The use of antispasmodics (relieving spasms) is an important component in the treatment of all kinds of spasms and colic. Such conditions are especially common in the digestive system. Trimedat and Duspatalin are among those drugs that can eliminate most of these symptoms.
pharmachologic effect
The drug begins to act on the gastrointestinal tract 1.5 hours after taking the tablet (duration of action - 5 hours). It is believed that for an effective systemic effect on the entire digestive system, it should be taken three times during the day. After administration, trimebutine begins to normalize the contractility of the stomach muscles, affecting the layers of the epithelium.
The speed at which food bolus leaves the stomach is optimized. The pressure of the esophageal sphincter on the stomach is normalized, which prevents the backflow (reflux) of food and acid into the esophagus, leading to vomiting, heartburn, and nausea. This ensures relief of stomach pain.
Trimebutine restores and stabilizes the lost physiological activity of the intestinal muscles (peristalsis), which is often the cause of ailments of the digestive system. "Trimedat" evens out and coordinates the intensity of muscle contractions and movements of all parts of the long intestine. Food begins to move through it at a speed optimal for the body.
As a result, daily bowel movements are carried out more naturally and easily, and the response of the colon to food irritants is optimized. The biological availability of the active substance does not exceed 6%. It accumulates and decomposes in the liver, and is excreted in the urine (about 70% in the first day).
Release form and composition
The main active ingredient of Trimedat is the antispasmodic trimebutine. Additional components are:
- colloidal silicon dioxide,
- magnesium stearate,
- lactose,
- talc,
- corn starch.
Tablets are sold in packs of 10, 20 and 30 pieces. Only the main component trimebutine may contain different amounts - 100 and 200 mg.
The concentration of the active substance reaches its maximum an hour and a half after taking the tablet.
During this period, it is completely absorbed into the blood. The largest part of it is excreted per day along with urine. You can take the tablets for a long time, since they do not negatively affect the kidneys.
Indications for use
The doctor makes an appointment and directs the correct treatment. Symptoms susceptible to the effects of the drug may occur in the following cases:
- various ailments in the stomach and intestines with unexpressed symptoms;
- absence of a surgically removed gallbladder;
- deviations in the functions of the gallbladder (stones in the canals and organ, variations in the volume of bile secreted when the ducts narrow/expand);
- stomach/intestinal ulcers;
- therapy after surgery (against the background of constipation, intestinal obstruction);
- colitis, gastritis;
- diarrhea, constipation that do not have an infectious component;
- preparation for endoscopic and x-ray examinations;
- severe food poisoning, painful cramps;
- flatulence, bloating, when the pain is localized in the upper abdomen;
- dyspepsia, including in children, in which pain, vomiting, nausea, intestinal colic, constipation, rumbling in the abdomen, and diarrhea are observed;
- severe irritability, intestinal spasms;
- uncomfortable heaviness in the stomach, especially when eating fatty, spicy foods with spicy spices;
- gastroesophageal reflux disease, etc.
Pharmacokinetics of the drug
Trimedat is often used to relieve symptoms of gastrointestinal diseases. The drug detects its highest concentration 0.5-1.5 hours after taking the drug. During this time, it is absorbed in the intestines and penetrates the blood. Most of the drug is excreted in the urine in the first day. However, it does not have a cumulative ability and does not exhibit toxic effects on the kidneys, so the product can be used for a long time.
Trimebutine is able to regulate gastrointestinal motility, acting in isolation on the enkephalinergic system. In case of intestinal hypotension, it stimulates its work, and in hyperkinetic conditions, it effectively relieves spasms of the intestinal walls and relaxes the smooth muscles of the gastrointestinal tract.
With insufficient secretory activity of the pancreas, there are often situations when the absorption of food slows down and it stagnates in the stomach. Such phenomena reduce the motor activity of the intestine and lead to the growth of pathogenic flora in it. In such cases, gastroenterologists usually recommend taking Trimedat.
It has the necessary effect, significantly improving the patient’s condition:
- relieves pain and discomfort in the abdomen, eliminates cramps and bloating;
- improves intestinal motility in the presence of problems with stool;
- eliminates motility disorders of the sphincter of Oddi and the biliary tract, eliminates congestion in the gastrointestinal tract;
- improves the transportation of food masses;
- alleviates the patient's condition with postoperative intestinal obstruction.
Due to this effect of the drug on the gastrointestinal tract, it can help with the following symptoms:
- unstable stool;
- feeling of heaviness in the stomach;
- nausea or vomiting;
- discomfort under the left rib or upper abdomen;
- IBS.
Trimedat is widely used for both therapeutic and diagnostic purposes. It is used to prepare the patient for diagnostic measures to examine the abdominal cavity (endoscopy, x-ray).
The active substance of Trimedat, trimebutine maleate, is part of the group of myotropic antispasmodics. It affects the contractility and tone of the smooth muscle structures of all digestive organs from the esophagus to the rectum. It has been proven that the site of the pharmacological mechanism of action is numerous receptor sites in smooth muscles. They exchange mediators responsible for ensuring the movement of food.
Remembering the anatomy, we note that the pancreas is a parenchymal (not hollow) organ, like the stomach and intestines. It does not have a pronounced muscle wall, but is covered with a capsule. How does Trimedat work in this case?
One of the main pathogenetic causes of pancreatitis is considered to be obstruction of the pancreatic ducts (stones, tumor, cystic formations). Stagnation in the neighboring duodenum, transverse colon and stomach compresses the gland mechanically.
The secretion excretion system consists of small tubules, larger ones merging with each other. At the border with the duodenum, the overall release of pancreatic juice and bile into the intestine depends on the state of the muscular sphincter (sphincter of Oddi).
It is the walls of the ducts that include smooth muscles and form waves of peristalsis. Trimebutine acts on them, restoring patency and the release of enzymes into the intestines.
The main cause of acute pancreatitis is the inability to promote enzymes, stretching and stagnation in the lobules of the gland, release of enzymes into the tissue and self-destruction of the organ. In a chronic process, inflammation forms areas of connective tissue (scars) that are unable to produce enzymes. Pancreatic insufficiency gradually develops. The effect of trimebutine on the movement of digestive juices into the intestines helps restore impaired digestion, absorption of nutrients, and their entry into the bloodstream.
What does the manual contain?
The instructions for use describe the nuances of dosing and use of the drug, the consequences of an overdose, the possibility of using the drug when carrying a child and breastfeeding, and features of interaction with other medications.
Application and dosage
The dosage of the drug is prescribed by the doctor.
The drug "Trimedat" is prescribed to adults and children. The dosage should correspond to the age category of the patient. The following dosages have been established:
- people aged 12 years and older - one tablet containing 100 (200) mg of trimebutine (depending on the condition) three times a day;
- children from 5 to 12 years old - 50 mg (1/2 tablet of the minimum dosage) three times a day;
- for children from 3 to 5 years old - 25 mg (1/4 tablet of the minimum dosage) in three doses during the day.
The duration of the course is set depending on the patient’s condition and the characteristics of the disease (the standard dosage may be reduced).
How to take Trimedat for stomach pain?
Taking Trimedat 0.5 hours before meals prepares the digestive system for the passage of food. The tablet (part) is not chewed and washed down with 150 ml of warm water. The pain syndrome is relieved by taking the drug after eating (within 20 minutes).
When an exacerbation occurs, the maximum dose can be up to 600 mg per day (three 200 mg tablets). It is observed for 4 weeks. Subsequently, treatment continues for a 12-week course with a daily dose of the drug of 300 mg, which ensures the suppression of possible relapses.
Taking pills should always be accompanied by a diet (boiled, steamed and oven-baked food, fatty, spicy, floury, fresh fruits and vegetables are excluded). Long-term (many years) use of the medication is carried out in cycles. They take breaks of 2-3 months duration.
Use during pregnancy and breastfeeding
Take medication only as prescribed by your doctor.
During the first trimester of embryo development, when all systems and organs are formed, the drug is not used, since there is no information about its effect on this process, and the organisms of the mother and fetus are combined. Subsequent use is possible, but not advisable, although the regimen and dosage are standard (as prescribed by a doctor). The increased sensitivity of a woman’s body during this period can cause allergies, skin itching and redness, although this may not have manifested itself earlier (before pregnancy).
For mothers feeding their newborns with breast milk, the medicine is prescribed in emergency cases, when the risk of exposure to the baby is less than the possible benefit from taking it by the mother. During this period, the baby is weaned and transferred to a different diet. There are no reliable official data on the safety of using the product during this period.
Overdose
Exceeding the dose is expressed by increased side effects. When it is detected, treatment appropriate to the situation is carried out. There is no special antidote.
Interaction with other drugs
There are no data on interactions with other medications. However, the presence of milk sugar in the medicine should be taken into account, which is important for patients with diabetes to know. Taking Trimedat along with other drugs can lead to an increase/weakening of the effect of their components on the body. Although combining the intake, for example, with “Phosphalugel”, “Almagel”, “Rennie”, “Gastal”, “Creon”, “Omez”, “Festal”, etc., is allowed within the prescribed therapy.
Contraindications
Trimedat is one of the few drugs that has virtually no contraindications. It is not used only for the treatment of children under three years of age and adult patients suffering from intolerance to its individual components. Practice shows that there are very few patients intolerant to this drug: as a rule, it is very well tolerated by the body.
It is not advisable to take the drug in the first three months of pregnancy, as well as during breastfeeding.
Since no one has conducted research on the effect of the drug on the body of an infant, using it during this period would be an unjustified risk.
In case of emergency, if the mother’s health condition does not allow further delay of drug treatment, the baby is temporarily transferred to an artificial formula.
Trimedat cannot be combined with alcoholic beverages. During treatment, patients should completely abstain from alcohol.
"Trimedat" for children
The drug is not prescribed to children under 3 years of age. For older children, it is indicated in the appropriate age dosage (regardless of the type and severity of the illness) for dyspeptic symptoms (heartburn, diarrhea, constipation, abdominal pain and bloating, heaviness in the stomach). They can appear after overeating, introducing new foods, carbonated liquids into the diet, acclimatization, or excess nervous and physical activity. The course of taking the medication (usually one to three days) is stopped when the symptoms of indigestion disappear.
Longer courses of medication use (from 30 to 60 days) are prescribed when the following are diagnosed:
- pancreatitis;
- gastroduodenitis;
- gastritis;
- gastroesophageal reflux disease, etc.
An age-specific tablet dose can be turned into powder and mixed with water (juice) and given to a small child to drink. For children, the drug is prescribed only by a doctor.
Reviews about the drug
The medicine receives positive reviews from patients in more than 90% of cases. This is explained by its high effectiveness in the occurrence of dyspeptic symptoms, as well as ease of administration. The tablets quickly eliminate spasms in the intestines, relieve colic, abdominal pain, relieve gas accumulation, “start” the stomach, and speed up the passage of food into the intestines.
Trimedat as an antispasmodic has a rapid effect even in severe pancreatitis. Many patients, when choosing which works better for pancreatitis, Duspatalin or Trimedat, note that the effectiveness of the second drug is higher. Although Duspatalin is considered one of the most effective drugs for spasms in the gastrointestinal tract.
Sources
https://gastrolekar.ru/pankreatit/trimedat.html https://pankreatit03.ru/trimedat-pri-pankreatite.html https://ogkt.ru/preparaty/trimedat-pri-pankreatite.html https://pankreatit .guru/lechenie/preparaty/spazmolitiki/trimedat https://pankreatita.net/blog/lekarstva/spazmolitiki/trimedat https://prozkt.ru/lekarstvennye-preparaty/trimedat-pri-pankreatite.html https://pankreotit- med.com/trimedat-pri-pankreatite-otzyvy-instrukciya/ https://pillsman.org/28098-trimedat-pri-pankreatite.html
"Trimedat" for constipation
Delayed bowel movement for up to 2 days or more requires intervention with drugs that will restore healthy bowel movements (once a day). "Trimedat" quickly normalizes the condition when the situation is not accompanied by chronic constipation or neoplasms in the intestines. In addition, the drug promotes the generation of neuropeptides (enkephalins) by the nervous system, which provide pain relief and restoration of optimal motility of the intestinal muscles. The patient regains calm.
Side effects
Skin allergic manifestations of varying strength are possible.
The drug has no identified side effects. However, it is rare, but cases have been noted:
- the appearance of unmotivated anxiety;
- decreased hearing sensitivity;
- irregularities in the menstrual cycle;
- skin allergic manifestations of varying strength.
Such manifestations are largely caused by individual intolerance to the components of the drug.
Analogs
There are drugs on sale that are similar to Trimedat in terms of the active substance (trimebutine maleate) or have similar pharmacological effects. However, replacement should be agreed with your doctor, since medications may contain components that the body will not accept. The following have a similar medicinal effect:
- "Enterosan";
- "Spakovin";
- "Spazmonet Forte";
- "Eglek";
- "Novo Passit";
- "Papaverine";
- "Spazmonet";
- "Platifillin";
- “No Shpa”, “No Shpa Forte”;
- "Mukofalk";
- "Meteospasmil";
- "Neointestopan";
- "Irmalax";
- "Duspatalin";
- "Galidor";
- "Betamax";
- "Bactistatin";
- "Neobutin";
- "Sparex";
- "Tridat Forte" etc.
