Bouchara Recordati Polydex nasal spray - reviews

Polydexa is an original French drug based on two antibiotics and a glucocorticosteroid. Available in two forms - ear drops and phenylephrine nasal spray. The medication is sold strictly according to prescription and is not suitable for self-medication. Since it contains antibiotics, with uncontrolled use there is a high risk of developing resistance of pathogens to the active components.

Pharmacies offer many analogues of the drug, available freely without a doctor's prescription. Before purchasing, you should study the instructions for use and consult with a specialist.

Name of the drug Polydexa Polydexa

• Active ingredient: Polydex nasal spray in 100 ml of solution contains 650 thousand units of neomycin sulfate, 1 million units of polymyxin B sulfate, 25 mg of dexamethasone sodium, 250 mg of phenylephrine hydrochloride. Polydex ear drops contain 1 ml of solution 10 mg of neomycin sulfate, 15.4 mg of polymyxin B sulfate and 1 mg of dexamethasone sodium.
• Excipients: Polydexa nasal spray contains tribasic carboxylic acid, para-hydroxybenzoic acid methyl ester, lithium chloride, lithium hydroxide, polyethylene glycol, monooleate, distilled water. Polydex ear drops include purified water, monooleate, polyethylene glycol, merthiolate, tricarboxylic acid, sodium hydroxide.
• Pharmacotherapeutic group: Polydexa refers to glucocorticosteroid drugs in various combinations.
• ATC code: according to the international system of anatomical-therapeutic-chemical classification S02CA06 Dexamethasone in combination with antimicrobial drugs.
• Release form: Polydexa is a colorless solution without a pronounced aroma in an opaque bottle. Instructions for using Polydex are attached to the medicine and placed in a branded cardboard package. Has 2 release forms:

1. spray with phenylephrine with a dispenser for irrigation of the mucous nasal passages in an individual opaque white bottle of 15 ml with a screw cap;
2. ear drops with an individual pipette for easy insertion into the ear canal, produced in bottles made of yellow opaque glass, with an individual cap.

• Storage conditions: keep the solution away from direct sunlight and children. Storage temperature: no more than 250C. The shelf life is 3 years from the date of its production. After the expiration date, the use of the drug is strictly contraindicated.
• Terms of sale: the drug is a prescription medication and is dispensed in pharmacies upon presentation of a prescription written by a doctor and executed accordingly.
• Manufacturer: Polydex with phenylephrine is produced by a pharmaceutical company whose production facilities are located in France, Levallois-Perret.

Composition, release form and principle of action of the drug

Polydexa is a complex medicine used in otolaryngological treatment. It has an antimicrobial effect against many types of microorganisms (staphylococci, Pseudomonas aeruginosa, Proteus, Klebsiella, etc. (we recommend reading: effective treatment of Klebsiella in infants).), suppresses their reproduction and leads to lysis (that is, it simply kills).

The active ingredients in Polydex are:

• dexamethasone sodium metasulfobenzoate;
• neomycin sulfate (antibacterial action);
• polymyxin B sulfate (bacteriolytic effect).

All components act on gram-negative and gram-positive bacteria. Excipients included in the composition: prepared water, thiomersal, macrogol 4000, citric acid, sodium hydroxide solution. These substances support the medicinal structure of the drug.

In pharmacy chains, the product is sold in the form of:

1. Ear drops in 10.5 ml bottles made of brown-orange glass.
2. Nasal spray with phenylephrine 15 ml. The solution comes with a special pipette attachment for easy dosing when using. The spray package also contains a spray nozzle for irrigating the nasal cavity.

Analogs of Polydex nasal spray with phenylephrine

Polydexa with phenylephrine is the only topical agent with antibacterial and vasoconstrictor properties. However, the doctor, based on the symptoms of the disease and examination data, can find a replacement for this drug:

1. Isofra (Bouchard Laboratory, France) is a topical antibacterial medicine. It contains the antibiotic framycetin, to which almost all bacterial pathogens that cause upper respiratory tract infections show sensitivity. Suitable for the treatment of bacterial acute and chronic rhinitis and sinusitis. Has a slight drying effect. Allowed for children of any age. Price 200 – 320 rubles.
2. Rinofluimucil (Zambon, Italy) is a combined agent with a sputum thinner (acetylcesteine) and a vasoconstrictor (tuaminoheptane) effect.
   Suitable for the treatment of acute and chronic rhinitis and sinusitis with viscous mucous secretions and impaired nasal breathing. In purulent inflammatory processes, the spray can only play a supporting role. Price 260 – 320 rubles.
3. Vibrocil (Novartis, Switzerland) is a combined drug with a vasoconstrictor (phenylephrine) and antihistamine (dimetindene) effect. Suitable for treating a runny nose with an allergic component. Vibrocil price 230 – 270 rub.
4. Rinostop, Rinorus 0.05% – vasoconstrictor drugs with xylometazoline. It relieves swelling of the nasopharynx well, helps restore nasal breathing and eliminate ear pain. Contraindicated for children under two years of age. Price – about 80 rubles.
5. Vibrocil nasal drops - have the same composition as the spray and are used to treat children. Price about 260 rubles.

Polydexa is a medicine with unique properties. It simultaneously has antibacterial, anti-inflammatory and vasoconstrictor (in a spray) effect. It is impossible to completely replace it. It is necessary to select a medicine that is suitable for treating a particular patient.

Patients prefer to buy cheaper medications:

Contraindications for use of the medication

The drug should not be used to treat small children under two and a half years of age. In addition, there are a certain number of contraindications. So, Polydex should not be prescribed to children in the following cases:

• Various kidney diseases and kidney failure;
• The child has glaucoma;
• Individual intolerance by the child's body to one or more components of the drug.

The medicine should not be used immediately after a child has been vaccinated against tuberculosis and polio. The effect of the drug when the baby’s immunity is weakened can provoke the development of diseases in the child, for which he was vaccinated. Polydexa is not used when treating a child with other antibiotics, which include gentamicin, amikacin and monomycin.

Since the drug has a strong vasoconstrictor effect, it should be used very carefully when:

• Hypertension;
• Coronary heart disease;
• Angina pectoris
• Various diseases of the thyroid gland.

Composition and release form

A medicine called Polydexa is a local remedy used for the treatment of ENT organs. Tablets under this name are not produced.

The official instructions classify Polydexa as belonging to several pharmaceutical groups at once, since it contains antibacterial, vasoconstrictor components and a glucocorticosteroid.

Polydexa is available for the treatment of the nose and ear, in the form of drops and nasal spray. There is no medicine for the throat with this name.

Name	Form	Package	Active components	Additional substances
Polydexa with phenylephrine	Nasal spray	Plastic bottle with dispenser, 15 milliliters, instructions.	Phenylephrine hydrochloride, dexamethasone, neomycin, polymyxin B.	Citric acid, lithium chloride and hydroxide, water, macrogol, polysorbate
Polydexa	Drops in the ear	A dark glass bottle with a pipette. 10 milliliters. Instructions.	Dexamethasone, neomycin, polymyxin B.	Thiomersal, water, macrogol, polysorbate

The medicine is registered in France. According to the instructions, it is an antibiotic, as it contains two antibacterial substances.

Polydex's analogs

The price of Polydex for the ears varies from 260 to 360 rubles, for the nose - from 360 to 480 rubles. It depends on the region, the markup of the pharmacy organization, and the availability of promotional offers from the manufacturer or supplier.

There are no analogues of Polydex with the same composition (2 antibiotics and a hormone). Substitutes differ in their included components, therapeutic effect, cost, and contraindications.

List of Polydex analogues for the treatment of diseases of the nose and ear with approximate prices and country of origin

Analogue	Price, in rubles	Manufacturer country
Polydexa ear drops	260-360	France
Polydexa with phenylephrine	360-480
Isofra	330-440	France
Sofradex	300-430	India
Rinofluimucil	260-420	Italy
Nasonex	470-920	Belgium or Russia
Otipax	320-410	France
Protargol	120-330	Russia
Derinat	200-460	Russia
Vibrocil	320-410	Switzerland
Sinupret	380-530	Germany
Dioxidine	440-780	Russia
Otofa	180-240	France
Anauran	300-420	Italy

pharmachologic effect

Polydexa is a therapeutic agent for local use that helps relieve unpleasant symptoms accompanying otolaryngological pathologies and destroy pathogenic flora that provoked the development of catarrhal processes. The pharmacological effect of the drug is determined by its composition.

This:

1. Polymyxin B – component has antibacterial and bactericidal effects. Active against gram-negative microflora, including Escherichia coli, Pseudomonas, Aerobacter, Salmonella, Shigella, Klebsiella, influenzae. The antibiotic is absorbed into cellular structures, increasing their permeability. Provokes the dissolution of pathogenic cells, reducing the severity of clinical symptoms. Resistance of infectious agents to polymyxin develops slowly.
2. Neomycin sulfate belongs to the first generation aminoglycoside group of antibiotics. It has antibacterial and bactericidal effects against gram-negative and gram-positive bacteria: Streptococcus, Staphylococcus, Salmonella, Shigella and others. When penetrating into inflamed areas, it penetrates the membrane of infectious agents, binding to receptor proteins. It disrupts the transport function of RNA of pathogens and stops their synthesis.
3. Dexmethasone is a glucocorticosteroid with antiphlogistic, antihistamine, immunosuppressive, and antishock effects. When the hormonal component penetrates the site of the disease, it interacts with cytoplasmic receptors. Stops the release of mediators of catarrhal processes from eosinophils and mast cells. Reduces the synthesis of mast cells and labrocytes.
4. Phenylephrine is an alpha-andrenomimetic, anticongestant. Has a vasoconstrictor effect. Activates adrenergic receptors. It narrows the lumen of blood vessels, causes an increase in blood pressure, reduces the volume of blood flow, reduces swelling, and relieves hyperemia.

Overdose and side effects from taking Polydex

Currently, no cases of drug overdose have been recorded. This is explained by the local effect of the medication and its weak penetration into the child’s circulatory system.

The use of Polydex, which contains phenylephrine, may cause the baby to experience discomfort in the nose, burning and tingling in the nasal passages. Rarely, some allergic reactions may occur:

• Redness of the skin;
• Quincke's edema;
• Hives;
• Itching of certain areas of the skin.

If Polydex is used for a long time, the following side effects are possible:

• Insomnia;
• Pain in the temples and occipital part of the head;
• Weakness and fatigue of the child;
• Trembling of hands and feet;
• Pale skin of the face and neck;
• Tachycardia and arrhythmia;
• Blood pressure surges.

In order to avoid the above side effects, it is necessary to accurately follow the instructions of the doctor treating the child and carefully study the instructions.

Pharmacological effect

Polydexa is a combination drug that has a local effect.

1. Dexamethasone. This component is a hormonal drug that, when applied topically, has a strong anti-inflammatory, decongestant and antiallergic effect. In complex combination with the above-mentioned antibiotics, dexamethasone gives an even stronger therapeutic result. This is expressed in the fact that inflammatory, purulent complications stop very quickly, and the patient recovers.
2. Neomycin. This component is an antibiotic that has a strong bactericidal effect. It fights infections caused by the following pathogens: Staphylococcus aureus, P. Aeruginosa, K. pneumoniae, E. coli, H. Influenzae, H. influenzae, K. Pneumoniae and Pseudomonas aeruginosa. However, streptococci, pneumococci and anaerobic bacteria are not affected by this drug. But Staphylococcus aureus, which is the main source of complications in ENT practice, ceases its negative effect on the body when exposed to neomycin.
3. Polymyxin B. The main purpose is to provide an antibacterial effect against Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae, Klebsiella pneumoniae. The combination of neomycin and polymyxin B makes it possible to expand the scope of application and fight microorganisms that provoke the development of purulent complications that occur in the paranasal sinuses, in the area of ​​the middle and outer ear. Polydex ear drops and nasal drops contain the same antibiotic content.
4. Phenylephrine. It is a vasoconstrictor used to treat rhinitis. When phenylephrine is applied topically, swelling quickly decreases, nasal congestion disappears, as does heavy discharge. This happens due to the fact that the lumen of the capillaries narrows. Now there are no questions like: is the drug Polydex with phenylephrine a vasoconstrictor or not?

Description of the drug

Polydexa is a modern antibacterial drug that is used to treat diseases of the nasal cavity and ears that have a severe course and associated complications.
Drops are used to reduce mucus secretion from the nose. The drug is complex and has anti-inflammatory, antimicrobial effects, so it is often used in ENT practice. Composition of drops:

1. Neomycin sulfate (10 mg).
2. Polymyxin sulfate (10 thousand units).
3. Phenylephrine hydrochloride (2.5 mg).
4. Metasulfobenzoate (250 mcg).
5. Dexamethasone (0.25 mg).

Neomycin is an antibiotic that has an antibacterial effect against a wide range of pathogenic microorganisms. It creates a kind of protection that prevents bacterial infections from multiplying and spreading.

Polydex should not be used for streptococcal infections. The drug is most effective against Staphylococcus aureus. To combat them, the antibiotic will need a minimum amount of time.

Another substance in the drug is phenylephrine.
It has a vasoconstrictor effect and facilitates nasal breathing. And components such as dexamethasone and polymyxin effectively destroy pathogenic microbes that cause the inflammatory process.

It should be remembered that you cannot prescribe Polydex drops yourself. If used incorrectly, this can cause serious consequences for the body.

Polydex can only be prescribed by a therapist, pediatrician or otolaryngologist. The duration of the course and dosage will depend on the person’s age, the complexity of the disease and the presence of concomitant diseases.

The drug is available in the form of a spray, which is in a polyethylene bottle that does not transmit light, with a capacity of fifteen milliliters. Additionally, a spray tip can be found in the package. Polydex packaging has a blue design.

Analogues of the drug

As analogues, you can use the following drugs as prescribed by your doctor:

1. Maxitrol.
2. Sofradex/Isofra.
3. Anauran.

Remember that only a doctor can select analogues of Polydexa by conducting cultures and determining whether the pathogenic microflora is sensitive to the components of another product. Any analogues of Polydex are also combined drugs that should be taken with caution, in accordance with the instructions and prescriptions of the doctor.

Polydexa or Maxitrol - which is better?

This drug is the most similar in composition and principle of action. Doctors agree that only Maxitrol can repeat the effect of Polydexa. Although it is used for instillation into the eyes and ears, according to the instructions, it can also be used to treat rhinitis and sinusitis.

The principle of action, side effects, spectrum of destroyed flora are very close to Polydex

The cost of this drug reaches 500 rubles.

Polydexa or Sofradex/Isofra - which drug to choose?

Preparations based on framycetin are an antibiotic that has a different spectrum of action from neomycin and polymyxin. Sofradex is applied to the nose and eyes, and Isofra is a nasal spray.

Such drugs are prescribed if the situation is not advanced and it is possible to cure the patient without resorting to the “heavy artillery” - Polydex. Also (due to their different composition) Isofra or Sofradex can be used in case of flora insensitivity to the active ingredients of Polydex.

They have fewer contraindications and side effects and can be used for children from 1 year of age.

The cost of both drugs is 300-330 rubles.

Polydexa and Anauran - what is the difference?

It is close in composition to Polydex, as it contains polymyxin, neomycin and lidocaine. We can say that this is a “simplified” version of Polydexa, which contains the most important components - antibiotics and painkillers.

The principle of action, side effects, spectrum of destroyed flora are very close to Polydex. Anauran is normally used as ear drops, but can also be used nasally.

The cost of the drug varies between 200 and 400 rubles.

Features of the drug use

Polydexa is used to eliminate inflammatory processes occurring in the baby’s nasopharynx and ears. Sometimes, after suffering a viral illness, a bacterial infection appears in the child’s weakened body, affecting the ENT organs.

Antibiotics and dexamethasone in Polydex effectively fight microbes, eliminate inflammatory processes and reduce pain.

In accordance with the instructions, the drug is used to treat children from the age of two.

Since the medicine contains an antibiotic and a hormone, it should not be used for more than 10 days. If after 5 days of using Polydex there is no improvement, its use should be stopped.

According to the instructions, the spray is sprayed into the child’s nose three times a day. Ear drops are placed in the child's ear twice a day. After using the drug, the child should lie in a horizontal position for several minutes so that the drops do not flow out of the ear.

Drug interactions

The presence of phenylephrine in the drug may adversely affect the patient's health when taking non-selective inhibitors and sympathomimetics simultaneously. It is prohibited to combine these substances with Polydexa with phenylephrine. If the recommendation is not taken into account, then the risk of developing a hypertensive crisis is likely.

It is highly undesirable to use the drug together with ergot alkaloids and selective inhibitors. Otherwise, a hypertensive crisis may develop

Caution should be used when using this product together with halogen-containing anesthetics.

The presence of dexamethasone in the drug indicates the undesirable combined use of drugs with acetylsalicylic acid. Otherwise, bleeding may occur.

Polydex with phenylephrine should be used with caution along with medications that cause tachycardia.

If the drugs used have aminoglutethimide, then a significant increase in the activity of dexamethasone is possible, so you need to reduce the Polydexa rate.

Caution is required when using this medication together with drugs that reduce potassium levels in the blood. Otherwise, hypokalemia may occur

It is undesirable to use the medicine together with digitalis preparations.

Anticonvulsants combined with Polydex with phenylephrine can lead to serious consequences for patients with Addison's disease. And taking the medicine together with Praziquantel may affect the concentration of this substance in the blood plasma.

You need to be careful when using Polydexa with phenylephrine together with:

• Erythromycin;
• antihypertensive substances;
• Clarithromycin;
• Acetylsalicylic acid;
• fluoroquinolones;
• non-steroidal anti-inflammatory drugs.

Interaction with other drugs

The use of Polydex nasal spray often occurs with combined therapy, because the instructions for use indicate that it can be perfectly combined with other medications. However, drops are still not compatible with some products:

• Bromocriptine – there is a possibility of arterial hypertension;
• Cyclopropane, Halothane - there is a risk of ventricular fibrillation;
• Guanethidine – increases the hypertensive effect of Phenylephrine;
• MAO inhibitors – possible hypertensive crisis;
• Bepridil, Sultopride, Astemizole - the use of Polydexa with these drugs has an adverse effect on cardiac activity; Combining the drug with Halofantrine, Erythromycin, and Pentamidine is also not recommended.

It is necessary to be careful during long-term treatment of the drug with Acetylsalicylic acid and antiarrhythmics.

Pharmacokinetics

Polymyxin, upon penetration into the systemic circulation, is excreted by the kidneys with urine and the gastrointestinal tract with bile within 3-4 days.

When neomycin is applied locally, systemic adsorption is minimal. After local use, it penetrates into the bloodstream only when applied to inflamed and wound surfaces. It is excreted in its original form with urine by the kidneys and with feces of the gastrointestinal tract within 2-4 hours. Can penetrate the placental barrier.

When applied topically, dexamethasone enters the bloodstream in small quantities and can therefore be found in breast milk. The placental barrier passes. When applied to wound and inflamed surfaces, absorption increases. It is excreted within 2-3 days by the kidneys and gastrointestinal tract.

When applied locally, phenylephrine is absorbed into the systemic circulation and undergoes metabolic reactions in the liver and intestines. It is excreted by the kidneys in urine.

Indications for use

In accordance with the instructions for use of Polydex ear drops, the combined medical product is prescribed to patients suffering from diseases of the ENT organs, in particular, ear pathologies. This form of the drug provides a positive effect on the treatment of a wide range of diseases. Due to the high activity of the drug due to the bactericidal properties of some components, the prescription of this drug can only be carried out by an experienced otolaryngologist after examining and diagnosing the patient.

Indications for the use of the drug "Polydex" for therapeutic purposes are the following pathological conditions:

• eczema of the external auditory canal of an infectious nature;
• otitis of the middle and external ear of an infectious or inflammatory nature (without violation of the integrity of the eardrum);
• various infectious lesions of the outer ear.

In addition, Polydex ear drops, according to the instructions, are used as a prophylactic agent and therapy for certain infectious and inflammatory complications (after surgery).

Pharmacodynamics and pharmacokinetics

Both types of drugs are used in ENT practice. They are effective against infections of the nose and ear due to the content of external antibacterial agents:

1. Neomycin. Belongs to the class of aminoglycosides. It has a bacteriostatic and bactericidal effect in the lesion. According to the instructions, it is effective when used externally, it suppresses pathogenic flora on the mucous membranes well. It has a wide range of antimicrobial activity, including Staphylococcus aureus - a common cause of diseases of the ENT organs.
2. Polymyxin B. Is a representative of polymyxins. It affects another class of bacteria, including Pseudomonas aeruginosa.

Both antibiotics have a pronounced effect, suppressing the spread of infection to the lower parts of the respiratory system and ear. Effective against gram-positive and gram-negative pathogens. They have no antiviral effect and are not used against streptococci and certain anaerobic pathogens.

Dexamethasone belongs to the group of synthetic glucocorticosteroids and helps eliminate allergic manifestations from infection. Inhibits inflammatory processes, prevents scarring of mucous membranes, as well as the development of erosions. Reduces the production of exudate, reduces the severity of edema.

The nasal drug Polydex also contains phenylephrine. The substance is an anticongestant, that is, it relieves swelling of the mucous membranes - the main cause of nasal congestion. The substance, when applied topically, reduces the capillary lumen, which leads to the elimination of edema and a reduction in the formation of mucous secretions.

The use of vasoconstrictor components in nasal products brings the patient quick relief by improving nasal breathing. Polydexa with phenylephrine - quickly and effectively relieves the condition by opening the nasal passages, eliminating nasal sounds caused by nasal congestion.

All components of Polydex, according to the instructions, have only a local effect and do not enter the circulatory system, therefore manufacturers do not report pharmacokinetics.

Pharmacological properties

What else does the instructions for use of Polydex ear drops tell us?

The drug belongs to the category of combined medications that have an anti-inflammatory and antibacterial effect. Neomycin and polymyxin sulfates are substances with antimicrobial activity. Neomycin is highly effective against many pathogenic bacteria, but some anaerobic microorganisms are resistant to the effects of this drug.

Polymyxin B actively compensates for this deficiency. The combination of such components makes it possible to act on a wide range of gram-negative and gram-positive pathogenic microbes, which significantly expands the therapeutic capabilities of this drug. Dexamethasone is a pharmacological group of synthetic glucocorticosteroids that have a pronounced anti-edematous and anti-inflammatory effect when applied topically. In combination with antibacterial substances, the therapeutic qualities of this medication are significantly enhanced.

Instructions for use

The use of Polydex is possible only as prescribed by the treating specialist.

Nasal spray

Polydexa in the nose is prescribed to adult patients and children over 2.5 years of age. Before injection, it is recommended to clear the nasal passages of excess mucus using a saline solution. 5 minutes after irrigation, the spray is administered into the nose. To do this, you need to pinch one nostril and inject into the other by pressing the bottle once. Repeat a similar procedure on the other side.

The use of Polydex with phenylephrine is possible for 5-10 days. It is recommended to apply one injection into each nasal passage 3 to 5 times daily.

Polydexa for children is prescribed after 2.5 years. Adults should administer the medicine into children's noses. The frequency of administration is up to 3 times a day. For patients over 15 years of age, the frequency of injections can be increased to 4 times a day.

Use during pregnancy and lactation

The use of Polydex with phenylephrine during gestation and natural feeding is not allowed - the active components through the systemic bloodstream can penetrate into breast milk and disrupt the placental barrier.

The drug can only be prescribed to this group of women by a doctor and only if the possible benefit is higher than the possible harm to the child. As a rule, the indications are severe acute infectious and inflammatory processes, the treatment of which with other medications is not effective.

Ear drops

Polydex ear drops are prescribed for a course of up to 10 days. If the medication is stored in the refrigerator at low temperatures, before administration the bottle must be warmed with the warmth of your hands or held for several minutes in a warm room.

Use during pregnancy and breastfeeding

Polydex otic is not prescribed to women during breastfeeding and gestation, since when applied locally, it is absorbed into the systemic bloodstream and penetrates the placental barrier and into breast milk. With prolonged use, it has an ototoxic effect on the child.

Doses and method of application of nasal spray and polydex ear drops

Figure 4 - It is not allowed to take Polydex without a doctor's indication.
Polydex is allowed to be used no more than 3-5 times a day, and the maximum duration of treatment is 10 days. We remind you that only a doctor can correctly prescribe a course of therapy. Although the instructions talk about undiagnosed cases of overdose and intoxication, with frequent use of Polydexa the body can get used to neomycin and polymyxin B, which will reduce the effectiveness of the drug.

So, if you follow the instructions, the dosage for adults is as follows:

• Ear drops: from 1 to 5 drops in each ear (if necessary) 2 times a day;
• Nasal spray: 1 spray into each nostril 3 to 5 times a day.

As for the dosage for children (please note that giving Polydex to children under 2.5 years of age is prohibited):

• Ear drops: 1 to 2 drops in each ear 2 times a day;
• Nasal spray: for children under 15 years of age, 1 spray is recommended in each nostril 3 to 5 times a day.

The dosage regimen and dosage should be calculated by the treating otolaryngologist, pediatrician or family doctor.

Useful tips for use

To make the use of Polydexa comfortable and the treatment to have positive dynamics, use the following useful tips. So, when you decide to use ear drops, warm them up a little by holding the bottle in your palm for a few minutes so that the solution is at a comfortable temperature. After you have dropped the product into your ear, pull back your earlobe several times. Let your head remain tilted for about 3-5 minutes. Cover the ear canals with cotton wool.

If you are using Polydex Nasal Spray with Phenylephrine, first clear the accumulated mucus from your sinuses by rinsing them with seawater or a rinse solution. Hold the spray vertically, no need to tilt your head back.

Figure 4 - Polydexa - nasal spray

Side effects

Identified side effects while taking Polydexa are itching, redness and urticaria. When using the spray, dry nasal mucosa may occur. Polydex should not be taken together with certain aminoglycoside antibiotics (monomycin, amikacin, netilmicin, gentamicin, streptomycin); it cannot be combined with guanethidine and monoamine oxidase inhibitors, since a side effect of such a complex will be intoxication of the hearing aid.

special instructions

You cannot rinse your sinuses yourself with Polydex.

It is better for athletes not to use Polydex when they are preparing for competitions, as the results of the doping test will be positive.

Storage conditions and periods

Polydexa in both forms of release is stored for 3 years, including after opening the package. Conditions: dry, dark room with air temperature no higher than 25 degrees. Do not allow children to use the drug.

Instructions and dosage of the drug

All drugs containing antibiotics and glucocorticosteroids can be used only according to indications and the recommended course. Dosages cannot be changed in any direction.

Nasal drops (spray) are prescribed for serious lesions of the nose and sinuses; herbal preparations cannot effectively replace antibiotics. The same applies to medications that are dropped into the ears.

Treatment of bacterial infections, with complicated forms of pathologies of the ENT organs, in most cases requires complex therapy; Polydexa combines well with many drugs.

For babies

No matter how great the temptation is to quickly cure a baby, you need to use age-appropriate medications for him. For green, thick snot, the doctor will prescribe a suitable spray for rinsing the sinuses. Inhalations through a nebulizer with Polydexa are also not given to children.

Children from 1 year and older

Bacterial infections of the upper respiratory tract and ear literally haunt many children. According to the instructions, the use of Polydex is possible no earlier than 2.5 years.

Indications for use in children correspond to those general for the drug. You cannot treat children by choosing Polydex on your own. The medicine must be prescribed by a doctor, he will determine how many days the drug should be used.

Directions for use and dosage:

1. Polydex, according to the instructions, is dripped into the ear twice a day, choosing an interval of 12 hours. One drop is enough for one application. Children over 15 years of age can be administered 2 drops into the ear.
2. The spray should be sprayed into the nose, one spray into the nostril 3 times a day.

According to the instructions, medications are not used in other ways.

Let us remind you that ear drops need to be warmed to a temperature of 37-38 °. To do this, you can warm the bottle in your hand or in warm water. This will improve the effect of the medicine and will not be unpleasant for the child.

For adults

In the absence of contraindications, Polydex, according to the instructions, is used for adults according to the following rules:

1. Drops in the ear. Depending on the severity of the infection, a dosage of 1-5 drops is selected in each pass with an interval of 12 hours.
2. For the nasal version, the instructions suggest administering up to 5 times a day, no more than one injection.

The usual treatment period is 6-10 days. If you cannot get rid of your runny nose during this time, you should not extend the course on your own. The doctor is told about the lack of improvement and he will choose another remedy.

Important: do not rinse the nose and ear with Polydex, and the product is not recommended for use in a nebulizer

During pregnancy and lactation

The decision to use Polydex for pregnant women, according to the instructions, is made in each case individually. In general, the drug is not recommended when carrying a child. There are other medications that are safer for the fetus.

Do not use in the first trimester. For women during lactation, if treatment with Polydexa is necessary, feeding should be stopped for the entire duration of therapy. Due to the lack of systemic action, it can be resumed as soon as therapy ends.

Indications and contraindications for use

Indications for Polydex nasal drops:

1. Rhinitis in acute or chronic form.
2. Rhinopharyngitis in acute or chronic form.
3. Sinusitis.
4. Adenoiditis in chronic form.
5. Frontit.
6. Sinusitis.

Diseases of the paranasal sinuses are characterized and named according to the localization of inflammation: sinusitis - maxillary sinuses, ethmoiditis - ethmoidal sinuses, etc.

In addition, the drug can be used after surgery on the paranasal sinuses or nasal cavity. Polydexa is also used to prevent damage to the mucous membrane by dangerous infectious agents.

These nasal drops are used as a separate component in the treatment of the disease, as well as as part of complex therapy.

Contraindications for Polydex nasal drops:

1. Hypersensitivity or individual intolerance to the components included in the medicine.
2. Viral diseases of the nasopharynx.
3. Angle-closure glaucoma.
4. Kidney diseases (renal failure, albuminuria syndrome).
5. Pregnancy and breastfeeding.
6. Age up to two and a half years.
7. Taking drugs that block monoamine oxidase.

In addition, Polydex is not suitable for rinsing the paranasal sinuses. And due to the fact that the drops contain a sympathomimetic, the drug should be used very carefully by those who have arterial hypertension, coronary insufficiency or hyperthyroidism.

During pregnancy

Polidex should not be used by pregnant or breastfeeding women.
This drug is prescribed only when absolutely necessary, when there is no alternative medicine to replace it. The instructions say that long-term use of Polydex can lead to improper formation of the hearing organs in the fetus.

When using this drug during lactation, the child must be switched to artificial feeding for the duration of treatment.

For small children

Polydexa can be used to treat sinusitis and sinusitis in children. These diseases most often occur in childhood. Sinusitis usually develops due to the penetration of pathogenic microorganisms into the paranasal sinuses, but most often the secretions contain staphylococci or Pseudomonas aeruginosa, for which this drug is very effective.

The instructions indicate that the drops are injected into the nose, but are not used to rinse the sinuses.

But many doctors use lavage when treating children in a hospital and inject Polydex into the sinuses, which gives good results. It should be remembered that this method of treatment can only be used from the age of six, strictly observing the dosage.

Polydexa is prescribed to children over two and a half years of age. But you need to make sure that the child does not swallow the medicine.

Analogues of Polydex ear drops

There are no complete analogues of this product. Therefore, the doctor should select a drug to replace it in accordance with the existing symptoms of the disease. It will be difficult to choose an analogue on your own. Ear drops that can replace medicine:

Dexona (Kadila Healthcare, India) is a combination drug in composition similar to Polydexa (neomycin + dexamethasone). Its effectiveness and safety in children, pregnant women and nursing mothers have not been proven. Costs about 120 - 150 rubles. Otofa (Bouchard Laboratory, France) is an antibacterial agent whose active substance is the topical antibiotic rifamycin. The advantage of drops is the possibility of their use in cases of violation of the integrity of the eardrum

Important: the drops will not relieve swelling, and ear pain will go away only after the bacterial process is suppressed. Otofa is suitable for the treatment of any otitis, including purulent ones with perforation of the eardrum

The drug is approved for use by children. Costs 170 – 180 rubles. Candibiotic (Glenmark Pharmaceuticals, India) is a combination product with antibacterial, antifungal, anti-inflammatory and analgesic properties. Ingredients: antibiotic chloramphenicol, antifungal agent clotrimazole, GCS beclomethasone, anesthetic lidocani. Approved for use by children over 6 years of age. Price 135 – 200 rubles. Garazon is a combination drug that includes the antibiotic gentamicin and the GCS betamethasone. Contraindicated in children under 8 years of age, pregnant and nursing mothers. The price is about 250 rubles.

In what cases is the drug contraindicated?

Before using Polydexa, parents should definitely consult a specialist. The doctor is obliged to notify the child’s relatives about the method of use, adverse reactions and contraindications to the use of the drug. The first and main limitation when prescribing Polydexa is children under 2.5 years of age. Polydexa in spray form is prohibited for use in children with:

• hypersensitivity to individual components of the drug;
• glaucoma;
• renal failure;
• hypertension and angina pectoris;
• thyroid diseases;
• together with monoamine oxidase inhibitors.

Polydex ear drops also have contraindications, which include:

• the risk of an allergic reaction to one of the components of the drug;
• hyperthyroidism and other pathologies of the thyroid gland;
• disorders of the heart, which are manifested by hypertension or coronary artery disease, as well as angina pectoris.

People's opinions

“Polydexa” is a nasal spray, the price of which is quite reasonable, considering the diseases that the medicine can cure, the reviews have been mostly positive. As the patients themselves note, the effect after using this remedy comes quite quickly: after 3-4 days, the green discharge from the nose stops, the person begins to breathe well, and the headaches go away.

Many positive responses are left by those people who have been diagnosed with chronic sinusitis. If earlier in this case, specialists prescribed surgery - puncture of the maxillary sinuses, now the treatment technique has changed. First, the otolaryngologist may prescribe the medicine “Polydex” - a nasal spray that can overcome the disease. And if this medication does not help, then the person lies on the operating table. But judging by the numerous reviews of patients who were diagnosed with “chronic sinusitis,” they did not get that far, and they limited themselves only to the “Polydex” remedy. Therefore, if you now ask those people who were treated with this medication, they will all unanimously say that now there is no question of any puncture. Such patients are grateful to the manufacturers of this medicine for the fact that now they should not be afraid of sinusitis and the surgery associated with it, because it can be avoided by purchasing the Polydex product in time.

But, despite the fact that this drug is so praised by many patients, you should not rush headlong to the pharmacy to get it. After all, this medication is an antibiotic, and also a hormonal agent. First, you should go to an appointment with an otolaryngologist, undergo all the examinations prescribed by him, and only after the doctor decides to prescribe this medicine, you can safely purchase it. And self-medication is unacceptable, especially if it concerns children.

Polydex ear drops have also earned a large number of positive reviews. Thanks to them, both adults and children quickly got rid of otitis media, and they did not experience any complications after taking this drug.

How to use Polydex for snot

Polydex is used for thick green and yellow snot in children and adults.
Nasal irrigation is carried out up to 5 times a day. The dose for children is selected by a pediatrician or ENT specialist. Typically, children (from 2.5 years to 12 years) are prescribed no more than three injections per day. For the smallest patients, the minimum dose of polydexa is recommended - 1 injection per day. The course of treatment is 5–7 days. In order for the medicinal substance to reach its destination, your head should be thrown back and remain in this position for 10 seconds.

Sometimes the doctor may offer several drugs to choose from, and patients often doubt their preference when purchasing a drug. It is worth noting that a knowledgeable specialist must clearly prescribe the drug, taking into account the patient’s condition and his purchasing power. Polydexa is also great for getting rid of snot in the throat.

If the patient has a complaint that Polydexa does not help with green or yellow snot, the drug should be replaced. In some cases, the drug isofra may be suggested.

Let's look at a case where a patient is offered to buy Polydex or Isofra for green snot.

Features of use in children

The instructions for children do not provide any age restrictions for using ear drops. But this medicine can only be prescribed by an ENT doctor after examining the ear.

It is very harmful to use it yourself in the nose at the first signs of an acute respiratory viral infection (ARVI); parents like the immediate effect of the medicine, which relieves swelling from the nasal mucosa and restores nasal breathing; but this cannot be done, because local immunity is suppressed, and this drug has no antiviral effect.

But ear drops are indispensable for otitis media. They perfectly relieve inflammation and swelling, fight infection and quickly eliminate pain. Parents whose children often suffer from otitis media appreciate this remedy as one of the most effective. But they also know that this remedy for children can be used only after examination by an ENT doctor, who must confirm the integrity of the tympanic septum.

An obstacle to the use of ear drops may be a streptococcal infection, which has characteristic manifestations. This process can involve the area of ​​the external auditory canal. The antibiotics included in the drops do not act on streptococci, and dexamethasone reduces local immunity, so the child’s condition may worsen.

Polydex nasal spray with phenylephrine is an effective treatment for adenoiditis in children over 2.5 years of age. It not only suppresses infection and inflammation, but also stops the proliferation of lymphoid tissue. The spray is effective in the treatment of sinusitis.

Contraindications

The medicine should not be used if you are hypersensitive to the action of any of its components, including aminoglycosides and parabens. Other contraindications:

• angle-closure glaucoma (confirmed or probable);
• viral nature of the infection;
• renal dysfunction, proteinuria, urinary retention;
• severe form of coronary insufficiency;
• difficult to control hypertension;
• pregnancy regardless of term;
• breastfeeding period;
• younger children (up to 2.5 years).

Caution is required in case of hypertension, diabetes, hyperthyroidism, psychotic disorders, increased convulsive readiness, ischemia, stroke or a high risk of its occurrence.

In patients with chronic atrophic rhinitis, increased atrophy of the nasal mucosa may occur.

For what diseases is it prescribed?

The nasal form of Polydex is used for complicated forms of nasal inflammation, which are accompanied by congestion, purulent discharge, and last a long time. Such diseases include:

• rhinitis of all forms - acute, chronic, purulent in children after intubation;
• adenoiditis;
• rhinopharyngitis - joint inflammation of the nasal passages and pharynx;
• inflammation of the sinuses - sinusitis (including sinusitis, frontal sinusitis).

For sinusitis, the use of Polydex allows you to eliminate infection of the maxillary sinus.

It effectively eliminates the symptoms of inflammation in children with grade 2 and 3 adenoids. The instructions allow you to use the spray in case of adenoiditis without the use of systemic antibiotics.

Ear drops

Polydex drops, according to the instructions, are used for external otitis to eliminate infection. It can also be used for eczema and traumatic injuries of the ear canal without perforation of the eardrum.

Indications for use

Polydex nasal drops are used to eliminate primary and secondary bacterial infections affecting the nasal cavity, nasopharynx and paranasal sinuses. They are appointed:

• for sinusitis and other types of sinusitis (frontal sinusitis, ethmoiditis, sphenoiditis);
• acute or chronic rhinitis;
• rhinopharyngitis;
• adenoiditis, polypous rhinosinusitis;
• rhinorrhea and nasal congestion due to allergies;
• purulent rhinitis after prolonged nasal intubation;
• infectious process as a result of surgery, including after opening of the sinuses.

Drops are used for severe disease, excessive mucus secretion, and the presence of purulent or mucopurulent exudate.

Indications

The nasal spray is easy to use and is recommended by experts for bacterial diseases of the nasopharynx. Indications for use of Polydex - various rhinitis, sinusitis, sinusitis.

With a runny nose

Often when prescribing medication, patients have a question: Is Polydexa an antibiotic or not? Definitely yes. The drug contains not one, but two antibiotics: neomycin and polymyxin.

When is the use of nasal drops with phenylephrine justified?

The use of the drug for the nose is indicated for a long runny nose, when the discharge becomes purulent in nature, and all other drops do not help. To avoid serious complications in the form of sinusitis or otitis, otolaryngologists prescribe a drug with antibiotics for local action on the nasal cavity. The combination of its active substances eliminates unpleasant symptoms in the form of profuse nasal discharge and has a destructive effect on the cause of the disease - inflammation caused by bacteria.

Instructions for use of Polydexa note that with frequent use of the spray, antibiotic-resistant strains may appear in the composition and reduce the effectiveness of the drug.

For sinusitis

For the treatment of purulent runny nose, including sinusitis, otolaryngologists quite often prescribe Polydex nasal drops.
Clinical studies of the use of Polydex for sinusitis showed the effectiveness of the drug already on the 3rd day from the start of treatment. The patients' headaches disappeared, congestion decreased and discharge stopped, pain in the area of ​​the maxillary sinuses became easier. On the 10th day, complete recovery occurred. However, experts do not advise treating such a serious disease as sinusitis without consulting a doctor and rinsing the sinuses with the specified spray yourself. The procedure for washing the maxillary sinuses with this remedy is carried out only by doctors in hospitals.

For adenoids

Polydex nasal drops are used for adenoids in children. It is usually included in the complex of conservative therapy for adenoids of the second and third degrees. The spray form is convenient for babies, which allows you to treat this disease at home without resorting to additional injections of antibiotics.

Interaction with other tools

Polydex can be used in conjunction with systemic antibiotics with the exception of Gentamicin, Streptomycin, Amikacin or other aminoglycosides. It cannot be combined with certain drugs:

1. Antidepressants from the group of non-selective MAO inhibitors. You can start treatment no earlier than 2-3 weeks after their discontinuation. Otherwise, the risk of paroxysmal hypertension increases.
2. Oral and nasal sympathomimetics. They enhance the vasoconstrictor effect of phenylephrine and can provoke a stroke or hypertensive crisis.
3. Ergot alkaloids. Hypertensive crisis is possible.
4. Local anesthetics, terpenoids, Clobutinol, Atropine. They reduce the threshold of convulsive readiness and can cause muscle spasms and an epileptic attack.

Read more Xylometazoline nasal drops: instructions for use and reviews

Polydexa may reduce the effectiveness of antihypertensive drugs. When taking Aspirin (from 3 g per day) or other NSAIDs in parallel, the risk of bleeding and ulceration of the gastrointestinal mucosa is increased.

Medical supervision is required when simultaneously prescribing a spray with antiarrhythmic drugs, laxatives, corticosteroids, as well as with intravenous administration of Amphotericin B. Vaccination against polio and tuberculosis (BCG) is recommended after completion of the course of treatment. If surgery is planned using a halogenated anesthetic (general anesthesia), the use of the medication in question should be stopped several days before.

Drug substitutes

Let's look at what medications can replace Polydex:

1. Isofra. Contains an antibiotic of the aminoglycoside group. It eliminates various types of bacterial infections well and is conveniently dosed. Can be used by children after one year.
2. Flixonase. Nasal spray containing a glucocorticosteroid. Used to treat allergic rhinitis.
3. Rinofluimucil. Has the same scope. Does not contain antibiotic. It relieves swelling in the nasal passages well, as it contains a vasoconstrictor component. Not for use in children under 3 years of age.
4. Vibrocil. Has several nasal forms. Used as a decongestant and anti-inflammatory agent. Used for rhinitis and sinusitis. Well tolerated by patients. Has antiallergic effect.
5. Garazon. Ear drops contain an antibiotic (gentamicin) and corticosteroids. Due to this, they have a pronounced anti-inflammatory and anti-edematous effect.
6. Candibiotic. Drops in the ear have an antifungal effect and antibacterial activity. Contains lidocaine, which is good for relieving ear pain. According to the instructions, it is allowed from 6 years.

There are no exact analogues of Polydex, therefore, despite the fairly high price (more than 300 rubles), many choose this drug for treatment.

According to doctors' comments, the medicine helps well with sinusitis, rhinitis, including those with allergic components. Many otolaryngologists prescribe Polydex for adenoiditis, noting the absence of negative reactions and good tolerance by children.

The medicine is conveniently dosed, the effect is observed after 2-3 days of use. Patients are also satisfied with the quick results of treatment. The French drug has proven itself well in the treatment of complex diseases of the ENT organs.

Polydexa in the nose: contraindications and side effects

Since the composition of Polydexa is multicomponent, containing 2 antibiotics, it is suitable for eliminating rhinitis and sinusitis, but still has a list of contraindications. The product cannot be used:

• children under 2.5 years old;
• in the presence of closed-angle glaucoma;
• nursing mothers, pregnant women;
• when using MAO inhibitors;
• for diseases of the nasal passages of a viral nature;
• in case of intolerance to the constituent components;
• for glaucoma;
• with kidney disorder, renal failure.

On a note! People with hyperthyroidism, namely: angina pectoris, blood pressure, and ischemic pathology, need to be careful. Be careful when simultaneous treatment with medications that contain aspirin.

Side effects were only observed on the skin: itching, redness, rashes, irritation, urticaria.

Analogs

Currently, there are no identical generics of Polydex with phenylephrine. So far this is the only drug that combines both antibacterial and vasoconstrictor effects.

Incomplete analogues:

1. Bioparox is an antibacterial drug for the treatment of the upper respiratory tract. The active substance is fusafungine. Prescribed as local therapy for acute inflammatory processes of the respiratory tract, upper respiratory organs, ENT organs of an infectious nature, namely rhinitis, nasopharyngitis, sinusitis, laryngitis, pharyngitis, tonsillitis and bronchitis. Bioparox is used intranasally. The drug should not be prescribed to children under 2.5 years of age. During pregnancy and lactation, the use of Bioparox is possible if the expected benefit of the therapeutic effect of the drug is higher than the risk to the child. The course of treatment should not last longer than 7 days.
2. Isofra is a local antibacterial agent with an active bactericidal effect, widely used for the treatment of ENT diseases. The active ingredient is framycetin sulfate. The indication for the use of the drug Isofra is the treatment of infectious and inflammatory pathologies of the upper respiratory tract, in particular rhinitis, rhinopharyngitis, sinusitis, as well as the prevention of secondary infection and treatment of inflammatory phenomena after surgery on the ENT organs. The product is available in the form of a spray and is used intranasally. Isofra spray can be used to treat children and adults according to an individual regimen. The average course of treatment is no more than 7 days.

Before using analogues, consult your doctor.

Polydexa or Isofra - which is better?

Manufacturer: Sofartex, France
Release form: nasal spray

Active ingredient: framycetin

Synonym: Tramicent

Isofra is an analogue of Polydex nasal spray, containing one component - framycetin. Refers to antibacterial drugs, affects pathogenic sensitive microflora - gram-positive and gram-negative bacteria. The medicine is used for sinusitis (sinusitis), nasopharyngitis, rhinitis, green snot, and adenoids. The price of the medicine is slightly lower than Polydex - 330–440 rubles.

Polydexa contains two antibiotics that enhance each other, and a glucocorticosteroid with pronounced anti-inflammatory properties. The composition of the drug is more effective and stronger. An additional substance is phenylephrine, which normalizes breathing by constricting blood vessels and eliminating redness and swelling of the nasal mucosa.

What is best for a child is individual. Both drugs are prescribed by a doctor and are available with a prescription.

Difference between drugs:

• composition – Isofra has only an antibacterial effect, Polydexa has an antibacterial, anti-inflammatory, vasoconstrictor effect;
• due to its composition, Isofra is used in pediatrics from the age of 1 year, Polydexa - from 2.5 years, strictly as prescribed by the doctor;
• an analogue of Polydex spray with Phenylephrine Isofra is slightly cheaper - up to 50 rubles;
• Polydex has more contraindications for use than its analogue.

Both medicines are effective, imported, and of high quality. The choice in favor of one or the other is made by the doctor based on medical history. The undoubted advantage of the medicines is that they are original. This means that they have been sufficiently studied, there is clinical research data on the safety and effectiveness of using nasal spray in adults and children.

Dosage

Children should take Polidexa (nasal spray) with caution. Reviews from doctors show that side effects occur only when parents do not adhere to the dosages recommended by the pediatrician. Children under 15 years of age are prescribed no more than 1 injection of the drug once a day. For the treatment of adults, the dosage may be slightly increased. The maximum daily dose is 3 injections into each nasal passage 3 times a day.

The drug has a low degree of absorption. In this regard, there can be no overdose. In rare cases, only hypersensitivity to individual components develops. If any adverse reactions occur, you should consult your doctor. Dose adjustments or complete discontinuation of the drug may be necessary.

How to take Polydexa during pregnancy

You can purchase this medicine with a doctor's prescription.
This condition is necessary to prevent self-medication and the occurrence of negative consequences. The method of taking the drug is injection into each nasal passage . When injecting, the bottle is held vertically, it is recommended to tilt your head slightly forward for better penetration into the mucous membrane.

It should be noted that before injection, the nasal passages must be thoroughly rinsed to increase the effectiveness and area of ​​effect. Please note that rinsing your nose with the drug is prohibited.

The daily and single dose of the medicine, as well as the duration of administration, is determined and adjusted (depending on changes in the clinical picture) by the doctor.

Use during pregnancy and lactation

Treatment with this medication during pregnancy is unacceptable. The reason for this is the insufficient evidence base regarding the safety of this drug for the fetus. However, if other medications aimed at treating the above pathologies turn out to be ineffective, the use of Polydex is possible only in situations where the likelihood of a negative effect on fetal development is lower than the positive effect on the patient’s health.

Substances present in the composition of the drug "Polydex" may be contained in mother's milk, which, in turn, will negatively affect the health of the child. For this reason, the use of the drug during this period is also not allowed. Otherwise, it is recommended to interrupt the lactation process. All this is confirmed by the instructions for Polydex ear drops.

What Polydexa contains and how it works

A common cold during pregnancy can lead to the development of an infectious process, which requires the use of antibacterial agents. These drugs include Polydexa. The product is available in two forms:

• nasal spray;
• ear drops.

The drug in the appropriate form is capable of inhibiting the vital activity of gram-positive and gram-negative bacteria in the nasal cavity or in the ear canal. This combination remedy is often used in otolaryngology and is considered quite effective.

Polydexa can relieve nasal congestion

The therapeutic effect is provided by the active ingredients of the drug. Common active ingredients include:

• neomycin sulfate;
• polymyxin B sulfate;
• dexamethasone sodium metasulfobenzoate.

The nasal spray contains another active component - phenylephrine, which has a vasoconstrictor effect on the nasal mucosa, relieving nasal congestion.

Polydexa is available in the form of ear drops and nasal spray.

Neomycin and polymyxin B are antibiotics. Thanks to the combination of two types of antibiotics in one medicine, a broad antibacterial effect is provided. At the same time, the drug does not affect the microorganisms Streptococcus spp. Dexamethasone complements these components, providing an anti-inflammatory effect.

Common auxiliary components:

• lemon acid;
• macrogol;
• polysorbate;
• purified water.

The composition of the ear drops is supplemented with thiomersal and sodium hydroxide solution. The nasal spray contains methylparaben, lithium chloride, lithium hydroxide.

Composition and action

Nasal spray has a pronounced effect against harmful microorganisms and bacteria. Such organisms become the root cause of the development of undesirable processes in the respiratory tract and nasal sinuses. The drug quickly relieves acute signs of the disease and improves breathing within five days.

The therapeutic result is based on the substances included in the composition:

1. Dexamethasone. Characterized by an antiphlogistic effect.
2. Neomycin. An antibiotic that is effective against staphylococcus, E. coli, and Haemophilus influenzae.
3. Polymyxin. It is characterized by antibacterial effects against Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.

The main substances complement each other and expand the range of effects on a large number of gram-positive and gram-negative microflora. Such floras become the root cause of the progression of inflammatory processes in the nasal cavity. The medication has a destructive effect on the membrane membrane of pathogenic organisms. Streptococci and anaerobic flora are resistant to the product. Polydexa and its analogues are prescribed for:

• sinusitis;
• sinusitis;
• congestion;
• adenoids;
• runny nose;
• infected eczema of the ear canal;
• purulent-catarrhal exacerbations;
• front.

It is produced in the form of drops in the nose and ears, and spray. Only the attending physician should prescribe the drug. The diseases that are indications for using the drug are very serious. If treated incorrectly, exacerbations are possible. Polydex drops with phenylephrine have a complex composition, so it is important to follow the indicated dose and frequency of administration.

Storage conditions and periods

As the manufacturer indicates, the shelf life of Polydex drops is 3 years. But we are talking about a closed bottle. If we talk about how long the drug is stored after opening the package, then all its medicinal properties are preserved for 30 days, subject to the rules for storing the medicine.

Regarding the storage conditions of the drug:

• storage temperatures – no higher than 25°C;
• freezing of the drug is not allowed;
• storage out of the reach of children and pets.

The manufacturer does not recommend using the drug after its expiration date.

Polydexa: properties, composition, cost of the drug

Polydexa is a combination drug that is used topically.

The therapeutic effect of Polydexa is based on the components included in its composition:

• dexamethasone has an anti-inflammatory effect;
• neomycin is an antibiotic active against staphylococcus, Escherichia coli, Klebsiella pneumoniae and Haemophilus influenzae;
• Polymyxin B also has antibacterial properties against Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Haemophilus influenzae.

Complementing each other, the active components of Polydex expand the joint spectrum of influence on the overwhelming number of gram-positive and gram-negative microflora, which provoke the development of inflammatory processes in the nasal cavity, as well as in the middle and outer ear.

The drug has a destructive effect on the membrane membrane of pathogenic microorganisms and causes the death of cellular structures. Dexamethasone, which is part of Polydexa, reduces the permeability of the capillary network and stops the synthesis of inflammatory enzymes. Streptococci and anaerobic flora are resistant to Polydex.

Indications for use of the drug are:

• external and otitis media;
• infected eczema of the ear canal;
• rhinitis, sinusitis, sinusitis, purulent-catarrhal complications.

Any drug with an antibacterial and anti-inflammatory spectrum of action should be prescribed by a doctor. The diseases that are indications for the use of Polydex are serious and unpredictable; if treated incorrectly or late, they can cause serious complications.

Polydexa has a complex composition; when treating with this drug, it is important to take into account the recommended dosage and the general course of treatment prescribed by the doctor. The specialist also takes into account the patient’s age, the severity of his illness and related health problems. That is, there can be no talk of any self-medication in the case of Polydexa.

The cost of Polideksa nasal spray varies from 300 rubles. The price of drops ranges from 200 rubles.

How effective is Polydex nasal spray in treating children?

1. Polydex nasal spray belongs to a new generation of drugs, and is currently the most effective and efficient when used locally. Positive reviews among patients speak of the impressive effectiveness and rapid results of treatment.
2. According to studies, in patients with sinusitis, already on the 5th day of using the drug, nasal discharge stopped, headache and pain in the maxillary sinuses, and nasal congestion disappeared. And on the 10th day of using the drug, clinical recovery occurred.

Side effects

Adverse consequences of therapeutic procedures using ear drops occur very rarely - in isolated cases. In this case, allergic reactions of a local nature may be observed, for example, hives, rashes, itchy skin. If the drug is used in large dosages, which implies the penetration of its active components into the blood, then headaches, sleep disturbances, increased heartbeat, tremors of the limbs, increased blood pressure, pallor or redness of the skin may cause concern.

For Polydex ear drops, the instructions for use must be strictly followed.

Let's summarize

Summarizing all of the above, let's summarize:

1. Polydex drops are a complex medical product that simultaneously contains 2 antibiotics. Due to this, the spectrum of action of the drug is very broad. It simultaneously eliminates the inflammatory process and has a negative effect on the fungal microflora that parasitizes the auricle.
2. The main indication for taking Polydex drops is otitis and other infectious and inflammatory diseases of the ENT organs, which provoke complications in the ears.
3. Polydex drops should only be used externally. And due to the fact that they are almost not absorbed into the skin tissue, the risk of developing an adverse reaction and overdose is practically absent.
4. The medication is approved for use only after consultation with an otolaryngologist. Only a qualified specialist can determine the etiology of the disease and select appropriate therapy. Self-medication is dangerous to health, and in some diseases, even to life!

Take care of your health and take care of it in a timely manner!

Contraindications to the use of Polydex during pregnancy

Contraindications to the use of the medication described in this article include:

1. Under no circumstances should you take Polydex in the first trimester of pregnancy.
2. You cannot be treated with Polydexa if you are allergic to any component of the drug. Therefore, before you start using it, check your sensitivity to phenylephrine, polymyxin B and neomycin, because hypersensitivity to these components may occur during pregnancy.
3. Polydex should not be used if the pregnant woman has closed glaucoma or if the liver and kidneys are not functioning properly.

Application specifics

In order for a medicine to help in the fight against a particular disease, you need to know how to use it correctly.

Before direct use of the drops, it is recommended to test for allergies to the active substances of the medicine. To do this, apply a few drops of the medication to the wrist and monitor the reaction of the skin. If, after 3-10 hours, no rashes, hives, redness have appeared on the skin, or it has not begun to itch or burn, then you can use the drops for their intended purpose, without fear of developing an allergic reaction. If allergy symptoms are present, you should consult a doctor to replace the drug with another one.

Polydex ear drops are used according to the following scheme:

1. The first step is to wash your hands thoroughly to prevent bacteria from reaching the site of infection.
2. After this, we prepare the medicine itself for use. Before using it, the composition must be heated to a temperature of 35-36°C. The easiest way to warm it up is to hold it in your hand for 3-5 minutes. Applying cold medicine to an inflamed ear can lead not only to an unpleasant sensation, but also to a worsening of the current condition of the disease. Moreover, with the systematic use of cold medicine, complications of an existing disease may develop.
3. Next, the patient lies on his side, with the affected ear facing upward. The dispensing pipette is inserted into the ear no deeper than 5 mm.
4. After instillation, a cotton swab is inserted into the ear, preferably pre-coated with Vaseline, and the patient remains in the original position for another 5-10 minutes. This will prevent evaporation of the drug and allow it to be distributed as best as possible throughout the infected tissues of the ear cavity.

If, upon completion of the course of treatment, no improvement is observed, then you should consult a doctor to replace the drug with another, more effective one.

Application, dosage

Attention! The data provided in the publication is for informational purposes only. You should not take them as a basis and take the drug according to the indicated regimens without first consulting a specialist. Only a doctor can prescribe proper treatment!

How to take Polydex drops for otitis and any other infectious and inflammatory diseases of the ENT organs is prescribed by a doctor. The duration of the course, according to these instructions, is no more than 10 days. The manufacturer does not recommend exceeding the specified period of use of the drug, since this can cause pathogenic microorganisms to become addicted to the active substances and, due to this circumstance, they can continue to multiply.

As for the frequency and dosage of taking Polydex drops. The annotation contains average statistical data. Let's look at them in more detail.

Use of the drug in adults

As indicated in the instructions for use of the drug, Polydex ear drops are taken by adults according to the following regimen: 2 drops 2 times a day. In case of severe illnesses, the number of drops increases to 5. But, again, all this is purely individual.

How to use Polydexa for children

Polydex drops for children are prescribed only by a doctor. It is strictly forbidden to use the drug yourself without prior consultation with a specialist.

The dosage regimen for children is as follows: 1-2 drops into the infected ear twice a day. It is worth adding here that treatment with Polydex should be constantly monitored by both parents and the attending physician.

Treatment with drops for children under 3 years of age

The instructions for use of the drug Polydexa do not contain any information regarding the age at which these drops can be used in the ears. Therefore, in pediatric practice, sometimes doctors prescribe the drug to babies even in the first year of their life.

As practice shows, Polydexa does not cause pronounced adverse reactions in children, provided that treatment with the drug is supervised by a specialist and carried out strictly according to the doctor’s instructions.

Use during pregnancy

Polydex drops for otitis media are not prohibited for use during pregnancy. In medical practice, they are often prescribed to pregnant women in order to eliminate infectious and inflammatory diseases of the ENT organs.

Safety is due to the fact that the active components of the drug, despite the fact that they are powerful antibiotics, are practically not absorbed into the mucous tissue of the auricle and, accordingly, they do not penetrate the bloodstream and the patient’s body.

However, prescribing the drug by doctors during pregnancy must take into account all the risks for the fetus developing inside the mother. Most often, this is a short-term treatment regimen. So, after the condition improves, the patient stops taking antibiotics. Long-term use of drops, according to some clinical studies and data described in the annotation, can provoke the development of deafness in the fetus.

Can the drug be used during breastfeeding?

The instructions for use of the drug do not contain any data on the prescription of the drug to patients during lactation. Consequently, there is no data on the safety of the drug in relation to children.

The use of Polydex drops during breastfeeding is undesirable and is permitted by otolaryngologists only if absolutely necessary. Moreover, most often, experts strongly recommend temporarily interrupting breastfeeding.

Side effects

Despite the fact that the components of the drug are practically not absorbed into the mucous tissues of the auricle, the following adverse reactions of the body may develop with prolonged use of Polydex:

• headache;
• fast fatiguability;
• sleep disturbance;
• decreased appetite;
• hypertension;
• allergic reaction - itching, burning, redness, rash, hives, etc.

It is also worth noting that the drug Polydex is available not only in the form of drops, but also in the form of a nasal spray. When using the latter, much more serious side effects may occur:

• dry sinuses;
• tachycardia;
• pallor and redness of the skin;
• tremor in the limbs.

In most cases, an adverse reaction of the body to a medication appears only in the case of an uncontrolled and long-term course of use. By following all the doctor’s prescriptions, there are practically no side effects.

Side effects and overdose

General negative manifestations are rare, since the instructions indicate that the components do not pass into the bloodstream. Among the possible ones, which are observed extremely rarely, the following have been identified:

• increased heart rate;
• tremor;
• headache;
• anxiety and sleep disorders;
• increase in blood pressure.

With the development of local reactions, dryness and burning of the mucous membranes and urticaria are possible.

The use of local remedies does not lead to overdose.

Method of application and dosage

The medication is very popular among patients and specialists in otolaryngological hospitals, since this form of medication is very easy to use and has a small list of side effects that appear only in isolated cases. Reliable information about drug overdose has not been observed in clinical practice.

As the instructions for use indicate, Polydex for the ears is prescribed in a dosage of 1-2 drops into each ear canal twice a day. For appropriate medical indications and severe pathological process in adults, the volume of the pharmacological agent used can be increased to 5 drops. Before carrying out therapeutic manipulations, it is recommended to warm the drug to room temperature.

The use of the drug "Polydex" in pediatric practice is practically no different from the rules for use in adults. So, the children's dosage is 1-2 drops into the ear canal 2 times a day.

Pharmacology

Polydex ear drops are available in liquid form, resembling an oily solution. The capacity of the original bottle is 10.5 ml. Each bottle of the drug is equipped with a pipette with a dispenser, which significantly simplifies the instillation procedure.

Polydex ear drops, in most cases, are the basis of a therapeutic course in the fight against inflammatory diseases of the ears caused by the development of pathology of any of the ENT organs. Their effectiveness is due to the combined composition:

• dexamethasone – helps relieve the inflammatory process;
• neomycin and polymyxin - have an antimicrobial effect on pathogenic microorganisms of fungal microflora.

Thanks to the combination of these antibiotics, the drops have a wide spectrum of action against most gram-positive and gram-negative microorganisms that cause infectious and inflammatory diseases of the hearing organs.

It is worth adding here that Polydex is practically not absorbed into the mucous membrane of the auricle. They act locally. And this minimizes the development of any side effects.

Course duration

The duration of the course of conservative treatment is 7–10 days. Ear drops are not recommended for use if the eardrum is perforated. In this case, there is a high probability of toxic effects of the active components of the drug on the vestibular or auditory system.

According to the instructions for use, Polydex ear drops should be used with caution if a viral or fungal etiology of the disease is suspected. It is recommended to carry out additional diagnostic studies before starting conservative therapy.

Among the active components of this pharmaceutical drug there is dexamethasone, which is a biologically active substance that can give positive results during doping control: with a long course of treatment or doses significantly higher than those recommended in the instructions (the components may have a systemic effect).

Polydexa in the treatment of upper respiratory tract diseases

Polydexa is a new generation combination drug that is highly effective and has the following actions:

• bactericidal;
• anti-inflammatory.

These effects are achieved thanks to a unique composition, which includes a combination of antibiotics and phenylephrine.

Phenylephrine significantly improves breathing through the nose, as it has a vasoconstrictor effect, thereby reducing swelling of the mucous membranes and mucous secretions.

The presence of polymyxin B and neomycin in the composition causes:

• effective local action against infections caused by gram-negative and gram-positive microorganisms;
• combating opportunistic flora, which is especially important when the immune system is weakened.

Since the drug has a local effect, doctors quite often prescribe this drug. Polydexa is relatively safe during pregnancy.

Side effects

The most common side effects in pregnant women include:

• dizziness;
• nausea and vomiting, changes in appetite;
• headache;
• tremors of the limbs;
• fluctuations in blood pressure;
• tachycardia;
• skin pigmentation;
• sleep disorders.

If, as a result of taking Polydex, the above symptoms or a deterioration in general health occur, you must urgently consult a doctor who will correct the treatment.