Creon is often used for pancreatitis, but it can only be used as prescribed by a doctor. This drug has established itself as an effective drug that restores the function of the pancreas and the general functioning of the digestive tract.
Pancreatitis is an inflammatory process of the pancreas, as a result of which the functioning of the entire body is disrupted. It is treated with medication and diet.
The pancreas is an important organ in the general digestive system and is responsible for the high-quality digestion of food and its breakdown into substances, while removing waste and toxins from the body. If this organ suffers, then the process of secreting digestive secretions is disrupted and some of the food is not processed, settles at the bottom of the stomach and triggers negative processes leading to the development of bacteria and the destruction of microflora. Such problems lead to serious health problems. The pancreas begins to deform, and if treatment is not started in time, it will atrophy.
Treatment must be comprehensive and take place strictly under the supervision of a doctor during the course of treatment, and even after it the patient must follow a special diet. Among medications, the multienzyme drug Creon, which allows the body to start the process of secreting digestive secretions and restore the functioning of the entire system, has received good reviews.
Thanks to the properties of Creon, food is processed efficiently, there is no stagnation, it passes from the stomach to the intestines, and the process of breaking down carbohydrates and fats is accelerated.
The active substances of this drug, such as lipase, protease, amylase, are digestive enzymes and can restore the pancreas and the functioning of the entire gastrointestinal tract system.
Important information: Is it possible to drink chicory for chronic pancreatitis?
How to choose the right drug
Enzyme replacement treatment is the only option that can be used to prevent the formation of scarring and degenerative changes in the tissues of the pancreas, as well as to reduce the intensity of pain and eliminate digestive disorders. The range of pancreatin preparations is very large, but for chronic pancreatitis the most important selection criteria are:
- levels of lipase, amylase and proteases;
- the most suitable dosage form.
Therefore, at the present time, Creon is the drug of choice. It contains an optimal ratio of pancreatic enzymes.
It has a unique dosage form of mini-microspheres, which ensures uniform distribution of the drug throughout the entire volume of food and maximum digestive effect.
It is available in 3 dosages: 10, 25 and 40 thousand IU (Units according to the European Pharmacopoeia). The manufacturer of this medicine is the well-known company Solvay Pharma, Germany.
Taking Creon for unexpressed clinical manifestations of a lack of pancreatic enzymes is necessary in a dosage of 10,000 IU twice a day. For intense symptoms of digestive disorders, the daily dose can be increased to 40,000 IU. But only a specialist can accurately establish the regimen and course of treatment.
Doctor's recommendations
How to take Creon for any diseases accompanied by enzymatic deficiency should be indicated by the doctor when selecting the individual dosage. The initial dosage is usually 10,000–25,000 IU. The daily amount varies from 20,000 to 50,000 IU. The doctor also decides how long the course will last.
The condition of patients suffering from chronic pancreatitis is monitored twice a year. The complete regimen of anti-relapse therapy includes the use of:
- diet table No. 5p;
- a course of enzyme preparations lasting 4-6 weeks;
- antispasmodics (No-spa, Duspatalin) or prokinetics (Motilak, Domrid, Motilium) for a course of 2-3 weeks to relieve spasms;
- choleretic agents for a duration of 2-3 weeks if necessary.
In foreign practice, to eliminate pain, it is preferable to use pancreatin preparations that do not have enteric coatings, the effect of which begins to develop already in the stomach. To protect enzymes from the action of gastric juice, these drugs are combined with proton pump inhibitors (omeprazole and subsequent representatives). But there are no such pancreatin preparations on the domestic market, so Creon is considered the most effective remedy.
Why Creon
According to numerous studies and reviews from specialists, Creon, unlike many similar drugs, has a rapid clinical effect, which allows you to quickly reduce the severity of pain, expand the range of dietary nutrition, eliminate symptoms of flatulence, reduce the number of bowel movements, and also normalize stool consistency. The time to achieve the first effect, thanks to the specialized dosage form, is only 4-5 minutes.
Minimicrospheres have a shell that dissolves only in the intestine. They are specially enclosed in a gelatin capsule to make it easy to take. When exposed to the acidic gastric environment, the gelatin capsule disintegrates, and small enteric mini-microspheres are distributed throughout the food. Then, as part of the bolus of food, they move into the small intestine, where, under the influence of an alkaline environment, the active substances are released. They promote rapid breakdown and complete absorption of all nutrients.
Indications and contraindications of the drug
It is used as a replacement treatment for pancreatic enzyme deficiency, which is observed in the following diseases and conditions:
- cystic fibrosis;
- chronic form of pancreatitis;
- pancreatomy (removal of part);
- gastric resection (removal of part);
- gastrectomy (complete removal);
- malignant neoplasms of the pancreas;
- blockage of the pancreatic or common bile ducts;
- Shwachman-Diamond syndrome.
To answer the question whether it is possible to drink Creon during an exacerbation of pancreatitis, you need to look at the instructions. The contraindications section states that it, like other pancreatic enzyme preparations, is not used in the acute form of the disease, as well as during exacerbation of chronic pancreatitis. This is due to the fact that at this time the inflamed pancreas often produces increased amounts of enzymes.
As a result, the pancreas digests its own tissues and has a negative effect on other organs. Its use in the form of replacement therapy is possible only during the period when the symptoms of chronic pancreatitis subside. Another contraindication is an allergy to the components of the medicine, which is very individual.
Use during pregnancy and lactation
It is assumed that there is no toxic effect of pancreatic enzymes of porcine origin on the reproductive function of the body and the development of the human fetus. However, the drug should be prescribed during pregnancy only in special cases when the expected therapeutic effect for the mother significantly exceeds the possible threat to the fetus.
Taking Creon 25,000 during lactation is indicated, since it does not imply any harmful effects on the child through breast milk.
If enzyme therapy is necessary during pregnancy or breastfeeding, the dose of the drug should sufficiently maintain adequate nutritional status.
Negative phenomena and analogues
Side effects during treatment with this multienzyme drug predominated in the digestive tract. The most common symptoms were abdominal pain, slightly less commonly diarrhea, and nausea, vomiting, constipation and bloating. In addition to dyspeptic disorders, there were rare side effects in the form of rashes, urticaria and itching.
All pancreatin preparations can be divided according to dosage form and composition, which determine the bioavailability and effectiveness of the drug. Analogues in the pharmacological group are enteric tablets:
- Gastenorm forte;
- Mezim forte;
- PanziCam;
- Panzim Forte;
- Pakreazim;
- Pancreatin-LecT;
- Penzital;
- Enzistal;
- Unienzymes MPS;
- Pankreoflat, which in addition to pancreatin contains dimethicone for bloating and flatulence.
Another combined form of enzyme preparations is represented by enteric tablets Festal. It contains pancreatin, bile and hemicellulase. Manufacturer: Aventis Pharma (India).
Dosage forms similar to Creon have:
- Mikrasim and Panzinorm, which are produced in the form of capsules with pellets inside;
- Pangrol – capsules with mini-tablets;
- capsules with Ermital microtablets, which are the main competitor of Creon.
The frequently asked question: “Which is better: Ermital or Creon, Creon or Mezim?” can be easily answered by contacting a qualified doctor. According to reviews of leading domestic specialists and scientists, Creon is the No. 1 drug of choice for the treatment of pain and enzymatic deficiency in chronic pancreatitis.
Creon is a popular enzyme preparation containing pancreatin components in an optimal ratio (amylase, lipase and protease). The advantage over other similar products lies in the release form - microgranules up to 1.2 mm in size in a gelatin capsule. This makes it possible to ensure protection of the contents from hydrochloric acid, the beginning of dissolution in the alkaline environment of the small intestine, uniform mixing with food and a fairly rapid action. But you need to know how to take Creon in order to achieve the best possible results.
For other diseases
The dosage for adults is three to eight capsules with each meal. Independently setting the dose provokes complications of the disease.
Creon while breastfeeding
Pregnancy and lactation.
Pregnancy is not a contraindication to taking enzymes. Pregnant women can take this drug if its benefit to the mother significantly outweighs the possible harm to the child. To minimize the threat to the health of the unborn child, you need to take a minimum dose of enzymes.
Breast-feeding.
Enzymes do not have a negative effect on the child’s health and therefore Creon 10,000 thousand can be taken in the amount of one or two capsules per day, the dose depends on the disease.
An overdose of the drug has a side effect in the form of uric acid diathesis. In case of uric acid diathesis, you should stop taking the drug and carry out maintenance therapy.
Sometimes patients may experience side effects such as:
- Nausea.
- Vomit.
- Temperature.
- Diarrhea.
- Hives.
Side effects from Creon
In some cases, Creon 10000 can be replaced with one of its analogues:
Analogues differ not only in price, but also in composition. For example, the well-known drug Mezim Forte does not contain pancreatin. Doctors do not recommend changing Creon 10000 to Mezim or a similar analogue on your own, since pancreatin is effective in treating most gastrointestinal diseases.
The drug is prescribed not only for the treatment or maintenance therapy of the above diseases. Creon 10000 can be consumed by healthy people to improve food digestion. Then, the dose should be the minimum, as during pregnancy. In the latter case, it is not recommended to take this remedy for a long time, thus, you can block the production of your own enzymes.
Creon 10000 is one of the most popular representatives of modern enzyme products. It is used for enzyme replacement therapy for pancreatic enzyme deficiency. To ensure maximum effect, it is important to consider how to take Creon 10000 correctly. It must enter the intestines simultaneously with food. Only in this case will it be possible to reproduce the natural process of digestion, when enzymes are released in response to food entering the intestines.
Rules for taking Creon for adults
Adults should understand that the use of Creon is limited to a targeted replacement task. There are 2 options for need:
- pathology of the pancreas or the associated biliary system (chronic pancreatitis, removal of part of the organ, tumors, cholecystitis, consequences of cholecystectomy, hereditary diseases);
- secondary deficiency of enzyme production in diseases of the digestive system, confirmed by tests and symptoms (diarrhea with fatty feces, bloating, pain).
Any prescriptions for poisoning, gastritis, intestinal dysbiosis, cholecystitis will be made correctly only by a doctor based on examination and examination of the patient.
Creon is not suitable for one-time relief of heartburn, diarrhea or constipation. There are other medications for this. Attempts to take it for other purposes do not produce results and may result in an allergic reaction or other unexpected consequences.
The drug is available in a convenient dosage. It is calculated based on the lipase content in the capsule in international units (10,000 units, 25,000, 40,000). You should not buy Creon 40000 right away in order to save money, since cutting and opening capsules is not recommended for adult patients.
The dosage of Creon for 10,000 adult patients allows them to consume the required number of capsules to meet the daily requirement, but is more often used by pediatricians to treat children. For adults, it is possible to combine the drug in 25,000 and 10,000 units.
It is recommended to divide a single dose into approximately 3 parts: drink 2/3 before meals, 1/3 at the end of meals.
The medicine must be taken with at least a glass of water. The general drinking regime needs to be increased to 1.5-2 liters. For the treatment of small children who are unable to swallow the capsule, it is allowed to open and mix the contents with breast milk, nutritional formula, and wash down with slightly acidified juice.
It is strictly forbidden to take the drug during exacerbation of pancreatitis or acute inflammation. The additional supply of enzymes in such cases helps the destruction of gland tissue and self-digestion. When it is possible to start using Creon, doctors decide 1.5-2 weeks after the acute symptoms have subsided.
The drug combines well with other medications. But for full manifestation of the properties, it is recommended to use them with a break of 1-2 hours.
The effectiveness of the treatment process is judged by the improvement of the patient’s well-being, the cessation of diarrhea and flatulence, and weight restoration.
Use by children
It is important not only to know how to use Creon 10000 for adults, but also for children. For children, the medicine is prescribed for a lack of enzymes as a result of a violation of the physiological development of the digestive organs. In this case, symptoms such as:
- increased gas formation;
- stool disorders;
- belching;
- heaviness after eating food.
Such children are very sick, they eat little, and are underweight. The drug "Creon 10000" promotes better digestion of food due to the content of enzymes. This medicine is characterized by the fact that it can be given even to infants. It is considered the most acceptable remedy.
Treatment regimens depending on the form of release of the drug
In the treatment of various diseases, the daily dose of the drug is calculated, and then it is converted into the number of tablets. For example, if the doctor determined the need for 35,000 units, then you can divide it into 3 doses: 2 times 10,000 and 1 - 15,000. This will look like 2 times 1 capsule of Creon-10,000 and 1 time - one and a half capsules (one will have to be divided in half ). Or get by with two doses: drink Creon-25,000 (1 capsule) for breakfast, and 10,000 (1 capsule) for lunch.
Creon 40000 is only suitable for adults and severe cases. The drug is always taken orally. The dosage depends on the composition of the diet (percentage of allowed fats).
With any regimen, the prescribed dose is partially drunk before starting a meal, the rest during or immediately after. Microgranules should not enter an empty stomach.
Treatment methods for adult patients include starting with a small dosage, so Creon 10,000 or 25,000 is used. If there is no result, the doctor increases the dosage after a few days. How many units depends on the patient’s condition. It is often possible to achieve an effect if you take an average of 20,000–50,000 U of lipase per day.
But there are often cases when a much larger dose is needed: up to 75,000 units at each meal with three meals a day and an additional 5,000–10,000 if you want to eat in between.
The method of replacing enzyme deficiency involves a main course with a fairly high dosage of the drug and a maintenance course. For inflammatory diseases of the pancreas and biliary system, the duration of the main course of treatment with Creon ranges from two weeks to a month. During this period, it is usually possible to achieve stabilization of the secretory activity of the gland, so it is possible to remove strict restrictions on the diet and reduce the dosage.
In case of secondary gland insufficiency, a single dose of 25,000–50,000 units (depending on the amount of allowed fat) + half for snacks is prescribed for temporary use against the background of other medications and diet.
Treatment for cystic fibrosis begins in infancy, when the disease is diagnosed. Pediatricians have to make calculations based on the baby’s weight. Until children reach four years of age, it is customary to prescribe an average of 1000 units per kg of body weight per day for each feeding. At the age of 4 years, the dose can be increased by 500 U/kg over three times. It is not recommended to exceed a dosage of 10,000 U/kg per day.
Correction upward or downward is carried out after examining stool scatology. Children are registered at the dispensary and require increased attention and monitoring of their condition.
How to take Creon 10000?
Creon 10000 should be taken as specified in the general rules. Since this form of the drug was created mainly for children, we will focus on the features of treating a child with pancreatic enzymatic insufficiency.
In pediatric gastroenterology, there are 2 hereditary genetic diseases that, in addition to other organs and systems, affect the functions of the pancreas: cystic fibrosis and Shwachman-Diamond syndrome. The condition of children requires constant intake of enzymes. The dosage is calculated according to the weight and age of the small patient.
Capsules of 10,000 units of lipase allow you to adjust and select the optimal amount according to need.
The child is forced to constantly follow a strict diet and take the drug throughout his life. Transplant surgeons are trying to find a solution in transplanting a donor gland. Let's hope that the work will be crowned with success.
For babies, mothers are allowed to open the capsule and mix the contents with milk, soft food that elders will not chew. It is recommended to maintain a slightly acidic environment. Fruit purees, apple and orange juice are suitable. The prepared mixture cannot be stored; it should be drunk immediately after dilution.
In order to temporarily overcome secondary deficiency after an intestinal infection (the work of the gland is most severely affected by rotavirus infection, the intestinal form of influenza), food poisoning, Creon 10000 is prescribed to children along with probiotics and vitamins to restore digestion. The method of administration does not change; the dosage is prescribed by the doctor in each specific case individually for a period of up to a month.
Treatment with Creon 25000
Creon 25000 is suitable for older patients with cystic fibrosis. So, with a body weight of 60 kg, you need to take 1 capsule of 25,000 units at least three times a day. Up to 8 capsules may be required. Form 25000 is considered strong in terms of the components it contains. It is inconvenient in treating children.
A combination with Creon 10,000 and 40,000 is possible. Selection of the dose does not force you to divide the capsules. All principles of taking the drug are observed. Since we are talking about an extreme dosage, it is necessary to exclude negative effects (tendency to allergic reactions, constipation, the appearance of abdominal pain, indicating the formation of adhesions). The symptoms should be checked by a doctor. If an overdose is confirmed, the drug is discontinued.
Rules for taking: before meals or after?
Patients who constantly take Creon get used to drinking the medicine in accordance with the instructions during meals or immediately after, they know that even small snacks require additional dosage. The drug should not be taken on an empty stomach. The microgranules must be mixed with the food contents.
Conditions for dispensing from pharmacies
Capsules are taken orally, during each meal or immediately after meals (including light snacks), swallowed whole, with a sufficient amount of liquid.
If swallowing is impossible (small children, elderly patients), the capsules can be carefully opened and their contents mixed with soft, cool food that does not require chewing or liquid. The acidity (pH) of food or liquid should be below 5.5. Minimicrospheres can be mixed with applesauce, yogurt, or apple, orange, or pineapple juice with a pH less than 5.5. Do not expose the contents of the capsules to hot food or liquid! Any of the mixtures should be prepared immediately before use.
The dose of Creon 25,000 is selected individually, taking into account clinical indications, diet and severity of the disease.
Recommended dosage for cystic fibrosis for each meal:
- adults and children over 4 years of age: at the rate of 500 lipase units per 1 kg of weight;
- children under 4 years of age: initial dose – 1000 lipase units per 1 kg of weight.
When determining the dose, it is necessary to use the results of fecal tests for steatorrhea. The dose should ensure that the patient maintains adequate nutritional status. Usually it is no more than 10,000 lipase units per 1 kg of body weight per day or 4,000 lipase units per 1 g of fat consumed.
For other conditions accompanied by exocrine pancreatic insufficiency, the dose that should be taken with the main meal may be 25,000–80,000 IU of lipase, with a light snack - half the individual dose.
The use of Creon 25000 in children must strictly comply with the doctor's prescription.
Symptoms of pancreatin overdose are hyperuricemia and hyperuricosuria.
Treatment: stop taking capsules and carry out symptomatic therapy.
Available without a prescription.
Reviews about Creon 25000 are mostly positive. Patients report improvement and restoration of the digestive process after completing a course of therapy. The capsules are easy to take, and if there are problems with swallowing, their contents can be taken without the capsule shell, which is especially convenient when treating children. The drug is effective and safe. There are practically no descriptions of adverse reactions caused by its use.
The only indicated disadvantage is the high cost.
The price of Creon 25,000 for 20 capsules per package is approximately 568 rubles.
CREON 25000 20 pcs. enteric capsules
Creon 25000 caps. ksh/sol 300 mg n20
Creon 25000 25000 units enteric capsules 20 pcs.
Creon 25000 units 20 caps
Creon 25,000 caps 25,000 units No. 20
CREON 25000 50 pcs. enteric capsules Abbott Laboratories GmbH
Creon 25000 caps. ksh/sol. 25000 units No. 50
Creon 25000 units 50 caps
Creon 25,000 caps 25,000 units No. 50
Education: First Moscow State Medical University named after I.M. Sechenov, specialty “General Medicine”.
Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!
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The drug "Creon" is often prescribed to patients, as it can restore the normal functioning of the digestive organs. The main active substance of the drug is considered to be enzymes, which are produced in small quantities in the human gastrointestinal tract. Creon 25000 instructions for use state that it is necessary to take the medicinal product only as prescribed by a doctor, otherwise you can seriously harm your health, as well as aggravate the course of the disease. How to take the medicine correctly and what needs to be taken into account when conducting a course of treatment with Creon 25000?
The instructions for use state that it is necessary to take the medication if patients have the following pathologies:
- cystic fibrosis;
- diseases of the pancreas that occur in a chronic form;
- complete removal of the gland;
- narrowing of the lumen of the ducts as a result of compression by tumors;
- cancer of the gland;
- inhibition of enzyme-forming function (this condition is often observed in older people).
Often the medicine is prescribed to patients to relieve symptoms of gastrointestinal dysfunction resulting from the following diseases or pathological conditions:
- cirrhosis of the liver;
- removal of part or all of the stomach for health reasons;
- inflammation of the liver, which occurs along with cholestasis;
- removal of the gallbladder;
- narrowing of the lumen in the gallbladder due to stones, parasites, tumors;
- pathological changes occurring in the intestinal cavity after radiation therapy;
- dysbiosis.
However, like any other medicinal product, Creon 25000 has contraindications.
These include:
- intolerance by the patient to the components included in the medicinal product;
- inflammation of the pancreas, which occurs in an acute form (the main substance of Creon can worsen the state of health and also aggravate the course of inflammation);
- exacerbation of chronic inflammation of the pancreas, which occurs with pronounced symptoms.
In such cases, the doctor will prescribe a safer drug to the patient that will not cause side effects or health problems, and will also help to quickly restore the functioning of the digestive organs.
When using the drug Creon 10000 in doses exceeding the recommended ones, an overdose may occur. This condition is characterized by hyperuricemia and hyperuricosuria, which are manifested by an increase in uric acid levels, determined during a biochemical blood test. Symptoms of these conditions are:
- pain in joints and muscles;
- increased sweating;
- headache;
- dizziness;
- abdominal pain;
- nervous tics.
To eliminate hyperuricemia and hyperuricosuria, symptomatic treatment is carried out and a suitable diet is prescribed.
How much and in what cases should I take it?
"Creon" is available in varying degrees of "strength", which is expressed in units of enzymatic activity. The higher the number, the more active the drug. The following dosages of the drug are currently available:
- 10,000 units (0.15 g capsule, or 150 mg, 20 capsules per pack);
- 25,000 units (0.3 g capsule, or 300 mg, 20 capsules per pack);
- 40,000 units (50 capsules in a bottle).
"Creon" and its analogues are "democratic" drugs. Since the drug is indicated for replacement therapy, taking the drug should not be a one-time use: this will lead to nothing.
How long can you take Creon 10,000 and more concentrated analogues? At least for life. After all, its role is simple: the drug does not interfere with the functioning of the body, but simply adds something that should be constantly produced in it, but is not produced due to a certain defect.
As for the use of the drug in pediatric practice, this is possible - there are no special contraindications. “Creon” 10,000 for children is the most popular dosage, but adults, especially tall ones, need to use more concentrated versions of the drug.
How to take Creon for adults and children? The most important thing is that the drug is taken with food, and the food is washed down with a sufficient amount of liquid. After all, all enzymes work in the liquid phase. That is why, if you are in doubt about how to give Creon to a child, if the drug was missed during meals, then it is better not to take it (on an empty stomach). After all, if enzymes enter the intestines when there is no food there, they will begin to harm the intestinal wall.
Contraindications
There are very few contraindications to taking enzyme preparations: acute inflammation and exacerbation of chronic pancreatitis.
The use of Creon tablets is prohibited for two reasons: firstly, in case of acute pancreatitis and exacerbation, “hunger, cold and rest” are prescribed. Since food does not enter the intestines, then the enzymes that help break it down have nothing to do there either.
And secondly, in acute pancreatitis, enzymes are not friends, but worst enemies, since they cause autolysis, or self-digestion of gland tissue. And it’s really not worth helping the disease destroy a vital organ.
The danger of uncontrolled treatment with Creon: a doctor’s opinion
A good drug, when following the advice of incompetent people, is not only ineffective (some manage to treat heartburn, take Creon out of heavy drinking), but also exhibits negative properties. Allergic reactions are known in the form of urticaria, nausea, facial swelling, increased pain in the epigastrium, and stool upset.
When examining a patient, it is possible to detect a high level of uric acid in the blood plasma. This causes joint and muscle pain, dizziness, sweating, and twitching of the facial muscles. The drug is discontinued, although not all doctors are sure that a minor disease led to the negative effects.
Taking Creon should be done strictly after consultation with a doctor. There are many diseases for which other enzymes in combination with bile are more useful. You should not fall for advertising tricks of unknown persons and untested methods of therapy. Creon does not interfere with pathology, but only helps support the absent or weakened pancreas.
Composition and release form
The contents of each capsule are a set of specific pancreatic enzymes. Next to the name of each type of drug, the number of thousands means how many units of lipase are contained in one capsule. There are three types of Creon capsules: 10, 25 and 40 thousand each.
The first type of capsule contains 0.150 g of pancreatic extract in the form of pancreatin, which contains 10 thousand units of lipase enzyme, 0.6 thousand units of protease and 8 thousand amylase.
The second composition already contains 0.3 g of pancreatin, and the number of units of lipase is 25 thousand, protease - 1 thousand, amylase - 18 thousand.
The largest amount of pancreatin (0.4 g) is contained in the third type, the content of lipase is 40 thousand, 1.6 thousand protease and 25 thousand amylase.
Polyethylene glycol 400 is used as auxiliary components for the formation of cores in granules, and the shell is made from hydroxypropyl methylcellulose phthalate, ethyl (cetyl alcohol), selenium-containing dimethicone, citric acid ester and ethylene.
The base of the capsule shell is formed by gelatin, with the addition of various dyes: iron oxide, titanium dioxide, and sodium dodecyl sulfate.
Medication "Creon": patient reviews
This product belongs to a new generation of drugs, since it is produced in the form of enteric capsules with the contents in the form of complex granules. Unlike the drug Creon, its analogues are produced in tablet form, which reduces the function of enzymes, which, when the tablet shell dissolves, enter the stomach and are exposed to hydrochloric acid. As a result, a small part of them reaches the intestine, where they must perform their function of breaking down proteins, fats and carbohydrates.
Thanks to the capsulated form of release of the drug "Creon", reviews of its best therapeutic effect can be heard from many patients who have switched to treatment with this drug. This medication has established itself as a fast-acting, effective drug, which is considered the best in its pharmacotherapeutic group.
Side effects
- from the gastrointestinal tract: very often – pain in the abdominal area; often – bloating, nausea, vomiting, diarrhea or constipation; frequency unknown - fibrosing colonopathy (formation of strictures of the ileum, cecum and/or colon while taking high doses of pancreatin for cystic fibrosis).
- dermatological reactions: infrequently - rash; frequency unknown - itching, urticaria;
- from the immune system: frequency unknown - anaphylactic reactions with hypersensitivity.
The interaction of Creon 25000 with substances/drugs during the simultaneous use of other drugs has not been established.
What does Creon and its analogues help with? Unlike many drugs that affect individual links in pathogenesis, Creon simply gives the body what it lacks, namely enzymes. Of course, this drug does not contain human enzymes, since their production using genetic molecular engineering will be too expensive. Enzymes from cattle are quite sufficient. The following enzymes are isolated from pancreatic tissues of slaughtered animals:
- pancreatin (a mixture of enzymes representing a gray-yellow powder);
- amylase (for breaking down carbohydrates)
- lipase (for fats)
- proteases (for proteins).
The drug is produced in an enteric coating. After all, normally these enzymes work in the duodenum, where the environment is much more alkaline than in the stomach.
The mechanism of action is very simple: if you take a few capsules with food, the enzymes, released in the intestines, will begin to “help” the pancreas cope with the digestion of food. That is why all enzyme products are taken with meals. What are the indications for taking Creon?
Analogs
Enzyme preparations produced in tablet form have long existed on the pharmaceutical market. The analogues of the drug "Creon" have the same composition of active enzymes contained in pancreatin, and they all help digest food. The difference between a capsule product and tablets is the faster release of the active substance in the intestines, which allows it to begin to act earlier. That is why it is considered more effective, and therefore its cost is higher than that of similar drugs.
If you don’t have enough money to buy the expensive drug “Creon”, analogues in the form of medicines “Panzinorm”, “Pancreatin”, “Micrazim”, “Pankrelipase” are sold in pharmacies at a lower price.
How does the drug work?
The contents of the capsules consist of gastro-resistant granules in the form of minimicrospheres. The mechanism of action of the drug "Creon" is associated with the gradual splitting of first the shell of larger granules, and then smaller ones. Each large mini-microsphere is covered with a stomach-soluble coating; after its destruction, smaller microspheres are released from each such granule, but with an enteric coating. Dissolving the coating of the small granules allows the active components to be released, which mix with food in the small intestine. This promotes the lipid, protein or carbohydrate breakdown of fats, proteins and carbohydrates into amino acids, fatty acids, trihydric alcohol and monosaccharides, which facilitates the process of absorption through the intestinal wall into the blood.
Diseases that the drug treats
For replacement therapy in conditions of insufficient exocrine function of pancreatic cells, the drug “Creon” is used. The use of this remedy is possible for cystic fibrosis, chronic inflammatory processes in the pancreas or when it is removed, in case of obstruction of patency by tumors of the pancreas or bile duct, malignant neoplasms, Shwachman-Diamond syndrome, and age-related disorders in the production of enzymes.
It is used to eliminate symptoms of digestive disorders associated with the removal of the gallbladder, some parts of the intestine according to Billroth (variants I and II), excision of the entire stomach with the subsequent formation of an esophageal-intestinal anastomosis, with the syndrome of slow emptying of the stomach cavity and slow movement of food through the lumen of the duodenum. Used in patients with obstruction of the bile ducts, cholestatic hepatitis, cirrhosis of the liver, pathological changes in the terminal section and excessive growth of bacteria in the small intestine.
Dosages and rules of administration
The drug is intended for oral use. A single dose is divided in half or into three parts, half or a third of the dose is drunk before meals, and the rest is taken with food. The dosage depends on the degree of the disease state and the components of the diet. The amount of lipase in one dosage should not exceed 10 thousand units when taking the drug "Creon". The course of treatment with this drug is determined by the doctor based on the dynamics and condition of the patient.
In order for the drug “Creon” to work correctly, it is recommended not to break the capsule shell, but to drink the whole one, using water for better swallowing.
If the patient, due to special reasons, cannot swallow the whole capsule, then the shell is divided into two parts and the granules are poured into liquid food or a liquid with an acidic environment (less than 5), and then the mixture is swallowed. If the granules are chewed, crushed or mixed with alkaline food, then the shell covering the minimicrospheres may collapse, which will lead to the loss of activity of their contents under the influence of gastric juice.
The dosage of lipase for insufficient pancreatic function is determined by the degree of disruption of its functioning and the amount of fat in the patient’s diet. Its quantity, when used three times a day during breakfast, lunch and dinner, ranges from 20-75 thousand units.
At the initial stages of treatment, the amount of lipase in one dose should average from 10 to 25 thousand units, and then, depending on the condition, it is increased.
special instructions
Impact on the ability to drive vehicles and operate machinery
The medication does not disrupt the speed of natural psychomotor reactions.
Pregnancy and lactation
The use of Creon during pregnancy is possible only if there are special indications (the risk to the fetus should be minimal). It is recommended not to take the drug during lactation.
Use in childhood
It is not recommended to use the drug to treat children under four years of age.
In case of liver dysfunction
The manufacturer does not indicate the nuances of using the drug for liver dysfunction.
If kidney function is impaired
There are no special indications for the use of the drug in kidney pathologies.
Conditions for dispensing from pharmacies
Over-the-counter release from pharmacies.
Treatment of children with Creon
Almost all newborn babies have problems with the digestive system due to its imperfection. This is manifested by difficulty in digesting food, colic, rare stools and subsequent dysbacteriosis. The cause is insufficient production of digestive enzymes by pancreatic cells. To improve digestion, the doctor prescribes treatment with Creon for infants. Reviews from parents whose children were prescribed this medication indicate its effectiveness and safety of use. After taking the drug, food is better broken down in the intestines, the absorption of nutrients improves, and stools are normalized.
The drug “Creon” is very effective for children. The instructions describe the use of this remedy for chronic inflammation of the pancreas, when removing a diseased part of it, for digestive disorders, after irradiation, cystic fibrosis, bloating, frequent diarrhea, obstruction of the ducts in the pancreas, after gastric surgery.
Enzyme preparation for intestinal disorders
Creon is indicated for intestinal disorders caused by hypofunction of the pancreas and a lack of its enzymes. Diarrhea or constipation with colic and flatulence appear due to the presence of undigested food residues in the intestines. The condition is quickly complicated by changes in the balance of the flora of intestinal microorganisms. Opportunistic microbacteria become harmful and further contribute to inflammation of the mucous membrane.
Creon for diarrhea
Diarrhea that is not caused by poisoning often bothers children. The digestive system of a child under 4-5 years of age is imperfect and is very dependent on breast milk, the quality and timeliness of complementary foods, and the composition of formulas. Pediatricians are confident that the difficulties are temporary and will disappear as they grow older. Treatment for this type of diarrhea always includes a small dosage of Creon.
Support of the pancreas with enzymes is carried out by taking from 1000 to 10,000 units of the drug per day. For the child, the capsule is opened and the required dosage is given to drink in milk or as part of liquid food. It is recommended to give half before feeding, the rest after. An important result is the prevention of dysbiosis.
Creon for diarrhea should be taken with plenty of fluids. This is also necessary to relieve dehydration, which disrupts the functioning of the cardiovascular system in children. In such conditions, Creon has a negative effect in the form of constipation.
Use for constipation
In adults, constipation can be spastic or atonic and is associated primarily with impaired peristalsis. Therefore, Creon does not act. When treating constipation in children, it is assumed that it is possible to restore the enzyme composition of the intestines to normalize digestion.
A sufficient amount of digestive enzymes relieves the child of bloating and fecal retention. Creon-10000 is used. Children under 1.5 years of age are allowed a maximum of 5 capsules per day, older ones - up to 15.
Creon for periodic bloating and abdominal pain
Rare abdominal pain is expressed in rapid colic or longer distension. When you overeat, a feeling of heaviness in the stomach lasts for a long time. This is due to stretching of the organ and stagnation of heavy food. In such cases, you do not need Creon, but drugs containing the enzyme of gastric juice - pepsin and hydrochloric acid. They will help move the bolus of food into the intestines and process it to the desired consistency.
When painful sensations resemble girdling and descend to the navel area, then one should suspect involvement in the process and overload of the pancreas, lack of bile. Taking Creon together with choleretic drugs is indicated. Festal and Digestal, which contain bile, will have the best effect. Bloating goes away when digestion normalizes.
Children's dosages
Doctors often prescribe the drug "Creon" to children. The dosage of lipase per day for newborns should not exceed 10-15 thousand units. To give this drug to your baby, you need to remove the granules from the gelatin capsule and add them to breast milk or formula at room temperature.
For children under 4 years of age with signs of cystic fibrosis, the dosage of lipase at the beginning of treatment is equal to 1 thousand units per kilogram of weight during each meal, for children over 4 years of age it is 0.5 thousand units per kilogram of weight.
Taking the drug, as for adults, is divided into two stages, part of the dosage is given before meals, and the rest of the capsule contents are taken with food.
Instructions for use of Creon
Creon is used during meals, swallowing the capsules whole. It is recommended to take half or a third of a single dose immediately before meals, and the rest during meals.
The dose of Creon according to the instructions is determined individually, depending on the course of the disease and the diet used, using Creon in different dosages - 10,000, 25,000 or 40,000.
For cystic fibrosis, the initial dose of Creon for children under 4 years of age is 1000 IU of lipase per 1 kg, for children over 4 years of age - 500 IU of lipase per 1 kg. Creon is used during every meal, both main and additional. For children, Creon 10000 is usually used. If it is difficult to swallow the capsules, they can be opened and the mini-microspheres contained in them can be added to liquid food with an acidic pH
In case of insufficiency of pancreatic function for various nosologies, the dose is determined depending on the results of control of steatorrhea and the severity of symptoms of the disease to maintain 10,000 IU of lipase per 1 kg per day.
The dose of Creon can vary from 20,000 to 75,000 IU of lipase during the main meal, and during a light meal - from 5,000 to 25,000 IU of lipase.
Also, to prevent increased constipation, it is necessary to ensure constant fluid intake in sufficient volume.
According to reviews, Creon in overdose can cause hyperuricemia and hyperuricuria. In this case, Creon should be discontinued and symptomatic therapy performed.
The use of Creon during pregnancy and lactation has not been studied, so the drug can only be used as directed by a doctor.
