Use with caution: list of contraindications and possible side effects of the drug Noliprel

Tinnitus, nagging pain in the back of the head, rapid heartbeat - all these are symptoms of high blood pressure that significantly complicate life.

Fortunately, modern pharmacology offers a fairly wide range of drugs that combat this problem. However, choosing from them is not so easy.

One of these medications is Noliprel, the contraindications and side effects of which will be discussed in detail in the article below. This, as well as detailed instructions for use, will help you make a decision.

Composition and indications for use

Noliprel is a drug with combined effects, since it contains two active substances at once. It is their combination that gives a powerful hypotensive effect:

• indapamide . It is a diuretic, that is, it removes excess fluid through the kidneys;
• perindopril . Has a vasodilating effect.

Therefore, the drug is used to lower blood pressure (diastolic and systolic), unless it is caused by other diseases. It is also prescribed for hypertension in patients with type 2 diabetes.

Noliprel - instructions

Our article consists of instructions for the drug Noliprel, including Noliprel Bi-forte, which is supplemented by information from medical journals, as well as reviews from visitors to our website about this medicine. The official instructions for use are written in detail, but are very complex and not understandable for patients.

We have tried to present the information conveniently so that you can quickly find answers to the questions that interest you.

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Release form

Noliprel is available in the form of oblong tablets in a white shell, in quantities of fourteen or thirty pieces, placed in polymer jars with lids:

1. Noliprel (2/0.625 mg);
2. Noliprel A (2.5/0.625 mg);
3. Noliprel Forte (4/1.25 mg);
4. Noliprel A Forte (5/1.25 mg);
5. Noliprel Bi-Forte (10/2.5 mg).

Noliprel Forte

Instructions for use

A study of the main characteristics of the drug Noliprel A forte according to the Instructions for Use also does not give reason to believe that this is some kind of super-effective drug compared to its non-forte counterparts. The same indications and contraindications for use, the same dosages and side effects as all medications containing perindopril.

When is it prescribed and when is it contraindicated?

The indication for use of Noliprel A forte is essential, that is, primary, as well as secondary hypertension. No other indications for the use of this medication are indicated in the instructions for use.

As for contraindications, their list is almost identical to the similar list for the drug Perindopril Indapamide and includes:

• during pregnancy and breastfeeding;
• tendency to angioedema (Quincke);
• individual sensitivity to the components of the drug;
• hypokalemia;
• severe renal or liver failure;
• untreated decompensated CHF;
• adolescence (up to 18 years).

Dosage

The recommended dose for antihypertensive therapy for essential (primary) hypertension is one tablet once a day. Since some studies have confirmed the negative effect of food on the ACE inhibitory property, it is recommended to take it before meals, preferably in the morning.

For hypertension occurring against the background of type II diabetes mellitus, the initial dose should be half a Noliprel forte A tablet in the same dosage regimen - 1 time per day before meals.

Good tolerability of the drug by such patients makes it possible to increase the dose to one Noliprel A forte tablet (5 mg).

The use of Noliprel forte A for the treatment of elderly patients is possible only under strict control of blood pressure and renal function.

Exceeding the dose

If the dose is significantly exceeded or a large amount of medication is accidentally taken, the following manifestations of overdose are possible:

• a sharp drop in blood pressure;
• against the background of severe hypotension, nausea, vomiting, convulsions and other symptoms may appear.

To treat an overdose, gastric lavage is used, taking large amounts of activated carbon, be sure to restore the water-electrolyte balance and take other measures.

Contraindications

Unfortunately, Noliprel has a number of contraindications associated with the effects of indapamide and perindopril on the body:

• pregnancy, especially the second and third trimesters;
• breastfeeding period;
• severe kidney disease;
• in case of individual intolerance to the drug or its individual components;
• low potassium levels in the blood;
• before reaching the age of eighteen;
• hemodialysis;
• hereditary or acquired Quincke's edema.

You should also be careful and take Noliprel A only under the strict supervision of a doctor in the following cases:

• angina pectoris;
• heart failure;
• systemic lupus erythematosus;
• scleroderma;
• depressed bone marrow hematopoiesis;
• small volume of circulating blood;
• liver dysfunction;
• hyperuricemia;
• gout;
• aortic valve stenosis;
• before anesthesia;
• constantly changing blood pressure;
• advanced age;
• after kidney transplant surgery;
• atherosclerosis.

Noliprel is not advisable for use by professional athletes, as it sometimes gives a false positive test during doping control.

Analogue therapy

Analogues of Noliprel include drugs of various forms, including Noliprel A Bi-forte. The above remedies differ in the dosage of active substances. The medicine refers to a combination of ACE inhibitors, perindopril, indapamide. The mechanism of its action is related to the properties of the active substances and their complex effect. Noliprel A Bi-forte is prescribed for essential hypertension.

It is administered orally twice daily. If the patient has severely impaired liver function, the drug is contraindicated. If the patient has a moderate dysfunction of the organ, then the dosage is not adjusted.

Taking the drug in large dosages can provoke water and electrolyte disturbances. Additionally, vomiting, nausea, drowsiness and hypertension may occur. During therapy with Noliprel A Bi-forte, the following adverse reactions may occur:

• ringing in the ears;
• anemia;
• AG;
• migraine;
• poor sleep;
• allergy;
• rhinitis.

Noliprel A Bi-forte is contraindicated if the patient’s body is hypersensitive to the medication or ACEI. Not prescribed for patients on hemodialysis and pregnant women. Noliprel A Bi-forte should not be taken together with medications containing lithium. Otherwise, toxicity will increase. If this combination of drugs is prescribed, constant monitoring of lithium concentration in the blood is indicated. During treatment with Baclofen, the effect of Noliprel A Bi-forte increases. A similar effect occurs when the drug in question is taken in combination with a tricyclic antidepressant.

While taking corticosteroids, the hypotensive effect of Noliprel A Bi-forte is reduced. The medication is not prescribed to diabetics, as the hypoglycemic effect may increase. Cytostatics and allopurinol in combination with Noliprel A Bi-forte increase the likelihood of leukopenia. You should not drink alcohol during treatment with Noliprel A Bi-forte.

Side effects

Although this drug is considered a relatively safe drug, it may cause side effects. And although statistics show that unpleasant symptoms occur no more often than 0.1–3% of cases, it is important to familiarize yourself with this information before using the drug. If they occur, you must stop taking the medicine and inform your doctor.

The drug Noliprel can cause the following side effects:

• heart and blood : excessive decrease in pressure, anemia, hypokalemia, discomfort with a sudden change in body position, various manifestations of heart rhythm disturbances;
• digestive organs : impaired secretion of the oral mucosa, feeling of nausea, vomiting, pain in the abdomen, diarrhea, constipation, angioedema, lack of appetite;
• sense organs: lack of taste in food, noise or ringing in the ears, blurred vision;
• central nervous system : increased fatigue, mood swings, headache, dizziness, convulsions, asthenia, insomnia or, conversely, drowsiness, foggy consciousness;
• respiratory organs : cough, difficulty breathing, shortness of breath, bronchospasm, runny nose, swelling of the vocal cords, laryngeal edema;
• skin and muscles: skin rashes, itching, purpura, deterioration in systemic connective tissue diseases, photophobia, spasm of muscle fibers, increased sweating;
• genitourinary system : disorders of the kidneys, acute renal failure, increased levels of creatinine and protein, problems with potency.

In representatives of the Negroid race, Noliprel A causes side effects much less often, but the drug itself has a weaker effect.

Noliprel and alcohol, the compatibility of which is negative, can cause significant harm to the body

Noliprel for blood pressure: patient reviews

Most patient reviews of Noliprel tablets confirm that this drug effectively lowers blood pressure. It usually helps keep blood pressure below 140/90 or even below 130/80 mmHg. Art. and thus reduces the risk of heart attack, stroke, and kidney failure. Noliprel often helps even in cases where other drugs are useless, and this justifies its relatively high price.

Galina Myuzukova

I am 41 years old, height 168 cm, weight 72 kg, until recently I was 79 kg. I have been taking Noliprel A Forte for hypertension for 3 years now. Recently I managed to lose weight, but after that the medicine began to work worse. Pain appeared in the heart area, and sometimes I felt dizzy. The pressure drops excessively. I’m deciding whether to switch to Physiotens, a weaker drug. Perhaps I will take Indapamide or perindopril (Prestarium) separately.

The powerful effect of Noliprel is confirmed not only by patients, but also by doctors in their informal reviews, as well as in studies, the results of which are published in medical journals. Problems that arise in patients with hypertension in connection with taking this medicine appear when patients do not follow the doctor's recommendations and/or the instructions for the drug.

Yuri Bystryakov

Noliprel kept my blood pressure well for 8 years. It practically did not rise above 130/90. Since last week I have been having regular headaches. I measured my blood pressure - 140/100-150/110, this in the morning after sleep. For some reason the medicine stopped working. The body has become accustomed to it or the health condition has worsened with age. Now I’m thinking: should I increase the dose of Noliprel or change to another drug? I am 47 years old and overweight. Office work, managerial, nervous.

Noliprel, like other pills for hypertension, should be taken constantly, every day, and not in courses or when you feel a surge in blood pressure.

Svetlana Shestakova

For several years I have been taking Noliprel A in the morning for hypertension. A couple of months ago, a friend (not a doctor) advised me to add Cardiomagnyl to it before bed. I am very pleased with the result. The pressure did not drop because Noliprel held it well. But it seems that magnesium and aspirin dilate blood vessels, facilitate blood flow through them, and therefore feel better. Perhaps the Noliprel + Cardiomagnil regimen will be useful to someone else.

Cardiomagnyl tablets contain very low doses of magnesium, so they are of little use. They also contain aspirin, which can cause stomach bleeding. The benefit of aspirin in reducing the risk of heart attack has not been proven, but the risk of bleeding has been convincingly confirmed by practice. Take magnesium with vitamin B6 in Magne-B6, Magnerot, Magnicum, Magvit tablets. Read more in the article “Magnesium is the main mineral in the diet for hypertension.”

People often complain of side effects because this drug lowers their blood pressure too much. In such cases, you may feel weakness, lethargy, fatigue, apathy, and lack of energy for work. This means that you need to switch to tablets with a reduced dosage of both active ingredients, which are part of the combination medicine. Or, if hypertension is mild, then Noliprel are too powerful tablets and you need to replace them with softer ones. Do not do this on your own, but consult your doctor.

Dmitry Zheludev

Noliprel is a powerful blood pressure pill, but not a panacea. I have been taking this drug every morning for a long time now - 2 mg of perindopril and 0.625 mg of indapamide in one tablet. For several years everything was fine, but now the pressure began to rise. I went to the doctor - he said to add more Nebilet. I followed the recommendation and it really helped. But I understand that this is a temporary measure. I decided to switch to a healthy lifestyle in order to give up medications. That's how I came to your site. Even the most expensive pills will not be able to lower your blood pressure forever. It's time to take care of your health.

Patients in their reviews often complain about the side effects of powerful combination medications for blood pressure, including Noliprel. Usually these side effects are unpleasant, but not so severe that you need to stop taking the pills. Moreover, they can and should be neutralized by switching to a healthy lifestyle.

As a result of normalization of blood pressure while taking the drug, headaches usually go away and consciousness becomes clearer. This makes you feel better than it gets worse due to side effects. A dry cough is common but is usually a psychosomatic symptom. That is, if patients did not know that perindopril, like other ACE inhibitors, causes a dry cough, then they most likely would not have had this side effect.

Overdose

It is very important to remember that under no circumstances should you prescribe Noliprel for yourself. This is a powerful and fast-acting medicine, so if the dosage is exceeded, not only unpleasant sensations are possible, but also death. There were no cases of drug overdose provided that all doctor’s recommendations were followed.

Independently replacing Noliprel with Noliprel A or Noriprel Bi-Forte can lead to the following consequences:

• severe decrease in blood pressure;
• dizziness;
• increased drowsiness;
• prostration;
• incoherent thinking;
• feeling of dry mouth and nausea;
• vomiting reflex;
• muscle spasms of the limbs;
• short-term loss of consciousness;
• very low heart rate;
• cold sweat;
• violation of water-salt balance;
• excessive urination or, conversely, its complete absence.

How to take Noliprel tablets?

The combination medicine is taken once a day. This is very convenient, especially for busy and distracted people.

If the doctor has prescribed Noliprel, how to take this drug before or after meals is a pressing question for many patients.

The official instructions do not provide an answer. It is only indicated that the medicine should be taken in the morning.

Doctors recommend using the medication before breakfast. It is advisable to take the tablets at the same time. Then the effect of treatment will be more pronounced and there will be no side effects.

As for the dose, the doctor first prescribes one tablet per day. But, if a month after the start of treatment the desired result is not obtained, Noliprel Forte is prescribed at a dosage of 4 mg of perindopril and 1.25 indapamide. Sometimes doctors prescribe other medications. For example, calcium antagonists are added. In this case, the dosage of the antihypertensive drug is slightly reduced.

If the dose is too high, the following symptoms are observed:

• nausea and vomiting;
• drowsiness;
• apathy;
• dizziness;
• weakness;
• bradycardia;
• convulsions;
• fainting;
• cold sweat;
• severe decrease in blood pressure;
• cessation of urine output or frequent urge to go to the toilet.

If such signs appear, you should immediately call an ambulance. And when you feel better, you need to make an appointment with your doctor to adjust the dosage.

You cannot select the dose of the drug yourself. After all, excessively reducing the dosage causes poor health. An overdose can lead to heart attack and death.

What to do?

If one or more of the above conditions occurs, you must urgently call an ambulance.
If it is impossible to call an ambulance for any reason or the wait is prolonged, the following actions should be taken:

1. rinse the stomach to get rid of any remaining drug;
2. drink activated charcoal or another substance that helps remove toxins from the body;
3. lie on your back and place a pillow under your feet so that they are in an elevated position, but not suspended.

The effect of one Noliprel tablet lasts twenty-four hours, so any additional intake of even a small part of it can lead to an overdose.

Adverse reactions and overdose

When ethanol enters the body at the initial stages and in small doses, just like perindopril, it dilates blood vessels. This means that the effects of alcohol and Noliprel overlap each other, enhancing the effect, leading to a sharp decrease in blood pressure. In addition, signs of a drug overdose may appear. However, following all medical recommendations for taking the medication and treatment regimen, no cases of overdose have been recorded over the entire period.

Read also: What alcohol can be added to coffee

With further absorption into the blood and increasing doses, ethanol begins to exhibit a diametrically opposite effect - the vessels narrow and the pressure rises. And then alcohol and Noliprel begin to act in different directions, and this is fraught with sharp uncontrolled jumps in blood pressure both up and down, arrhythmia and other disruptions in the functioning of the cardiovascular system. It is possible that side effects may occur or intensify due to the drug, including myocardial infarction and stroke.

Interaction with other drugs

Noliprel can interact with other medications, so its combined use with lithium-containing drugs is unacceptable. Otherwise, there is a risk of developing severe intoxication of the body.

You should be careful when combining therapy with the following substances:

1. Baclofen reduces Noliprel's ability to lower blood pressure;
2. NSAIDs can lead to impaired renal function, including renal failure, and there is a risk of developing hyperkalemia;
3. antidepressants and antipsychotics also reduce the hypotensive effect; in addition, discomfort and dizziness may occur with a sudden change in body position;
4. corticosteroids prevent the removal of excess fluid from the body, which reduces the effectiveness of the drug;
5. Any medications that increase blood pressure are antagonists and mutually neutralize the effect on the body.

Interaction of a medicinal product with alcoholic beverages

Any doctor will tell you that the drug Noliprel and alcohol are absolutely incompatible. This combination can lead to very serious consequences and even death of the patient.

First of all, alcohol has a very toxic effect on the main filter of the body, greatly increasing the load on it. Under the aggressive influence of ethanol, the liver is gradually destroyed. And if at this moment it is also affected by a drug that is also metabolized in the liver, then such increased work can completely disrupt its functioning and lead to cell death. The result of this interaction can be alcoholic hepatitis or cirrhosis of the liver.

Alcohol also has a negative effect on the central nervous system, and the side effects from taking Noliprel also expose it to severe depletion. In addition, under the influence of ethanol, all adverse reactions from taking the drug are significantly enhanced, which can lead to very negative and very disastrous consequences.

Alcoholic drinks significantly reduce the absorption of the drug, thus its concentration in the body is noticeably reduced, which weakens the therapeutic effect and can even neutralize all previous results of treatment with Noliprel.

Read also: Durian is not allowed with alcohol

Ethanol promotes the dilation of blood vessels, and perindopril, which is part of this drug, has exactly the same effect. Accordingly, their simultaneous use may provoke an increase in the effect of Noliprel, which can cause a sharp drop in blood pressure, as well as an overdose of the drug with all the ensuing consequences.

The table indicates the possibility of joint use of alcoholic beverages and the drug Noliprel - after how long and when to take the drug

• 32 hours before drinking alcohol for women.

• 14 hours after drinking alcohol for men.

• 20 hours after drinking alcohol for women.

• after 15 days if there was a course of treatment, for men and women.

[!] to avoid possible health risks, give up alcohol for the entire period of treatment.

• under no circumstances at any stage of pregnancy.

• under no circumstances during the course of treatment, for men and women.

If there is possible incompatibility, noliprel will affect heart rhythm disturbances - bradycardia or tachycardia, manifestations of acute heart failure, and sometimes orthostatic hypotension.

• Drink more water for the next 4 hours.

• In the annotation to the medicine, read the paragraph - contraindications, and follow them.

• If the medicine was taken as a course of treatment, alcohol is contraindicated for use from 3 days to 1 month (depending on the instructions of the attending physician).

• It does not matter what form of Noliprel is taken with alcohol, both the tablet and the ointment will have an effect.

• If this happens for the first time, the risk of harm to health is minimal.

• Contact your doctor for further help and advice.

— In the calculations of the table, the average indicator of alcohol consumption (average degree of intoxication) is taken, calculated in proportion to body weight of 60 kg.

— Alcohol that can affect the drug includes: beer, wine, champagne, vodka and other strong drinks.

— Even 1 dose of alcohol can affect the medicine in the body.

For 1 dose of drink for different drinks, it is generally accepted to consider:

Doctors in most cases require that alcohol be completely eliminated while taking powerful medications, which fully applies to Noliprel. But modern people often strive to understand the essence of a specialist’s instructions, and not just strictly follow them. Therefore, let us consider the main aspects of the issue of alcohol compatibility with the drug Noliprel.

Drug analogues and cost

Since Noliprel has a number of contraindications and a relatively high price (the average cost in pharmacies, depending on the form of release, ranges from 380 to 1200 rubles), your doctor may offer you therapy with its analogues.

Ko-Parnavel tablets

Analogues of Noliprel are:

• Perindopril-Indapamide, Richter;
• Indapamide Perindopril-Teva;
• Ko Parnavel;
• Perindapam;
• Ko-perineva;
• Perindid.

Since Noliprel contains two active substances that affect blood pressure, you can use a cheaper analogue that contains only one of them.

Brief characteristics of the drug Noliprel

The main active ingredients of this medication are perindopril and indapamide. The effectiveness of the drug is directly related to the combination of some positive effects of these substances. Noliprel is an antihypertensive drug that helps reduce arterial diastolic and systolic pressure. Its pharmacological effect is dose-dependent, that is, the larger the dose, the stronger the effect of the medicine on the body.

The medicinal component perindopril helps to significantly reduce blood pressure, has a pronounced vasodilator effect, significantly improves the condition of the arterial walls, and effectively reduces the load on the heart muscle.

Indapamide also significantly reduces hypertension and reduces the risk of occurrence and development of hypokalemia, reduces the hyperreactivity of blood vessels under the influence of adrenaline, and also reduces left ventricular hypertrophy. This component has no effect on lipid and carbohydrate metabolism in the body.

Taking this medication is not addictive and is not accompanied by an increase in heart rate. A sustained therapeutic effect of Noliprel is observed approximately a month after starting the drug. The duration of blood pressure stabilization is one day.

This medication is widely used for essential arterial hypertension, the primary form of a chronic disease that is not accompanied by secondary hypertension caused by various problems with internal organs and systems. Noliprel is prescribed if arterial hypertension occurs in the presence of non-insulin-dependent diabetes mellitus.

The main types of this drug include:

• Noliprel Forte is a drug with an increased dosage of the main active ingredients;
• Noliprel A - with the addition of arginine, which helps improve the functioning of the cardiovascular system;
• Noliprel A Forte is the previous drug with an increased dosage of the main active ingredients;
• Noliprel Bi Forte is the strongest and most popular drug of all of the above.

This medicine is available in tablets, which are usually taken once a day. The required dosage and type of drug should be prescribed by the attending physician, based on the individual characteristics of the patient and the severity of the disease. After a month and a half, the dose is usually adjusted depending on the results of therapy.

With minor changes in blood pressure, the dosage is usually increased or a drug that is stronger in composition and effect is selected. Often, instead of replacing a drug with a stronger analogue, another drug is prescribed in addition to the existing treatment, which will enhance the therapeutic effect. The potassium antagonist has proven itself to be most effective in this case.

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Video on the topic

This video discusses the drug for hypertension Noliprel. They tell who it is prescribed to and in what dosages:

Noliprel is one of the most powerful and fast-acting drugs for hypertension. Its main advantage is the need to take only one tablet per day, significantly reducing the risk of overdose, which is especially important for drugs of this type of action. At the same time, cases of side effects are extremely rare, which allows us to consider it a fairly safe remedy for lowering blood pressure.

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• Eliminates the causes of pressure disorders
• Normalizes blood pressure within 10 minutes after administration

To learn more…

How do blood pressure pills work?

I honestly tried to figure out the composition and carefully studied the available information on each component of the drug. Fortunately, there are only two of them, so you can describe these elements separately.

Perindopril is an inhibitor that converts angiotensin 1 into angiotensin 2. I understand that for many this is a meaningless set of letters. Now I’ll try to decipher the terms. The substance works on the principle of feedback, that is, if necessary, it expands or, conversely, constricts blood vessels, equalizing blood pressure. In reviews of people who have undergone treatment, Noliprel read that, if used correctly, the tablets have a positive effect on the heart, reducing pre- and afterload. All this thanks to perindopril.

Indapamide is considered one of the best diuretics. Such drugs inhibit the reabsorption of water and salts in the kidneys. Again, complex “gibberish” - in fact, everything is extremely simple. Noliprel accelerates the removal of fluid from tissues, while swelling disappears and the load on internal organs is significantly reduced.

That's the entire composition of the drug. A small number of components in the composition significantly reduces the list of contraindications. The description of the medicine states that it should not be taken if:

• renal failure;
• liver problems;
• pregnancy, lactation;
• hypersensitivity to the elements of the drug.

In the reviews I came across another feature of the product. It is very important to be as careful as possible for people suffering from lactose intolerance. This element is also included in Noliprel.

Are there any contraindications?

Noliprel tablets should be used exclusively as prescribed by a doctor, as they can provoke unwanted reactions and worsen the course of hypertension. It is not recommended to use the medication during pregnancy and while breastfeeding. Avoid treatment with Noliprel in the following cases:

This drug should not be prescribed to minor patients.

• allergic reaction to the components of the drug;
• glomerular filtration rate less than 30;
• severe potassium deficiency;
• signs or suspicions of encephalopathy;
• use of pharmaceuticals that prolong the QT interval;
• age less than 18 years;
• deficiency of lactose included in the drug "Noliprel".

Drug overdose

If the specified dose is significantly exceeded, the patient's body may experience a strong decrease in blood pressure and the manifestation of various side effects from the nervous system of the body - dizziness, confusion, a burning sensation, tingling or goosebumps, drowsiness, unstable mood.

In case of an overdose, the patient should be admitted to a hospital as soon as possible, where qualified doctors will prescribe a gastric lavage procedure, then introduce intestinal sorbent into the body and subsequently carry out the necessary therapy aimed at weakening or eliminating the unpleasant consequences of the overdose.

Distinctive features of Noliprel

Noliprel is a drug that has a hypotensive effect. This combination medication can lower both systolic and diastolic blood pressure. The strength of the effect on the body directly depends on the dosage taken.

Noliprel is a combination drug with antihypertensive effect

Before deciding whether it is possible to combine Noliprel and alcohol, it is worth considering the mechanism of action of the drug.

The medicine has the following properties:

1. dilates blood vessels;
2. improves the condition of arterial walls;
3. reduces the load on the heart;
4. relieves vascular hyperactivity;
5. prevents the development of hypokalemia;
6. protects blood vessels from the effects of adrenaline;
7. reduces left ventricular hypertrophy.

The drug does not affect lipid and carbohydrate metabolism in the human body. During treatment, patients do not develop addiction. Side effects are rare; heart palpitations were not observed due to taking Noliprel.

If treatment is carried out in courses, a sustainable therapeutic effect can be achieved. Within a month, patients' condition improves significantly and they are less dependent on the next dose of medication.

Active ingredients in the medicine

The compatibility of Noliprel and alcohol can be assessed by considering the chemical composition of the drug.

Perindopril is the structural formula of one of the active components of the drug Noliprel

The drug contains the following main active ingredients:

• perindopril arginine – 2.5 mg;
• indapamide – 0.625 mg.

In addition to the main substances, the composition contains the following compounds:

1. lactose;
2. magnesium stearate;
3. maltodextrin;
4. silica;
5. sodium starch;
6. macrogol 6000;
7. glycerol;
8. hypromellose;
9. titanium dioxide.

The tablets are coated. Absorption of both active components occurs quickly through the gastrointestinal mucosa. Within an hour, the maximum concentration of these substances is reached in the blood.

The half-life of perindopril is 1 hour, and indapamide - up to 14 hours. The bioavailability of both substances is higher when taking the medication on an empty stomach.

The active substances bind to blood proteins. Excretion occurs in urine and feces.

Noliprel is used for diseases associated with high blood pressure

When a doctor prescribes a medication for use, you should immediately discuss whether it is possible to take Noliprel and alcohol at the same time. This way you can protect yourself from an unfavorable reaction of the body.

Medical indications for use of the drug

Sometimes it is impossible to combine Noliprel and alcohol, not only because of the chemical reaction of ethanol and the components of the drug, but also because of health conditions. This drug is prescribed in the following cases:

• essential hypertension (uncomplicated);
• hypertension caused by diabetes mellitus.

It is necessary to stop using Noliprel if you have the following conditions and diseases:

1. pregnancy at any stage;
2. lactation;
3. high sensitivity to sulfonamides, indapamide, ATP inhibitors;
4. previous angioedema;
5. hypokalemia;
6. renal failure;
7. liver failure.

The drug should not be taken simultaneously with drugs that affect heart function and ECG patterns, in particular, with drugs that prolong the QT interval.

Combination of Noliprel and alcoholic beverages

When deciding whether to combine Noliprel and alcohol, it is necessary to consider what happens in the body with such a combination.

The use of the medication along with the consumption of alcoholic beverages leads to the fact that the medicinal components are not absorbed into the blood so quickly.

As a result, the treatment does not achieve the desired effect, and blood pressure decreases more slowly and by fewer units.

Doctors do not recommend drinking alcohol while being treated with Noliprel

At the same time, when ethanol enters the blood, blood vessels begin to dilate. This leads to a decrease in pressure. Depending on the state of the body and its individual reaction, the effect of the medication can either be suppressed or enhanced.

Drinking alcoholic beverages in large quantities may not lower blood pressure, but, on the contrary, cause a jump. A sharp increase often leads to long-term negative consequences.

Side effects from the combination

If you combine Noliprel and alcohol, the consequences may be different. This combination overloads the body, stresses the liver and upsets the nervous system.

Drugs with similar effects

If it is necessary to replace the drug, you can select an analogue whose quality corresponds to the quality of the original drug. Such substitutes are:

• Vitopril;
• Diroton;
• Zonixem;
• Lysigexal;
• Lisinovel;
• Linotor;
• Rileys – Sanovel;
• Scopril;
• Solipril.

The doctor selects the optimal analogue of the drug; self-medication can lead to undesirable consequences for the patient’s health and the occurrence of adverse reactions.

Indications and contraindications

The drug is prescribed to lower high blood pressure.
Taking the pharmaceutical drug is relevant for high blood pressure and hypertension of any severity, as well as as part of complex therapy in case of the inability of the heart muscle to pump the required amount of blood. Lipril is also effective as an adjuvant for acute myocardial infarction.

However, it is not always possible to use Lipril to reduce high blood pressure. The medicine is not suitable for persons with individual intolerance to its components, children under 18 years of age, pregnant and nursing mothers. It will be necessary to abandon Lipril in case of stenosis of the arteries of one of the kidneys, cardiogenic shock, and in the case of hereditary or idiopathic angioedema.

Additional Information

It is worth noting that the first dose of the medicine can provoke a sharp decrease in blood pressure - no need to be alarmed, this is normal, especially in the first few days. But such a patient must be under constant supervision of medical staff.

In addition, during therapy it is necessary to take tests from time to time - this helps to monitor the level of creatinine and potassium in the blood, since deviations from the norm are possible under the influence of the medicine.

Doctors also do not recommend driving during therapy or working with various mechanisms that require maximum concentration and quick reaction. Before starting treatment, be sure to tell your doctor about the medications you are taking, since Noliprel Forte in combination with other medications can be dangerous.

Drug overdose

When taking a dose that exceeds the maximum daily values, consequences occur, the symptoms of which appear at the level of functioning of different body systems:

1. Headache and severe dizziness (sphere of influence of the central nervous system).
2. Diarrhea, weight loss, hepatitis, nausea (gastrointestinal function).
3. Pain in the chest region, tachycardia, cardiac arrhythmia (CVS activity).
4. Uremia, impotence, renal dysfunction (genitourinary system).
5. Skin rash, angioedema (allergies, skin reactions).
6. Changes in blood parameters.

Liprin also affects the general condition of the body, provoking the appearance of sinusitis, arthralgia, shortness of breath, glossitis, and dry cough.

Noliprel instructions

It is a combination medication, its two active substances are listed above. Each of them has its own set of properties, thanks to their joint activity the drug is capable of:

• Influence the activity of renin in the blood;
• Reduce vascular resistance;
• Normalize the work of the myocardial muscle;
• Reduce aldosterone secretion;
• Reduces the effects of body overload;
• Reduces blood pressure;
• Increases cardiac output;
• Prevents left ventricle enlargement;
• Improves the elasticity of blood vessels.

The drug, despite its strong effect, does not affect the amount of cholesterol and lipids, does not participate in metabolic processes, and does not in any way affect the content of salts and fluids in the body. The action continues throughout the day. The desired effect, which remains for a long time, occurs within a month. After stopping its use, there is no addiction syndrome.

Noliprel is produced in the form of oval, oblong, white tablets with a line on both sides, which makes it easier to break the pill when you need to take half a dose.

Noliprel - indications for use

The drug is most often prescribed for essential hypertension to prevent the risk of microvascular complications in patients who suffer from this disease, as well as from diabetes.

The drug is most often prescribed for essential hypertension to prevent the risk of microvascular complications in patients.

Features of taking the medicine

This combination medication contains active substances that have a high level of impact on the body, so they are taken only once a day. This pill intake is ideal for older people who may forget how many pills were taken in a given time, as well as with I got up in the morning, took it, and don’t have to remember it all day.

It is better to take this drug in the morning, take it in one dosage for 5 weeks, then the doctor can adjust the dose of the medicine depending on how the treatment is going. If it is necessary to enhance the effect of the drug, then medications that act as calcium antagonists are prescribed together with it.

In cases where the pressure drops sharply, the doctor will reduce the dose.

In the first days of using Noliprel, you should refrain from driving a car and working on high-precision energized mechanisms, then you need to focus on your condition.

Taking medication during pregnancy and lactation

During the period of planning and bearing a child, it is better not to use Noliprel A, and if treatment was prescribed before, then you need to stop taking it and replace it with another drug.

It is better to take this drug in the morning, take it in one dosage for 5 weeks, then the doctor can adjust the dose of the medicine depending on how the treatment is going.

This medication has not been subjected to clinical studies of the effects of ACE inhibitors during pregnancy. But even if the drug was taken in the first trimester, it does not affect the development of the fetus in any way, but its fetotoxic effect has not been studied.

In the second and third trimester, Noliprel A is contraindicated. The components of the medicine may affect the development of the baby. It has a detrimental effect on kidney function, the formation of skull bones, and in a newborn there may be a slowdown in the healing of the “fontanelle”, the appearance of arterial hypotension and the development of renal failure.

To exclude the influence of a drug taken at the end of pregnancy, you need to undergo an ultrasound of the kidneys, and also check the condition of the newborn’s skull.

While breastfeeding, Noliprel is contraindicated, as it reduces the amount of breast milk and suppresses the lactation process. While taking this medication, the baby may develop jaundice, hypokalemia and sulfonamide.

If this drug is extremely important for the health of a young mother, then you may have to stop breastfeeding so as not to harm the baby.

Overdose

It causes water and electrolyte abnormalities in the body, which result in hyponatremia and hypokalemia. In addition, it is accompanied by the following symptoms:

• Drowsiness;
• Anuria and polyuria;
• Strong decrease in pressure;
• Nausea leading to vomiting;
• Decreased heart rate;
• Fainting;
• Cold sweat with chills;
• Convulsions;
• Dizziness.

Noliprel should not be taken if the patient has severe renal failure; as well as patients undergoing hemodialysis treatment.

Contraindications

Noliprel should not be taken if the patient has hypersensitivity to the drug. You should not take the drug for the following diseases:

• Severe form of renal failure;
• Patients undergoing hemodialysis treatment;
• In childhood;
• Hepatic encephalopathy;
• Those who have previously experienced angioedema after taking similar medications;
• Stenosis of the kidneys and their arteries.

Side effects

When treated with Noliprel, various adverse reactions of the body may develop from its different systems:

1. Genitourinary. Rarely, deterioration of kidney function and decreased potency occur. And if you take the drug together with other diuretics, you will get an excess of creatinine in both urine and blood.
2. Cardiovascular. It may respond to excess with orthostatic collapse, increased hypotension, rarely, but all this results in arrhythmia, myocardial infarction or stroke.
3. Digestive. Accompanied by vomiting, abdominal pain, cholestasis, drying of the mucous membranes of the throat, sometimes abdominal pain, bloating or constipation.
4. Nervous. Prolonged headaches occur, accompanied by dizziness, vision deteriorates, and sometimes ringing in the ears is heard, appetite decreases, convulsions appear, and slight inhibitions in reasoning and perception of what is happening.
5. Respiratory. Dry cough that does not last long, runny nose, difficulty breathing, spasms in the bronchi.
6. Blood Hyperglycemia, increased urea levels, pancytopenia, thrombocytopenia, hemolytic anemia and agranulocytosis.
7. Skin. In case of overdose, a rash appears on them as a result of allergic reactions, urticaria, hemorrhagic vasculitis and lupus erythematosus.

Taking Noliprel with other medications

We will display the compatibility of the drug with medications in tabular form.

The drug should not be taken together with alcohol, as its influence will only intensify the side effects.

Noliprel forte - analogues

Among the worthy substitutes for this drug are:

1. Accusid. It is used for patients who are prescribed complex treatment with a diuretic and quinapril.
2. Iruzid. Treats people with mild to moderate hypertension if they are stable on therapy.
3. Capothiazide. Used in conjunction with other antihypertensive drugs, it treats any form of arterial hypertension.
4. Quinard. Prescribed for chronic insufficiency and hypertension.
5. Co-renitec. Used for patients undergoing complex therapy.
6. Lisinopril/hydrochlorothiazide. The drug is intended for the treatment of mild to moderate hypertension.
7. Lizopres. Treats hypertension.
8. Liprazid. Created to cure any form of hypertension, including renovascular.
9. Mypril. Reduces blood pressure.
10. Rami compositum. It is a solution for those patients who cannot control their blood pressure with monotherapy.
11. Tritace. It is used both for complex treatment and can be used in conjunction with other calcium antagonists and diuretics. Helps with congestive heart failure.
12. Phozide. Prescribed for arterial hypertension.
13. Ena sandoz. It is used for essential hypertension, chronic heart failure, and for the prevention of heart attack.

Noliprel should be taken during normal dehydration of the body in order to avoid sudden hypotension. During its use, creatinine, electrolytes and blood pressure are monitored. If the patient suffers from heart failure, the drug should be combined with beta-blockers. It should be taken into account that Noliprel gives a positive reaction in doping tests.

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First aid

If a patient experiences symptoms of an overdose of Noliprel, it is necessary to immediately take measures to remove the drug’s metabolites from the body:

• infusion therapy,
• gastric lavage,
• enterosorbents,
• dialysis.

Accompanied by vomiting and abdominal pain

Side effects

During treatment of arterial hypertension with this medication, the following adverse events and pathologies may develop:

• vertigo, headaches;
• decreased hemoglobin levels;
• change in taste preferences;
• sleep disturbance;
• depression;
• noise in ears;
• confusion;
• myocardial infarction;
• muscle spasms;
• tachycardia;
• bronchospasm;
• dry cough;
• dry mouth;
• loss of appetite;
• frequent loose stools, constipation;
• nausea;
• gagging;
• rashes and itching of the dermis;
• psoriasis;
• hives;
• increased sweating;
• baldness;
• fever;
• arthritis, arthralgia, myalgia;
• deterioration of kidney function;
• impotence.

Mechanism of action

Taking the medication helps lower blood pressure.
After taking the drug, there is a suppression of the formation of agiotensin II and a decrease in the vasodilatory effect of the latter. There is a positive stimulation of the production of aldosterone by the adrenal glands. A patient taking Lipril experiences:

• reduction of total peripheral vascular resistance (TPVR);
• increase in minute blood volume;
• reduction of afterload;
• decrease in blood pressure in the pulmonary circulation;
• decreased blood pressure;
• increased blood flow inside the liver.

60 minutes after administration, the drug begins to have an effect on the patient’s body. The maximum concentration of substances is observed after 6 hours. The effect on the body lasts throughout the day. The positive thing is that even if you take Lipril for a long time, the effect on the body does not decrease.

After stopping the therapeutic course of Lipril, withdrawal syndrome is almost never observed.