How to take Lazolvan solution orally according to the instructions for use in the treatment of cough in children and adults?

For diseases of the respiratory system with characteristic wheezing in the bronchi and an unproductive cough, the therapeutic use of the drug Lazolvan (solution), which has secretolytic, expectorant properties, is justified.

Thanks to the active component of the drug, secretion in the respiratory tract increases, and increased production of bronchial surfactant helps stimulate the motility of the ciliated epithelium. All this leads to easier evacuation of mucus from the respiratory organs and their cleansing (called mucociliary clearance).

Since before using any medication, even if it is sold over-the-counter, you must read the instructions for use, let us consider the most important provisions of this document.

Pharmacological essay

Since we are talking about an over-the-counter drug that can be used for self-medication, before giving it to a child, you must carefully read the instructions for using Lazolvan syrup for children.

Composition of the drug

The syrup is presented in the form of a colorless solution that does not contain impurities. The medicine is based on the current active ingredient – ​​ambroxol hydrochloride. The drug also contains the following auxiliary components:

• preservative (E210);
• flavorings;
• hydroxyethylcellulose from genetically modified cotton;
• molasses and glycerin.

5 ml of syrup contains:

• 1.23 g of sorbitol, which corresponds to 1.23 g of carbohydrates;
• ambroxol hydrochloride - 15 mg.

Indications for use:

• acute respiratory diseases with impaired mucus secretion;
• chronic bronchitis in the acute stage;
• asthmatic bronchitis;
• bronchial asthma;
• bronchiectasis of the lungs.

How does the syrup work?

Ambroxol hydrochloride stimulates the secretion of the respiratory tract. This promotes the production of a film of surface substance and increased ciliary activity. These processes facilitate the flow of mucus secretions, improving expectoration and reducing coughing. Simply put, Lazolvan is a sputum thinner with an expectorant effect.

How to take the medicine:

• Children can take syrup regardless of food consumption. For ease of dosage, a measuring cup with a volume of 2.5-5 ml is attached to the packaging of the medicine.
• During the day, children are recommended to take no more than 1.2-1.6 ml of the active substance per kilogram of weight orally.
• Children under 2 years of age can only be prescribed syrup by a pediatrician at a maximum dosage of 2.5 ml twice a day.
• The recommended dose of syrup for children 2-5 years old is up to 5 ml in the morning and evening.
• At the age of 6-11 years, you can take up to 10 ml twice a day.

Special Dosage Instructions:

• In case of severe kidney or liver dysfunction, the maintenance dose of the drug is reduced by 50%. In such pathologies, the drug can be used exclusively under medical supervision.
• To enhance the secretolytic effect of the medicine, children should drink more.

Contraindications:

Hemorrhoids kill the patient in 79% of cases

• hypersensitivity to any of the components of the drug;
• for symptoms of chronic diseases, the syrup should be prescribed by a doctor;
• For people with fructose intolerance, syrup is contraindicated due to the sorbitol content;

It is necessary to avoid simultaneous use of antitussives due to the risk of inflammatory processes.

Side effects

To assess the frequency of side effects, experts use the following gradation:

• general - less than 10%, but more than or equal to 1%;
• from time to time or occasionally - less than 1%, but more than or about 0.1%;
• rarely - less than 0.1%;
• For side effects that were not observed during clinical trials, but appeared spontaneously in post-marketing studies, the concept is little known.

Immune response:

• in rare cases, the appearance of a rash or hives;
• little known - anaphylaxis, edema of angioedema, hypersensitive reactions.

Stomach disorders:

• general - the appearance of nausea, temporary loss of sensitivity of the mouth and larynx;
• occasionally - vomiting, diarrhea, abdominal pain, dry mouth;
• little known - drying out of the throat mucosa.

Psychosomatic reactions:

general - changes in taste sensations.

General instructions

The drug should be used before the expiration date indicated on the bottle. The syrup is stored at a temperature of 15 to 25°C out of the reach of children. After administration, the active substance is absorbed quickly and almost completely excreted through the kidneys. Food consumption does not change its bioavailability.

Composition and properties of syrup

Lazolvan is a drug that has expectorant properties.

The active component of the cough medicine is ambroxol hydrochloride. Other auxiliary components: glycerol, benzoic acid, flavoring, sorbitol, etc.

The therapeutic effect of the drug is achieved thanks to the active component - ambroxol. Lazolvan has a secretomotor and secretolytic effect on the respiratory tract, which allows increasing synthesis and stimulating secretion. As a result, the secretion of mucous secretion increases and is removed outside.

The action of the drug is based on the activation of hydrolyzing enzymes in the cells of the bronchial glands, which helps reduce the viscosity of sputum.

The active substance, when ingested, dilutes, strengthens and removes mucus from the bronchi. The drug Lazolvan has an expectorant and mucolytic effect. The process of secretion of sputum in the bronchi increases and the movement of epithelial cilia in the respiratory tract is activated, which help remove it from the bronchi.

The mucolytic is used to treat only productive cough. After taking the drug, the severity of cough decreases and the patient’s condition improves. The active substance is well absorbed from the gastrointestinal tract and has a high absorption capacity. Concentration in the blood is observed a couple of hours after the child has taken the syrup orally. The effect of the drug is observed after 30 minutes. Metabolism occurs in the liver, and the drug is excreted by the kidneys.

Release form, shelf life and storage

The syrup has a viscous consistency and a pleasant berry aroma, which is convenient to give to children. Sold in pharmacies in the form of syrup with different concentrations of the active substance - 15 mg and 30 mg. The syrup in a dark bottle can be produced in volumes of 100 ml and 200 ml. In 5 ml of syrup the content of the active substance ambroxol is 15 mg.

There are also other dosage forms in the form of tablets, drops and inhalation solution. It is very convenient to give to children in the form of syrup and inhalation. The drug can be stored for 3 years. The medicine must be placed out of the reach of children. The optimal temperature for storage is no more than 25 degrees. Once opened, close tightly and store in a cool place.

Application of Lazolvan

Lazolvan syrup for children can be taken in the following cases, as indicated by the instructions for use:

• with pneumonia;
• for lung infections that accompany obstructive syndrome;
• with bronchiectasis;
• for acute and chronic bronchitis;
• for bronchial asthma;
• for COPD;
• for distress syndromes in premature infants, accompanied by cough and impaired pulmonary function.

It is worth remembering that this medicine is prescribed by a doctor. You cannot prescribe its use on your own.

Cough syrup Lazolvan differs from other remedies in that it acts in the shortest possible time. Thanks to this, there is a rapid improvement in the condition and pain symptoms are relieved.

The instructions for use state that Lazolvan for children also includes:

• sorbitol;
• benzoic acid;
• potassium acesulfate;
• hyaetellosis;
• glycerol;
• flavorings;
• purified water.

Lazolvan for children is available in bottles of 100 and 200 mg. They are made of opaque glass. The box also contains a measuring cup and instructions for use.

Lazolvan syrup for children has a transparent appearance. Depending on the added flavorings, its taste may be different. Most often it is strawberry or raspberry. Children usually take Lazolvan for children with pleasure due to its pleasant taste.

Procedure

Let's consider the basic rules for inhalations with Lazolvan:

1. Prepare an inhaler, preferably a nebulizer.
2. Do not carry out the procedure if the thermometer shows more than 37.5 degrees - wait until the temperature returns to normal.
3. Inhale and exhale calmly, freely and rhythmically. Posture or clothing should not restrict breathing.

Is it possible to do inhalations without a nebulizer?

A nebulizer is needed to turn liquid into an aerosol without heating. Due to this, even the tiniest droplets of the drug reach hard-to-reach areas of the mucosa. The instructions for using Lazolvan indicate that it is optimal to use a nebulizer for inhalation, but if you don’t have one, other inhalers are also suitable. The main thing is not to use devices that heat steam. This article will tell you about choosing the right nebulizer.

Indications for the medication

The active component of Lazolvan is Ambroxol. The product helps thin mucus, improves the removal of mucus from the respiratory tract, and relieves spasms and swelling in the lungs.

The instructions for the medicine indicate that it is allowed for the treatment of children from the first days of life. Several forms of medication are used in therapy. Depending on the age of the baby, the optimal method of treatment is selected.

Self-medication of children is prohibited! Consultation with a pediatrician is required. During the treatment process, it is recommended to follow the doctor’s instructions and strictly adhere to the dosage to avoid negative consequences.

The drug is prescribed if the child has been diagnosed with:

• Pneumonia;
• Bronchial asthma;
• Tracheitis;
• Chronic or acute bronchitis;
• Cystic fibrosis;
• Bacterial or viral infection of the lower respiratory tract, cough with sputum.

Lazolvan is effective in combating various diseases of the lungs and respiratory tract, which are accompanied by a strong cough and poor mucus production due to the increased viscosity of mucus.

Contraindications

Lazolvan tablets are not recommended for women in the 1st trimester of pregnancy, as well as during breastfeeding. During the 2nd and 3rd semesters of pregnancy, the drug is prescribed only when necessary and after the doctor’s permission. "Lazolvan" is contraindicated for children and adolescents up to adulthood. A special form has been released for them in the form of baby syrup. Avoid the substance at the first sign of intolerance or kidney or liver problems. In case of acute bullous lesions of the mucous membranes and skin (a pronounced inflamed allergic rash), the temperature may rise, painful sensations in the body may occur, the cough may intensify, and the nasopharyngeal mucosa may become inflamed. Side effects include nausea, dizziness, vomiting, loose stools, gastrointestinal disturbances, allergic skin rashes, itching, and rarely, shock reactions, anaphylaxis. No overdoses of the drug have been observed, but in case of unpleasant symptoms it is necessary to perform gastric lavage, induce vomiting, and drink activated charcoal.

It is not recommended to combine the medicine with other antitussive drugs.

Analogues:

• "Bronchorus";
• "Ambrobene";
• "Medox";
• "Halisol";
• "Ambrosol";
• "Ambro-Hexal";
• "Ambroxol-Verte";
• "Deflegmin."

The shelf life of Lazolvan in tablets is no more than 5 years. It is better to store in a dark, cool place at a temperature no higher than 30 degrees Celsius, away from children.

How to take Lazolvan syrup

Lazolvan syrup is taken according to the regimen recommended in the instructions (according to the patient’s age), without taking into account meals, washing down the drug with water. For patients with serious liver and kidney diseases who have been prescribed Lazolvan, it is recommended to start using a reduced dose, or you can increase the break time between doses of the medicine. If a person forgets to take the medicine, the intake continues according to the previously determined dosage regimen.

Lazolvan – dosage

Lazolvan 15 mg – age, dose and number of doses per day:

• 12 years and adults – 10 ml, 3 times;
• 6-12 years – 5 ml, 2-3 times;
• 2-6 years – 2.5 ml, 3 times;
• up to 2 years – 2.5 ml, 2 times.

Lazolvan 30 mg – age, dose and number of doses per day:

• 12 years and adults – 5 ml, 3 times;
• 6-12 years – 2.5 ml, 2-3 times.

How to give Lazolvan syrup to children?

Lazolvan - syrup for children - an effective remedy for colds, pneumonia, bronchial asthma and other diseases that cause coughing

The drug is safe for children, but it is important to follow the dosage and not allow the child to take additional sweet medicine. For children under 6 years of age, the drug must be prescribed by a doctor.

In the first days of treatment, the child may begin to cough more often - this is a normal process; gradually the cough will soften and disappear.

How to take Lazolvan syrup for children:

1. An adult should carefully measure the required volume of medication using a measuring cup.
2. After making sure that the time to take the medicine has come, give the drug to the child.
3. So that the child can drink the drug, give him a glass of clean water.

How long can you take Lazolvan syrup?

You should take Lazolvan for as long as prescribed by your doctor. If there has been no consultation with a pediatrician, Lazolvan (use for children over 6 years of age is allowed without a doctor’s prescription) is taken for 5 days. If the patient's condition improves, you can switch to taking Lazolvan twice a day - once every 12 hours. If the patient’s condition does not improve within this period, you should consult a doctor. If the patient's condition worsens or side effects occur, you should immediately consult a doctor.

special instructions

Before you start using the drug, read the special instructions:

1. The sorbitol contained in the syrup may have a mild laxative effect.
2. If kidney function is impaired, Lazolvan should be taken only as prescribed by a doctor.
3. Lazolvan syrup should not be used in combination with antitussives that impede the removal of sputum.
4. Isolated cases of severe skin lesions have been reported, for example, Stevens-Johnson syndrome and Lyell's syndrome, which coincided with the administration of ambroxol; however, the relationship with the drug has not been proven. If the above syndromes develop, it is recommended to stop treatment and immediately seek medical help.
5. Lazolvan syrup (30 mg/5 ml) contains 5 g of sorbitol in terms of the maximum recommended daily dose (20 ml), Lazolvan syrup (15 mg/5 ml) - 10.5 g of sorbitol in terms of the maximum recommended daily dose (30 ml). Patients with rare hereditary fructose intolerance should not take this drug.

There were no cases of the drug affecting the ability to drive vehicles and machinery. Studies on the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions have not been conducted.

Pharmacological properties

Pharmacodynamics

Research data show that ambroxol, which is the active component of Lazolvan, causes an increase in secretion in the respiratory tract. As a result of exposure to the drug, the production of pulmonary surfactant and ciliary activity are enhanced. These effects stimulate the flow and transport of mucus (mucociliary clearance), resulting in intense mucus discharge and cough relief. In the treatment of chronic obstructive pulmonary disease during long-term therapy with Lazolvan (for 2 months or more), the number of exacerbations decreased significantly. A significant decrease in the duration of exacerbations and the number of days of antibiotic therapy was recorded.

Pharmacokinetics

All dosage forms of immediate release ambroxol are characterized by rapid and almost complete absorption (a linear dependence of absorption on dose is observed). When taken orally, the maximum concentration of ambroxol in plasma is achieved after 60–150 minutes. Distribution volume – 552 l. The binding of ambroxol to plasma proteins in the therapeutic concentration range is approximately 90%.

When administered orally, the transition of the active substance from the blood to the tissues occurs quickly. The highest concentrations of ambroxol are observed in the lungs. About 30% of an oral dose undergoes a first pass process through the liver. Studies on human liver microsomes have proven that the predominant isoform is the CYP3A4 isoenzyme. It is responsible for the metabolism of the active substance to dibromanthranilic acid. The remaining amount is metabolized in the liver, mostly by glucuronidation and through partial degradation (approximately 10%) to dibromoantranilic acid and additional metabolites in small quantities. The terminal half-life is 10 hours. Total clearance is up to 660 ml/min, with about 8% of the total clearance being renal clearance. In studies using the radioactive tracer method, it was calculated that as a result of taking a single dose of ambroxol over the next 5 days, approximately 83% of the dose taken is excreted in the urine.

A clinically significant effect of gender and age on the pharmacokinetics of ambroxol has not been recorded, so there is no reason to select the dosage based on these characteristics.

Effect of Lazolvan on dry cough

What cough does Lazolvan help with?
The drug can be used for both dry and wet cough. Dry cough is most common when:

• tracheitis (inflammation of the trachea);
• laryngitis (inflammation of the larynx).

To determine the presence of a dry or wet cough, the doctor listens to the sick person's lungs with a stethoscope. If the patient hears whistling sounds during inhalation or exhalation, this indicates the presence of inflammation and the formation of thick mucus. In this situation, the cough does not bring relief to the patient, since the sputum cannot be separated and removed from the body. With this phenomenon, the best solution in this situation would be to take the drug Lazolvan.

Irritation of the mucous membrane of the larynx can cause a dry cough. In this situation, there is no wheezing in the lungs. In this circumstance, Lazolvan can only worsen the patient’s health, since taking the medicine can provoke another spasm. A dry cough will only get stronger and more severe.

Directions for use and dosage

The dosage regimen of the drug depends on its release form and the age of the patient. The syrup is drunk, the inhalation solution is poured into a children's nebulizer, the atomized liquid is inhaled, the tablets are indicated for use by adults over 18 years of age. The course of taking the drug Lazolvan depends on the severity of the symptoms of lung diseases and the doctor’s instructions. The lozenges are dissolved in the mouth, for children over six years old - one piece 2-3 times a day, after 12 years - two pieces two or three times.

Lazolvan syrup

The drug at a concentration of 3 mg/ml is prescribed to adults in the first 2-3 days, 10 ml, in the following days the dosage is reduced to 5 ml three times or 10 ml twice a day. In severe cases of bronchial diseases, the dose is not reduced throughout the entire course of therapy. Children 5-12 years old are recommended to take 15 mg 2-3 times a day, 2-5 years old - 7.5 mg three times, up to two years old - 7.5 mg twice. Lazolvan is not prescribed for children under one year of age; the approximate course of treatment for respiratory diseases is 4-5 days.

Pills

Only patients over 18 years of age can be prescribed tablets. Take them orally at 30 mg (1 piece) three times a day. To enhance the effect of treatment, in agreement with doctors, 60 mg (2 pieces) are prescribed twice a day. Taking the medicine in tablet form is accompanied by liquid, milk; the time of use is not related to food intake. Use the tablets for about 4-5 days.

Lazolvan for inhalation

As an additional treatment for cough, Lazolvan is used for inhalation in children. The solution is poured into the nebulizer according to the instructions, and particles of the suspended liquid are inhaled. One or two procedures lasting 5-10 minutes are allowed per day. Up to two years, the prescribed dosage is 7.5 mg, 2-5 years - 15 mg, over five - 15-22.5 mg. If it is not possible to carry out more than one procedure daily, therapy is intensified with syrup or oral solution.

Drops

Oral solution or drops are prescribed by a pediatrician at a concentration of 7.5 mg/ml. Consumption is not related to meal times; the solution can be used for inhalation. Dosage depends on age:

• adults: 4 ml daily in the first 2-3 days, then 2 ml three times a day or 4 ml twice;
• children under two years old - 1 ml twice a day;
• 2-5 years – 1 ml three times a day;
• 5-12 years – 2 ml 2-3 times a day.

Lazolvan injection solution

In severe cases, in hospital conditions, the drug can be administered parenterally (intravenously). The daily dose is 30 mg per kilogram of body weight, divided into four procedures per day. The solution is injected slowly, over at least five minutes. If you mix Lazolvan with a glucose solution, physiological or Ringer's, it is allowed to administer it intravenously.

When should you take the drug?

The attached instructions contain important information about dosages - in what quantities and for how long to give Lazolvan to a 3-year-old child. The drug is prescribed to infants for various pathologies caused by inflammatory or infectious processes.

Syrup

The syrup is often used to treat infants. It has a pleasant, sweetish taste, thanks to which the child drinks it with pleasure.

There are several forms of release of the product:

• 5-tl ml/30 mg ambroxol (taken by children under six years of age);
• 5 ml/15 mg ambroxol (recommended for newborns up to one year of age).

The attached instructions contain important information about safe dosage, taking into account the child’s age and other characteristics. Adults are advised to read this information.

For infants, Lazolvan fruit syrup can be diluted with a small amount of milk or boiled water. The product has a better effect on the child’s body if he drinks a lot of water during the treatment process.

Inhalations

The solution for inhalation will relieve the baby of a dry cough in the shortest possible time. For inhalation, the dosage of Lazolvan for a 3-year-old child is prescribed exclusively by the attending physician, taking into account the nature of the pathology that has arisen.

Recommended dosages:

• Dose 1 ml / up to 2 years;
• Dosage 2 ml / up to 5 years;
• Dose 4 ml / age from 5 years.

It is also recommended to use Lazolvan drops in parallel for children aged 3 years, which help eliminate swelling of the mucous membrane. The product, like the syrup, is contained in special containers that have dark glass. The concentration of the active substance is 15 mg / to 2 ml.

Lazolvan for inhalation for a 3-year-old child is added to a special inhaler before use. The procedure takes no more than 7 minutes.

Pills

Lazolvan tablets are prescribed to patients over the age of twelve. The tablet contains 30 mg of ambroxol. To treat infants, of course, it is better to use syrup.

Lazolvan tablets are contraindicated for a child aged 3 years, since the limit per dose exceeds the permissible level. Only in an emergency, you can divide the tablet in half, crush 1/2 of it, dilute it with water and give it to your baby.

Injection

In this case, Lazolvan is introduced into the child’s body by injection.

Recommended dosages:

• for a child under 1 year of age – 1 ml once a day;
• children under 2 years old – 1 ml several times a day;
• up to 5 years of age - three times a day, 1 ml per day;
• up to 12 years – 2 ml three times a day.

Injection solutions are recommended to be combined with inhalations to achieve a more effective treatment result.

Sources:

Vidal: https://www.vidal.ru/drugs/lasolvan__433 GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=059eef4d-4dac-49a0-b5c3-a5c9a15182a8&t=

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Pharmacological group

Lazolvan belongs to the group of drugs with mucolytic and expectorant effects (mucolytics).

Pharmacodynamics

The active ingredient ambroxol hydrochloride increases the secretion of mucus in the bronchi of various sizes, thins the mucus, stimulates the activity of the cilia of the respiratory tract mucosa, and promotes the synthesis of pulmonary surfactant (a substance that normalizes the functioning of the pulmonary alveoli). As a result, mucociliary clearance is activated - the transport of mucus in the respiratory tract. Mucolytic action helps to liquefy viscous sputum. The expectorant effect leads to the removal of excessive amounts of inflammatory exudate (mucus) from the bronchi through cough impulses.

Lazolvan is used for dry coughs to improve sputum separation and for wet coughs to effectively cleanse the respiratory tract of mucus. Ambroxol hydrochloride improves the penetration of antibiotics into the bronchi and lung tissue, which increases the effectiveness of antibacterial therapy and reduces the duration of drug use.

Pharmacokinetics

When administered orally, Lazolvan is quickly absorbed from the digestive tract. The maximum concentration of the drug in the blood plasma is achieved after 60-90 minutes. Ambroxol hydrochloride accumulates in the lung tissue and bronchial mucosa, which determines the therapeutic effect of the drug. The distribution of the substance between plasma and cells occurs quite quickly. Lazolvan was found in insignificant concentrations in other tissues of the body during clinical trials. 90% of the drug binds to transport proteins in the peripheral blood. Lazolvan is metabolized in liver cells. More than 95% of the drug is excreted from the body by the kidneys. The half-life from the body is 8-12 hours. Ambroxol hydrochloride is not characterized by long-term accumulation in tissues.

Composition and properties of the drug

The medicine is part of the pharmacological group of mucolytic drugs, that is, sputum thinners. Children's syrup "Lazolvan" is produced in the form of an almost transparent liquid, moderately viscous, with a fruity aroma. The main active ingredient of the drug is ambroxol hydrochloride, which stimulates ciliary activity and the formation of pulmonary surfactant. In other words, it activates the production of mucus in the respiratory tract, facilitates its separation and reduces coughing. Ambroxol is absorbed into the blood quickly enough, so the therapeutic effect is noticeable after a short period of time. In the interval from half an hour to three hours after using the drug, the concentration of the active component in the blood reaches its maximum. A significant amount of ambroxol is concentrated in the area of ​​influence of the drug - in the lungs. The main advantage of the drug is that it is quickly eliminated from the body and does not accumulate in tissues.

Side effects from taking the medicine

When reading the instructions for use for Lazolvan children's syrup, important attention should be paid to the presence of side effects from taking this drug. According to pharmacists, this medicine most often does not have them completely, but sometimes you can observe side effects of the drug, signaling the need to stop treatment. Thus, among the side effects of treatment there are sudden weakness, nausea, vomiting, diarrhea, various allergic reactions, rashes all over the body, dry throat or mouth, itching, hypersensitivity and even anaphylactic shock.

Having noticed such an inadequate reaction of the body to taking the syrup, you should immediately stop taking it and consult a doctor who will prescribe another cough medicine and symptomatically treat the side effects if they do not go away on their own after stopping the use of this medicine

Thus, among the side effects of treatment there are sudden weakness, nausea, vomiting, diarrhea, various allergic reactions, rashes all over the body, dry throat or mouth, itching, hypersensitivity and even anaphylactic shock. Having noticed such an inadequate reaction of the body to taking the syrup, you should immediately stop taking it and consult a doctor, who will prescribe another cough medicine and symptomatically treat the side effects if they do not go away on their own after stopping the use of this medicine.

Analogs

Any other medicine containing the same active compound can replace Lazolvan syrup. The range of such products is quite large and includes the following drugs:

This medication is produced by the Sandoz company in liquid form (solution, syrup) and solid form (tablets and capsules).

This medication is produced in Germany in tablet form and in solution.

The medicine from the Russian manufacturer is presented in syrup, tablet form and solution.

This domestic drug is produced in the form of syrup and tablets.

Ambrobene

The drug from Germany is produced not only in syrup, but also in the form of an oral solution, tablets, capsules and ampoules for intravenous injection.

This Czech medicine is produced in syrup and tablets.

This drug from Serbia is produced in the form of effervescent tablets and syrup.

Ambrolor

This is Russian-made syrup.

In addition, the doctor may prescribe cough medications with a different composition. This could be ACC, Bromhexine, Prospan, Gedelix, or another drug with a similar therapeutic effect on the bronchi.

Inhalations with lazolvan are an effective cough remedy. How to give inhalation to a child? You can see this in more detail in the video lesson.

Instructions for use

The medicine is intended for oral use (by mouth). The absorption of ambroxol does not depend on the presence of food in the stomach. Before starting treatment, be sure to carefully read the detailed instructions for using the syrup.

Indications for use

Lazolvan children's syrup has a positive result for wet cough with severe expectoration of sputum, which accompanies the following diseases:

• bronchitis of all types (acute and chronic);
• pneumonia (inflammation of lung tissue);
• chronic obstructive pulmonary disease;
• bronchial asthma (with sticky sputum);
• bronchiectasis.

Contraindications

For a number of conditions the medication is not recommended for use:

• the presence of allergic reactions to ambroxol or auxiliary components included in the syrup;
• patients with fructose intolerance (this is a fairly rare hereditary disease).

Since the product is also used by adults, contraindications also include:

• first months of pregnancy;
• lactation.

Caution should be exercised in case of renal and hepatic insufficiency (dosage adjustment is often required)

Side effects

There were no significant negative effects on the body. But there is evidence of possible negative phenomena:

• From the digestive tract: feeling of nausea, diarrhea, vomiting, dry mouth, partial numbness of the oral cavity, dyspeptic disorders (impairment and pain during digestion).
• Allergic reactions - mainly the appearance of a rash, urticaria, sometimes severe anaphylactic conditions (Quincke's edema) develop.
• Quite rarely, a disorder of the sense of taste (dysgeusia) is observed.

Overdose

Possible in case of violation of dosage or mistaken simultaneous intake of a large amount of syrup (by children). However, no characteristic symptoms were noted. Only increased side effects were observed.

• To eliminate symptoms, perform gastric lavage (induce vomiting) immediately after administration or within two to three hours.
• If necessary, take medications to relieve overdose symptoms.
• It is best to call an ambulance and go to the hospital.

In what cases is it used?

The drug Lazolvan (solution) is recommended for oral administration in acute or chronic diseases of the respiratory system, characterized by the production of viscous sputum:

• bronchiectasis;
• asthma with weak sputum production;
• COPD;
• pneumonia;
• bronchitis in acute or chronic form.

Due to the activation of pulmonary secretion clearance and improved sputum evacuation, coughing is also relieved. With long-term treatment of COPD (at least 8 weeks in a row), it is possible to significantly reduce the frequency of exacerbations of the disease.

Is it possible to use Lazolvan solution to treat children? Instructions for use for children from the first year of life recommend using the medication in small doses.

Which is better Lazolvan or Erespal

Lazolvan and Erespal are analogues, but they have different components. The active substance of Erespal is fenspiride hydrochloride. It has a complex effect on the body. It exhibits not only an anti-inflammatory effect, but also an antispasmodic and antiallergic effect. Once ingested, swelling, redness and inflammation are quickly relieved. The effect of ambroxol is slightly different. It reduces the viscosity of secretions and regulates the balance between mucous and serous components. In addition to all this, when taking Lazolvan, the work of enzymes is activated, which improves the production of pulmonary lubrication and the process of self-cleaning of the respiratory organs. Erespal costs a little more, but has a long list of indications. It is prescribed to patients with bronchial asthma, bronchitis, whooping cough, measles, allergic reactions. Allowed only for children over two years of age. It’s difficult to say which is better, because it all depends on the type of disease, the age of the patient and the presence of complications.

During pregnancy and lactation

Ambroxol can cross the placental barrier. Preclinical studies did not establish any direct or indirect negative effects of the drug on pregnancy or labor. Based on clinical experience with the use of the drug from the 28th week of pregnancy, it was found that there is no negative effect on the fetus, but during this period it is important to adhere to precautionary rules.

It is preferable not to use Lazolvan in the first trimester of pregnancy. Use in the second or third trimesters is permitted only when the likely risk to the baby is less than the potential benefit to the woman. Ambroxol is excreted in breast milk. There is no information about the occurrence of undesirable effects in breastfed children. But it is advisable not to use Lazolvan during lactation.

Release forms of Lazolvan for adults

An adult can consume from 90 to 120 mg of the drug per day. Usually three doses of the drug are prescribed per day.

Syrup

A tasty substance containing 15 mg of active substance in 5 ml of the drug is prescribed to children over 12 years of age and adults 10 ml three times a day.

A syrup containing 30 mg of active substance in 5 ml of the drug is prescribed to children over 12 years of age and adults, 5 ml three times a day. A drug with a concentration of 30 ml of active substance per 5 mg of the drug is not prescribed to children under 6 years of age.

Pills

They are usually prescribed to adults and children over 12 years of age, 1 tablet three times a day for the first 2 days. On the third day, the medicine is taken 2 times a day until the symptoms become less severe.

Then you can reduce the dose to 0.5 tablets, which you drink 3 times a day. It is recommended to drink the medicine until the cough completely disappears.

Lazolvan Rino

Lazolvan rino spray is used to relieve nasal congestion during:

• colds (acute respiratory infections, acute respiratory viral infections);
• sinusitis;
• allergic rhinitis, seasonal allergic rhinoconjunctivitis.

Lazolvan Rino aerosol constricts the vessels located in the nasal mucosa, which helps relieve swelling of its tissues and congestion.

Instructions for use of Lazolvan Rino

Lazolvan rino spray can be used by adults and children over 12 years of age 4 times a day for no more than 7 days.

The injection is carried out in each nasal passage, after cleaning the nose.

Lazolvan rino is not recommended for use in children under 6 years of age.

Lazolvan rino is not recommended for the following diseases:

• atrophic rhinitis;
• angle-closure glaucoma;
• intolerance to the components of the spray.

You cannot use Lazolvan Rino spray in the first trimester of pregnancy.

People who have undergone nasal surgery should not use Lazolvan Rino spray. You can easily find other fairly effective analogues that even cost less.

Lazolvan lozenges

1 lozenge contains 15 mg of active ingredient.

The lozenge is slowly dissolved in the mouth. It is permissible to dissolve 2 lozenges 3 times a day. The drug is taken between meals.

Solution for oral administration and inhalation

The solution is used not only for inhalation, but it is also prescribed for oral administration.

Note: 1 ml solution = 25 drops

The solution is taken regardless of diet. It can be added to water, tea, juice and even milk.

Children over 12 years of age and adults take 4 ml of solution three times a day.

Lazolvan for injection

The injection is performed intravenously or in the form of a dropper. The dosage should not exceed 30 mg/kg body weight. The drug is administered 4 times a day. The injection is done very slowly, the duration of drug administration should be at least 5 minutes.

You can administer the drug using a dropper.

Recommendations for use

The drug is recommended for the treatment

• inflammatory processes in the respiratory system;
• infectious diseases of the respiratory tract.

It is used to treat pneumonia and bronchitis, to alleviate obstructive bronchitis and bronchial asthma.

Premature babies are often born with an underdeveloped respiratory system, called respiratory distress syndrome. Due to the property of the active substance to activate the production of surfactant (a liquid that protects lung tissue) in the lungs, it is effectively used to treat premature babies.

Forms of the drug

In regular pharmacies they sell:

1. solution in a dark glass bottle with a volume of 100 ml;
2. ampoules for injection (15 mg/2 ml, 2 ml ampoules, 10 pieces per package);
3. tablets (1 tablet contains 30 mg of ambroxol; packaged in blisters of 10 pieces);
4. syrup (concentration of 15 and 30 mg of ambroxol in 5 mg of the drug)
5. Lazolvan solution for oral administration and inhalation
6. nasal spray - lazolvan rino.

Lazolvan for children is presented in the form of a colorless syrup with a pleasant fruity taste (raspberry, citrus or apricot). Also a children's drug - lazolvan solution for inhalation.

Active substance

The main active ingredient of lazolvan is ambroxol, which has good penetrating ability. The effect of the medicine begins 20-30 minutes after it enters the human body and lasts for 8-12 hours.

The active substance is well excreted by the body and does not accumulate in it.

Effect of the drug

For dry cough and difficulty clearing the throat, the medicine helps to thin the mucus and remove it.

Improves the penetration ability of antibiotics accompanying treatment, such as erythromycin, gentamicin, amoxicillin, while promoting the effect of drugs on the site of inflammation. What is the price of the drugs and the price depends on the form of release of the drug?

Price depending on shape

The price of the solution for inhalation is 360-440 rubles.

The price of tablets is from 260 rubles (30 mg x20).

The price of lazolvan in lozenges is from 240 rubles (15 mg No. 20). You can also find it for 170.

Syrup price: concentration 15 mg - from 250 rubles, 30 mg - from 280 rubles.

The price of a nasal spray is 260-300 rubles.

Shelf life and cost

The medicine is valid for 3 years (from the date of production). After the expiration date, it is prohibited to use the syrup. The drug must be stored in a place protected from sunlight. In addition, the room temperature should not rise above 25 degrees Celsius. Lazolvan syrup, like any medicine, should be stored in a place where children cannot reach.

To prevent Lazolvan from losing its beneficial healing properties, it should be stored in a dark place, away from sunlight.

The price of the medicine in the form of syrup is equal to 250 rubles for a volume of 100 ml.

Analogues of the drug Lazolvan and the cost of the drug

Lazolvan has more than a dozen analogues in terms of the chemical composition of the drug, but not all of them can be used to treat cough in children.
There is also a significant variation in the cost of expectorants depending on the manufacturer. For example, there are several types of the drug “Ambroxol”: “Ambroxol-Verte”, “Ambroxol-Vial”, “Ambroxol-Hemofarm” and many others. The most accessible analogues of Lazolvan are the drugs Bronchorus and Ambroxol. Medicines such as Ambrohexal, Lazolangin and Ambrobene are a little more expensive. The drug "Lazolvan" can be bought in almost every pharmacy without a doctor's prescription. The cost of the product ranges from 200 to 450 rubles, depending on the dosage, release form and type of packaging. For example, a package of 20 tablets costs from 200 to 230 rubles, and for 50 tablets you will have to pay from 400 to 450 rubles. Lazolvan syrup for children can be purchased for 210-250 rubles, and for adults - from 240 rubles per 100 ml bottle. The greatest variation in prices is observed for the Lazolvan solution: for a 100 ml bottle you can pay from 350 to 430 rubles.

When choosing the drug “Lazolvan” to eliminate cough in a child, it is important to carefully consider the form of the drug and its dosage. Remember that medicine for adults can cause serious complications when used to treat children!

When is the medicine prescribed?

The syrup is prescribed for respiratory diseases accompanied by the release of viscous sputum.

Medicinal syrup Lazolvan is used to treat acute and chronic respiratory tract diseases, accompanied by sputum production.

Such diseases are:

• Bronchitis (inflammation of the bronchi).
• Pneumonia (pneumonia).
• Chronic obstructive pulmonary disease (structural changes in blood vessels and lung tissue are observed).
• Bronchial asthma (non-infectious disease of the respiratory tract).
• Bronchiectasis (characterized by dilatation of the bronchi).
• Cystic fibrosis (a hereditary disease in which the exocrine glands are affected and severe dysfunction of the respiratory system is observed).

The drug may also be prescribed to treat respiratory distress syndrome that occurs in premature babies and newborns. If necessary, Lazolvan can be used for chronic forms of nasopharyngitis, laryngitis, laryngotracheitis.

The drug is used in the preoperative period and after surgery to carry out sanitation of the bronchial tree.

Dosage for children and application features

The drug is taken internally regardless of food intake

Before using Lazolvan, you must read the instructions. The drug is taken orally

It is important to follow the dosage rules to avoid overdose. The dose is prescribed taking into account the age of the patient

Can be taken by children from birth.

• Children under 2 years of age are given the drug in a dosage of about 2.5 ml in the morning and evening, which corresponds to 2.5 teaspoons.
• Children over 2 years old and under 6 years old should take 2.5 ml 3 times a day.
• From 6 to 12 years, the dosage is increased to 5 ml or 1 teaspoon and the dose is divided into 2-3 times.
• Teenagers and adults should take 10 ml three times a day. This corresponds to two teaspoons.

This dosage should be followed only as directed by a doctor. After 3-4 days, improvement is already observed, but if the condition does not improve, then you should consult a doctor for advice.

It should be noted that Lazolvan should not be taken with other drugs that suppress the cough reflex and contain codeine. When Lazolvan is combined with antibiotics, the effect of the latter is enhanced. Lazolvan has an effective therapeutic effect together with plant-based mucolytic agents.

Contraindications and adverse reactions

If you have kidney failure, Lazolvan should not be taken!

Cough medicine may not be used in all cases. It is forbidden to take syrup during pregnancy in the first trimester, during lactation. Lazolvan should not be used if you are intolerant to fructose, lactose, or have a lack of lactase.

In the last two trimesters of pregnancy, the drug is used with caution. People with kidney and liver failure take the drug only as prescribed by a doctor.

Lazolvan is well tolerated by children, however, if the drug is used incorrectly, adverse reactions may occur. The following undesirable reactions are possible while taking Lazolvan: nausea, vomiting, taste disturbances. The listed side effects appear quite often. Quite rarely, dry mouth, diarrhea, dry throat, and abdominal pain are observed.

Adverse reactions may occur from the skin and immune system. Urticaria, itching, skin rashes, and in some cases angioedema, hypersensitivity, and anaphylactic reactions may appear.

In case of an overdose of the drug, diarrhea, nausea or vomiting, and abdominal pain occur. It is necessary to carry out symptomatic therapy. If after taking the drug in an overdose for 1-2 hours, symptoms of an overdose are observed, then you should induce vomiting and take activated charcoal.

Forms of the drug

“Lazolvan” is produced in different dosage forms, thanks to which it will be possible to choose the most suitable drug for each person:

1. Nasal spray. It is considered a vasoconstrictor drug that is effective in the treatment of diseases of the ENT organs. The product is presented in the form of a clear, pale yellow liquid with the aroma of eucalyptus.
2. Lazolvan solution for oral administration. The instructions indicate that a drug of this form can be used for inhalation. The solution is presented in the form of a clear, colorless or slightly brownish liquid. When performing inhalations with saline solution, the dose and duration of treatment are selected individually.
3. Syrup. This is a viscous, transparent product with a strawberry aroma. Syrup is not used for inhalation. It is taken orally.
4. Pills.
5. Pastilles.

Judging by patient reviews, all forms of the drug are easy to use and effective. After just a few procedures, there will be a noticeable improvement in the condition, and after completing the course, complete recovery is observed.

Instructions for use of Lazolvan inhalation solution, dosage

For inhalation, you can use any modern equipment designed for this (except for steam inhalers). To ensure optimal hydration during inhalation, Lazolvan solution must be mixed with 0.9% sodium chloride (salt) solution in a 1:1 ratio.

Since during inhalation a deep breath can lead to the development of a cough, they must be carried out in a normal breathing rhythm.

Before the procedure, the instructions recommend warming the Lazolvan solution to body temperature. Patients with bronchial asthma are recommended to carry out inhalation after taking bronchodilator drugs, which will help avoid nonspecific irritation of the respiratory tract and their spasm.

Standard dosages of Lazolvan solution for inhalation, according to the instructions for use:

• Adults and children over 6 years old – 1-2 inhalations of 2-3 ml of solution per day;
• Children under 6 years old – 1-2 inhalations of 2 ml of solution per day.

The duration of treatment depends on the severity of the cough, but, as a rule, does not exceed 7 days.

If no improvement is observed after 3-4 days from the start of treatment, the patient should consult a doctor for a comprehensive examination to determine the nature of the cough.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Lazolvan:

• From the digestive system - nausea, stomach pain, increased salivation, changes in appetite, vomiting, diarrhea, increased gas formation in the intestines;
• Allergic reactions - rash and scratching on the skin, urticaria, in rare cases, the development of angioedema, allergic rhinitis or bronchospasm;
• With long-term use of the drug, patients experienced a change in taste sensations (dulling of taste).

Benzalkonine chloride, which is contained in the solution, when inhaled, can lead to bronchospasm in patients with high respiratory tract reactivity - this should be taken into account when carrying out the procedure.

Contraindications

It is contraindicated to prescribe Lazolvan for inhalation in the following cases:

• in case of hypersensitivity to ambroxol and auxiliary components of the solution;
• in the 1st trimester of pregnancy;
• during lactation.

Use with caution in the 2-3 trimesters of pregnancy, as well as in case of liver and kidney failure. It is strictly forbidden to combine inhalations simultaneously with antitussive therapy.

It is strictly forbidden to combine inhalations simultaneously with antitussive therapy.

The therapeutic effect of antibiotics and antibacterial drugs increases; it may be necessary to reduce their dose and duration of treatment.

Overdose

If the recommended dose is significantly exceeded, reactions similar to side effects are observed - vomiting, diarrhea, abdominal pain.

You should artificially induce vomiting and rinse the stomach for 1–2 hours after taking the drug (if taken orally). Symptomatic therapy is indicated.

How to do inhalations correctly

It is important to know how to inhale with Lazolvan. To carry out the procedure, it is necessary to use any modern equipment intended for inhalation, for example, devices that promote the spraying of drugs in the form of tiny particles

Before using the inhaler, you should assemble it correctly and study the instructions for use, care and storage.

During the procedure, you must adhere to the following recommendations

:

• During inhalation, the patient is recommended to be in a sitting position. Carrying out inhalations in a supine position is possible only with the use of mesh nebulizers.
• Inhalations should be carried out 90 minutes after meals or physical activity.
• The aerosol is inhaled through the mouth through a specially designed nozzle: this allows you to accelerate the achievement of therapeutic effects. After inhaling, it is recommended to hold your breath for a few seconds and exhale through your nose.
• During the procedure, inhaling too deeply can provoke a severe coughing attack, so you need to breathe evenly during inhalation.
• When treating bronchial asthma, inhalation should be carried out after using medications with bronchodilator action. This helps prevent spasm and irritation of the airways.
• The recommended temperature of the finished mixture should be approximately equal to human body temperature. This helps prevent the development of irritation in the respiratory tract.
• Children wear a special mask during inhalation; adults use a mouthpiece that prevents the accumulation of medicine in the nasal cavity. The mask must first be wiped with hydrogen peroxide or a special disinfectant. You can't boil it.
• The procedure should not be performed before bedtime, since the drug stimulates the secretion and removal of mucus, which can cause a severe cough.
• You cannot use steam inhalers when performing inhalations with Lazolvan solution.

Patients with pulmonary hemorrhage, arrhythmia and severe dysfunction of the cardiovascular system should refrain from inhalation.

For what cough?

Lazolvan for dry cough reduces and softens attacks, cleansing the bronchi. With a wet cough, it promotes the production of secretions in the lungs, enhances the removal of sputum, which softens both wet and dry coughs.

A dry cough is accompanied by difficulty breathing and lack of mucus secretion. A wet cough is characterized by productive separation and removal of sputum.

The drug works as follows:

• Dilutes mucus and reduces its viscosity;
• Activates the movement of villi of the epithelial layer of the bronchi;
• Stimulates the production of sputum;
• Expands the bronchi and protects the lungs from pathologies, increasing the production of surfactant, which has protective functions;
• Improves the absorption of antibiotics amoxicillin, gentamicin, erythromycin.

Lazolvan is prescribed for diseases in children and adults:

• Permanent and acute bronchitis;
• Chronic obstructive pulmonary disease;
• Asthma;
• Inflammatory process of lung tissue;
• Bronchiectasis.

With saline solution

A pure solution is not used for inhalation. You need to know about the rules for diluting Lazolvan with saline solution. Usually the drugs are mixed in an amount of 1:1. This concentration of active substances accelerates the liquefaction and removal of sputum. The use of a solution for inhalation improves the penetration of antibacterial components into the bronchial mucus: amoxicillin, erythromycin, cefuroxime.

Inhalations must be carried out according to the following rules:

1. Up to 6 years old. Both products are mixed in 2 ml. Procedures – up to 2 times a day. The duration of the procedures is 3 minutes, and the treatment takes 4-5 days.
2. From 6 years and adults. Both products are mixed in 2-3 ml. Up to 3 procedures must be performed per day. The duration of the procedure is 5 minutes, and the entire treatment takes 4-5 days.

Inhalations cannot be performed using steam inhalers. If after a few days there is no expected therapeutic effect, a secondary consultation with a specialist is needed.

How Lazolvan syrup works

To understand how Lazolvan syrup works, you need to know that the clinical and pharmacological group to which it belongs is a mucolytic, secretolytic, secretomotor drug with an expectorant effect. Lazolvan for cough is produced in two dosages - 15 and 30 mg of the active ingredient per 1 ml of syrup. Lazolvan syrup is sold in 100 ml bottles; a measuring cup is included in the kit, allowing you to accurately measure the drug.

The main advantage of Lazolvan is that it not only thins viscous mucus, but also expands the lumen of the bronchi - this is necessary for the mucus to successfully come out. This property of Lazolvan is also very useful for premature babies whose bronchi have not fully opened. Lazolvan syrup with a low concentration of the active component is suitable for weakened and prematurely born babies, helping them to “breathe”.

Lazolvan syrup – composition

The main active ingredient of Lazolvan syrup is ambroxol hydrochloride. This is a non-toxic synthetic substance of the benzylamine group, which has a strong mucolytic effect. Lazolvan for children contains 15 mg of ambroxol per 1 ml of syrup, adult Lazolvan syrup – 30 mg. The main effect of ambroxol is to stimulate the motor activity of bronchial cilia and enhance the activity of serous cells. The action of Lazolvan begins within half an hour after administration and lasts up to 12 hours.

What does Lazolvan help with?

The initial stage of many colds is accompanied by a strong and painful cough, in which, due to the strong viscosity, there is practically no coughing up of sputum. To alleviate the condition in this case, mucolytics are prescribed. Lazolvan – for what cough is it prescribed:

• dry;
• unproductive;
• with weak sputum discharge.

To avoid dangerous situations, you should read the special instructions for Lazolvan syrup:

• the drug can cause a laxative effect due to the sorbitol included in the composition;
• for kidney diseases, the drug is taken only under the supervision of a doctor;
• Lazolvan should not be taken at the same time as medications that suppress the cough reflex;
• It is undesirable to combine Lazolvan with other mucolytic drugs - this will cause too much mucus discharge;
• the drug should not be prescribed to people with fructose intolerance;
• In extremely rare cases, severe skin lesions (Lyell, Steven-Johnson syndromes) have been reported while taking the syrup; if negative symptoms appear, you should stop taking the syrup and consult a doctor.

Pharmacokinetics and pharmacodynamics

Many parents are frightened by the cough that occurs in their child. After all, not all remedies can be used to treat a small organism. But doctors say that one of the safest remedies is Lazolvan cough syrup for children.

The drug is available in the form of a clear liquid. Has a pleasant berry taste. You can purchase the mixture in bottles of 100 and 200 milliliters. Additionally, the syrup comes with a measuring cup and instructions.

The active ingredient is ambroxol. For 5 milliliters of medicine there are 15 and 30 milligrams of the active substance. Benzoic acid, purified water, hyaetellose, glycerol, liquid sorbitol, and acesulfame potassium were added as additional components. Vanilla and creamy strawberry flavors are also present, due to which the medicine has a pleasant aroma and taste.

Contains ambroxol. It has mucolytic and expectorant properties. Its effect is aimed at the formation of enzymes, activation of the secretory function of mucosal cells and an increase in the amount of secretion. Ambroxol is absorbed quickly. Already two hours after application, the concentration reaches its maximum values. A positive effect is observed within half an hour. And the effect itself lasts up to 6-10 hours.

Some practical tips

1. Read the instructions for the drug. If it says that the medicine should not be taken with alcoholic beverages, or if it is not recommended to take it together with drugs that affect the central nervous system, alcohol cannot be combined with it. It’s just not possible, that’s all. Under no circumstances. Not in any doses.
2. Pay attention to side effects: if the annotation says that a medicine can cause conditions similar to those after drinking alcohol, then avoid taking them at the same time or for the near future.
3. Do you have any doubts - should you drink or are you scared? Don't drink. In this case, risk and champagne are mutually excluded: the likelihood is too high that an unlucky experimenter in mixing alcohol with medicine will be raised not a glass of champagne, but a funeral glass.
4. Do not ignore the warning about the hepatotoxicity of the drug, even if it comes with the disclaimer “in isolated cases.” Hepatotoxicity, that is, an active damaging effect on the liver, is one of the main characteristics of alcohol. The combination of two (and often more) drugs and alcohol that are hard on the liver can cause the rapid development of steatohepatosis or liver necrosis.

The table indicates the possibility of joint use of alcoholic beverages and the drug Lazolvan - after how long and when to take the drug

• 12 hours before drinking alcohol for women.

• 6 hours after drinking alcohol for men.

• 9 hours after drinking alcohol for women.

[!] to avoid possible health risks, give up alcohol for the entire period of treatment.

Analogues of the drug

Lazolvan for inhalation is often replaced with a similar product - Ambrobene . The drug belongs to mucolytic drugs with secretomotor, expectorant and secretolytic effects. The active component of Ambrobene is also ambroxol hydrochloride. The inhalation solution is produced in dark glass vials of 40 and 100 mg.

Inhalations with Ambrobene, as with Lazolvan, are prescribed for pneumonia, pulmonary obstruction, bronchitis, and bronchial asthma. In some cases, such treatment is prescribed to newborns.

Analogues and prices

Among foreign and Russian analogues of Lazolvan there are:

Ambrobene. Manufacturer: Ratiopharm (Germany). Price in pharmacies from 179 rubles. Ambroxol. Manufacturer: Hemofarm 83 rub. Flavamed. Manufacturer: Berlin-Chemie AG (Germany). Price in pharmacies from 190 rubles. Ambrohexal. Manufacturer: Sandoz (Switzerland). Price in pharmacies from 99 rubles. Halixol. Manufacturer: Egis (Hungary). Price in pharmacies from 121 rubles.

Composition of the drug

Lazolvan contains the active component ambroxol hydrochloride. Each form of the drug contains it in different quantities. For inhalation, use a solution of Lazolvan in saline solution. After mixing the components in the required doses, a practically colorless liquid is obtained.

Ambroxol restores breathing, eliminates swelling of the mucous membranes and inflammatory processes. After inhalation with Lazolvan, mucus comes out of the lungs, which aggravates the functioning of the respiratory organs. After the procedure, breathing tone returns to normal.

Patients who have been diagnosed with chronic obstructive pulmonary disease begin to experience noticeable relief after 45 days when implementing complex therapy.

Inhalation with Lazolvan for adults has a number of contraindications, so treatment procedures in the form of inhalation should be prescribed by a doctor.

Storage conditions

Store in a place protected from light and out of reach of children at temperatures: solution and syrup - up to 25 ºС, tablets and lozenges - up to 30 ºС.

The shelf life of the solution and tablets is 5 years, syrup and lozenges are 3 years.

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The average price of the drug Lazolvan (syrup) in Moscow is 177 rubles. Lozenges are sold for 144 rubles. In Kyiv you can buy syrup for 88 hryvnia, in Kazakhstan - for 1320 tenge. In Minsk, pharmacies offer medicine for 7-8 bel. rubles Dispensed from pharmacies with a prescription.

Over the counter.

SARU.MUCO.17.08.1246

At a temperature not exceeding 25 °C, in the original packaging.

Keep out of the reach of children.

The shelf life of Lazolvan syrup is 3 years. You should not use a medicine that has expired. The drug is stored at a temperature not exceeding 25 degrees Celsius, in a place away from direct sunlight. Lazolvan should be stored out of the reach of children with the plastic lid tightly closed until it clicks.

The cost of the medicine is 214-273 rubles.

Inhalation for children

The treatment process is the same for adults and children. Only the dosage and proportions are slightly different. Spraying of the medicinal solution is allowed for a child who has reached the age of four.

Lazolvan is prescribed to a child under six years of age in a dosage of no more than 2 ml. per day. Perform no more than two procedures per day.

Inhalation with Lazolvan for children over 6 years old is allowed to be done in a dose of 3 ml.

Parents, whose reviews can be found on specialized websites, strongly recommend inhalation for children through a nebulizer. This device converts a drug solution into an aerosol, sending it into the respiratory tract. Thanks to this device, inhalation therapies can be carried out in the comfort of your home. This is what is most often used during serious diseases of the respiratory system. Lazolvan is considered a popular and effective medicine administered to a child’s body by inhalation.

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Components for inhalation

Lazolvan is the main ingredient for inhalation with saline solution . 1 mg of the drug contains 7.5 mg of ambroxol. In addition to this substance, the medicine contains:

• citric acid in an amount of 2 mg;
• 6.22 mg sodium chloride;
• purified water;
• benzalkonium;
• hydrophosphate dihydrate.

The physiological solution contains water and sodium chloride. It is used both for inhalation and intravenous or intramuscular injection. Since the saline solution does not contain potassium salts, it has no medicinal properties in itself.

The composition for inhalation must be properly prepared. It is necessary to strictly maintain the proportions of Lazolvan and saline solution. Lazolvan should be diluted for inhalation with saline solution. The amount of both drugs should be the same.

What is Lazolvan from?

The pronounced effect makes the drug the drug of choice for a number of pathologies. Instructions for use include information about what Lazolvan tablets are used for. The list contains:

• infectious diseases of the lower respiratory tract, accompanied by the appearance of tracheobronchial secretions;
• bronchitis in various forms;
• asthma accompanied by sputum production;
• pneumonia, including viral etiology;
• cellulitis or abscess;
• obstructive diseases of a protracted type.

The drug has a complex effect. Lazolvan tablets (the instructions contain a detailed description of the mechanism):

• have a beneficial effect on the liquefaction of tracheobronchial secretions;
• accelerate the removal of sputum;
• increase surfactant synthesis.

Action of Lazolvan for wet cough

Taking Lazolvan is allowed during a wet cough or with the transformation of a non-productive spasm into a more productive one.
This often happens with acute bronchitis. Initially, the patient suffers from a constant dry cough, then after a couple of days the mucus begins to thin out. In such a situation, it is necessary to take mucolytic agents (ambroxol). If a patient has pneumonia (pneumonia), then an expectorant drug is indispensable. Lazolvan should be taken immediately after diagnosis. The patient's cough can be either dry or wet, as well as severe or mild. In some situations, seizures do not appear at all.

What effect does the drug have on the body?

Depending on the dose, ambroxol guarantees rapid and complete absorption into the blood within 2 – 2.5 hours. A large amount of the drug (approximately 30%) passes through the liver, which contains the enzyme Cytochrome P450-ZA4. Cytochrome plays an important role in the human body, oxidizing molecules of foreign chemicals (medicinal impurities) and bringing them to the surface. The remainder of the chemical drugs (10% ambroxol) remains in the liver and is broken down or metabolized by joining homologous chromosomes. The drug is completely eliminated from the body after 10 hours.

Treatment with Lazolvan is prescribed to people with diseases such as:

• Acute bronchitis;
• Bronchial asthma;
• Chronic lung disease;
• Pneumonia;
• Deformation, suppuration of the bronchi.

Before starting treatment, consult your doctor. An adult is prescribed 1 tablet of Lazolvan three times a day. The medicine is washed down with water, before or after meals. Sometimes the dose is increased. Do not self-medicate without establishing a correct diagnosis; neglect of your health can lead to adverse consequences.

Parents' opinions on children's cough syrups

In conclusion, we suggest that you read several reviews about Lazolvan syrup for children:

• Anna: “What can I say, the syrup is good, most importantly, it’s sweet. There is no need to persuade your child to drink it for a long time. I gave it to my daughter all the time, but it didn’t suit my youngest and a rash appeared. I’ll pick something else.”
• Ekaterina: “In Europe, back in 2012, they banned the use of cough syrups for children under 6-7 years old, because they are associated with more risks than benefits. First of all, you may unconsciously hide the underlying disease when you decide to treat your child without consulting a doctor.”

In practice, although cough is a very common symptom, there is no need to resort to self-medication using various medications, since it will disappear spontaneously within a few days. And when the cough lasts long and severely, it is better to consult a doctor to get a diagnosis and proper treatment, since such a symptom may be a sign of a serious illness.

Pharmacological action of Lazolvan

Lazolvan is a mucolytic agent that enhances the production of secretions in the lower respiratory tract and increases its volume. This creates the effect of quick and easy removal of mucus, which reduces the severity of the cough.

The drug has a local anesthetic (pain-relieving) effect. Lazolvan also reduces inflammation and works as an antioxidant.

When patients take the drug, the redness of the oral mucosa and throat decreases, and the severity of pain decreases.

When taken orally, the drug Lazolvan begins to act quickly, the intensity is directly proportional to the dose taken. The maximum level of the substance in the blood is reached after 1.5-2 hours, and is eliminated from the body after 6-7 hours.

Ambroxol disintegrates in the liver, 90% is excreted by the kidneys, and is not concentrated or accumulated in tissues.

Composition of the drug Lazolvan

Ambroxol is the main component of the drug Lazolvan. The medicine is available in different dosages and forms. Lazolvan can be purchased at pharmacies and is available without a prescription. Release forms and dosages:

1. Syrup.
2. Pastilles.
3. Pills.
4. Capsules.
5. Solution for inhalation.

Syrup in most cases is prescribed for the treatment of cough in children (contains fifteen or thirty milligrams of ambroxol in five milliliters).

The solution for inhalation is prescribed to children and adults (contains seven and a half milligrams of ambroxol per milliliter).

Lazolvan tablets are prescribed only to adults (available in a dosage of thirty milligrams).

Lazolvan lozenges can be used for resorption by both adults and children over six years of age (contains fifteen milligrams of the active substance).

Lazolvan capsules have a longer-lasting effect (contain seventy-five milligrams of active substance), capsules can be used by persons over eighteen years of age or older.

Contraindications and side effects

The instructions emphasize that in case of impaired renal function, use is permissible only after consultation with a doctor. According to the instructions, it is also prohibited to take it if you have a hereditary disease such as fructose intolerance, since the product contains sorbitol.

But there is no sugar or alcohol in the composition, so the drug is allowed for patients with diabetes.

Among the possible side effects, the instructions mention the following:

• from the immune system - anaphylactic shock, rashes, urticaria, dermatitis and other allergic reactions;
• taste disorder;
• from the gastrointestinal tract and respiratory system: nausea, vomiting, abdominal pain and diarrhea, dry mouth and throat.

If any side effects occur, treatment with Lazolvan should be stopped and medical help should be sought.

Interaction with other drugs

• Food intake does not affect the bioavailability of ambroxol hydrochloride.
• There is no data on clinically undesirable interactions with other drugs.
• It is known that after taking ambroxol, the concentration of antibiotics in bronchopulmonary secretions and sputum increases. This applies to substances such as amoxicillin, erythromycin and cefuroxime.
• It is strictly forbidden to take Lazolvan and cough suppressants at the same time, as this leads to the accumulation of mucus in the bronchi.

Composition of Lazolvan

The main active ingredient of the drug is ambroxol hydrochloride. It is a mucolytic that makes sputum more liquid and facilitates its evacuation from the lungs. The substance activates the movement of microscopic cilia of the epithelium and stimulates the secretion of the bronchi. Lazolvan stimulates the production of active substances that line the alveoli of the lungs from the inside. This mechanism protects the lungs from infection.

The composition of excipients depends on the form of release of the drug.

Composition of tablets:

• ambroxol 30 mg;
• lactose – carbohydrate, filler for tablets;
• corn starch is a binder used to compress tablets;
• colloidal silicon – ensures uniformity, prevents the formation of lumps, and is a sorbent;
• magnesium stearate – stabilizer and thickener.

Composition of the solution for inhalation and oral administration:

• ambroxol 15 mg;
• sodium acid salt - used in medications as an excipient;
• physiological solution – NaCl 0.9%;
• benzalkonium chloride – preservative;
• lemon acid;
• water for injection is the basis of liquid dosage forms.

Syrup composition:

• ambroxol 15 and 30 mg;
• hydroxyethylcellulose – ensures the stability and bioavailability of ambroxol;
• sorbitol is a filler that supports the structure of the drug;
• benzoic acid is a natural preservative;
• glycerin – increases viscosity, prevents the drug from drying out;
• propylene glycol is a solvent and carrier element in liquid dosage forms;
• wine acid;
• raspberry or apricot flavoring;
• purified water.

Solution for parenteral administration – Lazolvan in ampoules of 15 mg 2 ml.

Description of the dosage form

Solution for oral administration and inhalation: clear, colorless or slightly brownish.
The pharmacy chain sells syrup with varying concentrations of the active ingredient. Lazolvan with low concentration: 5 ml of syrup contains 15 mg of ambroxol hydrochloride. Lazolvani with a high concentration: 5 ml of syrup contains 30 mg of ambroxol hydrochloride. The composition of the medicinal product includes excipients to create a convenient dosage form, taste, and extend shelf life.