it should be taken into account that treatment of the relevant condition may reduce the associated risk of thrombosis. It is also necessary to take into account that the risk of thromboembolism and thrombosis during pregnancy is higher than when taking Qlaira.
5. The drug does not protect against sexually transmitted diseases, including HIV infection (AIDS).
6. If a persistent, clinically significant increase in blood pressure develops while taking the drug, Klaira should be discontinued and therapy for arterial hypertension should be started. After normalization of blood pressure, the drug can be resumed.
7. Before starting to take Qlaira, you need to carefully evaluate contraindications to its use based on the woman’s life history and family history, as well as a gynecological and general medical examination. The nature and frequency of these examinations should take into account the individual characteristics of the woman.

Patients who experienced episodes of dizziness and difficulty concentrating in the first 3 months of taking the drug (during the adaptation period) should be careful when driving.

Cancellation of contraceptives before pregnancy

Many women are very afraid of the consequences of stopping birth control pills and, despite the discomfort and desire to quit, continue to buy new packages of the drug.
As a rule, it is best to discontinue hormonal oral contraceptives after finishing taking the last pill from the pack, after which the woman should begin menstrual-like bleeding, or so-called withdrawal bleeding.

In order for the female body to respond as painlessly as possible to the withdrawal of drug treatment, certain rules should be followed:

• Be sure to consult with a gynecologist (there are situations when canceling treatment is strictly contraindicated, as this will lead to a deterioration in the general condition);
• Take tests to determine the level of sex hormones in the body;
• Finishing the started pack - abruptly stopping the drug in the middle of the cycle - is a big stress for the reproductive system and the uterus will most likely react with heavy bleeding, there will be a kind of withdrawal effect.

It is important to understand that oral contraceptives are a hormonal drug and using them independently without prior examination and consultation with a doctor increases the risk of complications.

Of course, it is advisable to finish the package of tablets to the end if you decide to stop using OCs and minimize negative reactions, but in some cases a woman urgently needs to stop taking it. Such situations include:

• Suspicion of pregnancy;
• Development of thrombosis;
• Detection of malignant neoplasms;
• Development of liver diseases;
• Diabetes;
• Arterial hypertension.

After abrupt withdrawal of the drug, a woman should be regularly examined by a gynecologist, since in such situations the risk of developing serious complications increases.

Many women are concerned about the question of whether it is possible to get pregnant after stopping the OC and how long after they should plan to conceive. If a woman decides to plan a pregnancy and stops taking birth control pills, then the body needs time for the menstrual cycle to fully recover; for this you should wait 2-3 months.

During the use of OCs, the ovaries were in a state of “sleep” for a long time, therefore it is recommended to wait a certain period for their physiological function to resume. Of course, conception can occur immediately after stopping the pills, but such a pregnancy will be at risk, since there is a high chance of spontaneous miscarriage due to progesterone deficiency in the expectant mother’s body.

Many women worry that after prolonged use of oral contraception, pregnancy becomes more difficult, but medical practice refutes this fact. On the contrary, for women with ovarian hypofunction, gynecologists prescribe the use of OCs for 2-3 months, after which they recommend planning a pregnancy, since the chances of successful conception increase significantly, in addition, the chances of conceiving twins increase. After stopping the pills and actively planning pregnancy, conception occurs safely within 3-4 months.

Correct intake after childbirth or termination of pregnancy

After the birth of the baby and only if the woman is not breastfeeding, as well as after a spontaneous abortion that occurs in the second trimester, it is recommended to take pills on the 21st or 28th day. If there was contact with the opposite sex before starting the dose, and the start of the dose was missed, then it is better to check with a gynecologist before taking contraceptives and rule out pregnancy.

Only after this is it possible to take Qlaira contraceptives. Customer reviews say that the drug effectively helps protect against unwanted pregnancy even after an abortion in the first trimester. It should be taken immediately on the same day it was performed.

Dosage

The medicine is taken daily, according to the indicated dosage in the package, for 28 days. The tablet should be taken, without chewing, at the same time. Be sure to follow the dosage regimen described in the instructions.

If the dosage is not followed, nausea, vomiting, and spotting not associated with menstruation may occur. There is no specific antidote to the product. In case of overdose, somatic treatment is prescribed. Any analogues (“Qlaira”, “Regulon”, etc.) should also be taken in accordance with the recommendations. It is worth remembering that improper use of contraceptives can lead to various horological disorders.

It is undesirable to take the drug "Jess" with certain types of antibiotics, barbiturates, rifampicin, and products containing St. John's wort. If a woman suffers from chronic diseases and is forced to constantly undergo drug therapy, she should definitely inform the gynecologist about this at the first appointment. You should stop taking contraceptives if you are planning a pregnancy.

Price

The cost of the drug depends on the manufacturer and the number of tablets in the package. So, an ordinary pack of Qlaira containing 28 tablets from the manufacturer Bayer Pharma (Germany) costs 1000-1100 rubles, from the German company Bayer Schering Pharma 950 rubles. Tablets, packaged in 84 pieces and designed for long-term use, produced by these companies, can be purchased for 2800-3350 rubles.

For comparison, it’s worth giving the prices for the main Qlaira substitutes:

• Jess - 1085 rubles;
• Yarina - 1120 rubles;
• Dimia – 660 rubles;
• Logest – 829 RUR:
• Janine - 1065 rubles;
• Visanne – 3325 rub.

Observation When prescribing oral contraceptives, the doctor takes into account not only clinical indications and test results, but also the financial capabilities of the patient. Qlaira is included in the middle price category, therefore it is considered not only effective, but also a relatively affordable drug compared to analogues.

The influence of Klaira on the course of endometriosis

The drug Qlaira belongs to three-phase low-dose oral contraceptives.
The amount of hormones in the drug varies depending on the phase of the menstrual cycle. The main components are estradiol valerate and dienogest. Unlike other contraceptives, the estrogen contained in Qlaira is identical to natural, which means the side effects are less pronounced.

During the treatment of endometriosis, Qlaira helps reduce pain and the volume of bleeding, which is especially important for severe anemia. Read more about taking OCs for endometriosis.

Instructions for use

The instructions for use indicate that Qlaira tablets are taken orally, washed down with water or other liquid if necessary, regardless of meals. The drug must be taken every day (continuously) 1 tablet per day at approximately the same time in the order indicated in the calendar for 28 days, after which the tablets from a new package begin to be taken.

As a rule, menstrual-like bleeding begins while taking the last tablets of the calendar pack. For some women, they begin after starting to take pills from a new package. If a woman has not used hormonal contraception before, Qlaira should be taken on the first day of the natural menstrual cycle.

When switching from another combined hormonal contraceptive, Qlaira should be taken the next day after taking the last active pill (containing the active substance). When using a transdermal patch or vaginal ring, you should start taking Qlaira on the day of their removal.

The transition from the use of the mini-pill can be made on any day, from the injection method - on the day of the next injection, from the intrauterine system with progestogen release or implant - on the day of their removal. During the first 9 days of taking Qlaira, it is recommended to use an additional barrier method of contraception.

After an abortion performed in the first trimester of pregnancy, Qlaira can be used immediately without the use of additional contraceptive measures.

After an abortion performed in the second trimester of pregnancy and after childbirth, the drug should be taken on days 21-28. If taking Qlaira is started later, during the first 9 days you should use an additional barrier method of contraception. In cases where sexual intercourse has already taken place, pregnancy should be excluded before starting therapy or wait until the onset of the first menstruation.

Depending on the day on which a woman missed taking 1 tablet for more than 12 hours, the following rules should be followed:

• Day 1-2 (dark yellow tablets): the missed tablet should be taken immediately, and the next one should be taken as usual (even when taking 2 tablets in one day);
• Days 3-7 (pink tablets): for the next 9 days you need to use additional contraceptive measures, continue taking the tablets according to the usual regimen;
• Days 8-17 (pale yellow tablets): additional contraceptive measures must be used for the next 9 days;
• Days 18-24 (pale yellow tablets): you should immediately start taking the drug from a new calendar package (from the first tablet), and additional contraceptive measures should be used for the next 9 days;
• Day 25-26 (red tablets): the missed tablet should be taken immediately, and the next one at the usual time (even when taking 2 tablets in one day);
• Day 27-28 (white tablets - placebo): you need to continue taking Qlaira according to the usual regimen, throwing away the missed tablet.

It is allowed to take no more than 2 Qlaira tablets in one day.

The more tablets (during the period from 3 to 24 days, especially those containing a combination of two active components) were missed, and the closer the day of the missed dose to the phase of taking inactive tablets, the greater the likelihood of pregnancy (in cases where within 7 days before missing the pill was sexual intercourse).

If there is no menstrual-like bleeding at the end of the current calendar pack/at the beginning of a new calendar pack, the possibility of pregnancy should be considered.

Absorption of the active substances of the drug in severe gastrointestinal disorders may be incomplete, so it is recommended to use additional contraceptive measures.

In cases where vomiting develops 3-4 hours after taking a tablet containing the active substance, the recommendations regarding missed tablets apply. If a woman does not want to change her usual regimen for taking Qlaira, she needs to take the appropriate additional tablet(s) from the new package.

Qlaira should not be taken by women after menopause.

Treatment regimen during menopause

The tablets are taken daily according to the schedule indicated on the package. It is recommended to take the capsules at the same time for 28 days. To control treatment with Qlaira during menopause, the instructions for use contain a special book with stickers indicating the day of the week. Indicating the first day of therapy allows you to avoid missing the next pill dose.

If a woman still has her period, treatment begins on the first day of the cycle. In cases where other COCs have previously been used, the contraceptive is taken the next day after the last oral contraceptive without taking a break.

If Qlaira was prescribed for menopause, how to take COCs if other contraceptives were previously used? When switching from gestagen-containing drugs (mini-pills, IUDs), for the first 9–10 days it is necessary to use additional contraceptive measures to protect against unwanted gestation.

If you miss taking an active tablet, take the next one as soon as possible, and use the remaining capsules according to the prescribed regimen. Placebo omission can be ignored. An interval of less than 12 hours does not reduce the effectiveness of Qlaira; with a longer interval, the risk of gestation increases. You are allowed to take no more than 2 tablets per day. You can stop treatment with COCs at any day.

During hormone therapy, women are recommended to undergo a medical examination at least once every six months. The doctor monitors blood pressure, the condition of the mammary glands, cervical uterus, pelvic and abdominal organs.

Klaira and pregnancy

Most women are afraid to take Qlaira as a treatment for endometriosis and other diseases. They motivate this by problems with conceiving a child in the future. Gynecologists say that pregnancy can still be expected after stopping the drug.

Is it possible to get pregnant while taking Qlaira?

The risk of accidental pregnancy is possible in some cases:

• after missing one tablet with the active substance and the absence of additional contraceptive measures,
• in case of violation of the calendar use of “Klayra” according to the instructions.

In these situations, pregnancy occurs due to the fact that the woman has poorly studied the rules for using contraceptives. If you follow all the manufacturer's recommendations according to the instructions, pregnancy will not occur while using Qlaira.

Pregnancy after taking Qlaira

The instructions for COCs warn that pregnancy after discontinuation of the Qlaira contraceptive may occur in the next menstrual cycle. However, some women find it difficult to become pregnant even after stopping the drug.

This is due to the fact that the active substances suppress ovulation, while the ovaries can remain in an inactive state for a long time, which prevents the possibility of becoming pregnant. Sometimes gynecologists, on the contrary, prescribe COCs to increase fertility and after stopping the drug, pregnancy still occurs.

Klaira in the postmenopausal period

The use of Qlaira for menopause after 50 years is recommended for the following purposes:

• maintaining bone mineral density, preventing fractures;
• therapy for pathological bleeding;
• prevention of endometrial hyperplasia, anemia;
• relief of vasomotor disorders;
• prevention of cysts, ovarian, endometrial, rectal cancer.

COCs can be used for 2 years after the last menstrual period in women under 50 and for 1 year after 50 years. Treatment in postmenopause is carried out in long courses for more than 6 months.

What can be replaced

There are no hormonal drugs similar in composition (dienogest + ethinyl estradiol) on the pharmaceutical market.

If the patient is unable to purchase Qlaira, the gynecologist may prescribe one of the drugs included in the same drug group (estrogens, gestagens and their combination):

• Angelique;
• Jess;
• Diana-35;
• Janine;
• Logest;
• Regulon;
• Silhouette;
• Yarina.

It is forbidden to replace one product with another when treating endometriosis on your own! Only a doctor, after examining hormones, can determine which substances in the tablets are suitable for a particular patient and will not aggravate the course of the disease, but, on the contrary, will provide a positive therapeutic effect.

Failure of the menstrual cycle with Klaira

The drug can cause disturbances in a woman’s menstrual cycle. Especially if it was not stable before. What can be understood in this case as a failure of menstruation:

• long delay;
• the onset of menstruation ahead of schedule.

Also, a delay in menstruation may be due to a gynecological disease, in which case the drug will act as a catalyst for this type of failure.

If, when using Qlaira, menstruation comes ahead of schedule, this happens for the following reasons:

• addiction to the drug (it lasts for the first 3-4 months);
• breakthrough bleeding (occurs in every cycle), in this case you need to consult a doctor, most likely the drug will have to be discontinued or replaced with another.

Experts also prescribe this remedy for the treatment of endometriosis. The disease is characterized by changes in the uterine mucosa and an increase in the number of endometrial cells.

Forms of the disease:

• genital (ovaries and fallopian tubes are affected);
• extragenital (the abdominal organs are affected).

Due to the high content of dienogestan, an analogue of progesterone, Klaira copes well with foci of the disease. However, Qlaira should be used with caution for endometriosis, since the estrogen analogue contained in this drug provokes the development of the disease. As a rule, Qlaira is prescribed at the initial stage of the disease. The results will be noticeable within six months.

What's better

After prescribing Qlaira, many women wonder whether the pills are really effective in treating endometriosis, and whether there are better hormonal treatments? For example, the drug Janine, which is also popular, contains 0.03 mg ethinyl estradiol and 2 mg dienogest.

You need to drink this monophasic remedy for 21 days of the cycle, after which you take a week-long break, during which your period begins. Despite the continuation of bleeding, on the 8th day a new package begins. The composition of the contraceptive Silhouette is similar.

All three products contain dienogest, Qlaira is used without interruption, and the tablets themselves contain different amounts of hormones. The volume of the substance in them varies - in the first pills it is absent, the subsequent ones include 2 and 3 mg. It is impossible to say which drug is better; it all depends on the patient’s hormonal status and the severity of endometriosis symptoms.

Visanne, unlike Qlaira, does not contain estrogen, which is considered an advantage when there is an increased volume of the substance in a woman’s body. The therapeutic effect of the tablets is due to a decrease in estrogen levels and an increase in gestagens (due to the presence of dienogest at a dose of 2 mg). The drug is taken without interruption, inhibits ovulation, but does not belong to the group of contraceptives.

Regulon is also often prescribed for endometriosis. It contains ethinyl estradiol 0.03 mg and desogestrel 0.15 mg, reduces the production of gonadotropin, which is responsible for the increased production of estrogen in the body. Thanks to taking the pills, ovulation is inhibited, the volume of endometriotic lesions is reduced, and the production of pain mediators is blocked. Doctors consider the drug effective, but which is more suitable, Regulon or Qlaira, depends on the results of hormone tests, the woman’s age, the stage of endometriosis and other factors.

Action of Qlaira during early menopause

The combined oral contraceptive contains a synthetic analogue of estrogen, estradiol valeriat, which is responsible for the condition of epithelial tissues, metabolic processes in the body, increasing libido, and strengthening skeletal bones. And also in combination there are gestagen analogues - dienogest. The active substance prevents the development of hyperplasia and atrophy of the endometrium of the uterus during menopause, and increases local immunity of the reproductive organs.

Composition of one package (28 tablets):

• 2 dark yellow capsules containing 3 mg of estradiol valerate;
• 5 red tablets of 2 mg dienogest and estradiol each;
• 17 light yellow tablets of 2 mg estradiol and 3 mg dienogest;
• 2 dark red tablets containing 1 mg estradiol;
• 2 white placebo tablets.

During menopause, Klaira slows down the atrophy of the uterus and vaginal walls and has a beneficial effect on the epithelial layer. The active components of the drug help reduce the level of bad cholesterol in the blood and protect blood vessels from the formation of atherosclerotic plaques.

Premature menopause can occur after 35–40 years of age. In this case, the menstrual cycle is disrupted, metrorrhagia appears irregularly, the volume of bleeding increases or decreases, and other symptoms of hormonal changes in the body appear. In women, reproductive function fades, and the chance of conceiving a child is significantly reduced.

In case of early menopause, Qlaira allows you to delay the onset of menopause, normalize the cycle, prevent the development of complications (osteoporosis, endometrial hyperplasia, cancer), relieve the symptoms of PMS, menopause. Treatment with COCs preserves the reserve of active eggs and gives a chance of conception after completing the course (3–6 months).

How does Qlaira work?

The instructions for use of the medicine state that Qlaira has a beneficial effect on the endometrium. This property makes it possible to use “Klayra” for the treatment of endometriosis, ovarian cysts, and adenomyosis. The composition contains the following components:

• estradiol valerate,
• dienogest.

To understand how the medicine works, it is worth understanding the effect of each of the components of the “Klayra” composition on the female body. Estradiol valerate stimulates the development of the uterus, eliminates disorders of the reproductive system when its function is insufficient. This component helps alleviate hot flashes, irritability and promotes recovery after ovarian surgery.

Dienogest replenishes the amount of female sex hormones when they are deficient. It is a component of antiandrogenic activity. When it enters the uterus, the substance binds to progesterone receptors, producing a powerful effect. In this case, the combination of two components can prevent the production of gonadotropic hormones, which leads to the impossibility of conception.

OC withdrawal syndrome: adverse effects

In the case when a woman was prescribed oral contraceptives for the treatment of diseases of the reproductive organs and the establishment of the menstrual cycle (fibroids, endometriosis, algodysmenorrhea, uterine bleeding, etc.), the so-called withdrawal syndrome occurs when the drug is discontinued. In this case, signs of the disease may return and intensify.

During abrupt withdrawal of the drug, a woman may experience the following adverse reactions:

• Development of persistent depression;
• Skin rashes, acne;
• Excessive hair growth;
• Weakness and irritability;
• Changes in sexual desire;
• Development of breakthrough uterine bleeding;
• Strengthening the work of the sebaceous and sweat glands, as a result of which the patient’s hair becomes oily, acne and comedones appear on the skin;
• Headache;
• Nausea, vomiting.

If more than six months have passed since discontinuation of the OC, and withdrawal symptoms persist, you should consult a gynecologist.

Gynecologists say that if a woman felt well before starting to use the pills and during their use and took the drug solely to protect against pregnancy, then 2-3 months after stopping the use the body will function as before, that is, a complete recovery will occur.

What is the drug

The drug "Qlaira" is an oral combined low-dose contraceptive. The single-phase product is well tolerated by women and contains different dosages of hormones, which are represented by several types of tablets that differ in color. "Klayra" contains estrogenic and gestagenic elements. The package also contains a couple of inactive tablets, which allow you to take the product without interruption.

The contraceptive effect is due to the fact that ovulation is suppressed, the thickness of the cervical mucus increases, and the sensitivity of the endometrium of the reproductive organ to the blastocyst increases.

But “Klayra”, reviews of women over 40 years of age confirm this, not only acts as a contraceptive, but also helps reduce the intensity and duration of bleeding from the uterus, reduces unwanted manifestations of premenstrual syndrome and pain during menstruation. Taking a contraceptive can reduce the risk of developing certain gynecological pathologies and reduce the symptoms of hypertrichosis.

Effect of the drug

The combined contraceptive Qlaira is a low-dose oral tablet with progestin and estrogen components. Of the 28 pieces, 2 are inactive, so you can take the medicine without interruption. The contraceptive effect is achieved by suppressing ovulation, increasing the thickness of cervical mucus, and reducing the level of sensitivity of the uterine endometrium to the blastocyst (the initial stage of embryo development).

In addition to the contraceptive effect, the drug reduces the intensity and duration of menstruation, relieves the manifestations of premenstrual syndrome (PMS), and minimizes pain. The estrogenic component of the composition is estradiol valerate, which is an ester of human estradiol. It differs from mestranol and ethinyl estradiol in that it is more metabolically active but has less impact on the liver.

The gestagenic component dienogest has a pronounced effect on the endometrium; its structure is derived from nortestosterone, and has its characteristics and properties of a progestogen. Dienogest is not androgenic, but exhibits antiandrogenic activity. Properties of components and their pharmacokinetics:

1. Estradiol valerate is quickly absorbed by the intestinal mucosa and hydrolyzed in the liver to form estrone, estriol, estradiol and valeric acid. 95% of the dose takes part in metabolism. Estriol and estrone are metabolized to sulfate and glucuronides and penetrate into the cell to a limited extent. Estrogens are oxidized by liver cytochrome enzymes. 5% of the dose reaches systematic circulation, the rest is bound to globulin and albumin. The half-life is 1.5 hours, the terminal period is 13-20 hours. Excretion is carried out with urine and feces.
2. Dienogest - has 91% bioavailability, almost all of it is absorbed, circulates in the serum in combination with albumin (90%) and in free form. The half-life is 12 hours. The substance undergoes complete metabolism with the participation of liver cytochromes. Excretion is carried out through the kidneys. 86% of the hormone is eliminated in 6 days.

Contraindications

Qlaira should not be used if you have any of the conditions listed below. The drug should be discontinued immediately if any of these conditions develop for the first time while taking it:

• pregnancy or suspicion of it;
• bleeding from the vagina of unknown origin;
• migraine with focal neurological symptoms, incl. in the anamnesis;
• diabetes mellitus with vascular complications;
• pancreatitis with severe hypertriglyceridemia currently or in history;
• liver tumors (benign and malignant) currently or in history;
• identified hormone-dependent malignant tumors (including genital organs or mammary glands) or suspicion of them;
• liver failure and severe liver diseases (until normalization of liver function indicators);
• conditions preceding thrombosis (including transient ischemic attacks, angina) currently or in history;
• the presence of pronounced or multiple risk factors for venous or arterial thrombosis (including extensive surgery with prolonged immobilization, complicated diseases of the heart valve apparatus, uncontrolled arterial hypertension);
• thrombosis (venous and arterial) and thromboembolism currently or in history (including deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI), stroke currently or in history);
• hypersensitivity to the active substances or any of the excipients.

If any of the diseases/conditions/risk factors listed below currently exist, then the potential risk and expected benefit of using the drug Qlaira should be carefully weighed in each individual case:

• hypertriglyceridemia;
• other diseases in which peripheral circulatory disorders may occur (diabetes mellitus, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn's disease and ulcerative colitis, sickle cell anemia);
• hereditary angioedema;
• risk factors for the development of thrombosis and thromboembolism (smoking, obesity, dyslipoproteinemia, arterial hypertension, migraine, heart valve disease, cardiac arrhythmia, prolonged immobilization, extensive surgical interventions, extensive trauma);
• diseases that first appeared or worsened during pregnancy or against the background of previous use of sex hormones (for example, cholestatic jaundice, cholestatic pruritus, cholelithiasis, otosclerosis with hearing impairment, porphyria, pregnancy herpes, Sydenham's chorea);
• postpartum period.

Use during pregnancy and lactation

Indications for use are:

• oral contraception;
• treatment of heavy and prolonged menstrual bleeding without additional pathological conditions;

The drug should not be used during menopause.

Here are the contraindications mentioned in the instructions for the contraceptive Klaira:

• hypersensitivity to the drug;
• venous and arterial thrombosis, as well as deep vein thrombosis;
• myocardial infarction;
• stroke currently or if it has been suffered;
• migraine;
• diabetes;
• pancreatitis;
• severe liver disease;
• pregnancy;
• lactation;
• lactose intolerance;
• malignant tumors.

For all these conditions, taking Qlaira tablets is not recommended.

The drug is contraindicated during pregnancy. If pregnancy is already a fait accompli at the moment when Qlaira is already being used by the patient, then it is recommended to immediately stop using the tablets.

The drug can also affect lactation, since it can reduce the production of breast milk in a nursing mother and change its composition.

Contraceptive contraceptive "Jess"

This is a monophasic contraceptive for oral use, which has antiandrogenic properties. Available in the form of pink and white tablets. The drug contains ethinyl estradiol 20 mcg and drospirenone 3 mg.

• contraceptive method;
• acne treatment;
• severe form of premenstrual syndrome.

• thrombosis of various etiologies;
• diabetes;
• precursors of thrombosis;
• migraine;
• hypertension;
• renal and liver failure;
• pregnancy;
• lactation.

The same contraindications are typical for Qlaira tablets. Analogues have many similarities.

More information about the drug

Qlaira has serious differences from products of similar purposes due to its composition. The package, intended for use in one cycle, contains several types of tablets of different colors. Some contain estradiol and dienogest - hormones that suppress ovulation, in strictly calculated quantities. Some are “dummies”. Taking the latter is also necessary.

The dosage of substances, as well as the use of tablets by day of the cycle, are clearly defined and should not change. Proper use will provide a gentle but steady effect on the functioning of the reproductive organs. Therefore, menstruation changes its parameters during clearing. This property of the drug is used, among other things, to stabilize them.

Another feature of the product is that you can use the clair to move your periods. If, after finishing taking hormone-containing tablets, you do not drink “pacifiers”, but immediately take the next package, the level of hormones in the body will increase. Your period will be delayed by a few days.

Jess

The medicine is a low-dose contraceptive drug. Sold in tablet form , 28 pieces . The composition contains the main active components drospirenone, calcium levomefolate, and ethinyl estradiol betadex clathrate. In addition to them, there are also excipients such as crocscarmellose sodium, magnesium stearate, hyprolose, lactose.

The effect of the medicine is achieved through the work of active substances. It is they that suppress ovulation, which ensures a contraceptive result and an increase in the level of viscosity of cervical mucus.

The medicine is prescribed for the following conditions:

1. To regulate the menstrual cycle.
2. For painful menstruation.
3. For contraceptive effect.
4. For the treatment of severe acne.

There are a number of contraindications for which the use of the drug is not recommended. Among them:

• Sensitivity to components.
• Thrombosis and tendency to it.
• Migraine.
• Diabetes.
• Severe liver and kidney diseases.
• Heart failure and other severe heart diseases.
• Malignant tumors.
• Bleeding of unknown origin.
• Lactose intolerance.
• Pregnancy and natural feeding.
• Children under 18 years of age.

Some patients report side effects. The most common among them are:

• Decreased libido.
• Bleeding and spotting.
• Headaches and dizziness.
• Nausea, vomiting.
• Mood changes.
• Depressive disorders.
• Various tumors may appear.
• Liver dysfunction.
• Allergic reactions.

If these side effects occur, it should be remembered that gradually the body adapts to the doses of hormones taken and the side effects will decrease.

The drug is actively absorbed by the intestinal walls, but if a woman has vomiting or severe diarrhea, the contraceptive effect may be reduced.

The medicine is sold by prescription. You can find it in pharmacies for about 1,000 rubles per pack.

Opinion of gynecologists

Today, many doctors prescribe birth control pills to plan pregnancy and normalize the menstrual cycle. Qlaira is very popular because it consists of the most important hormones. Pregnancy may occur while taking the drug, in which case it should be stopped immediately. In most cases, after several months of taking this remedy, the menstrual cycle is completely normalized. A very important point is strict adherence to the recommendations given by the attending physician.

See also: Novigan for menstrual pain reviews

Qlaira is a very popular contraceptive. The drug is designed to stabilize the general condition of a woman’s body. Klaira has a number of features, which most often manifest themselves in the absence of menstruation. With long-term and correct use of the pills, the menstrual cycle improves and the reproductive system returns to normal.

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pharmachologic effect

After taking Qlaira, two processes in a woman’s body are regulated: ovulation and the formation of cervical mucus. That is, this drug is able to suppress ovulation and change the properties of mucus, and also reduces the sensitivity of the inner lining of the uterus to a fertilized egg, which subsequently leads to an obstacle to pregnancy.

Thanks to its properties, it helps eliminate pain and the duration of menstrual bleeding. As a result of this, the woman’s body loses less blood, iron levels are normalized, which leads to a stable hemoglobin level and improved well-being. Qlaira is indicated for pain during the menstrual cycle.

The drug relieves increased pain and reduces heavy bleeding. The drug can not only provide a contraceptive effect, it can also reduce the risk of anemia, ectopic pregnancy, infectious and inflammatory diseases of the pelvis.

The tablets can also prevent the development of ovarian cancer, endometrial cancer and ovarian cysts. When taking the drug correctly, the possibility of pregnancy is almost excluded. It is worth noting that birth control pills are not used as protection against infectious diseases that are sexually transmitted.

No periods after taking Qlaira: reasons

Some women note that after drinking the first package they do not have periods. Don’t worry, hormonal changes in the body occur over the course of three menstrual cycles. But if there is no menstruation within 2 cycles, pregnancy must be ruled out.

While taking Qlaira in the middle of the menstrual cycle on the 14th day, spotting may appear, or your period may start earlier, for example, on the 20th tablet.

Other systems may react:

• thrush;
• painful sensations and slight enlargement of the mammary glands;
• dizziness, headache, mood swings;
• nausea, flatulence, diarrhea or constipation;
• increased blood pressure, hot flashes;
• weight gain;
• allergic skin rashes, itching;
• dyspnea;
• increase in body temperature.

In most cases, everything goes away after three months. If there is a pronounced deterioration in your general health, seek additional advice and they will select another method of contraception for you.

If pregnancy occurs while taking Qlaira, then stop taking the pills immediately.

It is impossible to say with 100% certainty that the drug had no effect on the embryo. But many studies have shown that the number of congenital anomalies of the fetus with Qlaira and without taking a contraceptive is not fundamentally different.

Note!

Do not prescribe or discontinue the drug yourself, only after consulting a doctor.

Vladlena Razmeritsa, obstetrician-gynecologist, especially for Mirmam.pro

Side effects from taking COCs

In the first months of taking the contraceptive, adaptation to the drug occurs. At this time, there may be spotting and spotting from the genital tract. They usually occur in the middle of the cycle and go away on their own within a few days. Breakthrough bleeding, requiring discontinuation of the drug, is less common.

It is also useful to read: Degrees of development of endometriosis

In the first months of use, there may be other reactions:

• Nausea, vomiting, abdominal discomfort;
• Tension and soreness of the mammary glands;
• Changes in mood, depression;
• Headache.

Such symptoms persist for 2-3 months, after which the body gets used to the influence of hormones and the condition improves. If there is no change, you need to change the drug.

Other undesirable reactions may occur throughout the course of treatment:

• Attacks of dizziness, migraine-like headaches, increased nervous excitability and irritability;
• Decreased mood, insomnia, suppressed sexual desire;
• Dry conjunctiva and intolerance to contact lenses;
• Abnormal bowel movements, abdominal pain, nausea;
• Dry skin, dermatitis, acne;
• Increased appetite and weight gain;

One of the side effects of taking Qlaira may be increased appetite.

• Increased blood pressure, deterioration of the veins;
• Functional ovarian cysts.

If unwanted symptoms appear, you should consult a doctor. Some reactions are not dangerous and go away on their own, while others require changing the drug.

Analogues of the drug Qlaira

Analogs of estrogens and gestagens include:

1. Femaflor.
2. Non-Ovlon.
3. Egestrenol.
4. Trigestrel.
5. Tri-regol.
6. Silest.
7. Individual.
8. Angelique.
9. Janine.
10. Midiana.
11. Rigevidon.
12. Klimonorm.
13. Diecyclen.
14. Dimia.
15. Femoden.
16. Climodien.
17. Silhouette.
18. Trisequence.
19. Cliogest.
20. Eviana.
21. Femoston.
22. Miniziston 20 fem.
23. Euro.
24. Triaclim.
25. Pauzogest.
26. Lindinet 30.
27. Triquilar.
28. Mercilon.
29. Gynodian Depot.
30. Oralcon.
31. Ovidon.
32. Diana is 35.
33. Anteovin.
34. Jess Plus.
35. Divina.
36. Yarina.
37. Logest.
38. Klymen.
39. Dailla.
40. Divitren.
41. Belara.
42. Desmoulins.
43. Novinet.
44. Gynoflor E.
45. Marvelon.
46. Regulon.
47. Zoely.
48. Microgynon.
49. Tri-Mercy.
50. Jess.
51. Cyclo-Proginova.
52. Lindinet 20.
53. NuvaRing.
54. Genetten.

Contraceptive "Yarina"

The medicine belongs to monophasic contraceptives with antiandrogenic action. Available in the form of light yellow tablets coated with a protective coating. The main components of the drug are ethinyl estradiol 30 mcg and drospirenone 3 mg.

The tablets are considered low-dose, combined, monophasic oral contraceptives. Their main property is to increase the viscosity of cervical secretion and suppress ovulation. In patients taking this drug, the menstrual cycle normalizes, bleeding decreases, and pain goes away. Drospirenone, which is part of the drug, maintains normal weight, improves the condition of the skin and hair, and has antiandrogenic properties. If you need a cheap analogue of “Klayra”, “Yarina” is perfect. For one package of medicine you will have to pay about 450 rubles.

Reviews from doctors and patients

Golovchenko Irina, Stavropol

Advantages: I took Qlaira tablets for 6 months. Got rid of endometriosis. We are planning a child. Cons: Gained a little weight.

Abramova Irina, Moscow

The gynecologist prescribed a course of Qlaira against adenomyosis, everything was fine, the drug helped. One of the negative aspects was that I felt nauseous at the very beginning of taking the pills. There were heavy periods.

Polyak Vera Anatolyevna, gynecologist

An excellent drug in the treatment of endometriosis. Along with all hormonal contraceptives, there is a low negative impact. But you need to remember that there are some contraindications.

Nosova Katerina, Luga

I used the medicine as a contraceptive. Works great. There have been no unwanted pregnancies, I have been drinking for 4 months. Skin and hair have become more manageable. Sometimes I had a headache when the weather changed.

You can find many different drugs for contraceptive effect on the market. Among them are the quite famous Klaira and Jess. They are very effective not only for contraception purposes, but also for treating certain diseases in women.

General information

One package of contraceptives is presented in the form of tablets of different colors and compositions. The blister contains 28 pieces , of which two are dark yellow, red and white, five are scarlet and 17 are light yellow.

All of them, except white ones, include estradiol valerate as the main substance. Each color tablet contains a different amount of this element. The auxiliary components are:

• corn starch;
• lactose;
• magnesium stearate;
• povidone 25.

As for white tablets, they consist only of the listed additional components.

Combined oral contraceptives (COCs) can change the properties of cervical mucus and suppress ovulation. In addition to protecting against unplanned pregnancy, Qlaira has a positive effect on the course of the menstrual cycle: it reduces pain during menstruation and reduces the amount of bleeding. In addition, the drug is suitable for the prevention of ovarian cancer.

The shelf life of contraceptives is four years from the date of manufacture, subject to the following conditions:

1. Keep the drug in a dry and cool place.
2. The packaging must be sealed before use.
3. Do not store tablets in the car, on the windowsill or in the bathroom (heat and humidity lead to the destruction of the components of the medication).

The cost of the contraceptive ranges from 1000 to 1500 rubles per package. The price depends on the region of residence and the method of purchase (ordering from an online pharmacy may be cheaper than buying from a regular pharmacy).

Minuses

The disadvantage of the drug is the presence of estradiol in its composition. This substance can stimulate the activity of endometriosis foci, especially at stages 3-4 of the disease. For this reason, gynecologists try to prescribe a contraceptive to women with 1-2 degrees of pathology.

Another disadvantage of Qlaira is that the tablets must be taken in strict sequence. You can’t skip or swap pills.

Therapy with Qlaira does not allow the patient to be prescribed continuous use of a contraceptive in order to achieve the effect of artificial menopause. White capsules in the amount of 7 pieces are pacifiers and are taken to start menstrual bleeding. They do not contain a medicinal substance, which means that during menstruation the patient does not receive a therapeutic effect.

Side effects

In most cases, Qlaira tablets are well tolerated by patients. Sometimes patients experience the development of the following negative reactions during therapy:

• Thrombosis.
• On the part of the digestive canal - pain in the stomach, changes in stool, nausea, disturbances in liver function, inflammation of the pancreas, increased activity of hepatic transminases.
• From the nervous system - depression, severe headaches, exacerbation of migraines, decreased concentration, disorientation in space in rare cases, aggression, irritability, insomnia, decreased libido.
• Changes in blood pressure readings.
• Progression of varicose veins in individuals with a hereditary predisposition.
• Bloody vaginal discharge during sex, pain during intercourse.
• Enlarged and painful lymph nodes.
• Skin reactions - skin rash, acne, baldness, dry and flaky skin, increased greasiness of hair.
• From the reproductive system - complete absence of menstruation, breakthrough bleeding from the genital tract, soreness and increased sensitivity of the mammary glands, development of ovarian cysts, vaginal dryness, discomfort in the lower abdomen, galactorrhea (discharge of milk from the nipples).
• Changes in body weight, swelling.
• Benign neoplasms in the mammary glands.

Available Qlaira substitutes in tablets

Rigevidon (tablets) Rating: 146 Top

Analogue is cheaper from 791 rubles.

Rigevidon is also a hormonal contraceptive for systemic use and is sold in tablet form. It differs from the “original” in the set of active ingredients, since it uses ethinyl estradiol and levonorgestrel in amounts of 30 and 150 mg, respectively. In addition to oral contraception, it can be used for functional disorders of the menstrual cycle.

Tri-Regol (tablets) Rating: 114 Top

Analogue is cheaper from 748 rubles.

The action of Tri-Regol is based on the use of ethinyl estradiol and levonorgestrel. It is prescribed as an oral contraceptive and includes an extensive list of restrictions and contraindications, which includes more than 20 points.

Lindinet 20 (tablets) Rating: 140 Top

Analogue is cheaper from 610 rubles.

Lindinet 20 is a Hungarian-made analogue from the same pharmaceutical group as the above medications. Sold in cardboard packages of 21 tablets containing simultaneously two active ingredients.

Along with this drug, visitors are looking for:

"Novinet"

The medicine belongs to the group of single-phase contraceptives for oral use. Available in the form of yellow film-coated tablets. The main substances in the drug are ethinyl estradiol 20 mg and desogestrel 150 mcg. The medicine is packaged in blisters of 21 pieces each.

The drug has a beneficial effect on lipid metabolism, reduces the amount of menstrual flow and pain. During treatment, the skin becomes soft and acne decreases. Once inside, the drug is almost completely absorbed in the stomach. Half is excreted in feces and urine. “Novinet”, an analogue of “Klayra”, has this effect. Reviews about the drug can be heard mostly positive.

Scheme for using the drug for endometriosis

Qlaira contains 26 active tablets and 2 placebo tablets. This allows you to minimize the gap between taking hormones and prevent the growth of lesions.

The drug is prescribed from the first day of the menstrual cycle - the first day of bleeding. You must take the tablets strictly according to the regimen indicated in the instructions. You cannot change the order of taking the drug! The composition of the tablets is different, and only with consistent use can the desired effect be achieved.

The pills, including placebo, are taken continuously. When the pack is finished, you need to start a new one the next day.

Scheme for using Qlaira.

The course of therapy lasts at least three months. The maximum is not defined - a woman can take the drug for as long as needed. As long as the patient takes hormonal pills, she is protected from the progression of the disease. The medical literature indicates that you can take contraceptives until the age of natural menopause - 45-50 years.

It is important to know

You should not take Qlaira at the same time as other hormonal medications. You must first finish the contraceptive package to the end and only then switch to another means.

How dienogest suppresses endometriotic lesions

The therapeutic effect of the drug is associated with dienogest, which is part of it. Estradiol valerate only stabilizes the menstrual cycle, but does not treat endometriosis. On the contrary, many researchers believe that estrogens in COCs can provoke the growth of heterotopias and lead to the progression of the disease. But not all gynecologists agree with this statement. There is an opinion that estradiol in combination with dienogest is not dangerous - provided the dosage and dosage regimen are followed.

The mechanism of action of dienogest:

• Suppresses the growth of endometriotic lesions. Hybrid gestagen inhibits proliferation in altered tissues, suppresses local hormone production and triggers apoptosis - programmed cell death;
• Inhibits the development of the inflammatory process in tissues. Dienogest inhibits the release of prostaglandins and growth factors. It relieves pain and allows you to reduce the dosage of analgesics. In some cases, it is possible to do without additional prescription of non-steroidal anti-inflammatory drugs;
• Suppresses ovulation. Dienogest inhibits the synthesis of FSH and LH in the pituitary gland, prevents the maturation of follicles and the selection of the dominant one among them. No ovulation means no monthly changes in the endometrium, which means the lesions do not grow;
• Prevents the growth of new vessels around endometriotic lesions. Dienogest deprives heterotopias of nutrition, and they regress.

Endometrioid heterotopias begin to regress under the influence of dienogest.

It is assumed that dienogest can also influence the immunological mechanisms of the development of endometriosis, but this process has not yet been fully studied.

On a note

The clinical effectiveness of dienogest in Qlaira is comparable to the effect of strong hormonal drugs - agonists of gonadotropic hormones. However, unlike the latter, hybrid gestagen does not reduce the level of sex hormones to the point of artificial menopause and does not lead to the development of osteoporosis. It is better tolerated and reliably suppresses the growth of heterotopias.

During the course of taking Klaira, the following is expected:

• Reduction in the size of endometrioid lesions (according to ultrasound and other examination methods);
• Normalization of the menstrual cycle. Menstruation occurs regularly, becomes scanty and painless;
• Subsidence or complete disappearance of pain;
• Improving the general condition of a woman;
• Restoring fertility after discontinuation of the drug.

It is also useful to read: The use of physiotherapy for endometriosis

Advantages of the drug

Before starting use, the instructions for use must be thoroughly studied. From the annotation you can find out how Qlaira works and what negative properties the medicine has. A distinctive feature of the drug from other hormonal drugs is its multicomponent nature. Qlaira tablets contain estradiol valerate and dienogest. A three-phase contraceptive has a complex effect on women with endometriosis.

• Thanks to the dosed content of hormones in each tablet, it restores the regularity of the menstrual cycle.
• It blocks the functioning of the gonads, which leads to a decrease in the level of natural estrogens in the body - stimulators of endometrial growth.
• The absence of ovarian activity reduces the severity of premenstrual syndrome. Pain in the mammary glands goes away, mood swings are less noticeable.
• Controlling sex hormones helps reduce the duration of menstrual bleeding and reduce the volume of blood released.
• The contraceptive effect prevents unwanted pregnancy. With endometriosis, there is a high risk that implantation of the fertilized egg may occur outside the uterus. It is important to undergo treatment before conception.
• Under the influence of hormones contained in Qlaira tablets, the growth of endometriosis foci stops. Cells located in atypical places undergo reverse transformation. Benign ovarian tumors (endometriomas) stop increasing in size.

Qlaira also has a number of advantages for the female body in comparison with other drugs. The active ingredients of the drug have a minimum effective dosage.

The tablets are quickly absorbed and do not have a toxic effect on the liver. Oral contraceptive hormones are as close as possible to the natural substances produced by the female body, which explains the absence of negative reactions.

Claira

The medicine is sold in the form of tablets of 28 pieces. In total, the manufacturer offers five types of tablet forms in different shades. They differ in markings. The composition contains the main active substance estradiol valerate , as well as a number of excipients, such as lactose monohydrate, starch, talc, titanium dioxide, dye, macrogol and hypromellose.

The effect of the drug is divided into tablets. The first four tablets are active, each type containing different dosages of the hormone. The large package also contains two inactive tablets to avoid confusion during administration.

The medicine is used for the following conditions:

1. To regulate menstruation.
2. For irregular cycles.
3. For contraception.
4. For the treatment of severe forms of acne.

There are many contraindications for which this medicine cannot be used. Among them:

• Tendency or presence of thrombosis.
• Pregnancy and lactation period.
• Children under 18 years of age.
• The period after the birth of the child must be at least 6 months (even if the woman is not breastfeeding).
• Phlebeurysm.
• Severe blood diseases.
• Tendency or presence of pathologies in the functioning of the heart.
• Having had a stroke or heart attack.
• High or low blood pressure.
• Smoking women.
• Those suffering from alcoholism.
• Severe diabetes.
• Cancer diseases.
• Serious pathologies of the liver and kidneys.
• Gallstones.
• Severe hereditary diseases.

What patients and doctors say

Experts note that the contraceptives listed in this article have a reliable level of protection against unwanted pregnancy. Many patients managed to restore their hair structure and improve their skin with the help of tablets. The drugs are well tolerated and do not cause side effects. Contain a minimum number of contraindications. The drugs differ slightly in their composition, but have identical actions and antiandrogenic properties. If you couldn’t find the drug “Klayra” at the pharmacy, cheaper analogues are available in a wide range.

All tablets have a protective coating, which does not irritate the gastric mucosa and is quickly absorbed. Reviews from doctors indicate that the drugs not only have a contraceptive effect, but also have a beneficial effect on women's health in general. The medicine is especially helpful for endometriosis. Patients claim that the symptoms completely disappear after taking the contraceptive.

The described drugs can also be prescribed to girls who are not sexually active to eliminate hormonal disorders. The drugs are really very effective. But they should only be used on the recommendation of a specialist. Taking contraceptives incorrectly can lead to serious hormonal changes.

Last price update: 10.20.2019 (150+ cities and 12,000+ pharmacies)

Source of information about drugs - RLS Directory of Medicines©

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Qlaira (tablets) Rating: 141